<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q56559</accession>
    <accession>Q7BSC4</accession>
    <accession>Q7BSC8</accession>
    <accession>Q7BSD3</accession>
    <accession>Q9PQ57</accession>
    <name>UREE_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureE</name>
        <name type="ordered locus">UU431</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="647" last="655">
            <title>Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli.</title>
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8550495"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Int. J. Syst. Evol. Microbiol." volume="54" first="1815" last="1821">
            <title>Postgenomic taxonomy of human ureaplasmas - a case study based on multiple gene sequences.</title>
            <authorList>
                <person name="Kong F."/>
                <person name="Gilbert G.L."/>
            </authorList>
            <dbReference type="PubMed" id="15388749"/>
            <dbReference type="DOI" id="10.1099/ijs.0.63073-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
            <strain>ATCC 27818 / Pi / Serovar 6</strain>
            <strain>ATCC 33697 / U26 / Serovar 14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreE family.</text>
    </comment>
    <dbReference type="EMBL" id="L40489">
        <property type="protein sequence ID" value="AAA89190.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085730">
        <property type="protein sequence ID" value="AAG10353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085731">
        <property type="protein sequence ID" value="AAG10358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085733">
        <property type="protein sequence ID" value="AAG10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F82890">
        <property type="entry name" value="F82890"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688775.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56559"/>
    <dbReference type="SMR" id="Q56559"/>
    <dbReference type="STRING" id="273119.UU431"/>
    <dbReference type="EnsemblBacteria" id="AAF30843">
        <property type="protein sequence ID" value="AAF30843"/>
        <property type="gene ID" value="UU431"/>
    </dbReference>
    <dbReference type="GeneID" id="29672354"/>
    <dbReference type="KEGG" id="uur:UU431"/>
    <dbReference type="eggNOG" id="COG2371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093757_3_1_14"/>
    <dbReference type="OMA" id="YVDLEWF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00571">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036402">
        <property type="entry name" value="Ureas_acces_UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-0996">Nickel insertion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000067639" description="Urease accessory protein UreE">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA89190." evidence="2" ref="1">
        <original>DNI</original>
        <variation>APL</variation>
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA89190." evidence="2" ref="1">
        <original>MAKIA</original>
        <variation>WQNC</variation>
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="149" mass="17374" checksum="05328FEA0A924AA8" modified="2000-12-01" version="2">MTVFKEILDNIANIKNVESYQIENIHLTSDDVLKRVIIISSDQNVEYGIRLEEDKKLMDGDILYKDDYKLVVIRLELSDVLIITAHTIGEMAKIAHNLGNRHMPAQFTETQMIVPYDYLVEEYLQDNKALYERKKIKLKEAFKHCSDAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ4</accession>
    <name>DEOC_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="1">DERA</shortName>
            <ecNumber evidence="1">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="1">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoC</name>
        <name type="ordered locus">UU585</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688583.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPQ4"/>
    <dbReference type="SMR" id="Q9PPQ4"/>
    <dbReference type="STRING" id="273119.UU585"/>
    <dbReference type="EnsemblBacteria" id="AAF30999">
        <property type="protein sequence ID" value="AAF30999"/>
        <property type="gene ID" value="UU585"/>
    </dbReference>
    <dbReference type="GeneID" id="29672297"/>
    <dbReference type="KEGG" id="uur:UU585"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_14"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000057283" description="Deoxyribose-phosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="215" mass="24109" checksum="BE5C0AAD558C1F55" modified="2000-10-01" version="1">MNKYNIYVDHTLLKADASLEEIHKLCEEAEENEFYSVCINPCFVKVAKHYLLETSVKICTVIGFPLGANTIETKVFETKNAIDLGADEIDMVININQLINGNREYCLNEINQIKEVCGDKILKVIVETAFLNREQKEFAAKIILESNADFIKTSTGFAKEGAKLEDIILWKRILGDVKQIKASGGIKNFEDFKSFIEAGATRIGTSSAIKILNNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR2</accession>
    <name>RL13_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">UU577</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688786.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPR2"/>
    <dbReference type="SMR" id="Q9PPR2"/>
    <dbReference type="STRING" id="273119.UU577"/>
    <dbReference type="EnsemblBacteria" id="AAF30991">
        <property type="protein sequence ID" value="AAF30991"/>
        <property type="gene ID" value="UU577"/>
    </dbReference>
    <dbReference type="GeneID" id="29672159"/>
    <dbReference type="KEGG" id="uur:UU577"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_14"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000055487" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="148" mass="17021" checksum="B6349A119A3D66D3" modified="2000-10-01" version="1">MQKSSMLKKEVAIARRQWYLVDATDLVLGRLSVKVADILRGKNKVDYTPNVDAGDYVVVINSDKVVLTGQKALRENWYNHSHYIGGLRTRSGEEMISKYSDELIRRSVKGMLPKNKLAKQILNKLFIYKNDKHPHEAQQPTILELKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR7</accession>
    <name>Q9PPR7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891819.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU572"/>
    <dbReference type="EnsemblBacteria" id="AAF30986">
        <property type="protein sequence ID" value="AAF30986"/>
        <property type="gene ID" value="UU572"/>
    </dbReference>
    <dbReference type="GeneID" id="29672768"/>
    <dbReference type="KEGG" id="uur:UU572"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.595"/>
    <dbReference type="eggNOG" id="ENOG50344AC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_471667_0_0_14"/>
    <dbReference type="OMA" id="INSEQYP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="578" mass="67402" checksum="9E9758B1F0AA8724" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS5</accession>
    <name>Q9PPS5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU564.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU564.1"/>
    <dbReference type="EnsemblBacteria" id="AAF30978">
        <property type="protein sequence ID" value="AAF30978"/>
        <property type="gene ID" value="UU564.1"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU564.1"/>
    <dbReference type="HOGENOM" id="CLU_2496967_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="86" mass="10079" checksum="F18EF71DA82F3350" modified="2000-10-01" version="1">MLWDYFLFSYILALKSYVKEPTLPLIYFDLLKIHFVNNASTLINFNCINIHLINNRNANNNKTRAKNTFAIKNANGMIKKFILIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS8</accession>
    <name>Q9PPS8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oppB</name>
        <name evidence="7" type="ordered locus">UU562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688659.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU562"/>
    <dbReference type="EnsemblBacteria" id="AAF30975">
        <property type="protein sequence ID" value="AAF30975"/>
        <property type="gene ID" value="UU562"/>
    </dbReference>
    <dbReference type="GeneID" id="29672636"/>
    <dbReference type="KEGG" id="uur:UU562"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.584"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_14"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="165"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="377" mass="41924" checksum="391626240B625A6F" modified="2000-10-01" version="1">MNQKNSFEANSSQNNYGELPILNQKKRVNYSFSNNFIIFGGGRSLKTAADRDRVVDPLIDFFTFDSKFMTFIIKSLKLIAEFFLLAWIVITITFFLINSVPGESALTIGITSPEAKKAILAQYGLDRPIGVRYVNYLANIFRGEFGVSTSIRPGVEINSFIWSRYLVSFAVGIFSVLLTLVIGIPLGIFVGRKPGGILDSVSTVIISVISAVPSLVFGLILLLIGKEVGLPFTFDINNFVTYILPGLALSLGSIIVYVQYIKVEMNRELNSMHAKFAYLKGATVNRFVWLHALKPSLFPIATFFPFVILGSFVGALFIEQIFQIPGSGSLFFEAIISKDYNVILLLVIIYSLITIIGYTIRDALYQIIDPRIRRGGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-24" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT7</accession>
    <name>SSB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="1">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ssb</name>
        <name type="ordered locus">UU553</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688666.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPT7"/>
    <dbReference type="SMR" id="Q9PPT7"/>
    <dbReference type="STRING" id="273119.UU553"/>
    <dbReference type="EnsemblBacteria" id="AAF30966">
        <property type="protein sequence ID" value="AAF30966"/>
        <property type="gene ID" value="UU553"/>
    </dbReference>
    <dbReference type="GeneID" id="29672533"/>
    <dbReference type="KEGG" id="uur:UU553"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_6_2_14"/>
    <dbReference type="OMA" id="MNQINIV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000096135" description="Single-stranded DNA-binding protein">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SSB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="166" mass="18500" checksum="56022477F2033788" modified="2000-10-01" version="1">MNKVILIGNLVRDPEARQIPSGRLVTNFTIAVNDNTPNANANFIRCVAWNNQANFLTTYLKKGDAIAIEGRIVSRSYVDNNGKTNYVTEVYADQVQSLSRRNQSPSDNNKVNVDTMMESYTGINTDAAFSSNKPQTTLSSTTSNLNKNNDEEDEITSWINLDDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU5</accession>
    <name>Q9PPU5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gatA</name>
        <name evidence="2" type="ordered locus">UU545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688421.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU545"/>
    <dbReference type="EnsemblBacteria" id="AAF30958">
        <property type="protein sequence ID" value="AAF30958"/>
        <property type="gene ID" value="UU545"/>
    </dbReference>
    <dbReference type="GeneID" id="29672468"/>
    <dbReference type="KEGG" id="uur:UU545"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.566"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_14"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="477" mass="53250" checksum="8119ED9EF143A2A6" modified="2000-10-01" version="1">MKNKTILALHNQIKKREVKIYDLIKKSIDHDLKIKNLNATLANNYEQALKQAAFLDEKISSDNLEIDYLFGIPYSLKDNISTKNIITTGGSLFLKNYNPPYDATVKTLLDQKQAILLNKSNLDEFGLGGTGTDSAFGPVINPLNPKHVSGGSSSGSAVLVQQGVVPFAIATDTGDSVRRPASIMGIVGFKPSYGLISRYGVYPFAPSLDHVGIFTNNIFDTQIVFNALAKRDFKDFTSLSFKTQSLSMLKTKNKYKIGVLKPSFDLLASKYQQELTNLIVKLNDEHEIINVDYDINLLKAISPVYKLIAFSEAYSSYSNFTNITFGKHDIDYDNYEDLIIKTRTLYLGTQLKQRFMIGAYVTQESQFETLLVAAKKMRTLIVDQAKNLFKNCDLILNLAVHDISETIDDVNNQKPTTNLVEDVMQIANFGGFPSIVIPFLTTKLGNLGLNLWADYLNDNKLLNGAYLINNLLGNEEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV7</accession>
    <name>RL33_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmG</name>
        <name type="synonym">rpl33</name>
        <name type="ordered locus">UU533</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688661.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPV7"/>
    <dbReference type="SMR" id="Q9PPV7"/>
    <dbReference type="STRING" id="273119.UU533"/>
    <dbReference type="EnsemblBacteria" id="AAF30946">
        <property type="protein sequence ID" value="AAF30946"/>
        <property type="gene ID" value="UU533"/>
    </dbReference>
    <dbReference type="GeneID" id="29672398"/>
    <dbReference type="KEGG" id="uur:UU533"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_14"/>
    <dbReference type="OMA" id="RYTTMKN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000170260" description="50S ribosomal protein L33">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="53" mass="6147" checksum="F7E1CE3B3FB50C1D" modified="2000-10-01" version="1">MAIKRGVRLQCNESKSINYITTKNAKNNPDRLSLNKFCPKCRKVTTHVEIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV9</accession>
    <name>Q9PPV9_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cdd</name>
        <name evidence="13" type="ordered locus">UU531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688691.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU531"/>
    <dbReference type="EnsemblBacteria" id="AAF30944">
        <property type="protein sequence ID" value="AAF30944"/>
        <property type="gene ID" value="UU531"/>
    </dbReference>
    <dbReference type="GeneID" id="29672389"/>
    <dbReference type="KEGG" id="uur:UU531"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.551"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_0_1_14"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAF30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="131" mass="14596" checksum="D1437D4B10BF66A6" modified="2000-10-01" version="1">MKYNDIYMGLLELLKKSYSPYSNYPVAAYVDTDLGFISGVNVENGSFGLTSCAERNAIFNAIANGAKTFKTVYIITKNNGDIASPCGACRQVIFEFFKKDAKIVVFNNDGTYKEYNVEQLLPFGWDPNISL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW7</accession>
    <name>EFG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor G</fullName>
            <shortName>EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fusA</name>
        <name type="synonym">fus</name>
        <name type="ordered locus">UU523</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688607.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPW7"/>
    <dbReference type="SMR" id="Q9PPW7"/>
    <dbReference type="STRING" id="273119.UU523"/>
    <dbReference type="EnsemblBacteria" id="AAF30936">
        <property type="protein sequence ID" value="AAF30936"/>
        <property type="gene ID" value="UU523"/>
    </dbReference>
    <dbReference type="GeneID" id="29672349"/>
    <dbReference type="KEGG" id="uur:UU523"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_14"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091258" description="Elongation factor G">
        <location>
            <begin position="1"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="6"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="688" mass="76430" checksum="2F43850BAF6DE42D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX8</accession>
    <name>Q9PPX8_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cdsA</name>
        <name evidence="9" type="ordered locus">UU511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688680.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU511"/>
    <dbReference type="EnsemblBacteria" id="AAF30924">
        <property type="protein sequence ID" value="AAF30924"/>
        <property type="gene ID" value="UU511"/>
    </dbReference>
    <dbReference type="GeneID" id="29672209"/>
    <dbReference type="KEGG" id="uur:UU511"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.531"/>
    <dbReference type="eggNOG" id="COG0575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_2_0_14"/>
    <dbReference type="OMA" id="VFTAAPW"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="378" mass="43612" checksum="29C7009607AAF5AE" modified="2000-10-01" version="1">MISVNKINEKTKNTFFKRFYSSIFIFLYLLIYFVLALLADRNYNWTPLINNLYIQQGIAIVLLIWLLPLICIGSYEMNKVIFDNNKITLIILTIVFNICIYTTTISYFIYQYEFLNIKYLLTINYHYVIKLFGACLGCSYFVTLVILFFFLAFLKKINFKNCLYTILIFSFLSGFFIGLLYFTFIRSWITSLLLMMIVFLSDTFAYVGGVLFGKTKLAPKISPNKTVEGLIFGLVIATIVIMLIIFGLSYVPIKPKNGIVLKSQNVLYNIFGLDFSSSNEKNLTLHKQALWWICTIVAFLFLSLISTSGDLVFSAIKRNYHTKDYSNLIPGHGGLLDRIDSHSFVISIMFIFTLLITGSLQDENLFPNIQKFFIQLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY1</accession>
    <name>Q9PPY1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688789.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU509"/>
    <dbReference type="EnsemblBacteria" id="AAF30921">
        <property type="protein sequence ID" value="AAF30921"/>
        <property type="gene ID" value="UU509"/>
    </dbReference>
    <dbReference type="GeneID" id="29672309"/>
    <dbReference type="KEGG" id="uur:UU509"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.528"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_2_14"/>
    <dbReference type="OMA" id="PWLLMKI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_J_C" evidence="1">
        <location>
            <begin position="452"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="556" mass="62758" checksum="42FF5A4F83F21586" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY3</accession>
    <name>Q9PPY3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosol aminopeptidase (Leucine aminopeptidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ampL</name>
        <name evidence="7" type="ordered locus">UU507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688463.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU507"/>
    <dbReference type="EnsemblBacteria" id="AAF30919">
        <property type="protein sequence ID" value="AAF30919"/>
        <property type="gene ID" value="UU507"/>
    </dbReference>
    <dbReference type="GeneID" id="29672448"/>
    <dbReference type="KEGG" id="uur:UU507"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.526"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_6_3_14"/>
    <dbReference type="OMA" id="HFDIYGW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="307"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="455" mass="50629" checksum="4617B46231FE69E4" modified="2000-10-01" version="1">MTLNEKKEFVYELKAVEKNHNLKGFEENTTEHVVFGGLYQKQQYLILTPDFDSNELSRSLISFLEKSPKSVSVDLNSFLSLVPESRHASLLNVVISALEYVEVTPFSLKSKIETKNIHNLVVDQKYHDLINKLHVIAQSQTITRTLQDTPANLMTPGDFEERIKELFKDLPEVKVSVLYRKDLEAKGMNAHVGVGKAAVSDKAQPRLVVVEYNNNPETNEKYAFVGKGVCFDSGGYNVKTGSHMRWMKFDMSGSAIVSMTVRALALNKEKVNVVAVCPLVLNLLAPEGQKPDDIVKSYNGKTIELDNTDAEGRLILADALTYAVRDLKASKLFDVATLTGAMIYALGDTYSGVWATNNDIWNEVVVAADYAGELVWRLPFHNDFLKMLNSNVADIANSVSDPRGGSSRAACFLKEFTEGVPYAHFDIAITADVGHKGTGVMLRTFYRIAQNQKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY6</accession>
    <name>Q9PPY6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU504"/>
    <dbReference type="EnsemblBacteria" id="AAF30916">
        <property type="protein sequence ID" value="AAF30916"/>
        <property type="gene ID" value="UU504"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU504"/>
    <dbReference type="HOGENOM" id="CLU_729460_0_0_14"/>
    <dbReference type="OMA" id="ENTMINT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="387" mass="46721" checksum="8A1FE952C2959C5B" modified="2000-10-01" version="1">MKKKVIKMINNSPNINYYLQDKKYIPKYAYYVNKKQKPIELFARYKGRPALFIRENTMINTSLNSNVLNLDFEFEVAGDFKLPINYFFMDIKSDIGEFRNLEVYETKHSLYEIGGVIYDLYTYKTNLKINLNQAGFVNKNTLSKKINFAFFLRINDDKRIHEQINYTCEKSLFFEAVQKEFQDLNFDYFYKNTFLLNKHEKVNPTNFWETIPLFWIQDKELDNEIKIKNNKRYIFNTKFSLNDDNSWNNRPTKETFELIKYSLEYVNLAKENKKIEWIEDYQNINITYDYYQRPIDFLLKMKTKFLYDFKNDQLSINNNYGFNGIWLPNKQIAKLKITVINNYLTPQKFVINQLINIENDFNSINKQKISVQKAIIENYENFKSLEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPZ9</accession>
    <name>ERA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">era</name>
        <name type="ordered locus">UU491</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAF30903" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30903.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B82884">
        <property type="entry name" value="B82884"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688444.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPZ9"/>
    <dbReference type="SMR" id="Q9PPZ9"/>
    <dbReference type="STRING" id="273119.UU491"/>
    <dbReference type="EnsemblBacteria" id="AAF30903">
        <property type="protein sequence ID" value="AAF30903"/>
        <property type="gene ID" value="UU491"/>
    </dbReference>
    <dbReference type="GeneID" id="29672538"/>
    <dbReference type="KEGG" id="uur:UU491"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_14"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000180069" description="GTPase Era">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Era-type G" evidence="2">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="2">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="2">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="2">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="300" mass="34552" checksum="F85DE5A834848259" modified="2001-05-04" version="2">MIKKYGIVAIVGKPNVGKSTLINAIMKKKVSIISNKPQTTRNAVKEIYEDDESAIIFTDTPGFHEPSNKLDLFLNHEIEISYKEANVILFVTTMDKELDANDFEIINLIKEANKENIILVISKAEMAKNQDQIDERIHFLKKHIAFKDVVQISALHVINIDKLINTIKNYLHKDVVTDYFRQKAEKEDKFVITEIIREQCLLNLNHEVPHGVGVEIDESKYNQEANHWIIKASIIIEKNSHKPIIIGQNGTMIKKISMGARKQLHEIYDCHISLTIFVKVENNWRDNNNIIKSLGYKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ10</accession>
    <name>Q9PQ10_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689019.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU480"/>
    <dbReference type="EnsemblBacteria" id="AAF30892">
        <property type="protein sequence ID" value="AAF30892"/>
        <property type="gene ID" value="UU480"/>
    </dbReference>
    <dbReference type="GeneID" id="29672586"/>
    <dbReference type="KEGG" id="uur:UU480"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.496"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526693_0_0_14"/>
    <dbReference type="OMA" id="AAYMLNT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004330938" evidence="2">
        <location>
            <begin position="29"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="539" mass="58890" checksum="57F5B1631E42E0A3" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ13</accession>
    <name>Q9PQ13_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenine specific DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mod</name>
        <name evidence="4" type="ordered locus">UU477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891791.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU477"/>
    <dbReference type="REBASE" id="4894">
        <property type="entry name" value="M.UurORF477P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30889">
        <property type="protein sequence ID" value="AAF30889"/>
        <property type="gene ID" value="UU477"/>
    </dbReference>
    <dbReference type="GeneID" id="29672685"/>
    <dbReference type="KEGG" id="uur:UU477"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.493"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690419_0_0_14"/>
    <dbReference type="OMA" id="KQYQFVK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="360" mass="41977" checksum="B6006E0E0C3852A1" modified="2000-10-01" version="1">MMNERLKLAKNLLKNDGVIFVSIDDNEQAYLKVLMDEIFGEENFVTNFIWQKKSGGGLNKLIYEGHEYILCYSKNNYNFCLSEKNKKMSGFIKYKDKNNNSFFINSDIIRNNFGKKDNKFEHRNKAYEDLSKEDKEKWNLKLDNKNYILVPFKKEPGKHLVAKIFNDERKTTYSIIKLPFTFVSGIWTKDGNNEVDSLNIDFQNPKPIQLIMHLLDLHSNKNARVLDFFAGSGTTGHAVLELNKEDGGNRTFTLITNNENQIGTNVCYERLYRINNGIGTKNEIDFDWVSKNKPYLNKLNVYDLKYFDTNPIEVDNSKIKKVFAKMLVDFNNTSQSSLFENNQRELLINLSTLKPIEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ22</accession>
    <name>Q9PQ22_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688742.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU468"/>
    <dbReference type="EnsemblBacteria" id="AAF30880">
        <property type="protein sequence ID" value="AAF30880"/>
        <property type="gene ID" value="UU468"/>
    </dbReference>
    <dbReference type="GeneID" id="29672292"/>
    <dbReference type="KEGG" id="uur:UU468"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.484"/>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017878_0_2_14"/>
    <dbReference type="OMA" id="HYNEVQD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019988">
        <property type="entry name" value="GTP-bd_ribosome_bgen_YqeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03597">
        <property type="entry name" value="GTPase_YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENGC_GTPASE" evidence="1">
        <location>
            <begin position="89"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="361" mass="41161" checksum="AF9E4F127EBD5472" modified="2000-10-01" version="1">MITNKKCKGCGAFLNDQINTIGYTPKINETKTNLCQRCFKLIHYNKLEKVSTNLNQSIKETINTLNFSNLQIFAVLDILDLEHTIIDELKEYQNKIIFLVNKIDLLPQRYNSELVNENVVKTLINHGFIDPKIIYVSTHSNTSLKKVMDYIKNATNKKQKSIFFGKSNVGKSSLINALLALNKIKTKLTISSYTNTTINLNKINIQEHQILDAPGVCFDENILNYVRDEDNKSIMISYGAKAINYQINPQQALMISGLVGIQYLKGQKTTFTLYVSSQLDIHRCKLENFIMNFNKRYLLAKFNYLNQDLEFVDHLITLNKDQKTNICIAGLGLLVINAHAEQICIRLPKSVGLKVAKYAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ28</accession>
    <name>Q9PQ28_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU462"/>
    <dbReference type="EnsemblBacteria" id="AAF30874">
        <property type="protein sequence ID" value="AAF30874"/>
        <property type="gene ID" value="UU462"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU462"/>
    <dbReference type="HOGENOM" id="CLU_1022865_0_0_14"/>
    <dbReference type="OMA" id="IFIMAKI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="272" mass="32050" checksum="71B0270C7D459A14" modified="2000-10-01" version="1">MNLRHSKTTWFRKPFETNTRFKSPLLYKFLITSFFVVIPMIVFFILYGEINLLGFNGIIGVNGRWYGKGFKLDENQQWIVGVKDFYHWNPIVYDQLKPKPGPLMIERMQKLVNEITNQYNHGVEFGTNIISSYPVWVAMFSTLGLAVIVCIIFAFSTPKIRWDILTPVVSCWFGMFILIISGFIPSQIWGYLVRFLILVVAFILPIFIMTKITNAIMNRSKHFETYAADLYNELKDSEQYYNEFNKKRLELKKRNKANERIKYKVEDDQKGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-08" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ32</accession>
    <name>SYFA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber>6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName>PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pheS</name>
        <name type="ordered locus">UU458</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689319.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ32"/>
    <dbReference type="SMR" id="Q9PQ32"/>
    <dbReference type="STRING" id="273119.UU458"/>
    <dbReference type="EnsemblBacteria" id="AAF30870">
        <property type="protein sequence ID" value="AAF30870"/>
        <property type="gene ID" value="UU458"/>
    </dbReference>
    <dbReference type="GeneID" id="29672675"/>
    <dbReference type="KEGG" id="uur:UU458"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_14"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000126790" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="333" mass="38713" checksum="5C4E3530FA34FECF" modified="2000-10-01" version="1">MDVINLIKNLKQILRTANNERHLIELKNIFVKQHLLPLYDELKKSANKKEMGLLINNFKQQIEFVTDQILKELNDKDDQVDLKKWTNKTLFAPFINNGHHHILNSIIDDIASFFKKLNFEIVSGSEVVSPIYNFDHLNIDENHPARASADSFFINSIKMLRTHCTTTTAQFLENNVNKDIRIMSFGNVYRKDDDDATHSHQFNQVDFVWVKEGLTVANLKWLIDSLIKYLFGQNLKTRYRLSFFPFTEPSFEVDVQCFKCDLKGCAVCKKSTWIEIMGTGMLHENVLKAANINDIRTGMAFGVGIDRIAMLKYEIDDIRYLYSNNFKFNAQIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ38</accession>
    <name>SYP_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">UU452</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688815.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ38"/>
    <dbReference type="SMR" id="Q9PQ38"/>
    <dbReference type="STRING" id="273119.UU452"/>
    <dbReference type="EnsemblBacteria" id="AAF30864">
        <property type="protein sequence ID" value="AAF30864"/>
        <property type="gene ID" value="UU452"/>
    </dbReference>
    <dbReference type="GeneID" id="29672583"/>
    <dbReference type="KEGG" id="uur:UU452"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_14"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000249154" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <sequence length="472" mass="54370" checksum="CB514DA9C06A329A" modified="2000-10-01" version="1">MSKKLEKITTRKENFADWYTSIVNNAKLIQYTDIKGMMVFQPNAWAIWEAIKNQIDVEFKKHGVRNLAMPTLIPLSEFQKEKDHIEGFAPELFMVNQIGDKKLDNSYAIRPTSEILFCNYFKNIVNSYNDLPIKNNQWCSVMRAEKTTRPFLRNAEFHWQELHAIFASENEADSFAKVILDVYTDFVQNYLCIPVIKGLKTPWERFAGAQKTYTIEAMMQDGQALQSATSHYLGQFFAKAYDIKFQGQDNQMHYVHQMSAGLSTRIIGALIMVHADDQGLILPPDIAFNQIAILTIFSNKNPQLLKISQQICEQLNNYRLFEDHSDKGIGYKLAQQEIEGTPICILVGAKELVNQQVVIVRRDTHEKINVDLTDLKLIIPKLLADIKRNIYEKAKKDLEDSIVFVNNIEELKQVIAQNKMAKAFFDGTKEDDEQIKLLTNASTRCIFDETQNGQCFYTNKKTNKLTLFARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ39</accession>
    <name>Q9PQ39_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688417.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU451"/>
    <dbReference type="EnsemblBacteria" id="AAF30863">
        <property type="protein sequence ID" value="AAF30863"/>
        <property type="gene ID" value="UU451"/>
    </dbReference>
    <dbReference type="GeneID" id="29672577"/>
    <dbReference type="KEGG" id="uur:UU451"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.467"/>
    <dbReference type="HOGENOM" id="CLU_831398_0_0_14"/>
    <dbReference type="OMA" id="FTHNEYF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="338" mass="39465" checksum="EC2EA8D5D965E7E3" modified="2000-10-01" version="1">MGLFSKKNKLNQKLTEDKNINITDVLDNNKDIYQLYDETIVTKKVKVRCKNCGVFMWVDYTKTIKSLRNLALTNIQQEQIPVMDEPQILQDCNDLSSAPVNNQEDDIVNEHESTPIEPLHEEVEPEPIKNENQSNEEFIQENIVAPVDEVDNSVKEHTPFTPVSFEFEEPVFENIYSNQKVYAENLFLESLFSEKESLINDDQNDFSWLSKYVSVWNKRDEAELAQLVYDECLLAPQSSVFPNNEYFIEEEYEHIDPDNHHNKHKAQRHHRGHDLIVKKNGKEQIEKAIDDVLPINNGLDKKQQLLLKTVLIEEEFQSDPISKKTWWETESANKSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ40</accession>
    <name>Q9PQ40_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">UU450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891778.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU450"/>
    <dbReference type="EnsemblBacteria" id="AAF30862">
        <property type="protein sequence ID" value="AAF30862"/>
        <property type="gene ID" value="UU450"/>
    </dbReference>
    <dbReference type="GeneID" id="29672552"/>
    <dbReference type="KEGG" id="uur:UU450"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.466"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629808_0_0_14"/>
    <dbReference type="OMA" id="FKRVFFN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="387" mass="45526" checksum="1D847354AB44A1CD" modified="2000-10-01" version="1">MDNNINEKTSFWTKKNICFLIIGLIVCLLMIIISILFILDIDFQNLFIKINHSLKTIKLAILWLLILISFIFFRAFMFIVIAVIDTYKNQIKIAWWKWILYSFSLIFLNAVTPFSVGSEPFSIYFLNKNGYHNLKKVSALLLVSSTFYELGQVIVTVPSFIYINYELITYAVNNKTSLPFYYYLAVVGIIADLCMTAIYFVLGFSKKLHFRSVLIYNWVKKLFKLKYLTKIELIQKNNQNISFKAFYLYYFKTLRVSLLAFVIGVVYNIGIYALMYISYRLVEPKPHNIFFDLFNYTNIAVTATNFVPLPGSEGSIQFMLRVFLTNDQNQIRYAMNWLSTQDINNIIFIWRMFSIYLGSLIGMFGFGYFLIFDLYKFIKKAKVDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ48</accession>
    <name>Q9PQ48_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891774.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU442"/>
    <dbReference type="EnsemblBacteria" id="AAF30854">
        <property type="protein sequence ID" value="AAF30854"/>
        <property type="gene ID" value="UU442"/>
    </dbReference>
    <dbReference type="GeneID" id="29672488"/>
    <dbReference type="KEGG" id="uur:UU442"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.458"/>
    <dbReference type="HOGENOM" id="CLU_690668_0_0_14"/>
    <dbReference type="OMA" id="NDRENWE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331065" evidence="1">
        <location>
            <begin position="28"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="416" mass="48920" checksum="65D655F7C371CE2A" modified="2000-10-01" version="1">MKFKKKAILLSTISLSSMVLGSFSLLAKNKSQQTISSKLNQQVNLVDNQNQNKISYSVIEIDESNKDYFKDKLIIRLIFNTTKASKTEIFEQHLKIKTWIKNAKISGVDQYNEFDYLPFMDLIIFNNKLDLKQLESLSNSDFINQVIINKIKFILFNKKIDQKPMAVFGECKNLVLKNEWGFDQDVGEFCQIDSSSGTSFEPVYSKDLLELREEFIENVEDRLSDEFFADFYDNTNLFEQTPTPNDHLLIKTNPIKDDFESLLSKKSGLQYKIMRLVYQHEHGKVIKTLPVNALTFLNHEDLKFEELYSGNYRFTGIEYWDKENKIWVFEELINHNEQYYQMQVVFNNNITVHDLISKVYFDAHFNKPQEESTSQSLTLSLNPNFNNINKDESIEIKLMNLNDRENWESPSLFTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ63</accession>
    <name>Q9PQ63_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891766.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU425"/>
    <dbReference type="EnsemblBacteria" id="AAF30837">
        <property type="protein sequence ID" value="AAF30837"/>
        <property type="gene ID" value="UU425"/>
    </dbReference>
    <dbReference type="GeneID" id="29672181"/>
    <dbReference type="KEGG" id="uur:UU425"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.441"/>
    <dbReference type="HOGENOM" id="CLU_1229471_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="225" mass="26989" checksum="9255290F83C7C54A" modified="2000-10-01" version="1">MATSNDLLIYSNLKQTPKYQIDNKKLKEDFVKNNNWLSENVDYHLSIFKDIKYDFYLSHWCYQYWIDQNRLDVILKLIYNANKIILYPNGNAELYYVANYYAQAIKNLIREDPHLSKQKINDHLNNFINMKSFLEAKNYFSSQLNNNKDWLTVFVLNKLFKIFTIGESWVDSKYFSFNKELMPKSYKIRTNYASVLNSLNLSLDAKNQFKKKILSTLLEYTIKHF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ73</accession>
    <name>Y416_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU416</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU416</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To M.pneumoniae MPN377.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688799.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ73"/>
    <dbReference type="STRING" id="273119.UU416"/>
    <dbReference type="EnsemblBacteria" id="AAF30827">
        <property type="protein sequence ID" value="AAF30827"/>
        <property type="gene ID" value="UU416"/>
    </dbReference>
    <dbReference type="GeneID" id="29672561"/>
    <dbReference type="KEGG" id="uur:UU416"/>
    <dbReference type="HOGENOM" id="CLU_2756672_0_0_14"/>
    <dbReference type="OMA" id="YEQHSIE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000210671" description="Uncharacterized protein UU416">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="70" mass="8569" checksum="CC92B28EE53F95FE" modified="2000-10-01" version="1">MSDKKSDFEKLFERSKVQETSIFDINDIDEQKPYEEHSIEELSYILEYEKIDKKTREKIKKIIKEKQQNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ78</accession>
    <name>TSAD_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="1">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaD</name>
        <name type="synonym">gcp</name>
        <name type="ordered locus">UU411</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689092.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ78"/>
    <dbReference type="SMR" id="Q9PQ78"/>
    <dbReference type="STRING" id="273119.UU411"/>
    <dbReference type="EnsemblBacteria" id="AAF30822">
        <property type="protein sequence ID" value="AAF30822"/>
        <property type="gene ID" value="UU411"/>
    </dbReference>
    <dbReference type="GeneID" id="29672458"/>
    <dbReference type="KEGG" id="uur:UU411"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_1_14"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000303605" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <sequence length="320" mass="35448" checksum="9918A1344081EA67" modified="2000-10-01" version="1">MNDNYLILSIESSCDETSLALFENNKLIAHKISSSASIQSLHGGVVPELASRYHEQNINHLFNEILNETKINPLTITHVAYTAMPGLPGCLHVGKVFAKQLAVLINAELVPINHLHAHVFSASINQNLTFPFLGLVVSGGESCIYLVNDYDEIKVLNQTHDDAIGECYDKIARVLGWKYPGGPIIDKNYQENLATLEFIKSQPAAKDFSFSGLKTAVINYIHNAKQKKISFDPVVVASSFQKFAINEIIKKIKYYLNLYKLNHLAIGGGVSANSLLRKKIQSLDVISYIPEMIYTGDNAAMIGAYAYALIKNHKKSILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ80</accession>
    <name>Q9PQ80_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689037.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU409"/>
    <dbReference type="EnsemblBacteria" id="AAF30820">
        <property type="protein sequence ID" value="AAF30820"/>
        <property type="gene ID" value="UU409"/>
    </dbReference>
    <dbReference type="GeneID" id="29672417"/>
    <dbReference type="KEGG" id="uur:UU409"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.425"/>
    <dbReference type="eggNOG" id="ENOG502ZU2R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908945_0_0_14"/>
    <dbReference type="OMA" id="GINANDW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035319">
        <property type="entry name" value="DUF5378"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17349">
        <property type="entry name" value="DUF5378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="306" mass="36424" checksum="5166370D4598B321" modified="2000-10-01" version="1">MSANYFLIGLTIFCITCIGLANFLIKPIQIKKHNWLTWNYFINTKWIINTLISISFLIYFCCLRWAPNIHVFFINHIEIINVLRDKFSDDIDLYEASITISRTFLLDWCPCFSVLISCVAIFDKKQIIINHLGFLCFCFGLLTIIGGLIGDEPIRWNRLITYIFIGDKPNPIYFSLHFYLCLFGFYLFVNTRKTIKIYWIYIIIHIILITYIIYVNVMILIFNIKNNASGFSFGDWYSPIYAQYGTVAQFLQLNYRLNALIMCLFMYAIFIVGYLIRYHLQKIYINKYNIKYSQERNYFAYVKNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ81</accession>
    <name>Q9PQ81_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688772.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU408"/>
    <dbReference type="EnsemblBacteria" id="AAF30819">
        <property type="protein sequence ID" value="AAF30819"/>
        <property type="gene ID" value="UU408"/>
    </dbReference>
    <dbReference type="GeneID" id="29672402"/>
    <dbReference type="KEGG" id="uur:UU408"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.424"/>
    <dbReference type="HOGENOM" id="CLU_1748874_0_0_14"/>
    <dbReference type="OMA" id="HEHCENE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="149" mass="18189" checksum="3D3D51D1AFED2C45" modified="2000-10-01" version="1">MSKIVDNIDINALRINHYEEWEQNHIIKVINAYRHHESKKEKFKMIHELIKNHQMHLTKLIPLFDVSISGYYKWLEDLKIDQVCPIKKRNMDLIEKICKSHKHYIGCRKIQKILETQYNVKLNYKTINLYMNKMDLCKPCHHEHHEKKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ88</accession>
    <name>MNMA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="1">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmA</name>
        <name type="synonym">trmU</name>
        <name type="ordered locus">UU402</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688685.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ88"/>
    <dbReference type="SMR" id="Q9PQ88"/>
    <dbReference type="STRING" id="273119.UU402"/>
    <dbReference type="EnsemblBacteria" id="AAF30812">
        <property type="protein sequence ID" value="AAF30812"/>
        <property type="gene ID" value="UU402"/>
    </dbReference>
    <dbReference type="GeneID" id="29672313"/>
    <dbReference type="KEGG" id="uur:UU402"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_1_0_14"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000121696" description="tRNA-specific 2-thiouridylase MnmA">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with target base in tRNA" evidence="1">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="1">
        <location>
            <begin position="113"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <sequence length="385" mass="44278" checksum="19B2BCEB87152183" modified="2000-10-01" version="1">MEVKVKKRVVVGLSGGVDSSVSALLLKQEGYEVIGLFMSNWDTIANFENNHEFNKTHQGCESELDYQDAQAVAQKIGIPLYRVEFIKEYWDNVFEYFLSEYQKNRTPNPDILCNQFIKFDSFLNYAKNELQADYIAMGHYARVKHDRNSSFLLKAIDTNKDQTYFLCNLNQNQLQNVLFPIGHLTKLQVRAIAKKHGLITANKKDSTGICFIGERNFKTFLQNYIPNQPGQIINIVNNQIIGHHIGTMYYTIGQRKGLNLGGMNERMFVCDKDIDKKIIYVAPSSFEKQYLISTQALIENINFIEPYNPQIPIMVRFRHRQDLIIVNDFLPIKNTKNVLINYESARAITPGQYAVFYQNDHCIGGGIVSKTNIGHQKVDFLVYKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ93</accession>
    <name>RNH3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Ribonuclease HIII</fullName>
            <shortName>RNase HIII</shortName>
            <ecNumber>3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rnhC</name>
        <name type="ordered locus">UU397</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. RnhC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689032.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ93"/>
    <dbReference type="SMR" id="Q9PQ93"/>
    <dbReference type="STRING" id="273119.UU397"/>
    <dbReference type="EnsemblBacteria" id="AAF30807">
        <property type="protein sequence ID" value="AAF30807"/>
        <property type="gene ID" value="UU397"/>
    </dbReference>
    <dbReference type="GeneID" id="29672376"/>
    <dbReference type="KEGG" id="uur:UU397"/>
    <dbReference type="eggNOG" id="COG1039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059546_1_0_14"/>
    <dbReference type="OMA" id="TGDYFGP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00053">
        <property type="entry name" value="RNase_HIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004641">
        <property type="entry name" value="RNase_HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037748">
        <property type="entry name" value="RnhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000111709" description="Ribonuclease HIII">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="2">
        <location>
            <begin position="101"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="316" mass="36418" checksum="E1BD5366CEA0F35B" modified="2000-10-01" version="1">MAIVSVKLTSNQVDKFLILWRPYLVHNNHNYAKYTFKIDGTLIIIYNTNTCTINTHDINSFLNTFLKREDLTLFNVIKQQVNTKKNNQNVMSQSEIYESAQVIIGSDEVGVGDLFGGIVVCAVSLKKSDFKKINHLKIIDSKKLNDQQMQEIYQQIKNQISYTIVSYNPKEYNELIKEYNNAHILKTILHYKALQSEIHKHAKYSIFSVVDAFSSLKNWNQYLQKVNFQPYEPNLLIPKAESIYTSVALASIIARVMFLKMIAIIEEQFNVKIPLGSSNPLVNDVASNIFQKFGLKILKQVAKEHFSNFQQIIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ95</accession>
    <name>Q9PQ95_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689080.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU395"/>
    <dbReference type="EnsemblBacteria" id="AAF30805">
        <property type="protein sequence ID" value="AAF30805"/>
        <property type="gene ID" value="UU395"/>
    </dbReference>
    <dbReference type="GeneID" id="29672319"/>
    <dbReference type="KEGG" id="uur:UU395"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.410"/>
    <dbReference type="HOGENOM" id="CLU_186212_0_0_14"/>
    <dbReference type="OMA" id="GITNIAM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="93" mass="10264" checksum="A66CC755E81A0204" modified="2000-10-01" version="1">MQRIINKNMIYGGFMPLVSGALGFWNKMLFGTIIANTAISMIGGITNIVMASSSQQNHDSQDIDSIKIETINVDMSTIVGPKIPYMNIYYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ96</accession>
    <name>Q9PQ96_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">UU394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688558.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU394"/>
    <dbReference type="EnsemblBacteria" id="AAF30804">
        <property type="protein sequence ID" value="AAF30804"/>
        <property type="gene ID" value="UU394"/>
    </dbReference>
    <dbReference type="GeneID" id="29672353"/>
    <dbReference type="KEGG" id="uur:UU394"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.409"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2319294_0_0_14"/>
    <dbReference type="OMA" id="EKEQEYT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="99" mass="11972" checksum="02CA9DCB68CAA4FE" modified="2000-10-01" version="1">MVNDNKINEYKNKKFVANKVGYDPESVDVFLDELINELEIFINEHKNAILKIEELNEYKRKFEKEREYTTSLNNFIDLLEKVVDKKSTFDVWEKRPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB0</accession>
    <name>Q9PQB0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688984.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU380"/>
    <dbReference type="EnsemblBacteria" id="AAF30790">
        <property type="protein sequence ID" value="AAF30790"/>
        <property type="gene ID" value="UU380"/>
    </dbReference>
    <dbReference type="GeneID" id="29672585"/>
    <dbReference type="KEGG" id="uur:UU380"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.395"/>
    <dbReference type="eggNOG" id="COG2249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1585761_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="168" mass="20150" checksum="1DB9F54A56E02170" modified="2000-10-01" version="1">MKKTLVLYARVCPTKSFHTQQIFEAFQKQTNFVCVNLDANQPFDVSKEQEFILGFDRIILLFTLNWYNIPWSLSRYFIEVWRTFPFSLENKEVYKIITTGANQDFYEKKDPNINNISVEEYLNNVNGMLKKLRASIQKSFYYYGAINQDQMRLNQFVNELIKYFKNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB7</accession>
    <name>Q9PQB7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU374"/>
    <dbReference type="EnsemblBacteria" id="AAF30783">
        <property type="protein sequence ID" value="AAF30783"/>
        <property type="gene ID" value="UU374"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU374"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.387"/>
    <dbReference type="eggNOG" id="ENOG50348J8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194527_0_0_14"/>
    <dbReference type="OMA" id="HDISKEF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="75" mass="9192" checksum="E1D1D162E2D5B89B" modified="2000-10-01" version="1">MGRQLREDEWLSIFFWYEQYLNYDISKEFLSYKYCEISNGRQLNKYSLKLIKTKYKLYNLGMNINSQTGKATKKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC0</accession>
    <name>SYL_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="1">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuS</name>
        <name type="ordered locus">UU371</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891746.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQC0"/>
    <dbReference type="SMR" id="Q9PQC0"/>
    <dbReference type="STRING" id="273119.UU371"/>
    <dbReference type="EnsemblBacteria" id="AAF30780">
        <property type="protein sequence ID" value="AAF30780"/>
        <property type="gene ID" value="UU371"/>
    </dbReference>
    <dbReference type="GeneID" id="29672253"/>
    <dbReference type="KEGG" id="uur:UU371"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.385"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_14"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152112" description="Leucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="580"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <sequence length="806" mass="93299" checksum="B5F61AFE314A41A9" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC1</accession>
    <name>YQGF_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU370</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YqgF nuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688766.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQC1"/>
    <dbReference type="SMR" id="Q9PQC1"/>
    <dbReference type="STRING" id="273119.UU370"/>
    <dbReference type="EnsemblBacteria" id="AAF30779">
        <property type="protein sequence ID" value="AAF30779"/>
        <property type="gene ID" value="UU370"/>
    </dbReference>
    <dbReference type="GeneID" id="29672599"/>
    <dbReference type="KEGG" id="uur:UU370"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_2_14"/>
    <dbReference type="OMA" id="VKWDERF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000172168" description="Putative pre-16S rRNA nuclease">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <sequence length="147" mass="16841" checksum="7CA7FE3E3D0D7278" modified="2000-10-01" version="1">MRKLALDLGTKSCGFAISDLLGIIASGLDNFIYEENDFTAVLAKIDEIMINYHHEIDTIVLGYPTNVYDGSKNERTYLIESFYALLKQHFLNHEKIKIVYEDERFSTKIATQRLKNSCVKAAKIKKVKDKMSAVVILESYLSKNHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC3</accession>
    <name>Q9PQC3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymidine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deoA</name>
        <name evidence="6" type="ordered locus">UU368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689156.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU368"/>
    <dbReference type="EnsemblBacteria" id="AAF30777">
        <property type="protein sequence ID" value="AAF30777"/>
        <property type="gene ID" value="UU368"/>
    </dbReference>
    <dbReference type="GeneID" id="29672325"/>
    <dbReference type="KEGG" id="uur:UU368"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.382"/>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_14"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="345"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="433" mass="48678" checksum="88D8560D27FF2A72" modified="2000-10-01" version="1">MLNVVEIISKKKNNIELSEQEIKFVYDGFVNKTIPDYQMAAFLMAVNFCGYSENEQYYATKAMVESGKLLDLRVENKIVVDKHSSGGVGDKVSIILTPLLSALGLYVGKMSGRGLGHTGGTVDKLESLNLNLDFDLKTYMNQLKDNGLLLTGQSDDMVVADKYIYALRDVTATSDVFDLMIGSIMAKKLALITDYIFLDVKVGEGAFCKNVAQAESLATKMLKLSKKFNRNTIIHLTNMDQPLGKAIGNAIEIKESMDYLLGKPVPQDLYDLINQFALDILIDTKFAKNKEDAQSKIDNVIKNGLAYQKFVNWVKWYKGDYISLENDTYFNPKYKLEILAKQDGYLDFKSTKELGMIAVDLKAGRKVKTDQLDFQAGIYLNKKNNDFVKTNEVIATLYASEPINDEVVNKYHNNVVYLKTPKQIAPSIIKVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC7</accession>
    <name>Q9PQC7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phosphatidylglycerophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">psgA</name>
        <name evidence="13" type="ordered locus">UU364</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891744.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU364"/>
    <dbReference type="EnsemblBacteria" id="AAF30773">
        <property type="protein sequence ID" value="AAF30773"/>
        <property type="gene ID" value="UU364"/>
    </dbReference>
    <dbReference type="GeneID" id="29672227"/>
    <dbReference type="KEGG" id="uur:UU364"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.378"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_3_14"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAF30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="218" mass="24643" checksum="F4D65A8214501FFC" modified="2000-10-01" version="1">MAKLNFKKNISSSPFFRNIPNIITIFRIFLALICIILLLVDFYTKNLNIVYEVLDANISALRLSATIIFIIAAFSDFLDGYIARKYNLVSNLGKILDPISDKILVNGVLICLTLDHTALAYLTIINILRDIFIDGLRMFASSKKIIIPANIFGKIKSILLFISICFILFLLSLTSSWKNVYLFNIPLFFATSLSVISGIIYYINFYKGVKKRGSITKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE0</accession>
    <name>GCH1L_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU351</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688492.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQE0"/>
    <dbReference type="SMR" id="Q9PQE0"/>
    <dbReference type="STRING" id="273119.UU351"/>
    <dbReference type="EnsemblBacteria" id="AAF30760">
        <property type="protein sequence ID" value="AAF30760"/>
        <property type="gene ID" value="UU351"/>
    </dbReference>
    <dbReference type="GeneID" id="29672425"/>
    <dbReference type="KEGG" id="uur:UU351"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_2_1_14"/>
    <dbReference type="OMA" id="ENKEEWD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000147342" description="GTP cyclohydrolase 1 type 2 homolog">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AFP6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="262" mass="30116" checksum="6CA891E4E194782A" modified="2000-10-01" version="1">MKKMDIKAQDILNFLTKKYDLSKAEAWDKNGLFFDEQQTINNVQIALDITDDVVNDAILNNANLIISHHPLFTNQDSNDEVNYFVNIDLIEKIKKNKISLIHLHTAFDASANGMSMQMAKRLGLLNLKQDEQNPYLVVGELKLGVSVDYISRIIKQKFLSPIIKYNNVFRLETNLKKIGIIGGSGYKFADDAFNRYQLDMLITSDLKYHNWLDAQAKKQNIIDMNHLSESIFIDVIYDELTKFYGNDANLNKSLSIIKINYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF1</accession>
    <name>Q9PQF1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU340"/>
    <dbReference type="EnsemblBacteria" id="AAF30749">
        <property type="protein sequence ID" value="AAF30749"/>
        <property type="gene ID" value="UU340"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU340"/>
    <dbReference type="eggNOG" id="COG1881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675821_0_0_14"/>
    <dbReference type="OMA" id="EYHVIED"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="388" mass="44563" checksum="971B2331E315D94D" modified="2000-10-01" version="1">MYKLIFNLCIYIKNKGKFEYMVENKFLKQIKEGEQIKIEIKGLDKFNNFDEQNYGLNNISPQIRWSPVLETASYAVAIIDYEAVGGAPFVHWYALNIFEPELALNVANLGYANLYQGENSTSKHFSHSILDANYQTDIANNYFPPCPPNKSHKYEIKVYAVHHKLSTNRNNILYLDDFEAKLNEAKIIATGSTYVCAPQISFEDDKLIIGSLEHKHPYLFANCENEYHVIEDVIVTDINKNIYSENQLDNFKDLEQAKIKIIDSSDALSYAVIITSNHLFKKFGRPVVNYAHVIEKKTNKRIKFNNSYKLNHAFSEISPSKYDHLGNELLILEDKDANFESGLFTIHVFGLNKKIKYLNKIDSVANSISDLFEMISGSVISYKAKLFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF9</accession>
    <name>URK_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridine kinase</fullName>
            <ecNumber evidence="1">2.7.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine monophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">udk</name>
        <name type="ordered locus">UU332</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + uridine = ADP + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine = ADP + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688441.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQF9"/>
    <dbReference type="SMR" id="Q9PQF9"/>
    <dbReference type="STRING" id="273119.UU332"/>
    <dbReference type="EnsemblBacteria" id="AAF30741">
        <property type="protein sequence ID" value="AAF30741"/>
        <property type="gene ID" value="UU332"/>
    </dbReference>
    <dbReference type="GeneID" id="29672380"/>
    <dbReference type="KEGG" id="uur:UU332"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_14"/>
    <dbReference type="OMA" id="TTLKPMH"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00551">
        <property type="entry name" value="Uridine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026008">
        <property type="entry name" value="Uridine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000164505" description="Uridine kinase">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00551"/>
        </source>
    </evidence>
    <sequence length="207" mass="24178" checksum="6280629824E15011" modified="2000-10-01" version="1">MNTKSPILILIAGASGSGKTTFANEIIARIPKNTTSVVICQDSYYISNSQLNKKERRLINYDHPSSFEWELMREQLSDIKKRKKIKVPIYDYKTEIRLDKTIDISDVDVIVLEGIYAIYDDVINQIADLKIFIETPKDECLIRRILRDVNERNRSFESVITQWRSTVSPMYDQFVEPSKKNANVSVLWNEHNRVALHLIHKWINNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG8</accession>
    <name>Q9PQG8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688751.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU323"/>
    <dbReference type="EnsemblBacteria" id="AAF30732">
        <property type="protein sequence ID" value="AAF30732"/>
        <property type="gene ID" value="UU323"/>
    </dbReference>
    <dbReference type="GeneID" id="29672415"/>
    <dbReference type="KEGG" id="uur:UU323"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.336"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199376_0_0_14"/>
    <dbReference type="OMA" id="RHKANIL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="231" mass="28126" checksum="723F5E5A15B07AB6" modified="2000-10-01" version="1">MLSFVKELNFEINQKKYFIKIYLQPRIKYIKIKIINHQIVCLINHLKLINIAEEFIKNNKLKILKIYENDLKKIKYDEQSLDWIILLGIKFTTIKIKNNNFHCQFNFQKQIIYLYDQNQNLTNTKLLYQKILIYLAEIIFPQIIKNAQNITTLTVKKYVFGFYKSQWGVYNKIKHTIGLSYFLVHYDQDIINYVVIHELAHIKYQHHQKSFWDFVLKYCKNAKIYNNQLKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-13" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI1</accession>
    <name>RS20_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsT</name>
        <name evidence="1" type="synonym">rps20</name>
        <name type="ordered locus">UU310</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688746.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQI1"/>
    <dbReference type="SMR" id="Q9PQI1"/>
    <dbReference type="STRING" id="273119.UU310"/>
    <dbReference type="EnsemblBacteria" id="AAF30719">
        <property type="protein sequence ID" value="AAF30719"/>
        <property type="gene ID" value="UU310"/>
    </dbReference>
    <dbReference type="GeneID" id="29672499"/>
    <dbReference type="KEGG" id="uur:UU310"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_1_0_14"/>
    <dbReference type="OMA" id="KQNRARH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000168055" description="30S ribosomal protein S20">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="84" mass="9584" checksum="DEC828233562430D" modified="2000-10-01" version="1">MANIVSNEKTYRHTQKVRKENHAKMSKLRTIVKKTRSSNEQAQLNEAYKVIDTTASKGVIHKNKANRLKSRTAKAFKTNLEVTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI5</accession>
    <name>END4_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable endonuclease 4</fullName>
            <ecNumber evidence="1">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfo</name>
        <name type="ordered locus">UU306</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891729.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQI5"/>
    <dbReference type="SMR" id="Q9PQI5"/>
    <dbReference type="STRING" id="273119.UU306"/>
    <dbReference type="EnsemblBacteria" id="AAF30715">
        <property type="protein sequence ID" value="AAF30715"/>
        <property type="gene ID" value="UU306"/>
    </dbReference>
    <dbReference type="GeneID" id="29672536"/>
    <dbReference type="KEGG" id="uur:UU306"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.319"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_4_1_14"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000190883" description="Probable endonuclease 4">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <sequence length="303" mass="34704" checksum="7AD4284C27D6877F" modified="2000-10-01" version="1">MDKYNLIIGSHVSLKAKDFFYGSVKEALSYGSNTFMVYTGAPQNTKRQPIKSFKIEEAHNLLKKHNINLDDLIVHAPYIINPCSSKKNVRELAKEFLIQEIQRTESMGITKLVLHPGSRLEQNEDIALEQVYTMLNDIFSTINTNVIVCLETMAGKGSEIGVNIKQLKTIIDNVHSKKNIGVCLDTCHMNDSGLILDYYNFNQYLKEFDAQIGINYIKVLHINDSKNPCGANKDRHENLGYGTIGFANLINIIYHPLLNNIPKILETPWFNVNDELIPLYKHEIKMIRDCKWYDIKNKLLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI8</accession>
    <name>Q9PQI8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU303"/>
    <dbReference type="EnsemblBacteria" id="AAF30712">
        <property type="protein sequence ID" value="AAF30712"/>
        <property type="gene ID" value="UU303"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU303"/>
    <dbReference type="HOGENOM" id="CLU_1601993_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19419" checksum="FD048106FFE9C868" modified="2000-10-01" version="1">MQEGDFYATDRDPFLTYWKELKPSFYAKKSVYIAFLTIIIAFAVSIIGFVNYFSLKIALEQTQKATLEVQKQKEEQKNQLSNGVYFDQDLNLLNEYDKLVLYQKNNLSSIVFLAINDQEQILMQKDQVVVNSLNIEQKVKYREQATRIVFEKQAEHNDHLVTSGNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ3</accession>
    <name>EFP_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor P</fullName>
            <shortName>EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">efp</name>
        <name type="ordered locus">UU298</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text>Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688853.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQJ3"/>
    <dbReference type="SMR" id="Q9PQJ3"/>
    <dbReference type="STRING" id="273119.UU298"/>
    <dbReference type="EnsemblBacteria" id="AAF30707">
        <property type="protein sequence ID" value="AAF30707"/>
        <property type="gene ID" value="UU298"/>
    </dbReference>
    <dbReference type="GeneID" id="29672456"/>
    <dbReference type="KEGG" id="uur:UU298"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_2_1_14"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000094363" description="Elongation factor P">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="188" mass="21221" checksum="6EE4A873CF7F7E15" modified="2000-10-01" version="1">MATIIQAKDLRAGHTFLYKGNIYQVIENSFNKTAMREGIVKCKVKNLRTGAITIEVLTGEKLEQAVIEKSKMTFSYDDGSGYVFMDNDTYEQISIPYSQLSWEKNFIEEGTEVSVMRYDGELMGVSLPDQLVVTIIEAEEAVQGNSVQNATKRAWLESKWEFQVPQFIKSGEKVIINPSNGQYVGRAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-04" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ6</accession>
    <name>Y295_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein UU295</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU295</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688835.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQJ6"/>
    <dbReference type="SMR" id="Q9PQJ6"/>
    <dbReference type="STRING" id="273119.UU295"/>
    <dbReference type="EnsemblBacteria" id="AAF30704">
        <property type="protein sequence ID" value="AAF30704"/>
        <property type="gene ID" value="UU295"/>
    </dbReference>
    <dbReference type="GeneID" id="29672584"/>
    <dbReference type="KEGG" id="uur:UU295"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_14"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000175925" description="Probable transcriptional regulatory protein UU295">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <sequence length="236" mass="26782" checksum="D281ED8C64FEB880" modified="2000-10-01" version="1">MPRKHLIASGINKKQQQQAKIWMKCAKEIKAAAKMGGPNPEANSRLKVAIERALNNNLSRDSIERNINGASKDIDNLKELTYEGYGPNGLAIIVRALTDNEQRTISAIRGYFSKLQGQIAKPNSVSMLFNECGQLLINKETKSLDEWFEILIDQSIIDINEDDKIIEILVKPEDFSTVKLILEKNNADIKSAEIKLIPNDFISLDEYARERLVRFVNACENDDDISWVITNYEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK3</accession>
    <name>Q9PQK3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU288"/>
    <dbReference type="EnsemblBacteria" id="AAF30697">
        <property type="protein sequence ID" value="AAF30697"/>
        <property type="gene ID" value="UU288"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU288"/>
    <dbReference type="HOGENOM" id="CLU_3105093_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="51" mass="6116" checksum="DB7B5D0AB5BE413D" modified="2000-10-01" version="1">MTVAYHNLDINDPKNVLLATQKFFNHINEIIIDYGLDKRDQWIKKIIPFEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-01-27" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK5</accession>
    <name>SYD_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aspS</name>
        <name type="ordered locus">UU286</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688860.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQK5"/>
    <dbReference type="SMR" id="Q9PQK5"/>
    <dbReference type="STRING" id="273119.UU286"/>
    <dbReference type="EnsemblBacteria" id="AAF30695">
        <property type="protein sequence ID" value="AAF30695"/>
        <property type="gene ID" value="UU286"/>
    </dbReference>
    <dbReference type="GeneID" id="29672656"/>
    <dbReference type="KEGG" id="uur:UU286"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_14"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000110975" description="Aspartate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="1">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="526"/>
            <end position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <sequence length="578" mass="67007" checksum="DE2CC6AA21851762" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK7</accession>
    <name>PYRG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Putative CTP synthase</fullName>
            <ecNumber evidence="1">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="1">CTP synthetase</shortName>
            <shortName evidence="1">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrG</name>
        <name type="ordered locus">UU284</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks the conserved cysteine and histidine residues potentially involved in the active site of the GAT domain.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQK7"/>
    <dbReference type="SMR" id="Q9PQK7"/>
    <dbReference type="STRING" id="273119.UU284"/>
    <dbReference type="EnsemblBacteria" id="AAF30693">
        <property type="protein sequence ID" value="AAF30693"/>
        <property type="gene ID" value="UU284"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU284"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_14"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138245" description="Putative CTP synthase">
        <location>
            <begin position="1"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="310"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A7E5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="542" mass="61347" checksum="155F079EFD8C73B4" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK9</accession>
    <name>DBH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA-binding protein HU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hup</name>
        <name type="ordered locus">UU282</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688857.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQK9"/>
    <dbReference type="SMR" id="Q9PQK9"/>
    <dbReference type="STRING" id="273119.UU282"/>
    <dbReference type="EnsemblBacteria" id="AAF30691">
        <property type="protein sequence ID" value="AAF30691"/>
        <property type="gene ID" value="UU282"/>
    </dbReference>
    <dbReference type="GeneID" id="29672426"/>
    <dbReference type="KEGG" id="uur:UU282"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_2_14"/>
    <dbReference type="OMA" id="RDRVNIY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0226">DNA condensation</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000104992" description="DNA-binding protein HU">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="130" mass="14862" checksum="B4FC4BBA13CA31FB" modified="2000-10-01" version="1">MNAKIKAKTRSQMIDELSKMLNIEKKQTKAFMDTYEAFLILELSRAKEVRLGNIGKFKVSVRAERKGINPKTGETVIIPEKTIPKFTFTKGIKEIINAGISIDNERVSIDDNDFDDDDEFVEEYIVSENN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-07" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL3</accession>
    <name>SYR_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="1">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argS</name>
        <name type="ordered locus">UU278</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688892.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQL3"/>
    <dbReference type="SMR" id="Q9PQL3"/>
    <dbReference type="STRING" id="273119.UU278"/>
    <dbReference type="PRIDE" id="Q9PQL3"/>
    <dbReference type="EnsemblBacteria" id="AAF30687">
        <property type="protein sequence ID" value="AAF30687"/>
        <property type="gene ID" value="UU278"/>
    </dbReference>
    <dbReference type="GeneID" id="29672519"/>
    <dbReference type="KEGG" id="uur:UU278"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_0_1_14"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000151631" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <sequence length="550" mass="63662" checksum="0400D6105A17A69B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL6</accession>
    <name>Q9PQL6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688849.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU275"/>
    <dbReference type="EnsemblBacteria" id="AAF30684">
        <property type="protein sequence ID" value="AAF30684"/>
        <property type="gene ID" value="UU275"/>
    </dbReference>
    <dbReference type="GeneID" id="29672554"/>
    <dbReference type="KEGG" id="uur:UU275"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.285"/>
    <dbReference type="HOGENOM" id="CLU_1488407_0_0_14"/>
    <dbReference type="OMA" id="WIWATAT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="181" mass="20598" checksum="6914F7543158BFEC" modified="2000-10-01" version="1">MGLKKEKKDRSTIQLLFGTIKKRKIANYLIIAFAFLTFALAIIGSFEAIASKYAIGIGSGLSLFITIAFSVWRILMIHLEKEWNKSEIIWQSVMGAILVLSIIFWIWATTTTTIQYSSLKEHLLLLKQQDSRANFVVLTQATVDEFGVALKGGLWAWVITSCIYIFINTFNNMFMKEKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL9</accession>
    <name>Q9PQL9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable HIT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hit</name>
        <name evidence="3" type="ordered locus">UU272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688907.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU272"/>
    <dbReference type="EnsemblBacteria" id="AAF30681">
        <property type="protein sequence ID" value="AAF30681"/>
        <property type="gene ID" value="UU272"/>
    </dbReference>
    <dbReference type="GeneID" id="29672496"/>
    <dbReference type="KEGG" id="uur:UU272"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.281"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_2_14"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="152" mass="17473" checksum="94EA54D7600D4BB3" modified="2000-10-01" version="1">MQDCIFCKILKGEIISKIIDENEFAIAILDIQPASDGHMLIIPKKHYRNFSLTDPIYLDGMMRLAKNMTFVLEEVFPNVLGFNYLMNSNSSAGQVIMHTHLHIIPKQSNGRGFVFKAIKEEGDISNIDEIYKKIIIKTQKLKKSRLSKHYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM7</accession>
    <name>Q9PQM7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pacL</name>
        <name evidence="9" type="ordered locus">UU264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU264"/>
    <dbReference type="EnsemblBacteria" id="AAF30673">
        <property type="protein sequence ID" value="AAF30673"/>
        <property type="gene ID" value="UU264"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU264"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_14"/>
    <dbReference type="OMA" id="GVHRMAK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="859"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="982" mass="109956" checksum="6498BA37A7F62394" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM9</accession>
    <name>Q9PQM9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891715.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU262"/>
    <dbReference type="EnsemblBacteria" id="AAF30671">
        <property type="protein sequence ID" value="AAF30671"/>
        <property type="gene ID" value="UU262"/>
    </dbReference>
    <dbReference type="GeneID" id="29672633"/>
    <dbReference type="KEGG" id="uur:UU262"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.271"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_1_0_14"/>
    <dbReference type="OMA" id="AAHIVWA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="195" mass="22863" checksum="63FC279FFEC15B55" modified="2000-10-01" version="1">MSFKTIAYTQKNIKIIKKSKFITIVEPISDKNEVQSLFKKYKEQYYDATHICFAYVIGREFNYMKAYDDGEPNGTAGIPILNIIKIKSLTNVIIFVVRYFGGIKLGTGGLIRAYSQCAKEIIDNCEIIILQKYFYYKVVYKLKNTKFAKQILTSISYEKLIESYEDDRVILKIRINTKINIFMSKIEFIFIKHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN0</accession>
    <name>Q9PQN0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688902.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU261"/>
    <dbReference type="EnsemblBacteria" id="AAF30670">
        <property type="protein sequence ID" value="AAF30670"/>
        <property type="gene ID" value="UU261"/>
    </dbReference>
    <dbReference type="GeneID" id="29672546"/>
    <dbReference type="KEGG" id="uur:UU261"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.270"/>
    <dbReference type="HOGENOM" id="CLU_1884889_0_0_14"/>
    <dbReference type="OMA" id="HLHLTIV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="135" mass="16064" checksum="C77D5F1CE77C0767" modified="2000-10-01" version="1">MNNYIQQVIDYVNDKTYKNKTYFIKKYAFAFLTSLIIFIFLLVFGLSNYFNPLVSLVGVVLIFSVLVVFCIHIKIINNYSLNLLKWLRNQKELSYKYIINILDFILNKQLYLNLTIIEVQQICIDLEEFKKTNVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN8</accession>
    <name>IF1_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infA</name>
        <name type="ordered locus">UU253</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688844.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQN8"/>
    <dbReference type="SMR" id="Q9PQN8"/>
    <dbReference type="STRING" id="273119.UU253"/>
    <dbReference type="EnsemblBacteria" id="AAF30662">
        <property type="protein sequence ID" value="AAF30662"/>
        <property type="gene ID" value="UU253"/>
    </dbReference>
    <dbReference type="GeneID" id="29672540"/>
    <dbReference type="KEGG" id="uur:UU253"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_14"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000095900" description="Translation initiation factor IF-1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="74" mass="8384" checksum="A44BDC9C40525149" modified="2000-12-01" version="1">MADTEKLKMLGKIVEVLQGGNFRVQLENGITIMSHVSGKMRVNKINILPGDTVDVELSPYDLTRGRITYRHRDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP2</accession>
    <name>RL15_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplO</name>
        <name type="ordered locus">UU249</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688932.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQP2"/>
    <dbReference type="SMR" id="Q9PQP2"/>
    <dbReference type="STRING" id="273119.UU249"/>
    <dbReference type="EnsemblBacteria" id="AAF30658">
        <property type="protein sequence ID" value="AAF30658"/>
        <property type="gene ID" value="UU249"/>
    </dbReference>
    <dbReference type="GeneID" id="29672629"/>
    <dbReference type="KEGG" id="uur:UU249"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_14"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251582" description="50S ribosomal protein L15">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="148" mass="16317" checksum="5AE7AFB9B08D4EC1" modified="2000-10-01" version="1">MQLHNLEYKKGSRNHKEKRVGRGHGSGLGKTSGRGQDGQKARKSGMVRLAFEGGQTPLYRRVPKVGFNNDRFANKYNVVTLISLVKYETKELTVEFMYANKIAKNEDLPIKVIGNAVLPSGTVVSAHKFSKGALESISNSKAKAQILE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP6</accession>
    <name>RS8_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name evidence="1" type="synonym">rps8</name>
        <name type="ordered locus">UU245</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025683.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQP6"/>
    <dbReference type="SMR" id="Q9PQP6"/>
    <dbReference type="STRING" id="273119.UU245"/>
    <dbReference type="EnsemblBacteria" id="AAF30654">
        <property type="protein sequence ID" value="AAF30654"/>
        <property type="gene ID" value="UU245"/>
    </dbReference>
    <dbReference type="GeneID" id="45015789"/>
    <dbReference type="KEGG" id="uur:UU245"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_14"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126518" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="132" mass="14681" checksum="DD921DC9A4E809F6" modified="2000-10-01" version="1">MYLDPIAELITKINNGRKAHKAEVSFATSKLKTAILELLVKEGYIKSYDIRPTENNKSETVVKLKYKNQTTSSINGFKQISKPGLRIYSTHLNLPKVLNGLGIAIITTSKGVMSDKQARKENVGGEVIAYVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ1</accession>
    <name>RS17_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsQ</name>
        <name type="ordered locus">UU240</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025503.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ1"/>
    <dbReference type="SMR" id="Q9PQQ1"/>
    <dbReference type="STRING" id="273119.UU240"/>
    <dbReference type="EnsemblBacteria" id="AAF30649">
        <property type="protein sequence ID" value="AAF30649"/>
        <property type="gene ID" value="UU240"/>
    </dbReference>
    <dbReference type="GeneID" id="45015784"/>
    <dbReference type="KEGG" id="uur:UU240"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_14"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000233602" description="30S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <sequence length="84" mass="9751" checksum="2E57E6796C60345D" modified="2000-10-01" version="1">MERSRRKVLEGLVVSDKMQKTVVVSVETKSKHPIYRKLVISHKKYHAHNDNDDAKVGDLVEITETRPLSATKNWRVSKILERAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ3</accession>
    <name>RL16_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplP</name>
        <name evidence="1" type="synonym">rpl16</name>
        <name type="ordered locus">UU238</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688879.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ3"/>
    <dbReference type="SMR" id="Q9PQQ3"/>
    <dbReference type="STRING" id="273119.UU238"/>
    <dbReference type="EnsemblBacteria" id="AAF30647">
        <property type="protein sequence ID" value="AAF30647"/>
        <property type="gene ID" value="UU238"/>
    </dbReference>
    <dbReference type="GeneID" id="29672668"/>
    <dbReference type="KEGG" id="uur:UU238"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_14"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000062243" description="50S ribosomal protein L16">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <sequence length="138" mass="15422" checksum="6356B41A01A14EC3" modified="2000-10-01" version="1">MLQPKRTKFRKPHKVSYEGKAKGNKQVDFGEFGLMALEGAWIDARQIESARIAISKRLLKTGKMWIRIFPHMSLTKKPLEVRMGSGKGSPEKWVAVVKAGTVMFEIANVSEELMCEALRAAGNKLPIKVKIVKKGEAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ6</accession>
    <name>RS19_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsS</name>
        <name evidence="1" type="synonym">rps19</name>
        <name type="ordered locus">UU235</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025915.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ6"/>
    <dbReference type="SMR" id="Q9PQQ6"/>
    <dbReference type="STRING" id="273119.UU235"/>
    <dbReference type="EnsemblBacteria" id="AAF30644">
        <property type="protein sequence ID" value="AAF30644"/>
        <property type="gene ID" value="UU235"/>
    </dbReference>
    <dbReference type="GeneID" id="45015779"/>
    <dbReference type="KEGG" id="uur:UU235"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_14"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129935" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <sequence length="88" mass="9982" checksum="0F1B3EB4C466A1CB" modified="2000-10-01" version="1">MSRSLKKGAYADPSLLKKVEAANASVSKKPIKTWSRRSQIFPNFVGLTFEVHNGKTFLKVYVTEDMIGHKLGEFAPTRNFKNHTEAKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR4</accession>
    <name>IF3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infC</name>
        <name type="ordered locus">UU227</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQR4"/>
    <dbReference type="SMR" id="Q9PQR4"/>
    <dbReference type="STRING" id="273119.UU227"/>
    <dbReference type="PRIDE" id="Q9PQR4"/>
    <dbReference type="EnsemblBacteria" id="AAF30636">
        <property type="protein sequence ID" value="AAF30636"/>
        <property type="gene ID" value="UU227"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU227"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_14"/>
    <dbReference type="OMA" id="QPLINDQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177603" description="Translation initiation factor IF-3">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <sequence length="178" mass="20812" checksum="C5BB31A7A43C4111" modified="2000-10-01" version="1">MSSNNDARKNQPLINDQIRFRTMVVIDDHGNNLGEMNRIDALNLAASKNLDLVVIAKKGNIPVTKILDYGKYKYEQKRRQKESRKNQTIIKVKEIKIKPMIGEHDLKVRAENAKRWLEDKDNVKFVIEARGRMCTKDEFIVQAYEKFIDLIKDYGTVVQANKKVSNYRYETIIEPIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS1</accession>
    <name>FTHS_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="1">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="1">FHS</shortName>
            <shortName evidence="1">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fhs</name>
        <name type="synonym">fthS</name>
        <name type="ordered locus">UU221</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688872.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQS1"/>
    <dbReference type="SMR" id="Q9PQS1"/>
    <dbReference type="STRING" id="273119.UU221"/>
    <dbReference type="EnsemblBacteria" id="AAF30629">
        <property type="protein sequence ID" value="AAF30629"/>
        <property type="gene ID" value="UU221"/>
    </dbReference>
    <dbReference type="GeneID" id="29672511"/>
    <dbReference type="KEGG" id="uur:UU221"/>
    <dbReference type="eggNOG" id="COG2759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_3_3_14"/>
    <dbReference type="OMA" id="CGEIMTM"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000199406" description="Formate--tetrahydrofolate ligase">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <sequence length="521" mass="58466" checksum="F2C5D80295186092" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-10-31" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS5</accession>
    <name>RSGA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsgA</name>
        <name type="ordered locus">UU217</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAF30625" version="1"/>
        </conflict>
        <text>Truncated N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30625.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQS5"/>
    <dbReference type="SMR" id="Q9PQS5"/>
    <dbReference type="STRING" id="273119.UU217"/>
    <dbReference type="EnsemblBacteria" id="AAF30625">
        <property type="protein sequence ID" value="AAF30625"/>
        <property type="gene ID" value="UU217"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU217"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_2_1_14"/>
    <dbReference type="OMA" id="QANFYQV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000171538" description="Small ribosomal subunit biogenesis GTPase RsgA">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CP-type G" evidence="2">
        <location>
            <begin position="65"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="167"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="302" mass="34574" checksum="D94A05B671A2682C" modified="2003-10-31" version="2">MRAKIISVVANNFYVHLYDLKIQIKAIPKGIFKHNSHELKPMVGDDVEVELIGNTYLITKIYERYNQLIRPKVANIDIVLIVVSIVQPDLNTLSLNKYLAFYEARNIKNVLIGLSKYDLANNHLKQKINKLILDYKKNNYAVFILTKENDILLLKEKIKSKTLCLAGNSGVGKSTLINKLDPSIQQRTQEISHFLNRGKHTTTSTKLISFANGFLVDTPGFGNLEVNLTKNEMANAFNDFANYARFCKFSNCLHIEEPECAIKKAVDEKLIVNRYDDYLKIIKELPNDVLKIKTRAQNRKCK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT0</accession>
    <name>RL21_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">UU212</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688851.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQT0"/>
    <dbReference type="SMR" id="Q9PQT0"/>
    <dbReference type="STRING" id="273119.UU212"/>
    <dbReference type="EnsemblBacteria" id="AAF30620">
        <property type="protein sequence ID" value="AAF30620"/>
        <property type="gene ID" value="UU212"/>
    </dbReference>
    <dbReference type="GeneID" id="29672592"/>
    <dbReference type="KEGG" id="uur:UU212"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_1_14"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000269419" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="100" mass="11330" checksum="1D3E91F50A0B838B" modified="2000-10-01" version="1">MFAIFQTGGKQYKVQQGEKIYVEKLDLEVGSKISFDQVIMVEGSVGTPFVKNAVVNATVIKQGKQKKINIIKFKSKKHHLKRQGHRQPYTQLVIDSISVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT8</accession>
    <name>RNC_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease 3</fullName>
            <ecNumber evidence="1">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribonuclease III</fullName>
            <shortName evidence="1">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnc</name>
        <name type="ordered locus">UU205</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025836.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQT8"/>
    <dbReference type="SMR" id="Q9PQT8"/>
    <dbReference type="STRING" id="273119.UU205"/>
    <dbReference type="EnsemblBacteria" id="AAF30612">
        <property type="protein sequence ID" value="AAF30612"/>
        <property type="gene ID" value="UU205"/>
    </dbReference>
    <dbReference type="GeneID" id="45015746"/>
    <dbReference type="KEGG" id="uur:UU205"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_14"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000180451" description="Ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="166"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <sequence length="236" mass="27570" checksum="A62AB51DC9848D3F" modified="2000-10-01" version="1">MDNKKFLDFLKQNRIEPKNLSIYLEALTHKSYANEHKLTKNYQRLEFLGDACVEWVISNFIFNYKIKDNEKMRSLDEGEMTRARSNMVRSEILSYAAKDLGLTDFLMIGVGLEQDQSARMEKIYEDIFEAFIGAVAQDQGIKKVSLILEKTLIKYFREGQINYQKDYKTIFQEQAQRINKKPIMYKLVRNEGDKKEVHLVWNDLIYGIGIASTRKEAEILAAKNAILKLDDYTKKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-09-09" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU3</accession>
    <name>PSTB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate import ATP-binding protein PstB</fullName>
            <ecNumber evidence="1">7.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ABC phosphate transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-transporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pstB</name>
        <name type="ordered locus">UU200</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:24440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688921.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQU3"/>
    <dbReference type="SMR" id="Q9PQU3"/>
    <dbReference type="STRING" id="273119.UU200"/>
    <dbReference type="EnsemblBacteria" id="AAF30607">
        <property type="protein sequence ID" value="AAF30607"/>
        <property type="gene ID" value="UU200"/>
    </dbReference>
    <dbReference type="GeneID" id="29672128"/>
    <dbReference type="KEGG" id="uur:UU200"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_14"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51238">
        <property type="entry name" value="PSTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0592">Phosphate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092924" description="Phosphate import ATP-binding protein PstB">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="83"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01702"/>
        </source>
    </evidence>
    <sequence length="329" mass="37838" checksum="6CC5659C4F099FC5" modified="2000-10-01" version="1">MNDQKDNKEIQTIVPLNQKTNLNELDAKAIYDEFQKLNKYQRAFAWLKLPKQKKAELKQFLNKKKTQVDLLKEDFNHANVFEIRNFNFWYMNRTKHVLHDLNLDIKRNKVTAFIGPSGCGKSTFLRNLNQLNDLIEGTSHEGEIYFLGTNTRSKKISSLELRTRIGMVFQKPTPFEMSIFDNVAYGPRNNGINDRKILEKIVEKSLKSAALWDEVKDDLDKAGNALSGGQQQRLCIARAIALEPEVLLMDEPTSALDPIATAKIEELILELKKKYSIIIVTHSMAQAQRISDETVFFYQGWIEEAGETKTIFIHPKNKRTKDYISGKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU5</accession>
    <name>Q9PQU5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688890.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU198"/>
    <dbReference type="EnsemblBacteria" id="AAF30605">
        <property type="protein sequence ID" value="AAF30605"/>
        <property type="gene ID" value="UU198"/>
    </dbReference>
    <dbReference type="GeneID" id="29672602"/>
    <dbReference type="KEGG" id="uur:UU198"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.205"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_679389_0_0_14"/>
    <dbReference type="OMA" id="CANINLI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="390" mass="44166" checksum="C39D9AF238D8DFBF" modified="2000-10-01" version="1">MRLRYKILCASLGVVGVVGVIAAISIDYKQIPIVYANGSSSVLPLIQALSEKHHKQDIISNAGGSSLGIIEAVEQRTNIGVSSRSPNIDFEQQSVEKSHVVYDKWKQNQLKTYTIAWDGIGIIYKLNKTNHELVLTKDNIIKLFKAFTGNEQVSYYDLDPQLPKTPILAYSRTGGANASGTAEAFLTSNPLISKKEFKKKYHDIYKVIEAGTYGKLIRSTEESNTQAWTNISKDNVDGSITYLSTGFILKNYDQIIAKGYKIAYLQNKDLKNYLPFEINENKQEIVNVAKTYGWYRPFNLVFSLNMQGIKNTKEFVWWLLTNKKVEKIIQESGFIPLTFEQKNSMFLKPYKDEQSFQEAINNQSAKNNFFVSDFELIESNRINILGAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU9</accession>
    <name>Q9PQU9_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease M5</fullName>
            <ecNumber evidence="9">3.1.26.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNase M5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA terminal maturase M5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnmV</name>
        <name evidence="11" type="ordered locus">UU194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ribonuclease M5 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.8" evidence="9"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688912.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU194"/>
    <dbReference type="EnsemblBacteria" id="AAF30601">
        <property type="protein sequence ID" value="AAF30601"/>
        <property type="gene ID" value="UU194"/>
    </dbReference>
    <dbReference type="GeneID" id="29672678"/>
    <dbReference type="KEGG" id="uur:UU194"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.201"/>
    <dbReference type="eggNOG" id="COG1658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109405_1_0_14"/>
    <dbReference type="OMA" id="RLQMFQI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043822">
        <property type="term" value="F:ribonuclease M5 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01027">
        <property type="entry name" value="TOPRIM_RNase_M5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01469">
        <property type="entry name" value="RNase_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004466">
        <property type="entry name" value="RNase_M5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025156">
        <property type="entry name" value="RNase_M5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034141">
        <property type="entry name" value="TOPRIM_RNase_M5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13331">
        <property type="entry name" value="DUF4093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00334">
        <property type="entry name" value="5S_RNA_mat_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAF30601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="179" mass="20537" checksum="3A8719FBD5860A9D" modified="2000-10-01" version="1">MNKPIIKEVIIVEGKTDAQKIDQLVNAQIITTNGSEINKKTLALIKQAQLSKGIILFLDPDYQGERIRKIITNYLKDGIIKQCFISKDNMKNNSKKIGIAEANNDALLKALKSQGTFVINSIESITWLEYLSLNLNNKKIRLMLCDYLNISYCNHKQLFKRLNMMQKTFKEIKIIIEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV1</accession>
    <name>Q9PQV1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">UU192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688899.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU192"/>
    <dbReference type="EnsemblBacteria" id="AAF30599">
        <property type="protein sequence ID" value="AAF30599"/>
        <property type="gene ID" value="UU192"/>
    </dbReference>
    <dbReference type="GeneID" id="29672723"/>
    <dbReference type="KEGG" id="uur:UU192"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.199"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098250_1_0_14"/>
    <dbReference type="OMA" id="DPAKHWQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037154">
        <property type="entry name" value="YtpR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="197" mass="22532" checksum="6792373020912061" modified="2000-10-01" version="1">MYIYYNKTSLNDTLIFLKNNQQYDHQVFLNDDLLLFYHGDELIGLNLFNASEYLKNLNEGYLYPTTQLIQKLSDLIKIKLSLDNAFKGFVVGKILEVNLIPNTHLHICLVDIGDQQIQIICGAQNVRIGLKTVVATPNLLMPNGNEIKKSKLMNYDSFGMLCSQKELNINNFNSQGIVELNDEYQVGQLFTKVYSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV4</accession>
    <name>Q9PQV4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBA N-terminal paralog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688938.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU189"/>
    <dbReference type="EnsemblBacteria" id="AAF30596">
        <property type="protein sequence ID" value="AAF30596"/>
        <property type="gene ID" value="UU189"/>
    </dbReference>
    <dbReference type="GeneID" id="29672590"/>
    <dbReference type="KEGG" id="uur:UU189"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.196"/>
    <dbReference type="eggNOG" id="COG2503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1546907_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="173" mass="19672" checksum="C20DE3CE8E615EB4" modified="2000-10-01" version="1">MKLLKNKKIWVLTISSVLIGVSVITSIASCSSSNIESKLSDKLVEDEDNNYYVAYQISNYEKLKDFEKKQLEKVTFSTSITPTDKTKNSQVFNAKVNEGILFNQQAKTFYIKLVRKPEVGESIIILPNNSILKTHGFVVTNENLNFIKINKKGELQRSNTAITKKNNLTNEYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-20" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW3</accession>
    <name>RLMH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name type="ordered locus">UU180</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688906.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW3"/>
    <dbReference type="SMR" id="Q9PQW3"/>
    <dbReference type="STRING" id="273119.UU180"/>
    <dbReference type="EnsemblBacteria" id="AAF30587">
        <property type="protein sequence ID" value="AAF30587"/>
        <property type="gene ID" value="UU180"/>
    </dbReference>
    <dbReference type="GeneID" id="29672634"/>
    <dbReference type="KEGG" id="uur:UU180"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100552_0_0_14"/>
    <dbReference type="OMA" id="NEPYHHQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000198205" description="Ribosomal RNA large subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <sequence length="159" mass="18245" checksum="DF4B103A8A34D415" modified="2000-10-01" version="1">MMIKIISVGKLKQKAFVDLINDYLKRINHYLKCQEIVVSDEPEPVQISNKSLEQIKSKEASKIFKNINQNDFVIALIIESNIISSETLAKKIQQWLNTFSHDICFIIGGSNGLHESIYERANYHLSMSKMTFAHGLAKVMLCEQIYRALSILNNGKYHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW5</accession>
    <name>Y178_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative phosphotransferase enzyme IIB component UU178</fullName>
            <ecNumber>2.7.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Putative PTS system EIIB component</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">UU178</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">To M.genitalium MG129 and M.pneumoniae MPN268.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688859.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW5"/>
    <dbReference type="SMR" id="Q9PQW5"/>
    <dbReference type="STRING" id="273119.UU178"/>
    <dbReference type="EnsemblBacteria" id="AAF30585">
        <property type="protein sequence ID" value="AAF30585"/>
        <property type="gene ID" value="UU178"/>
    </dbReference>
    <dbReference type="GeneID" id="29672183"/>
    <dbReference type="KEGG" id="uur:UU178"/>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162090_0_0_14"/>
    <dbReference type="OMA" id="WLYWRIK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0598">Phosphotransferase system</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000210431" description="Putative phosphotransferase enzyme IIB component UU178">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="3">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="126" mass="14318" checksum="3DB5414136906321" modified="2000-10-01" version="1">MQNLNNKQKTLIIFLGIITFGIFIIYFFTKAKKVSQIRNTHLIVSSNIPFSLNDFYNCIGSKNNLVNVDATINTLKIELKEINALNNEKLKVLGAKGIMCNQTKISIIFGDFCLELKELIKKDLFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX2</accession>
    <name>Y171_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU171</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU171</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To U.parvum UU376.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQX2"/>
    <dbReference type="STRING" id="273119.UU171"/>
    <dbReference type="EnsemblBacteria" id="AAF30578">
        <property type="protein sequence ID" value="AAF30578"/>
        <property type="gene ID" value="UU171"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU171"/>
    <dbReference type="HOGENOM" id="CLU_069143_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220828" description="Uncharacterized protein UU171">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="199" mass="22661" checksum="694F4BE0667B1BC8" modified="2000-10-01" version="1">MIANKITINKIQNGTATIEVTFSKFKLADANKKDFVLEVKDSANDDASAISATELVFDANKKILTGKLNGLASNINYKISKFTLNNNEIKFDFKQEDQQELLNQYIQQAELNTIIDKANKKINIKLQNFSILNSFQDNQPVLTFDIEINKKDGITQVVHKSLTKNQLLNPNGLEIDLKDKMKNNIDYWTLAYVVWFLAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX9</accession>
    <name>Y165_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU165</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU165</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891696.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQX9"/>
    <dbReference type="SMR" id="Q9PQX9"/>
    <dbReference type="STRING" id="273119.UU165"/>
    <dbReference type="EnsemblBacteria" id="AAF30571">
        <property type="protein sequence ID" value="AAF30571"/>
        <property type="gene ID" value="UU165"/>
    </dbReference>
    <dbReference type="GeneID" id="45015936"/>
    <dbReference type="KEGG" id="uur:UU165"/>
    <dbReference type="HOGENOM" id="CLU_2195795_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220822" description="Uncharacterized protein UU165">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="108" mass="12964" checksum="8F479D4800B50156" modified="2000-10-01" version="1">MVDELEKNQVQPQETEENKENALYDEIDKRIQKQFENYLKTNEQLDNANKLVEAKLKEIKDLENTFKQREQELLNKIATLEQNQQFVNIHQEKPVVEDANSHFLKFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY4</accession>
    <name>Q9PQY4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025764.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU160"/>
    <dbReference type="EnsemblBacteria" id="AAF30566">
        <property type="protein sequence ID" value="AAF30566"/>
        <property type="gene ID" value="UU160"/>
    </dbReference>
    <dbReference type="GeneID" id="45015940"/>
    <dbReference type="KEGG" id="uur:UU160"/>
    <dbReference type="HOGENOM" id="CLU_1758050_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="148" mass="17947" checksum="8EE4815A3B2335FE" modified="2000-10-01" version="1">MKEYINRRILWLWILTTLWTIFLICSFFIKIGETSFVFFGKESEYTDKATLWDWMISKFPKLGSTKKWQLFLVVLFAYIICGCVDFFAISPFFWRFTTEGKNWHLKTRIEQDKLKSEWKAINEQKRSIKKAQNDLYKQNKESILNDEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY9</accession>
    <name>Y155_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU155</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU155</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026102.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQY9"/>
    <dbReference type="STRING" id="273119.UU155"/>
    <dbReference type="EnsemblBacteria" id="AAF30561">
        <property type="protein sequence ID" value="AAF30561"/>
        <property type="gene ID" value="UU155"/>
    </dbReference>
    <dbReference type="GeneID" id="29672740"/>
    <dbReference type="KEGG" id="uur:UU155"/>
    <dbReference type="HOGENOM" id="CLU_1209377_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220814" description="Uncharacterized protein UU155">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <sequence length="229" mass="27096" checksum="9C1417C7623E75D1" modified="2000-10-01" version="1">MSSNNFDNNMPRIEFKKMPLTFIRLNTKKSNNAPFVSGSFWLADKVNANVYFSEYLMERIVPFENNKTNIVILENVSCYINFNWEEKRIIMRVVSFDNIFYKHQLSEQQTIDFVSAEKEYNYQTQTVNSYSNSDDEIEIINWLESDEQKAYFDSQLMFIDYKNQGFFKNKTMPDKLKNNANALELYKQIIKLDLEAFSGLYNGLKPFEAANKLIEKGYITLNDFFKYAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ2</accession>
    <name>Y152_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU152</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ2"/>
    <dbReference type="SMR" id="Q9PQZ2"/>
    <dbReference type="STRING" id="273119.UU152"/>
    <dbReference type="EnsemblBacteria" id="AAF30558">
        <property type="protein sequence ID" value="AAF30558"/>
        <property type="gene ID" value="UU152"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU152"/>
    <dbReference type="HOGENOM" id="CLU_2621032_0_0_14"/>
    <dbReference type="OMA" id="NMTNWDK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220811" description="Uncharacterized protein UU152">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <sequence length="87" mass="10750" checksum="C1E686D083A66374" modified="2000-10-01" version="1">MKLSRRLTNMTNWDKEHALSEELRQLKDEFEDLMDDLARINKDLDFNIWERKDLEYRKASYETDIESIRLRINQKQNEMMEIIKNDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ5</accession>
    <name>Y149_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU149</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU149</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891688.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ5"/>
    <dbReference type="SMR" id="Q9PQZ5"/>
    <dbReference type="STRING" id="273119.UU149"/>
    <dbReference type="EnsemblBacteria" id="AAF30555">
        <property type="protein sequence ID" value="AAF30555"/>
        <property type="gene ID" value="UU149"/>
    </dbReference>
    <dbReference type="GeneID" id="29672161"/>
    <dbReference type="KEGG" id="uur:UU149"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.155"/>
    <dbReference type="HOGENOM" id="CLU_2332812_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220808" description="Uncharacterized protein UU149">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <sequence length="98" mass="11457" checksum="05BB55680E9A9DEA" modified="2000-10-01" version="1">MEKIVGFIVNIINVQKQMIKDLKELKNHKDIMVKDHEKLNDMLNSMIDEAVKNYKIALKNITEILNVHLNCVLYNHNLKCGVKDEKLLLPLFKRKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR07</accession>
    <name>Q9PR07_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP synthase A chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atpB</name>
        <name evidence="12" type="ordered locus">UU137</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688950.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU137"/>
    <dbReference type="EnsemblBacteria" id="AAF30543">
        <property type="protein sequence ID" value="AAF30543"/>
        <property type="gene ID" value="UU137"/>
    </dbReference>
    <dbReference type="GeneID" id="29672765"/>
    <dbReference type="KEGG" id="uur:UU137"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.143"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_3_0_14"/>
    <dbReference type="OMA" id="WNQPQLF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAF30543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="275" mass="30295" checksum="6D6B9A7387FBBCED" modified="2000-10-01" version="1">MENYSPLDIMIALPHIAAIIMVTLIIGTVSLIYFSMVKKLTVHDVPNRFVIIIGMIVDYFRGLVVDTMGAKHVKLAPYVLFTFCYIFTANLVSLFGFKEATTASAVPLAMALGTVIGGQIVALKYQKASFFLKFAFKIKGFPIMINPLEIVSKLTPIISLTFRLWGNISAAAILLNITYWAFAGFTNVVPWVGVSLIAAVVILPILIGYFTCFAGTIQAFVFTLLTSINWGLEIKEGEEHHAHLAHKKAEKLAAKKLAELDTQNQIQNNEAQVVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-25" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR21</accession>
    <name>SYC_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="ordered locus">UU123</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689137.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR21"/>
    <dbReference type="SMR" id="Q9PR21"/>
    <dbReference type="STRING" id="273119.UU123"/>
    <dbReference type="EnsemblBacteria" id="AAF30529">
        <property type="protein sequence ID" value="AAF30529"/>
        <property type="gene ID" value="UU123"/>
    </dbReference>
    <dbReference type="GeneID" id="29672271"/>
    <dbReference type="KEGG" id="uur:UU123"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_0_14"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000159516" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <sequence length="436" mass="51296" checksum="CAAA98D56BB1B8D4" modified="2000-10-01" version="1">MKLYDSYSNQLVEINDELISIYNCGPTVYNHIHIGNARPLITMDVLYRFLKKHNIKTKYVLNITDIDDKIINYALANNLKELEVSEYYFNEYLKIKKALNTLEMINPKVSTHMDKIIDYIQKLIDKQAGYFIGDDVYFDTKKALNYGQLSKRDLENDIVGMRIESAANKHNPNDFILWKKTNKGIMWNTPWGIGRPGWHSECSCLINTYIGEQVSIHGGGIDLKFPHHENENAQNQVLYNKNLAKVWMHFGLVNINNEKMSKSLNNFILVKDLLAEYDYQVVRWFFYQADYKQPIKFSHEIMKQNEKEILKIKNAIYNAKNYLYFNNQLKSLTQIDHFELFDERINDDLDFVGIVDLIHISVKKINILIKENKDMNELKLNLTQLLYMLDILGINFVDLHNDENLALLNTWKNYVDKKDYVKADELRKQLINIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR22</accession>
    <name>Q9PR22_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU122"/>
    <dbReference type="EnsemblBacteria" id="AAF30528">
        <property type="protein sequence ID" value="AAF30528"/>
        <property type="gene ID" value="UU122"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU122"/>
    <dbReference type="eggNOG" id="ENOG50343JE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228796_0_0_14"/>
    <dbReference type="OMA" id="LITPLYW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="193" mass="22706" checksum="E18908EA483DFB2D" modified="2000-10-01" version="1">MLGLGILVAYLSHFIRFNFLAFDFSLFTLVYLIYKVKYRFVYLVTILLSLANLLHGSPSWIGTMVLSLNNLFFVTMVILFKKLFIPKRPKFYLNLWVLVLSSFLTTVFNVIMNGILYTPLYWYTFKITPTLNFLEVQKIYEKHPTLFLLNIKSYWLGIIALYTSFNLIKNIIISFISLTILKIFADKKTIITY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR23</accession>
    <name>DNLJ_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="ordered locus">UU121</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689158.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR23"/>
    <dbReference type="SMR" id="Q9PR23"/>
    <dbReference type="STRING" id="273119.UU121"/>
    <dbReference type="EnsemblBacteria" id="AAF30527">
        <property type="protein sequence ID" value="AAF30527"/>
        <property type="gene ID" value="UU121"/>
    </dbReference>
    <dbReference type="GeneID" id="29672169"/>
    <dbReference type="KEGG" id="uur:UU121"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_14"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000313501" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="595"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <sequence length="673" mass="77451" checksum="C89130B8BCB2AF9F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR46</accession>
    <name>Q9PR46_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I restriction enzyme M protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hsdM-1</name>
        <name evidence="3" type="ordered locus">UU098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU098"/>
    <dbReference type="REBASE" id="4889">
        <property type="entry name" value="M.UurORF98P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30504">
        <property type="protein sequence ID" value="AAF30504"/>
        <property type="gene ID" value="UU098"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU098"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013049_0_1_14"/>
    <dbReference type="OMA" id="YEYLMGM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004546">
        <property type="entry name" value="Restrct_endonuc_T1M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00497">
        <property type="entry name" value="hsdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="348" mass="39547" checksum="8D776CB13681DB62" modified="2000-10-01" version="1">MFGDAYEYLMSMYAANAGKSGGEFFTPQEVSELLVELTLIDFNNENKDVRRKIGKVYDPCCGSGSLLLKYAKLNEGVKFYGQEINLTTYNLARINMFLHNIGYDKFDIKLGDTLLDPKHNDDKPFDAIVSNPPYSTKWEGKSNPLLANDERFHVTQLAPKGKADFAFVLHILHNLSSSGTAAIVMFPGTLYRDHAEQDIRKYLVDNVNVVDSVIQLPDNLFFGTSISTCIIVLRKNKNNNDNANGILFVDASKEFVKSGIKNKLTNANIKKIVDTIRFKKEVTYFSKLVSREEVKNKNYNLSVNTYVEKEDTSEKIDIKLLNMQIKEIVAKIEKLRKEIDEIVLELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR73</accession>
    <name>Q9PR73_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hlyC</name>
        <name evidence="11" type="ordered locus">UU072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
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            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688709.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9PR73"/>
    <dbReference type="STRING" id="273119.UU072"/>
    <dbReference type="EnsemblBacteria" id="AAF30477">
        <property type="protein sequence ID" value="AAF30477"/>
        <property type="gene ID" value="UU072"/>
    </dbReference>
    <dbReference type="GeneID" id="29672133"/>
    <dbReference type="KEGG" id="uur:UU072"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.74"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_14"/>
    <dbReference type="OMA" id="EHTMVRN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="16"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="289"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAF30477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="442" mass="50247" checksum="328E525BB1A2C4DD" modified="2000-10-01" version="1">MIEDSQETISTQANFSVGILVILAIITLILICFSVFFSAAETAITSVTTVKWKTESNKIKSKTITNVVYKMINNYTITLATILIGNTLVNTASSTIAGLFFAGIMKSFSTTSNAEAIGTGIATGIITLIVLIFGEFIPKNFAKKNPIKVLKLVAYPLNCFYILFWPLTWSLNRIFNKKSQNIITATEEELKSLIEVIRHEGTLDSQEALIINKAILFDDILIKQKMVPWTQVVKINENKTVLQSFEIFNSTGFSRLVVVNKNDEVVGIIYLKKIIKYLLNEPNKIIRTIMQTPLLINQKDTLYDGLRTMQFQRIHLGIVVDNITEKNPIGIITLENITEELTGNVYDETDNENEIKEIQIVNETTWRVDAKTNAKLFLHQYIDKDIEVNDDISMGKYISKINKNRAFKNRQLINTPNMYIETFKDVRTNQFAFLIEKKINQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR81</accession>
    <name>Y064_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU064</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU064</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688619.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR81"/>
    <dbReference type="SMR" id="Q9PR81"/>
    <dbReference type="STRING" id="273119.UU064"/>
    <dbReference type="EnsemblBacteria" id="AAF30469">
        <property type="protein sequence ID" value="AAF30469"/>
        <property type="gene ID" value="UU064"/>
    </dbReference>
    <dbReference type="GeneID" id="29672178"/>
    <dbReference type="KEGG" id="uur:UU064"/>
    <dbReference type="HOGENOM" id="CLU_190052_0_0_14"/>
    <dbReference type="OMA" id="MINEQKA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220796" description="Uncharacterized protein UU064">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="88" mass="10434" checksum="14D78CF31B5F1C4F" modified="2000-10-01" version="1">MSDEQKTKLIELKQKVNDLEFELDKIKNEFMMKIIIAVILIFFLTIVGLFYLIINLSRIISLNQKRKSLELKTKELNHEINKIEISLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR82</accession>
    <name>Y063_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU063</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU063</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688445.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR82"/>
    <dbReference type="SMR" id="Q9PR82"/>
    <dbReference type="STRING" id="273119.UU063"/>
    <dbReference type="EnsemblBacteria" id="AAF30468">
        <property type="protein sequence ID" value="AAF30468"/>
        <property type="gene ID" value="UU063"/>
    </dbReference>
    <dbReference type="GeneID" id="29672212"/>
    <dbReference type="KEGG" id="uur:UU063"/>
    <dbReference type="eggNOG" id="COG3613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1675915_0_0_14"/>
    <dbReference type="OMA" id="IFEMSTA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220795" description="Uncharacterized protein UU063">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <sequence length="158" mass="18490" checksum="C9CE296208E6F42F" modified="2000-10-01" version="1">MSKKIKIYLAGPLFTLAEINDRKQQASLIRKTFKDELPNYELDLFNPIEVNDELGANAHKPNIFFYESDIKFIDQTDIAIIDIDNTDDGTMAEMGYFVALQKHVKPTLKIYILNTDWRVHKHRNEVLNKFLDGMILSHCQYFTNFTDLLNHLLIELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR86</accession>
    <name>Q9PR86_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">msbA-1</name>
        <name evidence="11" type="ordered locus">UU059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU059"/>
    <dbReference type="EnsemblBacteria" id="AAF30464">
        <property type="protein sequence ID" value="AAF30464"/>
        <property type="gene ID" value="UU059"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU059"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_14"/>
    <dbReference type="OMA" id="HESFDGA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="342"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAF30464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="592" mass="66981" checksum="D0BAEDA46D44DCBA" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR89</accession>
    <name>SECG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">secG</name>
        <name type="ordered locus">UU056</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688648.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR89"/>
    <dbReference type="SMR" id="Q9PR89"/>
    <dbReference type="STRING" id="273119.UU056"/>
    <dbReference type="EnsemblBacteria" id="AAF30461">
        <property type="protein sequence ID" value="AAF30461"/>
        <property type="gene ID" value="UU056"/>
    </dbReference>
    <dbReference type="GeneID" id="29672287"/>
    <dbReference type="KEGG" id="uur:UU056"/>
    <dbReference type="eggNOG" id="ENOG502ZX2S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196584_0_0_14"/>
    <dbReference type="OMA" id="IVMFIMA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000157252" description="Probable protein-export membrane protein SecG">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="74" mass="8241" checksum="71410E63F403E95C" modified="2000-10-01" version="1">MALTIVLILFSVLALIIGLLLSRTSPSGGLSSLNGQDLEIFKKTKDRGWIKGLQVFMFLLTIVMILIIIFYRVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR97</accession>
    <name>Y048_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU048</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU048</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891666.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR97"/>
    <dbReference type="SMR" id="Q9PR97"/>
    <dbReference type="STRING" id="273119.UU048"/>
    <dbReference type="EnsemblBacteria" id="AAF30453">
        <property type="protein sequence ID" value="AAF30453"/>
        <property type="gene ID" value="UU048"/>
    </dbReference>
    <dbReference type="GeneID" id="29672158"/>
    <dbReference type="KEGG" id="uur:UU048"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.50"/>
    <dbReference type="eggNOG" id="ENOG5033PXC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041656_0_0_14"/>
    <dbReference type="OMA" id="NWIFIFR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220790" description="Uncharacterized protein UU048">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="496" mass="58350" checksum="4F2330427DC3525D" modified="2000-10-01" version="1">MMNTKTFTSVNRVIYDDNYSLKQQQKSSFINQFLKGLLSAITLLFFILLLIFAENTLFGLGFGDENKSMMISKSLNAFFDLHSPKYLQLNFLIVFRFFILSFTLFYTLIKNFTNLYWHRATIKKYLPWFVLYLVIATISFLLFFTFFSVWPKEVFNLVFLLLVLFLLNLSYEIFNYFISKKTNPLLYDNYKNLIIAMVFQALLLLFVIITPLVWINTGKSPNFLFVDNRFYTRIVDIFTVQSGKNFIILIAFFFFLITFIVLANTNFFALVINKRYDRNYVKNNLWFILLLFSAIFIWLLRVFAYKHENENLPVGNNHLLWVYILQSFFAIIILILYMVFTLKKRLSVKSSLNTLLNLVVTQTILSLSLFLVTLFNSKSVVSLINVFITITVQMSVFGIYIFQNKNISTKLLVLLKVIMILIILTAAIVGFDYLLTSDHHNNYLFSNIQPKMNLVQIMLLLNFSLNFTLISYLTIKFAMVIFKINKLNKELNNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA8</accession>
    <name>Q9PRA8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891660.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30442">
        <property type="protein sequence ID" value="AAF30442"/>
        <property type="gene ID" value="UU037"/>
    </dbReference>
    <dbReference type="GeneID" id="29672289"/>
    <dbReference type="KEGG" id="uur:UU037"/>
    <dbReference type="HOGENOM" id="CLU_2468151_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="88" mass="10634" checksum="0D80C3E18DA10F57" modified="2000-10-01" version="1">MKELLRLTKVKRYGKVYTPDYLVNIILDKGHYINGNINKKHVIDNSCGDGQFLTYIVDRYCKDYLINNNDLIELKKTIRNIYTWYRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB8</accession>
    <name>Q9PRB8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ABC substrate-binding protein-iron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ABCsbp-2</name>
        <name evidence="1" type="ordered locus">UU027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688581.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU027"/>
    <dbReference type="EnsemblBacteria" id="AAF30432">
        <property type="protein sequence ID" value="AAF30432"/>
        <property type="gene ID" value="UU027"/>
    </dbReference>
    <dbReference type="GeneID" id="29672281"/>
    <dbReference type="KEGG" id="uur:UU027"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.27"/>
    <dbReference type="HOGENOM" id="CLU_874196_0_0_14"/>
    <dbReference type="OMA" id="RYTKVIT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="323" mass="37130" checksum="AAC582B14CBF4151" modified="2000-10-01" version="1">MNKKIKTVFISSLIVGLLGLITTSGVACSSSIKSKQENEIYPTIKGYDQHDFSKILASEFIKIIKTNIQFLAPNKDIKYELYDARLNELDEDVIDLIIRYHFKGQTHTYKKILKGFKNAKQYRLFLENKKYLEDEKNHNTLYLMPIVNSSINISKTTVDEALKWQNSYLNINNSNNDLKYEILKITKSKTANSIDIEIKISKGNGENLASITYNKTLNGFISEADKKIYLANLEAIKQDKNQLEPQLIDEKTKQKTIKEVIENYKTLFKLPFQTGFIYEIQSVEPDVNNKTAVVFKILIKKGNGSQEAVLEYLKTIKGFNQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC3</accession>
    <name>Q9PRC3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrichrome ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fatC-1</name>
        <name evidence="8" type="ordered locus">UU022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688783.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU022"/>
    <dbReference type="EnsemblBacteria" id="AAF30427">
        <property type="protein sequence ID" value="AAF30427"/>
        <property type="gene ID" value="UU022"/>
    </dbReference>
    <dbReference type="GeneID" id="29672187"/>
    <dbReference type="KEGG" id="uur:UU022"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.22"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064507_0_0_14"/>
    <dbReference type="OMA" id="AIMGYEA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="340" mass="38343" checksum="9C40F3F6582680A4" modified="2000-10-01" version="1">MSIKIKHDQNLKHQFEQKLFFRFKKNKFFLSLSLLIITIILTLIAVAGASRFINVFSYLSDWKIITQLLFSGIALGISGYILQRLTKNRLADSSLLGMGNINLVILTILFLIFDFGQLQIQKRMEYVLPFIYLIGSTMICFFIHFLCNSSTGYIFKRIIVSGIIINLITIVIAQSLRILMSKESSMYLKTILLGNIESRSDFCFYFCFGMLTISVIWLMLNATKFKIMVTNQQISGQLGINNKSLTIQTFICISLLVSVSYSLSGNVIFVGIVAANFSFNYVKNNISNGIINAGLIGGIVLLISYIFVVLILNLSTDQTILLVPIISGPYFLYQVILLKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC7</accession>
    <name>MNME_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmE</name>
        <name evidence="1" type="synonym">thdF</name>
        <name evidence="1" type="synonym">trmE</name>
        <name type="ordered locus">UU018</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688774.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRC7"/>
    <dbReference type="SMR" id="Q9PRC7"/>
    <dbReference type="STRING" id="273119.UU018"/>
    <dbReference type="EnsemblBacteria" id="AAF30423">
        <property type="protein sequence ID" value="AAF30423"/>
        <property type="gene ID" value="UU018"/>
    </dbReference>
    <dbReference type="GeneID" id="29672324"/>
    <dbReference type="KEGG" id="uur:UU018"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_14"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
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        </ligand>
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    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <sequence length="438" mass="49464" checksum="D83E4730D8AAC0EB" modified="2000-10-01" version="1">MSTIVALATAPMNCAIHIIRVSGPKAFEIINKISTIKIKKETFKIWYTILKDDNQILDEVLINTFVAPKTFTGEDLVEINCHGGIVVANLIIKTLIKYGCQPAQRGEFSRRALLNKKMDLSKIEAINNLVNAKNELSVKGVIGALLGRVSQSIAEFRHELFMIIGQIEVNIDYPEYDDVEQVDAIILKQRLLSLDKKITKIIDQSKKFLPINKGIRVLIIGKPNVGKSTLLNALCNEQKAIVTDIPGTTRDVIESSINIDNITLNILDTAGIHLTNDFVENLGINKAKALIDKVDLILYLIPANEQQDLELYDLIKKQKHLLVYTKKDLVDQYDDKQIYINAKNNDIQSLIDEIKKLFYVQEFDNANIDVLQSQRQIGILENVHYLINNAILNLEKGDTLDLIVADLEFCNLRLNELLGISSEYDFLDDLFKNFCIGK</sequence>
</entry>
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            <dbReference type="PubMed" id="11048724"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="309" mass="32976" checksum="F2CEF524DF52FD55" modified="2000-10-01" version="1">MPSLSLINDASIYAAILILGALSGFFCERVGIANISINGQMIIGALVFTLFSTIIYKYMGTKTETEYTFIVCLIIAGILTIPTSLLFGFLTIKLKTNQIIAGTAINLLASGVATFVTYPLGDKIADKTSLSSDYLGLMKIGDGINTIYIGSILILIAVVLITIGLMIMMKKTPFGLRLYAIGENPNAADAQGINVYKYQWIAVSISGFIAGIGGGLYMYASRSPFAGEVGGIGFLALAILIAGAWRIPLIAVVSIAFAVITKTFSQIDKIPQEIGKLIPYVITLIALISFSKYSVAPKNVGIPFDKTKR</sequence>
</entry>
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    <accession>P0C7K9</accession>
    <accession>Q56557</accession>
    <accession>Q9R2X4</accession>
    <name>URE3_UREPA</name>
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        <recommendedName>
            <fullName evidence="1">Urease subunit gamma</fullName>
            <ecNumber evidence="1">3.5.1.5</ecNumber>
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        <alternativeName>
            <fullName evidence="1">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
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    <gene>
        <name evidence="1" type="primary">ureA</name>
        <name type="ordered locus">UU434</name>
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    <organism>
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        <dbReference type="NCBI Taxonomy" id="273119"/>
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            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="647" last="655">
            <title>Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli.</title>
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8550495"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="2725" last="2725">
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8626347"/>
        </citation>
        <scope>ERRATUM OF PUBMED:8550495</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="Int. J. Syst. Bacteriol." volume="49" first="1879" last="1889">
            <title>Phylogenetic analysis of Ureaplasma urealyticum -- support for the establishment of a new species, Ureaplasma parvum.</title>
            <authorList>
                <person name="kong F."/>
                <person name="James G."/>
                <person name="Ma Z."/>
                <person name="Gordon S."/>
                <person name="Bin W."/>
                <person name="Gilbert G.L."/>
            </authorList>
            <dbReference type="PubMed" id="10555372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
            <strain>ATCC 27818 / Pi / Serovar 6</strain>
            <strain>ATCC 33697 / U26 / Serovar 14</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the urease gamma subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="1"/>
    <dbReference type="EMBL" id="L40489">
        <property type="protein sequence ID" value="AAA89187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085730">
        <property type="protein sequence ID" value="AAD28134.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085731">
        <property type="protein sequence ID" value="AAD28137.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085733">
        <property type="protein sequence ID" value="AAD28143.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A82891">
        <property type="entry name" value="A82891"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891770.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0C7K9"/>
    <dbReference type="SMR" id="P0C7K9"/>
    <dbReference type="STRING" id="273119.UU434"/>
    <dbReference type="PRIDE" id="P0C7K9"/>
    <dbReference type="EnsemblBacteria" id="AAF30846">
        <property type="protein sequence ID" value="AAF30846"/>
        <property type="gene ID" value="UU434"/>
    </dbReference>
    <dbReference type="GeneID" id="29672370"/>
    <dbReference type="KEGG" id="uur:UU434"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.450"/>
    <dbReference type="eggNOG" id="COG0831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145825_1_0_14"/>
    <dbReference type="OMA" id="MQLTPHE"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000098056" description="Urease subunit gamma">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <sequence length="101" mass="11219" checksum="CEA69997E1979F16" modified="2008-05-20" version="1">MNLSLREVQKLLITVAADVARRRLARGLKLNYSEAVALITDHVMEGARDGKLVADLMQSAREVLRVDQVMEGVDTMVSIIQVEVTFPDGTKLVSVHDPIYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>P50068</accession>
    <name>EFTU_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu</fullName>
            <shortName evidence="2">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf</name>
        <name type="ordered locus">UU522</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="thesis" date="1994" institute="Heinrich-Heine University / Duesseldorf, Germany">
            <authorList>
                <person name="Bruex A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 33697 / U26 / Serovar 14</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="Z34275">
        <property type="protein sequence ID" value="CAA84029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688507.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P50068"/>
    <dbReference type="SMR" id="P50068"/>
    <dbReference type="STRING" id="273119.UU522"/>
    <dbReference type="PRIDE" id="P50068"/>
    <dbReference type="EnsemblBacteria" id="AAF30935">
        <property type="protein sequence ID" value="AAF30935"/>
        <property type="gene ID" value="UU522"/>
    </dbReference>
    <dbReference type="GeneID" id="29672348"/>
    <dbReference type="KEGG" id="uur:UU522"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_14"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091430" description="Elongation factor Tu">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <sequence length="394" mass="42902" checksum="80A887B6C59883E0" modified="1996-10-01" version="1">MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAISTVLAKKGQAIAQSYADVDKTPEERERGITINASHVEYETKTRHYAHVDCPGHADYVKNMITGAAQMDGAILVIAASDGVMAQTKEHILLARQVGVPKIVVFLNKCDFMTDPDMQDLVEMEVRELLSKYGFDGDNTPVIRGSGLKALEGDPVWEAKIDELMDAVDSWIPLPERSTDKPFLLAIEDVFTISGRGTVVTGRVERGVLKVNDEVEIVGLKDTQKTVVTGIEMFRKSLDQAEAGDNAGILLRGIKKEDVERGQVLVKPGSIKPHRTFTAKVYILKKEEGGRHTPIVSGYRPQFYFRTTDVTGAISLPAGVDLVMPGDDVEMTVELIAPVAIEDGSKFSIREGGKTVGHGSVIKTSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPN7</accession>
    <name>YIDC_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">yidC</name>
        <name type="ordered locus">UU602</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688594.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPN7"/>
    <dbReference type="STRING" id="273119.UU602"/>
    <dbReference type="EnsemblBacteria" id="AAF31016">
        <property type="protein sequence ID" value="AAF31016"/>
        <property type="gene ID" value="UU602"/>
    </dbReference>
    <dbReference type="GeneID" id="29672216"/>
    <dbReference type="KEGG" id="uur:UU602"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058030_0_0_14"/>
    <dbReference type="OMA" id="LMTITRP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000124764" description="Membrane protein insertase YidC">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="383" mass="43715" checksum="DD20085C25CDE265" modified="2000-10-01" version="1">MSSVDKQNLTNRMRISVSHFAGASNANSIKKERKKKIFNVLLKVFKIIVYAFFLGIGLYGCFQNMANHWTINSTIVGNGFELGFHVDPILGANDIRFDLIYSGTGPWYPMSDFSFDYGPFYALFVWPIAQILLHFMYATRDWPAGLNAILGLIIILLIIRVITMLISARATIQTERISEIQGKIAEINAKYKDAKDMQSRQKKQMETKELYQKHNVKPLAPFESMIITLPIFLIIYRVVTILRPLKFISIFYIWDLSATPISEIFSNFTTSGWPYIFFLLIIIPVQILSQKIPQLLARKRNRNATTVGAKNKQQLKRVRMTQNIIAIVLAVVVAISASGIGLYWFFNAIFTILQSYIIHVIIMKRRSNSATRIESKLAKLGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ8</accession>
    <name>Q9PPQ8_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nusG</name>
        <name evidence="8" type="ordered locus">UU581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688771.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU581"/>
    <dbReference type="EnsemblBacteria" id="AAF30995">
        <property type="protein sequence ID" value="AAF30995"/>
        <property type="gene ID" value="UU581"/>
    </dbReference>
    <dbReference type="GeneID" id="29672248"/>
    <dbReference type="KEGG" id="uur:UU581"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.604"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_1_14"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010216">
        <property type="entry name" value="Transcrpt_antiterm_NusG_myco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01956">
        <property type="entry name" value="NusG_myco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="6">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="258" mass="29855" checksum="93CB42148CCF7C74" modified="2000-10-01" version="1">MAYKIKDLDSKLLSDLKIDFNHRHQWYIVTVVSGNEQKVIENIKDKLNGYGYGDKLSDLKIIKEKIKEVKIYEPSEAPRSMKNRANTKWETIVVDGATKYRCTKIKEGNKFNGYIFLKAEMTDQIWFLIRNTQMVTGLVGSSGKNVKPIPVPEDKILKLIADNDAKRALISLNEKVDHEENIEVIELHEDENFTNFEVDQEVKIIADTFFGEIAKIAKIDQNKKIATVEFEFFGRINTLDLNFNDIQLYDEESDKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR9</accession>
    <name>Q9PPR9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">UU570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689021.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU570"/>
    <dbReference type="EnsemblBacteria" id="AAF30984">
        <property type="protein sequence ID" value="AAF30984"/>
        <property type="gene ID" value="UU570"/>
    </dbReference>
    <dbReference type="GeneID" id="29672749"/>
    <dbReference type="KEGG" id="uur:UU570"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.593"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_3_14"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="8">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="596" mass="66840" checksum="A3CFEDB62881E63E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS4</accession>
    <name>Q9PPS4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">UU565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689046.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU565"/>
    <dbReference type="EnsemblBacteria" id="AAF30979">
        <property type="protein sequence ID" value="AAF30979"/>
        <property type="gene ID" value="UU565"/>
    </dbReference>
    <dbReference type="GeneID" id="29672665"/>
    <dbReference type="KEGG" id="uur:UU565"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.588"/>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043038_1_0_14"/>
    <dbReference type="OMA" id="VYSHKME"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="494" mass="56007" checksum="667A7299E1328218" modified="2000-10-01" version="1">MSNNEEKTHHKNKIKKIFNWTNKTKEVLRTENNLLKQISNEATIQQSVQIEKIRYKAGLLKFAALYSTKKIFLRYLIIVIFSLLASLLVLLLVHNTGIYSAGIMGTSQGIARILQSIMISNHSSPKEAKLAYDIMFWLFAIFVNIPLLIFSYKKIGKHFTLMTLTYIITVQVFGFALSQIPNVEKIMIFGDNRLSYPPINLFFTNGILDEKIVKNIETGVLNYSNITNSKIADEFMHYVQANPNATIGDLFHLNQSLTYRQSLYEFAKPLYIFHDLIINKVQILSWVDPDQASKIPSILIYAVIYPIFDGIFLSIVYIAGGSSGGTDIISFWYSKKYGKPTGSILTYFNVATLIIGIVLGSFIPAGMINSRYWDAQYFFSPNMVASILASIVLGIVFNIYFPKHKSLKIQVYSKNVNAIIENLRANDFNNSITLNSLSDSLTLRTNYSLEIISPYIELPSLIHLVRDIDKNCLIVIYPIIDIDGEMVVKKSTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS9</accession>
    <name>Q9PPS9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppC</name>
        <name evidence="6" type="ordered locus">UU561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688752.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU561"/>
    <dbReference type="EnsemblBacteria" id="AAF30974">
        <property type="protein sequence ID" value="AAF30974"/>
        <property type="gene ID" value="UU561"/>
    </dbReference>
    <dbReference type="GeneID" id="29672630"/>
    <dbReference type="KEGG" id="uur:UU561"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.583"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_14"/>
    <dbReference type="OMA" id="PSPPTWM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="135"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="332" mass="37218" checksum="BC5384A701E28072" modified="2000-10-01" version="1">MAKFGEYLKQKSKSITSSFIDELTSDAPNKFLQPFQHQQWKIIGHLIEFRDNAYMGGRPRPFREFANRYGRSFSGLIGLAIIIILFILAIIIPFTTGSPTELRPNKRYLDYFTDGFIFGTDNNGRDLWAMLWWGLRYSLGIAIIVTAIELVVGVTLGILMGYFEMFDKIMTFIIKILTNVPTIIILMILTIILKPSFGVMIFAISFSGWIAMANQMRSQVKRARSFLWVAASKTLGTKAWKIILNFLPILIPMMITQLVFSIPGAILAESSLAFIGLSLPNTPTLGNLIADGSSIITLYPRFTLIPSFLLVCLVASIQLVGGATQDALRRQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-13" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT9</accession>
    <name>RL9_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplI</name>
        <name evidence="1" type="synonym">rpl9</name>
        <name type="ordered locus">UU551</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688495.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPT9"/>
    <dbReference type="SMR" id="Q9PPT9"/>
    <dbReference type="STRING" id="273119.UU551"/>
    <dbReference type="EnsemblBacteria" id="AAF30964">
        <property type="protein sequence ID" value="AAF30964"/>
        <property type="gene ID" value="UU551"/>
    </dbReference>
    <dbReference type="GeneID" id="29672522"/>
    <dbReference type="KEGG" id="uur:UU551"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_3_0_14"/>
    <dbReference type="OMA" id="CKDGKAN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000176700" description="50S ribosomal protein L9">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <sequence length="145" mass="16420" checksum="3E5E203806EDF15F" modified="2000-10-01" version="1">MKVILLEDIASLGKKNEIIDVSDGYAKNFLIRQKKAVALTNKSQEVLNKDLAILEAQEQQAILDATLLKDKLEQKPLQFFLKTNNLQTFGSISNKQIIDEINKEQKFITKHMITKPHALGIGEHIVEILLHKKVTAKLHVIVSKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU9</accession>
    <name>RL11_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name evidence="1" type="synonym">rpl11</name>
        <name type="ordered locus">UU541</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002162.1"/>
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    <dbReference type="AlphaFoldDB" id="Q9PPU9"/>
    <dbReference type="SMR" id="Q9PPU9"/>
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    <dbReference type="EnsemblBacteria" id="AAF30954">
        <property type="protein sequence ID" value="AAF30954"/>
        <property type="gene ID" value="UU541"/>
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    <dbReference type="GeneID" id="29672442"/>
    <dbReference type="KEGG" id="uur:UU541"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.561"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
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    <keyword id="KW-1185">Reference proteome</keyword>
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    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104406" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="150" mass="16336" checksum="1551185D33BF3722" modified="2000-10-01" version="1">MAPKKKEVTRIAKLNLIGGQAKPGPALASVGINMAEFTKSFNDKTKDQNGKVIPVIITAYKDKSFDYVIKTTPVTFLLKDIAKIKSGAKDPKKQTVATISKEQALEIARYKLIDMTAYDEEAALRMIAGSAKQMGIVIEGVSAYKEKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV3</accession>
    <name>Q9PPV3_UREPA</name>
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        <submittedName>
            <fullName evidence="6">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="KEGG" id="uur:UU537"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW9</accession>
    <name>Q9PPW9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="273119.UU520"/>
    <dbReference type="EnsemblBacteria" id="AAF30933">
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        <property type="gene ID" value="UU520"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU520"/>
    <dbReference type="eggNOG" id="COG0534">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457031_0_0_14"/>
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    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="68"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="249"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
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        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="611" mass="70568" checksum="E46CFAC22B84030F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX0</accession>
    <name>Q9PPX0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
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                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
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                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689100.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU519"/>
    <dbReference type="EnsemblBacteria" id="AAF30932">
        <property type="protein sequence ID" value="AAF30932"/>
        <property type="gene ID" value="UU519"/>
    </dbReference>
    <dbReference type="GeneID" id="29672323"/>
    <dbReference type="KEGG" id="uur:UU519"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.539"/>
    <dbReference type="eggNOG" id="COG0534">
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    </dbReference>
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    <dbReference type="OMA" id="SYITIFQ"/>
    <dbReference type="Proteomes" id="UP000000423">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="137"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="597" mass="68263" checksum="76E9575D26A32380" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-07-26" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX7</accession>
    <name>RRF_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">UU512</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688460.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPX7"/>
    <dbReference type="SMR" id="Q9PPX7"/>
    <dbReference type="STRING" id="273119.UU512"/>
    <dbReference type="EnsemblBacteria" id="AAF30925">
        <property type="protein sequence ID" value="AAF30925"/>
        <property type="gene ID" value="UU512"/>
    </dbReference>
    <dbReference type="GeneID" id="29672213"/>
    <dbReference type="KEGG" id="uur:UU512"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_14"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167573" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <sequence length="183" mass="21086" checksum="A11BE383F3602755" modified="2000-10-01" version="1">MNFKIYETKIREEFELVLKWMHNEFIKLRTGRATPAILDGILVNYYGSMMPINQLANISVPEPRVLAIKPYDRSSIKDIATAINASNLGVNPQVDVDIIRLTFAAPTEEVRKNLVKKAKQVGEEAKIRVRHIRQEAQDLFKKDSTTIEDDKKFFQTELDNLTKELNKEIETVVSHKEKDIMTV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY4</accession>
    <name>ACPH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Acyl carrier protein homolog</fullName>
            <shortName>ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU506</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text>Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of the apo-ACP-like protein.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688580.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPY4"/>
    <dbReference type="SMR" id="Q9PPY4"/>
    <dbReference type="STRING" id="273119.UU506"/>
    <dbReference type="EnsemblBacteria" id="AAF30918">
        <property type="protein sequence ID" value="AAF30918"/>
        <property type="gene ID" value="UU506"/>
    </dbReference>
    <dbReference type="GeneID" id="29672350"/>
    <dbReference type="KEGG" id="uur:UU506"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_3_14"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180268" description="Acyl carrier protein homolog">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="77" mass="8750" checksum="3CDB655FBFA968C6" modified="2000-10-01" version="1">MSINIKDLIMKIAKENKIALNMDNLNIELKSLGIDSLSAMNLIMKIEDQIGVQLPDEKLLKIKNLRDLINAFEDVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY5</accession>
    <name>Q9PPY5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU505"/>
    <dbReference type="EnsemblBacteria" id="AAF30917">
        <property type="protein sequence ID" value="AAF30917"/>
        <property type="gene ID" value="UU505"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU505"/>
    <dbReference type="HOGENOM" id="CLU_1034209_0_0_14"/>
    <dbReference type="OMA" id="IMQYIKI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035219">
        <property type="entry name" value="DUF5452"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17533">
        <property type="entry name" value="DUF5452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="286" mass="33711" checksum="D0E6CD1ADAEECC5F" modified="2000-10-01" version="1">MKILNHLKINWRSHKIKVIVGGIISLLIVITAIILGVILSTQNTNKISKKEPLTQIEDNINNKKQDAHKVNENITIIDKKGGIIHKKTDITKINQINQQKEILKDYLKNKEEKNKDQINNTNENLNKPIINVKNVDDKNKQENSTKLKNNDFISNNDKNNKINENNNISYEEKPFKLKRFNIINVIAKNKDLYQLLDFKTYFSNENINNDIKFNEKLFIKNIYEIVKSAISSFQEFCNIMQYIKIDIKYKFNKDAKNIIVIANWLFDNYNIKNETRYYEEFVLSIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPZ6</accession>
    <name>DNAG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name type="ordered locus">UU494</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891801.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPZ6"/>
    <dbReference type="SMR" id="Q9PPZ6"/>
    <dbReference type="STRING" id="273119.UU494"/>
    <dbReference type="EnsemblBacteria" id="AAF30906">
        <property type="protein sequence ID" value="AAF30906"/>
        <property type="gene ID" value="UU494"/>
    </dbReference>
    <dbReference type="GeneID" id="29672698"/>
    <dbReference type="KEGG" id="uur:UU494"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.511"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_3_14"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0639">Primosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000180532" description="DNA primase">
        <location>
            <begin position="1"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="266"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <sequence length="641" mass="75391" checksum="A6920168DB58EF47" modified="2000-12-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ01</accession>
    <name>Q9PQ01_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688609.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU489"/>
    <dbReference type="EnsemblBacteria" id="AAF30901">
        <property type="protein sequence ID" value="AAF30901"/>
        <property type="gene ID" value="UU489"/>
    </dbReference>
    <dbReference type="GeneID" id="29672377"/>
    <dbReference type="KEGG" id="uur:UU489"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.506"/>
    <dbReference type="HOGENOM" id="CLU_298952_0_0_14"/>
    <dbReference type="OMA" id="DAMAFND"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
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        <location>
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            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1003" mass="116478" checksum="5F849014DC042D94" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ07</accession>
    <name>Q9PQ07_UREPA</name>
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        <submittedName>
            <fullName evidence="3">MBA N-terminal paralog</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">UU483</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
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                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="273119.UU483"/>
    <dbReference type="EnsemblBacteria" id="AAF30895">
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        <property type="gene ID" value="UU483"/>
    </dbReference>
    <dbReference type="GeneID" id="29672228"/>
    <dbReference type="KEGG" id="uur:UU483"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.500"/>
    <dbReference type="HOGENOM" id="CLU_282836_0_0_14"/>
    <dbReference type="OMA" id="CEYLLDE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004335865" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="889"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1103" mass="129308" checksum="2048C31992C86015" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ12</accession>
    <name>Q9PQ12_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891792.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU478"/>
    <dbReference type="EnsemblBacteria" id="AAF30890">
        <property type="protein sequence ID" value="AAF30890"/>
        <property type="gene ID" value="UU478"/>
    </dbReference>
    <dbReference type="GeneID" id="29672572"/>
    <dbReference type="KEGG" id="uur:UU478"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.494"/>
    <dbReference type="eggNOG" id="ENOG50346H8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144759_0_0_14"/>
    <dbReference type="OMA" id="VNDYSKH"/>
    <dbReference type="Proteomes" id="UP000000423">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA recombination"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016881">
        <property type="entry name" value="UCP028340"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028340">
        <property type="entry name" value="UCP028340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="116" mass="13492" checksum="B42A3FB67E0E511D" modified="2000-10-01" version="1">MIKDLNSYLKDIDEMSKSSLNEDQKQLIKKILEKTDPQDLDNVFQLLIQRVKIGFSFDVAPSVHQTQIAILAKNEQLSFMNDAHNLFKNDTNSLIIGENYDVLKNLLVLERERERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ16</accession>
    <name>Q9PQ16_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30886">
        <property type="protein sequence ID" value="AAF30886"/>
        <property type="gene ID" value="UU474"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU474"/>
    <dbReference type="HOGENOM" id="CLU_005429_0_0_14"/>
    <dbReference type="OMA" id="KENGSEF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="169"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="374"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1313" mass="150069" checksum="B3625ABAA5997F91" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ18</accession>
    <name>Q9PQ18_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026601.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU472"/>
    <dbReference type="EnsemblBacteria" id="AAF30884">
        <property type="protein sequence ID" value="AAF30884"/>
        <property type="gene ID" value="UU472"/>
    </dbReference>
    <dbReference type="GeneID" id="45016065"/>
    <dbReference type="KEGG" id="uur:UU472"/>
    <dbReference type="HOGENOM" id="CLU_2605059_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="83" mass="9507" checksum="A9692D41444F15BE" modified="2000-10-01" version="1">MIYKEIVRNIIKHPLILPEGKHYHLHKILTSKDELRKGEVSLVAENGKEYTVDLSAFVDLLVDGDCIIDDNHSLVALYFDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ23</accession>
    <name>Q9PQ23_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gyrA</name>
        <name evidence="11" type="synonym">parC</name>
        <name evidence="11" type="ordered locus">UU467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891786.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9PQ23"/>
    <dbReference type="STRING" id="273119.UU467"/>
    <dbReference type="EnsemblBacteria" id="AAF30879">
        <property type="protein sequence ID" value="AAF30879"/>
        <property type="gene ID" value="UU467"/>
    </dbReference>
    <dbReference type="GeneID" id="29672277"/>
    <dbReference type="KEGG" id="uur:UU467"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.483"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_14"/>
    <dbReference type="OMA" id="RILYSMW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005741">
        <property type="entry name" value="TopoIV_A_Gpos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43493:SF9">
        <property type="entry name" value="PTHR43493:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01061">
        <property type="entry name" value="parC_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="11"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAF30879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="850" mass="97433" checksum="7027CAE200A955D3" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-09-19" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ25</accession>
    <name>DEF_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide deformylase</fullName>
            <shortName evidence="1">PDF</shortName>
            <ecNumber evidence="1">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">def</name>
        <name type="ordered locus">UU465</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891784.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ25"/>
    <dbReference type="SMR" id="Q9PQ25"/>
    <dbReference type="STRING" id="273119.UU465"/>
    <dbReference type="EnsemblBacteria" id="AAF30877">
        <property type="protein sequence ID" value="AAF30877"/>
        <property type="gene ID" value="UU465"/>
    </dbReference>
    <dbReference type="GeneID" id="29672237"/>
    <dbReference type="KEGG" id="uur:UU465"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.481"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_4_0_14"/>
    <dbReference type="OMA" id="DMMEYLV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000082872" description="Peptide deformylase">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <sequence length="198" mass="23143" checksum="19F035D052625C95" modified="2000-10-01" version="1">MYNIKFLDLLNSNLKPNPQWIFKDPHPILREVTQDIEGNELSKDDIYYLKKMVRYIDVCYHNQAKKYKIRSGIAIAANQVGWNKRATYIHFNDEAKEHHYLLINPHIIKRSSEIAYLNPGEGCLSVDDDRSGYVIRNKKVHVKAYDLISEQFIDQEFSGIIAICIQHEIGHLDAGLYYDNINQQQPFYADPSWTKIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ34</accession>
    <name>Q9PQ34_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-ribulose-5-phosphate 3 epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpe</name>
        <name evidence="1" type="ordered locus">UU456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688574.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU456"/>
    <dbReference type="EnsemblBacteria" id="AAF30868">
        <property type="protein sequence ID" value="AAF30868"/>
        <property type="gene ID" value="UU456"/>
    </dbReference>
    <dbReference type="GeneID" id="29672690"/>
    <dbReference type="KEGG" id="uur:UU456"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.472"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_2_14"/>
    <dbReference type="OMA" id="CDLILIM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="219" mass="25930" checksum="B9EC1C9BF446B78B" modified="2000-10-01" version="1">MNKQLVPSLLAFDKKYPYEQLKIFKKHHLQTIHYDVMDLTYVNNTAFETEHLEWLLKNDFLVHIHLMVINPLEKIKQYFIYKPTRISFHFEMNDYQTNLLIINEIKKHHVLAGIAIHPCLSLNDYASYLKEVDYITFMSVIPGKGGQIFLEESLLKLKKLYEYKIKNNFKFKIEIDGGITLEVIKKINIPIDFFVSGSYLVKNIEKLEQTVNEFNQLVN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ41</accession>
    <name>RUVA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">UU449</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688612.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ41"/>
    <dbReference type="SMR" id="Q9PQ41"/>
    <dbReference type="STRING" id="273119.UU449"/>
    <dbReference type="EnsemblBacteria" id="AAF30861">
        <property type="protein sequence ID" value="AAF30861"/>
        <property type="gene ID" value="UU449"/>
    </dbReference>
    <dbReference type="GeneID" id="29672569"/>
    <dbReference type="KEGG" id="uur:UU449"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087936_1_1_14"/>
    <dbReference type="OMA" id="NEYQYAT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000094705" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="195" mass="22727" checksum="70550A47F344C53B" modified="2000-10-01" version="1">MNYLIFKVIYANANIVVGEHNFIGYQIRIPKDYELEINKFCKLYLYEYISIMPNKNLIIKDLYGFRTYNERLLFIDLISINSIGPKTAINILKYDIDTIIDAIATKNIDYLITIKGINQRNANLICDQLNYKYINKVNDKNNWAKELSIGLENLGYTKKDIEYAITKVKINSQQDIDISEIISSAIKEISLRHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ50</accession>
    <name>Q9PQ50_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891773.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU440"/>
    <dbReference type="EnsemblBacteria" id="AAF30852">
        <property type="protein sequence ID" value="AAF30852"/>
        <property type="gene ID" value="UU440"/>
    </dbReference>
    <dbReference type="GeneID" id="29672451"/>
    <dbReference type="KEGG" id="uur:UU440"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.456"/>
    <dbReference type="HOGENOM" id="CLU_546217_0_0_14"/>
    <dbReference type="OMA" id="TYRININ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="499" mass="60719" checksum="A8256A5CE7649A12" modified="2000-10-01" version="1">MNKRHLVTHSLKKKLFIKTSLLSLFLIAPLIIGCTTNKSKSNNSNKLSKQIEIKENKQQEKPKTKELSPIIDIPKNDYYKVLYANNIKSFVYDGKVWDDQKQTYDLEFVNKLLAYIDQHISNLVDFELVKNNQNKPWFKWLIDYYMFLNVTYFIDNKPKFLANSIKYISLRDPEHYFDEATRIFKKYYHPNKLSSNNKDYFYSWYNFIYFAHINHYYNARELYKYYNQKFNLDLPSKYINHSYPISRIYKNDRYYFSNVNRILFKIKTYDKTRINTLFLAFKKLNQSNDENKNLIIKYLKQENLIDQNYEITNKLDFNIFLEKSFLNNKEYSSTKNELKRFFENINDQLNKFNLFVNAYWYDNKYYSISTSNTKLMNDKIRFSIINMLWRDYDITDYIKAKKDELIETNPINSHYEDRYLNLLKQLYENEWQISINKDKNNEEINQLKTKNESLKTRMQNIKNEFLQYLVKMGIIDDAKELADFSVSEFYLWSTYLSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ62</accession>
    <name>Q9PQ62_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891767.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU426"/>
    <dbReference type="EnsemblBacteria" id="AAF30838">
        <property type="protein sequence ID" value="AAF30838"/>
        <property type="gene ID" value="UU426"/>
    </dbReference>
    <dbReference type="GeneID" id="29672249"/>
    <dbReference type="KEGG" id="uur:UU426"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.442"/>
    <dbReference type="HOGENOM" id="CLU_1474579_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="183" mass="21627" checksum="074DE629C07AF351" modified="2000-10-01" version="1">MGSSLFKNNVLKDRKIAKQELQQWALKIKNKYPNANYFFKLHPIYNQNQVLDYIQEITNGIFKPIILDAKTPWENILLKDYLSIKNNKAVLFKNKNTPNFSLWGFQPTTSALLTSFDFIRNNTKLTNDEAQSIIGFDNFLLGKNYDILRRDYEPNKDYTNENLQILERIYGQLIFAKILKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ64</accession>
    <name>Q9PQ64_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU424.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU424.1"/>
    <dbReference type="EnsemblBacteria" id="AAF30836">
        <property type="protein sequence ID" value="AAF30836"/>
        <property type="gene ID" value="UU424.1"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU424.1"/>
    <dbReference type="HOGENOM" id="CLU_187777_0_0_14"/>
    <dbReference type="OMA" id="RICFYRS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="91" mass="10484" checksum="348B4CEE00F89542" modified="2000-10-01" version="1">MSFLASISPIIALNCCKYANDAFHSLMWKVGFLFFAESRICFYRSVACCSLNSNEFFVIHVLLLQAVATIVVWIIIIVNDNDENKIFYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ69</accession>
    <name>Q9PQ69_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689050.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU420"/>
    <dbReference type="EnsemblBacteria" id="AAF30831">
        <property type="protein sequence ID" value="AAF30831"/>
        <property type="gene ID" value="UU420"/>
    </dbReference>
    <dbReference type="GeneID" id="29672621"/>
    <dbReference type="KEGG" id="uur:UU420"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.436"/>
    <dbReference type="HOGENOM" id="CLU_1146797_0_0_14"/>
    <dbReference type="OMA" id="HHFNEAN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="248" mass="28908" checksum="963DDA4CE47811B5" modified="2000-10-01" version="1">MKTINLKKEFNQYCISLKTQDLIKQYFNDEKLKEKLLKNRLIGLISLIIIFIIGVGILILGAFINKGNGANLNNGAITCVIIGIFFLLCLLIPYTIVANQNKKIMHKYIEYHFNEVNVGQLIKKISTFFQEFRLLTEGFLNFKQSNQVIDINYCNEKYSLIYSFQQKPQVWLIKSTNGNKISSKEWDLKGNYDLKIYELEKWNAGFSKFYLENNIESIAFQIESKLSTIINDFEELWIKGGGFLNEEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ83</accession>
    <name>GRPE_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">UU406</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688590.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ83"/>
    <dbReference type="SMR" id="Q9PQ83"/>
    <dbReference type="STRING" id="273119.UU406"/>
    <dbReference type="EnsemblBacteria" id="AAF30817">
        <property type="protein sequence ID" value="AAF30817"/>
        <property type="gene ID" value="UU406"/>
    </dbReference>
    <dbReference type="GeneID" id="29672340"/>
    <dbReference type="KEGG" id="uur:UU406"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277163_0_0_14"/>
    <dbReference type="OMA" id="LVGFRMF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000113890" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="218" mass="25637" checksum="722DEBCC016C0A02" modified="2000-10-01" version="1">MSKNNENIKHQNNDKVNNQVDKKETKNHNKQEFKYKELYEHELKKNKELQNINTLLKDKNQQLEEQISQLNQDFIKQLETKAKQAQQILEQKVNELEARHEAKVNDAVFKIFKFKMEPLLDAINHFTKIVNQNYDDPKIQAFIEGFKMFSQNMIDGLDNLKITKISPQVNDSLNDEIMEVFEVVENTNKPSMHVVEVISDGFKYNDKVIKFAVVKVAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-02-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ85</accession>
    <name>PLSY_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">G3P acyltransferase</fullName>
            <shortName evidence="1">GPAT</shortName>
            <ecNumber evidence="1">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="1">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsY</name>
        <name type="ordered locus">UU405</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688736.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ85"/>
    <dbReference type="SMR" id="Q9PQ85"/>
    <dbReference type="STRING" id="273119.UU405"/>
    <dbReference type="EnsemblBacteria" id="AAF30815">
        <property type="protein sequence ID" value="AAF30815"/>
        <property type="gene ID" value="UU405"/>
    </dbReference>
    <dbReference type="GeneID" id="29672333"/>
    <dbReference type="KEGG" id="uur:UU405"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_3_0_14"/>
    <dbReference type="OMA" id="WRHRGNL"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000188484" description="Glycerol-3-phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <sequence length="257" mass="29114" checksum="DCE8592E638AD62D" modified="2000-10-01" version="1">MDQVYNIVMAYILTLIISPLYSYLIGSLNASIILSLVFKKQDVRLFASKNAGMTNMIRVHGKKLGILTLFLDIIKPITTVSLTYIIYKYALDAPFDLSNGFNQAILVYFGGIFTIIGHCYPIFFKFQGGKGVACYGGFLITVDPIVALIGIITLLVILLITKYMSLSAMITATFTCFLVLVPGINYIPYYNQNFTTYFFDLNYVIKGIWYVWFFLLVSASLLIYRHKTNILSIATKQERKTILFHTKSKDNLSDVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ89</accession>
    <name>Q9PQ89_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC substrate-binding protein-iron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ABCsbp-7</name>
        <name evidence="2" type="ordered locus">UU401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU401"/>
    <dbReference type="EnsemblBacteria" id="AAF30811">
        <property type="protein sequence ID" value="AAF30811"/>
        <property type="gene ID" value="UU401"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU401"/>
    <dbReference type="HOGENOM" id="CLU_566119_0_0_14"/>
    <dbReference type="OMA" id="SHINRSF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004335868" evidence="1">
        <location>
            <begin position="47"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="501" mass="56945" checksum="36DB165BB3F0F734" modified="2000-10-01" version="1">MKLFVKTKQYYFKNEDNKNMFKKNKKSLAVLLVGFSTVLISSIAVAATACARKDNNVKEEGKTTLNKLISKKAPKQNATKSSEKYILSDVNNSSTFFNSLTDPYKCFEMFAKSLDDAGYEITSHEPLKNSGKTSFLEYAKELNNKIREYVRKVANLPTIKKLRDNNTTVLWAESTQSFNSSDASKLDLYYFQQEDLFPLLYSQPDDSNVPGFGLRFPKPKNHNADKYFDNWHGIGASQNNASKNDYDWMLSMQEAFYGTADYVFFNYDSNNLEGNEDGEILKSNFEKFFKKTVNNNKIIPVDFQFEYSSIWGPIGTVRLVQSLAKRLGVSDSELASVSLDWTMPSKQTLKHIRPKNSNNDHNKFAIWFYNLWDHCVALGIQPDYASFVKEKGKTYTKLPGFLADLVDETKTEFKDFTGDAQKVAGMNLYALGGNNSHINRSFKTLIGNAIPKAVPTERGDSNNSRSPINFEFYDRTTNTLQSVEGTKVVSWTDPAKENKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ90</accession>
    <name>Q9PQ90_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrichrome ABC transporter (Permease)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fatD-2</name>
        <name evidence="8" type="ordered locus">UU400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891761.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU400"/>
    <dbReference type="EnsemblBacteria" id="AAF30810">
        <property type="protein sequence ID" value="AAF30810"/>
        <property type="gene ID" value="UU400"/>
    </dbReference>
    <dbReference type="GeneID" id="29672225"/>
    <dbReference type="KEGG" id="uur:UU400"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.415"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067576_0_0_14"/>
    <dbReference type="OMA" id="WFAGSFT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="339" mass="37614" checksum="5C4FD00DC692526E" modified="2000-10-01" version="1">MFKNKSLKFKNKLDWKTHFRRLITSLLIILSICVLICYCLFDGKELMNFKNVGEEINEGSAPYIRKFIATPIAIFLSALTLSFSGYSMQVVSRNPLASPTTLGYLPAAILGLAISKLAINQILYLPFIIGIVFASCLIVINFFLVKGNALEASFKPILVGFAIGGIITGINVLLEDLVKDINIKITGFVEPPINFQWQQLCIGGPLIIISSLANLFMAPYYTIIAKDYLLAKSLGIKVNLIFWLTAFFAVVATVSSIILIGVLTLLGMIAPHVARILNPKGNSFKQLLLSFVISLLLLTSSRWLINVYNQFDINLFSAIAALPVFAYIFVSKQYRRNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ92</accession>
    <name>Q9PQ92_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688702.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU398"/>
    <dbReference type="EnsemblBacteria" id="AAF30808">
        <property type="protein sequence ID" value="AAF30808"/>
        <property type="gene ID" value="UU398"/>
    </dbReference>
    <dbReference type="GeneID" id="29672379"/>
    <dbReference type="KEGG" id="uur:UU398"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.413"/>
    <dbReference type="HOGENOM" id="CLU_1359930_0_0_14"/>
    <dbReference type="OMA" id="SAYETKC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="201" mass="23616" checksum="B9E8530CA0383458" modified="2000-10-01" version="1">MKFKKFDSKKSILRFLQVDETKREINLSFNDTTDFIFFLKEIAEDPNIAKKNAKKLTSLYIEISNKLGNDDNTDLSVYETKCNNLIEACVIDEAIYLVNMAKNIVIFLAHNKLDLLQKDFFDKLLLIESHFNFDQNLTYSYIKNSSIALLIFHLKQFINIYDEFLNNFENVINHSLENSISTKNKLTQQINHFNTIKRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA2</accession>
    <name>Q9PQA2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891759.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU388"/>
    <dbReference type="EnsemblBacteria" id="AAF30798">
        <property type="protein sequence ID" value="AAF30798"/>
        <property type="gene ID" value="UU388"/>
    </dbReference>
    <dbReference type="GeneID" id="29672637"/>
    <dbReference type="KEGG" id="uur:UU388"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.403"/>
    <dbReference type="eggNOG" id="COG4823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_956278_0_0_14"/>
    <dbReference type="OMA" id="WIKLANF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011664">
        <property type="entry name" value="Abi_system_AbiD/AbiF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07751">
        <property type="entry name" value="Abi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="291" mass="33322" checksum="3F235A2FB7AA4582" modified="2000-10-01" version="1">MALSKHSIGLIKNLKNKGLTIKNKEKFISFLFNYGVIRVIDGYSFFLKKDNQYVKGLKSKDLINFVLLDRKIANLMGDCIMLFEQQLNAIVVQNFLKINNLNSKYVIDMRTDPFIKFESPKHYEILSENIYTYANSSNLLSQFNTNAQEIPLINLALSWTLNTTIGFYRAVDNNVQISVLEYFQLNHITPLEFIDILHIIKHFRNSISHNDMVITNSFNDNVGAFAKSLKLKSIKKVVGFLDVAAFLTAFTNDKFHVLNGNLHIKILQAIKKAKFKGVVLEHINNLLGVED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-28" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA9</accession>
    <name>UVRC_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein C</fullName>
            <shortName evidence="1">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrC</name>
        <name type="ordered locus">UU381</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891756.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQA9"/>
    <dbReference type="SMR" id="Q9PQA9"/>
    <dbReference type="STRING" id="273119.UU381"/>
    <dbReference type="EnsemblBacteria" id="AAF30791">
        <property type="protein sequence ID" value="AAF30791"/>
        <property type="gene ID" value="UU381"/>
    </dbReference>
    <dbReference type="GeneID" id="29672651"/>
    <dbReference type="KEGG" id="uur:UU381"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.396"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_14"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000138357" description="UvrABC system protein C">
        <location>
            <begin position="1"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <sequence length="584" mass="68026" checksum="2FEBF45ED778E163" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB4</accession>
    <name>DPO3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase III PolC-type</fullName>
            <shortName evidence="1">PolIII</shortName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">polC</name>
        <name type="ordered locus">UU377</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-C family. PolC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891752.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQB4"/>
    <dbReference type="SMR" id="Q9PQB4"/>
    <dbReference type="STRING" id="273119.UU377"/>
    <dbReference type="PRIDE" id="Q9PQB4"/>
    <dbReference type="EnsemblBacteria" id="AAF30786">
        <property type="protein sequence ID" value="AAF30786"/>
        <property type="gene ID" value="UU377"/>
    </dbReference>
    <dbReference type="GeneID" id="29672520"/>
    <dbReference type="KEGG" id="uur:UU377"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.391"/>
    <dbReference type="eggNOG" id="COG2176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003297_1_0_14"/>
    <dbReference type="OMA" id="YYAAYFT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00356">
        <property type="entry name" value="DNApol_PolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006308">
        <property type="entry name" value="PolC_gram_pos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044923">
        <property type="entry name" value="PolC_middle_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01405">
        <property type="entry name" value="polC_Gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000204607" description="DNA polymerase III PolC-type">
        <location>
            <begin position="1"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease">
        <location>
            <begin position="409"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00356"/>
        </source>
    </evidence>
    <sequence length="1442" mass="166229" checksum="834C3EF722ACA6D1" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB6</accession>
    <name>Q9PQB6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multiple banded antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MBA</name>
        <name evidence="3" type="ordered locus">UU375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU375"/>
    <dbReference type="EnsemblBacteria" id="AAF30784">
        <property type="protein sequence ID" value="AAF30784"/>
        <property type="gene ID" value="UU375"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU375"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.388"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054953_0_0_14"/>
    <dbReference type="OMA" id="NIEFNAA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004330940" evidence="2">
        <location>
            <begin position="28"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="415" mass="43456" checksum="909F321E43FBD714" modified="2000-10-01" version="1">MKLLKNKKFWAMTLGVTLVGAGIVAIAASCSNSTVKSKLSNQFAKSTDGKSFYAVYEIENFKDLSNDDKKSLSNIEFNAALTSAENKTESTLEKGHLVGEKIYVKLPREPKPNEQLTIISKSGLIKTSGLLISDNLNYQTEKVNFETTQPGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKEQPAGKETTGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC2</accession>
    <name>SYA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="1">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alaS</name>
        <name type="ordered locus">UU369</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689116.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQC2"/>
    <dbReference type="SMR" id="Q9PQC2"/>
    <dbReference type="STRING" id="273119.UU369"/>
    <dbReference type="EnsemblBacteria" id="AAF30778">
        <property type="protein sequence ID" value="AAF30778"/>
        <property type="gene ID" value="UU369"/>
    </dbReference>
    <dbReference type="GeneID" id="29672461"/>
    <dbReference type="KEGG" id="uur:UU369"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_14"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000075240" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <sequence length="906" mass="105191" checksum="B0A08AD8EB0A64A7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC5</accession>
    <name>Q9PQC5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU366"/>
    <dbReference type="EnsemblBacteria" id="AAF30775">
        <property type="protein sequence ID" value="AAF30775"/>
        <property type="gene ID" value="UU366"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU366"/>
    <dbReference type="HOGENOM" id="CLU_1204360_0_0_14"/>
    <dbReference type="OMA" id="CEHENYD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="211" mass="25128" checksum="6BE479B5F43CFD75" modified="2000-10-01" version="1">MEEQMSATNKKYDPQISELLELRDLANKVDNLKRKLKTIEYNHYCEHENYDSDDGETNNVYEQEVSLNHETQIVKLRVDLNDLTNLSNTKIVEVEKPVYIEKVIEVEKPIEKIVEKIVYVNQDNQVNKQESIKEEKEPKTPVKSGKYVKYRRLKNNGMSDAGWKIFELVKQTQQDKVAAEKRFDEQQEEKKRQREQKRLEKQQKLEAKNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD0</accession>
    <name>Q9PQD0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688461.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30770">
        <property type="protein sequence ID" value="AAF30770"/>
        <property type="gene ID" value="UU361"/>
    </dbReference>
    <dbReference type="GeneID" id="29672705"/>
    <dbReference type="KEGG" id="uur:UU361"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.375"/>
    <dbReference type="HOGENOM" id="CLU_1539369_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004330942" evidence="1">
        <location>
            <begin position="32"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="174" mass="20499" checksum="15CA6D00ACB4AC77" modified="2000-10-01" version="1">MKNKYFRKNKFWLLIPISFVSLGSITLVATACVKKNFYPNTFADDQIYITKNNEKTVKFRISRNDEENKKYFKDDLKWNTFINKLKKTYINVETVIPKENAKQNIKQQDLCMRALPVQVLSNNKYVDIYVKIPVLLANTKMLVVGDDLLKSFYFDTDNLIMNAKHFQPIPIKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD1</accession>
    <name>Q9PQD1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC substrate-binding protein-iron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ABCsbp-6</name>
        <name evidence="2" type="ordered locus">UU360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688796.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU360"/>
    <dbReference type="EnsemblBacteria" id="AAF30769">
        <property type="protein sequence ID" value="AAF30769"/>
        <property type="gene ID" value="UU360"/>
    </dbReference>
    <dbReference type="GeneID" id="29672347"/>
    <dbReference type="KEGG" id="uur:UU360"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.374"/>
    <dbReference type="HOGENOM" id="CLU_490837_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331265" evidence="1">
        <location>
            <begin position="27"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="544" mass="61273" checksum="837E823D02067CF4" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD2</accession>
    <name>Q9PQD2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ABC substrate-binding protein-iron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ABCsbp-5</name>
        <name evidence="1" type="ordered locus">UU359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891743.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU359"/>
    <dbReference type="EnsemblBacteria" id="AAF30768">
        <property type="protein sequence ID" value="AAF30768"/>
        <property type="gene ID" value="UU359"/>
    </dbReference>
    <dbReference type="GeneID" id="29672431"/>
    <dbReference type="KEGG" id="uur:UU359"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.373"/>
    <dbReference type="HOGENOM" id="CLU_490837_0_0_14"/>
    <dbReference type="OMA" id="RIWITSI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="544" mass="61292" checksum="CF8756202A389C00" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD5</accession>
    <name>Q9PQD5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU356"/>
    <dbReference type="EnsemblBacteria" id="AAF30765">
        <property type="protein sequence ID" value="AAF30765"/>
        <property type="gene ID" value="UU356"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU356"/>
    <dbReference type="HOGENOM" id="CLU_490837_0_0_14"/>
    <dbReference type="OMA" id="CINEPMY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="578" mass="65072" checksum="952F2478D5072790" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE8</accession>
    <name>Q9PQE8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688435.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU343"/>
    <dbReference type="EnsemblBacteria" id="AAF30752">
        <property type="protein sequence ID" value="AAF30752"/>
        <property type="gene ID" value="UU343"/>
    </dbReference>
    <dbReference type="GeneID" id="29672388"/>
    <dbReference type="KEGG" id="uur:UU343"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.357"/>
    <dbReference type="HOGENOM" id="CLU_2385281_0_0_14"/>
    <dbReference type="OMA" id="DNSKQLM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="95" mass="10984" checksum="699711638D0C395E" modified="2000-10-01" version="1">MNFDINLINENDYVFSGYIILKKHNEEIIELLTYLGDDPINDEAKIITLYNNDHIDLKNLNDGDLIIVKASLIINNKNNKQLLLKDINKLELSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF3</accession>
    <name>Q9PQF3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689120.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU338"/>
    <dbReference type="EnsemblBacteria" id="AAF30747">
        <property type="protein sequence ID" value="AAF30747"/>
        <property type="gene ID" value="UU338"/>
    </dbReference>
    <dbReference type="GeneID" id="29672357"/>
    <dbReference type="KEGG" id="uur:UU338"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.352"/>
    <dbReference type="eggNOG" id="ENOG5034B0Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435414_0_0_14"/>
    <dbReference type="OMA" id="LEFFTIK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="628" mass="74048" checksum="48D339AE117293B7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF4</accession>
    <name>Q9PQF4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylenetetrahydrofolate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folD</name>
        <name evidence="2" type="ordered locus">UU337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688679.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU337"/>
    <dbReference type="EnsemblBacteria" id="AAF30746">
        <property type="protein sequence ID" value="AAF30746"/>
        <property type="gene ID" value="UU337"/>
    </dbReference>
    <dbReference type="GeneID" id="29672403"/>
    <dbReference type="KEGG" id="uur:UU337"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.351"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_14"/>
    <dbReference type="OMA" id="ATPQSCI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="1">
        <location>
            <begin position="126"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="269" mass="31609" checksum="C321DB3D5CAD6AE6" modified="2000-10-01" version="1">MKLKIDFLYEKVLTELLTKKNKTKKRIYVFYDSDLVNFNSAYIQSKLKYAKLFSVKLIIYDLNAYQIQENHHFLSKLKQANKDFLFFEFPLSKKHLDQNYFQYLTFQNDLDGINSHLFLNKKQENQIIYHPATINAILTLIKELDVNLNDYRICIIGRSPYLGDYLYKLLNPKNNKINIIHSQTKNPLRIIKESNFIISCVNKAHIFNSNALSDNSYLIDVTTEYINNKLCGSFLINKNDALNRNIKYTPVPGGIGKLTTLFLFLNYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG5</accession>
    <name>Q9PQG5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688471.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU326"/>
    <dbReference type="EnsemblBacteria" id="AAF30735">
        <property type="protein sequence ID" value="AAF30735"/>
        <property type="gene ID" value="UU326"/>
    </dbReference>
    <dbReference type="GeneID" id="29672444"/>
    <dbReference type="KEGG" id="uur:UU326"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.339"/>
    <dbReference type="HOGENOM" id="CLU_2060445_0_0_14"/>
    <dbReference type="OMA" id="SSMMNEF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="119" mass="13814" checksum="04EA6043ED2C5646" modified="2000-10-01" version="1">MEKTIIQLEFNEEELASIKKIKDKMDPNNNLELNVFLKDLIKDLARDYLNFSNQSFESIAKQMNDLKDLIGNVANDPSSFDFNSVMNEFQKFSKSQKDEEKEIKNDTEIKTATKPTKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG6</accession>
    <name>Q9PQG6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">UU325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688515.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU325"/>
    <dbReference type="EnsemblBacteria" id="AAF30734">
        <property type="protein sequence ID" value="AAF30734"/>
        <property type="gene ID" value="UU325"/>
    </dbReference>
    <dbReference type="GeneID" id="29672481"/>
    <dbReference type="KEGG" id="uur:UU325"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.338"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_3_0_14"/>
    <dbReference type="OMA" id="YNNAVQA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="219" mass="25645" checksum="32082EA3A7ED16A7" modified="2000-10-01" version="1">MDLWKEQDENGISPNVSNERKVVVASNGEKTLYIFIIVISIISIIGWIFLLVWWFNTKNHLIQTKNSVNEASSSIQVAQTKRFDLLNKMIEQTKSYYKYEEKVLDEITKNRSIQMSNDINKNEEVLNKLQNLVNVQFERYPDLKSSNILMELMSTSSYLENEIASSRRAYNSRATDWNIMIFQFMTVIVAEKLKLETFPIYAANKQERKDVDMKSLSDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG7</accession>
    <name>LEPA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4</fullName>
            <shortName evidence="1">EF-4</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA</name>
        <name type="ordered locus">UU324</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688644.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQG7"/>
    <dbReference type="SMR" id="Q9PQG7"/>
    <dbReference type="STRING" id="273119.UU324"/>
    <dbReference type="EnsemblBacteria" id="AAF30733">
        <property type="protein sequence ID" value="AAF30733"/>
        <property type="gene ID" value="UU324"/>
    </dbReference>
    <dbReference type="GeneID" id="29672470"/>
    <dbReference type="KEGG" id="uur:UU324"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_14"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176369" description="Elongation factor 4">
        <location>
            <begin position="1"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="599" mass="67044" checksum="5F02CB98F42C2138" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-05" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH1</accession>
    <name>IF2_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB</name>
        <name type="ordered locus">UU320</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688753.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQH1"/>
    <dbReference type="SMR" id="Q9PQH1"/>
    <dbReference type="STRING" id="273119.UU320"/>
    <dbReference type="EnsemblBacteria" id="AAF30729">
        <property type="protein sequence ID" value="AAF30729"/>
        <property type="gene ID" value="UU320"/>
    </dbReference>
    <dbReference type="GeneID" id="29672437"/>
    <dbReference type="KEGG" id="uur:UU320"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_14"/>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137278" description="Translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="115"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="124"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="124"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="170"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <sequence length="614" mass="68049" checksum="A41FF74375609876" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH3</accession>
    <name>Q9PQH3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">nusA</name>
        <name evidence="10" type="ordered locus">UU318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891732.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU318"/>
    <dbReference type="EnsemblBacteria" id="AAF30727">
        <property type="protein sequence ID" value="AAF30727"/>
        <property type="gene ID" value="UU318"/>
    </dbReference>
    <dbReference type="GeneID" id="29672401"/>
    <dbReference type="KEGG" id="uur:UU318"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.331"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_14"/>
    <dbReference type="OMA" id="RIPGERC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NusA_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="KH_5" evidence="9">
        <location>
            <begin position="253"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAF30727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="458" mass="52638" checksum="5A546F73B2E0481E" modified="2000-10-01" version="1">MSNSFKSKEFIEYFKDTAKQNEIEFEVLSSIIKEAFEKAYLRTHPGENFETNIDLKQGTINCFRNLVVVENEKVHNEDLETCLDDAVEILLDDARKINANAQIGDLIKQHISIDNFKSIEVGQIGSLLRQKITEIHNKRVADFWKPSLMKMIRAKVAEVNYNKQRNEITGVKVELDDQWKTLGYLSRKDRIGDEKFKVGETYDFLIKEVKEQSRLWPILLSRTEPELVEEILKREVVDIKNGNIEIKKIARIAGFKTKVAVSTNLLNIEPVAVVVGNKGLTITSISKQLNNERIDIIRYADDKRIFIANAIGLDKLKGLLVQENESGQRSAIAIVSKDDLPSVIGRGGANIRLIAKITEWNIDVKTIEQAFEENILYEKFDEKIYRSWNIESINKKNVTNDEMLALIDSIEDDKIEQDVQLNHPLKQQEKKVVSSNDEDGENDETQLEYLEGFEDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH9</accession>
    <name>Q9PQH9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689124.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU312"/>
    <dbReference type="EnsemblBacteria" id="AAF30721">
        <property type="protein sequence ID" value="AAF30721"/>
        <property type="gene ID" value="UU312"/>
    </dbReference>
    <dbReference type="GeneID" id="29672498"/>
    <dbReference type="KEGG" id="uur:UU312"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.325"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_2_14"/>
    <dbReference type="OMA" id="GEKYFEY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="191" mass="21945" checksum="3932274AA0A4E8D6" modified="2000-10-01" version="1">MNSTYQLFIDVTSRKCILAIYKNFKIHTSIIVDTNNNLTDIIVEHLNNLLKITNLQYQDLEAIYLNTGPGSFTGIRVGAIVAKTICTIFNKIKLFINDSLNIIANGKNDVFVYLDAKGNKSYVITITNNIQNEYKIITNKELQNELKNTSLTIIDANQIDYHDLIYNLKFDNFKLTNILDFRLNYVKKPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI0</accession>
    <name>Q9PQI0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase complex, probable ribosomal protein-alanine-acetyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ard1</name>
        <name evidence="2" type="ordered locus">UU311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688620.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU311"/>
    <dbReference type="EnsemblBacteria" id="AAF30720">
        <property type="protein sequence ID" value="AAF30720"/>
        <property type="gene ID" value="UU311"/>
    </dbReference>
    <dbReference type="GeneID" id="29672507"/>
    <dbReference type="KEGG" id="uur:UU311"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.324"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_14"/>
    <dbReference type="OMA" id="YMNFYEM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="146" mass="17451" checksum="397483CBA070ED13" modified="2000-10-01" version="1">MLKNLLIRPADQKDLNDIAIFENRFFLNDCYSMRNLEEIFHNSNYQIIIVEYEQKNIAYLIYMKSVDFNEILKIGVDENYRNLKIGSLLIDLLKQKKQNILLEVSDLNTNALNFYLKHGFIKQNIRKRYYANGSDAILMIWKYNQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ1</accession>
    <name>Q9PQJ1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription termination factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nusB</name>
        <name evidence="3" type="ordered locus">UU300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688871.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU300"/>
    <dbReference type="EnsemblBacteria" id="AAF30709">
        <property type="protein sequence ID" value="AAF30709"/>
        <property type="gene ID" value="UU300"/>
    </dbReference>
    <dbReference type="GeneID" id="29672391"/>
    <dbReference type="KEGG" id="uur:UU300"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.312"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_2_14"/>
    <dbReference type="OMA" id="YCDENEY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NusB" evidence="2">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="127" mass="15120" checksum="0B071B9EF06F40DA" modified="2000-10-01" version="1">MKTQWAKRVKLFQFIYHWLITKKNKPIALKCALVDFDLDLNWINVGEYILDNYEQLTKMIKPLISKDWTFERLSYVEQALLLSAYGEYLVLKTPKKIIIDQTLITTHNYSNNESYKFINAILDQLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK1</accession>
    <name>Q9PQK1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688876.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU290"/>
    <dbReference type="EnsemblBacteria" id="AAF30699">
        <property type="protein sequence ID" value="AAF30699"/>
        <property type="gene ID" value="UU290"/>
    </dbReference>
    <dbReference type="GeneID" id="29672505"/>
    <dbReference type="KEGG" id="uur:UU290"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.300"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_0_0_14"/>
    <dbReference type="OMA" id="TISAPWH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="196" mass="22811" checksum="1472ED1A208C6633" modified="2000-10-01" version="1">MAVEKIKISKVKLKIVSALFNLLKTNSFNKIKISQIIEVADVSRPSYYRNFSDKISIINYFIKNIYNWKVVSKLINNNLNINFDEVGFTKFYEISLQISLEFKEYFLILDKNNFSGLIVDLTTESGFYAIGNMSNNSIDKYLINYLTGFFCNIRMQWLKNGAKESIHDMAVFLTNVLKDNVIKKLEKYQSCNNIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK8</accession>
    <name>Q9PQK8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PpGpp 3'-pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">relA</name>
        <name evidence="3" type="synonym">spoT</name>
        <name evidence="3" type="ordered locus">UU283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688867.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU283"/>
    <dbReference type="EnsemblBacteria" id="AAF30692">
        <property type="protein sequence ID" value="AAF30692"/>
        <property type="gene ID" value="UU283"/>
    </dbReference>
    <dbReference type="GeneID" id="29672513"/>
    <dbReference type="KEGG" id="uur:UU283"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.293"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_0_0_14"/>
    <dbReference type="OMA" id="YEAINFK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="51"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="718" mass="83818" checksum="F13A17C2007EB1A6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL4</accession>
    <name>RS21_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpsU</name>
        <name type="synonym">rps21</name>
        <name type="ordered locus">UU277</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688933.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQL4"/>
    <dbReference type="SMR" id="Q9PQL4"/>
    <dbReference type="STRING" id="273119.UU277"/>
    <dbReference type="EnsemblBacteria" id="AAF30686">
        <property type="protein sequence ID" value="AAF30686"/>
        <property type="gene ID" value="UU277"/>
    </dbReference>
    <dbReference type="GeneID" id="29672551"/>
    <dbReference type="KEGG" id="uur:UU277"/>
    <dbReference type="HOGENOM" id="CLU_207223_1_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178398" description="30S ribosomal protein S21">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="55" mass="6661" checksum="E6F079AF83A63FF7" modified="2000-10-01" version="1">MSRGVSVEGDLEKALKKFKRISNETKKDSKRHEYYLSPRIRRKEKIKEANKYRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM3</accession>
    <name>Q9PQM3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoU-2</name>
        <name evidence="4" type="ordered locus">UU268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688833.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU268"/>
    <dbReference type="EnsemblBacteria" id="AAF30677">
        <property type="protein sequence ID" value="AAF30677"/>
        <property type="gene ID" value="UU268"/>
    </dbReference>
    <dbReference type="GeneID" id="29672523"/>
    <dbReference type="KEGG" id="uur:UU268"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.277"/>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110125_1_0_14"/>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="172" mass="20376" checksum="3CE095F1DB3E4FFB" modified="2000-10-01" version="1">MLNIVLFEPEIILNTGNIARMCVGFDANLHLVRPYGFILDKKRFHKDFIRASTNHLNALKLYEYDDFNEFINKNNISGDEIYFFTRYGTKTPCDYQYQNIIQHNVYLVFGKESTGIDHNILKKYPHNWIRIPTSINLRSLNIANSVAMGIYEVVRQNNFKDLFKYEPHKKFE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM4</accession>
    <name>SYV_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Valyl-tRNA synthetase</fullName>
            <shortName evidence="1">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">valS</name>
        <name type="ordered locus">UU267</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688900.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQM4"/>
    <dbReference type="SMR" id="Q9PQM4"/>
    <dbReference type="STRING" id="273119.UU267"/>
    <dbReference type="EnsemblBacteria" id="AAF30676">
        <property type="protein sequence ID" value="AAF30676"/>
        <property type="gene ID" value="UU267"/>
    </dbReference>
    <dbReference type="GeneID" id="29672606"/>
    <dbReference type="KEGG" id="uur:UU267"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_14"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000106242" description="Valine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="805"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="523"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <sequence length="874" mass="103390" checksum="3124ECE18B6F7E93" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM6</accession>
    <name>Y265_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0154 protein UU265</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU265</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0154 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891717.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQM6"/>
    <dbReference type="SMR" id="Q9PQM6"/>
    <dbReference type="STRING" id="273119.UU265"/>
    <dbReference type="EnsemblBacteria" id="AAF30674">
        <property type="protein sequence ID" value="AAF30674"/>
        <property type="gene ID" value="UU265"/>
    </dbReference>
    <dbReference type="GeneID" id="29672526"/>
    <dbReference type="KEGG" id="uur:UU265"/>
    <dbReference type="eggNOG" id="COG3763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2182819_0_0_14"/>
    <dbReference type="OMA" id="FVSMKIM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00363">
        <property type="entry name" value="UPF0154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005359">
        <property type="entry name" value="UPF0154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03672">
        <property type="entry name" value="UPF0154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000214992" description="UPF0154 protein UU265">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="109" mass="12223" checksum="00EE24A524356823" modified="2000-10-01" version="1">MNFSSFIFKVSDVFKSVIHEASDVVTKADLDNANAHTHSLAVGLGIGIVLFLIAGLIIGYFISMKIMKRQLKKNPPISKDTIRMIYQQVGRKPSESQINEIYNRAVKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM8</accession>
    <name>Q9PQM8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688877.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30672">
        <property type="protein sequence ID" value="AAF30672"/>
        <property type="gene ID" value="UU263"/>
    </dbReference>
    <dbReference type="GeneID" id="29672524"/>
    <dbReference type="KEGG" id="uur:UU263"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.272"/>
    <dbReference type="eggNOG" id="ENOG502ZHFE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_460734_0_0_14"/>
    <dbReference type="OMA" id="GTWRENI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="594" mass="71190" checksum="7CE6981467FD307D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN3</accession>
    <name>RL17_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">UU258</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026179.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQN3"/>
    <dbReference type="SMR" id="Q9PQN3"/>
    <dbReference type="STRING" id="273119.UU258"/>
    <dbReference type="EnsemblBacteria" id="AAF30667">
        <property type="protein sequence ID" value="AAF30667"/>
        <property type="gene ID" value="UU258"/>
    </dbReference>
    <dbReference type="GeneID" id="45015802"/>
    <dbReference type="KEGG" id="uur:UU258"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_2_2_14"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000267963" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <sequence length="119" mass="13192" checksum="9594F2534F597375" modified="2000-10-01" version="1">MSYINKPGKTRAWRKMVSRQQVSDVISHGSIVTTKTKAKESQRHVDHLITLAKKNTLASRRAAAAILLGTNQHSADDLLRKLFNELGPKYANRAGGYTRVIKLGNRPGDNTEEAVLQLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-27" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN6</accession>
    <name>RS13_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name evidence="1" type="synonym">rps13</name>
        <name type="ordered locus">UU255</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688863.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQN6"/>
    <dbReference type="SMR" id="Q9PQN6"/>
    <dbReference type="STRING" id="273119.UU255"/>
    <dbReference type="EnsemblBacteria" id="AAF30664">
        <property type="protein sequence ID" value="AAF30664"/>
        <property type="gene ID" value="UU255"/>
    </dbReference>
    <dbReference type="GeneID" id="29672542"/>
    <dbReference type="KEGG" id="uur:UU255"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_14"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132165" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="132" mass="15048" checksum="FD726B5F0693A890" modified="2000-10-01" version="1">MARILGVDIPNDKRVVISLTYIFGIGKSTSQQILKLANIDENIRVKDLADEQIAEIRRVALNFVKANGEKLQLEGDLRRTVAMDIKRLMEIGSYRGIRHRRGLPVRGQRTKTNARTRKGPRKTVANKKIETR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN7</accession>
    <name>RL36_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmJ</name>
        <name type="synonym">rpl36</name>
        <name type="ordered locus">UU254</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688931.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQN7"/>
    <dbReference type="SMR" id="Q9PQN7"/>
    <dbReference type="STRING" id="273119.UU254"/>
    <dbReference type="EnsemblBacteria" id="AAF30663">
        <property type="protein sequence ID" value="AAF30663"/>
        <property type="gene ID" value="UU254"/>
    </dbReference>
    <dbReference type="GeneID" id="29672460"/>
    <dbReference type="KEGG" id="uur:UU254"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000126291" description="50S ribosomal protein L36">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <sequence length="37" mass="4126" checksum="FEBB681CC0CC523F" modified="2000-10-01" version="1">MKVRASVKAICKDCKIVKRSGVVRVICANSKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN9</accession>
    <name>Q9PQN9_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ordered locus">UU252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688884.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU252"/>
    <dbReference type="EnsemblBacteria" id="AAF30661">
        <property type="protein sequence ID" value="AAF30661"/>
        <property type="gene ID" value="UU252"/>
    </dbReference>
    <dbReference type="GeneID" id="29672611"/>
    <dbReference type="KEGG" id="uur:UU252"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.261"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_14"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="249" mass="27927" checksum="A0B00001BB70019B" modified="2000-10-01" version="1">MVIVKTEKDIAAIKEAVRIWKIAREAIYKQAKAGVSLKELDLLAKEVIEANGGIAAFHNYLGFKGHICISVNECVIHGVPTDYVLKDGDKVTFDVGVKYDNHYCDAAFTIIINNSNVEALKISEICKKSIDEAVAIIKPKVTTHAISNAIQKFIEKNGYFVLRDFAGHGCGNEIHEDPLIPNYRSLLYRNVTLEENMVICIEPMILSGSNAYYIDPNDQWSVKSKNHQMTCHWEHMILITKDGCEVLTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP4</accession>
    <name>RL18_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name evidence="1" type="synonym">rpl18</name>
        <name type="ordered locus">UU247</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688827.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQP4"/>
    <dbReference type="SMR" id="Q9PQP4"/>
    <dbReference type="STRING" id="273119.UU247"/>
    <dbReference type="EnsemblBacteria" id="AAF30656">
        <property type="protein sequence ID" value="AAF30656"/>
        <property type="gene ID" value="UU247"/>
    </dbReference>
    <dbReference type="GeneID" id="29672667"/>
    <dbReference type="KEGG" id="uur:UU247"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_14"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131379" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <sequence length="121" mass="13477" checksum="1A0D0FAE841B790A" modified="2000-10-01" version="1">MKRINFSRAKQRALRAKRLHVKIRNLQLAANKPVLVITKTNAHIWAQLICYNKNITLASSSSVQLDLQNGNKDNARLVGVDIAKKALAQGFKQVIFNKNGAKYHGRIKALADAAREAGLEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP8</accession>
    <name>RL5_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name evidence="1" type="synonym">rpl5</name>
        <name type="ordered locus">UU243</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688965.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQP8"/>
    <dbReference type="SMR" id="Q9PQP8"/>
    <dbReference type="STRING" id="273119.UU243"/>
    <dbReference type="EnsemblBacteria" id="AAF30652">
        <property type="protein sequence ID" value="AAF30652"/>
        <property type="gene ID" value="UU243"/>
    </dbReference>
    <dbReference type="GeneID" id="29672530"/>
    <dbReference type="KEGG" id="uur:UU243"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_14"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125021" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="184" mass="20339" checksum="7342F9CB806F66D9" modified="2000-10-01" version="1">MAFLKDLYKNKVAKDLQKEFAYSSVMQIPKIEKVVINAGIGNAVADKKHLEAAISELTLITGQRPVETKAKKSIATFKLRAGQSIGAKVTLRGDRMWAFIETLFNIALPRVRDFKGISNNSFDNQGNYTLGIKEQIIFPQVVYDDVKSVRGFDVTFVTTAKTAQEAKALLVGLGAPFQKVRGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR7</accession>
    <name>Q9PQR7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689232.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU225"/>
    <dbReference type="EnsemblBacteria" id="AAF30633">
        <property type="protein sequence ID" value="AAF30633"/>
        <property type="gene ID" value="UU225"/>
    </dbReference>
    <dbReference type="GeneID" id="29672631"/>
    <dbReference type="KEGG" id="uur:UU225"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.233"/>
    <dbReference type="HOGENOM" id="CLU_2235420_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004335874" evidence="2">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="105" mass="11782" checksum="3D63E1364FA9ADE4" modified="2000-10-01" version="1">MKKWQKILTIALPTSLLVAIPIVVASCSTKSEAQKEFEKTYKEYLSWLDKLASKMPALKEAFSTLKEEINKQINKSEKLSDEAYKALTASLKVSIDGMKKTLGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS3</accession>
    <name>Q9PQS3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amt-2</name>
        <name evidence="10" type="ordered locus">UU219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU219"/>
    <dbReference type="EnsemblBacteria" id="AAF30627">
        <property type="protein sequence ID" value="AAF30627"/>
        <property type="gene ID" value="UU219"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU219"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_14"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="46"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAF30627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="521" mass="56473" checksum="7C14CBFA36E29759" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS9</accession>
    <name>KGUA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Guanylate kinase</fullName>
            <ecNumber>2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">gmk</name>
        <name type="ordered locus">UU213</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688865.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQS9"/>
    <dbReference type="SMR" id="Q9PQS9"/>
    <dbReference type="STRING" id="273119.UU213"/>
    <dbReference type="EnsemblBacteria" id="AAF30621">
        <property type="protein sequence ID" value="AAF30621"/>
        <property type="gene ID" value="UU213"/>
    </dbReference>
    <dbReference type="GeneID" id="29672624"/>
    <dbReference type="KEGG" id="uur:UU213"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_14"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000170635" description="Guanylate kinase">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="191" mass="22005" checksum="8E552F2E9AF19E9F" modified="2000-10-01" version="1">MKRGKLIVFSGPSGVGKHTILSKIINRKDLNLAYSISMTTRKKREGEVNGVDYYFVNDEEFKKAILNNELIEWAEFVGNKYGTPRTIVEKLRDEGKNVILEIEVVGALKVLDLYKNDDLISIFLLPPSIDELKKRLLKRNTETLETIKKRIQKATHEITIKDYYQYNIINDNPDHAANQLAEIILNEIKQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-25" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV0</accession>
    <name>KPRS_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="1">RPPK</shortName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="1">P-Rib-PP synthase</shortName>
            <shortName evidence="1">PRPP synthase</shortName>
            <shortName evidence="1">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prs</name>
        <name type="synonym">prsA</name>
        <name type="ordered locus">UU193</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891707.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQV0"/>
    <dbReference type="SMR" id="Q9PQV0"/>
    <dbReference type="STRING" id="273119.UU193"/>
    <dbReference type="EnsemblBacteria" id="AAF30600">
        <property type="protein sequence ID" value="AAF30600"/>
        <property type="gene ID" value="UU193"/>
    </dbReference>
    <dbReference type="GeneID" id="29672284"/>
    <dbReference type="KEGG" id="uur:UU193"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.200"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_0_14"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000141221" description="Ribose-phosphate pyrophosphokinase">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <sequence length="330" mass="36371" checksum="7A9CFD76890D8FCF" modified="2000-10-01" version="1">MSKNDDILLFSLSNSHQLANKIANLLKIELSPIRIDKFADGELIVAPQVPVRGRRVIIIQSTSKPVNDSLMELLIAIDSIKRASAKAISVVIPYYGYARQDRKAKPREPITARLVAKMIESAGATSVLTWDIHSLQTQGFFDIPFDSLEAVWVLMKHYFSAYKDSSNITIVSPDYGGVKRAREISIATGATLAIVDKRRSGKNQVEINNVLGDVKDRDCVIVDDMIDTGGTILGAAKIVREKGAKSITIIATHGLFNNNARQHFQQAIKDRIINKICIADTIENEPFDGLEIVSIAPAIAKCIEIYSEGTGSMSFVHDENSKVLFAKKIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV6</accession>
    <name>RPOB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="1">RNAP subunit beta</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoB</name>
        <name type="ordered locus">UU187</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891703.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQV6"/>
    <dbReference type="SMR" id="Q9PQV6"/>
    <dbReference type="STRING" id="273119.UU187"/>
    <dbReference type="EnsemblBacteria" id="AAF30594">
        <property type="protein sequence ID" value="AAF30594"/>
        <property type="gene ID" value="UU187"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU187"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.194"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_1_14"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000047991" description="DNA-directed RNA polymerase subunit beta">
        <location>
            <begin position="1"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <sequence length="1434" mass="162023" checksum="2841BFA50C19BA7A" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV7</accession>
    <name>Q9PQV7_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pyk</name>
        <name evidence="13" type="ordered locus">UU186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689159.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU186"/>
    <dbReference type="EnsemblBacteria" id="AAF30593">
        <property type="protein sequence ID" value="AAF30593"/>
        <property type="gene ID" value="UU186"/>
    </dbReference>
    <dbReference type="GeneID" id="29672687"/>
    <dbReference type="KEGG" id="uur:UU186"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.193"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_1_0_14"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="3"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAF30593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="474" mass="54553" checksum="345ED8644AD277F0" modified="2000-10-01" version="1">MFSKTRIIATVGPATTKLFSNWLEFNDLNNINDAQQVCINIKDLILSGVNIFRMNLSHGDQKIHLFRTQLIKKIADELKIKVEILFDTKGPEIRVCEMSDNNFIIKNSEVIIHCKEKVLGSFNEFSVTDATGQYNMISDVKINHRILIDDGKLILIVKKIDFLKNIIYTTAKNSYSLKTNKRLNLPDANYSLPFLSKKDIDDINLAVKLKIPYLALSFISNIKQINEVKQLLKKSSFIPKLIAKIETQEAIDNLEEIIKNTDGIMVARGDLGLEVPFYKIPIYQNKIVELCHKYNKYCIIATQMLDSLERNIIPTRAEVTDVYYAVKQKVNATMLSGETAAGIDPINAVQVMKSIILETENNNIENEITFKKNELLIPKEVKLKILSFHKLKINKHKLLVVNLISKNSKHLVYDILKYDFNFNILFVIDKNQEHDLLLKNANFIISENKMLKQEELLKSFNIDFNNHEFLFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX1</accession>
    <name>Q9PQX1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBA N-terminal paralog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688908.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30579">
        <property type="protein sequence ID" value="AAF30579"/>
        <property type="gene ID" value="UU172"/>
    </dbReference>
    <dbReference type="GeneID" id="29672721"/>
    <dbReference type="KEGG" id="uur:UU172"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.179"/>
    <dbReference type="eggNOG" id="COG2503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546216_0_0_14"/>
    <dbReference type="OMA" id="GNNTQNE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005706133" evidence="1">
        <location>
            <begin position="28"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="499" mass="57978" checksum="0BC564668CE61A1B" modified="2000-10-01" version="1">MKLLKNKKFWAMSLSAIAISTSIVAFAASCSNTNIKSKLSKQLAQTKDQKNHFAVYEIENYTKLTDEEKKSLENLEFGVSILDKDGKNPINIKVKGVQKEGKIYVKLPRKPEVNEKLLVVPTKNILKTEALVLNNDNLNYQTVTFEQVPDQKLEPKEEKQTKAVDYEKAIKDEDYVKQITLSNLEKYISNEYQYLNPNNKTLDYKNHSFVQKFLDEIDLLAQKLESNDLNLEDKQIYEKIILGLRWLLAEDNNETKNKALELFKDYFTTIMKATKVNDKVHYDPSFINEFYGSISNLFEEHDLEPSVEIESNKIRIVKEDKDVIKDKTVTATFNLYNGFDWSTLLKDVVFKEYKKDSNGKPVIDEKTKMPIETDKIVEDPVVMRLEIAEYPKDWNTSKENPKNFSYINFKKSEVLKSPKLVFTKVFNLDKEQKYHINNVMFSHKLIPNLLKALDIKNNTTNAELIKKIKENMTAIDEKTQTNLNTNYIPLSLTETNNKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX8</accession>
    <name>Y16A_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU165.2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU165.2</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026528.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQX8"/>
    <dbReference type="STRING" id="273119.UU165.2"/>
    <dbReference type="EnsemblBacteria" id="AAF30572">
        <property type="protein sequence ID" value="AAF30572"/>
        <property type="gene ID" value="UU165.2"/>
    </dbReference>
    <dbReference type="GeneID" id="29672694"/>
    <dbReference type="KEGG" id="uur:UU165.2"/>
    <dbReference type="HOGENOM" id="CLU_2025743_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220823" description="Uncharacterized protein UU165.2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="122" mass="14067" checksum="E88CCA36A2A4B275" modified="2000-10-01" version="1">MNKIIKFHNERIKWLWILTAILAISFFVICFNNVKWIYTENTAKYELLTSSLEKIVKFYSFSLVDKPFARGVPNSIDVFSRAIIGVAFGLGFVGTMLIDYFIISKVAYIVKQKIKQSKKVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ9</accession>
    <name>Q9PQZ9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase-recombinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ripX</name>
        <name evidence="4" type="ordered locus">UU145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU145"/>
    <dbReference type="EnsemblBacteria" id="AAF30551">
        <property type="protein sequence ID" value="AAF30551"/>
        <property type="gene ID" value="UU145"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU145"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093495_0_0_14"/>
    <dbReference type="OMA" id="IRAMEIY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="260" mass="31400" checksum="35E3935FBA24AA0E" modified="2000-10-01" version="1">MERQSMINKFLQSIKKRNLSKNTYLTYESHLRKFKVQEQSFKQIIKQLLNNNYKPKSLKLAKSILSEYWKFSKQYQYVQELEQIKLSKEQKSYKKVFSLDDIKKCLKINKQDTKQIKFYKTILLFYATTGIRAMEIYQLKQINNDLFVISGKGNKNRQICYIEHLWNNIKNKKLPSTKTLRKYLKVFFDNKNVSLHTLRRSFITNFLTSNENYKRGDMLKIVQDLVGHENIQTTLQYVQITKEQVDDVYKEFFKEFENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR01</accession>
    <name>Q9PR01_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30549">
        <property type="protein sequence ID" value="AAF30549"/>
        <property type="gene ID" value="UU143"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU143"/>
    <dbReference type="eggNOG" id="ENOG5033VE3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263815_0_0_14"/>
    <dbReference type="OMA" id="DRENRAN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331266" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="3">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1272" mass="149379" checksum="B110E502B96770F9" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR18</accession>
    <name>Q9PR18_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891682.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU126"/>
    <dbReference type="EnsemblBacteria" id="AAF30532">
        <property type="protein sequence ID" value="AAF30532"/>
        <property type="gene ID" value="UU126"/>
    </dbReference>
    <dbReference type="GeneID" id="29672174"/>
    <dbReference type="KEGG" id="uur:UU126"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.132"/>
    <dbReference type="eggNOG" id="ENOG5033VE3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285590_0_0_14"/>
    <dbReference type="OMA" id="QANNDYR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1084" mass="127253" checksum="4198EAC38106B60F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR25</accession>
    <name>SECA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">UU119</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689106.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR25"/>
    <dbReference type="SMR" id="Q9PR25"/>
    <dbReference type="STRING" id="273119.UU119"/>
    <dbReference type="EnsemblBacteria" id="AAF30525">
        <property type="protein sequence ID" value="AAF30525"/>
        <property type="gene ID" value="UU119"/>
    </dbReference>
    <dbReference type="GeneID" id="29672143"/>
    <dbReference type="KEGG" id="uur:UU119"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_14"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000073495" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <sequence length="837" mass="96317" checksum="A5319B46438F6787" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR32</accession>
    <name>Y112_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU112</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU112</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689147.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR32"/>
    <dbReference type="SMR" id="Q9PR32"/>
    <dbReference type="STRING" id="273119.UU112"/>
    <dbReference type="EnsemblBacteria" id="AAF30518">
        <property type="protein sequence ID" value="AAF30518"/>
        <property type="gene ID" value="UU112"/>
    </dbReference>
    <dbReference type="GeneID" id="29672147"/>
    <dbReference type="KEGG" id="uur:UU112"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735563_0_0_14"/>
    <dbReference type="OMA" id="LANTFFE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220800" description="Uncharacterized protein UU112">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <sequence length="375" mass="45109" checksum="FD2A82436D41FC2D" modified="2000-10-01" version="1">MKICDNISEINDDQDLVFIDIEATDSKGEQRIIQFSGYRLNIKKNKIFNFNKKFNPEQEINSRIKTLLNFNKNFNNIEQMPKLDKQAAREIYCFVKNAIVITFTDFDIKKMHELFTYYNFDFEKIVYFDVYKFFEKKLQTKSVPSLFSLGILSGIKINFFKLHNALYDAFILKEIFMCIRHKTNEELYEMYRYYEFLPKIISSSYFVTNEQEKNRGIIKKEIKYVMYIKEFDFSNKFNLDFVVYKKDHHFYSKPIYDSSLELQTISSLTSKSNFMKVKLANIFFNYLSKSAVFSIKKLSIKQSEKFLKFYKTQTNKRKVIKVLNLNLKKEIKPENFVIKAQIICEILFKNPIIHHFVHEYLKIFQNIFSQEEKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR34</accession>
    <name>Q9PR34_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891678.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU110"/>
    <dbReference type="EnsemblBacteria" id="AAF30516">
        <property type="protein sequence ID" value="AAF30516"/>
        <property type="gene ID" value="UU110"/>
    </dbReference>
    <dbReference type="GeneID" id="29672146"/>
    <dbReference type="KEGG" id="uur:UU110"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.116"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405401_0_0_14"/>
    <dbReference type="OMA" id="HEIVGIN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000044">
        <property type="entry name" value="Uncharacterised_lipoprot_MG045"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00905">
        <property type="entry name" value="MG045FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="678" mass="78048" checksum="BCD2E02F3629ECC6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR49</accession>
    <name>Q9PR49_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hsdR</name>
        <name evidence="12" type="ordered locus">UU095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689104.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU095"/>
    <dbReference type="REBASE" id="4886">
        <property type="entry name" value="UurORF98P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30501">
        <property type="protein sequence ID" value="AAF30501"/>
        <property type="gene ID" value="UU095"/>
    </dbReference>
    <dbReference type="GeneID" id="29672200"/>
    <dbReference type="KEGG" id="uur:UU095"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.101"/>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004848_1_1_14"/>
    <dbReference type="OMA" id="FTMNWAK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022625">
        <property type="entry name" value="TypeI_RM_Rsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12008">
        <property type="entry name" value="EcoR124_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="308"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAF30501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1045" mass="122106" checksum="D5CF93618DD0B746" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR52</accession>
    <name>Q9PR52_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689010.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU092"/>
    <dbReference type="EnsemblBacteria" id="AAF30498">
        <property type="protein sequence ID" value="AAF30498"/>
        <property type="gene ID" value="UU092"/>
    </dbReference>
    <dbReference type="GeneID" id="29672757"/>
    <dbReference type="KEGG" id="uur:UU092"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.96"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029433_1_0_14"/>
    <dbReference type="OMA" id="QKITIMI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="595" mass="69787" checksum="80FAEDDA40950108" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR53</accession>
    <name>Q9PR53_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ffh</name>
        <name evidence="9" type="ordered locus">UU091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689022.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU091"/>
    <dbReference type="EnsemblBacteria" id="AAF30497">
        <property type="protein sequence ID" value="AAF30497"/>
        <property type="gene ID" value="UU091"/>
    </dbReference>
    <dbReference type="GeneID" id="29672244"/>
    <dbReference type="KEGG" id="uur:UU091"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.95"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_14"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="448" mass="50013" checksum="3A685ED441F2AB63" modified="2000-10-01" version="1">MFKAMIGSIVSKQMSKKLKNATIVEEDIKELLSEIRIALLDADVNLLVVKKFIKNIKEKTIGLYVEANQKPADLVLKIIKDELVEILGKENKPVNTAKSQLKIMMVGLQGSGKTTTTGKLANYFKNKYNKKPLLVAADIYRPAAIDQLRTLAKQVRVDFWEEGTQRPDLIVKNALNKADENENNLIIVDTAGRLQTNEELMQELVNVKKTLNPDEVFLVVDAMAGQDIINVATEFNNWLKLTGIIVTKLDSDARAGAVLSLTSLLNIPIKFTGTGEKIGSIDSFYPERMADRILGLGDIMTLAEKAADVIDEKQVRGSMQRMMAGKMDLEDLMRQMSQISKLGSFSGIAKMIPGLNNISENQIGDAESKMKIWTILLSSMTLKERRDPRVFKKEPSRRIRVLKGSGRSPDELNKLLKQWEVSRDKMAELGKMLQKGKNPFSKSGGLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR54</accession>
    <name>Q9PR54_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU090"/>
    <dbReference type="EnsemblBacteria" id="AAF30496">
        <property type="protein sequence ID" value="AAF30496"/>
        <property type="gene ID" value="UU090"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU090"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034828_2_0_14"/>
    <dbReference type="OMA" id="IQREFVW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="34"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="584" mass="67696" checksum="DCB1229496598F1B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR77</accession>
    <name>Q9PR77_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688618.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9PR77"/>
    <dbReference type="STRING" id="273119.UU068"/>
    <dbReference type="EnsemblBacteria" id="AAF30473">
        <property type="protein sequence ID" value="AAF30473"/>
        <property type="gene ID" value="UU068"/>
    </dbReference>
    <dbReference type="GeneID" id="29672191"/>
    <dbReference type="KEGG" id="uur:UU068"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.70"/>
    <dbReference type="eggNOG" id="ENOG503466U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110277_0_0_14"/>
    <dbReference type="OMA" id="YHELTHI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="218" mass="25727" checksum="4688C713F60D0015" modified="2000-10-01" version="1">MNFKSTIVNKKPIDWKHTIVLEELNVDPKALEMHKERINTVFAKQTEEQRSQQLHNIIVRENLFNKAMTYLADFYEIDVNEEDIKDLAPRIKQAFGVEDEKLAYEIAQKIIAKALIFQDLQKEFTIEIKDEELTKILESYYEETNLSIRDFKENKAQWEAAKSTLLEEKTTAFIVDKFDRDLSILEANIRKKIAEQMELDKKIKEIQDNNKSKQNADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR79</accession>
    <name>Q9PR79_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pta</name>
        <name evidence="3" type="ordered locus">UU066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688802.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU066"/>
    <dbReference type="EnsemblBacteria" id="AAF30471">
        <property type="protein sequence ID" value="AAF30471"/>
        <property type="gene ID" value="UU066"/>
    </dbReference>
    <dbReference type="GeneID" id="29672266"/>
    <dbReference type="KEGG" id="uur:UU066"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.68"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949783_0_0_14"/>
    <dbReference type="OMA" id="NECENIW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="199"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="293" mass="33370" checksum="7D517206800FB4E2" modified="2000-10-01" version="1">MLSSINKLKNKLKNLAKKPIKVLFIEQSLEIDKAKKMLSQDTLINIVDLSSFKTPEIINECEEIWYELRKLKGESRNDAQIAVNDNLNFAVCLSYLKKIDVLIVGANLSSKTCFSSILKILKNPNGSIAYSTMVMINKRELIFMSDCALNLNLNKQQMIDAAKYSCTISRNYFDVLNNHVGYISYLSQNDVIYQNKNFDFIGPIQFDAVVDLKVRNKKVPNIHQYHINHYVFDNISIANTVFKIYQTKLNYLTVGTYISNILTKVSVISRSASSDEIIATTYLLCVAFLTDLT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR88</accession>
    <name>RNR_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease R</fullName>
            <shortName evidence="1">RNase R</shortName>
            <ecNumber evidence="1">3.1.13.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>VacB protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnr</name>
        <name type="synonym">vacB</name>
        <name type="ordered locus">UU057</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688547.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR88"/>
    <dbReference type="SMR" id="Q9PR88"/>
    <dbReference type="STRING" id="273119.UU057"/>
    <dbReference type="EnsemblBacteria" id="AAF30462">
        <property type="protein sequence ID" value="AAF30462"/>
        <property type="gene ID" value="UU057"/>
    </dbReference>
    <dbReference type="GeneID" id="29672268"/>
    <dbReference type="KEGG" id="uur:UU057"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_7_3_14"/>
    <dbReference type="OMA" id="DWYEYRS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000166414" description="Ribonuclease R">
        <location>
            <begin position="1"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="639"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <sequence length="721" mass="83174" checksum="67EEFA9A4E4FD4AA" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR94</accession>
    <name>Y051_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU051</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU051</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR94"/>
    <dbReference type="STRING" id="273119.UU051"/>
    <dbReference type="EnsemblBacteria" id="AAF30456">
        <property type="protein sequence ID" value="AAF30456"/>
        <property type="gene ID" value="UU051"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU051"/>
    <dbReference type="eggNOG" id="ENOG5034AM4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130375_0_0_14"/>
    <dbReference type="OMA" id="NEENTWQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220793" description="Uncharacterized protein UU051">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <sequence length="170" mass="20287" checksum="B01153D6A9A40F13" modified="2000-10-01" version="1">MKMIMITMVVFMNHNYNIQITLLENKKFNIDNGLLYVNVNEENTWQKIENNTVLAYEIILLKIVDDDYKKTFYLFLKNTHISVLNNIVKIQALNDLHFFIKDGLNKKNNHKKELVDKYKNITNNILELEAKQQLGLTLSEFLDLDNLKQEQYITNMQIRLNLVEYKKDEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR96</accession>
    <name>Y049_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU049</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU049</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688416.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR96"/>
    <dbReference type="STRING" id="273119.UU049"/>
    <dbReference type="EnsemblBacteria" id="AAF30454">
        <property type="protein sequence ID" value="AAF30454"/>
        <property type="gene ID" value="UU049"/>
    </dbReference>
    <dbReference type="GeneID" id="29672180"/>
    <dbReference type="KEGG" id="uur:UU049"/>
    <dbReference type="eggNOG" id="ENOG5033YTF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119972_0_0_14"/>
    <dbReference type="OMA" id="MINEAVN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021222">
        <property type="entry name" value="DUF2714"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10896">
        <property type="entry name" value="DUF2714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220791" description="Uncharacterized protein UU049">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <sequence length="171" mass="19846" checksum="280D175895EE4F89" modified="2000-10-01" version="1">MKKNKSNLTPTTNYFDVFNTYKEKKASVDLITYEELMASVLFDNKLGFESEVYLDFVKKFTLAFEKKLDIWFENFIINFNLNLKFSTTIMIPILVTKANSTTDAINFRNDQNPVYNNFLISYNQKIKKLLLQNHPVQILPHLILFKSNLNGSLVLVFSEKIIASIEQKSGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR99</accession>
    <name>Y046_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU046</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU046</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">To U.parvum UU044.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688654.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR99"/>
    <dbReference type="SMR" id="Q9PR99"/>
    <dbReference type="STRING" id="273119.UU046"/>
    <dbReference type="EnsemblBacteria" id="AAF30451">
        <property type="protein sequence ID" value="AAF30451"/>
        <property type="gene ID" value="UU046"/>
    </dbReference>
    <dbReference type="GeneID" id="29672316"/>
    <dbReference type="KEGG" id="uur:UU046"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020577_0_0_14"/>
    <dbReference type="OMA" id="KFFEYNE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030942">
        <property type="entry name" value="Mycoplas_M_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030941">
        <property type="entry name" value="Predic_Ig_block"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04524">
        <property type="entry name" value="mycoplas_M_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04526">
        <property type="entry name" value="predic_Ig_block"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220789" description="Uncharacterized protein UU046">
        <location>
            <begin position="1"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="791" mass="89388" checksum="38F23BE72BEEAA1C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA2</accession>
    <name>Q9PRA2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891665.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU043"/>
    <dbReference type="EnsemblBacteria" id="AAF30448">
        <property type="protein sequence ID" value="AAF30448"/>
        <property type="gene ID" value="UU043"/>
    </dbReference>
    <dbReference type="GeneID" id="29672185"/>
    <dbReference type="KEGG" id="uur:UU043"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.45"/>
    <dbReference type="eggNOG" id="ENOG5033SXH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015669_0_0_14"/>
    <dbReference type="OMA" id="LWINSEY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007326">
        <property type="entry name" value="Lipoprotein-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022382">
        <property type="entry name" value="Mycoplasma_peptidase_DUF31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022381">
        <property type="entry name" value="Uncharacterised_MG067"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01732">
        <property type="entry name" value="DUF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04200">
        <property type="entry name" value="Lipoprotein_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00840">
        <property type="entry name" value="Y06768FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331272" evidence="1">
        <location>
            <begin position="24"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoprotein-associated type-17" evidence="3">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF31" evidence="2">
        <location>
            <begin position="379"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="838" mass="95584" checksum="A9DDABE0699F525F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA6</accession>
    <name>MNMG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmG</name>
        <name evidence="1" type="synonym">gidA</name>
        <name type="ordered locus">UU039</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891662.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRA6"/>
    <dbReference type="SMR" id="Q9PRA6"/>
    <dbReference type="STRING" id="273119.UU039"/>
    <dbReference type="EnsemblBacteria" id="AAF30444">
        <property type="protein sequence ID" value="AAF30444"/>
        <property type="gene ID" value="UU039"/>
    </dbReference>
    <dbReference type="GeneID" id="29672170"/>
    <dbReference type="KEGG" id="uur:UU039"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.41"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_14"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000117207" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG">
        <location>
            <begin position="1"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <sequence length="614" mass="69193" checksum="5DFC22A8B3B70ACF" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-08" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB9</accession>
    <name>RS2_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsB</name>
        <name evidence="1" type="synonym">rps2</name>
        <name type="ordered locus">UU026</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891651.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRB9"/>
    <dbReference type="SMR" id="Q9PRB9"/>
    <dbReference type="STRING" id="273119.UU026"/>
    <dbReference type="EnsemblBacteria" id="AAF30431">
        <property type="protein sequence ID" value="AAF30431"/>
        <property type="gene ID" value="UU026"/>
    </dbReference>
    <dbReference type="GeneID" id="29672142"/>
    <dbReference type="KEGG" id="uur:UU026"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.26"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_0_0_14"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000134270" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="349" mass="39123" checksum="C53AEBF70E269DE3" modified="2000-10-01" version="1">MSQMENSTKKVESVANVEVVTTENAKVEQKPTSPADAIQLKVNANSTIKNLKTLVSIVKLTESGAHIGLNPKKWNPKMASYIHAKRSNNHVIDILKTILFLDRAYKFLQEVSQNGGTVMFVGTRGRVVKELIKAEAERTNSFYVTQRWLGGTLTNFTNISRSLKKFNSNLALLESEEINKYSKKEQIAINKETAKLEKFYGGIKNMKQRPDVLILVDPVNDVNAIKEARKLNIPVIALANTNADPQLIDYIIPVNNYSVKSITLILGVLADSIAELHGEPTKIVGRPDSEIVLPETKSNWKQNNYDPSKRGYNPKYVNHKSTFNKFNNKKPVDSTTNEIKTNVIKAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC0</accession>
    <name>Q9PRC0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrichrome ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fecC</name>
        <name evidence="8" type="ordered locus">UU025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688689.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU025"/>
    <dbReference type="EnsemblBacteria" id="AAF30430">
        <property type="protein sequence ID" value="AAF30430"/>
        <property type="gene ID" value="UU025"/>
    </dbReference>
    <dbReference type="GeneID" id="29672275"/>
    <dbReference type="KEGG" id="uur:UU025"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.25"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754280_0_0_14"/>
    <dbReference type="OMA" id="AMVYWSF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="367" mass="40996" checksum="BC47B4DD7795A3E3" modified="2000-10-01" version="1">MQNYTFRFKLFKQIKNQQVKKLKPLILIGATVFLIIAIFSIWVWNISYANFYDQQLNKYVYFPLHESLKLIFNGHFLDPTNIKYLNLQATFWASISSILSGISLAIAGCVTQALTKNPLADSSTLGIVQSSVFMIVIAFSYNMISFGELFGFAIIGGIIASIILLILVFATRSRLSYIKITLAGLAIGVFFNTISYFIRIQSAKGSSINFKYVLGGSENIYTTHIDPFLTLWVSAILILIGVILACFLAYKLTLLEIGDEKAKNLGSSIIIIKILAIISTIFLVSPTILLVGNIAFVGLFGPHIVRKIFSIRDYRYVMPLSGLLGAMITSLGLILYRETIYINSSIWMSFIGAPVLAYLGWKHWNRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC8</accession>
    <name>Y017_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uncharacterized metal-dependent hydrolase UU017</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU017</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688502.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRC8"/>
    <dbReference type="SMR" id="Q9PRC8"/>
    <dbReference type="STRING" id="273119.UU017"/>
    <dbReference type="EnsemblBacteria" id="AAF30422">
        <property type="protein sequence ID" value="AAF30422"/>
        <property type="gene ID" value="UU017"/>
    </dbReference>
    <dbReference type="GeneID" id="29672310"/>
    <dbReference type="KEGG" id="uur:UU017"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_14"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202009" description="Uncharacterized metal-dependent hydrolase UU017">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AFQ7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="265" mass="30929" checksum="2D338DFF40AA9E74" modified="2000-10-01" version="1">MLEKIKIIDTHTHPNIEPLIEEFDDIIFKCYEQGIGLNIVGVDLKTSQTAIQQAKKFKFLTCSVAIHPNDLHNIENDFVALEKLIAENIDYISCIGECGLDYYHEQNYDHDFQKHWFKKHIELAKKYHKPLMLHIRNAHDDAIAILKELAVQDVIIHCFTDKKEYAQQYIEMGYYISYPGVITFKPTKNNQLHELYEAIKITPLDKILVETDAPYLTPVPKRGQTNYPYYVLYTSAFIANLLGITHEKMQKILLENSLRILNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD1</accession>
    <name>Q9PRD1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribose/galactose ABC transporter (N-term domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rbsC-1</name>
        <name evidence="8" type="ordered locus">UU014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688451.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU014"/>
    <dbReference type="EnsemblBacteria" id="AAF30419">
        <property type="protein sequence ID" value="AAF30419"/>
        <property type="gene ID" value="UU014"/>
    </dbReference>
    <dbReference type="GeneID" id="29672270"/>
    <dbReference type="KEGG" id="uur:UU014"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.14"/>
    <dbReference type="eggNOG" id="COG1340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362859_0_0_14"/>
    <dbReference type="OMA" id="WNGRKNI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="736" mass="84637" checksum="33872F58F29B6EB3" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRE1</accession>
    <name>RL31_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE</name>
        <name evidence="1" type="synonym">rpl31</name>
        <name type="ordered locus">UU002</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688758.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRE1"/>
    <dbReference type="STRING" id="273119.UU002"/>
    <dbReference type="EnsemblBacteria" id="AAF30409">
        <property type="protein sequence ID" value="AAF30409"/>
        <property type="gene ID" value="UU002"/>
    </dbReference>
    <dbReference type="GeneID" id="29672162"/>
    <dbReference type="KEGG" id="uur:UU002"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_4_2_14"/>
    <dbReference type="OMA" id="SCGKKYE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000173175" description="50S ribosomal protein L31">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="95" mass="10737" checksum="5701575274519B67" modified="2000-10-01" version="1">MRDIHPVSKPCVYNCVTCKKEFIIDSAAKNTEVAIEVCSNCHTFFIGKQNATTTLRGRAEKLNNRFEAGLNNINKKPEKKKIQGKSEPRKSLNEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRE2</accession>
    <name>DNAA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dnaA</name>
        <name type="ordered locus">UU001</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688755.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRE2"/>
    <dbReference type="SMR" id="Q9PRE2"/>
    <dbReference type="STRING" id="273119.UU001"/>
    <dbReference type="EnsemblBacteria" id="AAF30408">
        <property type="protein sequence ID" value="AAF30408"/>
        <property type="gene ID" value="UU001"/>
    </dbReference>
    <dbReference type="GeneID" id="29672652"/>
    <dbReference type="KEGG" id="uur:UU001"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_2_14"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114294" description="Chromosomal replication initiator protein DnaA">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="457" mass="52655" checksum="3F5AE8C5927F0BE2" modified="2000-10-01" version="1">MANNYQTLYDSAIKRIPYDLISDQAYAILQNAKTHKVCDGVLYIIVANAFEKSIINGNFINIISKYLSEEFKKENIVNFEFIIDNEKLLINSNFLIKETNIKNRFNFSDELLRYNFNNLVISNFNQKAIKAIENLFSNNYDNSSMCNPLFLFGKVGVGKTHIVAAAGNRFANSNPNLKIYYYEGQDFFRKFCSASLKGTSYVEEFKKEIASADLLIFEDIQNIQSRDSTAELFFNIFNDIKLNGGKIILTSDRTPNELNGFHNRIISRLASGLQCKISQPDKNEAIKIINNWFEFKKKYQITDEAKEYIAEGFHTDIRQMIGNLKQICFWADNDTNKDLIITKDYVIECSVENEIPLNIVVKKQFKPEQIIEIVAKELNIKTDLIKSSIRKNNIVWARDIVCYILKNKLNLTLTDIGKLLNGREHTTISHSISKVQKILDDENSQEALQINLIINKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q56560</accession>
    <accession>Q9PQ58</accession>
    <name>UREF_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureF</name>
        <name type="ordered locus">UU430</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="647" last="655">
            <title>Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli.</title>
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8550495"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreF family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA89191" version="2"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAF30842" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="L40489">
        <property type="protein sequence ID" value="AAA89191.2"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30842.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E82890">
        <property type="entry name" value="E82890"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689006.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56560"/>
    <dbReference type="SMR" id="Q56560"/>
    <dbReference type="STRING" id="273119.UU430"/>
    <dbReference type="EnsemblBacteria" id="AAF30842">
        <property type="protein sequence ID" value="AAF30842"/>
        <property type="gene ID" value="UU430"/>
    </dbReference>
    <dbReference type="GeneID" id="29672335"/>
    <dbReference type="KEGG" id="uur:UU430"/>
    <dbReference type="eggNOG" id="COG0830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_4_2_14"/>
    <dbReference type="OMA" id="TQYTRLF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0996">Nickel insertion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000067656" description="Urease accessory protein UreF">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA89191." evidence="2" ref="1">
        <original>G</original>
        <variation>R</variation>
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA89191." evidence="2" ref="1">
        <original>MINFQGLARETREG</original>
        <variation>SDKLSRFSKRDSLKV</variation>
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA89191." evidence="2" ref="1">
        <original>DFKTDFCKNIPGLEIAQMEHEDTPVRLFMS</original>
        <variation>ILKQIFAKIYQALKLPNGTLRHTCSIVHVIIKVLVKHYINHKNTILIFLENLKKKEN</variation>
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="235" mass="27147" checksum="74D82BF245BD6603" modified="2008-07-22" version="3">MTLNSDYLNLLDLMQITNANFPIGTFSHSFGVETYIRKDIVFDGESLIKALLLYMNEQLLHGDLLAIYQIFKLLPKQKINAIWEIDQMINFQGLARETREGQRRIGQQMVKIYNELFNCELLVEYAERIKNKKSYGNPAVAFALLAMHLKIDLKTALYTHLYSTVAALTQNCVRAIPLGQVKGQKIIYQLKHVYFDDIVNKVFTLDFKTDFCKNIPGLEIAQMEHEDTPVRLFMS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q56562</accession>
    <accession>Q9PQ60</accession>
    <name>URED_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureD</name>
        <name type="ordered locus">UU428</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="647" last="655">
            <title>Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli.</title>
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8550495"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L40489">
        <property type="protein sequence ID" value="AAA89193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F82893">
        <property type="entry name" value="F82893"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688613.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56562"/>
    <dbReference type="SMR" id="Q56562"/>
    <dbReference type="STRING" id="273119.UU428"/>
    <dbReference type="EnsemblBacteria" id="AAF30840">
        <property type="protein sequence ID" value="AAF30840"/>
        <property type="gene ID" value="UU428"/>
    </dbReference>
    <dbReference type="GeneID" id="29672331"/>
    <dbReference type="KEGG" id="uur:UU428"/>
    <dbReference type="eggNOG" id="COG0829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056339_5_0_14"/>
    <dbReference type="OMA" id="IPFENAH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0996">Nickel insertion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000067618" description="Urease accessory protein UreD">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AAA89193." evidence="2" ref="2">
        <original>I</original>
        <variation>V</variation>
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AAA89193." evidence="2" ref="2">
        <original>DAR</original>
        <variation>AAC</variation>
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2." evidence="2" ref="2">
        <original>A</original>
        <variation>R</variation>
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="287" mass="33247" checksum="97629F1F812C77F1" modified="2000-12-01" version="2">MILNKEKIKNYAAYLYIKVAYDQAHSKMAHTVYFTNFYRSSKPLFLDEEDPINPCFQTISMGGGYVSGEIYRSDFEINDDARCIITTQSSAKAYKTVDGKTSEQHTNITLGKNSILEYISDNVIVYEDGKFAQFNNFKMDSSATLIYTECFGPGWSPHGSAYQYEKMYLNTKIYYDDKLVLFDNLKFQPRKNDESAFGIMDGYHYCGTMIVINQQVIEDDVIKIRDLVKEKYPDMDMIFGVSRMDIPGLGLRVLANTYYHVEKINAVAHDYFRRKLFNKKPLILRKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPN5</accession>
    <name>RL34_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmH</name>
        <name type="synonym">rpl34</name>
        <name type="ordered locus">UU604</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026378.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPN5"/>
    <dbReference type="SMR" id="Q9PPN5"/>
    <dbReference type="STRING" id="273119.UU604"/>
    <dbReference type="EnsemblBacteria" id="AAF31018">
        <property type="protein sequence ID" value="AAF31018"/>
        <property type="gene ID" value="UU604"/>
    </dbReference>
    <dbReference type="GeneID" id="29672317"/>
    <dbReference type="KEGG" id="uur:UU604"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000187498" description="50S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="48" mass="5705" checksum="FAF607B769EA1A96" modified="2000-10-01" version="1">MKRTFQPNNRKRAKVHGFRARMKTKNGRNVLARRRLKGRHSLTVSSEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-12-13" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPN8</accession>
    <name>RSMA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="1">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmA</name>
        <name evidence="1" type="synonym">ksgA</name>
        <name type="ordered locus">UU601</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAF31015" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31015.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E82871">
        <property type="entry name" value="E82871"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688630.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPN8"/>
    <dbReference type="SMR" id="Q9PPN8"/>
    <dbReference type="STRING" id="273119.UU601"/>
    <dbReference type="EnsemblBacteria" id="AAF31015">
        <property type="protein sequence ID" value="AAF31015"/>
        <property type="gene ID" value="UU601"/>
    </dbReference>
    <dbReference type="GeneID" id="29672343"/>
    <dbReference type="KEGG" id="uur:UU601"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_1_14"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000101635" description="Ribosomal RNA small subunit methyltransferase A">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="277" mass="32145" checksum="EC4E13D6B1549BCE" modified="2002-12-13" version="2">MNKSFIKNKLKQESFVPSKKMGQNFLLSNNIKNKIVDVANINKDDLILEIGPGWGAITEILVQKTNILIAIELDKRLYAHLKTYIKTSNFHIINNDVLCVDLDNLILDYNNTQKIQKIKVVANLPYAISSKIVLKIIQSKLINDAYIMVQKEMAERIGAKVNTRGYNAFTVLVQLFCKTKILFEVNAKEFHPQPKVQSAVIHLENLHNSVNFNIEELGKFLRICFLNKRKKLKNNLSNIYDIKIINQMFIDYNLDMNLRAENIEPKMFLKLFNYLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP1</accession>
    <name>Q9PPP1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688577.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU598"/>
    <dbReference type="EnsemblBacteria" id="AAF31012">
        <property type="protein sequence ID" value="AAF31012"/>
        <property type="gene ID" value="UU598"/>
    </dbReference>
    <dbReference type="GeneID" id="29672259"/>
    <dbReference type="KEGG" id="uur:UU598"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.621"/>
    <dbReference type="eggNOG" id="COG1078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_0_0_14"/>
    <dbReference type="OMA" id="ITEKKAY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF31012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="405" mass="48142" checksum="44C2B9E9A487697C" modified="2000-10-01" version="1">MVKNFFIKDPIHGLITFDEQYEWAYELIKTKEFWRLNNIKQLGSSWSIFPSATHTRFTHCIGVFQVTRKLLDSLKFIKSDTHDLINNKKIVCAAALLHDIGHGPFSHTFEYATNYNHEKIGQMIITNPKSEINKILIKHNINPVDVANIIDHKSKKMWMQQVISSQIDADRLDYLPRDSHFTGTKYGNIDYDNIFKKAIVFNDQLCFSKHSWNALENILISRWSMFENVYLNKTPTTYDILMKKTLARVHFLYQKQKKYIFKNSQLLTILKPWLDNESWDITTVQNLDDYSFTALMRSFANEHDFILKTLATNWLQNKDFVTFEYEYGKDKSKDQKIIHKKYFYETITSNKQIYDFNEPVFLYTENKNNDIKLLKLEDKSLIIAALKSIKQPRIKKWIFYYKPLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP2</accession>
    <name>RPOE_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable DNA-directed RNA polymerase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>RNAP delta factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rpoE</name>
        <name type="ordered locus">UU597</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RpoE family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688513.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPP2"/>
    <dbReference type="SMR" id="Q9PPP2"/>
    <dbReference type="STRING" id="273119.UU597"/>
    <dbReference type="EnsemblBacteria" id="AAF31011">
        <property type="protein sequence ID" value="AAF31011"/>
        <property type="gene ID" value="UU597"/>
    </dbReference>
    <dbReference type="GeneID" id="29672359"/>
    <dbReference type="KEGG" id="uur:UU597"/>
    <dbReference type="eggNOG" id="COG3343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1651434_0_0_14"/>
    <dbReference type="OMA" id="ENWIGFF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00357">
        <property type="entry name" value="RNApol_bact_RpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038087">
        <property type="entry name" value="RNAP_delta_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029757">
        <property type="entry name" value="RpoE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04567">
        <property type="entry name" value="RNAP_delt_lowGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000204335" description="Probable DNA-directed RNA polymerase subunit delta">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HTH HARE-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="160" mass="18770" checksum="79B5FCDC7AB5A4CF" modified="2000-10-01" version="1">MSRQLVDIAYNAIKNNKIYNKKPFTFDDIINEIVKNSNVNLVEVNSQLGVLYTTLIQDTRFISIGDLEWNLRERLSLDEITKINNAMYEVGLYKDSDREEDEHEIVKNDKLTQSKEQEESDEVSSLSDFVGYEDEDEEFKNNNTSNKDEIEDEEELEEEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP3</accession>
    <name>ALF_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Fructose-bisphosphate aldolase</fullName>
            <shortName>FBP aldolase</shortName>
            <shortName>FBPA</shortName>
            <ecNumber>4.1.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Fructose-1,6-bisphosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">fba</name>
        <name type="synonym">tsr</name>
        <name type="ordered locus">UU596</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688794.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPP3"/>
    <dbReference type="SMR" id="Q9PPP3"/>
    <dbReference type="STRING" id="273119.UU596"/>
    <dbReference type="EnsemblBacteria" id="AAF31010">
        <property type="protein sequence ID" value="AAF31010"/>
        <property type="gene ID" value="UU596"/>
    </dbReference>
    <dbReference type="GeneID" id="29672322"/>
    <dbReference type="KEGG" id="uur:UU596"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_14"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
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        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000178754" description="Fructose-bisphosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
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        <ligand>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="290" mass="31713" checksum="BD32AB69AE5FE341" modified="2000-10-01" version="1">MSPLVNAKKMIQNAYENHYAVAAININNLEWIKAALLAAQETNSPLLLATSEGAVKYMGGYDNCYAMVVNLIKQMNIKTPVCLHLDHGTYEGCIKAINAGYSSIMYDGSKLSIEENIKNTKELLTITKLKGVSVEVEVGSIGGTEDGITSEGELANIDDCYQMCLLDIDMLACGIGNIHGIYPKNWKGLNFNLLKEINNKVNKPIVLHGGSGISDEQILKAINLGVAKININTECQIAFSNALQDHLTKAGDLILSKQYDPRKILAYGVDAIKNTIIDKFTKFNSLNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ2</accession>
    <name>Q9PPQ2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphohistidinoprotein-hexose phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ptsH</name>
        <name evidence="2" type="ordered locus">UU587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688423.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU587"/>
    <dbReference type="EnsemblBacteria" id="AAF31001">
        <property type="protein sequence ID" value="AAF31001"/>
        <property type="gene ID" value="UU587"/>
    </dbReference>
    <dbReference type="GeneID" id="29672362"/>
    <dbReference type="KEGG" id="uur:UU587"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.610"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_2_2_14"/>
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    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF31001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="87" mass="9387" checksum="990682E168FEF577" modified="2000-10-01" version="1">MISKEFTIVAELSAFIKAITYFVNAASDFSSSITIKANGRQADAKSIINIMALGIKQGTKIELSAVGNDANKAINKLEEILIEQKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ6</accession>
    <name>Q9PPQ6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA damage inducible protein-MATE transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="3" type="ordered locus">UU583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU583"/>
    <dbReference type="EnsemblBacteria" id="AAF30997">
        <property type="protein sequence ID" value="AAF30997"/>
        <property type="gene ID" value="UU583"/>
    </dbReference>
    <dbReference type="GeneID" id="29672295"/>
    <dbReference type="KEGG" id="uur:UU583"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.606"/>
    <dbReference type="eggNOG" id="COG0534">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040650_0_0_14"/>
    <dbReference type="OMA" id="FYWRMVS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="534" mass="61035" checksum="73B30293D17CB850" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS7</accession>
    <name>Q9PPS7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689058.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU563"/>
    <dbReference type="EnsemblBacteria" id="AAF30976">
        <property type="protein sequence ID" value="AAF30976"/>
        <property type="gene ID" value="UU563"/>
    </dbReference>
    <dbReference type="GeneID" id="29672645"/>
    <dbReference type="KEGG" id="uur:UU563"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.585"/>
    <dbReference type="HOGENOM" id="CLU_1776666_0_0_14"/>
    <dbReference type="OMA" id="FIAYTCI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="146" mass="17597" checksum="01678E52CBCBF55E" modified="2000-10-01" version="1">MSIKKQSFPNRLLNYKSIIVLIALLILMVISHLIVELIKDYHQYRMNVFIAYTCIFMVVFLYIIFSRQVYRRRWAVKLRKYNEYKLSSWEMKLVDRFYINAKYELRSIDYATIRLNILITIIILPSFIYALACMIAYIIKTTQSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT1</accession>
    <name>Q9PPT1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppF</name>
        <name evidence="6" type="ordered locus">UU559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/35037619"/>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="439" mass="50253" checksum="CB2E60726E551574" modified="2000-10-01" version="1">MSDTNQKKAFFNHKKRFCLPDKITIRPVTEGLIERLNANPEKKRLVQVRHLDVTYGHGFKKFRAVKDISFNIYQGEVLGLVGESGSGKSTTGSALIGLARHSFGDIIIDGIKLPKQGEKVTKELTDFMVNNVQMIFQDPSNSLNPYVNIETVVSEGLNNIKDLKKSFLRLIYKDYLRGLKKELKAKNFLNNEQVQIFLEKAQDLKFDYLNETAQQELIQLFNELELNHLSLDNNDEKLQKAFNDINTWKSKTRTDITRHLILDVLKSVGLDETVLRRYPLEFSGGQQQRIGISRAVALRPKLLIADEPISALDVSIQAQVVNIFKELKTKYDLTILFIAHDLRMVEYISDRIAVMNKGVLLEIGPTKEIVNNFLHPYTRSLMEAVPSIDSEKKSLLGYVYDANMHEYTPTKQPKWIHLGNDHYILGTDEEIANWKAGKY</sequence>
</entry>
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    <reference evidence="2 3" key="1">
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            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
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                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
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            </authorList>
            <dbReference type="PubMed" id="11048724"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1883" mass="216721" checksum="0DB20555DFEB0114" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU1</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="588" mass="67041" checksum="2B022EF1F581D759" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU4</accession>
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            <dbReference type="PubMed" id="11048724"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AAF30959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="94" mass="11068" checksum="CE668888C4D2F64D" modified="2000-10-01" version="1">MSYNLQKLMSSCMFILTDDEIKQVENRLNNLFNEIKVFELFNLQNITPFEIINKSFDNFLREDEINSCVGNNSEEVLNNCLKVIDHYGVLKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU7</accession>
    <name>Q9PPU7_UREPA</name>
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        <submittedName>
            <fullName evidence="9">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ordered locus">UU543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Mollicutes</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
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                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
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            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU543"/>
    <dbReference type="EnsemblBacteria" id="AAF30956">
        <property type="protein sequence ID" value="AAF30956"/>
        <property type="gene ID" value="UU543"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU543"/>
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    </dbReference>
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    <dbReference type="OMA" id="YLQYPWR"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
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        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1282"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1327"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1359"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="8">
        <location>
            <begin position="504"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="8">
        <location>
            <begin position="600"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1413" mass="163145" checksum="5977714BB3B0D969" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU8</accession>
    <name>Q9PPU8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU542"/>
    <dbReference type="EnsemblBacteria" id="AAF30955">
        <property type="protein sequence ID" value="AAF30955"/>
        <property type="gene ID" value="UU542"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU542"/>
    <dbReference type="HOGENOM" id="CLU_348812_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="808" mass="96179" checksum="C8E57B21CA284B70" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-28" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV4</accession>
    <name>TRUA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="1">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truA</name>
        <name type="synonym">hisT</name>
        <name type="ordered locus">UU536</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689087.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPV4"/>
    <dbReference type="SMR" id="Q9PPV4"/>
    <dbReference type="STRING" id="273119.UU536"/>
    <dbReference type="EnsemblBacteria" id="AAF30949">
        <property type="protein sequence ID" value="AAF30949"/>
        <property type="gene ID" value="UU536"/>
    </dbReference>
    <dbReference type="GeneID" id="29672419"/>
    <dbReference type="KEGG" id="uur:UU536"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_14"/>
    <dbReference type="OMA" id="KGVHANN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000057482" description="tRNA pseudouridine synthase A">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <sequence length="241" mass="28198" checksum="3F37E6B00C79CF51" modified="2000-10-01" version="1">MNYKISLRYDGSLFYGWARQPQKRTVQGDLEEIFKSIFKINNIRIIGSGRTDKGVHAYEQTFSVKHSALKYDSHIIYQALCSRTSSDIQILEVQKVDDSFHAQYNATSKTYQYVINDYEFDLFRNNYELFVNQKINDQKILEALELFVGEHDFKSFSTSELTMTIRRINWVKIKRDTHLIIYINANGFLKNMVRMIVASCLDYAFNKISLAKIHELLIYPKKGASIKLAPACGLYLYKVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW1</accession>
    <name>Q9PPW1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase-recombinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">codV</name>
        <name evidence="3" type="ordered locus">UU529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688485.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30942">
        <property type="protein sequence ID" value="AAF30942"/>
        <property type="gene ID" value="UU529"/>
    </dbReference>
    <dbReference type="GeneID" id="29672384"/>
    <dbReference type="KEGG" id="uur:UU529"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.549"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097635_0_0_14"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="251" mass="29696" checksum="63C0829EC4F2003F" modified="2000-10-01" version="1">MKKFINYLKNVKGYSDGTIAIYQKYVKVLIDNNLDYLKAIKKYEHNANVTKRVVLSAFKAYLKFINHKDAILIVMPKKEIKVKEFLTWDNFLKIINNINQATFLGFQKYLILRILFETGIRSCELLKLEIKDIYENKLKIHGKGKKERFVYLSNDLQNNIKKYIGQIKTKYLFNFSYKNLYQKVTRIKTNIRLTPHILRRSFANHCINNGINIYDLSLVMGHNNINSTSLYLNKESKLVELDHLFDNKKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW3</accession>
    <name>Q9PPW3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891809.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU527"/>
    <dbReference type="EnsemblBacteria" id="AAF30940">
        <property type="protein sequence ID" value="AAF30940"/>
        <property type="gene ID" value="UU527"/>
    </dbReference>
    <dbReference type="GeneID" id="29672371"/>
    <dbReference type="KEGG" id="uur:UU527"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.547"/>
    <dbReference type="eggNOG" id="COG1479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304379_0_0_14"/>
    <dbReference type="OMA" id="CETVEIF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="1">
        <location>
            <begin position="312"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="771"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="971" mass="116144" checksum="F4541E7456751954" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW8</accession>
    <name>Q9PPW8_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligoendopeptidase F</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF-2</name>
        <name evidence="9" type="ordered locus">UU521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has oligopeptidase activity and degrades a variety of small bioactive peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688433.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU521"/>
    <dbReference type="EnsemblBacteria" id="AAF30934">
        <property type="protein sequence ID" value="AAF30934"/>
        <property type="gene ID" value="UU521"/>
    </dbReference>
    <dbReference type="GeneID" id="29672339"/>
    <dbReference type="KEGG" id="uur:UU521"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.541"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_2_0_14"/>
    <dbReference type="OMA" id="YRQTMFA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="113"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="199"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="611" mass="72474" checksum="09E7B0512B8CB863" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY9</accession>
    <name>Q9PPY9_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">uvrD</name>
        <name evidence="9" type="ordered locus">UU501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688638.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU501"/>
    <dbReference type="EnsemblBacteria" id="AAF30913">
        <property type="protein sequence ID" value="AAF30913"/>
        <property type="gene ID" value="UU501"/>
    </dbReference>
    <dbReference type="GeneID" id="29672622"/>
    <dbReference type="KEGG" id="uur:UU501"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.518"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_14"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="294"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="743" mass="86741" checksum="9D412574673D71E7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ02</accession>
    <name>APT_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="1">APRT</shortName>
            <ecNumber evidence="1">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apt</name>
        <name type="ordered locus">UU488</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688428.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ02"/>
    <dbReference type="SMR" id="Q9PQ02"/>
    <dbReference type="STRING" id="273119.UU488"/>
    <dbReference type="EnsemblBacteria" id="AAF30900">
        <property type="protein sequence ID" value="AAF30900"/>
        <property type="gene ID" value="UU488"/>
    </dbReference>
    <dbReference type="GeneID" id="29672626"/>
    <dbReference type="KEGG" id="uur:UU488"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_14"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000149482" description="Adenine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <sequence length="173" mass="19245" checksum="AF2540B27F08E2FF" modified="2000-10-01" version="1">MINIDYIKSKIRDVPDFPKKGIVFKDITPLFLEPKIIEKIVDDFADFAKSLNIDAIIGAESRGFLFAAPLSIKLNKPFILVRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVRQAKGIVAGSVYLIRLGFLKGEEKLSGKVHALINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ06</accession>
    <name>Q9PQ06_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ackA</name>
        <name evidence="8" type="ordered locus">UU484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688690.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU484"/>
    <dbReference type="EnsemblBacteria" id="AAF30896">
        <property type="protein sequence ID" value="AAF30896"/>
        <property type="gene ID" value="UU484"/>
    </dbReference>
    <dbReference type="GeneID" id="29672525"/>
    <dbReference type="KEGG" id="uur:UU484"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.501"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_0_14"/>
    <dbReference type="OMA" id="IHYLYSI"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="387" mass="44587" checksum="A98DF1FF50FB3905" modified="2000-10-01" version="1">MMLIINIGSSSWKFCLFDMNLKQIFSGKIRLDVSPHQLKYIFDKNEYVYLLDDDHNNHVDLIIKFLINKKIIKKLEDITYFGIRAVYVKNFYGASAFLNNEIYNDLNQHTDLCPIHNQNTIMLINDIKHLNTSAKIIIIFDNWFHRSINKNKYTIAIDQTIAIKHKIRKYGFHGISFSYSNKIMQNYLGKQDVNLIILHLGSGSSVCAIKNGKSFDTSMSYSPLSGIIMNTRSGDIDPSVLLTLKKVKNQSLKQLILFLNQQSGLYGLTKHHSISEVANNLHNKNNELALEMYTDSIVDYFIKYLNHLQKIDAIVFSGGISEFEHLVLEKIISKIHLINLEINDHLILTNTLNKISTSKSQIPIYLCLVNEEHEIAYEMLNLINKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ11</accession>
    <name>Q9PQ11_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891793.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30891">
        <property type="protein sequence ID" value="AAF30891"/>
        <property type="gene ID" value="UU479"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU479"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.495"/>
    <dbReference type="HOGENOM" id="CLU_295249_0_0_14"/>
    <dbReference type="OMA" id="MSATINY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="119"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="413"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1025" mass="119060" checksum="61257602CA5FA1B4" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ21</accession>
    <name>NNAAH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable nicotinate-nucleotide adenylyltransferase/Ap4A hydrolase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Nicotinate-nucleotide adenylyltransferase</fullName>
                <ecNumber evidence="1">2.7.7.18</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Deamido-NAD(+) diphosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Deamido-NAD(+) pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Nicotinate mononucleotide adenylyltransferase</fullName>
                <shortName evidence="1">NaMN adenylyltransferase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase, symmetrical</fullName>
                <ecNumber evidence="2">3.6.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="2">Ap4A hydrolase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name type="primary">nadD</name>
        <name type="ordered locus">UU469</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="function">
        <text evidence="2">Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield ADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the NadD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the Ap4A hydrolase YqeK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="1"/>
    <dbReference type="EC" id="3.6.1.41" evidence="2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688791.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ21"/>
    <dbReference type="SMR" id="Q9PQ21"/>
    <dbReference type="STRING" id="273119.UU469"/>
    <dbReference type="PRIDE" id="Q9PQ21"/>
    <dbReference type="EnsemblBacteria" id="AAF30881">
        <property type="protein sequence ID" value="AAF30881"/>
        <property type="gene ID" value="UU469"/>
    </dbReference>
    <dbReference type="GeneID" id="29672541"/>
    <dbReference type="KEGG" id="uur:UU469"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050191_0_0_14"/>
    <dbReference type="OMA" id="FHDICKE"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008803">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000181465" description="Probable nicotinate-nucleotide adenylyltransferase/Ap4A hydrolase">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="232"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="NaMN adenylyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ap4A hydrolase" evidence="5">
        <location>
            <begin position="230"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="266"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="326"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q2G297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9KD90"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="392" mass="46645" checksum="4897A34B2876725C" modified="2000-10-01" version="1">MKIILFCGAFDMVHNAHIAMAKQAMKLVNADKLIFLPSNFKFFKAINKNDNLEYEKTKLTPGHHRIAMLKIATKNLVNIEVSDYELKQINKSYTINTIEHFKQIYGSEHEYYFIMGSDNLERFKQWKDWERILKEVKIICFKRGDVCVKKSCPQKSCECESFNFFEHEILLVNDFNYNISSTEIKKRHNLTSGIDPAVLDYINEHGLYALWLLEKHLISYDNFNNLEKKVARINHCRRVAQMCVDLMNVYDKKLIDQAYCAGIYHDILKCLDEQESVAYFNEHKSELNIGDDFISWRILHSYLGAHLLQTQYGFKNQLILNAIRRHTRPFDFIKDYSELTTLDKILYCADKLEPNRREEIDQINIDYYRKLVFEDLDKAFIEVYQYQQRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ31</accession>
    <name>Q9PQ31_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688722.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU459"/>
    <dbReference type="EnsemblBacteria" id="AAF30871">
        <property type="protein sequence ID" value="AAF30871"/>
        <property type="gene ID" value="UU459"/>
    </dbReference>
    <dbReference type="GeneID" id="29672717"/>
    <dbReference type="KEGG" id="uur:UU459"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.475"/>
    <dbReference type="HOGENOM" id="CLU_1694748_0_0_14"/>
    <dbReference type="OMA" id="SYYVEDY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="156" mass="18839" checksum="E50C5FAA78412CA7" modified="2000-10-01" version="1">MNNKKGKKFYDFLKTIEGFKIITIISYVFVAILLAILIWSAVRLSYYIKDYYARIDEYNEWKQNIIKIFKTKNFHLDSPYNQIKIFKYGSILGISSFLIIIININIFAYWSYSNVYIPELKDKKLVKNWFRNFQKNNKEDQKVIKDQQEDTKKESE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-08" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ33</accession>
    <name>SYFB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber>6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName>PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pheT</name>
        <name type="ordered locus">UU457</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891780.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ33"/>
    <dbReference type="SMR" id="Q9PQ33"/>
    <dbReference type="STRING" id="273119.UU457"/>
    <dbReference type="EnsemblBacteria" id="AAF30869">
        <property type="protein sequence ID" value="AAF30869"/>
        <property type="gene ID" value="UU457"/>
    </dbReference>
    <dbReference type="GeneID" id="29672674"/>
    <dbReference type="KEGG" id="uur:UU457"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.473"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_2_0_14"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126980" description="Phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="B5">
        <location>
            <begin position="397"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB">
        <location>
            <begin position="691"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="772" mass="88192" checksum="CCBE070438AEB6E6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ35</accession>
    <name>Q9PQ35_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU455"/>
    <dbReference type="EnsemblBacteria" id="AAF30867">
        <property type="protein sequence ID" value="AAF30867"/>
        <property type="gene ID" value="UU455"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU455"/>
    <dbReference type="HOGENOM" id="CLU_279390_0_0_14"/>
    <dbReference type="OMA" id="PANWANI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331064" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1132" mass="130917" checksum="8F7325D805460DEE" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ54</accession>
    <name>Q9PQ54_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hlyA</name>
        <name evidence="4" type="ordered locus">UU436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TlyA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689051.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU436"/>
    <dbReference type="EnsemblBacteria" id="AAF30848">
        <property type="protein sequence ID" value="AAF30848"/>
        <property type="gene ID" value="UU436"/>
    </dbReference>
    <dbReference type="GeneID" id="29672416"/>
    <dbReference type="KEGG" id="uur:UU436"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.452"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_3_0_14"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="3">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="247" mass="28500" checksum="70FE05294C523E0C" modified="2000-10-01" version="1">MNQRLDHYLKNTNQCETRSKAIDLIKRGRVFVNNFQVLKPSFLVKQTDSVEIKNDEMYFVSKGGYKLLKIIKEINLIIKNFVIADLGSSTGGFTDCCLQLGAKKIYAIDVGVDLLHPSLKKSYKIINYEKTNVKNLDKSYFLEDLDLIVGDLSFISLEQIFPIIKKISSPKTLLLLLIKPQFELGKDVASKYKGLIQNQKLQQLAINKIINLAKNYDFECKHLTPTDIFDEKKQNQEYMIFLQKHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ65</accession>
    <name>Q9PQ65_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU424"/>
    <dbReference type="EnsemblBacteria" id="AAF30835">
        <property type="protein sequence ID" value="AAF30835"/>
        <property type="gene ID" value="UU424"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU424"/>
    <dbReference type="eggNOG" id="ENOG502ZGNK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1034210_0_0_14"/>
    <dbReference type="OMA" id="LLMMYIT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024503">
        <property type="entry name" value="DUF3196"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11428">
        <property type="entry name" value="DUF3196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="269" mass="31741" checksum="7FC5A78F974AD7F6" modified="2000-10-01" version="1">MVCIILKIKKGMLKIMNNNKSYIKKYFDDILIQAKQVLKKHDYAYAYDLISNEFNNPLIDLKTLQEFEAFAIEIKKSAELNFIDENEAKLAKTDFYCKIHDPKTTYVSLAYLETFLMRFINEMDELDITFLNSLLTNKLINGSTKLDILDLLATNNIDQNFNFYNKYLKQTKNVNPVNFNNHYQEIDQIQNYLNKYLAKNPSLLHLANKLLMMYITYYFPFKFAHNHNLIAKTIIDYVKNAMENHVCQYSEEQKAIVACINKILEEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ66</accession>
    <name>Q9PQ66_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688560.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU423"/>
    <dbReference type="EnsemblBacteria" id="AAF30834">
        <property type="protein sequence ID" value="AAF30834"/>
        <property type="gene ID" value="UU423"/>
    </dbReference>
    <dbReference type="GeneID" id="29672696"/>
    <dbReference type="KEGG" id="uur:UU423"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.439"/>
    <dbReference type="eggNOG" id="COG3557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175029_0_0_14"/>
    <dbReference type="OMA" id="QSYKHNG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="236" mass="28490" checksum="850248DF40A921ED" modified="2000-10-01" version="1">MQEKKQTKNENFQDLDQLKIGDELMVHAYKLNGWLYRSWNNPKVVYIDDQLLILSSTNTLVITSEEKSVRNFPSFTNKMSYWFFFKNEWFNLIATVENDGIKFYINVASPFIYEEQAVKYYDFDLDFKISSDDKWKEVDVNEFIENAKKYHYSEDLIQKILSVETKIENYIKEGYFRKLVTRQLLIKLHVLDDIDDFKTNFNKHTNEWNYNLKKHFNKKNGLHHFKNKKGNVKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ67</accession>
    <name>Q9PQ67_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688424.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU422"/>
    <dbReference type="EnsemblBacteria" id="AAF30833">
        <property type="protein sequence ID" value="AAF30833"/>
        <property type="gene ID" value="UU422"/>
    </dbReference>
    <dbReference type="GeneID" id="29672635"/>
    <dbReference type="KEGG" id="uur:UU422"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.438"/>
    <dbReference type="HOGENOM" id="CLU_1593844_0_0_14"/>
    <dbReference type="OMA" id="WHNITIP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="167" mass="20687" checksum="CAC7C0F9A6D7DDC1" modified="2000-10-01" version="1">MNIKKIKREFNTHYELIKKEIKNLNEYKKELEFLIATIYFNSKMVFKEISLDSWKKFSDYVYRFFLIINKNNQSQNFDLDCWYLEIKELIKVLNISNFLLNKQLEQIYLKYIIFYWYNINIPINYEIDDFNIICLRNKAFVDCMQILQEYYHINVDILINLVIKQIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-04-03" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ71</accession>
    <name>THII_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="1">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiI</name>
        <name type="ordered locus">UU418</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689025.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ71"/>
    <dbReference type="SMR" id="Q9PQ71"/>
    <dbReference type="STRING" id="273119.UU418"/>
    <dbReference type="PRIDE" id="Q9PQ71"/>
    <dbReference type="EnsemblBacteria" id="AAF30829">
        <property type="protein sequence ID" value="AAF30829"/>
        <property type="gene ID" value="UU418"/>
    </dbReference>
    <dbReference type="GeneID" id="29672603"/>
    <dbReference type="KEGG" id="uur:UU418"/>
    <dbReference type="eggNOG" id="COG0301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_0_14"/>
    <dbReference type="OMA" id="SMPEFCG"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000154883" description="Probable tRNA sulfurtransferase">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="THUMP" evidence="1">
        <location>
            <begin position="60"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <sequence length="390" mass="44316" checksum="EC527C009663058D" modified="2000-10-01" version="1">MKPIIYIKYGELTLKGKNRTQFIKVLVHNIKQILIQYQNLTYCVGYDNLKIINLENYNLKQIIDDLKEVYGIAFICIAYQVDKELSEIQLACKEFINDYEQTFKIEARRSDKSFKYNSMEIKQMCAAYLLQNSPLLKVDVHRPQLLINIEIKYDCAIVYGHKIMGAKGLPVGINGKALVLLSGGIDSPVASRLIMKRGISIDFITFITPPHTSQKALDKTIALAKQITLDNKLTKANLYVCNFTKLQDEIAHISKESYRITLMRRYFMRIAKRLAISVKANALVTGEALGQVASQTLNSMQTISSVLDNFLVLRPLIAYDKEEIISLAKRFNTYELSILPYDDSCSLFAPKNPTTNPNVQTAAKLEEESLVLDAIYELVYTKEITKINLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ74</accession>
    <name>DPO3A_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA polymerase III subunit alpha</fullName>
            <ecNumber>2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dnaE</name>
        <name type="ordered locus">UU415</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-C family. DnaE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688481.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ74"/>
    <dbReference type="SMR" id="Q9PQ74"/>
    <dbReference type="STRING" id="273119.UU415"/>
    <dbReference type="EnsemblBacteria" id="AAF30826">
        <property type="protein sequence ID" value="AAF30826"/>
        <property type="gene ID" value="UU415"/>
    </dbReference>
    <dbReference type="GeneID" id="29672555"/>
    <dbReference type="KEGG" id="uur:UU415"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_0_1_14"/>
    <dbReference type="OMA" id="MMREYIL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000103357" description="DNA polymerase III subunit alpha">
        <location>
            <begin position="1"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="969" mass="112344" checksum="0569486460E2960B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ76</accession>
    <name>FPG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="2">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="2">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="2">AP lyase MutM</shortName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mutM</name>
        <name evidence="2" type="synonym">fpg</name>
        <name type="ordered locus">UU413</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="2"/>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689001.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ76"/>
    <dbReference type="SMR" id="Q9PQ76"/>
    <dbReference type="STRING" id="273119.UU413"/>
    <dbReference type="EnsemblBacteria" id="AAF30824">
        <property type="protein sequence ID" value="AAF30824"/>
        <property type="gene ID" value="UU413"/>
    </dbReference>
    <dbReference type="GeneID" id="29672493"/>
    <dbReference type="KEGG" id="uur:UU413"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_3_14"/>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000170881" description="Formamidopyrimidine-DNA glycosylase">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FPG-type" evidence="2">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <sequence length="275" mass="31993" checksum="9F4624E870E5AF6A" modified="2007-01-23" version="3">MPELPEVQTIVDYLNHHVLDIFIKKTIVHLPKILKNKTPQEFEKLLINHKIVKIKRLGKYLLFFLSNNLVLSVHLRMEGKFYYQAKEEWFNLAHTHIIIEFNNGMQLRYNDTRQFGTFHIYEQQSFLDSKELKKIALDPLDNNFSAQYLYEKLKKSNKAIKTALLDQSVVSGIGNIYADEILFAAKIFPTILAKNLTLKNYEKITKEAQRILLLSIKNKGTTIHTYKFGNDETGLFQKMLLVHTHAKEPCQICGTIIQKTKVNGRGTYYCPNCQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ79</accession>
    <name>SYI_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="1">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ileS</name>
        <name type="ordered locus">UU410</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688542.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ79"/>
    <dbReference type="SMR" id="Q9PQ79"/>
    <dbReference type="STRING" id="273119.UU410"/>
    <dbReference type="PRIDE" id="Q9PQ79"/>
    <dbReference type="EnsemblBacteria" id="AAF30821">
        <property type="protein sequence ID" value="AAF30821"/>
        <property type="gene ID" value="UU410"/>
    </dbReference>
    <dbReference type="GeneID" id="29672433"/>
    <dbReference type="KEGG" id="uur:UU410"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_1_14"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000098496" description="Isoleucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="593"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <sequence length="900" mass="105806" checksum="FA478902AE347D87" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ84</accession>
    <name>Q9PQ84_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU405.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688697.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU405.1"/>
    <dbReference type="EnsemblBacteria" id="AAF30816">
        <property type="protein sequence ID" value="AAF30816"/>
        <property type="gene ID" value="UU405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="29672337"/>
    <dbReference type="KEGG" id="uur:UU405.1"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.421"/>
    <dbReference type="eggNOG" id="ENOG502ZTW3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692510_0_0_14"/>
    <dbReference type="OMA" id="TINWMIL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011631">
        <property type="entry name" value="DUF1600"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07667">
        <property type="entry name" value="DUF1600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="398" mass="47349" checksum="90C7882DD9B42FFC" modified="2000-10-01" version="1">MINNKKFINKTFDNTNQIRLQNNLKTYAPKFLNLIIINNIFVLIMIISLCIFFSDPHFLYRNDVISNQYRQFIFTYQQTAIAIVLYVLAWYIMVNFFFFGYLLEYVKLNKFETFNFALASILFNPYAYVIIVKNWTSWSFYWQRSFYHVLSENNKIEFNIKNSKTIFALVFLIIAIPFIIFSSIDYVPKNPGRLIIFNKNSLGEKVIYTNNVWFHNMHYFTSQGNWMCIGIAFLYFINPKARCTKNNRVLLIVLSYILIISSIWLCVLFPMFSRQSTWVWFNNMVGFYNHLITPISFTIFAYYCIIKNKYAIHIKYFYAWKGFMFYVVIYAMYALFLPLLANVTVYGAITNIWPSANGNPIFVTMLFALIGYQILVFSINWTILKFINKYKNNKILIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ86</accession>
    <name>Q9PQ86_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tnp-2</name>
        <name evidence="7" type="ordered locus">UU404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688478.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU404"/>
    <dbReference type="EnsemblBacteria" id="AAF30814">
        <property type="protein sequence ID" value="AAF30814"/>
        <property type="gene ID" value="UU404"/>
    </dbReference>
    <dbReference type="GeneID" id="29672332"/>
    <dbReference type="KEGG" id="uur:UU404"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.419"/>
    <dbReference type="eggNOG" id="COG3328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038049_0_0_14"/>
    <dbReference type="OMA" id="RDRENIF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="268" mass="32411" checksum="1B22AF8526805C17" modified="2000-10-01" version="1">MDKKNIFTILEKLVKKYKYLHKPILDDYISTFTRTFLEYILTIEMKYHLNYERFERYLSSNSKNYRNGFSKKQLYMNDLKVSINIPRDRNGAFESKIISKYQVDISHFEYRLLSLGINNLQLNEYEKILEDIYNIYNDKMVDKLCNEIALKIFDYLENKKQELNNIDVDQIFIDGFNLSSNKWLTIVITKDLEKRLTILGFWVINNLEDKWWNDIIIKISKYHPQVINYKVIFKDNDELLMSLKNHTSNNFERARFVFINKSILNQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ98</accession>
    <name>Q9PQ98_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688987.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU392"/>
    <dbReference type="EnsemblBacteria" id="AAF30802">
        <property type="protein sequence ID" value="AAF30802"/>
        <property type="gene ID" value="UU392"/>
    </dbReference>
    <dbReference type="GeneID" id="29672550"/>
    <dbReference type="KEGG" id="uur:UU392"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.407"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029433_1_0_14"/>
    <dbReference type="OMA" id="WQIYSWL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="594" mass="70245" checksum="AC0A5EB5FDD327E4" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-27" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA4</accession>
    <name>RSMH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">UU386</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891758.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQA4"/>
    <dbReference type="SMR" id="Q9PQA4"/>
    <dbReference type="STRING" id="273119.UU386"/>
    <dbReference type="EnsemblBacteria" id="AAF30796">
        <property type="protein sequence ID" value="AAF30796"/>
        <property type="gene ID" value="UU386"/>
    </dbReference>
    <dbReference type="GeneID" id="29672233"/>
    <dbReference type="KEGG" id="uur:UU386"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.401"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_2_0_14"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000108740" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="308" mass="35557" checksum="1A9E72E9A95A746B" modified="2000-10-01" version="1">MEFNQHITVLLNETIELLNIKPDGIYVDCTFGRGGHSQLILKKLSKKGKLICLDQDQEAINFANNLFKNNTNVIVIKTNFKNLKSALSAHKIFYVDGFIFDLGLSSPQLDDPKRGFSYHKNAWLDMRMDQSQNLNAHYIVNNYSFAKLVSIFKRYGEIKYPKIIADAIVKERSIKEINTTLELVEIIKKYSPKKNLFEKKHPARLFFQAIRIEVNDELNILEKAFNDAISMLNPLGVVAIISFHSLEDKIVKKVFNNYAKIKLPKEVPINNYVNKYSLLNQKIMPSTQELNDNNRSRSSILRGLIRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA6</accession>
    <name>Q9PQA6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">UU384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688634.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU384"/>
    <dbReference type="EnsemblBacteria" id="AAF30794">
        <property type="protein sequence ID" value="AAF30794"/>
        <property type="gene ID" value="UU384"/>
    </dbReference>
    <dbReference type="GeneID" id="29672286"/>
    <dbReference type="KEGG" id="uur:UU384"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.399"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064742_0_0_14"/>
    <dbReference type="OMA" id="LATWIPY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="120"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="365" mass="43454" checksum="95ACC321A1405993" modified="2000-10-01" version="1">MINNLFKTKNYYISFLILATSIACCFYYNNFWILIVNICQFYWLYSIKFNYKIIILIIIFSALCIILCLLIHKDFNIHFLVINIEKKYNYSLRTQILIYLSKKYSNENTLMLIKLMIFNEKINSDFKQILYDLNIAHLFIVSGLHLNLFILIINKIFSKRWPKTSFLIGILFLLFYGYLLEFSIGFIRVFIMHILSIKFFQKISKMDKLAISGMLIGCLSIYNLSILSFIFAYLALFCIYLINIFIKNNSVLKNIYINLYILSITFVISINLNQKINFLSIVFGYVMNLPILFVYQILFWLMFIPHFELILDLFTNTLVKSIYFISEIDASILIKAYVKIVTIFYTTIWITTSLWIYYKKILKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC4</accession>
    <name>Q9PQC4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688803.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU367"/>
    <dbReference type="EnsemblBacteria" id="AAF30776">
        <property type="protein sequence ID" value="AAF30776"/>
        <property type="gene ID" value="UU367"/>
    </dbReference>
    <dbReference type="GeneID" id="29672222"/>
    <dbReference type="KEGG" id="uur:UU367"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.381"/>
    <dbReference type="eggNOG" id="COG4487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034837_1_0_14"/>
    <dbReference type="OMA" id="HCETEFN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019219">
        <property type="entry name" value="DUF2130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09903">
        <property type="entry name" value="DUF2130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005850">
        <property type="entry name" value="UCP005850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="507" mass="60110" checksum="353B146331221E49" modified="2000-10-01" version="1">MKTTANKKIKLINIEKLEFEILEPINTNEILVFKDENSTIYESFNQNLEKQRDEFIKKIREEEEQNWRNNFLANDRDYNELVKQRYDLEKQRDELKEKLKNEGNKAIAHFKDSDEYKNLIKAQEKINSLNKTIESNEQSYKKEIENIELKLKSQFDEETKSLKNTIAKQEIKLDNAEKMAIINFKESNEYQKIIKDKIDLDIEIEKLKFAIQAHEDNMKAAKENWESKKIVEIKELESKKDKEIHKLTESIEQLKREKSSNVKLVGEELEQWLKNKFDETYSFSCPDMTFTKINEAIDGKKADFLLEFFDFGKEMSNDDKKLIFSATIEAKTEFFDNQKGTKNSAHYKKLDQDRINQKSEYAILVTELEPEDHFVIKKINEYKNMFAVRPQYFIPLVDMIRNFATLKAKINSQIIRYEDRAKIEENLDELKKDIVDNTLKYINDKTKKIIDDSKAIIKKAESIEESAEDIINKKLNTLKKKINELTIRKIDPNKLLLEVSDDENDEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE9</accession>
    <name>KCY_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
            <shortName evidence="1">CK</shortName>
            <ecNumber evidence="1">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine monophosphate kinase</fullName>
            <shortName evidence="1">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmk</name>
        <name type="ordered locus">UU342</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688521.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQE9"/>
    <dbReference type="SMR" id="Q9PQE9"/>
    <dbReference type="STRING" id="273119.UU342"/>
    <dbReference type="EnsemblBacteria" id="AAF30751">
        <property type="protein sequence ID" value="AAF30751"/>
        <property type="gene ID" value="UU342"/>
    </dbReference>
    <dbReference type="GeneID" id="29672439"/>
    <dbReference type="KEGG" id="uur:UU342"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_14"/>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000131996" description="Cytidylate kinase">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <sequence length="224" mass="25618" checksum="AEEF7DFF423DADFF" modified="2000-12-01" version="1">MKKYISIAIDGPSGSGKSTAAKELAKKLGFLYINTGLMYRAYAYFLSINKLDINVNEMDCINAIKNANFIFNGDNVKINDNDVSLILRSNDVAMIASVVSANEKIRDLATNEQRRIASENNVVMDGRDIGSIVLTNADLKFYLNTSIQTRAKRRLFQNKDIENLDYESIYNDIKERDHRDMTRKIAPLKKANDAVEIFNDNMKLDECVQHLYEIYLKKIKKLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF5</accession>
    <name>Q9PQF5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891736.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU336"/>
    <dbReference type="EnsemblBacteria" id="AAF30745">
        <property type="protein sequence ID" value="AAF30745"/>
        <property type="gene ID" value="UU336"/>
    </dbReference>
    <dbReference type="GeneID" id="29672423"/>
    <dbReference type="KEGG" id="uur:UU336"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.350"/>
    <dbReference type="HOGENOM" id="CLU_629943_0_0_14"/>
    <dbReference type="OMA" id="NRYRING"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="435" mass="51434" checksum="241FB4EBAA7A2DCE" modified="2000-10-01" version="1">MNKTNQIVDLLTNKQNNSIQRRDNLVFVKNEQEFKDILDSTISLSNVYDPLLGNGCEQEKIKELTILNNSVDISKIEEYTKTLESKVDDLYNNVSNQLIQDYQKNENTSANNIIMKNEELLNSHLKEVEKICEQLIDEWKIEILGEVNFKFQQQLIEIDQKQEHKLKVKSLINEDSFLTKRQVKNKNKILTEFEKHRSQITQNYLNKRSDILKKEYDELLKDDKLFELSSGDNWNNFKKITLFISNEIGIINDLEDLLNHQELIRTRNYTKRAILNQHHINGHFKDEKKYLKSLYDLRVKFMYGLGSEIVILKFLIEHYKKLNSLRLRLETLNHPLSNYAVYFDILNRIEKQTQLLAKIETLKYDNYDFNADVILDDLESNITKINEIKHNSNVLNKTKVIKTIIEPKYELELISKDDKVDGVKVYVNDQEILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG0</accession>
    <name>Q9PQG0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688467.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU331"/>
    <dbReference type="EnsemblBacteria" id="AAF30740">
        <property type="protein sequence ID" value="AAF30740"/>
        <property type="gene ID" value="UU331"/>
    </dbReference>
    <dbReference type="GeneID" id="29672462"/>
    <dbReference type="KEGG" id="uur:UU331"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.345"/>
    <dbReference type="HOGENOM" id="CLU_2304827_0_0_14"/>
    <dbReference type="OMA" id="NDNFHIY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="100" mass="12119" checksum="16EFD309D2ADEC76" modified="2000-10-01" version="1">MSYYYKSKFRITDHALARFRERAEWTDVNIKNLSGTFIIPIINERILGIRPLNSLDNNFHIYMDPKNKGYYFLVDKYTNTIISYTKRTNKNDFYHIKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG1</accession>
    <name>Q9PQG1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689139.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU330"/>
    <dbReference type="EnsemblBacteria" id="AAF30739">
        <property type="protein sequence ID" value="AAF30739"/>
        <property type="gene ID" value="UU330"/>
    </dbReference>
    <dbReference type="GeneID" id="29672457"/>
    <dbReference type="KEGG" id="uur:UU330"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.343"/>
    <dbReference type="eggNOG" id="ENOG50340U9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917724_0_0_14"/>
    <dbReference type="OMA" id="WHPFAFI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="327" mass="38114" checksum="321275386DAF61B7" modified="2000-10-01" version="1">MNSRFKFNYDINNKLALSFTKDLIANKKQKNKKKFLLFLFPFYPLKLFKTINLIVVFAVLVAIRLGMGFLHIKIPGFNMVISFTWMALMVLGWYFGPLIGIFAGFLVDTLAWLISGGIWFWMYAIQEPIVGFIAGFLGSVATLRKKTKRPIIDLIVNQIFILFFSILTLFMILTLVNDGKNSLFSILKKRDKEINEDWISIFKYLAIAFLATFVLLVEAFVIIYYLRNRNRSKVQLINFIYCSLLVIFSTMLFSFALGPYVSVAYLKYIKVPITNYLKYGVNYYLLPRIIKESIKTPIYIILLSSIISAFDYVFLNIKQINMHKWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG3</accession>
    <name>Q9PQG3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689136.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU328"/>
    <dbReference type="EnsemblBacteria" id="AAF30737">
        <property type="protein sequence ID" value="AAF30737"/>
        <property type="gene ID" value="UU328"/>
    </dbReference>
    <dbReference type="GeneID" id="29672445"/>
    <dbReference type="KEGG" id="uur:UU328"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.341"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911976_0_0_14"/>
    <dbReference type="OMA" id="EILVIYE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="314" mass="37249" checksum="EFEE21645033E285" modified="2000-10-01" version="1">MNLINKELFLITGDNRLKMDQKINEIATSFDELVKINDQEISLISFKNLIEQDDLFNSNKIYLFKNVNWFENLEHLKNVSDLIDYFFNNHVAIIITIESTKISTAKKIQETIAKFNHQITFMTYTNENAMAFLKEELNQRNLSLNKSIMQTIIQKTNFNINFLNNELDKIELINDFLKNHGMFDINNFICDYGEYQIFSLLNLLYQHKINESINLINKMLIDKIDELTIINMLATIMSTHYLIKLLHEKKYNKNVISSSLNQKPYIIDLNLKLIRNYSAKFLLKKMYDLLQLEIKVKENKIDKYFGLINWVLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH7</accession>
    <name>Q9PQH7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lspA</name>
        <name evidence="8" type="ordered locus">UU314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689112.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU314"/>
    <dbReference type="EnsemblBacteria" id="AAF30723">
        <property type="protein sequence ID" value="AAF30723"/>
        <property type="gene ID" value="UU314"/>
    </dbReference>
    <dbReference type="GeneID" id="29672441"/>
    <dbReference type="KEGG" id="uur:UU314"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.327"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155419_0_0_14"/>
    <dbReference type="OMA" id="VREWAIN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="263" mass="30137" checksum="5EB429CE7D617D6E" modified="2000-10-01" version="1">MLQKIKNSNFYIIIKKFNQSLRKINFFEKIILKINNKSIRDYFLSITSLDVIFYKIINFIIVALIVLLSGFLVREWAIDLVVKTKETHHGPIFHFTLNNGIALGRINNHSGIVYTLQSIPIILGFLSFIFLKNSCYYVPLLFLLFGGLGNIIDRSIPEFELFNALPNIFHNSLINPNSVGGGDDVINGVVDYWKFVNSIINLFDVYIVVGVCVLVVILVIRFIIKWKNDSDNQDIIKKVADENDLEINEISNKPFGYDDLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH8</accession>
    <name>Q9PQH8_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD</name>
        <name evidence="5" type="ordered locus">UU313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891730.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU313"/>
    <dbReference type="EnsemblBacteria" id="AAF30722">
        <property type="protein sequence ID" value="AAF30722"/>
        <property type="gene ID" value="UU313"/>
    </dbReference>
    <dbReference type="GeneID" id="29672489"/>
    <dbReference type="KEGG" id="uur:UU313"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.326"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_14"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="299" mass="35389" checksum="B52B22951E4A8C14" modified="2000-10-01" version="1">MKILYSLMSSQRIDKFLVENTNYSRTLIKKMLDQNLILVNDNFISKASYLLKKNDYIQINNELPIVQEQKKLLPFVYSLEIIFEDQDLLIVNKPSGMLVHPTSFHEQNTLANALKYYLKTDNFYITHRLDKNTSGLIIICKNQIALNSLQQQFMQKTIRKSYYAIVHNRFDMQHLHFMINEPIGHSYQDKLRMKTGNSKNTKEAISIVKVLEQYKNTALVEVSIITGRTHQIRVHMRYINHPVYNDPLYGISKHTTEYEQYLHSFYISFNHPSTNKKVEFKINMPKEFMELIRELKANE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI7</accession>
    <name>GREA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">greA</name>
        <name type="ordered locus">UU304</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688739.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQI7"/>
    <dbReference type="SMR" id="Q9PQI7"/>
    <dbReference type="STRING" id="273119.UU304"/>
    <dbReference type="EnsemblBacteria" id="AAF30713">
        <property type="protein sequence ID" value="AAF30713"/>
        <property type="gene ID" value="UU304"/>
    </dbReference>
    <dbReference type="GeneID" id="29672476"/>
    <dbReference type="KEGG" id="uur:UU304"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_1_14"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000176988" description="Transcription elongation factor GreA">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <sequence length="156" mass="17767" checksum="86BEA8EC07C96461" modified="2000-10-01" version="1">MAKYTISKHRLEELQLELREILDVKWPAITKQLQDAREQGDLSENADYDAAKNEQAALKKRKDEIEEILENYELIEDVLRSTDEVSIGSTIEIYNYQKDCEEVITLVGSMDSDPFANKISIDTPLGKALVKQKKGTEVTVHTLASPYKVKIIKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ0</accession>
    <name>Q9PQJ0_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="7">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">UU301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="7"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688937.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU301"/>
    <dbReference type="EnsemblBacteria" id="AAF30710">
        <property type="protein sequence ID" value="AAF30710"/>
        <property type="gene ID" value="UU301"/>
    </dbReference>
    <dbReference type="GeneID" id="29672449"/>
    <dbReference type="KEGG" id="uur:UU301"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.313"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_3_0_14"/>
    <dbReference type="OMA" id="IGPEGCF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="234" mass="27460" checksum="F09DF93F1F8FE8ED" modified="2000-10-01" version="1">MQRYFVSKIKDKKVYFYDSDVHHIKNVMRMRLHDKVIVINKTKAFVAEIINLEPLHATIIKPYTLNCELATKIDLFQASIKPNNFEWIVQKACELGVNSIYQTIFKRTYNHSLIKTNRILTIIKEACEQARRNHLVNYYAQFSFNELLKYLRDYDLILIAYENEKQNLLNNAFKEELTYQKIALVIGPEGGFEQMEINLLKQFDNAICISLTKTILRSETASLYLLANLVNKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ2</accession>
    <name>Q9PQJ2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688898.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU299"/>
    <dbReference type="EnsemblBacteria" id="AAF30708">
        <property type="protein sequence ID" value="AAF30708"/>
        <property type="gene ID" value="UU299"/>
    </dbReference>
    <dbReference type="GeneID" id="29672521"/>
    <dbReference type="KEGG" id="uur:UU299"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.311"/>
    <dbReference type="HOGENOM" id="CLU_2304825_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="100" mass="11469" checksum="493C83CB4FDBB367" modified="2000-10-01" version="1">MQYITINNTKSGKILISKSNIKKFIEQKFNLIVNKKFVIKNIDIVQYDESLVDISIIISLFDIHQKVDLDEVRDVQNHLASFIYSNLGVDTKSVNIGIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ5</accession>
    <name>Q9PQJ5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU296"/>
    <dbReference type="EnsemblBacteria" id="AAF30705">
        <property type="protein sequence ID" value="AAF30705"/>
        <property type="gene ID" value="UU296"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU296"/>
    <dbReference type="HOGENOM" id="CLU_1179798_0_0_14"/>
    <dbReference type="OMA" id="NNYHDFE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="246" mass="29573" checksum="B2FC36BBE738B9D2" modified="2000-10-01" version="1">MSNYELRRRIIMSNIDVKTNFWKLNQKNKKILFRVLGYSSLSVTIITPLIYKISYNKQYSFITKSIRELKTIDTNFVSSYSDFYILQKSSISNDLYNYNLINNYHDFEKLIKNDLNFDKYNSALIYEKIKVSLLEKYNENFFKNNDLLYVSYNSLDSKYFLTSILSFDYNNLYLPFLNTKSIFNDEYDNKNFYTDSALSTTKTEVKFFSINKKYNIKLKQIKIYSIETAKDLFLYKNYVRKNNKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ8</accession>
    <name>Q9PQJ8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU293"/>
    <dbReference type="EnsemblBacteria" id="AAF30702">
        <property type="protein sequence ID" value="AAF30702"/>
        <property type="gene ID" value="UU293"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU293"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251516_0_0_14"/>
    <dbReference type="OMA" id="SELNIYM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1447" mass="167446" checksum="A22A194FF79A0289" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK0</accession>
    <name>Q9PQK0_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bsaA</name>
        <name evidence="6" type="ordered locus">UU291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU291"/>
    <dbReference type="EnsemblBacteria" id="AAF30700">
        <property type="protein sequence ID" value="AAF30700"/>
        <property type="gene ID" value="UU291"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU291"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_3_2_14"/>
    <dbReference type="OMA" id="FPMMSKI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="162" mass="19305" checksum="193E63A8E07E5F7A" modified="2000-10-01" version="1">MERLNMKLSDYPVLDIDKKLFNWSKVKNKLVLIVNVASKCGYAKQYEQLEYLYKKYKNKGFIIVAFPCRQFMFQEFDDNNKIKEFCSTKYNVTFPIMDLTNVVGSNISPLYKQLITEYPWSPKAKAVKWNFEKFFVKNDEIIGRFESKCEPNDLEEFIKNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-06-17" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK4</accession>
    <name>Q9PQK4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU287"/>
    <dbReference type="EnsemblBacteria" id="AAF30696">
        <property type="protein sequence ID" value="AAF30696"/>
        <property type="gene ID" value="UU287"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU287"/>
    <dbReference type="HOGENOM" id="CLU_087305_0_0_14"/>
    <dbReference type="OMA" id="VWNDLYD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="201" mass="23873" checksum="FD0012911C4BD7E8" modified="2000-10-01" version="1">MINKKIKINPNITYFKQKISNYHEHLLVWNDLYDKLISLTNNIIVDKNNKNIYHQNDKQIFDFTLCLSGLLSKTLGLNHKSSSLYLTNDDEVAHRFKIKVLHNYFNLYNIEEFFTFMDNQIPLENAKNIARLSLIYDLKQHENILKTISNEGLENIDLEFAFINFLRAKISINFAYSYDISEVILLLRTGLDLHFFRKWAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL2</accession>
    <name>PGK_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoglycerate kinase</fullName>
            <ecNumber>2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pgk</name>
        <name type="ordered locus">UU279</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688945.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQL2"/>
    <dbReference type="SMR" id="Q9PQL2"/>
    <dbReference type="STRING" id="273119.UU279"/>
    <dbReference type="EnsemblBacteria" id="AAF30688">
        <property type="protein sequence ID" value="AAF30688"/>
        <property type="gene ID" value="UU279"/>
    </dbReference>
    <dbReference type="GeneID" id="29672564"/>
    <dbReference type="KEGG" id="uur:UU279"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_1_14"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000146033" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="422" mass="47383" checksum="F3F45A1542A3783C" modified="2000-10-01" version="1">MNSLNKKSIKDLDVNGKTIVLHLDLNVVVDYENKRILNDRKLRASLPTINYLINHNAKIVILSHLGRIKTLADKQSGKYSLEIIVDELRNRVSKNVNRVVFSPLNYGETVVQMVNDLEERDILILENTRYCDISDEGEYVGLEWDGSEILGQFWGMLGDIFIDDAYGVAHRQLSSNYQTAKFAKKSALGFLIVNEINHLDIALEVPKSPYLALIGGNRVADKIAAIEVLCERADQVIIGGGLVYTFLYAQGYNVGLNLVERNMIDDCNNILEKYGKKILICFDFLCNNDFSDTRPIYRKIDEGLEGLYGLDIGKRSLKFIKHEIYRSKTILLNGPFGVIENIKNYAQGTTEICKSMAKQTTRGAYTIICDIDTSSHAEYLGLDKYINFISTGGGASLSYIEEGVLDGLETIDNVPLNVLKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL8</accession>
    <name>Q9PQL8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688961.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU273"/>
    <dbReference type="EnsemblBacteria" id="AAF30682">
        <property type="protein sequence ID" value="AAF30682"/>
        <property type="gene ID" value="UU273"/>
    </dbReference>
    <dbReference type="GeneID" id="29672556"/>
    <dbReference type="KEGG" id="uur:UU273"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.282"/>
    <dbReference type="HOGENOM" id="CLU_1111019_0_0_14"/>
    <dbReference type="OMA" id="YIEMIRF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="251" mass="30213" checksum="2B8DDF543189F3C9" modified="2000-10-01" version="1">MEQIRNLIDLQIKLKPIQKAFYDAWSKTFINGIDNNKETHEQNKKIILEIYMILKVFLNKNRDIISKIPLNQVKKIANDILEKEIILEQPLVDYYYQSSSCFILIPYLIQILYQSYHLNKPIYKIMCKFIIRNNLALFKEWDLIERQTLEIIKLKTNLIEDNNKAINLFSCEQRELQHNRFVKLFNNFILVYWTKREVKYIEAIRFLMYFIWIPIIFIVLLILILGLYFGLSNSESLKSSTQFLLDLFIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN1</accession>
    <name>Q9PQN1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689323.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU260"/>
    <dbReference type="EnsemblBacteria" id="AAF30669">
        <property type="protein sequence ID" value="AAF30669"/>
        <property type="gene ID" value="UU260"/>
    </dbReference>
    <dbReference type="GeneID" id="29672527"/>
    <dbReference type="KEGG" id="uur:UU260"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.269"/>
    <dbReference type="eggNOG" id="ENOG50349EE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636068_0_0_14"/>
    <dbReference type="OMA" id="EAYKKNW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027593">
        <property type="entry name" value="Aro_clust"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04313">
        <property type="entry name" value="aro_clust_Mycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="431" mass="50665" checksum="58C97B00D95C1922" modified="2000-10-01" version="1">MFIFFKKNHLLKLSLFFIPLTLISILITSCSTSNLKKQQILTNNEISFFMDKSQNCYVGLIVDQTLKNDKKTIFNVSLIDEKNTKLNLLVKDYQIKDNKILIRLPRLIKLNDHLIITSNNASFIPIRKIINIDNLIDLNIIRTNNQTQDSWIAFLNNKVINNLLITIFPNKKDRDEYIKSQQEIKIEYAHEIANWLNYYNTVQNDANKAAVFNENTARSKLNNNLFNNVSLSNPFAYEQARKFHNTLFNKNWLWFLFNLKRQIFMLYPDDNLFQESSEETAEGLKDSKINNRSSFYRAQSNEFIDGLYVVESSNLNKKPEELDEYTDFSKTAKFTLLNNEGFVFTISIEENYDKTKKLISRKVSLLPWIKTLPRLMFNDHVIKQEFNLANYTENSYDYNAVNFHSPLEIKVYEDQFGGKAIRFSFVDIDPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP9</accession>
    <name>RL24_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name evidence="1" type="synonym">rpl24</name>
        <name type="ordered locus">UU242</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688875.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQP9"/>
    <dbReference type="SMR" id="Q9PQP9"/>
    <dbReference type="STRING" id="273119.UU242"/>
    <dbReference type="EnsemblBacteria" id="AAF30651">
        <property type="protein sequence ID" value="AAF30651"/>
        <property type="gene ID" value="UU242"/>
    </dbReference>
    <dbReference type="GeneID" id="29672578"/>
    <dbReference type="KEGG" id="uur:UU242"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_3_14"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130747" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="110" mass="12267" checksum="77BAE1FF7994FA60" modified="2000-10-01" version="1">MNRIKKGDTVVVISGKNKNKSGVVIQVNPKEQTALVEGVNKIKRHQKKDQTHEQSGIIEKEAPIRLCKLALVDPKGKDKGKATKVKYLLKDNKKVRVARKSGSELDVNKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ8</accession>
    <name>RL23_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">UU233</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689129.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ8"/>
    <dbReference type="SMR" id="Q9PQQ8"/>
    <dbReference type="STRING" id="273119.UU233"/>
    <dbReference type="EnsemblBacteria" id="AAF30642">
        <property type="protein sequence ID" value="AAF30642"/>
        <property type="gene ID" value="UU233"/>
    </dbReference>
    <dbReference type="GeneID" id="29672689"/>
    <dbReference type="KEGG" id="uur:UU233"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_2_0_14"/>
    <dbReference type="OMA" id="AIAFESM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000144621" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="105" mass="11950" checksum="811D54AFCB7B26DE" modified="2000-10-01" version="1">MELTRVILHPYTTEKTYSIRNKSEHETLTFIVDKNANKYQIREAFIAIFGLKPLKIRTTNRRPAKIRTSTARPGYTKAKKIAYVVMPVGVKVAVSKEEVEAANAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS4</accession>
    <name>Q9PQS4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">amt-1</name>
        <name evidence="10" type="ordered locus">UU218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU218"/>
    <dbReference type="EnsemblBacteria" id="AAF30626">
        <property type="protein sequence ID" value="AAF30626"/>
        <property type="gene ID" value="UU218"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU218"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_14"/>
    <dbReference type="OMA" id="IWLSIMS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="51"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAF30626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="510" mass="54730" checksum="2384FA7FD4250393" modified="2000-10-01" version="1">MRIVSTIITTSWGVDPNIYFSKHELTWVPATADANTLALTNFNPTSTLLVALAIAFVLLMTPGLALFYGGLTRRKSTLTIINQCVASLGITTLIWIFGGFSLAFGPSVGKGIIGDISTYFAFRNLLFADGWSGDVGIVFANFTNGVPLILFFAYQLAFAIITPPLMVGAFADRMKFKNYLVFLVLWQYLIYIPFAHWIWGQGFLAAAGVIDFAGGIVIHTTAGFGALAASLVLGKRVLLKNDKSRPHNIPMTIIGATLLFFGWFGFNVGGSGFVAGGNAATWSAATSAWINTIIALAIGMVGWAVLETIFNKNHKATGVGLVTGAIAGLATITPAAGYVPIWASVPIGVAAVLVCYTSAKTLHHFHKIDDTLEVWGVHGMGGVTGSLLIGAFASKSVNPSIMYEAIGPTTTGVLFGVQLGAVLLAAVYGFVFTILLVYITRPRLSARQQLGHIDYINHGEDAYSFDIEIPSEKEMEQYELADSTWHSSTGVKYSLLNNKNQQNHKVANDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS6</accession>
    <name>Q9PQS6_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pkn</name>
        <name evidence="6" type="ordered locus">UU216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688905.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU216"/>
    <dbReference type="EnsemblBacteria" id="AAF30624">
        <property type="protein sequence ID" value="AAF30624"/>
        <property type="gene ID" value="UU216"/>
    </dbReference>
    <dbReference type="GeneID" id="29672658"/>
    <dbReference type="KEGG" id="uur:UU216"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.224"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700090_0_0_14"/>
    <dbReference type="OMA" id="LAMEWIQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="386" mass="45242" checksum="789374CC15D1CAD9" modified="2000-10-01" version="1">MREEIKTNSILNYKYKVVKHLADGGFSKVYLCCFLSDETKFIVIKVLDINDEKQQMVVYDELRISNLIKNSDSDKKNYIMEYYEYFETGSLENNDKRIYIVFEYIEGLTLREYLDEFKTITYVKAVEIIRQVALGVSFFHSCNPQIIHRDLKPENCMINKTLTKIKIIDYGAASVFYNREDLTKDQEIKCTIIYASPKLLSLGQKVKEQANKGLNKRALSLINDALGVSYDIHSLGVMLYELITGTNPFSEHTITDDRDYLEKWITYDVEPLSLINKTIPKGIDNILMRCFAWKKEDNKLLYKDIYTLIDDLSNVMDPESNLNQEYIKPLNKLRIYRKNLAGLYEIKEKDRKWYLQKWFIILISCLSVILIILLIIILFFKKSGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU0</accession>
    <name>Q9PQU0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper-transporting P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">copA</name>
        <name evidence="7" type="ordered locus">UU203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688858.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU203"/>
    <dbReference type="EnsemblBacteria" id="AAF30610">
        <property type="protein sequence ID" value="AAF30610"/>
        <property type="gene ID" value="UU203"/>
    </dbReference>
    <dbReference type="GeneID" id="29672661"/>
    <dbReference type="KEGG" id="uur:UU203"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.210"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_11_2_14"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="709" mass="79245" checksum="AFEAFB66B0E0E982" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU2</accession>
    <name>Q9PQU2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688962.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU201"/>
    <dbReference type="EnsemblBacteria" id="AAF30608">
        <property type="protein sequence ID" value="AAF30608"/>
        <property type="gene ID" value="UU201"/>
    </dbReference>
    <dbReference type="GeneID" id="29672715"/>
    <dbReference type="KEGG" id="uur:UU201"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.208"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107119_0_0_14"/>
    <dbReference type="OMA" id="STWIISK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoU" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="218" mass="26096" checksum="8A2C511C7CB460D9" modified="2000-10-01" version="1">MATNYFLMKESQCDLLNDFKNFFQMVIDNQKLICDLLKNDQSSYKETYEKACFLEKKVNTTYADMLEEIMWIIQRDQPRASYLRFFIAGINSIKDLERISDHSEIICEYFLETEFDEEQKNFFLTSFEISNQILSDLYDFFDKNEFSVNTIEHIKDLRSKSIMKINKNLIQSLHDQSKLLDENSNYIKLILMYRHIERNIEHGINIVQNFGNVHITSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV2</accession>
    <name>Q9PQV2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU191"/>
    <dbReference type="EnsemblBacteria" id="AAF30598">
        <property type="protein sequence ID" value="AAF30598"/>
        <property type="gene ID" value="UU191"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU191"/>
    <dbReference type="HOGENOM" id="CLU_3206641_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="45" mass="5479" checksum="5F255F312DCD11E9" modified="2000-10-01" version="1">MKTAILIDTGANVLDIKDDNVYFVPIQLIIREQQIWKRIKRCYWR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-02-28" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV3</accession>
    <name>Y190_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>DegV domain-containing protein UU190</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU190</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQV3"/>
    <dbReference type="SMR" id="Q9PQV3"/>
    <dbReference type="STRING" id="273119.UU190"/>
    <dbReference type="EnsemblBacteria" id="AAF30597">
        <property type="protein sequence ID" value="AAF30597"/>
        <property type="gene ID" value="UU190"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU190"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.197"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_5_0_14"/>
    <dbReference type="OMA" id="WASELRY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000209819" description="DegV domain-containing protein UU190">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DegV" evidence="3">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>hexadecanoate</name>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9X1H9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00815"/>
        </source>
    </evidence>
    <sequence length="216" mass="24513" checksum="849C5909A46629E6" modified="2000-10-01" version="1">MLWKNLDELFLKYDRVVILTLSSGLSSYFESLSIIKEDYKDKHLVCIDSRSVSIGILWLVDEINLLLKNNPSDEELISLVKQRSQKIIGGVIVNNLDQLIAGGRVKKTKGIIAKALRLKLIVRWNGQLDFMDKTPNLSTAIDKLLDIIDNQNHWRTNGIKNIAILTDLENESQINSLKTSLQEKIRQTIEIKISYLPGCIYAHVGLNNFAILIEAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV9</accession>
    <name>ENO_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno</name>
        <name type="ordered locus">UU184</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688966.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQV9"/>
    <dbReference type="SMR" id="Q9PQV9"/>
    <dbReference type="STRING" id="273119.UU184"/>
    <dbReference type="EnsemblBacteria" id="AAF30591">
        <property type="protein sequence ID" value="AAF30591"/>
        <property type="gene ID" value="UU184"/>
    </dbReference>
    <dbReference type="GeneID" id="29672638"/>
    <dbReference type="KEGG" id="uur:UU184"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_14"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000134002" description="Enolase">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="378"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="440" mass="49301" checksum="5F32F530B7A2B7FA" modified="2000-10-01" version="1">MKIINLLAYQILDSRGQPTVAVKLFLENDQSVIAMVPSGASTGAKEALELRDGDVNYFFNKSVKLAIQNINNIIRPHLINKNVLNFFELDNLLINLDGTENKSKLGANALLGVSIAIVKAGAIAASKPLYQYIKEDLMHNYDVNYYAPIPLMNFINGGAHADNDLDIQEFMIVPLNAISFSQAIQIGSEIFHQLDKLLKSNHLSTTKGDEGGFAPMLKNNYVTLELLVHAIKKAHYLPSKTQGVCLALDVAASELYENGKYFFKKSSSHNITLEQTSFSSDEWIKYWSKLVSMFPIISIEDCFEENDWNSFALFLKNNPHIQVVGDDLYCTNLKYLQKGIDFKATNAILIKPNQIGTISETLDVIKFAQKNNINTIISHRSGETEDTFIADLAIGVGAGQIKTGSLSRSERIAKYNRILEIEQELKDKLIYEPSKFFKFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW4</accession>
    <name>Y179_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU179</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU179</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891702.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW4"/>
    <dbReference type="STRING" id="273119.UU179"/>
    <dbReference type="EnsemblBacteria" id="AAF30586">
        <property type="protein sequence ID" value="AAF30586"/>
        <property type="gene ID" value="UU179"/>
    </dbReference>
    <dbReference type="GeneID" id="29672618"/>
    <dbReference type="KEGG" id="uur:UU179"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.186"/>
    <dbReference type="HOGENOM" id="CLU_2738904_0_0_14"/>
    <dbReference type="OMA" id="YQDEKEI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220829" description="Uncharacterized protein UU179">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <sequence length="73" mass="8617" checksum="39FC68FF623D16FC" modified="2000-10-01" version="1">MLIKPAKRSEKIYTIIAIKDSVVTLKNDYQDEKNIQIYEFDLQNIIPEVGKFINLIKYDQQGCSVFEEYDKNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW6</accession>
    <name>NADK_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD kinase</fullName>
            <ecNumber evidence="1">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadK</name>
        <name type="ordered locus">UU177</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688904.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW6"/>
    <dbReference type="SMR" id="Q9PQW6"/>
    <dbReference type="STRING" id="273119.UU177"/>
    <dbReference type="EnsemblBacteria" id="AAF30584">
        <property type="protein sequence ID" value="AAF30584"/>
        <property type="gene ID" value="UU177"/>
    </dbReference>
    <dbReference type="GeneID" id="29672697"/>
    <dbReference type="KEGG" id="uur:UU177"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_3_14"/>
    <dbReference type="OMA" id="KDNSFWE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000120685" description="NAD kinase">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <sequence length="270" mass="31358" checksum="E130EBA81798C731" modified="2000-10-01" version="1">MKNNKPICFYDIYCFKPQECFKRNDINLLEDKLKRYSKITFLRNKENPEIIFLLGGDGSFINFINQQWKKNVKIVGINYGQLGFYSSYDSIKTINLDEIIDENMYYNPLLLKVSINNQNFFYCLNELSLFSNELVSFDISINDYPYEKFRGSGLLFVTPSGSTGKNKTAFGPIIFNNHENFIMTEIFPVNHLKYSSLNAPVVFRKDYKISLTNIKFKKSFSVAIDGNIINFSDKINDIKVETIQASSKIHGLNNFKKYIDKLNKSFIKGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW7</accession>
    <name>Y176_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU176</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU176</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688944.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW7"/>
    <dbReference type="SMR" id="Q9PQW7"/>
    <dbReference type="STRING" id="273119.UU176"/>
    <dbReference type="EnsemblBacteria" id="AAF30583">
        <property type="protein sequence ID" value="AAF30583"/>
        <property type="gene ID" value="UU176"/>
    </dbReference>
    <dbReference type="GeneID" id="29672709"/>
    <dbReference type="KEGG" id="uur:UU176"/>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116644_1_1_14"/>
    <dbReference type="OMA" id="IMIDDKR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000162588" description="Uncharacterized protein UU176">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="128" mass="15033" checksum="E55A61E381CF70E1" modified="2000-10-01" version="1">MIYVLYSPNCAVCKKVVRFFRNNQIEITKIIIGEDKIERSMLLDILSLCEDGFGTIISFKTESSKRLNITSKTFLDLSTKELLNLIQNDLNLIRRPLIYQTKNNRPYRLQIGYDSEEIEIFKRAVHEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-08" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW8</accession>
    <name>SYW_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="1">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpS</name>
        <name type="ordered locus">UU175</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688883.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW8"/>
    <dbReference type="SMR" id="Q9PQW8"/>
    <dbReference type="STRING" id="273119.UU175"/>
    <dbReference type="EnsemblBacteria" id="AAF30582">
        <property type="protein sequence ID" value="AAF30582"/>
        <property type="gene ID" value="UU175"/>
    </dbReference>
    <dbReference type="GeneID" id="29672759"/>
    <dbReference type="KEGG" id="uur:UU175"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_1_14"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136704" description="Tryptophan--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <sequence length="333" mass="37755" checksum="AE6646EB161797FF" modified="2000-10-01" version="1">MKRLISGIQPTNNLTLGNYLGAIKNFVDLQDDYEVFLFVADLHSLTPNIFDNTDFSTTKRQIIATYLAAGIDPKKTCLFYQSDILSIPLLAHILLCSTSIGELTRMTQFKDKSIKATKMANNTEMIPSGLLTYPTLMAADILTFNADVVPVGQDQKQHLELTRTLADRFNKRYGNTFKLPQVYIPKIGAKIMDLLDPNIKMSKSSKNLKGVIFLNDSKDIIFKKIKGALTDNLNKVKYDLTLQPGVSNLMTIYACLTNLSFKEIELKYQQQNYGVFKNDLANIVADFLEKLQQKISYWLNSPELDIMIDNSCERANDIAYQNVQLVLKHMQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW9</accession>
    <name>Q9PQW9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688955.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU174"/>
    <dbReference type="EnsemblBacteria" id="AAF30581">
        <property type="protein sequence ID" value="AAF30581"/>
        <property type="gene ID" value="UU174"/>
    </dbReference>
    <dbReference type="GeneID" id="29672703"/>
    <dbReference type="KEGG" id="uur:UU174"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.181"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_1_1_14"/>
    <dbReference type="OMA" id="APHNNEE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="291" mass="32780" checksum="48CA767FCDFCAEA4" modified="2000-10-01" version="1">MGKNNKYLIACDLDGTLLNNDSDISEKTIEGIKKIINQGHIFCIVTGRPLRGSIHIYEKLGLTTLMANYNGSYISNPSDKKFAPINMTFSKDIVSAILKNRFIAKNIVNAVVEADNVATILNSNMDLNIWKSFIDIFHVPIRDMNEKNKLTKENDINNLIRDANALLLNVNDKALFDSMVYHIKQIAPTLAVRSWSARVDDQFEVIEINSSFADKAMAMRYLSSYYGIPLDRCIAFGDGENDLTMLNHAGYGFAMKNGTRPAKLLARHITKHTNVENGVVWELEYVLNENK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX6</accession>
    <name>Y167_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU167</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU167</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQX6"/>
    <dbReference type="SMR" id="Q9PQX6"/>
    <dbReference type="STRING" id="273119.UU167"/>
    <dbReference type="EnsemblBacteria" id="AAF30574">
        <property type="protein sequence ID" value="AAF30574"/>
        <property type="gene ID" value="UU167"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU167"/>
    <dbReference type="HOGENOM" id="CLU_2060446_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220825" description="Uncharacterized protein UU167">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <sequence length="119" mass="14280" checksum="F58A475ED92C8BF9" modified="2000-10-01" version="1">MKVELYTNDWIDFFKNIAIAWFKTKRYGNKRLSSIEQKQVNKLIRQEFDQYVEFKIISNLIKDYNDNMEKVISLYGANLMPLNLAVQKLYPELTPTEQDELVKELEHKQKLENGEFENE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY0</accession>
    <name>Y164_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU164</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU164</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025528.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQY0"/>
    <dbReference type="STRING" id="273119.UU164"/>
    <dbReference type="EnsemblBacteria" id="AAF30570">
        <property type="protein sequence ID" value="AAF30570"/>
        <property type="gene ID" value="UU164"/>
    </dbReference>
    <dbReference type="GeneID" id="45015937"/>
    <dbReference type="KEGG" id="uur:UU164"/>
    <dbReference type="HOGENOM" id="CLU_698175_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220821" description="Uncharacterized protein UU164">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <sequence length="395" mass="45004" checksum="A3153D06914E4FFA" modified="2000-10-01" version="1">MADNQNTWKRPDPNAKYTITQYLDVVNANNERVVAGGFEKYMLENQFNAEFLGSATMTPTKIMDDMRTAIYEVGVIGQVEEYRDDFTQKQVPAIDRLTLHLSNDYQKEVSISVFDKKTGAQWNDFLAKTLANLEVVKQDQINLINIDAIYQSCLATGNYIIIPELSPDRVESLTDDERLKIVEKIYRKAKQVTKSRTKFNLGADPNKLRFVLSDDAALVVLTAKTYKIRDGQAYSDYSTKGLGSSSQYMGDYLGMPIYSSAYLGEDYLKSTDQKYTSNLIRDYKFSKLSGIITMPETTICLKQELMLTTFQSPTSKSHQLIHNSWSMNSAVFPQFAHLNFVILNDKPTKDEINKARSNLYSQFPSLYAEFKTPISEDSKITEVNKANWRGLSTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY1</accession>
    <name>Q9PQY1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU163"/>
    <dbReference type="EnsemblBacteria" id="AAF30569">
        <property type="protein sequence ID" value="AAF30569"/>
        <property type="gene ID" value="UU163"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU163"/>
    <dbReference type="HOGENOM" id="CLU_1229472_0_0_14"/>
    <dbReference type="OMA" id="RNPLARY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="260" mass="30694" checksum="F785A59F7A47EF67" modified="2000-10-01" version="1">MGILILILRFVGRLLLSKIKSLISTLINLFSRMLKMFKFDFFKMFKNKTGAFMKKGKTVFHDFNLKPDDILKKFFDNSSLEKIFNSKELKIIQDNKDLAKKLKDAINEAIKDIAKQTSKYTTKQKDSIIKHLTDTLDNASKTEKKNFEKVRKENQFKDVDNVDIDFNKHWIDYGTWYASDGVGKIGYLTLKLMKPSKRNPLARYTWRNIPKRIATMLKFAPTGTTFWNIFYHANRKNLIHLQKESIYWFDASRKYFEGVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY5</accession>
    <name>Y159_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU159</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU159</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891692.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQY5"/>
    <dbReference type="SMR" id="Q9PQY5"/>
    <dbReference type="STRING" id="273119.UU159"/>
    <dbReference type="EnsemblBacteria" id="AAF30565">
        <property type="protein sequence ID" value="AAF30565"/>
        <property type="gene ID" value="UU159"/>
    </dbReference>
    <dbReference type="GeneID" id="29672762"/>
    <dbReference type="KEGG" id="uur:UU159"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.165"/>
    <dbReference type="HOGENOM" id="CLU_1481371_0_0_14"/>
    <dbReference type="OMA" id="WRTVAKM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220818" description="Uncharacterized protein UU159">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="182" mass="21498" checksum="2524C855E8D50FEB" modified="2000-10-01" version="1">MMNNKNKFKNKEWKFSKKQVQLIYLTSSIISGLFLGLALLSTYLIAGLPNDNAFVLFVKEQKFYFPFFMTIGFINLIISMLTLLPTLKTLWRTVAKMHQYGDLSKEEFEALDILVEQIRNRYISVENIKAVISSNNYKTLDEELKKLEQQEKQLKIQEQEQKVKRLEQEIIKDDKTRVQSDY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ0</accession>
    <name>Y154_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU154</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU154</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025556.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ0"/>
    <dbReference type="STRING" id="273119.UU154"/>
    <dbReference type="PRIDE" id="Q9PQZ0"/>
    <dbReference type="EnsemblBacteria" id="AAF30560">
        <property type="protein sequence ID" value="AAF30560"/>
        <property type="gene ID" value="UU154"/>
    </dbReference>
    <dbReference type="GeneID" id="45015946"/>
    <dbReference type="KEGG" id="uur:UU154"/>
    <dbReference type="HOGENOM" id="CLU_1266438_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010183">
        <property type="entry name" value="Phage_lambda_Bet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018330">
        <property type="entry name" value="RecT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03837">
        <property type="entry name" value="RecT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01913">
        <property type="entry name" value="bet_lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220813" description="Uncharacterized protein UU154">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <sequence length="218" mass="24471" checksum="16D39E5284BE12A0" modified="2000-10-01" version="1">MVKDDKLVPSIRLLTPNELSEQWANPNSEINQITRAVLTIQGIDLKAIDLNQAAQIIYFCQANNLNPLNKEVYLIQMGNRLAPIVGIHTMTERAYRTERLVGIVQSYNDVNKSAKTILTIRSPGLKGLGTVEAEVFLSEYSTNKNLWLTKPITMLKKVSLAHALRLSGLLAFKGDTPYIYEEMQQGEAVPNKKMFTPPVAEVIEPAVENIKKVDFNEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ1</accession>
    <name>Y153_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU153</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU153</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026070.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ1"/>
    <dbReference type="SMR" id="Q9PQZ1"/>
    <dbReference type="STRING" id="273119.UU153"/>
    <dbReference type="EnsemblBacteria" id="AAF30559">
        <property type="protein sequence ID" value="AAF30559"/>
        <property type="gene ID" value="UU153"/>
    </dbReference>
    <dbReference type="GeneID" id="45015947"/>
    <dbReference type="KEGG" id="uur:UU153"/>
    <dbReference type="HOGENOM" id="CLU_2157279_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220812" description="Uncharacterized protein UU153">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <sequence length="111" mass="12842" checksum="6C46B539BB3940CE" modified="2000-10-01" version="1">MTNSIKREILSALNDETKKVISKLQQTNNLIKQLSDEKKTLEQYLKDNVNNHEIVDLDSDLKIKIYDLTSKDSIVLDYDKIITDYKVDTKKYETIKKGTTSTRITWSGADK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-11-02" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR08</accession>
    <name>ATPL_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">F-type ATPase subunit c</fullName>
            <shortName evidence="2">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atpE</name>
        <name type="ordered locus">UU136</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Dicyclohexylcarbodiimide (DCDD) binding to the active glutamate residue inhibits ATPase in vitro.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688882.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR08"/>
    <dbReference type="SMR" id="Q9PR08"/>
    <dbReference type="STRING" id="273119.UU136"/>
    <dbReference type="EnsemblBacteria" id="AAF30542">
        <property type="protein sequence ID" value="AAF30542"/>
        <property type="gene ID" value="UU136"/>
    </dbReference>
    <dbReference type="GeneID" id="29672138"/>
    <dbReference type="KEGG" id="uur:UU136"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2182821_0_0_14"/>
    <dbReference type="OMA" id="ALIFRQY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000112175" description="ATP synthase subunit c">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <sequence length="109" mass="11018" checksum="CD72373089564AD3" modified="2000-10-01" version="1">MSSFIDITNVISSHIEANLPAIASENVGSLANGAGIAYLGKYIGTGITMLAAGAVGLMQGFSTANAVQAVARNPEAQPKILSTMIVGLALAEAVAIYALIVSILIIFVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-29" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR28</accession>
    <name>UPP_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">upp</name>
        <name type="ordered locus">UU116</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688866.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR28"/>
    <dbReference type="SMR" id="Q9PR28"/>
    <dbReference type="STRING" id="273119.UU116"/>
    <dbReference type="EnsemblBacteria" id="AAF30522">
        <property type="protein sequence ID" value="AAF30522"/>
        <property type="gene ID" value="UU116"/>
    </dbReference>
    <dbReference type="GeneID" id="29672761"/>
    <dbReference type="KEGG" id="uur:UU116"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_14"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000120908" description="Uracil phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <sequence length="207" mass="23035" checksum="E940FD64D5B0C347" modified="2000-10-01" version="1">MHKIINHPLIKDKLTRMRKVSTVSTVFRTNLEELTQLMVYEATKDLELNEIEIETPVVKVAKGYKLKNKICLIPILRAGIGMVDGVKSLIPTATIGHIGLYRNEQTLKPVEYFKKFPKNISESDVIILDPMLATGGSVVEAVNIIKKYNPKSIKFVCIVAAPEGLKYVQEVHPEVDVYIAALDDKLNENGYITPGLGDAGDRIFGTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-29" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR30</accession>
    <name>DYR_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Dihydrofolate reductase</fullName>
            <ecNumber>1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">folA</name>
        <name type="ordered locus">UU114</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689146.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR30"/>
    <dbReference type="SMR" id="Q9PR30"/>
    <dbReference type="STRING" id="273119.UU114"/>
    <dbReference type="EnsemblBacteria" id="AAF30520">
        <property type="protein sequence ID" value="AAF30520"/>
        <property type="gene ID" value="UU114"/>
    </dbReference>
    <dbReference type="GeneID" id="29672261"/>
    <dbReference type="KEGG" id="uur:UU114"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_5_2_14"/>
    <dbReference type="OMA" id="EECFVIG"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000186419" description="Dihydrofolate reductase">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DHFR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="156" mass="18534" checksum="93A79ED2E62282AC" modified="2000-10-01" version="1">MLKLIWCQTLNGGISKNNKLPWYIKEELDHFYKTTKNHKIIMGKNTFDSLDQKPLNNRTNIIFSSIMQTPEDESYFVTNDFQQVLNDAKKEDIFIIGGKELFDIFLAYADVLIVSVLKDYYDCDLYMKVDYNNFNLDKQDVYDNFIVNYYSNKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR36</accession>
    <name>Q9PR36_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">potB</name>
        <name evidence="6" type="ordered locus">UU108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688430.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU108"/>
    <dbReference type="EnsemblBacteria" id="AAF30514">
        <property type="protein sequence ID" value="AAF30514"/>
        <property type="gene ID" value="UU108"/>
    </dbReference>
    <dbReference type="GeneID" id="29672256"/>
    <dbReference type="KEGG" id="uur:UU108"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.114"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_18_8_14"/>
    <dbReference type="OMA" id="YPIAYGM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="109"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="335" mass="37445" checksum="4A856098BB023229" modified="2000-10-01" version="1">MNKQFNFNFAPSKLSDINKKNETVFFLKEVKVIKKNNRKHYKQTLFDKLKMNKALILTIPYFLVTIFLLIIPLVSIIVKTFINNTDSTGVTTNIIDNWSVITPTIGMKIFNSLWIAAVATIFCLIIGYPFAYFLSIGKSKFLKAIAIALITSPIWMSMLVKLIGIKTFFDVVNGEINSTHGHIFTILGLVYINLPLMILPIYTSLSTMPKNLVNASYDLGRGFFYTFFHIVIPYTKNALISGVWIVYLAAFTSVVVSGFLNNDNAGGLIGGEIFAQGQDGISSGVQLSRSSTITLVISLILLGIYLIIVIIPKIVQLIYYKRKNLKKGVKNNEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR39</accession>
    <name>Q9PR39_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">ftsH</name>
        <name evidence="17" type="ordered locus">UU105</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688776.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9PR39"/>
    <dbReference type="STRING" id="273119.UU105"/>
    <dbReference type="EnsemblBacteria" id="AAF30511">
        <property type="protein sequence ID" value="AAF30511"/>
        <property type="gene ID" value="UU105"/>
    </dbReference>
    <dbReference type="GeneID" id="29672173"/>
    <dbReference type="KEGG" id="uur:UU105"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.111"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_14"/>
    <dbReference type="OMA" id="QVMQFGQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="17" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="16">
        <location>
            <begin position="271"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="686"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="279"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AAF30511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="721" mass="80590" checksum="61B5E87C5203BD3A" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR48</accession>
    <name>Q9PR48_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction enzyme S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hsdS-1</name>
        <name evidence="5" type="ordered locus">UU096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891674.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU096"/>
    <dbReference type="REBASE" id="4887">
        <property type="entry name" value="S.UurORF98AP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30502">
        <property type="protein sequence ID" value="AAF30502"/>
        <property type="gene ID" value="UU096"/>
    </dbReference>
    <dbReference type="GeneID" id="29672320"/>
    <dbReference type="KEGG" id="uur:UU096"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_6_1_14"/>
    <dbReference type="OMA" id="WARGAVI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="12"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="173" mass="20373" checksum="E01FCC9D278BDC76" modified="2000-10-01" version="1">MSFKHISANELKRYEKCNFGNVKLLSTGLYDGYIKYNENDNNINYGEIIALPSGGSPIIKYYNGYFIDSLNIIFSQKNKKECNLKFIYYFLIANKMLIEENYRGASVKHPNMIEIIELLIPIPHISIQNKIVEILDKLEAYTKDIGVGLPFEIKQRKKQYEYYRNKLLDFKKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR70</accession>
    <name>LGT_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="1">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lgt</name>
        <name type="ordered locus">UU075</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688652.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR70"/>
    <dbReference type="SMR" id="Q9PR70"/>
    <dbReference type="STRING" id="273119.UU075"/>
    <dbReference type="EnsemblBacteria" id="AAF30480">
        <property type="protein sequence ID" value="AAF30480"/>
        <property type="gene ID" value="UU075"/>
    </dbReference>
    <dbReference type="GeneID" id="29672166"/>
    <dbReference type="KEGG" id="uur:UU075"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_0_2_14"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000172709" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <sequence length="335" mass="38546" checksum="18289AD49C6E3111" modified="2000-10-01" version="1">MQLEIINPESTLVNDVVAHRVAFSIGSNFNIYWYGIIFVCGFLIAILTYSLRLKFHYKVPYDPGFYYIFLAIPMTIIGARLWSLAIGDAKDFFDFRSGGLAIQGGVIAGVLSAAVYFPLILRMPKYHIRDIDADGNVVIRQPSMWIYADAIIPTILIGQALGRWGNFINGEIFGAESTVNDLQWLKKAMPAVFEGMKHYFIEGNKTLFTIYQPLFLYESFFNVIVFVFIYFGLSYIKQLKIGFISMSYFFFYGVTRFSTESARAPQFSFEGTYIINSLLLIFGVLGALYVQFIAPLLRKKFLLDAIIEMFYKKKDQIHKFGELRKPEEFLFYCHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR72</accession>
    <name>Q9PR72_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="7" type="ordered locus">UU073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689029.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU073"/>
    <dbReference type="EnsemblBacteria" id="AAF30478">
        <property type="protein sequence ID" value="AAF30478"/>
        <property type="gene ID" value="UU073"/>
    </dbReference>
    <dbReference type="GeneID" id="29672326"/>
    <dbReference type="KEGG" id="uur:UU073"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.75"/>
    <dbReference type="eggNOG" id="COG1481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053282_1_0_14"/>
    <dbReference type="OMA" id="FMDNTIS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="6">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="330" mass="39072" checksum="6784DCF8E1AC2178" modified="2000-10-01" version="1">MPKSTLQEIIDNDSNKFTFSEFVKEDIYTNTDYSSTDYKVILYSFFRNNLTIKIGQKLTWIIKSQNLQIIEFILNGLDYFNNLNIEYEIMFEPDHLNKTRTNYSLLLWGDLDKLDEILKLFDDANNENFHKDRYCSNFLIGAMLSGGSIAHPLENYHLEIRCDSNNYIPLLTKALARYGLEYKIIYRNKKTIVYFKKSEIISDFLKAIRTQNSLFEFENIRIQRDFNNQQQRLNNLDISNLSKSSKAGVLTKEMILEIKKNHDEFCKQSTKFLKYCELRVQNPDCSLNELSCLLKQMFNIEISKSGLNHFNSRIKEMYEELKLKKLVFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR75</accession>
    <name>Q9PR75_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hemin transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hmuU-1</name>
        <name evidence="8" type="ordered locus">UU070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688599.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU070"/>
    <dbReference type="EnsemblBacteria" id="AAF30475">
        <property type="protein sequence ID" value="AAF30475"/>
        <property type="gene ID" value="UU070"/>
    </dbReference>
    <dbReference type="GeneID" id="29672167"/>
    <dbReference type="KEGG" id="uur:UU070"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.72"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_2_14"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="356" mass="39283" checksum="E92C19349AF5988D" modified="2000-10-01" version="1">MKINQKTNLKQKHFYLIKNLNYKQSVIIKMAGLILIAICFVFLTLAIYFDTTNGFEASINQFNFNIRGPKTLMAFFSGGAIAVAGLLLQKVTRNHLADTSVLGIGSLNIILMTVYLILIKDKTSSYLNPEMRILPLVMFLSSIFGTSIVYTLSKLGRANNEKFIIIGIALNFLFEAISVVLINPANNSLFSNQDKNLMIAFENIKNYTLGIIPNSQYIDLSLVISCSVLIALTLIPIWFLRKKIDLYETSAALASTTGINIERLKISIYLLVALLAGLEIVLVGYIALLGVIGASVARQLFGNRTGITMFAAFLIGATLVCFALLISVNFNTQVPVGFLSTTIITPYFMYLIVRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR76</accession>
    <name>Q9PR76_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron(III) dicitrate transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fecE</name>
        <name evidence="5" type="ordered locus">UU069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688512.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU069"/>
    <dbReference type="EnsemblBacteria" id="AAF30474">
        <property type="protein sequence ID" value="AAF30474"/>
        <property type="gene ID" value="UU069"/>
    </dbReference>
    <dbReference type="GeneID" id="29672141"/>
    <dbReference type="KEGG" id="uur:UU069"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.71"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_14"/>
    <dbReference type="OMA" id="SVWDVVM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="291" mass="33408" checksum="02FDB8FF9828E34C" modified="2000-10-01" version="1">MFKIFAKYFCNHQLDRNQIINASKNDALIINNLSYRYHKKLPEVLKNLSFSIKKNSFTTILGPNGCGKSTTAKAIVKLLKLKKNIIKVFDRNINELSFKQLAQLISYIPQSIEIPQGTRVIDFITFGRNPYLGFSGILGKEDKLIIDLVINEMQLHDLKEKFMQELSGGQRQKVILALCLVQDTPIILLDEPTTYLDIKNQYELLESLKKLQILRQKTIIAILHDINQAIQYSDEVFVLKNGQIYANGNPNEVITKELLKNVYNIDAQIDIVDNQKIVHKIKVKDYLSNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR91</accession>
    <name>Q9PR91_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP synthase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpD-1</name>
        <name evidence="9" type="ordered locus">UU054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688563.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU054"/>
    <dbReference type="EnsemblBacteria" id="AAF30459">
        <property type="protein sequence ID" value="AAF30459"/>
        <property type="gene ID" value="UU054"/>
    </dbReference>
    <dbReference type="GeneID" id="29672302"/>
    <dbReference type="KEGG" id="uur:UU054"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.56"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_14"/>
    <dbReference type="OMA" id="SKNIFPA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="137"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="454" mass="50917" checksum="F9E6D9F0A93EB372" modified="2000-10-01" version="1">MNNGRVIKIWSDIVEIEFKNSLPALNHLLTTHDGNTFLLVKRLVDATHARAIVVYASKDLAINDIVINTNKSFMVPVGNDSKNNIYNFWGHPLLETNKTPKYVEMNSTILNERYVDKSIEIVETGIKAIDFFMPILKGYKLGIFGGAGVGKTVLMKEIIFNLNRHKQANSNIFIGSGERSREAIELYNELTASNLMPNSVMFISKMNEAPGARTSIVPIGITAAEYLRDQNKENVLLFIDNIYRFIQAENEVSTALGKKPSVGGYQSTLESDVTHIQNRLFRNKNGSITSFQTIFLPMDDLSDPSAVAVFNHLDGKLVLSRAQAAKNIFPAFDPLASSTNAIDPKIIGERHYNAIIETKKVLKAYKDLEDVILILGFDELDAESKIIVKKALQLEMFFTQNFFMTEHFTKAPGQFVPLKETVESVIRILEGKYLKQSPDVFAYIGSNKDISQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR93</accession>
    <name>Q9PR93_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">UU052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891668.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU052"/>
    <dbReference type="EnsemblBacteria" id="AAF30457">
        <property type="protein sequence ID" value="AAF30457"/>
        <property type="gene ID" value="UU052"/>
    </dbReference>
    <dbReference type="GeneID" id="29672288"/>
    <dbReference type="KEGG" id="uur:UU052"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.54"/>
    <dbReference type="eggNOG" id="ENOG5033T9M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019559_0_0_14"/>
    <dbReference type="OMA" id="RASANNW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331078" evidence="4">
        <location>
            <begin position="23"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="721" mass="83670" checksum="6AE4F6E04FF53843" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR95</accession>
    <name>Y050_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU050</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU050</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688472.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR95"/>
    <dbReference type="SMR" id="Q9PR95"/>
    <dbReference type="STRING" id="273119.UU050"/>
    <dbReference type="EnsemblBacteria" id="AAF30455">
        <property type="protein sequence ID" value="AAF30455"/>
        <property type="gene ID" value="UU050"/>
    </dbReference>
    <dbReference type="GeneID" id="29672129"/>
    <dbReference type="KEGG" id="uur:UU050"/>
    <dbReference type="eggNOG" id="ENOG5033TK5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079868_0_0_14"/>
    <dbReference type="OMA" id="ILLIDIM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220792" description="Uncharacterized protein UU050">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <sequence length="304" mass="36054" checksum="5135C0B320AB11FD" modified="2000-10-01" version="1">MQLKDLINKKKNLNNINLKVSNERNIFLINIMKLNQRLTFFSKNAFEIKESILSLKRIYNIKHDMLRHEERKIFKFLNKINDRVLWIYLTEEQKYSTDSYSRYEQKILKTIKSNRDDFILIGQGAIEFGKNHNLNVLQTFNDSNIKNLTTQLTKMIMILYTFDNYKKVNFVINSNKNYDGHFTILPMNEFSFDKFINLQKCDSNIIDFQKVKIYPNLNEFINVQINVFLVNIINTLITESSFYKTKNGLVATNNILKELDDNLSKIQRKITRVKTELQIEEINLLARQNMNEDDNDNDGGVYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB4</accession>
    <name>Q9PRB4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891654.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30436">
        <property type="protein sequence ID" value="AAF30436"/>
        <property type="gene ID" value="UU031"/>
    </dbReference>
    <dbReference type="GeneID" id="29672298"/>
    <dbReference type="KEGG" id="uur:UU031"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.33"/>
    <dbReference type="eggNOG" id="ENOG502ZGQ0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1057464_0_0_14"/>
    <dbReference type="OMA" id="FINFILM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="254" mass="30051" checksum="E7C6F22D1C85EF34" modified="2000-10-01" version="1">MAIVAKINGNASEWYHAPIALAFFLRFSLINKIFAIILSCIFCVSIYRFRKKLVQYENFNEIKSIKNNAILTVIFSVVAILSLTLFINLMIVFINQNYYYIKRIHNLLIPIRIDEIKILEYSYIYLLRCGFYILLTVFIAKFIHDKRSMIKVLSLYLFVNFILMIIGTSFTFLEHTNFYNGMLTYWTTFSCGLLYPEIINDNFQWISSFNYNLKNTIYENNFIAYLPYFCSFIVLIILIKKVSWKSITISSNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB7</accession>
    <name>Q9PRB7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ABC substrate-binding protein-iron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ABCsbp-3</name>
        <name evidence="1" type="ordered locus">UU028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688534.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU028"/>
    <dbReference type="EnsemblBacteria" id="AAF30433">
        <property type="protein sequence ID" value="AAF30433"/>
        <property type="gene ID" value="UU028"/>
    </dbReference>
    <dbReference type="GeneID" id="29672202"/>
    <dbReference type="KEGG" id="uur:UU028"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.28"/>
    <dbReference type="HOGENOM" id="CLU_1119780_0_0_14"/>
    <dbReference type="OMA" id="YDQKQKT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="248" mass="29022" checksum="EBA771594A4D04D7" modified="2000-10-01" version="1">MKIKLKKIIMSFLGLPILAIPLIVSACSQFKINQDVILTYRPTVSLAKEFANDNNTIDDVLKKVKINKDGSNNLLVYDLSRNPKNVQYKIVDIKKDSEQILKVTINAKIQKYKESINYDFYFQPFLTPKQKEDKTILQQNLNIIKSAWDYDQKQKIGFFNLRIKPEYQKRSLVEIKTLGEKAFNFGEDLIPQLKVDSKFKDINIKIIDINYFEPLDERQRELVVEIMISKGKNEQQAQLFKKIKINLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC2</accession>
    <name>Q9PRC2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrichrome ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fatD-1</name>
        <name evidence="8" type="ordered locus">UU023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU023"/>
    <dbReference type="EnsemblBacteria" id="AAF30428">
        <property type="protein sequence ID" value="AAF30428"/>
        <property type="gene ID" value="UU023"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU023"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067576_0_0_14"/>
    <dbReference type="OMA" id="MMSSWKL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="341" mass="38506" checksum="56CAB16A0CD2FC99" modified="2000-10-01" version="1">MKIKLKFENKLNFKKYLIYKWSVFVVLVLLTSFIFIFNIIYTNKTFIWESFYFQNASFEEVFLLFFYSPIVLLVCGAGLVCSGFSLQSTTRNGLAGPSTLGIFPLAALGNILSQLITKSFSNIFIGYVFGIIFSLFALGINFLFIRISPHKKTFKPIIFGFSLGAIITAVNILIANFNSSIVASPIQLLGSIGVYNSIERFYIGTPIVFISTIILLCYAKKIQILDTDHYLAKSLGIDVNKVFWITSTCSIFIAISTTFLIGGLSLIAIVMPHLVRLLFKRTNYLFQMIIAIFLTTFLLELLGIIVEFFSKFNIVFLVATVFAIPMIVLLKWELGWKVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-12-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC4</accession>
    <name>Q9PRC4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lip3</name>
        <name evidence="2" type="ordered locus">UU021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU021"/>
    <dbReference type="ESTHER" id="urepa-LIP3">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30426">
        <property type="protein sequence ID" value="AAF30426"/>
        <property type="gene ID" value="UU021"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU021"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_41_1_14"/>
    <dbReference type="OMA" id="NWINEID"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="289" mass="34098" checksum="A8B822CF67993132" modified="2000-10-01" version="1">MIMELIKTNTLNFYFEPSKSELKKGSIVFIHGLDASPHYFFLINKDLSDYDCYFVGLPAHGLTPINNKKDLNIKVFAELFINWINEIDLKEFHLLGHSLGAGIASLVSFIIPQRIEKLILVCPYHYQYLNPFLNKKLFNAWVLFPNPFLKFKTDVVLKKLYIDYRNNYKTLIETRWESISREYPRIARDVLFLCLSLLNIKINHELKMAQRNLIMPTLIMVSRHDQLIDFNLAIKVFKNNNKVNQYIFNNSGHIPFIEEPKLFTNILLSFLEDRFVEQEENDNNDINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD0</accession>
    <name>Q9PRD0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylgalactoside permease ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mglA</name>
        <name evidence="5" type="ordered locus">UU015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688670.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU015"/>
    <dbReference type="EnsemblBacteria" id="AAF30420">
        <property type="protein sequence ID" value="AAF30420"/>
        <property type="gene ID" value="UU015"/>
    </dbReference>
    <dbReference type="GeneID" id="29672264"/>
    <dbReference type="KEGG" id="uur:UU015"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.15"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_14"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="279"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="535" mass="59726" checksum="5F5EA05D9D02A993" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD4</accession>
    <name>RL7_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">UU011</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688489.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRD4"/>
    <dbReference type="SMR" id="Q9PRD4"/>
    <dbReference type="STRING" id="273119.UU011"/>
    <dbReference type="EnsemblBacteria" id="AAF30416">
        <property type="protein sequence ID" value="AAF30416"/>
        <property type="gene ID" value="UU011"/>
    </dbReference>
    <dbReference type="GeneID" id="29672193"/>
    <dbReference type="KEGG" id="uur:UU011"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_14"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000157600" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <sequence length="121" mass="12711" checksum="51F61FA77DD4E4FA" modified="2000-10-01" version="1">MSKLTIEQFIAAIKEMSMLELNDLVKAIETEFGVSAAAPVAAAAAPVAAEAPTEVTIKLVEAGTNKVGVIKLIREITGLGLMEAKTAAETAGSVIKEDVKTEEANEIKKKFDELGAKVQLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD8</accession>
    <name>Y007_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU007</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU007</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">To U.parvum UU008, UU041 and UU042.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688754.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRD8"/>
    <dbReference type="STRING" id="273119.UU007"/>
    <dbReference type="EnsemblBacteria" id="AAF30412">
        <property type="protein sequence ID" value="AAF30412"/>
        <property type="gene ID" value="UU007"/>
    </dbReference>
    <dbReference type="GeneID" id="29672274"/>
    <dbReference type="KEGG" id="uur:UU007"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1453826_0_0_14"/>
    <dbReference type="OMA" id="LVPEAYT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220780" description="Uncharacterized protein UU007">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="186" mass="20203" checksum="5E06ADDB87B58CAB" modified="2000-10-01" version="1">MLNILNNVSNSSLYSAASNATAQTGSNLINDLVPETLTASGISIAISVFSVIGTIVIALSVLPQTIKTLREKDTASLSLLLFLLNGIATAFLTLYGIGLVTVHPNSFSFLVDIKNGMFIYNREEWVAGYLICGIFLIMGEALCSVTSFIVLFCKVNNMIKAKKMGMSEEEYYEKQIKPFLKVKGAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRE0</accession>
    <name>RF1_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Peptide chain release factor 1</fullName>
            <shortName>RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">prfA</name>
        <name type="ordered locus">UU003</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688457.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRE0"/>
    <dbReference type="SMR" id="Q9PRE0"/>
    <dbReference type="STRING" id="273119.UU003"/>
    <dbReference type="EnsemblBacteria" id="AAF30410">
        <property type="protein sequence ID" value="AAF30410"/>
        <property type="gene ID" value="UU003"/>
    </dbReference>
    <dbReference type="GeneID" id="29672265"/>
    <dbReference type="KEGG" id="uur:UU003"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_14"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177765" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="359" mass="40577" checksum="4ADABAA2E2164AA5" modified="2000-10-01" version="1">MEYNKKLYEAIERVAIKNDALKKELETVVTDFKKIKEINIQLKKTTKIAEAFAKYKQKLDTGIAAEKILNTEKDLELIELAQMDLDEAKINIPIIENDLKIMLLPTDPNDDKNVIVEMRPAAGGDESSIFVGNLFDTYRAYAENNNWKMKIIEMTPNAVGFSFISFMISGEEVYSRMKFESGVHRVQRVPATESKGRVHTSTITVAVLPEQDEVDVVINPTELRIDTYRASGAGGQHVNRTESAVRITHIPTGVVAACQEGKSQIENRETAMKMLRAKLWEAAQEQQNAEFANLRKNQVGTGDRSEKIRTYNYPQNRVTDHRINLTLNKLDQIMMGELDEIIDALIADEQTGLMANLDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>P0C7K7</accession>
    <accession>Q60058</accession>
    <accession>Q9PQ56</accession>
    <accession>Q9R3U4</accession>
    <name>URE1_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease subunit alpha</fullName>
            <ecNumber evidence="1">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureC</name>
        <name type="ordered locus">UU432</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="647" last="655">
            <title>Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli.</title>
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8550495"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="2725" last="2725">
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8626347"/>
        </citation>
        <scope>ERRATUM OF PUBMED:8550495</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="submission" date="2000-09" db="EMBL/GenBank/DDBJ databases">
            <title>Phylogenetic study of Ureaplasma parvum and Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Kong F."/>
                <person name="Gilbert G.L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Int. J. Syst. Bacteriol." volume="49" first="1879" last="1889">
            <title>Phylogenetic analysis of Ureaplasma urealyticum -- support for the establishment of a new species, Ureaplasma parvum.</title>
            <authorList>
                <person name="kong F."/>
                <person name="James G."/>
                <person name="Ma Z."/>
                <person name="Gordon S."/>
                <person name="Bin W."/>
                <person name="Gilbert G.L."/>
            </authorList>
            <dbReference type="PubMed" id="10555372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-135</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
            <strain>ATCC 27818 / Pi / Serovar 6</strain>
            <strain>ATCC 33697 / U26 / Serovar 14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="1">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="1"/>
    <dbReference type="EMBL" id="L40489">
        <property type="protein sequence ID" value="AAA89189.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085730">
        <property type="protein sequence ID" value="AAD28136.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085731">
        <property type="protein sequence ID" value="AAD28139.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085733">
        <property type="protein sequence ID" value="AAD28145.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G82890">
        <property type="entry name" value="G82890"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688455.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0C7K7"/>
    <dbReference type="SMR" id="P0C7K7"/>
    <dbReference type="STRING" id="273119.UU432"/>
    <dbReference type="MEROPS" id="M38.982"/>
    <dbReference type="EnsemblBacteria" id="AAF30844">
        <property type="protein sequence ID" value="AAF30844"/>
        <property type="gene ID" value="UU432"/>
    </dbReference>
    <dbReference type="GeneID" id="29672358"/>
    <dbReference type="KEGG" id="uur:UU432"/>
    <dbReference type="eggNOG" id="COG0804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_14"/>
    <dbReference type="OMA" id="GFDSHIH"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000067563" description="Urease subunit alpha">
        <location>
            <begin position="1"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA89189." evidence="2" ref="1">
        <original>I</original>
        <variation>L</variation>
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 4; AAD28136/AAD28139." evidence="2" ref="4">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA89189." evidence="2" ref="1">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="598" mass="64545" checksum="5760DA36AC021424" modified="2008-05-20" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q56561</accession>
    <name>UREG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureG</name>
        <name type="ordered locus">UU429</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="647" last="655">
            <title>Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli.</title>
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8550495"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="L40489">
        <property type="protein sequence ID" value="AAA89192.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G82893">
        <property type="entry name" value="G82893"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688745.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56561"/>
    <dbReference type="SMR" id="Q56561"/>
    <dbReference type="STRING" id="273119.UU429"/>
    <dbReference type="EnsemblBacteria" id="AAF30841">
        <property type="protein sequence ID" value="AAF30841"/>
        <property type="gene ID" value="UU429"/>
    </dbReference>
    <dbReference type="GeneID" id="29672328"/>
    <dbReference type="KEGG" id="uur:UU429"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072144_1_0_14"/>
    <dbReference type="OMA" id="VDLTIYV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0996">Nickel insertion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000067675" description="Urease accessory protein UreG">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <sequence length="206" mass="22509" checksum="51A64E8C4A9A52E7" modified="1996-11-01" version="1">MKRPLIIGVGGPVGAGKTMLIERLTRYLSTKGYSMAAITNDIYTKEDARILLNTSVLPADRIAGVETGGCPHTAIREDASMNFAAIEEMCDKHPDLQLLFLESGGDNLSATFSPDLVDFSIYIIDVAQGEKIPRKGGQGMIKSDLFIINKVDLAPYVGANVEVMKADTLKSRGNKDFFVTNLKTDEGLKSVADWIEKRLQLALLEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPN6</accession>
    <name>RNPA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease P protein component</fullName>
            <shortName evidence="1">RNase P protein</shortName>
            <shortName evidence="1">RNaseP protein</shortName>
            <ecNumber evidence="1">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnpA</name>
        <name type="ordered locus">UU603</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688777.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPN6"/>
    <dbReference type="SMR" id="Q9PPN6"/>
    <dbReference type="STRING" id="273119.UU603"/>
    <dbReference type="EnsemblBacteria" id="AAF31017">
        <property type="protein sequence ID" value="AAF31017"/>
        <property type="gene ID" value="UU603"/>
    </dbReference>
    <dbReference type="GeneID" id="29672643"/>
    <dbReference type="KEGG" id="uur:UU603"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_9_4_14"/>
    <dbReference type="OMA" id="AWFIAAN"/>
    <dbReference type="BRENDA" id="3.1.26.5">
        <property type="organism ID" value="9209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000198561" description="Ribonuclease P protein component">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <sequence length="113" mass="13282" checksum="8804D398B4CDE812" modified="2000-12-01" version="1">MANFISLKKNEDILDTIKKQQKIHSNQIVVYFRKTNLKNVRLAISISKKKFKLATQRNRIRRLIKAWFIAADIPIKSYDIVVLVKPSFIDGSFVLNCNNLKIILQRIINKEKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPN9</accession>
    <name>ISPE_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="1">CMK</shortName>
            <ecNumber evidence="1">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispE</name>
        <name type="ordered locus">UU600</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688809.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPN9"/>
    <dbReference type="SMR" id="Q9PPN9"/>
    <dbReference type="STRING" id="273119.UU600"/>
    <dbReference type="EnsemblBacteria" id="AAF31014">
        <property type="protein sequence ID" value="AAF31014"/>
        <property type="gene ID" value="UU600"/>
    </dbReference>
    <dbReference type="GeneID" id="29672539"/>
    <dbReference type="KEGG" id="uur:UU600"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_2_0_14"/>
    <dbReference type="OMA" id="RWPSPAK"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000235150" description="4-diphosphocytidyl-2-C-methyl-D-erythritol kinase">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <sequence length="265" mass="31101" checksum="5BDB2B08425315BB" modified="2000-10-01" version="1">MKVKSFAKIDLGYSVYKKQKNFTKHDFESIFILVENIYDDIEITKIEKNIDDVHYYNETNEIYVYSRLVHKTLEWIRHTYHIKNHYRINIKKRIPIGAGLGGGSSNAAAIMKYILEFEGIKEINYKDVVNKLGADIPFFLSGYKTAYISDYGSVLEDLTGQFKLNYEVYLMNVNVNTKIVFEKFDDNSWHVIKNNFKTIIKNLKENIVVNIHNDLQEYCFELYPNIKYKYNELLSDGFYTILSGAGSSFIRIKLKNKEDLIINEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-30" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP0</accession>
    <name>SYE_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">UU599</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688453.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPP0"/>
    <dbReference type="SMR" id="Q9PPP0"/>
    <dbReference type="STRING" id="273119.UU599"/>
    <dbReference type="EnsemblBacteria" id="AAF31013">
        <property type="protein sequence ID" value="AAF31013"/>
        <property type="gene ID" value="UU599"/>
    </dbReference>
    <dbReference type="GeneID" id="29672199"/>
    <dbReference type="KEGG" id="uur:UU599"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_1_14"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000119690" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <sequence length="482" mass="55909" checksum="3977C1BCFA31C16C" modified="2000-10-01" version="1">MKIRTRYAPSPTGYLHIGGARTALFNYLLAKAYGGDFIIRIEDTDIERNVEGGINSQLDFLAWMGIIPDESIRNPKAFGPYIQSEKLKHYEKLALDLVDQKKAYFCFCSKEQLDADRELAEKSHQTPKYKRHCLNLDKKTIESNLLQNKEYTIRLKINENMEYSWDDLIRGKISIPGSALTDPVILKSNKIAMYNFAVVIDDYEMQISHVIRGEEHISNTPYQLAIAQALNYDITKIKYGHLSIIVDETGKKLSKRNLSLKQFVSDYEKDGYWPHAITNFVALLGWSPKNNDEIMSLETMIKNFDINNLSKSPAFFDINKMNWFSTQYFNNITQEEFINFIKKHSLTKELVLNDYTFINKCLLFKSHIINLKQLIDLVIEQFNCDKKVLASDVDYIKKNQLITVVRVFYEQLIINDEFNEEFIKEIIKKVQIITNNKGANLYMPIRIATTFSSHGPELAKTICYLGREKVLKNLINILKILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP4</accession>
    <name>Q9PPP4_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gtp1</name>
        <name evidence="4" type="synonym">ychF</name>
        <name evidence="7" type="ordered locus">UU595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688686.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU595"/>
    <dbReference type="EnsemblBacteria" id="AAF31009">
        <property type="protein sequence ID" value="AAF31009"/>
        <property type="gene ID" value="UU595"/>
    </dbReference>
    <dbReference type="GeneID" id="29672679"/>
    <dbReference type="KEGG" id="uur:UU595"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.618"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_14"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="281"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF31009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="368" mass="41232" checksum="71B67A7D8443254A" modified="2000-10-01" version="1">MSLSAGLVGLPNVGKSTLFNTITNSRVEAANYPFATIEPNIGIVNINDPRLKRLASLVVPDKIVPTTFKFVDIAGLVKGASQGEGLGNQFLNNIRDVDAICHVVRCFDDKSITHVHNKIDALSDIHVINYELILSDLDIIEKRISRIKKKADSGDKDARREYLILFNIEEALKKGQLASSVKLTKEELKIINSFNLITLKPILYIANISENEISNPDLNKEYLKVKKYAQDNDARCVALSAKIEYEISILDEESKSIFIQDLGIKTTGLDEIVKQTYDLLNLKTYFTYGKQEVRAWTFINGMSAPECAGIIHSDFEKGFIKAEIMHYDDLISLGSEQAVKEAGKIRMEGKSYLMKDGDICNFRFNVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP7</accession>
    <name>Q9PPP7_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688464.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU592"/>
    <dbReference type="EnsemblBacteria" id="AAF31006">
        <property type="protein sequence ID" value="AAF31006"/>
        <property type="gene ID" value="UU592"/>
    </dbReference>
    <dbReference type="GeneID" id="29672553"/>
    <dbReference type="KEGG" id="uur:UU592"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.615"/>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_1_0_14"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019991">
        <property type="entry name" value="GTP-bd_ribosome_bgen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03596">
        <property type="entry name" value="GTPase_YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="120"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="126"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF31006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="273" mass="32178" checksum="47B58CE712166514" modified="2000-10-01" version="1">MDIINKKINWFPGHMKKATDEILKNLKNVDFFIQLVDARCPLTSSNIELLKEVSSKPVINLANKADLSDWKKNFDNNFLLISTKKRNDKNKIIQHLYQLFDQKIKIYQKKGLINPKFVGMIIGLPNIGKSSLINFLAPKKVLKVENRPGVTKTQCIRQINQHFYLIDTPGIFLKNIQNERDSFVLTLINCVKKEVLELESIVHFAYDFYLKNYRNELFIKYKMNKVLNFDDFIHHICELYNYKLTNNEFDHVRAYENLFNDFSNGLICKVNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ0</accession>
    <name>Q9PPQ0_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trx</name>
        <name evidence="6" type="ordered locus">UU589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688452.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU589"/>
    <dbReference type="EnsemblBacteria" id="AAF31003">
        <property type="protein sequence ID" value="AAF31003"/>
        <property type="gene ID" value="UU589"/>
    </dbReference>
    <dbReference type="GeneID" id="29672600"/>
    <dbReference type="KEGG" id="uur:UU589"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.612"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_14"/>
    <dbReference type="OMA" id="KIKICKF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF31003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="106" mass="12216" checksum="3EE681D8DEE3E32F" modified="2000-10-01" version="1">MLIKLESNQNLNELLKENHSKPILIDFYADWCPPCRMLIPVLDSIEKKHGDEFTIIKINVDHFPELSTQYQVKSIPALFYLKNGDIKATSLGFIDENSLVNKLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ5</accession>
    <name>Q9PPQ5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA damage inducible protein-MATE transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dinF-2</name>
        <name evidence="2" type="ordered locus">UU584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688716.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU584"/>
    <dbReference type="EnsemblBacteria" id="AAF30998">
        <property type="protein sequence ID" value="AAF30998"/>
        <property type="gene ID" value="UU584"/>
    </dbReference>
    <dbReference type="GeneID" id="29672296"/>
    <dbReference type="KEGG" id="uur:UU584"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.607"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040650_0_0_14"/>
    <dbReference type="OMA" id="YILIYGN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="520" mass="59172" checksum="CE4A63CF8D091CA7" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ7</accession>
    <name>Q9PPQ7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deaD</name>
        <name evidence="3" type="ordered locus">UU582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688762.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU582"/>
    <dbReference type="EnsemblBacteria" id="AAF30996">
        <property type="protein sequence ID" value="AAF30996"/>
        <property type="gene ID" value="UU582"/>
    </dbReference>
    <dbReference type="GeneID" id="29672250"/>
    <dbReference type="KEGG" id="uur:UU582"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.605"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_14"/>
    <dbReference type="OMA" id="YDIELYQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="227"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="443" mass="51753" checksum="56A7F62944F46A5C" modified="2000-10-01" version="1">MKFNSNYQKWILDSLINQKIFEPTPIQLKTMPLIAKRENIIGVAPTGTGKTLAFVLPILNNLDLSQKLQVIIITPTRELARQIFSKIIVFKKHQPLLQVKMLIGGESIDQQINSQLNKSQLLIATPTRLKQILTRQILDLHHVNALVFDEADMLMDLGFISDLEFINSQFTNKDVQKISFSATLHEMLSIQLKKYFKNTKIINISNSIYENKKITHYVIHNHDKWHSLSIIMKTIKPYLCIIFANTKKEVEAIYQYLIQQNKNVCILHGSLLQRERKNNYRDIKNNKFQYVVASDIASRGLDIDGVSHIINWNLPTENEWYIHRAGRSGRGKYSGESYVLYDQKEHDKLLNLSKKGIVFHHKFIKENELFDKEFLFKKKNQFKDLKTQNEIQKIISTTSTKIKPGYKKKIKEAIQKINQKNKRSHIEKKMNAHRIRGYKLKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ9</accession>
    <name>Q9PPQ9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">UU580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688437.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU580"/>
    <dbReference type="EnsemblBacteria" id="AAF30994">
        <property type="protein sequence ID" value="AAF30994"/>
        <property type="gene ID" value="UU580"/>
    </dbReference>
    <dbReference type="GeneID" id="29672241"/>
    <dbReference type="KEGG" id="uur:UU580"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.603"/>
    <dbReference type="HOGENOM" id="CLU_1601994_0_0_14"/>
    <dbReference type="OMA" id="NEMIDEH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="166" mass="19897" checksum="A1C06A981CE76EE2" modified="2000-10-01" version="1">MVNDKKQKSNKYLTYQDQEYERNLLLEKERKQQKKILAQQAYQQLDLNKKLIKKAKNDQKLILRLLKEDKSISKTQFNTHRLELKNTIDQMVDEYYELLEQYSVDFEKISFKLKRWLYGINKEIRRTTWASKRSVIISLIIVIVIVLILAAIFFGIDTGFYKLSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR5</accession>
    <name>Q9PPR5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688475.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU574"/>
    <dbReference type="EnsemblBacteria" id="AAF30988">
        <property type="protein sequence ID" value="AAF30988"/>
        <property type="gene ID" value="UU574"/>
    </dbReference>
    <dbReference type="GeneID" id="29672148"/>
    <dbReference type="KEGG" id="uur:UU574"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.597"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_915116_0_0_14"/>
    <dbReference type="OMA" id="LKKNMYY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029465">
        <property type="entry name" value="ATPgrasp_TupA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14305">
        <property type="entry name" value="ATPgrasp_TupA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="305" mass="37276" checksum="53FC80D78C61DF1F" modified="2000-10-01" version="1">MITDKLIKELNEITRLYYKNDRNQFKKSLINIWSKTMGYTPNLQDPKTYNEKLLYMYLNTDQSKILEIVDKISFKKWLIKHRLYQYQVPTLAIFNRQNQITLLDLNKFPKPYIIKLNNSTENEDLYIIRETTSQAELTQIITHFNNILLNKKINHPRNFYETWCYSQIKPQVLIEPLLGKQTLVADYKIFCFAQEQFCLYMNKDEIEKNNWNWDFLKSNIFDLKNNKSILNHEIINFDFSEIKDVCQKIYEVLKNDFKHFRIDFYYVDHRLYIGEITFNTSNAFFTFWDDPQWKQKDIEWGKYWK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-12-06" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS2</accession>
    <name>TRMD_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber>2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">trmD</name>
        <name type="ordered locus">UU567</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688650.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPS2"/>
    <dbReference type="SMR" id="Q9PPS2"/>
    <dbReference type="STRING" id="273119.UU567"/>
    <dbReference type="EnsemblBacteria" id="AAF30981">
        <property type="protein sequence ID" value="AAF30981"/>
        <property type="gene ID" value="UU567"/>
    </dbReference>
    <dbReference type="GeneID" id="29672713"/>
    <dbReference type="KEGG" id="uur:UU567"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_14"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000060491" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="228" mass="26134" checksum="EB53BA36D6E9D4C6" modified="2000-10-01" version="1">MKISILSLFPELYETWIKHSIISNAIKNNQVIIEVIDFRLYTNDKHKKVDDYQYGGGAGMVLRIEPIVAAIRAIRSSNSYVILTTPKGQVFNQELANNFVSKYDHIIIIAGHYEGFDERINYYIDAQYSIGDFVLTGGELPSMVISDAVIRLLDGVISPSSLETESFNNYLLDYPVYTRPLVFEGHKVPDILLSGHHKNIADFRKQQQETITKKNRPDLYQKYLNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT5</accession>
    <name>Q9PPT5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688484.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU555"/>
    <dbReference type="EnsemblBacteria" id="AAF30968">
        <property type="protein sequence ID" value="AAF30968"/>
        <property type="gene ID" value="UU555"/>
    </dbReference>
    <dbReference type="GeneID" id="29672565"/>
    <dbReference type="KEGG" id="uur:UU555"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.576"/>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098671_1_0_14"/>
    <dbReference type="OMA" id="GYLPYDH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="169" mass="19976" checksum="66A971AB6ECA74B5" modified="2000-10-01" version="1">MVLIEKINEQDINTVVAYVVAFRKKLYPKVDHNNLPKELVNFKQTYIINPLGIWFSVFLEDTHELVGTISCHEYDYRYNNLFYLDRSTKTSEVGKLYIDPLIRRQGIATRLFNALKDQAKKQGIKCFYLHTHHHLPGAREFWLKMGFKIQKEMTLEDDGQDIIHMTLEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT8</accession>
    <name>RS18_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name evidence="1" type="synonym">rps18</name>
        <name type="ordered locus">UU552</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688517.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPT8"/>
    <dbReference type="SMR" id="Q9PPT8"/>
    <dbReference type="STRING" id="273119.UU552"/>
    <dbReference type="EnsemblBacteria" id="AAF30965">
        <property type="protein sequence ID" value="AAF30965"/>
        <property type="gene ID" value="UU552"/>
    </dbReference>
    <dbReference type="GeneID" id="29672529"/>
    <dbReference type="KEGG" id="uur:UU552"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_2_2_14"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000111257" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <sequence length="79" mass="9136" checksum="E4697FD3F03F5AC4" modified="2000-10-01" version="1">MAKVTNNRNRKPRKKVCILSAKGIEHVDYKDVELLQRFINNNNKIASRRVTGASARMQRRIANAIKRARFVGLLPYVKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-08" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU2</accession>
    <name>UNG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uracil-DNA glycosylase</fullName>
            <shortName>UDG</shortName>
            <ecNumber>3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ung</name>
        <name type="ordered locus">UU548</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688756.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPU2"/>
    <dbReference type="SMR" id="Q9PPU2"/>
    <dbReference type="STRING" id="273119.UU548"/>
    <dbReference type="EnsemblBacteria" id="AAF30961">
        <property type="protein sequence ID" value="AAF30961"/>
        <property type="gene ID" value="UU548"/>
    </dbReference>
    <dbReference type="GeneID" id="29672495"/>
    <dbReference type="KEGG" id="uur:UU548"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_3_2_14"/>
    <dbReference type="OMA" id="PDNGYLM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176160" description="Uracil-DNA glycosylase">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="212" mass="24807" checksum="26A66F0F2C07B1DE" modified="2000-10-01" version="1">MKWKEFIINETKQSYLKNIIKKINNIENHQVVFPLKKQRFRCFDFFDIEQTKVVILGQDPYHTPKIANGLCFSVDLGNNLPGSLINIFKALEYDLQIKRTNPDLSDWAKQGVLLLNTVLTVNAHQPNSHKNFGYEELIKNVFNELRKQKHVVYLLWGKQAMSYINLIDQKQNLILCASHPSPLSAHRGFLTCKHFSKCNDYLIKHLRTPIKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-25" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU6</accession>
    <name>GATB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName>Asp/Glu-ADT subunit B</shortName>
            <ecNumber>6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gatB</name>
        <name type="ordered locus">UU544</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891814.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPU6"/>
    <dbReference type="SMR" id="Q9PPU6"/>
    <dbReference type="STRING" id="273119.UU544"/>
    <dbReference type="EnsemblBacteria" id="AAF30957">
        <property type="protein sequence ID" value="AAF30957"/>
        <property type="gene ID" value="UU544"/>
    </dbReference>
    <dbReference type="GeneID" id="29672464"/>
    <dbReference type="KEGG" id="uur:UU544"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.565"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_14"/>
    <dbReference type="OMA" id="QIYAYEN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148864" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="477" mass="55279" checksum="34BCB5B61C6D6F97" modified="2000-10-01" version="1">MQNFEVIIGIEVHTALNTKTKMFSNAATSHKSIPNTLINEIDLALPGTLPTVNQEVVHKGLFLANALHMRTNHQFIAFDRKHYYYLDLPKGYQITQNYFPIGQNGYIQIIDEYNNLKRIRIKQIHLEEDTAKQTNIGNQIYLDYNRAGWPLIEIVSEADLRSAQETVLFLEELRKILLFNDISDAKMEDGSLRVDVNVSIRPQGAKKFGTKVEIKNINSISNVAKAIDYEIRRQLNLILLNQNVEQQTRRFDDNTNTTVFMRSKNDAINYRYIREANIAPIHLSDDYVKKMFLTKSCSINDLRQQLAQKGLVSSAIEQLLSDGPLFKAFKYVDKIVNNPLSVYKWLCLEFIGLINKNTQNIEEITPELLQKIARMILLFDQTLINGKQTKIILEKIYLTNKDPQILIKELGFEQITNENEITKLWHQILAKNQEMLLQYNERPDRVEKFFMGEIMKLTKAQANPTISFNVLKKILQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV1</accession>
    <name>ECFA1_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Energy-coupling factor transporter ATP-binding protein EcfA1</fullName>
            <shortName evidence="1">ECF transporter A component EcfA1</shortName>
            <ecNumber evidence="1">7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ecfA1</name>
        <name type="synonym">cbiO1</name>
        <name type="ordered locus">UU539</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688425.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPV1"/>
    <dbReference type="SMR" id="Q9PPV1"/>
    <dbReference type="STRING" id="273119.UU539"/>
    <dbReference type="EnsemblBacteria" id="AAF30952">
        <property type="protein sequence ID" value="AAF30952"/>
        <property type="gene ID" value="UU539"/>
    </dbReference>
    <dbReference type="GeneID" id="29672427"/>
    <dbReference type="KEGG" id="uur:UU539"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_14"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030947">
        <property type="entry name" value="EcfA_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04520">
        <property type="entry name" value="ECF_ATPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51246">
        <property type="entry name" value="CBIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092125" description="Energy-coupling factor transporter ATP-binding protein EcfA1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="27"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01710"/>
        </source>
    </evidence>
    <sequence length="294" mass="32829" checksum="E1975CFEFE1D052D" modified="2000-10-01" version="1">MSHNDKNTHNYQISSLDKIINDSSVAIEFENVYFAYTEERMILKNVSFTINDNEYVCVIGHNGSGKSTISKVLTGLLKPKSGVIKLFGIEISAANLKYLRNNIGIVFQNPDNQFVGITAEDDIAFGLENRKVPPNKMWDIINDAAVATGIEDLLKKESLELSGGQKQRVAIASVLAINPKVIIFDESTSMLDPKGKNELKELMVSLRDVAKKTIISITHDMEEVVKADKVIVMSNGEVQYIGTPQEIFANEERLLKMQLDIPFTLKLAKTLKEKGLKIDLTLNNEELIEKICKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV6</accession>
    <name>SYT_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="1">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrS</name>
        <name type="ordered locus">UU534</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688784.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPV6"/>
    <dbReference type="SMR" id="Q9PPV6"/>
    <dbReference type="STRING" id="273119.UU534"/>
    <dbReference type="EnsemblBacteria" id="AAF30947">
        <property type="protein sequence ID" value="AAF30947"/>
        <property type="gene ID" value="UU534"/>
    </dbReference>
    <dbReference type="GeneID" id="29672404"/>
    <dbReference type="KEGG" id="uur:UU534"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_3_1_14"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000101081" description="Threonine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="179"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <sequence length="580" mass="67752" checksum="328CFE3AFD662E16" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX1</accession>
    <name>Q9PPX1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689081.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU518"/>
    <dbReference type="EnsemblBacteria" id="AAF30931">
        <property type="protein sequence ID" value="AAF30931"/>
        <property type="gene ID" value="UU518"/>
    </dbReference>
    <dbReference type="GeneID" id="29672312"/>
    <dbReference type="KEGG" id="uur:UU518"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.538"/>
    <dbReference type="HOGENOM" id="CLU_179056_3_0_14"/>
    <dbReference type="OMA" id="HLTINKQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018691">
        <property type="entry name" value="DUF2188"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09954">
        <property type="entry name" value="DUF2188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="72" mass="8438" checksum="6E93E955DE98989C" modified="2000-10-01" version="1">MASEDKVVYYLSPNEDKGWKIFKKGGERATKLFSTKKEALEYIKTLGRNQNAVVYIQTKDGKFQDVRNYRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPZ8</accession>
    <name>Q9PPZ8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891799.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU492"/>
    <dbReference type="EnsemblBacteria" id="AAF30904">
        <property type="protein sequence ID" value="AAF30904"/>
        <property type="gene ID" value="UU492"/>
    </dbReference>
    <dbReference type="GeneID" id="29672341"/>
    <dbReference type="KEGG" id="uur:UU492"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.509"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066632_5_0_14"/>
    <dbReference type="OMA" id="SICEIDY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="238" mass="28148" checksum="A4ED99FDD40AFB4C" modified="2000-10-01" version="1">MAEIITRGYLVARQDYDVFDEILTFINEYGNRFIMFAPGTKRITSKNARALFFGNFLEIQFFYARNDTKLSKLKKVISLDQIDYKYENTYSMLILSELMTKVVNFNVEFYQFYQLILEYIILEYNDYYISCFLLVKFLIMNGVNFNFQACVHCNSSKNIKTFSLADHGLICINCESKIINKIDYEPKALQLWQKLYFATQIKKDEDKDNEIIYKGLLKILNSVLYDQLGIYLTIIKNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-03-28" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ00</accession>
    <name>YBEY_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">UU490</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688705.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ00"/>
    <dbReference type="SMR" id="Q9PQ00"/>
    <dbReference type="STRING" id="273119.UU490"/>
    <dbReference type="EnsemblBacteria" id="AAF30902">
        <property type="protein sequence ID" value="AAF30902"/>
        <property type="gene ID" value="UU490"/>
    </dbReference>
    <dbReference type="GeneID" id="29672373"/>
    <dbReference type="KEGG" id="uur:UU490"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_0_14"/>
    <dbReference type="OMA" id="LRREYCY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000102561" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <sequence length="155" mass="18449" checksum="92BE16C7641A7F1C" modified="2000-10-01" version="1">MHFLITNEVKKIFNDKLYSQRFKQITDLVSTKLNIDKKRFFECHFVDEKTIQEINKNYRNKDYITDVISFAFDDGEIITPLLGEMYICYQKVVDQASQFAHSFERELCFLFTHGLLHLLGYDHIKIEDEKIMFALQDEILNELKITRNINGARND</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ15</accession>
    <name>Q9PQ15_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688780.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU475"/>
    <dbReference type="EnsemblBacteria" id="AAF30887">
        <property type="protein sequence ID" value="AAF30887"/>
        <property type="gene ID" value="UU475"/>
    </dbReference>
    <dbReference type="GeneID" id="29672345"/>
    <dbReference type="KEGG" id="uur:UU475"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.491"/>
    <dbReference type="HOGENOM" id="CLU_444763_0_0_14"/>
    <dbReference type="OMA" id="TKDEHAN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331262" evidence="2">
        <location>
            <begin position="24"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="616" mass="71936" checksum="1B3EB4ABBD02D486" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ24</accession>
    <name>Q9PQ24_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gyrB</name>
        <name evidence="7" type="synonym">parE</name>
        <name evidence="7" type="ordered locus">UU466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891785.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU466"/>
    <dbReference type="EnsemblBacteria" id="AAF30878">
        <property type="protein sequence ID" value="AAF30878"/>
        <property type="gene ID" value="UU466"/>
    </dbReference>
    <dbReference type="GeneID" id="29672258"/>
    <dbReference type="KEGG" id="uur:UU466"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.482"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_1_2_14"/>
    <dbReference type="OMA" id="KIAYAWT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005740">
        <property type="entry name" value="ParE_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01058">
        <property type="entry name" value="parE_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="6">
        <location>
            <begin position="419"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="642" mass="72650" checksum="1235FEB2FE46210E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ36</accession>
    <name>CSD_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable cysteine desulfurase</fullName>
            <ecNumber>2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">csd</name>
        <name type="ordered locus">UU454</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689089.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ36"/>
    <dbReference type="SMR" id="Q9PQ36"/>
    <dbReference type="STRING" id="273119.UU454"/>
    <dbReference type="REBASE" id="203824">
        <property type="entry name" value="M.Bli1441DndAP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30866">
        <property type="protein sequence ID" value="AAF30866"/>
        <property type="gene ID" value="UU454"/>
    </dbReference>
    <dbReference type="GeneID" id="29672596"/>
    <dbReference type="KEGG" id="uur:UU454"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_14"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000150321" description="Probable cysteine desulfurase">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="402" mass="45636" checksum="5B251163C2CB5A23" modified="2000-10-01" version="1">MNDYKQFFPWFKNNKDVIYLDSSATSLKPQVVIDAIVDYYTKYSTNPHNTDSNFTFHTHEIMNETRANVAKFINANFDEIIFTSGATESLNLIANGLRPHLKKGDEIILTYIEHASNLLPWYKLRDDLGVKIIFANQKNQFPQLSDFLKVISPKTKVVSFASGGNLIGNVLDENLIIKNIKKIKPDVLVCVDATQSIQHRMFDVKKCKSDFMVFSAHKLLGPTGIGVAYIKNDLIKKMQPLKYGGGMNFSIDLNSYQLYDNYMKFEGGTPHVAGFYGFNAALKFLMDIGYNKIHEHELKITKYARDQLALIPEIKTYVQDATSSTITFSYNGVFCQDFANYLGSKNIIVRSGLSCAKIINNVIQTECAIRASFYIYNDFNDVDRLIKAIKEYQKGDELNGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ44</accession>
    <name>Q9PQ44_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction enzyme S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hsdS-4</name>
        <name evidence="5" type="ordered locus">UU446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891777.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU446"/>
    <dbReference type="REBASE" id="18404">
        <property type="entry name" value="S.UurORF466P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30858">
        <property type="protein sequence ID" value="AAF30858"/>
        <property type="gene ID" value="UU446"/>
    </dbReference>
    <dbReference type="GeneID" id="29672537"/>
    <dbReference type="KEGG" id="uur:UU446"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748875_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="149" mass="17702" checksum="4CA516DE2DCE1382" modified="2000-10-01" version="1">MINLNIITRDNYYYEKIGNNKPKKLENLPFNIPNNWIWVKLNNISNVISGYSFKSSKYTSSGIRIIRISDFDSKEVDNNEPIFYEYNEKFNSYKIENNDIILVMTGGTVGKNIIIKKANDYYLNQRVARIRTFNVNYNYIYYLINTTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ45</accession>
    <name>Q9PQ45_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU445"/>
    <dbReference type="REBASE" id="18405">
        <property type="entry name" value="UurORF466P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30857">
        <property type="protein sequence ID" value="AAF30857"/>
        <property type="gene ID" value="UU445"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU445"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1824512_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="141" mass="17190" checksum="3495A82F164B27F5" modified="2000-10-01" version="1">MYWYVIIKKYLDQFEQLYKNSLEQMKKDNHELLFKLQNNKNLPNQNEIFIPIEKYKKCENMLDLNICDKYAYKDLKEQNHYFDSSTESKFANRFLSLSNDNDKIKNNVELWTKNPVFHGLKYQYFNEDGQISNSYPDFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ51</accession>
    <name>Q9PQ51_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688998.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30851">
        <property type="protein sequence ID" value="AAF30851"/>
        <property type="gene ID" value="UU439"/>
    </dbReference>
    <dbReference type="GeneID" id="29672455"/>
    <dbReference type="KEGG" id="uur:UU439"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.455"/>
    <dbReference type="HOGENOM" id="CLU_2605059_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="83" mass="9511" checksum="3310FA462E9415B2" modified="2000-10-01" version="1">MIYKEIVRNIIKHPLILPDGKHYHLHKILTSKDELRKGEVTLVAENGKEYTVDLSAFVDLLVDGDCIFDDNHSLVALYFDDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ52</accession>
    <name>Q9PQ52_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Holliday junction DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ruvB-1</name>
        <name evidence="3" type="ordered locus">UU438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU438"/>
    <dbReference type="EnsemblBacteria" id="AAF30850">
        <property type="protein sequence ID" value="AAF30850"/>
        <property type="gene ID" value="UU438"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU438"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2182820_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_lid_4" evidence="2">
        <location>
            <begin position="2"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="RuvB_C" evidence="1">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="109" mass="12865" checksum="2B65A9B0CE8CD1F4" modified="2000-10-01" version="1">MIANNAKGIPRLANRLLKRVVDFKINGFNDIKSIFKKIQIYEFGLDEQDINYLNVLYRQDNEIGLKSIAQILRLDQYTIETKIEPYLIQHHFINKNLRGRKITIEGIDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-02" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ53</accession>
    <name>DPO4_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase IV</fullName>
            <shortName evidence="1">Pol IV</shortName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dinB</name>
        <name type="ordered locus">UU437</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAF30849" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30849.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D82891">
        <property type="entry name" value="D82891"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689004.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ53"/>
    <dbReference type="SMR" id="Q9PQ53"/>
    <dbReference type="STRING" id="273119.UU437"/>
    <dbReference type="EnsemblBacteria" id="AAF30849">
        <property type="protein sequence ID" value="AAF30849"/>
        <property type="gene ID" value="UU437"/>
    </dbReference>
    <dbReference type="GeneID" id="29672432"/>
    <dbReference type="KEGG" id="uur:UU437"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_1_14"/>
    <dbReference type="OMA" id="KVRRYDF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0515">Mutator protein</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173961" description="DNA polymerase IV">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="360" mass="41723" checksum="9BCEE8FD496C86FD" modified="2002-08-02" version="2">MKNNHQKIIMHLDIDAFYATVSELLHPEYKNFPIAVGSLNSRTGIISSPNYLARSYGVKAAMPIFLAKELCPNLIILPSEHNIYQSYSKHFFQIINKYTNKIEITSIDECFIDATDLVKKYHNNIRLLATKIQKEIKNKLNLSISIGISYNKTIAKMATELNKPSGISIIDENKIINLIYELNINKIPYIGEIKSQELYAINIFKIKELIATENKQKISLVLGSIYQNLVNDLKGLSKIKIIDEDIYKTISHSKTFNEDLNDFYEISNEMNDLILTVTNRLKKCNLMTNNISIYIKYPSFKTKIKQKQLTYYTDDYQTIFLAIKNLFKIMYKDETIRLIGISLNKLVKKENVKKQLFLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ55</accession>
    <name>Q9PQ55_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferrichrome transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fhuC</name>
        <name evidence="5" type="ordered locus">UU435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689086.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU435"/>
    <dbReference type="EnsemblBacteria" id="AAF30847">
        <property type="protein sequence ID" value="AAF30847"/>
        <property type="gene ID" value="UU435"/>
    </dbReference>
    <dbReference type="GeneID" id="29672412"/>
    <dbReference type="KEGG" id="uur:UU435"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.451"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_14"/>
    <dbReference type="OMA" id="FHIDAEI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="47"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="387" mass="44608" checksum="200277ADF35A3AB6" modified="2000-10-01" version="1">MSFFKKKNDLQKEEHKHVSVVDMNEILSYEDSEEFKNDEIDSNEPIFKLNNVSLGYGKKMIIKNLTATIHRNDFVVVLGPNGSGKSTLIKGLCRINNPSSGYIMYRDKLISRPLLPFLWLEKAWSSIVNIFTKDRKEVIETIDWHIQNYKKIHAYKSKELALNLAYVPQLAVFPEATSIYDFVKMGRFPSSNALGINTNTEREKQIIDEALKNVGIYEFRHKNLEDLSGGQKQKALIALALAQDTETIVLDEPTNHLDIRSQLEIIELLHKLHHEMKKTIVLVIHDINNGLKYAHKVMIMKNGEMVRYGKLKETIDHEILLDVFGVESIIVKNESTYPQVSVTDFSLPKDYKINEIKENEKTNSIYNDGDEVEIENELEKEVDKTKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ61</accession>
    <name>Y427_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU427</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU427</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891768.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ61"/>
    <dbReference type="SMR" id="Q9PQ61"/>
    <dbReference type="STRING" id="273119.UU427"/>
    <dbReference type="EnsemblBacteria" id="AAF30839">
        <property type="protein sequence ID" value="AAF30839"/>
        <property type="gene ID" value="UU427"/>
    </dbReference>
    <dbReference type="GeneID" id="29672293"/>
    <dbReference type="KEGG" id="uur:UU427"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.443"/>
    <dbReference type="eggNOG" id="COG1528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1569986_0_0_14"/>
    <dbReference type="OMA" id="YNVELCA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000135069" description="Uncharacterized protein UU427">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00085"/>
        </source>
    </evidence>
    <sequence length="170" mass="19884" checksum="EE5DA7DCCBB6723E" modified="2000-12-01" version="1">MVKSQKVIDVLNTHYNLNLELGSIYAQYAHIADDQFSMPFLAKFIADLSNDKLGVHKNLISEYARKVEIPLHTKFSVDVNFKPANPKELIKHILDTELKVRKHVANMAKVCLEENDFETFSFVKWFVDDGIKDFDDVRTIHDFFENATNNLQVEYAIRKYLKQMKVEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ70</accession>
    <name>Q9PQ70_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891763.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU419"/>
    <dbReference type="EnsemblBacteria" id="AAF30830">
        <property type="protein sequence ID" value="AAF30830"/>
        <property type="gene ID" value="UU419"/>
    </dbReference>
    <dbReference type="GeneID" id="29672610"/>
    <dbReference type="KEGG" id="uur:UU419"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.435"/>
    <dbReference type="eggNOG" id="COG5377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084220_0_0_14"/>
    <dbReference type="OMA" id="NWIRFGF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="288" mass="33732" checksum="93357730A8BB01B2" modified="2000-10-01" version="1">MPFIKTPNKDFGLVDNQIVLSSDYKKRYQRYFAKITGSRLGSILNIGDFTNPVRTWAMMVKIYNEPIDPIYAQAGVVIEPKIKDYVETVLKVKYKQYEPAQIGYDVFKDNQIFGGIPDGEPIDENGQLLYPNQPMLEIKTTSIDSFSFKTIDYVLVLQKDEHNHPIIKKKGDKRAKWFNNDESEVIISDEYQLQLGLYCYLRKISKGIFAIAFLTSEDYINPQAFDINKNEIILVNYELDLNEFEKVISKAKTWYEEYIIKGISPKLTKEDLEWYKVWINKYETNNLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-27" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ97</accession>
    <name>ACPS_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="1">Holo-ACP synthase</shortName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpS</name>
        <name type="ordered locus">UU393</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688628.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ97"/>
    <dbReference type="SMR" id="Q9PQ97"/>
    <dbReference type="STRING" id="273119.UU393"/>
    <dbReference type="EnsemblBacteria" id="AAF30803">
        <property type="protein sequence ID" value="AAF30803"/>
        <property type="gene ID" value="UU393"/>
    </dbReference>
    <dbReference type="GeneID" id="29672660"/>
    <dbReference type="KEGG" id="uur:UU393"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_1_1_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175725" description="Holo-[acyl-carrier-protein] synthase">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <sequence length="115" mass="13507" checksum="D4556906F9116271" modified="2000-10-01" version="1">MKLVHGIDIIEWNREELNNPLFAKRILIDNELEYYFQLNSSREKKRYLASVFACKEAVMKALKLKYGYGDILILKTENQRQVYLNKILIKELELSISYTETYIVASVVGLINNMN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-28" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA7</accession>
    <name>DER_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">der</name>
        <name type="synonym">engA</name>
        <name type="ordered locus">UU383</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688696.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQA7"/>
    <dbReference type="SMR" id="Q9PQA7"/>
    <dbReference type="STRING" id="273119.UU383"/>
    <dbReference type="EnsemblBacteria" id="AAF30793">
        <property type="protein sequence ID" value="AAF30793"/>
        <property type="gene ID" value="UU383"/>
    </dbReference>
    <dbReference type="GeneID" id="29672164"/>
    <dbReference type="KEGG" id="uur:UU383"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_14"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000179067" description="GTPase Der">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 1">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 2">
        <location>
            <begin position="175"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="KH-like" evidence="1">
        <location>
            <begin position="352"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <sequence length="442" mass="50547" checksum="11D7C67C92902932" modified="2000-10-01" version="1">MRTIAIVGKPNVGKSSLFNRILMRRKSIVDDQPGVTRDRIYDIGNWLTRSFMLIDTGGIISSKDTYQDNINEQVLFAINEANTIIFLVSAKDGINNDDKKIAKMLKEKAKDKKIILVINKIESEKYYLNEGELYSFGFGKFFKISAEHGIGMGDLLDELVKDMPIQNNLEKQERFKFCIIGRPNVGKSSLTNTILGEQRVIVNAEAGSTRDSIDNDFNYYNKKYTIIDTAGIRRKGKIVESVEKYAVLRTKKAIERSQLILLVLDGSEPFKEQDEVVGGLAYNANIPTIIIVNKWDNIINKNSHTMEMVKKQIRSQFKYLSWAPIVFVSALDNKRIHTIFEAIEFVREQAMRKIATSLLNDVVIKANAFQEPPPFKGGRISISYIVQVQSQIPTFVLKCNNPKFLHFSYARYIENEIRKAFGFDSVPITLYWQDKNKKLRGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB5</accession>
    <name>Y376_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU376</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU376</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">To U.parvum UU171.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQB5"/>
    <dbReference type="EnsemblBacteria" id="AAF30785">
        <property type="protein sequence ID" value="AAF30785"/>
        <property type="gene ID" value="UU376"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU376"/>
    <dbReference type="HOGENOM" id="CLU_069143_0_0_14"/>
    <dbReference type="OMA" id="AKLFMTF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220831" description="Uncharacterized protein UU376">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="242" mass="26940" checksum="922B9706522B2541" modified="2000-10-01" version="1">MNFEAASAPSQQPSPTPAPKTEEPKENGGSEQQADQPENSKKDDVVASGVKISEVKNNTATIEVTFSKFELADANKKDFVLEVIKKADTNPIQASDLKYDEASKTLSGKLSGLNSNVDYEISKLTLNGKEVKFNEEELLKSYVKNAKLFMTFNKENKKINVKLQNFDILNSLEENQPILTFDIEIKKDSSLQVVHKSLTKNQLSNLNGLEIDLKDKMNGNNANYDVKLTNAKLLNVNIETQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC9</accession>
    <name>Q9PQC9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADP-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gapN</name>
        <name evidence="6" type="ordered locus">UU362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689143.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU362"/>
    <dbReference type="EnsemblBacteria" id="AAF30771">
        <property type="protein sequence ID" value="AAF30771"/>
        <property type="gene ID" value="UU362"/>
    </dbReference>
    <dbReference type="GeneID" id="29672571"/>
    <dbReference type="KEGG" id="uur:UU362"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.376"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_14"/>
    <dbReference type="OMA" id="PMPIAAW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="13"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="475" mass="52591" checksum="DDB0D06576603752" modified="2000-10-01" version="1">MNYKTLINGAFVDAKEKLPVYNPSNNQIIAYVPNIHNENEINTIFENAHIAYLKFKDTPIKYRCDLLLKLADKLDEHKQELAQIISTEIAKGLKDSLIEVERSADYLRETVFEYQKLMQKPIIFDETVHHVKNKVATYYRIPVGVVLAICPFNYPINLLISKLAPALVSGNSLVYKPSTQGSLIGIRISELVHEVGFPKGVVNCLTTEARITGDLLVTNKYVKAISFTGGPKVGNHIAEITSKISLVLELGGKDPALVLDDADFELAANEIVKGAYGFSGQRCTAIKRVFVSHKNHDLLVNLINKKVDALTVGLPQQNPIITPLINSNSLKYNLSLVEDAIKKGAIVHQKIVYNEKNNLLHPLVIDNVTKEMRVAWEEPFGPILPIITYNSIQEAIDLINQSQYGLQACIFTTNYASIEQLALQIESGTININKSSSRGPDILPFFGVKDSGFGVQGIVDAILSMTTIKGIIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD3</accession>
    <name>Q9PQD3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrichrome ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fatC-2</name>
        <name evidence="8" type="ordered locus">UU358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688598.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU358"/>
    <dbReference type="EnsemblBacteria" id="AAF30767">
        <property type="protein sequence ID" value="AAF30767"/>
        <property type="gene ID" value="UU358"/>
    </dbReference>
    <dbReference type="GeneID" id="29672422"/>
    <dbReference type="KEGG" id="uur:UU358"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.372"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064507_0_0_14"/>
    <dbReference type="OMA" id="LYMLIQT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="367" mass="41360" checksum="5B4E9614E0619231" modified="2000-10-01" version="1">MKNPSRFIFIIKNNILNTINNASFIENGNFKKKFRVYARKQHLAAWVISIVTILFLSLLVMFIKINNQGQLLNNRTPLDLFKVNYETILQIWITGASLGASAYMFQRITKNRLVDTSTLGIGNVCLIGLFFLAISINFENYGSQKLFENLLPFIFIISGVCAGLILYWFSKKRTGFSHTKLIVSGVFINFIAIALSISLKDNLTLVASNYIDDRLLGNFSNRNSTEKYLSYAVFLFLMIWCFLRSAKFKVVITDTMIAEQLGLKVKLLNLEMIFISSCLTAVSYIMGGNVLFLGIAAANLGYAVFGNRFSSSIIFSSFITIIFLIFGQFILDNIVQNLTSLVFDAPIVTPLLVAPIFTFIILFKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE2</accession>
    <name>Q9PQE2_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoD</name>
        <name evidence="5" type="synonym">sigA</name>
        <name evidence="7" type="ordered locus">UU349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891740.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU349"/>
    <dbReference type="EnsemblBacteria" id="AAF30758">
        <property type="protein sequence ID" value="AAF30758"/>
        <property type="gene ID" value="UU349"/>
    </dbReference>
    <dbReference type="GeneID" id="29672383"/>
    <dbReference type="KEGG" id="uur:UU349"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.363"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_3_14"/>
    <dbReference type="OMA" id="YQRWLAE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="197"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="448" mass="51387" checksum="664766CC4155620A" modified="2000-10-01" version="1">MSTKQNEPLFVNLEDLKQKVKLSFTEEFSFSYALSELEAGIFESRNLKGADAGDPEEILLNVVLDVSKKKRSRNEIKFNKLQNYFIHMNLREEHFSEIIDVLEAIGIRVPDYDLVMQSKSKTNTKKKDEYGIDDTLEISTSKIGFSSTTTEKVDDGIKAYLGVLGESKMLRSDEETEYAKMVISDDPSLVKIGKNQLYTSNMRLVTSIAKKYLNRGLDLEDLIQEGSSGLLKAIDKFDHEKGHKFSTYATWWIRQSITRAIADQARQIRIPVHMVETINKLTKAERNLIQELGRDPTAEEIAQAMNKVSQAKNQKEQLITAQKVVEIKKLNVDPVSLDKQIGHDEESQFSDFISDDEIISPEKYTEKKALNDQINEMFEKVLNDNEQRVIKMRYGLLPFERPYTLEEVGEYLGVTRERARQIESKAIRKLKHPSKTAKLRSFIGESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE3</accession>
    <name>Q9PQE3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Lon protease</fullName>
            <ecNumber evidence="6 7">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 14" type="primary">lon</name>
        <name evidence="14" type="ordered locus">UU348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="6 7"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891739.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q9PQE3"/>
    <dbReference type="STRING" id="273119.UU348"/>
    <dbReference type="MEROPS" id="S16.004"/>
    <dbReference type="EnsemblBacteria" id="AAF30757">
        <property type="protein sequence ID" value="AAF30757"/>
        <property type="gene ID" value="UU348"/>
    </dbReference>
    <dbReference type="GeneID" id="29672351"/>
    <dbReference type="KEGG" id="uur:UU348"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.362"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_14"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="605"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAF30757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="791" mass="89527" checksum="1980DA438D593E00" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE4</accession>
    <name>TIG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Trigger factor</fullName>
            <shortName>TF</shortName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tig</name>
        <name type="ordered locus">UU347</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689135.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQE4"/>
    <dbReference type="SMR" id="Q9PQE4"/>
    <dbReference type="STRING" id="273119.UU347"/>
    <dbReference type="EnsemblBacteria" id="AAF30756">
        <property type="protein sequence ID" value="AAF30756"/>
        <property type="gene ID" value="UU347"/>
    </dbReference>
    <dbReference type="GeneID" id="29672387"/>
    <dbReference type="KEGG" id="uur:UU347"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_2_14"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000179456" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type">
        <location>
            <begin position="172"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="449" mass="51466" checksum="DEB75DE94E028C73" modified="2000-10-01" version="1">MKLLNKIKNENAIEFQILIEKSEWEKKHKESFEKIAKKTASKLKIPGFRPGKVPVEEAKKHVNEIEVFETTTNDLIPQVLTFLEQDESFINDDSETVDTPSVDILDFKDGELSLKVVYDLYPVATIESYNDLILTPIVNEAFEHEVNAEIEHALNSKSQRRVKDDNEFIEKGDEVRFDFKGMIDSVPFEGGSAKDHLLTIGSNQFIPGFEDQMIGLKKDERKNINVKFPDDYHATDLAGKAAVFEVFIKEITNVKPQELNDEFAKSFNLPNVNTVQELKDYIHNQIVLAKQEKNSERAWLEIAQQLLAKAKITPIPQSLIDREVSTLRQQVLSQLSQYKIELKQYLEFSKKSEAQFQEDLIRQAKETITLALLVDDIAETQNIVVSDEEVKERVAEMAKLYQGEEQAVIEQLSKNPDAVKEFLLHKKVVNYLIDLNKNNQPKNTTLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF0</accession>
    <name>Q9PQF0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU341"/>
    <dbReference type="EnsemblBacteria" id="AAF30750">
        <property type="protein sequence ID" value="AAF30750"/>
        <property type="gene ID" value="UU341"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU341"/>
    <dbReference type="HOGENOM" id="CLU_1433922_0_0_14"/>
    <dbReference type="OMA" id="WINFKEI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="191" mass="22683" checksum="E46361C1ADFE44B9" modified="2000-10-01" version="1">MIDRKQIHVKTRLTINELNKFYTLIRVQKQSLKEIEDKIKKLDWINFSEIKNQNLFDEFKFDYKNMTPYVISQVQDLVSVYDVRQISEIILELNQVNIQIQTKDSEFYIKNNKKLSLISSEFEDYQLKNYDAYEHFKITMDEPKIHTLNHQMPFDSKLNIKTIIFIVLTSCLLCLLIVIIICALLIAGVIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-06-20" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH6</accession>
    <name>IPYR_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="1">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppa</name>
        <name type="ordered locus">UU315</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688700.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQH6"/>
    <dbReference type="SMR" id="Q9PQH6"/>
    <dbReference type="STRING" id="273119.UU315"/>
    <dbReference type="EnsemblBacteria" id="AAF30724">
        <property type="protein sequence ID" value="AAF30724"/>
        <property type="gene ID" value="UU315"/>
    </dbReference>
    <dbReference type="GeneID" id="29672502"/>
    <dbReference type="KEGG" id="uur:UU315"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_2_14"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137536" description="Inorganic pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <sequence length="181" mass="21311" checksum="990409196CEBBC2C" modified="2000-10-01" version="1">MKLNVTIEIPKNSNIKYEYDRATKEIMVDRILHGSMVYPHNYGFLKEALDYDGDELDVLVFADQAFQPGIKVPARVLGAMKMIDGGETDTKLLAVIDVDPRYKHINNFKDIPLHWLAEVQDFFENYKNLQNKKVKILGFEDEIWAQKEYEECVLLMKEYGHLKKDEFVTKMMKERPEKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI2</accession>
    <name>Q9PQI2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688579.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30718">
        <property type="protein sequence ID" value="AAF30718"/>
        <property type="gene ID" value="UU309"/>
    </dbReference>
    <dbReference type="GeneID" id="29672479"/>
    <dbReference type="KEGG" id="uur:UU309"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.322"/>
    <dbReference type="HOGENOM" id="CLU_1453827_0_0_14"/>
    <dbReference type="OMA" id="QIFFLAS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="186" mass="22757" checksum="413451316FB3FB2E" modified="2000-10-01" version="1">MFEQVFFLASINDKKIIRWLYERYHKIFLKYINEQLNFKFYTLEIEANDLKTIIYEIFLKIFQVTRIKSLNQFIGFVKRQIYFYLVYLLRKSLSNKNLVNHLNNNNFENYELISTNSDEVGAELNNRFLIYEFLRSIQKENLFLYHFTILIIKGYNTKEISEILKINSAKIYYYKALLKKYIKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI3</accession>
    <name>Q9PQI3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688561.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU308"/>
    <dbReference type="EnsemblBacteria" id="AAF30717">
        <property type="protein sequence ID" value="AAF30717"/>
        <property type="gene ID" value="UU308"/>
    </dbReference>
    <dbReference type="GeneID" id="29672435"/>
    <dbReference type="KEGG" id="uur:UU308"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.321"/>
    <dbReference type="eggNOG" id="COG3611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729459_0_0_14"/>
    <dbReference type="OMA" id="MISHAYG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="381" mass="45365" checksum="EF4869879CEBE5FA" modified="2000-10-01" version="1">MDIVIKKNCNFVKNDDHLYSFYTPLIGMQAVALYSWFVNRENIFNKKGTINLTHEYLLDELNISINTYNELITKLINVDLIKIYSFENNSQQVIEVFRPLKFSEFINIEKFNEELKNNVSLNHYNVLNLLNKENNIDTNRLIDLSAQFKTNHFNNLENKLDKIKKIILKEYGLSLQIDESTKLCLINFFKKYKFSIDQMLNLIKNNLINNIDFLTIDLNKLELTIFSNMEFEKNKTKFQYYNIERDFNIFNKNSNLDRFKNVINDYNNFKPSDFLKHIRKEKLSLKDKEAINLLTYDKSLSDPIVNVILDFVLFKNLGRLNVKYLKRIKETVLGINIKDEYEMIKFFQNKKNDHKELICEDSDNANTFKNTNFIEVKFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI6</accession>
    <name>Q9PQI6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688671.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU305"/>
    <dbReference type="EnsemblBacteria" id="AAF30714">
        <property type="protein sequence ID" value="AAF30714"/>
        <property type="gene ID" value="UU305"/>
    </dbReference>
    <dbReference type="GeneID" id="29672467"/>
    <dbReference type="KEGG" id="uur:UU305"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.318"/>
    <dbReference type="eggNOG" id="COG4123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061983_3_2_14"/>
    <dbReference type="OMA" id="GLLCARD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="255" mass="30206" checksum="1551BB9EA6B3861B" modified="2000-10-01" version="1">MQKKYIKNTLGFDTNLFIYQDKKMFNYSIDTILLANFISLSSKTKKILEIGTNNAALSIFLALRKEDIKIDAIEIQIEAINLALLNVSQNHFEKQINIIHADFNQYWKDFDKSENNKYDAIICNPPFYKQDKIIPSTKNPLKTLALYEITLNFEQIMQGCAKIIKQKGNLAMVIPTTRLVDLLEIMRKYQFEPKRIKMIYPRIYEQSNLVLIEARYKSGWGTHFEPNLYLHYEDKQNHQYTEEVLNWYKPIKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL0</accession>
    <name>Q9PQL0_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deoD</name>
        <name evidence="6" type="ordered locus">UU281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688887.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU281"/>
    <dbReference type="EnsemblBacteria" id="AAF30690">
        <property type="protein sequence ID" value="AAF30690"/>
        <property type="gene ID" value="UU281"/>
    </dbReference>
    <dbReference type="GeneID" id="29672480"/>
    <dbReference type="KEGG" id="uur:UU281"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.291"/>
    <dbReference type="eggNOG" id="COG0813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_2_0_14"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="14"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="239" mass="26271" checksum="622FBD738AF81BD9" modified="2000-10-01" version="1">MTAHNQAKLGEIAKVVLMPGDPMRAKWIAETFLENAILVNEVRGMLCYTGTYKGKKISIMGHGMGIPSIGIYSYELYKFYEVETIIRVGSTGSYKKDLNVNDVVLVEKSYSDSTFASLIGAQVGDDKVLLPSREVNNLIKNTAKELNLELSLATCHASDVFYNNDFQTLDEIIHRTKSDCVDMESFGLFANAQILNKNAATLLTVSDSLITGDALSPAERANTFKKMVTLALESAIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL1</accession>
    <name>Q9PQL1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endo-1,4-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">celM</name>
        <name evidence="9" type="ordered locus">UU280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688850.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU280"/>
    <dbReference type="EnsemblBacteria" id="AAF30689">
        <property type="protein sequence ID" value="AAF30689"/>
        <property type="gene ID" value="UU280"/>
    </dbReference>
    <dbReference type="GeneID" id="29672534"/>
    <dbReference type="KEGG" id="uur:UU280"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.290"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_0_0_14"/>
    <dbReference type="OMA" id="FGWPAIH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="363" mass="40304" checksum="D53056C4ED25ECEC" modified="2000-10-01" version="1">MSKFNEKEIRNKAIEYMEIYGMSRHEERVASKLKASLKDAGVDYERDNLGSIIFKKTNSNKGPKILIATHMDEVGFVVQQILDNGQLLLSMVGGVWPNIAIGSVAKVYVDEQRQYTGVFGHTSIHILEPEARSKAVPVKELFVDCGFNSKQQAIDLGIEIGTEVYMEGPTLNFYDENYIVGKAVDNRVSVAVLDLLIHSLKDKVIPNQTYFAATVQEEVGLRGAKTVVSKVKPDIGIVIDTTTSHDTYKCPEGDTKLNDGVCIRIKDGGTLVNPKLVKYFEELAIKHNIPLYKYVARGGGTDAEELQYGPNGGVLTIGLSIPQRYLHAPIGVATVKDIKAAFDLVREFLEVFDENEFEKVKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM1</accession>
    <name>Q9PQM1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688847.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU270"/>
    <dbReference type="EnsemblBacteria" id="AAF30679">
        <property type="protein sequence ID" value="AAF30679"/>
        <property type="gene ID" value="UU270"/>
    </dbReference>
    <dbReference type="GeneID" id="29672616"/>
    <dbReference type="KEGG" id="uur:UU270"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.279"/>
    <dbReference type="HOGENOM" id="CLU_1239699_0_0_14"/>
    <dbReference type="OMA" id="MAINFGL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="223" mass="25968" checksum="6A7988CF389E6BBB" modified="2000-10-01" version="1">MINKNKKFHFQYFKKDNDQSISTKETLKRYFNFRSQSVKLIIFNLVLTAFFLALFLIGRFLTKNLDFLNGFSWQLQMGIFVLAIVCIPNFYYKLMYYIIAPLVMLAIGFSAEPFFGYLMPHYGFGLILFTDVILIIVKKSCQSIKKQIFLSYLLIFSFSIIGYFIVWMGYSIQGTLFYNTAFIPSMIYNSLVTFGSMAINFVLYIISIPAIVALKNKYLCKLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN4</accession>
    <name>RPOA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">UU257</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004027516.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQN4"/>
    <dbReference type="SMR" id="Q9PQN4"/>
    <dbReference type="STRING" id="273119.UU257"/>
    <dbReference type="EnsemblBacteria" id="AAF30666">
        <property type="protein sequence ID" value="AAF30666"/>
        <property type="gene ID" value="UU257"/>
    </dbReference>
    <dbReference type="GeneID" id="29672475"/>
    <dbReference type="KEGG" id="uur:UU257"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_14"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175415" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="259"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <sequence length="327" mass="36817" checksum="4BAEC583237902E4" modified="2000-10-01" version="1">MRKFLKYQLDVPSINSEDKNRTVVKIAPLEIGFGDTLGNALRRICLSSIPGASMFAVKFGGYSHEFQPYEGVKEDITHIILNLKNLAIKIDELIYSEDYFNNLLIDKWPKMKINFKGPGVITAKDIVCPVGFEIVNQDLYIAEVTKPIDVEIEIFAKTGRGRVDFNTNKDFVSTLHIIATDSNYSPVLHYAYNVEMIKDSKSSMSEILTIDIATNGTISGSEAIAIAAKIMQAHLEPIVNIDKTINEMIIMREREEEEKRQNASISIDDLDLTVRAYNALKQSGINTTAELIELTKSQLEKIKNLGRKSVTEIIQKLTERSLELKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP5</accession>
    <name>Q9PQP5_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpL6</name>
        <name evidence="6" type="ordered locus">UU246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688947.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU246"/>
    <dbReference type="EnsemblBacteria" id="AAF30655">
        <property type="protein sequence ID" value="AAF30655"/>
        <property type="gene ID" value="UU246"/>
    </dbReference>
    <dbReference type="GeneID" id="29672613"/>
    <dbReference type="KEGG" id="uur:UU246"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.255"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_14"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="5">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="5">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="182" mass="19480" checksum="4544659010544EC5" modified="2000-10-01" version="1">MSRIGNRKLTIPANVNVSVESGKVHIVSQTAKLSVDFPVNLISVDVVDNTVKVSRANDEKQTKMFHGTVNANIANALVGVTTGWKKELEVKGVGFRAKVEGSKLNLGLGFSHPLLIQIPTGLKVETPSATEISINGADKAAVGAFAAVVRAYRKPEPYKGKGVMYKGERIVRKAGKTADKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ2</accession>
    <name>RL29_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmC</name>
        <name type="synonym">rpl29</name>
        <name type="ordered locus">UU239</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026203.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ2"/>
    <dbReference type="SMR" id="Q9PQQ2"/>
    <dbReference type="STRING" id="273119.UU239"/>
    <dbReference type="EnsemblBacteria" id="AAF30648">
        <property type="protein sequence ID" value="AAF30648"/>
        <property type="gene ID" value="UU239"/>
    </dbReference>
    <dbReference type="GeneID" id="45015783"/>
    <dbReference type="KEGG" id="uur:UU239"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_2_0_14"/>
    <dbReference type="OMA" id="LKEMLFK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000130490" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="75" mass="8513" checksum="B358444E19459675" modified="2000-10-01" version="1">MSSIAQDLRKKDSLELEKIVIELKAKLLELRFAAANGEAEKLHTAKEIRKTIARALTILNERELAEKLNNKEANK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ7</accession>
    <name>RL2_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name evidence="1" type="synonym">rpl2</name>
        <name type="ordered locus">UU234</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025838.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ7"/>
    <dbReference type="SMR" id="Q9PQQ7"/>
    <dbReference type="STRING" id="273119.UU234"/>
    <dbReference type="EnsemblBacteria" id="AAF30643">
        <property type="protein sequence ID" value="AAF30643"/>
        <property type="gene ID" value="UU234"/>
    </dbReference>
    <dbReference type="GeneID" id="29672543"/>
    <dbReference type="KEGG" id="uur:UU234"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_14"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129646" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="279" mass="30873" checksum="83EF07E7B338B3D6" modified="2000-10-01" version="1">MAVKRIKNHSSGKRQTVVVDYKSILTTSKPEKSLLVTLPKKAGRNNQGKITIRHHGGGHKRKYRIIDFKRNKDNIYGTIKSIEYDPNRTSFISLVVYADGEKRYIIAPKGIKVGDKIISGNENIDILLGNSLPLEFIPEGTLVHNIELSPNAGGQITRSAGASAQILGFDETKKYILVKLNSGEVRKFRKECRATIGTVSNDEHILENLGKAGKSRHLGVRPTVRGSAMNPNDHPHGGGEGRSPVGMDAPRTPWGKRHMGVKTRNNKKSSTSMIVRRRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ9</accession>
    <name>RL4_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name evidence="1" type="synonym">rpl4</name>
        <name type="ordered locus">UU232</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688823.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ9"/>
    <dbReference type="SMR" id="Q9PQQ9"/>
    <dbReference type="STRING" id="273119.UU232"/>
    <dbReference type="EnsemblBacteria" id="AAF30641">
        <property type="protein sequence ID" value="AAF30641"/>
        <property type="gene ID" value="UU232"/>
    </dbReference>
    <dbReference type="GeneID" id="29672617"/>
    <dbReference type="KEGG" id="uur:UU232"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_14"/>
    <dbReference type="OMA" id="HVRINKK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129307" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="211" mass="23432" checksum="1B452E242549F8F6" modified="2000-10-01" version="1">MAKIKLLSIDGNFAKELEVTSDLFVEVPHKQAMFDSVLAENAAERQGTHSTLTKGEVRGGGKKPWRQKHTGKARTGSTRNPHWTGGGVVFGPKPNRNYNLKVNAKVRLLAFKSALTIKLNEGKMLGLVANSDLETPSTKKMVNFINNANLENQKVLLVIVDNFSNIKKSTNNLQKVTTKLWYQVSVRDLMHANVVVVAEEAFTNYARKVSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-13" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR1</accession>
    <name>RS10_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsJ</name>
        <name evidence="1" type="synonym">rps10</name>
        <name type="ordered locus">UU230</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025692.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQR1"/>
    <dbReference type="SMR" id="Q9PQR1"/>
    <dbReference type="STRING" id="273119.UU230"/>
    <dbReference type="EnsemblBacteria" id="AAF30639">
        <property type="protein sequence ID" value="AAF30639"/>
        <property type="gene ID" value="UU230"/>
    </dbReference>
    <dbReference type="GeneID" id="29672653"/>
    <dbReference type="KEGG" id="uur:UU230"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_14"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000146628" description="30S ribosomal protein S10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <sequence length="101" mass="11778" checksum="087D3E30D5810D9C" modified="2000-10-01" version="1">MNQELRIRLESYDHRLLDDTVKTIVNISNSTGSKLRGPIPLPTKKEIFTILRSPHVNKSSREQFERRTHKRLIILENPQPKTMEALKRLSVPFGVEVTFKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR2</accession>
    <name>RL20_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplT</name>
        <name evidence="1" type="synonym">rpl20</name>
        <name type="ordered locus">UU229</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688834.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQR2"/>
    <dbReference type="SMR" id="Q9PQR2"/>
    <dbReference type="STRING" id="273119.UU229"/>
    <dbReference type="EnsemblBacteria" id="AAF30638">
        <property type="protein sequence ID" value="AAF30638"/>
        <property type="gene ID" value="UU229"/>
    </dbReference>
    <dbReference type="GeneID" id="29672663"/>
    <dbReference type="KEGG" id="uur:UU229"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_14"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000177256" description="50S ribosomal protein L20">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <sequence length="120" mass="14097" checksum="48B857D29597E8E2" modified="2000-10-01" version="1">MRVKGGSVTRQRRKRWLEKAEGSWGTRNTSYRIARQTVIRAAEYAYRDRRNKKRDFRKLWISRINAAVRELGYTYSQFMNALVKANVVTKDGQGLNRKMLSELAINNPEAFNQLVDKVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR6</accession>
    <name>Q9PQR6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU225.1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU225.1"/>
    <dbReference type="EnsemblBacteria" id="AAF30634">
        <property type="protein sequence ID" value="AAF30634"/>
        <property type="gene ID" value="UU225.1"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU225.1"/>
    <dbReference type="HOGENOM" id="CLU_148089_0_0_14"/>
    <dbReference type="OMA" id="AWAMYNA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="112" mass="12559" checksum="8D65AB931C85803A" modified="2000-10-01" version="1">MHLGIYYMVYSYYGSPYLTQDIATTNVVNAWAMYNAGVAFLVIFALIEIASFALFVTTTVNVGLNLKRQENFVLPFVFGILGCLGIIPIIGSIIIYVQLNKFYKQQNESSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR8</accession>
    <name>Q9PQR8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688888.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU224"/>
    <dbReference type="EnsemblBacteria" id="AAF30632">
        <property type="protein sequence ID" value="AAF30632"/>
        <property type="gene ID" value="UU224"/>
    </dbReference>
    <dbReference type="GeneID" id="29672680"/>
    <dbReference type="KEGG" id="uur:UU224"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.232"/>
    <dbReference type="HOGENOM" id="CLU_723492_0_0_14"/>
    <dbReference type="OMA" id="TIKEFNF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331071" evidence="1">
        <location>
            <begin position="28"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="382" mass="43248" checksum="88B6900D2DE39911" modified="2000-10-01" version="1">MKKNHKKWLLMTTPILLIGGLSTLALTSCKDGKKSNPKPDKPSTIEEYKLSLSSVETGFNEAKLIFDNNDSFKTLDNFKVILKNTQNTNEVIEASNLSATIENQKLVLKLNNLQDGQTYKINKILYQTNKEVILSNNQVFTTKTKPKIEYEVQEKILKLDDKTYYVVLKVKDPQNLNEPTKEILKSVTFTSKISNVANLKNAILENQRPYVKEDYSEIQIKLPRVPVISEKIEITANNSLFKSFTITVGEKHIKNVEKIIDITKKVFGNQELKSISITKQNSSSANITLSLKLNGNSIIVGANKLINKKDKAIKFSFFVKNKATNTVKEFNFNEKSKPIGSYQFTLNGLDANSDFVIEDIRYDDKSIKITEELLASLSFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS7</accession>
    <name>Q9PQS7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ptc1</name>
        <name evidence="2" type="ordered locus">UU215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688864.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU215"/>
    <dbReference type="EnsemblBacteria" id="AAF30623">
        <property type="protein sequence ID" value="AAF30623"/>
        <property type="gene ID" value="UU215"/>
    </dbReference>
    <dbReference type="GeneID" id="29672700"/>
    <dbReference type="KEGG" id="uur:UU215"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.223"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_4_1_14"/>
    <dbReference type="OMA" id="MLNAQFF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="247" mass="28322" checksum="A81EFE16AF275C80" modified="2000-10-01" version="1">MNFGFISDIGSQRKHNDDCALVIQNQYQQTLLIVCDGLGGYKGGAAASHITLETIKDNFLTTDFSEYDKQQIQKWYIKVIKLAQVEIDRTVLLDKDVYNMGTTVVASIVVNDFSYTLNIGDSRAYLLSNEQFLQISRDHNLLQVLQERKANPEVYKKHEKNLFSLTQFVGRTSNIFLSYDLFVNKLNPNEIIVLTSDGFHNYFELNTLYEKLIKSTQETKNELLQQLIRQAIINGSNDNLSLAFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT1</accession>
    <name>Q9PQT1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688952.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU211"/>
    <dbReference type="EnsemblBacteria" id="AAF30619">
        <property type="protein sequence ID" value="AAF30619"/>
        <property type="gene ID" value="UU211"/>
    </dbReference>
    <dbReference type="GeneID" id="29672657"/>
    <dbReference type="KEGG" id="uur:UU211"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.219"/>
    <dbReference type="eggNOG" id="COG2868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140910_1_0_14"/>
    <dbReference type="OMA" id="HANSDEY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16332">
        <property type="entry name" value="Prp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007422">
        <property type="entry name" value="Peptidase_Prp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036764">
        <property type="entry name" value="Peptidase_Prp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04327">
        <property type="entry name" value="Peptidase_Prp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118010">
        <property type="entry name" value="SSF118010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="102" mass="12004" checksum="EC3EB0F245BB33BB" modified="2000-10-01" version="1">MIKINHYPNALLVKGHANFDEHGKDIVCAGVSAIIMGALNWFDQQKTTIKVEQGFILIIIDNNNQLYRQYLELIIIQLKAIYFKYQSYIELHEYKQQYKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT6</accession>
    <name>Q9PQT6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688935.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU207"/>
    <dbReference type="EnsemblBacteria" id="AAF30614">
        <property type="protein sequence ID" value="AAF30614"/>
        <property type="gene ID" value="UU207"/>
    </dbReference>
    <dbReference type="GeneID" id="29672647"/>
    <dbReference type="KEGG" id="uur:UU207"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.214"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017496_1_0_14"/>
    <dbReference type="OMA" id="TRTIPQG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="564" mass="64014" checksum="5C38D940382A2838" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-04-03" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT7</accession>
    <name>PLSX_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsX</name>
        <name type="ordered locus">UU206</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688948.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQT7"/>
    <dbReference type="SMR" id="Q9PQT7"/>
    <dbReference type="STRING" id="273119.UU206"/>
    <dbReference type="EnsemblBacteria" id="AAF30613">
        <property type="protein sequence ID" value="AAF30613"/>
        <property type="gene ID" value="UU206"/>
    </dbReference>
    <dbReference type="GeneID" id="29672706"/>
    <dbReference type="KEGG" id="uur:UU206"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_14"/>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189960" description="Phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <sequence length="331" mass="37118" checksum="830E4DDF9C747CF1" modified="2000-10-01" version="1">MEKIKILLDTMGYENDLEHVIKAAKDFYYQHEDDLEIILVGNEQLIKPLLDNDWRLFPIVHTEVSIEQNDTILSARKKQNSSMHLALRYLKDKQADGMLTAGNSAVFVYNAYATIGLLEHIKKPAFMPFVPTIDGGVTNLLDVGASIDVDGTDLFNFAIMANTIAKMRTPNPRVGVLNIGTEDHKGLPYHQEANELLKTSNLNYVGFVEPKTILEREVDVLVADGFSGNIALKTMEGVGKTISNFLKNEYKKPKNLFAALLSKPIFKKIKKAFDYKEHAGAFVLGLDGILVKTHGSADYQQFMSALKILYETIKADVLNEIKKDLNNYYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU4</accession>
    <name>Q9PQU4_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ordered locus">UU199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689125.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU199"/>
    <dbReference type="EnsemblBacteria" id="AAF30606">
        <property type="protein sequence ID" value="AAF30606"/>
        <property type="gene ID" value="UU199"/>
    </dbReference>
    <dbReference type="GeneID" id="29672614"/>
    <dbReference type="KEGG" id="uur:UU199"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.206"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023674_0_0_14"/>
    <dbReference type="OMA" id="INIALEM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="84"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="429"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="731" mass="82171" checksum="CFF79FA8B3EE193D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU7</accession>
    <name>Q9PQU7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688885.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU196"/>
    <dbReference type="EnsemblBacteria" id="AAF30603">
        <property type="protein sequence ID" value="AAF30603"/>
        <property type="gene ID" value="UU196"/>
    </dbReference>
    <dbReference type="GeneID" id="29672676"/>
    <dbReference type="KEGG" id="uur:UU196"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.203"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_1_2_14"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="408" mass="46830" checksum="8E8ED1147CF1026C" modified="2000-10-01" version="1">MLDKLIKTLKNPHSIDDIVGQKYLLDEIGIIRRMVNHHQVFNLIFYGPPGVGKSSLAKVLAQDLKVPFAFFNPVVDSKKQLMQIIEQALDLNNFIIIIDEIHRLNKDKQDILLPIIEANKIKLFATTTENPFFVINPALRSRCQLLSLKPLTSSQISERIKTLINVEEVFEPQAFNLLINKTNGDLRAVINTLEIIYLLYKEHKVDYVLLKRIMQESYALGSSDGDEIHDLKSAFHKSMRGSDCDAALYYLARLIIIGDFEAIYRRVSVCVHEDIGLANPNLCLRVDQGINSCRFLGYPENQVILANLVLQICLSNKSNSVYLAYQKAFEDAANGKQYSIPNHVRDAHYASAIKLGVHGYKYPHDFKNNYVNQQYLPRELTNKKYYVPQNNEQEFKLNQNQQKFKNNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW0</accession>
    <name>Y183_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU183</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU183</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688911.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW0"/>
    <dbReference type="SMR" id="Q9PQW0"/>
    <dbReference type="STRING" id="273119.UU183"/>
    <dbReference type="EnsemblBacteria" id="AAF30590">
        <property type="protein sequence ID" value="AAF30590"/>
        <property type="gene ID" value="UU183"/>
    </dbReference>
    <dbReference type="GeneID" id="29672644"/>
    <dbReference type="KEGG" id="uur:UU183"/>
    <dbReference type="HOGENOM" id="CLU_956277_0_0_14"/>
    <dbReference type="OMA" id="INNSYYA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220830" description="Uncharacterized protein UU183">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="291" mass="34342" checksum="19C9382DE6288358" modified="2000-10-01" version="1">MDKKAKIYTWSHIILIVFSLVCLHWFFILSITIPNQTGFLINRVGQWINSSSTYAYKIDPRSLFYLNYTLNFNIALNASGIASIVLFICYILTFIFNLIMIGIIRSWRPSLLHLIIAILIWLAILYLFIIIMIKPNFNQIINNSYYTWLKNVIFNDQTLTLNKKNVILNTYINHYHLPIINDPQVALLDISKHQINNENLTFNPSYNYNANLYFTKAKLIYCTYTIIGIIFIISFIYYLSEIIKRCLLVNDNWKIKQHERKDGLNIKKRKNKQEIVAPDPILEEIFKELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX4</accession>
    <name>Q9PQX4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026493.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU169"/>
    <dbReference type="EnsemblBacteria" id="AAF30576">
        <property type="protein sequence ID" value="AAF30576"/>
        <property type="gene ID" value="UU169"/>
    </dbReference>
    <dbReference type="GeneID" id="29672609"/>
    <dbReference type="KEGG" id="uur:UU169"/>
    <dbReference type="eggNOG" id="COG1783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567344_0_0_14"/>
    <dbReference type="OMA" id="QNPYYEY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006437">
        <property type="entry name" value="Phage_terminase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035421">
        <property type="entry name" value="Terminase_6C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17289">
        <property type="entry name" value="Terminase_6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01547">
        <property type="entry name" value="phage_term_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_6C" evidence="1">
        <location>
            <begin position="282"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="481" mass="55977" checksum="F1A1EA1A7E71E985" modified="2000-10-01" version="1">MRIKLDFIECFGFYSDLVEFVAKKLPIPFNEINLLGGRSSGKTFATLDFLSSLVAIKQQNAIYVFRQNISDAKKIFSDYLNFLDQKQLLKFAKINHSERTVIINGWTVMFEALNETRNNINKGAKVGFRLWTQARYVFAFFEEASQLDFNLVKNSQQSLRGTKDTQVVSIFASNPWTSEHWYIENFNNHLAENEFSIQQKPYYEYSVVDKKLFLRSTYRANKFTSQQEIEQFEWWKDIDYSKYRVISLGLSGSVEGAIYARSLSVMHEPYGEYDNYAMQFFGGMDWGDGTSSSSSDTACLFGSISKENGIEILDEMVYNNNVNPLTSEQQIELVVRWFIKKQQEVNVKIVIYIDNAHLRYFYETFNATFKRIAFQYNMYGSELVFAPAIKHAIWDRVVLVNYMLASGKLRFSKNACPKLYKDLKNCYVVLPKTIKEDTKKERSHEHTHTINALEYLMCAFHLYFYAQAPAINEKGAIRYGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY8</accession>
    <name>Y156_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU156</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU156</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891690.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQY8"/>
    <dbReference type="STRING" id="273119.UU156"/>
    <dbReference type="EnsemblBacteria" id="AAF30562">
        <property type="protein sequence ID" value="AAF30562"/>
        <property type="gene ID" value="UU156"/>
    </dbReference>
    <dbReference type="GeneID" id="29672236"/>
    <dbReference type="KEGG" id="uur:UU156"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.162"/>
    <dbReference type="HOGENOM" id="CLU_1712485_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220815" description="Uncharacterized protein UU156">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <sequence length="153" mass="18775" checksum="894C11DAFF37B7AC" modified="2000-10-01" version="1">MRSKQWHLSTQDANLANKKYDYIYFRGVNQLYLKRLKKSSNKFFVYKKCKIVPRMISKHLNNDHLINVNDYVPLTKEFIKKSVEKEVKHYLRFISYENKTKQMPELINFLEKSLEDKLFIVAKDYDPLFSVFLRYYIQSLIEKYINELWINEW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ3</accession>
    <name>Y151_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU151</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU151</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025899.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ3"/>
    <dbReference type="SMR" id="Q9PQZ3"/>
    <dbReference type="STRING" id="273119.UU151"/>
    <dbReference type="EnsemblBacteria" id="AAF30557">
        <property type="protein sequence ID" value="AAF30557"/>
        <property type="gene ID" value="UU151"/>
    </dbReference>
    <dbReference type="GeneID" id="45015949"/>
    <dbReference type="KEGG" id="uur:UU151"/>
    <dbReference type="HOGENOM" id="CLU_2940519_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220810" description="Uncharacterized protein UU151">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <sequence length="60" mass="7313" checksum="49AB0B55342E43F3" modified="2000-10-01" version="1">MKNQNEKQIKEYVNKFKDLRNQLTKNNDVKKVCDLINDLFFEVYKNNLIDEVIKEINKHD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ4</accession>
    <name>Y150_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU150</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ4"/>
    <dbReference type="STRING" id="273119.UU150"/>
    <dbReference type="EnsemblBacteria" id="AAF30556">
        <property type="protein sequence ID" value="AAF30556"/>
        <property type="gene ID" value="UU150"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU150"/>
    <dbReference type="HOGENOM" id="CLU_2703784_0_0_14"/>
    <dbReference type="OMA" id="ECQAIIN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220809" description="Uncharacterized protein UU150">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <sequence length="78" mass="9348" checksum="77C6AC9E2F55AA53" modified="2000-10-01" version="1">MAMLCMCDECQAIINYYVVQIEQLCNEIVKTRKRVEPYKKLGKLFFEIIQNDLFEAIAEEVFRIDEKPKRKTNKRVCK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ6</accession>
    <name>Y148_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU148</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU148</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025751.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ6"/>
    <dbReference type="STRING" id="273119.UU148"/>
    <dbReference type="EnsemblBacteria" id="AAF30554">
        <property type="protein sequence ID" value="AAF30554"/>
        <property type="gene ID" value="UU148"/>
    </dbReference>
    <dbReference type="GeneID" id="45015952"/>
    <dbReference type="KEGG" id="uur:UU148"/>
    <dbReference type="HOGENOM" id="CLU_2132439_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220807" description="Uncharacterized protein UU148">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <sequence length="113" mass="13269" checksum="5CDF46C519354F68" modified="2000-10-01" version="1">MDKIKNYLEKLQAFYKLYSLNLTQGTEILIIQIIDKGNLIFDSIEKGKTFNESKIIEPLLFIFKKINTILAILKLTFTKDDLIGILQSLEEHISEFIIANYKYDFEIEEDDED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ8</accession>
    <name>Y146_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU146</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU146</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025921.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ8"/>
    <dbReference type="STRING" id="273119.UU146"/>
    <dbReference type="EnsemblBacteria" id="AAF30552">
        <property type="protein sequence ID" value="AAF30552"/>
        <property type="gene ID" value="UU146"/>
    </dbReference>
    <dbReference type="GeneID" id="45015953"/>
    <dbReference type="KEGG" id="uur:UU146"/>
    <dbReference type="HOGENOM" id="CLU_1320412_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220805" description="Uncharacterized protein UU146">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <sequence length="208" mass="24772" checksum="A6B421CB52AE37BD" modified="2000-10-01" version="1">MINNIFNKKLLVYNEKDQRWYNKFDRTKPLFSPSRLLSFKNYIFEKIPAKNLEYPIEFGTSLMQIIQYYFENQSKLDVILNSINEEKLKEVFLLFLDYLKTNDYSLIAVELHLFSPKLNHYWHGFADVVVKTKDDKYKVLEIKTHNEIQSVPSWKFQAGVYDYIISQELSNYEPSAILAFSRKQAKLSVYENDSLDLSFINKINELYS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR02</accession>
    <name>Y142_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0122 protein UU142</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU142</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0122 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688941.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR02"/>
    <dbReference type="SMR" id="Q9PR02"/>
    <dbReference type="STRING" id="273119.UU142"/>
    <dbReference type="EnsemblBacteria" id="AAF30548">
        <property type="protein sequence ID" value="AAF30548"/>
        <property type="gene ID" value="UU142"/>
    </dbReference>
    <dbReference type="GeneID" id="29672731"/>
    <dbReference type="KEGG" id="uur:UU142"/>
    <dbReference type="eggNOG" id="COG2739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129218_1_2_14"/>
    <dbReference type="OMA" id="SIQEWQE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00245">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007394">
        <property type="entry name" value="UPF0122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40083">
        <property type="entry name" value="PTHR40083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04297">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211893" description="UPF0122 protein UU142">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="99" mass="11851" checksum="1EFA9F4694118594" modified="2000-10-01" version="1">MLNKNKRWYLIALYDIYQGLLTTKQCEYFNLHYFKDLSFSEIAELKEISKSAISDCLNKVCDQLLKYEQALLIYEKNKKRNDLYTLINDSELVKKLKDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR09</accession>
    <name>ATPF_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">F-type ATPase subunit b</fullName>
            <shortName evidence="2">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atpF</name>
        <name type="ordered locus">UU135</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR09"/>
    <dbReference type="SMR" id="Q9PR09"/>
    <dbReference type="STRING" id="273119.UU135"/>
    <dbReference type="EnsemblBacteria" id="AAF30541">
        <property type="protein sequence ID" value="AAF30541"/>
        <property type="gene ID" value="UU135"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU135"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_4_3_14"/>
    <dbReference type="OMA" id="FAWKPIL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000368852" description="ATP synthase subunit b">
        <location>
            <begin position="28"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <sequence length="205" mass="23216" checksum="8ED70551CE7B6AD2" modified="2000-10-01" version="1" precursor="true">MKLNKKHLVAILSVLSLSIIVVPLLTSCTGDIPELNPAEIINTLFPNVWVFIAQVIAMCVVFSLVLWLVWKPTNKMLDKRREYIAKEITDAENAKQEALQYLENAKSEHLAAQAQTLEIIAKAKSESLTLRESLEKEAREAADKIISSAKISIANERRENLERLQSEAREAAYIAAEALMKKELSREDNDKLVDQFIKELENNEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR10</accession>
    <name>ATPD_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit delta</fullName>
            <shortName evidence="1">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpH</name>
        <name type="ordered locus">UU134</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688889.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR10"/>
    <dbReference type="SMR" id="Q9PR10"/>
    <dbReference type="STRING" id="273119.UU134"/>
    <dbReference type="EnsemblBacteria" id="AAF30540">
        <property type="protein sequence ID" value="AAF30540"/>
        <property type="gene ID" value="UU134"/>
    </dbReference>
    <dbReference type="GeneID" id="29672294"/>
    <dbReference type="KEGG" id="uur:UU134"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_1_1_14"/>
    <dbReference type="OMA" id="NEYYNIA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000371188" description="ATP synthase subunit delta">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <sequence length="179" mass="20479" checksum="2D27F05C25988415" modified="2000-10-01" version="1">MKSSLKPVEKYAYSIFEIAKEEKKLDLYKHNLETINSIIEEVPAFFEAVGDPARDRNERKQIVIKNLEGEIDIYLISLIDLLIDVKSVKLLKKIVLKALDFVNEALSVKKVLITTAYELTKNQIDRLLQSLKKKYVCEKIEPIVVVDKSIIGGLSINFESQVLDNSLKTKLFNIVKKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR11</accession>
    <name>Q9PR11_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP synthase delta chain C-term</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH-1</name>
        <name evidence="6" type="ordered locus">UU133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688956.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU133"/>
    <dbReference type="EnsemblBacteria" id="AAF30539">
        <property type="protein sequence ID" value="AAF30539"/>
        <property type="gene ID" value="UU133"/>
    </dbReference>
    <dbReference type="GeneID" id="29672165"/>
    <dbReference type="KEGG" id="uur:UU133"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.139"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2319293_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="2" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="99" mass="11325" checksum="F0CC4B11BF8E894B" modified="2000-10-01" version="1">MQSNTKLAKYSKIIANRLKAYSNQTRFIEIKTAFELNDEQKQRIKKTVISRFGDERPIKFIVDPSLIGGISLKINLEIIDSSLKTKLNQIINTKEKEGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR12</accession>
    <name>ATPA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>ATP synthase subunit alpha</fullName>
            <ecNumber>7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpA</name>
        <name type="ordered locus">UU132</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689132.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR12"/>
    <dbReference type="SMR" id="Q9PR12"/>
    <dbReference type="STRING" id="273119.UU132"/>
    <dbReference type="EnsemblBacteria" id="AAF30538">
        <property type="protein sequence ID" value="AAF30538"/>
        <property type="gene ID" value="UU132"/>
    </dbReference>
    <dbReference type="GeneID" id="29672716"/>
    <dbReference type="KEGG" id="uur:UU132"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019180_0_0_14"/>
    <dbReference type="OMA" id="EDENHEY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000238393" description="ATP synthase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="ATP synthase alpha chain">
        <location>
            <begin position="1"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Unknown">
        <location>
            <begin position="550"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="799" mass="89447" checksum="1A63E0F5C8982C8B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR15</accession>
    <name>ATPB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit beta</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpD</name>
        <name type="ordered locus">UU129</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688878.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR15"/>
    <dbReference type="SMR" id="Q9PR15"/>
    <dbReference type="STRING" id="273119.UU129"/>
    <dbReference type="EnsemblBacteria" id="AAF30535">
        <property type="protein sequence ID" value="AAF30535"/>
        <property type="gene ID" value="UU129"/>
    </dbReference>
    <dbReference type="GeneID" id="29672255"/>
    <dbReference type="KEGG" id="uur:UU129"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_14"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000254419" description="ATP synthase subunit beta">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <sequence length="464" mass="50834" checksum="44ED390DBC2C04AA" modified="2000-10-01" version="1">MTEVKKGKINQILGPVVDVRFPSEWLPEINTALELNNHGSKLVLEVSQLVGDNIARCIAMDTTDGLVRGQEVINTQKPITMPVGKQVLGRMFNVTGDPIDEQPAPTGKRMPIHRPAPSFAEQAESIEILETGIKVVDLLVPFAKGGKIGLFGGAGVGKTVLMQELIHNIAKNHGGLSVFAGVGERTREGNDLYYEMAESDVLDKTALVFGQMNEPPGARMRVALSGLTMAEEFRDAFGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLAFEMGQLQERITSTKKGSITSVQAVYVPADDLTDPAPATTFSHLDAKVVLDRAIASLGLYPAISPLQSTSRLLDPLVVGVKHYSVARRVIEILQRFMELQDIIAILGMDELSEEDRQLVMRARKVRNYLSQPSHVAEKFSGQPGLSVKLEDTIEGFRKILDGECDDIHEQHFLYVGKIDDVFEKAAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR19</accession>
    <name>Q9PR19_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891681.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU125"/>
    <dbReference type="EnsemblBacteria" id="AAF30531">
        <property type="protein sequence ID" value="AAF30531"/>
        <property type="gene ID" value="UU125"/>
    </dbReference>
    <dbReference type="GeneID" id="29672136"/>
    <dbReference type="KEGG" id="uur:UU125"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.131"/>
    <dbReference type="HOGENOM" id="CLU_700091_0_0_14"/>
    <dbReference type="OMA" id="KDETEYQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331268" evidence="2">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="394" mass="46941" checksum="0C484DB37674D4FC" modified="2000-10-01" version="1">MKKNKYKLLIKSLVITSFLVTTSSVIVACTNKEKEQHLTELKKLSQHAKQIYNEIKTNELFKKEASVLNDQINKVLKINEQNNLDVITKNYNDLKKLLDEIQEKISKEKEKEKQQNAYLNKEINIKLENLNQIVNHNLLKGNKESFFNQIINFTPITTEIQTIINQNQNLLDFKNEELELKLKNLDLFIKELDHKFKNIIDQLFNIEDSYINKFLKFINNQDFIKDQKYQEREKFNPQEYLELTKSIQSSFNKLKNVTINSNLDQYLNSLNLVLLSLTNETKAFFTKFEDQIKKYFKWIVYGRDDTLTKAFNRIVEEQKRNEFIEQTEKALLTFPMEINQKFKMFVDFFTLKNDKNETEYQKIWKSKHNEVNKVWFGIAECFATGKCTDKNKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR26</accession>
    <name>Q9PR26_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ABC-1</name>
        <name evidence="6" type="ordered locus">UU118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688936.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU118"/>
    <dbReference type="EnsemblBacteria" id="AAF30524">
        <property type="protein sequence ID" value="AAF30524"/>
        <property type="gene ID" value="UU118"/>
    </dbReference>
    <dbReference type="GeneID" id="29672194"/>
    <dbReference type="KEGG" id="uur:UU118"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.124"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_14"/>
    <dbReference type="OMA" id="VLATHEM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="65"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="300" mass="34096" checksum="2E8E0C3E87E7551A" modified="2000-10-01" version="1">MRNKKENDNVINPLSNPDENKKINIKDLSKDERKELKKRIKEVEKLNRNHKGDIDMPSRDPNNIIELRDVKKIFTNGYLINETLKGVNLDIRKGEFVIILGPSGSGKTTLMNIMSGLDRATDGDVRVCDKQLINMNQNKLTDFRKEYIGFVFQQYGLLPTLSVEENVEIGADLQVDKKRRIKPQDALKAVGMLDYAKKFPHELSGGQQQRVSIARALAKNPIILFGDEPTGAVDETMSKIILKEFVKVNQELKTTVIIVTHNPIFAELGTLVIKVKDGNINELIRNDHPKSVDELKWDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR29</accession>
    <name>Q9PR29_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gph</name>
        <name evidence="1" type="ordered locus">UU115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU115"/>
    <dbReference type="EnsemblBacteria" id="AAF30521">
        <property type="protein sequence ID" value="AAF30521"/>
        <property type="gene ID" value="UU115"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU115"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_14"/>
    <dbReference type="OMA" id="TPHAKPH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="246" mass="28848" checksum="E37B3A2E7C22A3AE" modified="2000-10-01" version="1">MFMIILLLIIIQIRRKNKRFMTKKLIVFDFDGTIMHTHTTMSLSIIGVLEFYNHHIPSLKEMNDLLGNLSMVNIFKKYAKHDLLNIEIEMMISKYYEIYESSLFMIHSYFFDGILDLIKKLKSLNNNVKLAILSNKRSSLLATMVDYYNLRPYFDYIFGAEDVEQMKPDPSGLLKIMNNCNVDHKNTLLIGDSIADLKAAINANCHFILVNWEPQYQKHMETIINLKPLIVKTIDELETQINHFLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR33</accession>
    <name>Y111_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU111</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU111</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688801.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR33"/>
    <dbReference type="SMR" id="Q9PR33"/>
    <dbReference type="STRING" id="273119.UU111"/>
    <dbReference type="EnsemblBacteria" id="AAF30517">
        <property type="protein sequence ID" value="AAF30517"/>
        <property type="gene ID" value="UU111"/>
    </dbReference>
    <dbReference type="GeneID" id="29672739"/>
    <dbReference type="KEGG" id="uur:UU111"/>
    <dbReference type="eggNOG" id="COG4859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1365738_0_0_14"/>
    <dbReference type="OMA" id="WYSENSL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220799" description="Uncharacterized protein UU111">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <sequence length="200" mass="23944" checksum="34579DAE0573F115" modified="2000-10-01" version="1">MNYKYSAEEKQIIYNYILREYGQVDHIIFLSNEHIRVPIEYDILVIKKQNLQILMTFGLGAFKSHNHEENTQERAEIFLELPVDWDFNKHENMWPVHFLINIVKYSYSNHLTLKWLQTFINPSYFNKSNKIAGFLDLSWYGENSLECKINNDFFVSFYQILIIDDEELFYAKTNGIRALSKFFDDGKSRIVDLNRKSFVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR37</accession>
    <name>POTA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="1">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">potA</name>
        <name type="ordered locus">UU107</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + polyamine-[polyamine-binding protein]Side 1 = ADP + phosphate + polyamineSide 2 + [polyamine-binding protein]Side 1.</text>
            <dbReference type="EC" id="7.6.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688552.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR37"/>
    <dbReference type="SMR" id="Q9PR37"/>
    <dbReference type="STRING" id="273119.UU107"/>
    <dbReference type="EnsemblBacteria" id="AAF30513">
        <property type="protein sequence ID" value="AAF30513"/>
        <property type="gene ID" value="UU107"/>
    </dbReference>
    <dbReference type="GeneID" id="29672145"/>
    <dbReference type="KEGG" id="uur:UU107"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_14"/>
    <dbReference type="OMA" id="IRQKMQV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51305">
        <property type="entry name" value="POTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000286322" description="Spermidine/putrescine import ATP-binding protein PotA">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Insert">
        <location>
            <begin position="107"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01726"/>
        </source>
    </evidence>
    <sequence length="519" mass="59832" checksum="6912882189F75DD6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-04-23" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR38</accession>
    <name>SYS_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
            <shortName evidence="1">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS</name>
        <name type="ordered locus">UU106</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688660.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR38"/>
    <dbReference type="SMR" id="Q9PR38"/>
    <dbReference type="STRING" id="273119.UU106"/>
    <dbReference type="EnsemblBacteria" id="AAF30512">
        <property type="protein sequence ID" value="AAF30512"/>
        <property type="gene ID" value="UU106"/>
    </dbReference>
    <dbReference type="GeneID" id="29672764"/>
    <dbReference type="KEGG" id="uur:UU106"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_14"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000122152" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="418" mass="47814" checksum="88ECE732323D22B8" modified="2000-10-01" version="1">MFDINLIRKDIATTKEKMLNKKVPSNLFDQIFDLDVLVRSLMQQEQNLNAKKNQLSKEIGILAKNKDPKLQQTLDLVNNIKNELQDISLTLSNKQDELNKLLLVIPNMPDDSVPIGNDENDNVEIKKVFKPKKFDFLPLAHWDLAVKNKLIDFDKSTKITGSRFIIYTNFGARLYRALQQFCLDMNVKAGFSEIWAPVIVNQESLIGSGNLPKFADDLFKLENSNYYLSPTAEVQLTNLHRNEILKASDLPLYYTALTPCFRSEAGSAGRDVRGVIRQHQFHKVELVKLCKPEDSFKELESMTRQAESILEALELPYRRIVLCTGDLGFSSAKTYDLEVWLPSYNAYKEISSCSNCTNFQARRAKIRYKETIDATTELVHTLNGSSLAIDRLWAAIVENYQQEDGSINIPKVLKKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR40</accession>
    <name>Q9PR40_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ordered locus">UU104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU104"/>
    <dbReference type="EnsemblBacteria" id="AAF30510">
        <property type="protein sequence ID" value="AAF30510"/>
        <property type="gene ID" value="UU104"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU104"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_1_14"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="206" mass="23456" checksum="7141423C5EF5801A" modified="2000-10-01" version="1">MIKNQKTRNDGIKMKDIDPRIKEVLITEEQIDQKITEAANWINKEYEGKEPIIIGILKGCIPFIGKLLPKIKIDMKLDFLAISSFKGATSAQTEPEIITDLKFEVKDRDLILVEDIVDTGRTIKKVYDLLKIRGARSIKLVTLVDKKDGRLVDLQADFVCCDIPLVFIVGFGLDYKEIMRNLPYIGVLKEEVYQNDLNNKNEGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR41</accession>
    <name>Q9PR41_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688595.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU103"/>
    <dbReference type="EnsemblBacteria" id="AAF30509">
        <property type="protein sequence ID" value="AAF30509"/>
        <property type="gene ID" value="UU103"/>
    </dbReference>
    <dbReference type="GeneID" id="29672140"/>
    <dbReference type="KEGG" id="uur:UU103"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.109"/>
    <dbReference type="HOGENOM" id="CLU_491696_0_0_14"/>
    <dbReference type="OMA" id="NIARIFK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004335879" evidence="1">
        <location>
            <begin position="29"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="554" mass="65520" checksum="527828EA72C4A5C6" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR62</accession>
    <name>Q9PR62_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688479.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU083"/>
    <dbReference type="EnsemblBacteria" id="AAF30488">
        <property type="protein sequence ID" value="AAF30488"/>
        <property type="gene ID" value="UU083"/>
    </dbReference>
    <dbReference type="GeneID" id="29672282"/>
    <dbReference type="KEGG" id="uur:UU083"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.85"/>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_1_2_14"/>
    <dbReference type="OMA" id="VEHALNM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="156" mass="16953" checksum="B803F8AAA4A2EA94" modified="2000-10-01" version="1">MNVALELINLLKERRLRLSVCESASCGALSSSIGEVAGASSVFAGGFISYSNEVKIKLVGVSEKTIFKYGAVSEQTAKEMCLQTNQKFNTDIAISITGNAGPQGSENKEVGLFYIGIAIKDFAIVKKVTLNSNERTFNRFSIAWEAISYLIELIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR63</accession>
    <name>GYRA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase subunit A</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gyrA</name>
        <name type="ordered locus">UU082</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688806.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR63"/>
    <dbReference type="SMR" id="Q9PR63"/>
    <dbReference type="STRING" id="273119.UU082"/>
    <dbReference type="PRIDE" id="Q9PR63"/>
    <dbReference type="EnsemblBacteria" id="AAF30487">
        <property type="protein sequence ID" value="AAF30487"/>
        <property type="gene ID" value="UU082"/>
    </dbReference>
    <dbReference type="GeneID" id="29672273"/>
    <dbReference type="KEGG" id="uur:UU082"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_14"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0799">Topoisomerase</keyword>
    <feature type="chain" id="PRO_0000145272" description="DNA gyrase subunit A">
        <location>
            <begin position="1"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="1">
        <location>
            <begin position="543"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <sequence length="840" mass="94252" checksum="8D3DC66EB4DC1CF3" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR66</accession>
    <name>Q9PR66_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA pol III beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaN</name>
        <name evidence="12" type="ordered locus">UU079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688589.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU079"/>
    <dbReference type="EnsemblBacteria" id="AAF30484">
        <property type="protein sequence ID" value="AAF30484"/>
        <property type="gene ID" value="UU079"/>
    </dbReference>
    <dbReference type="GeneID" id="29672314"/>
    <dbReference type="KEGG" id="uur:UU079"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.81"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_2_0_14"/>
    <dbReference type="OMA" id="QFILPIR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="9">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="10">
        <location>
            <begin position="161"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="11">
        <location>
            <begin position="261"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAF30484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="379" mass="43371" checksum="7507E73A76C45B52" modified="2000-10-01" version="1">MEVFISIKKLIEAIKFSTTIANTNNANALLLGVLIEVSQNKISFKTTNNQVSGYKEITEGFEYFNSGKVLVTAKIILGLISKLKDKSVLLKQIDTNILLIKTENFETQINTMNIEGFPNLNFSLEDYVKISLPHQIMQEINTKVLPNVLNSQGIEKIQPISGILIDTQTLENKLIAIGTDKIKASCLIREYMGEKFKFIVSYSTMKLIIEILKNVEYSNNQTVDFYVRSRSLIFKINDAILQTRMIDGVYPNIYSIFDETNEENTYVFDRRLLIEIIERGMNIVMQEQNPKISIRIDKNEAEISLTTFEIGNMKEKMSIVNLNNKSAEFILNPSLLAHVLKNFDNNDVTFKVKDEILRPIIFIDTKDVGFKQILSRIKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR67</accession>
    <name>PTH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">UU078</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688439.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR67"/>
    <dbReference type="SMR" id="Q9PR67"/>
    <dbReference type="STRING" id="273119.UU078"/>
    <dbReference type="EnsemblBacteria" id="AAF30483">
        <property type="protein sequence ID" value="AAF30483"/>
        <property type="gene ID" value="UU078"/>
    </dbReference>
    <dbReference type="GeneID" id="29672163"/>
    <dbReference type="KEGG" id="uur:UU078"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_14"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187849" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="186" mass="20940" checksum="F02B08795754F518" modified="2000-10-01" version="1">MEKYLIVGLGNPGSNYAKTRHNVGFMVINEICNKLNLSLDSSKFNGIFTKTIYNNSIVFFCQPTTYMNLSGEFVIKMLNFYNIPIKNLIVIYDDVDTKLGTIKLRKKGSSGGQNGIKNIINILKTDEIKRIRIGIDKDPHIKLDQYVLSNFKIDELVIIKPAIIKGALATLAAIGEDFDKVMNKFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR68</accession>
    <name>TILS_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tilS</name>
        <name type="ordered locus">UU077</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR68"/>
    <dbReference type="SMR" id="Q9PR68"/>
    <dbReference type="STRING" id="273119.UU077"/>
    <dbReference type="EnsemblBacteria" id="AAF30482">
        <property type="protein sequence ID" value="AAF30482"/>
        <property type="gene ID" value="UU077"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU077"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_2_14"/>
    <dbReference type="OMA" id="GPDSMYL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000181799" description="tRNA(Ile)-lysidine synthase">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <sequence length="333" mass="40137" checksum="39BD610454AD6985" modified="2000-10-01" version="1">MKILIKLWTNLINRISNKKYLAAVSGGPDSMAMLNMYKRNIRVVCHVNYHKRESSDRDQQIVVDFCRKNNLIIEILDVDEKVYERYGHIDNFQTKARLIRYDFFKEIGKKYNIENLYIAHNFDDFLETAYMQRARQSKALFYGIKESNVINGIIVKRPVLFVRKQTLQRYCDENKIKYGIDETNELDIYERNRVRKIISSWSLNEVYDFKKFVIKYNKEHSSFANFIDLSYIEFKKNKYKYDYFIRQDDMVQYYLIYYFLIDHKIINPSENKIISLIKFFGKQINKEKAYRVQENIYMHVNDDELISLISYNKSDNISNSNVDIIDDHNVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR78</accession>
    <name>Q9PR78_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688529.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU067"/>
    <dbReference type="EnsemblBacteria" id="AAF30472">
        <property type="protein sequence ID" value="AAF30472"/>
        <property type="gene ID" value="UU067"/>
    </dbReference>
    <dbReference type="GeneID" id="29672179"/>
    <dbReference type="KEGG" id="uur:UU067"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.69"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1354118_0_0_14"/>
    <dbReference type="OMA" id="TPNIMGL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="204" mass="23842" checksum="C2386E794D484A0D" modified="2000-10-01" version="1">MDQYKINELIPSEYKLASYFNCGRITIHNAYEVLKVLGIVTTIKGSGYYVYSSIDHFTNKAFANLYKTIDNIKYEQFLIDFEYHGNKFNSITKFSLIKNKKIIAVSYYITPNNMDLEQFDTNNINISKQLILSGFDDFFNVKTQINYENINLLKSILEDENIKFNTPIILNKLTSSSLKVELLILTHISKEYFDYEETNKLIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR80</accession>
    <name>Q9PR80_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligoendopeptidase F</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF-1</name>
        <name evidence="9" type="ordered locus">UU065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has oligopeptidase activity and degrades a variety of small bioactive peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688614.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU065"/>
    <dbReference type="EnsemblBacteria" id="AAF30470">
        <property type="protein sequence ID" value="AAF30470"/>
        <property type="gene ID" value="UU065"/>
    </dbReference>
    <dbReference type="GeneID" id="29672767"/>
    <dbReference type="KEGG" id="uur:UU065"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.67"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_2_0_14"/>
    <dbReference type="OMA" id="YQREVYR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="194"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="608" mass="70830" checksum="F0B32DD54D1D0F6D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR90</accession>
    <name>Q9PR90_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane nuclease A-hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mnuA-1</name>
        <name evidence="3" type="ordered locus">UU055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU055"/>
    <dbReference type="EnsemblBacteria" id="AAF30460">
        <property type="protein sequence ID" value="AAF30460"/>
        <property type="gene ID" value="UU055"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU055"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279254_0_0_14"/>
    <dbReference type="OMA" id="THAFEFK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5_nucleotid_C" evidence="2">
        <location>
            <begin position="530"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1138" mass="131153" checksum="ED5C486B7F97D3AB" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR98</accession>
    <name>Q9PR98_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688541.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU047"/>
    <dbReference type="EnsemblBacteria" id="AAF30452">
        <property type="protein sequence ID" value="AAF30452"/>
        <property type="gene ID" value="UU047"/>
    </dbReference>
    <dbReference type="GeneID" id="29672278"/>
    <dbReference type="KEGG" id="uur:UU047"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.49"/>
    <dbReference type="eggNOG" id="ENOG5033SXH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015669_0_0_14"/>
    <dbReference type="OMA" id="RGTMWIL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022382">
        <property type="entry name" value="Mycoplasma_peptidase_DUF31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022381">
        <property type="entry name" value="Uncharacterised_MG067"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01732">
        <property type="entry name" value="DUF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00840">
        <property type="entry name" value="Y06768FAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004330950" evidence="1">
        <location>
            <begin position="24"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="DUF31" evidence="2">
        <location>
            <begin position="413"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="867" mass="99296" checksum="90656F7CE776B979" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA0</accession>
    <name>MALP_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Membrane-associated lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU045</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2011" name="J. Struct. Funct. Genomics" volume="12" first="27" last="32">
            <title>Solution NMR and X-ray crystal structures of membrane-associated Lipoprotein-17 domain reveal a novel fold.</title>
            <authorList>
                <consortium name="Northeast structural genomics consortium (NESG)"/>
                <person name="Mani R."/>
                <person name="Vorobiev S."/>
                <person name="Swapna G.V."/>
                <person name="Neely H."/>
                <person name="Janjua H."/>
                <person name="Ciccosanti C."/>
                <person name="Xiao R."/>
                <person name="Acton T.B."/>
                <person name="Everett J.K."/>
                <person name="Hunt J."/>
                <person name="Montelione G.T."/>
            </authorList>
            <dbReference type="PubMed" id="21153711"/>
            <dbReference type="DOI" id="10.1007/s10969-010-9099-2"/>
        </citation>
        <scope>STRUCTURE BY NMR OF 128-239</scope>
        <scope>X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) OF 133-249</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688743.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="PDB" id="2KRT">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=128-239"/>
    </dbReference>
    <dbReference type="PDB" id="3JVC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.69 A"/>
        <property type="chains" value="A/B/C=133-249"/>
    </dbReference>
    <dbReference type="PDB" id="3K63">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.49 A"/>
        <property type="chains" value="A=133-249"/>
    </dbReference>
    <dbReference type="PDBsum" id="2KRT"/>
    <dbReference type="PDBsum" id="3JVC"/>
    <dbReference type="PDBsum" id="3K63"/>
    <dbReference type="AlphaFoldDB" id="Q9PRA0"/>
    <dbReference type="BMRB" id="Q9PRA0"/>
    <dbReference type="SMR" id="Q9PRA0"/>
    <dbReference type="STRING" id="273119.UU045"/>
    <dbReference type="EnsemblBacteria" id="AAF30450">
        <property type="protein sequence ID" value="AAF30450"/>
        <property type="gene ID" value="UU045"/>
    </dbReference>
    <dbReference type="GeneID" id="29672285"/>
    <dbReference type="KEGG" id="uur:UU045"/>
    <dbReference type="eggNOG" id="ENOG5033SXH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015669_0_0_14"/>
    <dbReference type="OMA" id="SMWINAD"/>
    <dbReference type="EvolutionaryTrace" id="Q9PRA0"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007326">
        <property type="entry name" value="Lipoprotein-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022382">
        <property type="entry name" value="Mycoplasma_peptidase_DUF31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022381">
        <property type="entry name" value="Uncharacterised_MG067"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01732">
        <property type="entry name" value="DUF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04200">
        <property type="entry name" value="Lipoprotein_17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00840">
        <property type="entry name" value="Y06768FAMILY"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000413662" description="Membrane-associated lipoprotein">
        <location>
            <begin position="26"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoprotein-associated type-17">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="147"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="165"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="176"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="187"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="201"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="210"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="224"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="2KRT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3K63"/>
        </source>
    </evidence>
    <sequence length="834" mass="95985" checksum="01B5A9B2AC6BFDCA" modified="2000-10-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA4</accession>
    <name>Y041_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU041</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU041</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">To U.parvum UU007, UU008 and UU042.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025823.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRA4"/>
    <dbReference type="SMR" id="Q9PRA4"/>
    <dbReference type="STRING" id="273119.UU041"/>
    <dbReference type="EnsemblBacteria" id="AAF30446">
        <property type="protein sequence ID" value="AAF30446"/>
        <property type="gene ID" value="UU041"/>
    </dbReference>
    <dbReference type="GeneID" id="45015600"/>
    <dbReference type="KEGG" id="uur:UU041"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2048709_0_0_14"/>
    <dbReference type="OMA" id="IIAGMFQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220786" description="Uncharacterized protein UU041">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="120" mass="13467" checksum="C0B7C78C3D6C9B5F" modified="2000-10-01" version="1">MSSLPVIILVIGIFGSIFLVIGYIPQVIKVIKTKRTDGISLTFLISLNIACFLFVIYSILVMIFNKHNGIPTALPLCLANTIVGILGLVILIYKVKNIKKAKLYLMDEKTYYEKYVLNNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA5</accession>
    <name>RSMG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="1">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmG</name>
        <name type="ordered locus">UU040</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRA5"/>
    <dbReference type="SMR" id="Q9PRA5"/>
    <dbReference type="STRING" id="273119.UU040"/>
    <dbReference type="EnsemblBacteria" id="AAF30445">
        <property type="protein sequence ID" value="AAF30445"/>
        <property type="gene ID" value="UU040"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU040"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_0_1_14"/>
    <dbReference type="OMA" id="ICFPHLH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000184361" description="Ribosomal RNA small subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <sequence length="214" mass="25017" checksum="CD63701E100B2FA7" modified="2000-10-01" version="1">MSFEKYKTIIQKYNQIFNLTRLDSDDKIYQNFFLDSLAPYKELDFFTQNTNLKLIDIGSGSGIPGVVLKIIFKNLNLTLLEANQKRCEFLKILTQELGLNDVLIWNMRAEDLTQSMRESFDIATSRAVASLDKILEISAAFVKVNGYLIQPKSIKFYEEELKAKNIIKTLYLERIALKDFWENDYHHLVGVYLKKQITPLQFPRPWNLILKKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA7</accession>
    <name>Q9PRA7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">UU038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU038"/>
    <dbReference type="EnsemblBacteria" id="AAF30443">
        <property type="protein sequence ID" value="AAF30443"/>
        <property type="gene ID" value="UU038"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU038"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024970_3_0_14"/>
    <dbReference type="OMA" id="KENYRED"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AlbA_2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_4" evidence="5">
        <location>
            <begin position="288"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="463" mass="53861" checksum="FEEECFDD301260AF" modified="2000-10-01" version="1">MLNLKQYLGETNFYDKKEKLEKKKIKSWLKSVCTFANGQGGKLIFGVNENNNVLGLENYLNDSEFISETIKTKIDNIPEFDIEINEYENKIILILTIFPGRNPPYFLVDNGSKTPYKRVGNQSVIASINDLLNWCLRSQNRTYDSLVSNKLLKDVSFLMLKNEYQKHTENLWEDKFLKSFELIDNNNYLTNAGALFADGYQVYQSGVFCTRWNGKTKTNGLIEALDDAEFEGNLLFLLNSSINFIKRNSKNMWRKGVLYRIQYPEYPIKAVQEVIVNALIHRDYSIIGSEVHIDMYDDRLEVYSPGGMFDGNFVQNIDLYNVWSIRRNPILADLFARMNLMERRGSGLKNILEIYASKENYREDLKPEFRSTESAFFVVLKNLNYQEQNISKNENQKISPSQRRKKIIEFIGQNPKTTAYELTKIFFVSINTIERDLAKLVHDGYVEFVGSSKNGEWKIKTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA9</accession>
    <name>Q9PRA9_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891659.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU036"/>
    <dbReference type="REBASE" id="11419">
        <property type="entry name" value="M.UurORF36P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30441">
        <property type="protein sequence ID" value="AAF30441"/>
        <property type="gene ID" value="UU036"/>
    </dbReference>
    <dbReference type="GeneID" id="29672198"/>
    <dbReference type="KEGG" id="uur:UU036"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.39"/>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004516_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eco57I" evidence="3">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="277" mass="32808" checksum="7E2D339D07713E44" modified="2000-10-01" version="1">MKINIYDSKMDFVIGNPPYVRIHNLIKEPNLIKNYLFSNKGMTDLYIIFYEIGIKMLNKNGILCYITPSSFFTSLAGLNMRLFLSEYKLIESVCDLKHFQAFNATVYTTIICLNKSKKNECVEYYEFDEKKLKPCFIEKISHNDYFIKNNYYFGPKQKLIFLKKVLLSNKTTNILVKNGYATLSDKIFINDFDFESKFIIPVIKASKGELKKIFYPYDKENFLIDELVLKKDLKMYNYLKFNKNNLLKKIMILVQKIVDMHLVEVKELKILIRIKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC1</accession>
    <name>Q9PRC1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ABC substrate-binding protein-iron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ABCsbp-1</name>
        <name evidence="1" type="ordered locus">UU024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU024"/>
    <dbReference type="EnsemblBacteria" id="AAF30429">
        <property type="protein sequence ID" value="AAF30429"/>
        <property type="gene ID" value="UU024"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU024"/>
    <dbReference type="HOGENOM" id="CLU_586520_0_0_14"/>
    <dbReference type="OMA" id="WADSIDH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="470" mass="55272" checksum="69726082EBA3C20F" modified="2000-10-01" version="1">MVLIMKISFKFRLINVISMLGLSIIFTTLSSCKNLQQQKPYDTNWLFKNKNWRLNNFFRDPYKIHLEFARQLDNVLNFNELKKRLPKPMQNVHSFTEWSLKIARLLKNDINNVAMLDSIQKMRNHKATVLVIENRNELVNNKENYNKFSILTPSDFPLIYSNPYTEVPGLGLNFPKPINNDISDIIDRYQSIGYNALRTNPLESVLKQTSSFYKTADYVFYMYDSNLFTNNKYKTDGQKREDLFKEILSNKNFYAHKFLRNSRSKIIFIDRSLFWWGSFTMVGQSLIIKELLKIFTNKKTIKKQWSYLPFNKEELINLFDHKPTIKERNLIIKPHYINKNFKLTYGYKIVGTWADSIDHLISFGLKPDAIVDYESFNNINLKTQGVGNYLKELINYDKLEKINKAPNDSEKAEFVDKNFAIYMGPSHLLNSMNKLIMIKNTGSWIISSTQGINDPKTQFKTRINTAKSDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-07" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP5</accession>
    <name>KITH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidine kinase</fullName>
            <ecNumber evidence="1">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdk</name>
        <name type="ordered locus">UU594</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="17970" last="17975">
            <title>Structures of thymidine kinase 1 of human and mycoplasmic origin.</title>
            <authorList>
                <person name="Welin M."/>
                <person name="Kosinska U."/>
                <person name="Mikkelsen N.E."/>
                <person name="Carnrot C."/>
                <person name="Zhu C."/>
                <person name="Wang L."/>
                <person name="Eriksson S."/>
                <person name="Munch-Petersen B."/>
                <person name="Eklund H."/>
            </authorList>
            <dbReference type="PubMed" id="15611477"/>
            <dbReference type="DOI" id="10.1073/pnas.0406332102"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH ZINC IONS AND THYMIDINE</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="FEBS J." volume="272" first="6365" last="6372">
            <title>Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme.</title>
            <authorList>
                <person name="Kosinska U."/>
                <person name="Carnrot C."/>
                <person name="Eriksson S."/>
                <person name="Wang L."/>
                <person name="Eklund H."/>
            </authorList>
            <dbReference type="PubMed" id="16336273"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2005.05030.x"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC IONS AND THYMIDINE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 2 3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688765.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="PDB" id="2B8T">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B/C/D=1-223"/>
    </dbReference>
    <dbReference type="PDB" id="2UZ3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D=1-223"/>
    </dbReference>
    <dbReference type="PDBsum" id="2B8T"/>
    <dbReference type="PDBsum" id="2UZ3"/>
    <dbReference type="AlphaFoldDB" id="Q9PPP5"/>
    <dbReference type="SMR" id="Q9PPP5"/>
    <dbReference type="STRING" id="273119.UU594"/>
    <dbReference type="BindingDB" id="Q9PPP5"/>
    <dbReference type="ChEMBL" id="CHEMBL1075130"/>
    <dbReference type="DrugBank" id="DB02452">
        <property type="generic name" value="Thymidine 5'-triphosphate"/>
    </dbReference>
    <dbReference type="DrugCentral" id="Q9PPP5"/>
    <dbReference type="EnsemblBacteria" id="AAF31008">
        <property type="protein sequence ID" value="AAF31008"/>
        <property type="gene ID" value="UU594"/>
    </dbReference>
    <dbReference type="GeneID" id="29672699"/>
    <dbReference type="KEGG" id="uur:UU594"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_14"/>
    <dbReference type="OMA" id="ENTVNHK"/>
    <dbReference type="BRENDA" id="2.7.1.21">
        <property type="organism ID" value="9209"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q9PPP5"/>
    <dbReference type="PRO" id="PR:Q9PPP5"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0237">DNA synthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000175042" description="Thymidine kinase">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="178"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="136"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="144"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="187"/>
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        </location>
    </feature>
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        <location>
            <begin position="192"/>
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        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="207"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15611477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16336273"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2B8T"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2UZ3"/>
        </source>
    </evidence>
    <sequence length="223" mass="25367" checksum="27F3061B26979A0B" modified="2000-10-01" version="1">MAKVNAFSKKIGWIELITGPMFAGKTAELIRRLHRLEYADVKYLVFKPKIDTRSIRNIQSRTGTSLPSVEVESAPEILNYIMSNSFNDETKVIGIDEVQFFDDRICEVANILAENGFVVIISGLDKNFKGEPFGPIAKLFTYADKITKLTAICNECGAEATHSLRKIDGKHADYNDDIVKIGCQEFYSAVCRHHHKVPNRPYLNSNSEEFIKFFKNKKRNKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP6</accession>
    <name>Q9PPP6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688427.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU593"/>
    <dbReference type="EnsemblBacteria" id="AAF31007">
        <property type="protein sequence ID" value="AAF31007"/>
        <property type="gene ID" value="UU593"/>
    </dbReference>
    <dbReference type="GeneID" id="29672769"/>
    <dbReference type="KEGG" id="uur:UU593"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.616"/>
    <dbReference type="HOGENOM" id="CLU_1776667_0_0_14"/>
    <dbReference type="OMA" id="WIIFHNS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF31007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="146" mass="17787" checksum="51C9EA6AF81223C9" modified="2000-10-01" version="1">MKIVLEELKDYLIGKLYFKYKFIGVFISIFLAGWLISFITNLILALNYGYNEKLLNYKKYLDFTILTCISFLMLFITIIYLLWINCHNSTARYLILKINKYPPKKPIKNLPFIFFRLAYYTFNIRQKIQYQQKQIYKYLISFNEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP9</accession>
    <name>Q9PPP9_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">topA</name>
        <name evidence="12" type="ordered locus">UU590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689031.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU590"/>
    <dbReference type="EnsemblBacteria" id="AAF31004">
        <property type="protein sequence ID" value="AAF31004"/>
        <property type="gene ID" value="UU590"/>
    </dbReference>
    <dbReference type="GeneID" id="29672262"/>
    <dbReference type="KEGG" id="uur:UU590"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.613"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_14"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="167"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAF31004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="677" mass="78759" checksum="ECE94EBBF4514D46" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ1</accession>
    <name>Q9PPQ1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cls</name>
        <name evidence="3" type="ordered locus">UU588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688738.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU588"/>
    <dbReference type="EnsemblBacteria" id="AAF31002">
        <property type="protein sequence ID" value="AAF31002"/>
        <property type="gene ID" value="UU588"/>
    </dbReference>
    <dbReference type="GeneID" id="29672563"/>
    <dbReference type="KEGG" id="uur:UU588"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.611"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038053_1_2_14"/>
    <dbReference type="OMA" id="TRFILDW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF31002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="532" mass="62077" checksum="B1DBA4EA0F3B2185" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR1</accession>
    <name>Q9PPR1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689042.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30992">
        <property type="protein sequence ID" value="AAF30992"/>
        <property type="gene ID" value="UU578"/>
    </dbReference>
    <dbReference type="GeneID" id="29672177"/>
    <dbReference type="KEGG" id="uur:UU578"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.601"/>
    <dbReference type="HOGENOM" id="CLU_517716_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331058" evidence="1">
        <location>
            <begin position="27"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="526" mass="60712" checksum="C158E0E950021B51" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR3</accession>
    <name>RS9_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsI</name>
        <name evidence="1" type="synonym">rps9</name>
        <name type="ordered locus">UU576</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688496.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPR3"/>
    <dbReference type="SMR" id="Q9PPR3"/>
    <dbReference type="STRING" id="273119.UU576"/>
    <dbReference type="EnsemblBacteria" id="AAF30990">
        <property type="protein sequence ID" value="AAF30990"/>
        <property type="gene ID" value="UU576"/>
    </dbReference>
    <dbReference type="GeneID" id="29672154"/>
    <dbReference type="KEGG" id="uur:UU576"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_14"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000111436" description="30S ribosomal protein S9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <sequence length="133" mass="14981" checksum="684465624A7D34C8" modified="2000-10-01" version="1">MQKSNIVEYKGLGRRKSSIARVKLVPGSGKVLVNDRQPENYFPNKLVIQDMMQPLVLTKTAETYDVYVKVIGGGFNGQAGAIRLGITRALIQTREDLKTDLRKAGLVTRDSRVKERKKFGLYGARRAPQFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR6</accession>
    <name>Q9PPR6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kch</name>
        <name evidence="9" type="ordered locus">UU573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688606.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU573"/>
    <dbReference type="EnsemblBacteria" id="AAF30987">
        <property type="protein sequence ID" value="AAF30987"/>
        <property type="gene ID" value="UU573"/>
    </dbReference>
    <dbReference type="GeneID" id="29672771"/>
    <dbReference type="KEGG" id="uur:UU573"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.596"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640831_0_0_14"/>
    <dbReference type="OMA" id="NAYMNIV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="8">
        <location>
            <begin position="225"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="428" mass="50799" checksum="D74E17E0A32A98A3" modified="2000-10-01" version="1">MTNDERKEFIRKNKIIYFNRIRYFFYEWTDMKAYQRMLVPETFFSFFYQLFVLMIAFCSVTIIIYNQIELKQANEEHIDFIAKYFEVYYAFNIFFIIDYLIRISYADYTYNSISRLKAFLIAPFRFVNLLDLVSFVAIVIIYNTGLLDFVAKMNETTSYSQKFDYYYQIINNNAYMNVVPCMFLIKILGAHSKIIKNVILSSEVNFFWQIFKRRWRVLLSSFLILVLFTFLLSFIIYRIEQNYYEIKHILPGNPLYKLKNFGETLWFSMGTITTIAYGDVTPVSPAGKVFAVILGVIGVTYYGFLTSLFASALISVINEFGKRRDSRRLLEFQNENERLLHEFSEQIKVDIVQELIKNNVIQDPEEIKRIEDLQNQEREALKMKAKRRKKIYFSDDLFDDTKRISVSNVKVRSASNVTKVLGRSSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR8</accession>
    <name>Q9PPR8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891818.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU571"/>
    <dbReference type="EnsemblBacteria" id="AAF30985">
        <property type="protein sequence ID" value="AAF30985"/>
        <property type="gene ID" value="UU571"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU571"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.594"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000788_4_0_14"/>
    <dbReference type="OMA" id="NTIIWGP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025103">
        <property type="entry name" value="DUF4011"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13195">
        <property type="entry name" value="DUF4011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1367" mass="160323" checksum="DB073CF7289B0F12" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS6</accession>
    <name>Q9PPS6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688586.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU564"/>
    <dbReference type="EnsemblBacteria" id="AAF30977">
        <property type="protein sequence ID" value="AAF30977"/>
        <property type="gene ID" value="UU564"/>
    </dbReference>
    <dbReference type="GeneID" id="29672646"/>
    <dbReference type="KEGG" id="uur:UU564"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.586"/>
    <dbReference type="HOGENOM" id="CLU_692511_0_0_14"/>
    <dbReference type="OMA" id="RYMINEI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="397" mass="46557" checksum="7935DCA701D14455" modified="2000-10-01" version="1">MKTKSNLKARLIIFISILLTTIISLVLLTSCSTKKSKKVTINQDTQIKFQSITNNNINLANEKQILNQSQNKETKIFLNLYESLKDYFDQTIKRSLYLYYSYNFALLNLYNAKYHVKLNDFSLIYNTDKNSNNGTFDINYKLGLVIDDIGDINIQTKPQFYEPIPPDKKVRNDDYHFTKKIKRFWFGSKKAIIDYFNEAISMQINYSNVKIYHSIIKYPDSKEHYEGYTITGGSLYRWVKQAIPTDDNQNKVRYMISKINDLNIDNDVKLFNLNDLVLKQIFIVDRPAQTSIKPERDLVYTNIWNNKLDDFYFSPIAFLAPTFIKKNGKKITPFNLKTNKEYLDNLYENLLIQGQKNNNALIKGMYVIYSMYSYFDLTLEPKKPGSIHHCHADGFCH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT6</accession>
    <name>RS6_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpsF</name>
        <name type="synonym">rps6</name>
        <name type="ordered locus">UU554</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688782.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPT6"/>
    <dbReference type="SMR" id="Q9PPT6"/>
    <dbReference type="STRING" id="273119.UU554"/>
    <dbReference type="EnsemblBacteria" id="AAF30967">
        <property type="protein sequence ID" value="AAF30967"/>
        <property type="gene ID" value="UU554"/>
    </dbReference>
    <dbReference type="GeneID" id="29672549"/>
    <dbReference type="KEGG" id="uur:UU554"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139827_0_0_14"/>
    <dbReference type="OMA" id="WSDKLAY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000176870" description="30S ribosomal protein S6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="160" mass="18722" checksum="207B409D6B78BDC1" modified="2000-10-01" version="1">MAKYEIMLVVRGDLDQEQANKVANELKATLKNTEVKENNYDGVQQLAYEINKLKTAYRYVYNFETTDVSLINEFRRLAIINKNVLRHIIINLEKDYGYKATVNTKKVQRNEKRAEVYARQKEEAERRAVERQAAYEAMKAEREAAGLPVKEFVKNTNSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPU3</accession>
    <name>Q9PPU3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU547"/>
    <dbReference type="EnsemblBacteria" id="AAF30960">
        <property type="protein sequence ID" value="AAF30960"/>
        <property type="gene ID" value="UU547"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU547"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_798518_0_0_14"/>
    <dbReference type="OMA" id="MTAGVFH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="338" mass="37750" checksum="1EE4404007D96305" modified="2000-10-01" version="1">MSVLHTTNTSQGNGINSWQSILIFLAFLIVFIIFTVIKKIYYSIRFQKRFYIIPKTSVKGISNIAMVISISVAVIILLTVLSANTASVIFRAWPGTRVTLEGILIKIGGLLFGPILGIFIGAMTDLLSVAMTAGVFHYGYLIAAMAYGLIGGLIRIILTTSKKKDLPFAIYSSMATILIGVGIALFLYFAPGIGDKGFNIQLFGFDIKIARTLMIGIILGFFLLSIIVVWFSLLIKYWFNKKNKAKTKTNWFIIFAPVLVTILLTEAVVNVLMMPSFDAELSSLKYTQWLSIRAVLFIPMVVLNLLIIYPIFKIVVPLIRYDYEDDIVEDKHIPIHVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV2</accession>
    <name>ECFA2_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
            <shortName evidence="1">ECF transporter A component EcfA2</shortName>
            <ecNumber evidence="1">3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ecfA2</name>
        <name type="synonym">cbiO2</name>
        <name type="ordered locus">UU538</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688554.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPV2"/>
    <dbReference type="SMR" id="Q9PPV2"/>
    <dbReference type="STRING" id="273119.UU538"/>
    <dbReference type="EnsemblBacteria" id="AAF30951">
        <property type="protein sequence ID" value="AAF30951"/>
        <property type="gene ID" value="UU538"/>
    </dbReference>
    <dbReference type="GeneID" id="29672424"/>
    <dbReference type="KEGG" id="uur:UU538"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_14"/>
    <dbReference type="OMA" id="QVHKYYG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51246">
        <property type="entry name" value="CBIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092124" description="Energy-coupling factor transporter ATP-binding protein EcfA2">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01710"/>
        </source>
    </evidence>
    <sequence length="433" mass="50401" checksum="465504D95A9B61D4" modified="2000-10-01" version="1">MQKLMDYFFKRKLKVPRPISNDISVRVKNLYAVYDEKQENQLVALNNISYDFKKNKIYFIIGNSGSGKSTLVTHFNGLMISRYGFVQVGDIVSGDHFDFERQLLGVIDSYDKKIINLLWRNQLDQWTFLVLFSNEVNIQQARILFEANFKQKPISLKFIKTKNNHELITNPYVRENTKIAVVRVDKNVILEINDKMNYEELQRFEFIKKEIKTNYHLSKKIKRFKELRRRVGFVFQFPEYQLFKDTIEKDIMFGPVNLGVKKSEAKKRAKFYLNKLGLGDDYLERSPFGLSGGQKRRVAIAGILAIQNDILVFDEPTAGLDPAGEHEMMQIILDAKANNKTVFVITHTMEHVLEVADEVIVMDEGEIIKTGTPYEIFFDQHIINSTSIQVPRVIAVINELIKKDLKYEILKQKQPRTIEELADAIIEFKKGEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-02-28" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV5</accession>
    <name>Y535_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>DegV domain-containing protein UU535</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU535</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688585.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPV5"/>
    <dbReference type="SMR" id="Q9PPV5"/>
    <dbReference type="STRING" id="273119.UU535"/>
    <dbReference type="EnsemblBacteria" id="AAF30948">
        <property type="protein sequence ID" value="AAF30948"/>
        <property type="gene ID" value="UU535"/>
    </dbReference>
    <dbReference type="GeneID" id="29672410"/>
    <dbReference type="KEGG" id="uur:UU535"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949782_0_0_14"/>
    <dbReference type="OMA" id="LETIGAC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000209820" description="DegV domain-containing protein UU535">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DegV" evidence="3">
        <location>
            <begin position="5"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>hexadecanoate</name>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>hexadecanoate</name>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9X1H9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00815"/>
        </source>
    </evidence>
    <sequence length="298" mass="34039" checksum="227F6D24FB0DB612" modified="2000-10-01" version="1">MKKSFLIMTDSSTTLDREWAKNNDVMILPLSILRSDHTLIVDDGIESKPERIYEDIDNGYTFQTSCTPYGVLIEAIEQKLQEYEKIIFIGISSGFSSQFNNAKNLEKEYQDKLFVVDTEDFGYSLEHLVYKIKAMLSNNISFGDILKMINKHHDYTSSFLACENITGLVRSGRIPKIIGTMLKLSKVTPIIKAEWKNHRAGMALNIRSAPHKILENINHVFDNQLNNHTIEKVCILQAGLSSERIDELKNDVINHFHVDKEKIVIRSGPPIFLVYVWKGALGIQVIANIPKKHVEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW4</accession>
    <name>Q9PPW4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBA N-terminal paralog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688770.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU526"/>
    <dbReference type="EnsemblBacteria" id="AAF30939">
        <property type="protein sequence ID" value="AAF30939"/>
        <property type="gene ID" value="UU526"/>
    </dbReference>
    <dbReference type="GeneID" id="29672364"/>
    <dbReference type="KEGG" id="uur:UU526"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.546"/>
    <dbReference type="eggNOG" id="COG2503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041914_0_0_14"/>
    <dbReference type="OMA" id="NQRWLSN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006423">
        <property type="entry name" value="Lipo_e_P4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01125">
        <property type="entry name" value="C1.1:_Acid_Phosphatase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004332329" evidence="2">
        <location>
            <begin position="26"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="503" mass="56826" checksum="7FE1BA9A3F04E6B6" modified="2000-10-01" version="1">MKLLKNKKFWAISLGSIIVSTSIIATATACTNSNIESTVSSSFVRTQNGVYAIYEITNWTKLDDNQKKSLQNLNFKTSVIDKDNNAEFTSSTGILRDGRVYVKLAREPKKDDRVIIKPDDANLKKGAVYVTTLNISNIELNDGPKVQISHSNEKNEIKSYNSAESIIYNQRWLANIWNTLSAEKDGMLLTEYNSAKHQFDAMIKQSDFDTSKVKVEKDSNGNITKVTVSNPESNKAIPVVFMDIDETILNNYANQNYQLLNNKAYNPKDWDAFVNDKVSKRLAGAFEFIKYVWEHGGVVMFNSNREQENQVDPTIENLVSEGLERSLLPKWIFWMQGVDFSSDKPWANIKKDAQGKRVKSTKEDRMNAMNKRTQGYDLSEFGSGNAVVLKTVMRIGDNFDDFNDNASKGKLNSERVALLKEYGKLFGNFDINNKGVKYEKNQNGQMVKSDETWSESYVLIGGNSSYGGFEAGIAKGYYGLGKEGQAKALKDYIKQLYWEPKSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-11-16" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW6</accession>
    <name>RS7_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name evidence="1" type="synonym">rps7</name>
        <name type="ordered locus">UU524</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026103.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPW6"/>
    <dbReference type="SMR" id="Q9PPW6"/>
    <dbReference type="STRING" id="273119.UU524"/>
    <dbReference type="EnsemblBacteria" id="AAF30937">
        <property type="protein sequence ID" value="AAF30937"/>
        <property type="gene ID" value="UU524"/>
    </dbReference>
    <dbReference type="GeneID" id="45016146"/>
    <dbReference type="KEGG" id="uur:UU524"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_14"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000124376" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="155" mass="17745" checksum="BA7E5FAF67C51765" modified="2000-10-01" version="1">MRKLKPQKRQVLADPVYNSRLVTKLINAIMYDGKKGLAQSIIYSAFEIVEQKTGKPALEVFNKAIDNVMPIIELKVRRVGGSNFQVPTEVTPERRQTLGLRWITLYARLRHEHTMIEKLAHEIIDASNNVGAAIKKKEDTHKMAEANKAFAHLRW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-10" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX5</accession>
    <name>EFTS_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsf</name>
        <name type="ordered locus">UU514</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688642.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPX5"/>
    <dbReference type="SMR" id="Q9PPX5"/>
    <dbReference type="STRING" id="273119.UU514"/>
    <dbReference type="PRIDE" id="Q9PPX5"/>
    <dbReference type="EnsemblBacteria" id="AAF30927">
        <property type="protein sequence ID" value="AAF30927"/>
        <property type="gene ID" value="UU514"/>
    </dbReference>
    <dbReference type="GeneID" id="29672215"/>
    <dbReference type="KEGG" id="uur:UU514"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_0_2_14"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000161228" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="78"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <sequence length="291" mass="32535" checksum="D3F0949D94DC04F9" modified="2000-10-01" version="1">MTKAELVKELRIRTQASMSECIKALDASENDIEKAIVWLRENGAIKAANKLKNAATDGVVLAKKINNKAILIEVNCQTDFVAKNENFLAYANQILEEALAKVENKEDFDKLIINGKPIAESGLDLTAYIGEKIVFRRGEILKANDDQTLGVYTHNNNRVAAIILVDGKVEDEVVRNVAMHAAAMRPRYLNEKVVDKLWLAKEREIIVNQLEHEGKPAAFAAKIIDGRLNKILKENCLVDQSYFKQPELTIEKYLKNNNAVAVGYFSYEVGEGIEKAPQMSFADEVAAQMKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-08-30" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX6</accession>
    <name>PYRH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uridylate kinase</fullName>
            <shortName>UK</shortName>
            <ecNumber>2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Uridine monophosphate kinase</fullName>
            <shortName>UMP kinase</shortName>
            <shortName>UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pyrH</name>
        <name type="ordered locus">UU513</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="FEBS J." volume="274" first="1983" last="1990">
            <title>The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates.</title>
            <authorList>
                <person name="Wang L."/>
            </authorList>
            <dbReference type="PubMed" id="17355283"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2007.05742.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="FEBS J." volume="274" first="6403" last="6414">
            <title>Structural and functional investigations of Ureaplasma parvum UMP kinase - a potential antibacterial drug target.</title>
            <authorList>
                <person name="Egeblad-Welin L."/>
                <person name="Welin M."/>
                <person name="Wang L."/>
                <person name="Eriksson S."/>
            </authorList>
            <dbReference type="PubMed" id="18021254"/>
            <dbReference type="DOI" id="10.1111/j.1742-4658.2007.06157.x"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)</scope>
        <scope>FUNCTION</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <scope>MUTAGENESIS OF PHE-133</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. Is also able to phosphorylate dUMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">Unlike other bacteria, is not activated by GTP. UTP is a competitive inhibitor against UMP and a non-competitive inhibitor toward ATP.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="3">214 uM for UMP</KM>
            <Vmax evidence="3">262.0 umol/min/mg enzyme</Vmax>
            <text>Positive cooperativity is observed with ATP as variable substrate, but it is abolished in the presence of UTP.</text>
        </kinetics>
        <phDependence>
            <text evidence="3">Optimum pH is 6.8.</text>
        </phDependence>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688575.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="PDB" id="2VA1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-235"/>
    </dbReference>
    <dbReference type="PDBsum" id="2VA1"/>
    <dbReference type="AlphaFoldDB" id="Q9PPX6"/>
    <dbReference type="SMR" id="Q9PPX6"/>
    <dbReference type="STRING" id="273119.UU513"/>
    <dbReference type="EnsemblBacteria" id="AAF30926">
        <property type="protein sequence ID" value="AAF30926"/>
        <property type="gene ID" value="UU513"/>
    </dbReference>
    <dbReference type="GeneID" id="29672214"/>
    <dbReference type="KEGG" id="uur:UU513"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_1_14"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="BRENDA" id="2.7.4.22">
        <property type="organism ID" value="9209"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q9PPX6"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000143902" description="Uridylate kinase">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Still no activation by GTP. Exhibits negative cooperativity with UMP. Marked decrease in activity." evidence="3">
        <original>F</original>
        <variation>N</variation>
        <variation>A</variation>
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="4"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="42"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="56"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="95"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="112"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="124"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="152"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="178"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="183"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="196"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="208"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="219"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="231"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="17355283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="18021254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2VA1"/>
        </source>
    </evidence>
    <sequence length="235" mass="25924" checksum="CAF39D32C3DFCE2D" modified="2000-10-01" version="1">MRKQRIVIKISGACLKQNDSSIIDFIKINDLAEQIEKISKKYIVSIVLGGGNIWRGSIAKELDMDRNLADNMGMMATIINGLALENALNHLNVNTIVLSAIKCDKLVHESSANNIKKAIEKEQVMIFVAGTGFPYFTTDSCAAIRAAETESSIILMGKNGVDGVYDSDPKINPNAQFYEHITFNMALTQNLKVMDATALALCQENNINLLVFNIDKPNAIVDVLEKKNKYTIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY7</accession>
    <name>Q9PPY7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">epsG</name>
        <name evidence="2" type="ordered locus">UU503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688448.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU503"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30915">
        <property type="protein sequence ID" value="AAF30915"/>
        <property type="gene ID" value="UU503"/>
    </dbReference>
    <dbReference type="GeneID" id="29672576"/>
    <dbReference type="KEGG" id="uur:UU503"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.520"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905965_0_0_14"/>
    <dbReference type="OMA" id="FLIDEPA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="312" mass="37009" checksum="61541598349D5CE1" modified="2000-10-01" version="1">MLLTIAFYLSKTTHYLKKNFNYFLDLLNQNQKNIELIIIDDASDYNLFKTLKPLIENTNAKIKYFYLNETQGNAYAYNLATKYAHGKYIWYLGGHVELNLDASSLLFSVLEKDYDVISFNLNDNVNQNPSLVFDSLNKEILVGLWESVSNKIIALDFIRKNKLAFYNDKWYPALFIYDLFTKFNSWRNVNINFISNNSGEVGYNVYDLLQQINELYIRFSNDDLLDLYKDELCYWITGICFHSFLKKIYELYTININSKKQIKERTMIISHALSNAKKYLEIYFANFENNLYVRKFKINILKYYLKSKQGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPZ0</accession>
    <name>Q9PPZ0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688486.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU500"/>
    <dbReference type="EnsemblBacteria" id="AAF30912">
        <property type="protein sequence ID" value="AAF30912"/>
        <property type="gene ID" value="UU500"/>
    </dbReference>
    <dbReference type="GeneID" id="29672344"/>
    <dbReference type="KEGG" id="uur:UU500"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.517"/>
    <dbReference type="eggNOG" id="COG1692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068238_0_0_14"/>
    <dbReference type="OMA" id="NHIWDKK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="263" mass="29793" checksum="C5FC9A5EB01CAD35" modified="2000-10-01" version="1">MKILAIGDIFSKQGRKAVANELPKLKQEYQIDFVIANAENTTHGRGLCWKHYEELLGYGIDCITMGNHTWDHPDIFEILTTKTNIIRPYNIINTHQYHLVGSGSRVFYCNKKMIRVTNLLGNSIDMKGLQTNPFESLDKIIAFNEAPIHIVDFHAETTSEKNALFLDFKSKLSLVYGTHTHIPTNDARIVDHTAFQTDLGMCGAANSVIGANPSSIIQRFRDPNKRFILEPSDEKYVFCASLVEIDDETNFPTNITPIVIYEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-12-06" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPZ2</accession>
    <name>RS4_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name evidence="1" type="synonym">rps4</name>
        <name type="ordered locus">UU498</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688490.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPZ2"/>
    <dbReference type="SMR" id="Q9PPZ2"/>
    <dbReference type="STRING" id="273119.UU498"/>
    <dbReference type="EnsemblBacteria" id="AAF30910">
        <property type="protein sequence ID" value="AAF30910"/>
        <property type="gene ID" value="UU498"/>
    </dbReference>
    <dbReference type="GeneID" id="29672308"/>
    <dbReference type="KEGG" id="uur:UU498"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_1_14"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132489" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="202" mass="23124" checksum="F929E0AF52848C2E" modified="2000-10-01" version="1">MSRYTGSIYKKSRRLGFSLLENNKEFNSGKKRTYGPGQHGNKKVKLSNYGQQLVEKQKLMFLYGLNDRQFRRLYRVALGRPGVLTLNLLQVLESRLDSLVYRAGFAPTRRAARQLVNHSHVLVNNKKVNIPSALVEVGSTIALKAKSLEIPLIKNTLNKPADFIELIDKEKKVAKLARLPERNELPADVNEAYVVEWYNRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPZ5</accession>
    <name>Q9PPZ5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU495"/>
    <dbReference type="EnsemblBacteria" id="AAF30907">
        <property type="protein sequence ID" value="AAF30907"/>
        <property type="gene ID" value="UU495"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU495"/>
    <dbReference type="HOGENOM" id="CLU_223517_0_0_14"/>
    <dbReference type="OMA" id="DNQIADK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="2844"/>
            <end position="2879"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="5005" mass="572700" checksum="DE00D84F1D409205" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ03</accession>
    <name>Q9PQ03_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBA N-terminal paralog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891797.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU487"/>
    <dbReference type="EnsemblBacteria" id="AAF30899">
        <property type="protein sequence ID" value="AAF30899"/>
        <property type="gene ID" value="UU487"/>
    </dbReference>
    <dbReference type="GeneID" id="29672452"/>
    <dbReference type="KEGG" id="uur:UU487"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.504"/>
    <dbReference type="HOGENOM" id="CLU_318545_0_0_14"/>
    <dbReference type="OMA" id="MIQISTP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="913" mass="106011" checksum="FE9AD007C44AE0E3" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ09</accession>
    <name>Q9PQ09_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30893">
        <property type="protein sequence ID" value="AAF30893"/>
        <property type="gene ID" value="UU481"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU481"/>
    <dbReference type="HOGENOM" id="CLU_324891_0_0_14"/>
    <dbReference type="OMA" id="KSSRYQF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="182"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="888" mass="102985" checksum="65D5273D5D1D07B8" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ17</accession>
    <name>Q9PQ17_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU473"/>
    <dbReference type="EnsemblBacteria" id="AAF30885">
        <property type="protein sequence ID" value="AAF30885"/>
        <property type="gene ID" value="UU473"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU473"/>
    <dbReference type="HOGENOM" id="CLU_360900_0_0_14"/>
    <dbReference type="OMA" id="DNTIFAP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="187"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="775" mass="89588" checksum="376C620B1EE9A78F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ19</accession>
    <name>Q9PQ19_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU471"/>
    <dbReference type="EnsemblBacteria" id="AAF30883">
        <property type="protein sequence ID" value="AAF30883"/>
        <property type="gene ID" value="UU471"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU471"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.487"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3031164_0_0_14"/>
    <dbReference type="OMA" id="VSEHIMH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="63" mass="7217" checksum="396BD8D1EF29C4A0" modified="2000-10-01" version="1">MELAAIAHVCTRMLTPLVSIKLVSDHITLPNSNQEQFNKNLSLIDKWFNEHLPSIIEAILEIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ29</accession>
    <name>OBG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Obg</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">obg</name>
        <name type="ordered locus">UU461</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688605.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ29"/>
    <dbReference type="SMR" id="Q9PQ29"/>
    <dbReference type="STRING" id="273119.UU461"/>
    <dbReference type="EnsemblBacteria" id="AAF30873">
        <property type="protein sequence ID" value="AAF30873"/>
        <property type="gene ID" value="UU461"/>
    </dbReference>
    <dbReference type="GeneID" id="29672770"/>
    <dbReference type="KEGG" id="uur:UU461"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_1_14"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
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        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
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        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
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        <property type="entry name" value="GTP1-OBG_CS"/>
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    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
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        <property type="entry name" value="OCT_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000386372" description="GTPase Obg">
        <location>
            <begin position="1"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="3">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="1">
        <location>
            <begin position="160"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="2">
        <location>
            <begin position="357"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01231"/>
        </source>
    </evidence>
    <sequence length="435" mass="48696" checksum="285F5B7CB47C41C7" modified="2000-10-01" version="1">MAFIDKCKIVLIAGNGGDGIVSWRRETHVPEGGPAGGNGGNGGSIWFVGNHNETSLEFLKYKKIIRAKHGEKGDIKNQHGANAEDVFINVPLGTVVYNPITNEILADINIDQQKYLVAQGGLGGHGNTHFKSPFNKAPNLYELGELGENVEVLLELKTIADIGIIGLPNAGKSTLISTFTNAKPKTANYMFTTLNPVLGTIYRDQNRIIFADIPGLIEGAHTGVGLGHDFLKHIERCFLLIHLISLDPNDNPDIINAYETIVNELKQYKQNLVNKPIVLVANKIDQIGALENLQILKEYLKNNQEIKIISALTNLHVDNMLDDVIKIYFAQKKIYEQRLKEQLPVDQILKWTSDIPKSKELDKTIEIIKVDDHIFEVFGEYLKYWAHRIPLKTQDNLIRFNQKLQSINFNQQLLQAGAVAGDSIKIYDITLEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ47</accession>
    <name>Q9PQ47_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Mollicutes</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
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                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
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            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004335867" evidence="2">
        <location>
            <begin position="24"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="628" mass="72753" checksum="669694C772F9A85C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ49</accession>
    <name>Q9PQ49_UREPA</name>
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        <submittedName>
            <fullName evidence="5">Unique hypothetical</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">UU441</name>
    </gene>
    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
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                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
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                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GeneID" id="29672478"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="450" mass="52948" checksum="8D0BAB5D1FBA6206" modified="2000-10-01" version="1">MIVKIEKVHLYSLDINAKDETSENSHIKIWKELDWLIQNDVKIINHSYGWSPNDFLNIGFYNFINGKEINDDKDFKRELKKYIDTLNKDDIVNNTINKYKFKNYIYDFISYYFDIINIFSAGNSYNDEIRYRNKNGHILEINWFDISKYSFMDRFNQNSIYVGSTNKNNEKVSNFSDRHHLNDVKNKYGDLLMPFLVAPGEGIYDTSIITKFIKNKGDKNINLGTSFSAPIVTGAISLLQSYYMVNNANKTIPLTHIRSILAASSIPLKNNENYDFYKNSFSHLYGAGHLDFKRAIEAYKNAKQTKILTKHKDKQLVKEMDISIDNDQTNFNFALSWLFKPTSNSFSKKHDYNSVYNEYKKLTYFKNDNYDIYLVKNEDLKNIDYQNFDNFGEILRTINIYRSESDSNVELIRAPNLNKGEYKILVYQKGEVRNEQTSFSYTFIKEKAIH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ68</accession>
    <name>HRCA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hrcA</name>
        <name type="ordered locus">UU421</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688647.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ68"/>
    <dbReference type="SMR" id="Q9PQ68"/>
    <dbReference type="STRING" id="273119.UU421"/>
    <dbReference type="EnsemblBacteria" id="AAF30832">
        <property type="protein sequence ID" value="AAF30832"/>
        <property type="gene ID" value="UU421"/>
    </dbReference>
    <dbReference type="GeneID" id="29672623"/>
    <dbReference type="KEGG" id="uur:UU421"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_1_0_14"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000182554" description="Heat-inducible transcription repressor HrcA">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <sequence length="357" mass="40792" checksum="2F1C3DD09028C63D" modified="2000-10-01" version="1">MKNTKTSQEQVIELKLSDRQKKVLKSIVDEYTISATPVSSKLLVQKEFKDQSSATIRNEMMFLEKNGLIEKQHISGGRVPSLKGYDFYNKNLINKNNNVSDNFKMRLHKILSKRYSNIDEILNAAVSIINETTQLPAVVTKTSSDELLKRIDLVKINDNSALVLIVTSSENILTHSIKLDKNTKFNDLQTCFSVLDERLVDTKLSLISSKLDLIVDIVRNKLEEVEYYFSKIVHRVFDFYAYKPNIDSKTYGVKYLTKHSEFEDQQKLNDLLNLLEDSTIWQQIALNKKTDGLAKIMLGNEIGHEHLAIATTQINLANTNHQITVVGPTRMDYAKIKALLDFLKIEIEKILGSTNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ72</accession>
    <name>Q9PQ72_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688714.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU417"/>
    <dbReference type="EnsemblBacteria" id="AAF30828">
        <property type="protein sequence ID" value="AAF30828"/>
        <property type="gene ID" value="UU417"/>
    </dbReference>
    <dbReference type="GeneID" id="29672589"/>
    <dbReference type="KEGG" id="uur:UU417"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.433"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_1_0_14"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="185"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="321" mass="37272" checksum="5CB8F679EE5934DB" modified="2000-10-01" version="1">MQKDLLTKLIEQTYGFNKITIFVHTNPDCDALGSAFALARILKLNTFGTRVKIVGVNALNPNDFKNFFTFDPNEVDDEFIKDSIAFIVDTANQERVLSQKHRLAKKTILVDHHVKTITYTDLEYINDQSIAACEMIAYSLMHTNLNFDLKTLNYLLLGITTDSNRLMYDKVSDFTYEIMSWFFKNNVKHYQIYQQLYERNLNDILFDNELVKTIKTQGQVAYLNIDPQWNQKYHFTRWGDKVYLLSNIKNYPIWFIVYFDENTNTYKVSLRSNKYKVRLVASQFNGGGHDLAAGCSLTNIDQLENLLSALDALIKNKIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ94</accession>
    <name>Q9PQ94_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688482.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU396"/>
    <dbReference type="EnsemblBacteria" id="AAF30806">
        <property type="protein sequence ID" value="AAF30806"/>
        <property type="gene ID" value="UU396"/>
    </dbReference>
    <dbReference type="GeneID" id="29672625"/>
    <dbReference type="KEGG" id="uur:UU396"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.411"/>
    <dbReference type="HOGENOM" id="CLU_2412335_0_0_14"/>
    <dbReference type="OMA" id="FFGMISQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="92" mass="10392" checksum="08C0AF0899509037" modified="2000-10-01" version="1">MQKISDNFKKVYYGGFSTSNSFNYMWNNALISSMLGQTVVGFLGMISQLVYAFNPQPKFNPQQMIDNSVARTYARIAQKPMNSTISLGTPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA0</accession>
    <name>Q9PQA0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689065.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU390"/>
    <dbReference type="EnsemblBacteria" id="AAF30800">
        <property type="protein sequence ID" value="AAF30800"/>
        <property type="gene ID" value="UU390"/>
    </dbReference>
    <dbReference type="GeneID" id="29672208"/>
    <dbReference type="KEGG" id="uur:UU390"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.405"/>
    <dbReference type="HOGENOM" id="CLU_1026512_0_0_14"/>
    <dbReference type="OMA" id="FFIVPFD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="271" mass="30788" checksum="363209395F7D4427" modified="2000-10-01" version="1">MNLKSFEFLKGDAIVDNQIKKAINTSLIKASFSCAIMCILVLIFGFLMRKYLFYFSDASSLIISSRLIFQIITIIVATLSIVYFIVHLIIYFRQRNNFLAPKFAWSIILYLLDGITMCFMISYVAAIVGLDLTLIAIGISLSIIVAMGILGFIMNHKIAFKLGIANIVLFTIATIGSIILLIVFFTTRYNHTGFNKGVIIADIVLSIIWLLALSIGFASTIYIIKVMAEHHNLDNKKIMRDFTTWNSYLLFASFNRILLYVIRLFLLFKRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-04-03" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA5</accession>
    <name>MRAZ_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name type="ordered locus">UU385</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891757.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQA5"/>
    <dbReference type="SMR" id="Q9PQA5"/>
    <dbReference type="STRING" id="273119.UU385"/>
    <dbReference type="EnsemblBacteria" id="AAF30795">
        <property type="protein sequence ID" value="AAF30795"/>
        <property type="gene ID" value="UU385"/>
    </dbReference>
    <dbReference type="GeneID" id="29672219"/>
    <dbReference type="KEGG" id="uur:UU385"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.400"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_0_14"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000108555" description="Transcriptional regulator MraZ">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 2" evidence="2">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <sequence length="145" mass="16565" checksum="CF06C0D7DA5A4DEF" modified="2000-10-01" version="1">MFIGTYNHSIDSKNRMLVPSKVKATLGEAIFVYLSLGFDGNIDMRLESEFNQFVNNINNLLIGSKEARNLTRLILSQTYKIEIDSASRILIPQNLIDKAKIKKDIYIIGTNDRYEIWAKEVYDDFSLNQESTLSDLAEKLLINGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB1</accession>
    <name>Q9PQB1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU379.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU379.1"/>
    <dbReference type="EnsemblBacteria" id="AAF30789">
        <property type="protein sequence ID" value="AAF30789"/>
        <property type="gene ID" value="UU379.1"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU379.1"/>
    <dbReference type="HOGENOM" id="CLU_2412334_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="92" mass="11157" checksum="27216D97FC5601A9" modified="2000-10-01" version="1">MKNWAKSLLIDFINIDFHNFKSIQIVLDAWTNQVFEVVDIINLSWYIRIKIKKGNTLEHYLFTKFFKGYFYYDQQSHHLISQKINVKKPLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB3</accession>
    <name>Q9PQB3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891753.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30787">
        <property type="protein sequence ID" value="AAF30787"/>
        <property type="gene ID" value="UU378"/>
    </dbReference>
    <dbReference type="GeneID" id="29672545"/>
    <dbReference type="KEGG" id="uur:UU378"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.392"/>
    <dbReference type="HOGENOM" id="CLU_517716_0_0_14"/>
    <dbReference type="OMA" id="DRDQYSQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004331067" evidence="2">
        <location>
            <begin position="29"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="546" mass="61663" checksum="E0325D01E7DEAEAC" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB8</accession>
    <name>Q9PQB8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU373"/>
    <dbReference type="EnsemblBacteria" id="AAF30782">
        <property type="protein sequence ID" value="AAF30782"/>
        <property type="gene ID" value="UU373"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU373"/>
    <dbReference type="HOGENOM" id="CLU_3376616_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="34" mass="4189" checksum="C461A0BEF4718C81" modified="2000-10-01" version="1">MSREQLEYLITDIFYEEILKRNNSKNLEEVVEKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-31" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC6</accession>
    <name>SYN_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="1">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnS</name>
        <name type="ordered locus">UU365</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688779.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQC6"/>
    <dbReference type="SMR" id="Q9PQC6"/>
    <dbReference type="STRING" id="273119.UU365"/>
    <dbReference type="EnsemblBacteria" id="AAF30774">
        <property type="protein sequence ID" value="AAF30774"/>
        <property type="gene ID" value="UU365"/>
    </dbReference>
    <dbReference type="GeneID" id="29672210"/>
    <dbReference type="KEGG" id="uur:UU365"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_14"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176473" description="Asparagine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <sequence length="454" mass="52314" checksum="8851BF08F7149DEE" modified="2000-10-01" version="1">MQLKIKEIFNQDYVKLEGQKIQIKAWVRSNRDSKKIGFLVLNDGSSLTNLQAVYRVDKIDNYEEIAAARMWAAVVIEGVIKLTPTAKQPLELEVLNAQILKQSDEDFLLSNNDLNLETLRLNAHLRPRTNLFHAIMKVRATLAFAVHEFMNQNEYSWLAAPLFTGNDAEGAGETFSIQKFDNEEFFGKQTHLSVTGQLQAEAYAQAFGNVYTFGPTFRAEKSHTNRHLAEFWMIEPEMAFVDLKGMQDIVEDLVKHVIKAVLEKNQQELEFLAQRNDENLIKKLQKVVESKFERIEYKDAVKILADAVKNGHQFENNEIFFGMDLGSEHERYMCETYHQGPVFLQNYPKDIKAFYMKLNDDQQTVASTDLLIPGVGELVGGSQREDSYEKLLKRCQELKMPIESLQWYLDLRRFGYYMSSGFGIGFERLVMYVTGVNNIKDTIPFPRSHGQIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD4</accession>
    <name>Q9PQD4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrate-dependent iron transport, membrane-bound protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fecD</name>
        <name evidence="8" type="ordered locus">UU357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688601.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU357"/>
    <dbReference type="EnsemblBacteria" id="AAF30766">
        <property type="protein sequence ID" value="AAF30766"/>
        <property type="gene ID" value="UU357"/>
    </dbReference>
    <dbReference type="GeneID" id="29672409"/>
    <dbReference type="KEGG" id="uur:UU357"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.371"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067576_0_0_14"/>
    <dbReference type="OMA" id="VFIWIVR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="356" mass="40556" checksum="A2A32CD7F559A82A" modified="2000-10-01" version="1">MQIKQVNINKKDLSIYKKLIEAKKFVSTQIRRPYMITIIVLTFIILAVGMFFMNVFYEKSTYFDANYNTHVTYFRTWAKVVADDKSILLYWYPPIVKLFVAISMPVAGYAIQITTQNRLSSPSTLGYIPVSILAYVAMLMIDQGKSWLVYVFGFIFSSFIILVNYILQRQKSSNRSFKPVLIGFAISATITAVGLVIAVSRPNILNRVTIWTGELPNVYEWLKLYISMPLILICLFAFLVLSPKLKIMQRDFALAKSLGIKVNLIFWVVTVLTAIVTIATVNITSPMILLGLIIPNIVRATFNKHEPLFVFFVSIVFSLALLEVSLFLSLNYRFGPNFLMAIVSAFVLIFIMRKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD6</accession>
    <name>Q9PQD6_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribF</name>
        <name evidence="13" type="ordered locus">UU355</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688419.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU355"/>
    <dbReference type="EnsemblBacteria" id="AAF30764">
        <property type="protein sequence ID" value="AAF30764"/>
        <property type="gene ID" value="UU355"/>
    </dbReference>
    <dbReference type="GeneID" id="29672375"/>
    <dbReference type="KEGG" id="uur:UU355"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.369"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_2_14"/>
    <dbReference type="OMA" id="VCETHIF"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="158"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAF30764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="283" mass="32769" checksum="E8372C5C84280F78" modified="2000-10-01" version="1">MIIEITSTNIYKIKQQFVINELIIGFFDGIHLGHMNLLSDPNNQTILTFKNIPRKIKKLYDFNERIQQLEDLGFKRIFIYDIDQNNLSGEEFIDQILKPLTPKKIIVGANFTYGNNFCNASSLKQYFNVEIKIITNDVSTTKIKELIINKQVEIANKLLIKPYYRVGNVVRGDQIARNIGFNTANILCDNNLIDIAEGVYKAQVIFNNKKYDSVVYLGIPKTINTRSFSMIEAHILDFNQNIYDERIKIVFLKYLAPNLKFNNIDELITAIKNYIKLVLDKTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD7</accession>
    <name>TRUB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="1">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truB</name>
        <name type="ordered locus">UU354</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688525.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQD7"/>
    <dbReference type="SMR" id="Q9PQD7"/>
    <dbReference type="STRING" id="273119.UU354"/>
    <dbReference type="EnsemblBacteria" id="AAF30763">
        <property type="protein sequence ID" value="AAF30763"/>
        <property type="gene ID" value="UU354"/>
    </dbReference>
    <dbReference type="GeneID" id="29672408"/>
    <dbReference type="KEGG" id="uur:UU354"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_2_0_14"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000121937" description="tRNA pseudouridine synthase B">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <sequence length="227" mass="25765" checksum="FA1CADC357D6AD36" modified="2000-10-01" version="1">MSAISKNIIIINKPIKWTSNDVVQKVKRVIGAKKVGHAGTLDPNASGVLVLGINEGTKLLTKLILDNKSYIAEIKFGTSTNTYDAAGEIVSSTNRMVTLTEVTKIVKDFYKNDYWQKPPQFSALKINGQKAYVLARQKVDFEIAPRLVKIFKYQIMDFNYEKQILKISLHVSKGFYVRSFAVDLATKINNLAHLLTLIRTQSGPFEIKDAIEIEQVYDYWNNINKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD8</accession>
    <name>Q9PQD8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU353"/>
    <dbReference type="EnsemblBacteria" id="AAF30762">
        <property type="protein sequence ID" value="AAF30762"/>
        <property type="gene ID" value="UU353"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU353"/>
    <dbReference type="eggNOG" id="ENOG502ZWZM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813643_0_0_14"/>
    <dbReference type="OMA" id="ELNIIMV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="304" mass="35685" checksum="A0A28F07E84C0D68" modified="2000-10-01" version="1">MRESFDAHIKKKSKILFYFMEWWFQTTNYKLNPEISHAKRSLRSWLIEIFFLFCIVALIVCILAGVARPIIDCVIKSITLSRGQFKGDLIIDGQIIMKNLSPSNINGLTGGSSILNVDQWELIPKVWKAYFSSPSVVVLILLVLFFLFFSCLYIYMIKKIRPRTNKMSLEDYLIARMNLINSFKFILKRKVLFIEGIKEYNHRFVFNMNADYNLMRIMNYIYSGLAELNIIMVIDMDSDEKIFELQKVIKQDFDNLDLIIIEKEIAESLKSKYQNGCLNKKTNLININNKEIDQSQQTQDINIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQD9</accession>
    <name>Q9PQD9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688721.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30761">
        <property type="protein sequence ID" value="AAF30761"/>
        <property type="gene ID" value="UU352"/>
    </dbReference>
    <dbReference type="GeneID" id="29672406"/>
    <dbReference type="KEGG" id="uur:UU352"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.366"/>
    <dbReference type="HOGENOM" id="CLU_2182822_0_0_14"/>
    <dbReference type="OMA" id="NWELCRE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="109" mass="13391" checksum="836E045597A04871" modified="2000-10-01" version="1">MCISKIDMAKVKKFFKEYLFAKFQCKNRELYRQLKDYDPKDDQKYLKWEHFVEYVEQVLEALDKTSAQIIKEIYIQNKRICELPYSYSTYYAYRKKAIIELLAYLDLKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE6</accession>
    <name>SCPA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Segregation and condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">scpA</name>
        <name type="ordered locus">UU345</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ScpA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQE6"/>
    <dbReference type="SMR" id="Q9PQE6"/>
    <dbReference type="STRING" id="273119.UU345"/>
    <dbReference type="EnsemblBacteria" id="AAF30754">
        <property type="protein sequence ID" value="AAF30754"/>
        <property type="gene ID" value="UU345"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU345"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_933651_0_0_14"/>
    <dbReference type="OMA" id="QIMSIEE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211121" description="Segregation and condensation protein A">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01805"/>
        </source>
    </evidence>
    <sequence length="294" mass="35019" checksum="73149C3E5523C8B3" modified="2000-10-01" version="1">MNRMSEKQIQNSLFEYKFIDFNGPLDTLCVLIKQKRLDINNLDILELSKQYVNFVNQLIKTIDIDILGDHLAMASYLLELKTRMLMPTVDEKQIMSIEEDRQNLIDRLIEYNGYKNLSEHLKQRFEFRATMMDLPQQDYEQFYLKDAIYKPLPNHLDSMILKNIMDKIIYENELKNYKINKIKVHEYDVKQLEQLLLNYLKQSPNQQASMLSFFDIQAVIDKNKRFFAIMFLIILILINRNEILFEELDNDYLLKINIERVVDDYNSSSVEQAKNLTSNLTKDTIINFKGEDNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF8</accession>
    <name>RL32_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmF</name>
        <name type="synonym">rpl32</name>
        <name type="ordered locus">UU333</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688693.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQF8"/>
    <dbReference type="SMR" id="Q9PQF8"/>
    <dbReference type="STRING" id="273119.UU333"/>
    <dbReference type="EnsemblBacteria" id="AAF30742">
        <property type="protein sequence ID" value="AAF30742"/>
        <property type="gene ID" value="UU333"/>
    </dbReference>
    <dbReference type="GeneID" id="29672474"/>
    <dbReference type="KEGG" id="uur:UU333"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_14"/>
    <dbReference type="OMA" id="CSCGMYG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000172432" description="50S ribosomal protein L32">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="57" mass="6541" checksum="FC56D0AD08BEECFF" modified="2007-01-23" version="3">MAVQQRRVSKSRKGMRRSHDHLTISNTVACNECGKALLPHRACRDCKTYRSIKLSIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH0</accession>
    <name>RBFA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name type="ordered locus">UU321</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688602.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQH0"/>
    <dbReference type="SMR" id="Q9PQH0"/>
    <dbReference type="STRING" id="273119.UU321"/>
    <dbReference type="EnsemblBacteria" id="AAF30730">
        <property type="protein sequence ID" value="AAF30730"/>
        <property type="gene ID" value="UU321"/>
    </dbReference>
    <dbReference type="GeneID" id="29672463"/>
    <dbReference type="KEGG" id="uur:UU321"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_3_2_14"/>
    <dbReference type="OMA" id="IYIDCLI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000102764" description="Ribosome-binding factor A">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <sequence length="116" mass="13247" checksum="A79DCC71F0547514" modified="2000-10-01" version="1">MANEVRVARLESLIKDVINNALANEINDKIAKLARVTAVRLSNDLSVAKIFLDAHKRESMLKVLENVNKVSGLLRSKLAAEWTSYKVPELRFVIDETIDYANHIDELFKKIKQQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH2</accession>
    <name>Q9PQH2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688432.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU319"/>
    <dbReference type="EnsemblBacteria" id="AAF30728">
        <property type="protein sequence ID" value="AAF30728"/>
        <property type="gene ID" value="UU319"/>
    </dbReference>
    <dbReference type="GeneID" id="29672450"/>
    <dbReference type="KEGG" id="uur:UU319"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.332"/>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2541617_0_0_14"/>
    <dbReference type="OMA" id="PKNELVR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="83" mass="10117" checksum="923ACBA37E72D2C0" modified="2000-10-01" version="1">MAMKVNERTCVFSKEKYPKDHLVRFVIINGELIFSLNYHRGYYLMIQKNTNIQKVCQFLKKRFMIKNEEQVYRILEQLIQSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH4</accession>
    <name>Q9PQH4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891731.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU317"/>
    <dbReference type="EnsemblBacteria" id="AAF30726">
        <property type="protein sequence ID" value="AAF30726"/>
        <property type="gene ID" value="UU317"/>
    </dbReference>
    <dbReference type="GeneID" id="29672453"/>
    <dbReference type="KEGG" id="uur:UU317"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.330"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256964_0_0_14"/>
    <dbReference type="OMA" id="NVIVPYY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1575" mass="182060" checksum="6A7B3C21D88AEFCC" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI4</accession>
    <name>Q9PQI4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688808.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU307"/>
    <dbReference type="EnsemblBacteria" id="AAF30716">
        <property type="protein sequence ID" value="AAF30716"/>
        <property type="gene ID" value="UU307"/>
    </dbReference>
    <dbReference type="GeneID" id="29672400"/>
    <dbReference type="KEGG" id="uur:UU307"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.320"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865849_0_0_14"/>
    <dbReference type="OMA" id="EDHAIEQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="316" mass="37138" checksum="CFC436A04DFAD903" modified="2000-10-01" version="1">MNNNQVDDELDLENFNYQKALEIPNIKAINLTEEEFNLYFWDIVEVYRSYLNNLNNQNDSYYIYQLNRNEYNHLCLVVVKKENKVDKIKRNYILNTIKNMDYNISLADDSQIFSKKTEILDANLLAERNKLINFFLEEARKNKKNTLIKNNNQQPKSAFIYGDFSVGKSIITQAYTNTISLKYNLKIAYITLNDLFKNVIQFFNYKDTSDLVINELVNLLSNVDVLVIDDFSSVNLNYWSISTILMPIIENRLKSTRQTIFISNFSIEQLINSTKNTTNIEEQKTKLRLFNRIEYLTYGNIFKITGPSVFKVVNNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-07-26" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ4</accession>
    <name>RECU_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Holliday junction resolvase RecU</fullName>
            <ecNumber evidence="2">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Recombination protein U homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">recU</name>
        <name type="ordered locus">UU297</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecU family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891726.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQJ4"/>
    <dbReference type="SMR" id="Q9PQJ4"/>
    <dbReference type="STRING" id="273119.UU297"/>
    <dbReference type="EnsemblBacteria" id="AAF30706">
        <property type="protein sequence ID" value="AAF30706"/>
        <property type="gene ID" value="UU297"/>
    </dbReference>
    <dbReference type="GeneID" id="29672508"/>
    <dbReference type="KEGG" id="uur:UU297"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.309"/>
    <dbReference type="eggNOG" id="COG3331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096340_2_0_14"/>
    <dbReference type="OMA" id="TDYNGIY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00130">
        <property type="entry name" value="RecU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004612">
        <property type="entry name" value="Resolv_RecU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03838">
        <property type="entry name" value="RecU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000212320" description="Holliday junction resolvase RecU">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="170" mass="20527" checksum="892315A8C36933DD" modified="2000-10-01" version="1">MNNKNNGMHLEVLINKSISLFNLQYQAFFKKRCVDIIIKNIDNSYVQGKIKQKSETDYYGFYKGDYFDFEAKQTNKNSFLIKQIQPHQLAHLYLIHKNSGFSFLIICFINYNLYFIITFQQLINYYQKTKRKSIPFQWFKDQCIELEIIFPGVINFKKMINDLKLKYYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ7</accession>
    <name>Q9PQJ7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU294"/>
    <dbReference type="EnsemblBacteria" id="AAF30703">
        <property type="protein sequence ID" value="AAF30703"/>
        <property type="gene ID" value="UU294"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU294"/>
    <dbReference type="HOGENOM" id="CLU_086999_0_0_14"/>
    <dbReference type="OMA" id="IYTKTFY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="201" mass="24440" checksum="70FECCF08ABCFFBA" modified="2000-10-01" version="1">MIQKAKFYAGYISRLRFIQKLRYEIQNEKKTLNKIIKVVNDADISTLYDFKDKNLTIYTKTFYFHNYQFVNANKKNYFISKKTIKSVITENLLDIGFTWTIIYNDQTKTYIRPTDFMTKNFIDYKKNENKIATRSKILYDMIVKNESLNINHSEYESLLVNNEWKRYYENMINIFLYQYYNEGIKNDIDFLNHFLLKDALK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-02" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK2</accession>
    <name>MSRA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="1">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="1">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="1">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrA</name>
        <name type="ordered locus">UU289</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688929.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQK2"/>
    <dbReference type="SMR" id="Q9PQK2"/>
    <dbReference type="STRING" id="273119.UU289"/>
    <dbReference type="EnsemblBacteria" id="AAF30698">
        <property type="protein sequence ID" value="AAF30698"/>
        <property type="gene ID" value="UU289"/>
    </dbReference>
    <dbReference type="GeneID" id="29672509"/>
    <dbReference type="KEGG" id="uur:UU289"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_14"/>
    <dbReference type="OMA" id="GYCAFVV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138606" description="Peptide methionine sulfoxide reductase MsrA">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <sequence length="165" mass="19341" checksum="678DC470BBE22AAD" modified="2000-10-01" version="1">MIKSIWIAGGCFWGIQKYFDSIIGVNHTVVGYSQGNVINPSYEQVCTQTTNHTETVQIDYDDRFVSLISILEHLYQIIDPFSLNKQGDDVGSQYRSGIYYVDHDDEFIIKDFLLKKQNQTPKKIMIEVERLRNFNIAEEYHQKYLDKNPNSYCHVDLSLSKKEFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-06-16" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQK6</accession>
    <name>SYH_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">UU285</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688869.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQK6"/>
    <dbReference type="SMR" id="Q9PQK6"/>
    <dbReference type="STRING" id="273119.UU285"/>
    <dbReference type="EnsemblBacteria" id="AAF30694">
        <property type="protein sequence ID" value="AAF30694"/>
        <property type="gene ID" value="UU285"/>
    </dbReference>
    <dbReference type="GeneID" id="29672568"/>
    <dbReference type="KEGG" id="uur:UU285"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_14"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136289" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="420" mass="48763" checksum="6BBC515389F8BBFD" modified="2000-10-01" version="1">MINYSKPRGTIDLYNKEMNDFKLLENFLLSTTKRYGFQQIKTPVFEFAELFMKSAGESSDLVSKEMYLFKDKSDRWLALRPEGTAGVIRAVVENKLLLNHPLPLKLMYFEPCFRYERPQAGRQRQFHQFGVEVLGTKNIYYDFELIALADTILKKLMISNYILEINYISSPHNRSLWVKSLQEYFHLHRTELTPLSQERITTNPLRILDDKLESQKLVVKQAPKISHFLSNEEKEEFNLIKKMLDDYNIKYYVNEGLVRGLDYYSGLVFEFISTSPKLLGQSTIIGGGRYGELIKQTGGPNYEGIGFGIGIERLLIALSETNKNILNTDDDKYLIAFFDKELENEAIKLTQILRINNQLNVDIILSSTKADKIFKLAQRLNVKKLIILAKKEWSDKKIILKDLLNFKQDLLSLDEIKGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL5</accession>
    <name>Q9PQL5_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">UU276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688913.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU276"/>
    <dbReference type="EnsemblBacteria" id="AAF30685">
        <property type="protein sequence ID" value="AAF30685"/>
        <property type="gene ID" value="UU276"/>
    </dbReference>
    <dbReference type="GeneID" id="29672510"/>
    <dbReference type="KEGG" id="uur:UU276"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.286"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_1_0_14"/>
    <dbReference type="OMA" id="EVRWTLD"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01571">
        <property type="entry name" value="NAPRTase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035809">
        <property type="entry name" value="NAPRTase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="363" mass="41227" checksum="6158320DEA64EFE8" modified="2000-10-01" version="1">MGPIIPNTRLIDFKFDRDLLNSAYTAHYFIKTCKIIELHAPNHSVIMQFTHFSKTPIMVCGTSEVLALLEFCLSKKELKQLKIYYVPDGHVIKPKEALFVIEGPYEIFGWLENIIDSILARRSSIATNCYNVLNLINDEQKVIYMSDRSDDYSLQPYDGYAAAVGGMQYFVTQKQVEFLKDINYECKVIGSMPHALIQQNNGRIDLACEMFAQTFPSDPLIAVIDYNNNVLNDLEQLRYMFDRLFAVRIDTAKDLIDESLLSTFNNVGNRDLHGCNPYLIALVREYLDNNGGKHIKIIASSGIDLNGIKNFNKHNSAIDFYGIGTYLSHLSVHITADLVCLDNVYGAKVGRKIAKNFSEMILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM0</accession>
    <name>Q9PQM0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU271"/>
    <dbReference type="EnsemblBacteria" id="AAF30680">
        <property type="protein sequence ID" value="AAF30680"/>
        <property type="gene ID" value="UU271"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU271"/>
    <dbReference type="HOGENOM" id="CLU_598440_0_0_14"/>
    <dbReference type="OMA" id="IYDASPQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="457" mass="54662" checksum="69657AFCD3488488" modified="2000-10-01" version="1">MFMFDQIFKKRKRHLNFQIFIFFFVLILITFLILWIISGNVQTIIDFIKKKIYDASPQLKYLTNIQIKPFKNLEEIFDFIIKNKNLIKDLQNEPEILDVIKNNPQILKTLNDNREFLKQIVEYKPFAEILSKQPEILKFVQNNKELIKQIQNLPELLDLIKKHQNLIDHLKTNEKYIEVIKANPQMLKDLYHVDDNLFNIIKTSLENDKENNILMLAIKYSVLINNFTKNLTLQEWKQIIEFYKTVDLNKFIVDDNLFNIIKNNNQLFEVFLNNYDYIKNLEDNQKIIDIIQQNPDLIDDFKKIDFDLLTQKRNFVRALIKIIDYKQPKEIQFLNKKVFLDFFKNKSEITNALNITSLIGFVLFIVIYTIFIFASFISHILMLKQIKDFNKIFKEAKLKKIYLISTLLLQFLFLILFIINFIVLIILVVDYNKLKAIVLNSGIKRKVEDSDARLHFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM5</accession>
    <name>ENGB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">engB</name>
        <name type="ordered locus">UU266</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688825.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQM5"/>
    <dbReference type="SMR" id="Q9PQM5"/>
    <dbReference type="STRING" id="273119.UU266"/>
    <dbReference type="EnsemblBacteria" id="AAF30675">
        <property type="protein sequence ID" value="AAF30675"/>
        <property type="gene ID" value="UU266"/>
    </dbReference>
    <dbReference type="GeneID" id="29672535"/>
    <dbReference type="KEGG" id="uur:UU266"/>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_14"/>
    <dbReference type="OMA" id="LMMDIRH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000157796" description="Probable GTP-binding protein EngB">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EngB-type G" evidence="1">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="52"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <sequence length="208" mass="23968" checksum="B21900E3DB8EEF12" modified="2000-10-01" version="1">MAKFIKSAHYFDQYPIDKQFEICVIGRSNVGKSSLINALANKKIARTSNTPGRTQLVNFFDFNNFRLVDLPGYGFAKVSKEKQTDLAAIIDQYLGYRQNLCAVFQICDINVLTNDDVEMSRYFENQKYAHFVVLNKLDKVNKSYFNNNKHKIAKFLNISTDRLLCVSAQNNINIITLFALMKKVVIQAKQEKILSKKEEKMSSEEEIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-02-28" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN5</accession>
    <name>RS11_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsK</name>
        <name evidence="1" type="synonym">rps11</name>
        <name type="ordered locus">UU256</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026006.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQN5"/>
    <dbReference type="SMR" id="Q9PQN5"/>
    <dbReference type="STRING" id="273119.UU256"/>
    <dbReference type="EnsemblBacteria" id="AAF30665">
        <property type="protein sequence ID" value="AAF30665"/>
        <property type="gene ID" value="UU256"/>
    </dbReference>
    <dbReference type="GeneID" id="45015800"/>
    <dbReference type="KEGG" id="uur:UU256"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_14"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000123252" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <sequence length="121" mass="12703" checksum="A3A2B056E8C1BC59" modified="2000-10-01" version="1">MAKKKKLSFTNGIAYIHATKNNTIITLADEQGSVLSWASSGSIGYKGTKKKTPYSAGIAAEAAAKAVIDMGLKSVEVHVNGTGASRDTAIRSLQAAGLEVTKIKDVTPIPHNGCRPPKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP1</accession>
    <name>Q9PQP1_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ordered locus">UU250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689109.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU250"/>
    <dbReference type="EnsemblBacteria" id="AAF30659">
        <property type="protein sequence ID" value="AAF30659"/>
        <property type="gene ID" value="UU250"/>
    </dbReference>
    <dbReference type="GeneID" id="29672605"/>
    <dbReference type="KEGG" id="uur:UU250"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.259"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_1_14"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAF30659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="471" mass="51716" checksum="07EF024469E6B1F1" modified="2000-10-01" version="1">MTNKQKKKNAFRQLLMIFKNKKVLVALIVTLSILILFRIGSVIPMPYIKLNGNFGNQGSFFSIINLLGGGGLSQFSLFAIGIGPYITAQIIMQLLSSELVPPLAKLSKSGERGRKKIEVITRIITLPLAVMQAVIIINLMTRANGFISIVSNAPFAIGSPLFYVTYIFLMVGGTYISLFLADLISKKGVGNGITLLILTGIVASLFNHFIAIFSNLGSLTSSKVSQIIGFILYILFYIMILIGVVFVNNSTRKIPVQQTGQALILDHEKLPFLPIKIMTAGVMPVIFASSVLAIPAQVAEFLDKQSMGYYVIHNYFIVDSWTGLAIYVVLILLFTFFFSYVQLNPPKMAEDIKKAGRFIPGVQVGMDTEKHITKVIYRVNWIGAPILAFLACLPHLVALVAKTINHGIPVIQPSTIFGGTSIIIMVTATLELWNAIKSTSTSTSYAYQRKELETSITVSAESDKSSKSQIW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-12-06" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP3</accession>
    <name>RS5_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name evidence="1" type="synonym">rps5</name>
        <name type="ordered locus">UU248</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688963.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQP3"/>
    <dbReference type="SMR" id="Q9PQP3"/>
    <dbReference type="STRING" id="273119.UU248"/>
    <dbReference type="EnsemblBacteria" id="AAF30657">
        <property type="protein sequence ID" value="AAF30657"/>
        <property type="gene ID" value="UU248"/>
    </dbReference>
    <dbReference type="GeneID" id="29672677"/>
    <dbReference type="KEGG" id="uur:UU248"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_1_14"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131626" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="203" mass="22222" checksum="718C36E582B41986" modified="2000-10-01" version="1">MENNVKKETIVDSEKVEKQQLVTAPVVNKKENTEPKAKTFKRETTTSNFEERVVKIKRISKTTKGGRMMRFSALVVIGDKNGTVGFGMGKSIEVPDAIKKAIKNANNNLIKVKQTKKGSIYHDVNGRHGAAKVMLLPAPEGTGIIAGGPVRAVVELAGFTDIYTKSRGANAPMNVIRATINGLLQQLTPKEIARLRDKSLREI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ5</accession>
    <name>RL22_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rplV</name>
        <name type="synonym">rpl22</name>
        <name type="ordered locus">UU236</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688968.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ5"/>
    <dbReference type="SMR" id="Q9PQQ5"/>
    <dbReference type="STRING" id="273119.UU236"/>
    <dbReference type="EnsemblBacteria" id="AAF30645">
        <property type="protein sequence ID" value="AAF30645"/>
        <property type="gene ID" value="UU236"/>
    </dbReference>
    <dbReference type="GeneID" id="29672595"/>
    <dbReference type="KEGG" id="uur:UU236"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4933">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894135_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125257" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="311" mass="35389" checksum="803179960C35D871" modified="2008-11-25" version="3">MTNKVIQRNIHISHRKASLVIDLVRNKPVHEAIRILSNTPKKFAPIVLKLLNSAISNVQHNSKDMDPSKLYIYKIVANQGPTMKRTLPRAKGSADQLFKRTTHLEIVLSDDVNEREKELAAIKAKKSKKPLAVEPIAKVETKKVAKPSKVEIKPVEKDENVDPELLKREQQVLKVVEKTASQKEEETTETIMISTSPKNAQVLFDDLEKNVIFYKTTPINKVLRVLVYVTSPTKKVVGEFDLESVEIGAISSIWRKYSKQSVISKKEYDAYYEGKDKAHALVSKKAYKYRNPKDLSEYNMTKGPSGFQYLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-02-16" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR0</accession>
    <name>RL3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplC</name>
        <name evidence="1" type="synonym">rpl3</name>
        <name type="ordered locus">UU231</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688934.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQR0"/>
    <dbReference type="SMR" id="Q9PQR0"/>
    <dbReference type="STRING" id="273119.UU231"/>
    <dbReference type="EnsemblBacteria" id="AAF30640">
        <property type="protein sequence ID" value="AAF30640"/>
        <property type="gene ID" value="UU231"/>
    </dbReference>
    <dbReference type="GeneID" id="29672579"/>
    <dbReference type="KEGG" id="uur:UU231"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_0_14"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000077185" description="50S ribosomal protein L3">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <sequence length="233" mass="24994" checksum="7D88AC1A6F91A185" modified="2000-10-01" version="1">MKSLLGTKVGMTQVFTETGKAVAATVIYVEPNKVLAVKTNEKDGYSAIQIGYETVKEKALNKPLLGQFKKANSDPKRHIKEFRDVVAEVGAELTVSEFEPGQLVNAQAYTKGHGFTGSIKRHNFSMGPMGHGAGYPHRYVGSIAKGRGGSQAQRVFKGTKLPGHYGHELVTTKNLLVLDVKANENLILIKGAIPGPKGSIVLLKSAKKVGHIVSDPQVVNYLANKASSSEANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR5</accession>
    <name>Q9PQR5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU226"/>
    <dbReference type="EnsemblBacteria" id="AAF30635">
        <property type="protein sequence ID" value="AAF30635"/>
        <property type="gene ID" value="UU226"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU226"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526693_0_0_14"/>
    <dbReference type="OMA" id="NTNKARI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="525" mass="58871" checksum="AE86E6FC9C1AC0BB" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-22" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS0</accession>
    <name>XER_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine recombinase UU222</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xerC</name>
        <name type="ordered locus">UU222</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688953.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQS0"/>
    <dbReference type="SMR" id="Q9PQS0"/>
    <dbReference type="STRING" id="273119.UU222"/>
    <dbReference type="EnsemblBacteria" id="AAF30630">
        <property type="protein sequence ID" value="AAF30630"/>
        <property type="gene ID" value="UU222"/>
    </dbReference>
    <dbReference type="GeneID" id="29672591"/>
    <dbReference type="KEGG" id="uur:UU222"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093495_0_0_14"/>
    <dbReference type="OMA" id="YRRTNIM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0229">DNA integration</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000095343" description="Tyrosine recombinase UU222">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A8P8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30630.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="30189" checksum="20C74B7659496F60" modified="2000-10-01" version="1">MKDFIRYTKKRNLSLNTIRTYESVLKHYEPVLDSWIKIRNKIINSNFKPRTIHLHKNVLLSFFEFKKLKRYLQNLKLLKLPQIEMKYFDVISKNNLYKKTDILDDDSLEIKKYKTIIRFLFETGIRAHELFFLESINNRLYVLGKGNKKRQIFFVKQTFEQLQKFYENLKGFETTKTLRLYIKKIIGKNFTPHSLRRSFATFMLIKGANPKTVMLQMGHANIQTTFSYLNLNEQTNRRIYNKIMYQNDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS2</accession>
    <name>Q9PQS2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688943.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU220"/>
    <dbReference type="EnsemblBacteria" id="AAF30628">
        <property type="protein sequence ID" value="AAF30628"/>
        <property type="gene ID" value="UU220"/>
    </dbReference>
    <dbReference type="GeneID" id="29672688"/>
    <dbReference type="KEGG" id="uur:UU220"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.228"/>
    <dbReference type="HOGENOM" id="CLU_633042_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="428" mass="50190" checksum="235D9B6FE52523A3" modified="2000-10-01" version="1">MPRINTQVFNENNDKNRIKSNNNKICDDIEYTRLLETKEYNAGFSPNNDSQDILIKKQDNILKLKPTLNFDDSDQLISIVPTKNYENLRLKEIEIDKKNTVDYQLKKEIIDQDLTDDNHLSISQKSNGFALKTKQFIPQNISEFIYHNEDDPKTYGSENNLTFSQLEEKVNQKNTPDFYLKEIHAVRNKIIIWTILLAIGVGLIFYLIYEVIINHFNPWIFLPISIYCVLMIFFLALSCSNFINFKKEMDYQKNHFDCTKATNFIVGIYRKLIVVHINVNWITAYIYLTSLFMIFGVFVVSYFMNLYYNAAIGSRFGDLIIKIPVVINNHLSQKISFNKNPLWAMIGLGAILGLTFIIHLWLVFNAHHRINRIHSYYVNEIITSEEIISLKKQANRRGLVIFLVLTVILGLIFYLMYTILKRKYTIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT3</accession>
    <name>RL28_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmB</name>
        <name type="synonym">rpl28</name>
        <name type="ordered locus">UU209.1</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026215.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQT3"/>
    <dbReference type="SMR" id="Q9PQT3"/>
    <dbReference type="STRING" id="273119.UU209.1"/>
    <dbReference type="EnsemblBacteria" id="AAF30617">
        <property type="protein sequence ID" value="AAF30617"/>
        <property type="gene ID" value="UU209.1"/>
    </dbReference>
    <dbReference type="GeneID" id="29672570"/>
    <dbReference type="KEGG" id="uur:UU209.1"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_2_14"/>
    <dbReference type="OMA" id="QKVRIMV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178583" description="50S ribosomal protein L28">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="64" mass="7164" checksum="72A6249D6BA7EDC6" modified="2000-10-01" version="1">MAKRDQLTGKGPLSGNTRSHAMNHSKRRWNVNLQKATIKTENGSQRVLVSAKTLKTLKKHNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT5</accession>
    <name>Q9PQT5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688901.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU208"/>
    <dbReference type="EnsemblBacteria" id="AAF30615">
        <property type="protein sequence ID" value="AAF30615"/>
        <property type="gene ID" value="UU208"/>
    </dbReference>
    <dbReference type="GeneID" id="29672628"/>
    <dbReference type="KEGG" id="uur:UU208"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.215"/>
    <dbReference type="HOGENOM" id="CLU_2468150_0_0_14"/>
    <dbReference type="OMA" id="QNRFVIK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="88" mass="10074" checksum="E950A8CBA9B417C0" modified="2000-10-01" version="1">MLKKTKFDTQLVKSLITSSILKVPGIFSVDINDKLSDFNRNYFVIKIDLHEDVVNVLSVANEARNLVYYELSKQLNDDNVVINIIINC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV8</accession>
    <name>PFKA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable ATP-dependent 6-phosphofructokinase</fullName>
            <shortName>ATP-PFK</shortName>
            <shortName>Phosphofructokinase</shortName>
            <ecNumber>2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pfkA</name>
        <name type="ordered locus">UU185</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphofructokinase type A (PFKA) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689121.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQV8"/>
    <dbReference type="SMR" id="Q9PQV8"/>
    <dbReference type="STRING" id="273119.UU185"/>
    <dbReference type="EnsemblBacteria" id="AAF30592">
        <property type="protein sequence ID" value="AAF30592"/>
        <property type="gene ID" value="UU185"/>
    </dbReference>
    <dbReference type="GeneID" id="29672722"/>
    <dbReference type="KEGG" id="uur:UU185"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_14"/>
    <dbReference type="OMA" id="MNTIMEC"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112004" description="Probable ATP-dependent 6-phosphofructokinase">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="321" mass="36542" checksum="3087C6061E9F546C" modified="2000-10-01" version="1">MNQVNFLNLDKNILIITSGGDAPGMNASLISLIHRLMNNNFNVFIGIEGLLGLYNNLIEPIKDKRVFDVYFNEQGTVIKTSRFIKLDINDKKTQIIKDNLLSHNIQKIIILGGQGSMQAGLVLTKMGFEVFGILHTIDNDFSETQMCIGALSAASFNQKLLKCLNYTAKAHCAFNLVELMGRECSWLVNNSVGKLKPILMLTNQDNKYTVDEVIDLIKDKINSIKEYDPLIIVQELIYDQKWYELLVKTFEQKLHKSLRITILNYLQRGAPVSDFDLQLAKDSANVLVDFIVNQNDIKNTNNMYVVINKFDNKLEVIKFNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-12-15" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW2</accession>
    <name>TPIS_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name type="ordered locus">UU181</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688831.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW2"/>
    <dbReference type="SMR" id="Q9PQW2"/>
    <dbReference type="STRING" id="273119.UU181"/>
    <dbReference type="EnsemblBacteria" id="AAF30588">
        <property type="protein sequence ID" value="AAF30588"/>
        <property type="gene ID" value="UU181"/>
    </dbReference>
    <dbReference type="GeneID" id="29672714"/>
    <dbReference type="KEGG" id="uur:UU181"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_14"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000090311" description="Triosephosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <sequence length="238" mass="26978" checksum="4F804DEE27D52A8B" modified="2000-10-01" version="1">MKYIIANFKMNATQELINHFLNNLTLFDEQKIIIGLAPGDLYLKTFVNLAEIKKVNLYAQNPSLHNKGPYTGQISCLQLLDINIKNALVGHSEIRIDFSQSIIDQKIKISMDLLEQVIICVGETFDAYKQNKSLNFVLNQLANIINYKGLKKIIIAYEPIWAIGTDLELDFKHINYMIEGIKTYLYNCTGINIPILYGGSVNDNNINELCNQKLIDGFLIGNASLDVNVFNKIIDKCK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX0</accession>
    <name>Y173_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU173</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU173</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To M.genitalium MG366 and M.pneumoniae MPN544.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688829.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQX0"/>
    <dbReference type="STRING" id="273119.UU173"/>
    <dbReference type="PRIDE" id="Q9PQX0"/>
    <dbReference type="EnsemblBacteria" id="AAF30580">
        <property type="protein sequence ID" value="AAF30580"/>
        <property type="gene ID" value="UU173"/>
    </dbReference>
    <dbReference type="GeneID" id="29672736"/>
    <dbReference type="KEGG" id="uur:UU173"/>
    <dbReference type="eggNOG" id="COG2251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402679_0_0_14"/>
    <dbReference type="OMA" id="ANTECLK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000210569" description="Uncharacterized protein UU173">
        <location>
            <begin position="1"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="690" mass="81367" checksum="AAA4563DE201CDD4" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX7</accession>
    <name>Y166_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU166</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU166</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQX7"/>
    <dbReference type="STRING" id="273119.UU166"/>
    <dbReference type="PRIDE" id="Q9PQX7"/>
    <dbReference type="EnsemblBacteria" id="AAF30573">
        <property type="protein sequence ID" value="AAF30573"/>
        <property type="gene ID" value="UU166"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU166"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.173"/>
    <dbReference type="HOGENOM" id="CLU_275327_0_0_14"/>
    <dbReference type="OMA" id="LATIQPC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220824" description="Uncharacterized protein UU166">
        <location>
            <begin position="1"/>
            <end position="944"/>
        </location>
    </feature>
    <sequence length="944" mass="107924" checksum="B5755E0CC99B8274" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY2</accession>
    <name>Y162_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU162</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU162</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
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            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQY2"/>
    <dbReference type="STRING" id="273119.UU162"/>
    <dbReference type="EnsemblBacteria" id="AAF30568">
        <property type="protein sequence ID" value="AAF30568"/>
        <property type="gene ID" value="UU162"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU162"/>
    <dbReference type="HOGENOM" id="CLU_598441_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220820" description="Uncharacterized protein UU162">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="457" mass="51904" checksum="57D0EFC8D0A4D637" modified="2000-10-01" version="1">MNNRLLLSVEEYLSLFPLIVRNENLEDNQLQLERKKQALTTFILRAQSMIDDCVASNGGAGFIYSWFDDLKTTDYQKTKFKEAIATLTNYLWLQGHFIDKDYTSAIGDGLSLSFKSENADFEKKRLDIINKLRVCGLYKKSKFANFNDDGIYVNYDELKINAINNVHEELRDHYISKNNPVVNNNFDLNHHNINNVSSINASGNLATLNGFILNDCTLPNDLTTDKSNKVYDNAIANYVDIHDVKNLAWYGQNNNNAITRQELYEYCNKINSKMYWDAIYDYKAGELVYDLDEKTNTIKVYKALVNNGVSTHNIVDPSKQINENVWELINIQQIDLNKIKEGVQDAVDNKVNEVKKAIDTKENTFTKNLENKVNEAKQAVLSSYEQDKASGVFKGEKGEPGIQGPIGPKGETGPKGEKGDSANVDALTSNLESFKNTALNRNVRFPWKIMDNLNKII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY7</accession>
    <name>Y157_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU157</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891691.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQY7"/>
    <dbReference type="STRING" id="273119.UU157"/>
    <dbReference type="PRIDE" id="Q9PQY7"/>
    <dbReference type="EnsemblBacteria" id="AAF30563">
        <property type="protein sequence ID" value="AAF30563"/>
        <property type="gene ID" value="UU157"/>
    </dbReference>
    <dbReference type="GeneID" id="29672682"/>
    <dbReference type="KEGG" id="uur:UU157"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.163"/>
    <dbReference type="HOGENOM" id="CLU_1229473_0_0_14"/>
    <dbReference type="OMA" id="VVKMNKV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220816" description="Uncharacterized protein UU157">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <sequence length="225" mass="26182" checksum="24D22FCC550F2352" modified="2000-10-01" version="1">MNKWVIGIDLSTTITGVAILRNEQIIKTFAVAFDNFNEKNLYNNVIRLIKEINLNVWLLADDDYYIGIEVANFSNPKLTQRFSIYAGMIIALMSQVLRDFNAEFKMFNANAWQLKIPQIQYNTLRKDRKLITKNLMIKTFNIKSNLNEDEYDALAIAYFYDSINSTLEQEEITKAKKIVKMNKVKQQLSISKKINKLLEKKSKLKKATAISKVDEQIEELKKLNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQZ7</accession>
    <name>Y147_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU147</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU147</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQZ7"/>
    <dbReference type="STRING" id="273119.UU147"/>
    <dbReference type="EnsemblBacteria" id="AAF30553">
        <property type="protein sequence ID" value="AAF30553"/>
        <property type="gene ID" value="UU147"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU147"/>
    <dbReference type="HOGENOM" id="CLU_2995407_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220806" description="Uncharacterized protein UU147">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <sequence length="57" mass="6987" checksum="9A72EC5DD476B3A8" modified="2000-10-01" version="1">MNYILNKNKKVSLTELMNQQPHWYLEELQEHLIKYLDTNGLNDTKKLIKQTIKEWKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR00</accession>
    <name>Y144_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU144</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU144</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891686.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR00"/>
    <dbReference type="STRING" id="273119.UU144"/>
    <dbReference type="PRIDE" id="Q9PR00"/>
    <dbReference type="EnsemblBacteria" id="AAF30550">
        <property type="protein sequence ID" value="AAF30550"/>
        <property type="gene ID" value="UU144"/>
    </dbReference>
    <dbReference type="GeneID" id="29672279"/>
    <dbReference type="KEGG" id="uur:UU144"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.150"/>
    <dbReference type="HOGENOM" id="CLU_1234565_0_0_14"/>
    <dbReference type="OMA" id="IALNNDN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220804" description="Uncharacterized protein UU144">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <sequence length="243" mass="27866" checksum="B3107AB7BA1925E3" modified="2000-10-01" version="1">MSLHKTIYIKFNNRDYDVKLTNVKIANIALNNDNVNNIEQNHISFRHLSTNDIKNSNDKVEAKFSIGLGFDISEKLKNIAFKKLDTNTNKLIDISDPTILRLTFYEYNKDQKVENNLAAPTDKTKISVVEIKKSQLMNSSIVSFVKKLNKNAKYHMANIAFNQQLLPYLNKQFNVNADFPIDLEQNPIDFNDNKQANDEKIKKTKESAIKVATAIAKQIVGIDYKGRDIIKNFIELDNVVNKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR05</accession>
    <name>Y139_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU139</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU139</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688826.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR05"/>
    <dbReference type="STRING" id="273119.UU139"/>
    <dbReference type="EnsemblBacteria" id="AAF30545">
        <property type="protein sequence ID" value="AAF30545"/>
        <property type="gene ID" value="UU139"/>
    </dbReference>
    <dbReference type="GeneID" id="29672155"/>
    <dbReference type="KEGG" id="uur:UU139"/>
    <dbReference type="HOGENOM" id="CLU_1175028_0_0_14"/>
    <dbReference type="OMA" id="IQMSAIN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220803" description="Uncharacterized protein UU139">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <sequence length="236" mass="28298" checksum="8EF3E6F2FE33B335" modified="2000-10-01" version="1">MDEQIFIQLLENNLTNSKSYVTQPIILEFKTDVFLIINQILKQYKKGKIIKNNTNEIILEIDNKLISITNLDINKFHSYQIVNINENKNIYNERNSLILFDLVNYIIEKNQNSIRHINFWTIQMSVVNWIYFITYNFNNSYLIDPNWKKYVFKIKKDESKGVISTNLLHNYGFVDFVVQSKSQNFLKAYRVQDEILKSVLNLGDNLNNEFLEEIMRKYDTYKIIDRDHKYLVINIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR06</accession>
    <name>Q9PR06_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical-cytochrome b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU138"/>
    <dbReference type="EnsemblBacteria" id="AAF30544">
        <property type="protein sequence ID" value="AAF30544"/>
        <property type="gene ID" value="UU138"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU138"/>
    <dbReference type="HOGENOM" id="CLU_1730632_0_0_14"/>
    <dbReference type="OMA" id="FFIQMGM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="151" mass="17715" checksum="0D01DC183F1B41BB" modified="2000-10-01" version="1">MNLKRMINSYLIIFLPFLSVSFVVFVFLGILLEASWSFFYSYLLVIPFGFGITLLRIFIISKLLNKRLKMNNLGVNPKKYRRLPANFFAFGTIYILFNFLILVPLIIGNLVNLYQSIFETISLFVLTFFMFFIQMGMQIYLGIKKDKGEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR17</accession>
    <name>Y127_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU127</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU127</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688845.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR17"/>
    <dbReference type="SMR" id="Q9PR17"/>
    <dbReference type="STRING" id="273119.UU127"/>
    <dbReference type="EnsemblBacteria" id="AAF30533">
        <property type="protein sequence ID" value="AAF30533"/>
        <property type="gene ID" value="UU127"/>
    </dbReference>
    <dbReference type="GeneID" id="29672754"/>
    <dbReference type="KEGG" id="uur:UU127"/>
    <dbReference type="HOGENOM" id="CLU_2290465_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220801" description="Uncharacterized protein UU127">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="101" mass="11720" checksum="00A9C79C559E7FF6" modified="2000-10-01" version="1">MKIIGSAFLGIVFCILLAFAIIFGIEIDYYHQGDYLKYLNFLDKLHQYNKIDNSFEYSNHYESALIGVIVLTIICFLIFITPIIIIVITKIKEKKVINKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR20</accession>
    <name>Q9PR20_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoU-1</name>
        <name evidence="3" type="ordered locus">UU124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689126.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU124"/>
    <dbReference type="EnsemblBacteria" id="AAF30530">
        <property type="protein sequence ID" value="AAF30530"/>
        <property type="gene ID" value="UU124"/>
    </dbReference>
    <dbReference type="GeneID" id="29672195"/>
    <dbReference type="KEGG" id="uur:UU124"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.130"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_14"/>
    <dbReference type="OMA" id="GASQYVK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="239" mass="27192" checksum="2AF8DA2093AD9781" modified="2000-10-01" version="1">MNYNFGKKALLDAIGNKQSISKVYLLSKNYELINLINKNKITYEIVNEAWFKQFDHSLNHQNIAFKLVKKNFQKTSLESFLKLIKDKKNALVLILDEIEDPRNFGAIIRTANGFGVDAIIYKKHHQASINDLVIKTSMGAINYIYMIEVNNLSNTIKNLQDEGFWVYATSLLKSQPYEKVDYANKTVFIVGNENKGVSPLILKNADQSIRIDMFGDVQSLNVGVATGIILAHYRTKIKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-06-20" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR24</accession>
    <name>UVRB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein B</fullName>
            <shortName evidence="1">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrB</name>
        <name type="ordered locus">UU120</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAF30526">
        <property type="protein sequence ID" value="AAF30526"/>
        <property type="gene ID" value="UU120"/>
    </dbReference>
    <dbReference type="GeneID" id="29672290"/>
    <dbReference type="KEGG" id="uur:UU120"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_14"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:excinuclease ABC activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="Helicase/UvrB_N"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="UvrB"/>
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        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000138443" description="UvrABC system protein B">
        <location>
            <begin position="1"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="436"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <sequence length="666" mass="76955" checksum="6277F50429283200" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR43</accession>
    <name>Y101_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU101</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
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    <dbReference type="EnsemblBacteria" id="AAF30507">
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        <property type="gene ID" value="UU101"/>
    </dbReference>
    <dbReference type="GeneID" id="29672311"/>
    <dbReference type="KEGG" id="uur:UU101"/>
    <dbReference type="HOGENOM" id="CLU_1447068_0_0_14"/>
    <dbReference type="OMA" id="EENEVCC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220798" description="Uncharacterized protein UU101">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <sequence length="188" mass="21165" checksum="C42591BAFE360A04" modified="2000-10-01" version="1">MAKYIKTGVSYINLDNARTINILPEDIDSYLELGGDEAYKTSDLGSELYINYADFESTNILFDLKKEELQAKIDAFLISNDTVLDLSEVFLDIHFSEDDDYEEDCCCEDECCSDEENEACCNSEVKVEEECCGGAKDDCCGGHEHEHEVCCDSETKTSETQEECCGGTKDDCCGGHEHEHHHHHSHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR45</accession>
    <name>Q9PR45_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I restriction enzyme S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hsdS-3</name>
        <name evidence="6" type="ordered locus">UU099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
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    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="UU099"/>
    </dbReference>
    <dbReference type="GeneID" id="29672243"/>
    <dbReference type="KEGG" id="uur:UU099"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924208_0_0_14"/>
    <dbReference type="OMA" id="VINICKG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="211"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="301" mass="34978" checksum="A258824A8D7EBE6D" modified="2000-10-01" version="1">MNKIEKLINEFCPNGVEFKKLKNIITVAPKSPFGVTKLLKMEKGNYLTITSGKKSFYVDNFLVDGEYIFVNDGGQADIKYNFGKTMYSDHIFAFKVNEYNTKYLYFYLLNISNFINKKLFIGSTLKNLNKKEFLNLAIPIPPISIQNKIVEILDKYTELETELETELETELELRNKQYIYYRNELLNFNKNQTLLKKIMDSDDIKSIDHKIEFKKIEYVCEIKRGQVYSKEFINSNKGNYPVYSSQSLNDGVLGNINKYDFDGEYVTWTTDGAYAGTVFYRKGKFSITNVCGILKVFDNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR47</accession>
    <name>Q9PR47_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction enzyme S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hsdS-2</name>
        <name evidence="5" type="ordered locus">UU097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU097"/>
    <dbReference type="REBASE" id="4888">
        <property type="entry name" value="S.UurORF98BP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30503">
        <property type="protein sequence ID" value="AAF30503"/>
        <property type="gene ID" value="UU097"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU097"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_11_1_14"/>
    <dbReference type="OMA" id="KYVNQAS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="69" mass="8254" checksum="B50AA3FD62B35AC7" modified="2000-10-01" version="1">MSNVMQEIIIPIPPISIQNKIVEILDKLETYTKDINTGLPLEIEQRKKQYEYYRNKLLDFDNIARERES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR55</accession>
    <name>Y08A_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU089.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU089.1</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To Synechocystis PCC 6803 slr1025.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR55"/>
    <dbReference type="STRING" id="273119.UU089.1"/>
    <dbReference type="EnsemblBacteria" id="AAF30495">
        <property type="protein sequence ID" value="AAF30495"/>
        <property type="gene ID" value="UU089.1"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU089.1"/>
    <dbReference type="eggNOG" id="ENOG5033K6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195926_0_0_14"/>
    <dbReference type="OMA" id="YLAMFKN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220797" description="Uncharacterized protein UU089.1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="89" mass="10356" checksum="7A40B383D78A1FF8" modified="2000-10-01" version="1">MYNYKEVKHMGYGKGYLAMFKNKKVRFKVVNSFPDLKVQFVTSFPDYKVKISNSSSFCEETIKIQVVTSFPDVKLQKVTSFGDFEAYID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR56</accession>
    <name>RECR_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">UU089</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688992.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR56"/>
    <dbReference type="SMR" id="Q9PR56"/>
    <dbReference type="STRING" id="273119.UU089"/>
    <dbReference type="EnsemblBacteria" id="AAF30494">
        <property type="protein sequence ID" value="AAF30494"/>
        <property type="gene ID" value="UU089"/>
    </dbReference>
    <dbReference type="GeneID" id="29672204"/>
    <dbReference type="KEGG" id="uur:UU089"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_1_14"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000190419" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="80"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="201" mass="23295" checksum="2A5060F39EA99C8B" modified="2000-10-01" version="1">MSKPVEFEMLVDALKSLPGVGTKNANKWAFFLLQQDQKYIDDLIKRIKEAKTNILKCKYCANFTNKDECDICLNEYRDFTKLMIVTTNEDLERIESANIYNGLYHITNGEISLRKNVVIEHTNIKTIKERVLNGSFKEIIIATSYTHDGEVTADYIIRMLEDIKDLQIYRIGFGIPLNSSIDYADDETLKQSLINKRKIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR58</accession>
    <name>Q9PR58_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">dnaX</name>
        <name evidence="4" type="ordered locus">UU087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688985.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU087"/>
    <dbReference type="EnsemblBacteria" id="AAF30492">
        <property type="protein sequence ID" value="AAF30492"/>
        <property type="gene ID" value="UU087"/>
    </dbReference>
    <dbReference type="GeneID" id="29672171"/>
    <dbReference type="KEGG" id="uur:UU087"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.90"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_0_3_14"/>
    <dbReference type="OMA" id="PAYLFNG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="597" mass="69039" checksum="C61CC497BF113D1E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR60</accession>
    <name>RNY_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Y</fullName>
            <shortName evidence="1">RNase Y</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rny</name>
        <name type="ordered locus">UU085</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688749.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR60"/>
    <dbReference type="SMR" id="Q9PR60"/>
    <dbReference type="STRING" id="273119.UU085"/>
    <dbReference type="EnsemblBacteria" id="AAF30490">
        <property type="protein sequence ID" value="AAF30490"/>
        <property type="gene ID" value="UU085"/>
    </dbReference>
    <dbReference type="GeneID" id="29672747"/>
    <dbReference type="KEGG" id="uur:UU085"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_14"/>
    <dbReference type="OMA" id="PHAILGM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000163806" description="Ribonuclease Y">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="285"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="473" mass="54323" checksum="D02D83602817F112" modified="2000-10-01" version="1">MGYLIAFIILLILFVLLITIVPVVMVVYLKKKQLKLTFVPKSQTSFKKIVQKTKDLEEECEDLNNKNNELKKAISDQNLQIDLLKKNNENFLLNATSLTAEQAKKELFNLLKIKFKKELAQEYAKIKHEFNEAQEIYAQNILVETMEQIAEPLIVERSLFNIDIIDENLKGKIIGRDGRNKAVFENEGGVDLIVDRQQPIVGISTPNPIRREIARIVMQKLIDSKNIDINRIELLFKEEREKFEKKVFEIGKNVVEQTLGFFDLPEGIYSYIGRMKFRNSYGQNILSHSLEVAEYAERIAKLINIDPIKAKKAAFFHDIGKTIDFESDLDHVEAGLLIAKKFNLDDYIYNAIESHHNKVIPTTIYGALVKIVDTLSAARPGARVNSYDEYYSRVKELETICMRFEGVKSAYVIKSGRQLRVIVDSNLVSDEQLELLGHEIKVAIEENDLLTNYKIKIVLIKEKRISIDTNIIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR61</accession>
    <name>RECA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recA</name>
        <name type="ordered locus">UU084</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688656.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR61"/>
    <dbReference type="SMR" id="Q9PR61"/>
    <dbReference type="STRING" id="273119.UU084"/>
    <dbReference type="EnsemblBacteria" id="AAF30489">
        <property type="protein sequence ID" value="AAF30489"/>
        <property type="gene ID" value="UU084"/>
    </dbReference>
    <dbReference type="GeneID" id="29672269"/>
    <dbReference type="KEGG" id="uur:UU084"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_1_2_14"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000122889" description="Protein RecA">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <sequence length="334" mass="37285" checksum="14015851BE700CA4" modified="2000-10-01" version="1">MKENNNLEKLDPIATLETKFAKSSYFIADEIKDEKINAISTGSIHIDQITGINGIPVGKITEIYGNESSGKTTIALQTIAECQKTGGTVVLLDLEGSFDINYAKSLKVDLTKLIITQPQTGEQAFDMIETLIKTNSIDLIVIDSVAAMLPESEYQANMNEALMGAHARLMSKGLRKIQPLINKSKTAIIFINQLREKINTFFGNPEMTTGGKALKFYASLRIETKKADLIKEGINKIGIKTKVTTVKNKLAPPLQTCFIDIFFGSGFDYNNEIIDFAIQYGVLKKNGSWFYFNDNKIGQGREQLKNTLSKNNELFIQISEKTLEFVNNEKSNWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR64</accession>
    <name>Q9PR64_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gyrB</name>
        <name evidence="13" type="ordered locus">UU081</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688798.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU081"/>
    <dbReference type="EnsemblBacteria" id="AAF30486">
        <property type="protein sequence ID" value="AAF30486"/>
        <property type="gene ID" value="UU081"/>
    </dbReference>
    <dbReference type="GeneID" id="29672190"/>
    <dbReference type="KEGG" id="uur:UU081"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.83"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_14"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="435"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAF30486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="650" mass="73730" checksum="C4F975A652182E17" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-08-29" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR69</accession>
    <name>HPRK_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>HPr kinase/phosphorylase</fullName>
            <shortName>HPrK/P</shortName>
            <ecNumber>2.7.11.-</ecNumber>
            <ecNumber>2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hprK</name>
        <name type="ordered locus">UU076</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-"/>
    <dbReference type="EC" id="2.7.4.-"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688665.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR69"/>
    <dbReference type="SMR" id="Q9PR69"/>
    <dbReference type="STRING" id="273119.UU076"/>
    <dbReference type="EnsemblBacteria" id="AAF30481">
        <property type="protein sequence ID" value="AAF30481"/>
        <property type="gene ID" value="UU076"/>
    </dbReference>
    <dbReference type="GeneID" id="29672184"/>
    <dbReference type="KEGG" id="uur:UU076"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052030_0_1_14"/>
    <dbReference type="OMA" id="AMNNRQK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000059005" description="HPr kinase/phosphorylase">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="1">
        <location>
            <begin position="268"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="308" mass="35014" checksum="313991B738C9D395" modified="2000-10-01" version="1">MEIRGKLFVSQVVRKFNLNVVANSDYIDREISTTGITRVGFELAGEILFKEIWNIVYFGSKESNYFNKFSETIISKKLGKILDLNPPLIIFGKNFKHAGILLKLAERYKIPIVEVKYSFYELNFTINSYISQKLSHQSLVHGTLLSVFGIGVILMGESGVGKSELAIELVKKGHIFVGDDAILVNRIGGNLYGRAEDSTKDFIEIRGLGIMNFSRSFGIERMIESTKIEIVIELIKPAKHEKIKFERFGREIQHKEFLETKIAHYYIPVIEGRSISDIIETAITDYKLKTSGYNSAEEFILQINKKGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR83</accession>
    <name>SYK_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Lysine--tRNA ligase</fullName>
            <ecNumber>6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Lysyl-tRNA synthetase</fullName>
            <shortName>LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lysS</name>
        <name type="ordered locus">UU062</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688759.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR83"/>
    <dbReference type="SMR" id="Q9PR83"/>
    <dbReference type="STRING" id="273119.UU062"/>
    <dbReference type="EnsemblBacteria" id="AAF30467">
        <property type="protein sequence ID" value="AAF30467"/>
        <property type="gene ID" value="UU062"/>
    </dbReference>
    <dbReference type="GeneID" id="29672283"/>
    <dbReference type="KEGG" id="uur:UU062"/>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_14"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152699" description="Lysine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="493" mass="57303" checksum="3F18607C5E976E2A" modified="2000-10-01" version="1">MERKFSDQELIRRTHLQELKNQNKNPFLITKVDRSMFLKDFAEKYKNFSKEELHNMDLEKLTLAGRLIGIRQTFGIIQDFSAKLQIYINKKNVAPEVFSTFKSLDIGDIIELEGVAMKTNSDEITLNVTNIRLVAKSLKVLPEKYHGLVDEEIKARQRYLDLIVNDETKNTFIKRSLIIREMRNWLDNKGFFEVETPVLQDILSGAAARPFITHHNTLNKEYYLRIATEIALKKCIIGGFEKVYEIGRIFRNEGMDSTHNPEFTSVELYIAYVDLWYIMQLTEDLIRHIATKLNLLNPTFRGFSIDLNKPFKKAHMVDLINEYVGVNFFEVKSDEQAIELAKKHHVKLLDHQKNFGHIVNAFFETFVEEKLVEPTFVYGHPLQVSPLTKKNQSDPRFVDRFELFICQKEFANAYSEINDPIDQYERFIAQLEEAKLGNDEASELDMEFIEALEYGMPPTGGLGIGVDRLVMLLTSNDSIRNVLLFPHMKDKTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR84</accession>
    <name>Y061_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU061</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU061</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689028.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR84"/>
    <dbReference type="SMR" id="Q9PR84"/>
    <dbReference type="STRING" id="273119.UU061"/>
    <dbReference type="EnsemblBacteria" id="AAF30466">
        <property type="protein sequence ID" value="AAF30466"/>
        <property type="gene ID" value="UU061"/>
    </dbReference>
    <dbReference type="GeneID" id="29672252"/>
    <dbReference type="KEGG" id="uur:UU061"/>
    <dbReference type="eggNOG" id="ENOG50338H3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053542_0_0_14"/>
    <dbReference type="OMA" id="NEYTHRS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220794" description="Uncharacterized protein UU061">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="264" mass="32205" checksum="0EDA95C31FBC09BF" modified="2000-10-01" version="1">MTSLDITTLVISILSLIATLSISFNIYFIELRKQRERKIERLQQEAKQFIINNLDEKDFIVLCQFIYKLYKHDKHTRKIHYEFVLLNEPVQKEVFKQLEILNIVDFKDNEWIANKFSILKEIVNDYQLGNWDDYKFYENFNFAYTLFREEKCDAVFEEIKQNKFGGKNLSFHEYLNEYAHRSKESDMLAPIDYFIDQNNLNNVFDRQKHAIYKLYLLDLILNELCRSMNNDHRINNEFKYFDCEVIYVEDLYLKILYKLYFQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR85</accession>
    <name>Q9PR85_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">msbA-2</name>
        <name evidence="11" type="ordered locus">UU060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689063.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU060"/>
    <dbReference type="EnsemblBacteria" id="AAF30465">
        <property type="protein sequence ID" value="AAF30465"/>
        <property type="gene ID" value="UU060"/>
    </dbReference>
    <dbReference type="GeneID" id="29672307"/>
    <dbReference type="KEGG" id="uur:UU060"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.62"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_14"/>
    <dbReference type="OMA" id="LGIMLWG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="29"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="361"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAF30465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="598" mass="68188" checksum="677038D767F96B5D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR87</accession>
    <name>SSRP_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smpB</name>
        <name type="ordered locus">UU058</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688578.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR87"/>
    <dbReference type="SMR" id="Q9PR87"/>
    <dbReference type="STRING" id="273119.UU058"/>
    <dbReference type="EnsemblBacteria" id="AAF30463">
        <property type="protein sequence ID" value="AAF30463"/>
        <property type="gene ID" value="UU058"/>
    </dbReference>
    <dbReference type="GeneID" id="29672291"/>
    <dbReference type="KEGG" id="uur:UU058"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_1_14"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000103062" description="SsrA-binding protein">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <sequence length="141" mass="16700" checksum="C4A9AC71EA7EB712" modified="2000-10-01" version="1">MIVSNKHARRNYELLDFFECGIVLKGTEVKSISRANCSINEAYVQIIKNQALILNMHVANFFEGNNFNQDPYRNRKLLLHKKEIIRLQHLVKTQHMTIVPTKIYWKNNKLKIEIALGKGKQLHDKREDIKKRDLARETRLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA1</accession>
    <name>Y044_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU044</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU044</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">To U.parvum UU046.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688509.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRA1"/>
    <dbReference type="SMR" id="Q9PRA1"/>
    <dbReference type="STRING" id="273119.UU044"/>
    <dbReference type="EnsemblBacteria" id="AAF30449">
        <property type="protein sequence ID" value="AAF30449"/>
        <property type="gene ID" value="UU044"/>
    </dbReference>
    <dbReference type="GeneID" id="29672318"/>
    <dbReference type="KEGG" id="uur:UU044"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020577_0_0_14"/>
    <dbReference type="OMA" id="YKRINDG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030942">
        <property type="entry name" value="Mycoplas_M_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030941">
        <property type="entry name" value="Predic_Ig_block"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04524">
        <property type="entry name" value="mycoplas_M_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04526">
        <property type="entry name" value="predic_Ig_block"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220788" description="Uncharacterized protein UU044">
        <location>
            <begin position="1"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="782" mass="88546" checksum="9200C82C0FAFF11D" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB0</accession>
    <name>Y035_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU035</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU035</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891658.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRB0"/>
    <dbReference type="STRING" id="273119.UU035"/>
    <dbReference type="PRIDE" id="Q9PRB0"/>
    <dbReference type="EnsemblBacteria" id="AAF30440">
        <property type="protein sequence ID" value="AAF30440"/>
        <property type="gene ID" value="UU035"/>
    </dbReference>
    <dbReference type="GeneID" id="29672240"/>
    <dbReference type="KEGG" id="uur:UU035"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.37"/>
    <dbReference type="eggNOG" id="ENOG5030SHB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178959_0_0_14"/>
    <dbReference type="OMA" id="ECIDGRY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220785" description="Uncharacterized protein UU035">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <sequence length="252" mass="29532" checksum="89A1842C59CD3660" modified="2000-10-01" version="1">MRKFNKMLSNKKFLDLDIIKESFDNYLSVGTSRSTKKLKTLHGSIAKDLEELLGKEYNIKSQGYRDDKEECIDGRYYNKKVDITIKNNGKSIAGLAIKFVMSNYSQNSNNYFENMLGETANLRSNSVPYFQIFIIFDKVPYYKSDGVLQKYDNISNHNLEKYLKLSDDDPKVYFHTPDKTLFILLSLKEISEEIKNKKDYIRCYKEIMNDEDLLSYSNKIDDLFGNSIILNNYEDFIKRMCALIIGYQKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB2</accession>
    <name>Q9PRB2_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4065 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891656.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU033"/>
    <dbReference type="EnsemblBacteria" id="AAF30438">
        <property type="protein sequence ID" value="AAF30438"/>
        <property type="gene ID" value="UU033"/>
    </dbReference>
    <dbReference type="GeneID" id="29672257"/>
    <dbReference type="KEGG" id="uur:UU033"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.35"/>
    <dbReference type="eggNOG" id="COG3600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110683_0_1_14"/>
    <dbReference type="OMA" id="KEDGAWH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025272">
        <property type="entry name" value="SocA_Panacea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13274">
        <property type="entry name" value="DUF4065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4065" evidence="1">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="157" mass="18786" checksum="7C609004B111471A" modified="2000-10-01" version="1">MKEITPLIVANWFLTKESMTPKKVQKLVYYAYSWYLTLMNEKVDDLKNKLFDEKIKAWVHEPAIPMLYNEFKEHKYNSIPKINDFNELEYFNLDTIDILNQVWDEYGHYSANQLESITHQEDPWIKARKGFGPLDSCNAVISDKEIFSYYIKQMKNN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC5</accession>
    <name>KTHY_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Thymidylate kinase</fullName>
            <ecNumber>2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tmk</name>
        <name type="ordered locus">UU020</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAF30425" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.4.9"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30425.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H82944">
        <property type="entry name" value="H82944"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688582.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRC5"/>
    <dbReference type="SMR" id="Q9PRC5"/>
    <dbReference type="STRING" id="273119.UU020"/>
    <dbReference type="EnsemblBacteria" id="AAF30425">
        <property type="protein sequence ID" value="AAF30425"/>
        <property type="gene ID" value="UU020"/>
    </dbReference>
    <dbReference type="GeneID" id="29672189"/>
    <dbReference type="KEGG" id="uur:UU020"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_14"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155366" description="Thymidylate kinase">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="230" mass="26900" checksum="FE93B27E19635B3D" modified="2001-06-01" version="2">MILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNLEVFDPLTLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNNALNRMKNRFDNTNAFDSQNKQFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRC6</accession>
    <name>Q9PRC6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaH</name>
        <name evidence="1" type="ordered locus">UU019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688710.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU019"/>
    <dbReference type="EnsemblBacteria" id="AAF30424">
        <property type="protein sequence ID" value="AAF30424"/>
        <property type="gene ID" value="UU019"/>
    </dbReference>
    <dbReference type="GeneID" id="29672246"/>
    <dbReference type="KEGG" id="uur:UU019"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.19"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_5_14"/>
    <dbReference type="OMA" id="ENNPDYH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="264" mass="30985" checksum="3EDA2C59CD577728" modified="2000-10-01" version="1">MKYSFANLLIQSPKTSLESGIEEIMLAFIYEKNHKEQSFYVTKVKNKQYFDLKIYDGLSMKKSDVIDLQNTFLCDGVEDINLKFYLIKNIDLASKYVLNALLKFIEEPPKNTIAIFSTKNLNQVLKTIKSRCQLFYLPTNHDLYKKLINQINQPIDLVECDLMFDDLDELKILLENKEINDVLTYYGKLSDLRSFEILNDLKEIFKNLSTLQIHYLLKLIFIRINNVNSKEIILDLMRANLKININKNNLFTIIYTIINKNKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD6</accession>
    <name>Q9PRD6_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ordered locus">UU009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688603.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU009"/>
    <dbReference type="EnsemblBacteria" id="AAF30414">
        <property type="protein sequence ID" value="AAF30414"/>
        <property type="gene ID" value="UU009"/>
    </dbReference>
    <dbReference type="GeneID" id="29672327"/>
    <dbReference type="KEGG" id="uur:UU009"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.9"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_14"/>
    <dbReference type="OMA" id="TMTVAVR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAF30414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="540" mass="60811" checksum="105AE6CBB57CB182" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD7</accession>
    <name>Y008_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU008</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU008</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">To U.parvum UU007, UU041 and UU042.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688510.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRD7"/>
    <dbReference type="SMR" id="Q9PRD7"/>
    <dbReference type="STRING" id="273119.UU008"/>
    <dbReference type="EnsemblBacteria" id="AAF30413">
        <property type="protein sequence ID" value="AAF30413"/>
        <property type="gene ID" value="UU008"/>
    </dbReference>
    <dbReference type="GeneID" id="29672239"/>
    <dbReference type="KEGG" id="uur:UU008"/>
    <dbReference type="HOGENOM" id="CLU_1668658_0_0_14"/>
    <dbReference type="OMA" id="PDYQDAY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220781" description="Uncharacterized protein UU008">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="158" mass="16990" checksum="ACF974AA54936969" modified="2000-10-01" version="1">MNFTSLLQDGIYEVGNGAIVTDQSPYLGITPDYQGAYGFPTHPWGIFFQVVGAILVFGAYLPAVIKVLISKRTENLAIGMWIISIAGLGLLAIFAWLGVSVNPGGFILVALSETLSCIASIIVFALKIANKAKAKAAGMTELEYCNLHYPIVKKLPKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>P0C7K8</accession>
    <accession>Q56558</accession>
    <name>URE2_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ureB</name>
        <name type="ordered locus">UU433</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="647" last="655">
            <title>Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli.</title>
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8550495"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="2725" last="2725">
            <authorList>
                <person name="Neyrolles O."/>
                <person name="Ferris S."/>
                <person name="Behbahani N."/>
                <person name="Montagnier L."/>
                <person name="Blanchard A."/>
            </authorList>
            <dbReference type="PubMed" id="8626347"/>
        </citation>
        <scope>ERRATUM OF PUBMED:8550495</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="Int. J. Syst. Bacteriol." volume="49" first="1879" last="1889">
            <title>Phylogenetic analysis of Ureaplasma urealyticum -- support for the establishment of a new species, Ureaplasma parvum.</title>
            <authorList>
                <person name="kong F."/>
                <person name="James G."/>
                <person name="Ma Z."/>
                <person name="Gordon S."/>
                <person name="Bin W."/>
                <person name="Gilbert G.L."/>
            </authorList>
            <dbReference type="PubMed" id="10555372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 27813 / 7 / Serovar 1</strain>
            <strain>ATCC 27818 / Pi / Serovar 6</strain>
            <strain>ATCC 33697 / U26 / Serovar 14</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="L40489">
        <property type="protein sequence ID" value="AAA89188.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085730">
        <property type="protein sequence ID" value="AAD28135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085731">
        <property type="protein sequence ID" value="AAD28138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF085733">
        <property type="protein sequence ID" value="AAD28144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H82890">
        <property type="entry name" value="H82890"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688518.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P0C7K8"/>
    <dbReference type="SMR" id="P0C7K8"/>
    <dbReference type="STRING" id="273119.UU433"/>
    <dbReference type="EnsemblBacteria" id="AAF30845">
        <property type="protein sequence ID" value="AAF30845"/>
        <property type="gene ID" value="UU433"/>
    </dbReference>
    <dbReference type="GeneID" id="29672369"/>
    <dbReference type="KEGG" id="uur:UU433"/>
    <dbReference type="eggNOG" id="COG0832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129707_1_1_14"/>
    <dbReference type="OMA" id="FYEVNDA"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000067583" description="Urease subunit beta">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <sequence length="124" mass="13509" checksum="743DDE240805F1F5" modified="2008-05-20" version="1">MSGSSSQFSPGKLVPGAINFASGEIVMNEGREAKVISIKNTGDRPIQVGSHFHLFEVNSALVFFDEKGNEDKERKVAYGRRFDIPSGTAIRFEPGDKKEVSIIDLAGTREVWGVNGLVNGKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPP8</accession>
    <name>Q9PPP8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU591"/>
    <dbReference type="EnsemblBacteria" id="AAF31005">
        <property type="protein sequence ID" value="AAF31005"/>
        <property type="gene ID" value="UU591"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU591"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175031_0_0_14"/>
    <dbReference type="OMA" id="NYLTHYF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF31005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="239" mass="28406" checksum="3C55B8B4E245A07B" modified="2000-10-01" version="1">MIPLNYLTHYFSLKYKGDWSKIYLALINHEDQNEYLFLEKEDYEKVKAIDLTDEKYPNKYKKINQPPFILYYSTTVEWLDKKNIWLIDYENAISNYDILTLIKAGYGFVIYYDSVVLDTLINRLISLKARICIITDEGIYSSKNIKYLSYCNVSVISEIPKDYNSNKITQDLKRLACASSDHILCVNELYQIDDYLFNKYKDCQLDLVLLDKKLAKQNTIYPKYINRIYQFIKNSKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPQ3</accession>
    <name>Q9PPQ3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tktA</name>
        <name evidence="11" type="ordered locus">UU586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF31000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688522.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU586"/>
    <dbReference type="EnsemblBacteria" id="AAF31000">
        <property type="protein sequence ID" value="AAF31000"/>
        <property type="gene ID" value="UU586"/>
    </dbReference>
    <dbReference type="GeneID" id="29672655"/>
    <dbReference type="KEGG" id="uur:UU586"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.609"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_14"/>
    <dbReference type="OMA" id="YALQQTD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="10">
        <location>
            <begin position="345"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAF31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="653" mass="73534" checksum="513BC90A06B6B413" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR0</accession>
    <name>Q9PPR0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">UU579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688438.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU579"/>
    <dbReference type="EnsemblBacteria" id="AAF30993">
        <property type="protein sequence ID" value="AAF30993"/>
        <property type="gene ID" value="UU579"/>
    </dbReference>
    <dbReference type="GeneID" id="29672205"/>
    <dbReference type="KEGG" id="uur:UU579"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.602"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035815_0_0_14"/>
    <dbReference type="OMA" id="FNYSFYY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="537" mass="61229" checksum="221D9B7F44A85988" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPR4</accession>
    <name>Q9PPR4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688790.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU575"/>
    <dbReference type="EnsemblBacteria" id="AAF30989">
        <property type="protein sequence ID" value="AAF30989"/>
        <property type="gene ID" value="UU575"/>
    </dbReference>
    <dbReference type="GeneID" id="29672153"/>
    <dbReference type="KEGG" id="uur:UU575"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.598"/>
    <dbReference type="eggNOG" id="COG4866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876997_0_0_14"/>
    <dbReference type="OMA" id="GFINNDK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="317" mass="37858" checksum="296DD9BBF751B335" modified="2000-10-01" version="1">MYTKLTWNNYEFVEQIKEDINPGQQISTLTLLLWTYYGYDIYFEYLKDKNIVLFYAQANEELKIIEQNKIATQFIGKFFIIFAYFDAKKYDWTTLIPIALEALKTNFKKEFLLAINGIQDENYLNNLSQFNFELIYSWYSNFIYETQSLKYFCGKILQKKRNNLNFFIKNFKNDYEIIKYNPKFHLHEVCTFLKEWDVKNFINSKRMLVNSNSDLLLNTQTNPYFMGSLLIKKSINKIVGFTLVYTRPNIAEILIEQTDREIRGMYQYLLSQNLIINNINNWLIDRQDGAWSDNISASKLSYAPKIITKRVNVLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS0</accession>
    <name>Q9PPS0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688535.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU569"/>
    <dbReference type="EnsemblBacteria" id="AAF30983">
        <property type="protein sequence ID" value="AAF30983"/>
        <property type="gene ID" value="UU569"/>
    </dbReference>
    <dbReference type="GeneID" id="29672719"/>
    <dbReference type="KEGG" id="uur:UU569"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.592"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_3_1_14"/>
    <dbReference type="OMA" id="WTAWLDI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="277" mass="32006" checksum="BC38742D194D0041" modified="2000-10-01" version="1">MQYKMLVIDLDGTLLTKTKNISKANLQGLKKYISLGGKVVLSTGRSLENTLKIVHLIHDQIKELIQYISCFNGSYIYDVINEKVLFESTINKDIVNEIYKFSLKHGLGFWPYNQRFMQTHFLDVYNINYKFLLQLHHTKRKVCLNPIFNKNDKFYKINILPSNFVKKLKHEVIDQLIKEFSDQVNISFTSKYIVEVTNKNINKASSLRFIANLYQINLDKVATIGDSPNDIPMFKISGLAAAARTKSKTIIEHVDVIINYKNNSNSVALFINNYLLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS1</accession>
    <name>RS16_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name evidence="1" type="synonym">rps16</name>
        <name type="ordered locus">UU568</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPS1"/>
    <dbReference type="SMR" id="Q9PPS1"/>
    <dbReference type="STRING" id="273119.UU568"/>
    <dbReference type="EnsemblBacteria" id="AAF30982">
        <property type="protein sequence ID" value="AAF30982"/>
        <property type="gene ID" value="UU568"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU568"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_2_14"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000167277" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <sequence length="101" mass="11297" checksum="FED91E1AB36CBF45" modified="2000-10-01" version="1">MKILVKIRLTRVGTHKKPFFRIVVMDAKTKANGAYIENLGHYDPVLGQVVLKKEAILAQLQNGAQPSETVKNILSQEGIWKEFIALKDANKKRKAALSKAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPS3</accession>
    <name>RL19_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplS</name>
        <name evidence="1" type="synonym">rpl19</name>
        <name type="ordered locus">UU566</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688591.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPS3"/>
    <dbReference type="SMR" id="Q9PPS3"/>
    <dbReference type="STRING" id="273119.UU566"/>
    <dbReference type="EnsemblBacteria" id="AAF30980">
        <property type="protein sequence ID" value="AAF30980"/>
        <property type="gene ID" value="UU566"/>
    </dbReference>
    <dbReference type="GeneID" id="29672701"/>
    <dbReference type="KEGG" id="uur:UU566"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_2_14"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000163564" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <sequence length="123" mass="13983" checksum="FFBBD38837B7AA15" modified="2000-10-01" version="1">MALFKINKGEIMNFVNSTQLKTDIPNFDSGDTIIVHNRIVEGKKSRIQKFEGVVLRRRGSGSSETVIVRKESSGIGVEQSFNIHSPLVEKIEVIKYGKVRRAYISYMRNRSGKSARIKELNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT0</accession>
    <name>Q9PPT0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oppD</name>
        <name evidence="6" type="ordered locus">UU560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689057.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU560"/>
    <dbReference type="EnsemblBacteria" id="AAF30973">
        <property type="protein sequence ID" value="AAF30973"/>
        <property type="gene ID" value="UU560"/>
    </dbReference>
    <dbReference type="GeneID" id="29672619"/>
    <dbReference type="KEGG" id="uur:UU560"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.582"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_14"/>
    <dbReference type="OMA" id="MTKINNP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="162"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="506" mass="57963" checksum="7B44985A0C3B6B4A" modified="2000-10-01" version="1">MKQKNNRYTYINYLRSQRAFIQTLKPQILKLTSNNVCLNEQEVDLEPQLNNLEDINIQLTNEKVNIQDIVTLEEEINVKDNNQNQNLNEEILATTLINEQASGINEISEQKETTIANKKHKKQTMAFKAANSRKNFDFEKFEKNVKYKSFKDGTVKKIAAEIENVRLTFTNPSKPNDRALVLRNTSVQFYEGEVHAIIGESGSGKSVITSLLYGLAGKNANVEEGKILLYNNEVQDFSFKDWEKSRYLGKVISAVFQNPMSTLNPTMKIGKQIMEGMLINGIVKTRKEAYNKSIEYLKLTKINNPEEIMELYPHELSGGMIQRVVIASIVSLHPKILVLDEPTTALDPTVQALVLDVIRELQEKFKMCIIFITHDLGVVASIANYISIMYAGQIIEEGQRDEILWYPQHPYTWGLIMSMPDVNKGDRLATIKGSVPSRLNDIVGDAFAIRNDYALTRDFEHEPEMYHVSETHRVKSALLDERAEKYTPPQIILDKWNNFKKRQENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT3</accession>
    <name>Q9PPT3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688653.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU557"/>
    <dbReference type="EnsemblBacteria" id="AAF30970">
        <property type="protein sequence ID" value="AAF30970"/>
        <property type="gene ID" value="UU557"/>
    </dbReference>
    <dbReference type="GeneID" id="29672588"/>
    <dbReference type="KEGG" id="uur:UU557"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.579"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011114_0_0_14"/>
    <dbReference type="OMA" id="YYSADKT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016880">
        <property type="entry name" value="ABC_oligopep_solut-bd_myco_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028335">
        <property type="entry name" value="ABC_oligopep_OppA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="390"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1131" mass="130079" checksum="C45DBBF61E18690B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPT4</accession>
    <name>Q9PPT4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688639.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU556"/>
    <dbReference type="EnsemblBacteria" id="AAF30969">
        <property type="protein sequence ID" value="AAF30969"/>
        <property type="gene ID" value="UU556"/>
    </dbReference>
    <dbReference type="GeneID" id="29672580"/>
    <dbReference type="KEGG" id="uur:UU556"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.578"/>
    <dbReference type="HOGENOM" id="CLU_1634664_0_0_14"/>
    <dbReference type="OMA" id="HYASAIF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="162" mass="19140" checksum="D1DAF4AA183AC623" modified="2000-10-01" version="1">MDLIFKRLKFISIQNWVLLLFAAALFVCVGAWIGHELVRHNLFDAYTLNHEKELINMLNPKDLEVYLSQKEQIRLSIGFFGLFLVLWTLTYLISLVVNIRILIKYLNDFNENKTKVKKALIISLIPFIHYVSSILLTVVYDKVFNWNRKKSHTLQEEYISAY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-07-25" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV0</accession>
    <name>RL1_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name evidence="1" type="synonym">rpl1</name>
        <name type="ordered locus">UU540</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688527.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPV0"/>
    <dbReference type="SMR" id="Q9PPV0"/>
    <dbReference type="STRING" id="273119.UU540"/>
    <dbReference type="EnsemblBacteria" id="AAF30953">
        <property type="protein sequence ID" value="AAF30953"/>
        <property type="gene ID" value="UU540"/>
    </dbReference>
    <dbReference type="GeneID" id="29672436"/>
    <dbReference type="KEGG" id="uur:UU540"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_14"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125771" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="229" mass="25167" checksum="72F7F41DC9068E29" modified="2000-10-01" version="1">MAKISKKLFAAYEGIDKQKAYPLFDAIKLAQEKSITKFDGSINIAIKLNLDTTKVEQQLRGSISLPNGNGKNVRVLVLSEDITKEEAASVGADYFGGADYIQNIEKMLNQIDVIITNQKMMPLLAKLGKVLGPRGLMPNPKIGTVTNDVLKAVEEFKRGRIEYRTDTYGNIHMSIGRVSFETTKIEENANALLNLIKSKKPATVKGQYIQNIAVSPTMGPGIKVVINNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPV8</accession>
    <name>Q9PPV8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">XAA-PRO aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepP</name>
        <name evidence="6" type="ordered locus">UU532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688572.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU532"/>
    <dbReference type="EnsemblBacteria" id="AAF30945">
        <property type="protein sequence ID" value="AAF30945"/>
        <property type="gene ID" value="UU532"/>
    </dbReference>
    <dbReference type="GeneID" id="29672396"/>
    <dbReference type="KEGG" id="uur:UU532"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.552"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_0_14"/>
    <dbReference type="OMA" id="YCSDRTR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="5">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="143"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="357" mass="39414" checksum="EED7D034C791C2C7" modified="2000-10-01" version="1">MSDFKLQQVLKTIKEHEAQGADGMILFSNYNRYWFLEFASSDGFVFINKDGKAIYLVDARYYTAASETVKNAKVILLARTPQKSTFDLLKDAMVELNITNALVEADYVTLDVHEMLKKLVKNTTPFTSATLRAIKTEKELEYLQKAADIAALTCNWIREQDIIGRTELEIATLVSKHMLELGGELNSFDPIIASGPNGGSPHHHPGNRVIEDGDMVTVDIGCTYKGYCSDITRSFIVGNKANPQMQEIYDKVLESQTAGINLLSTKVTGQEVDKVCRDIVDNSKFKGYFTHGTGHGVGLQVHELPNTNAGNPNKLPLNAVVTVEPGIYIPNVGGVRIEDTIVVKDGQALVLTRLAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW0</accession>
    <name>Q9PPW0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cpsG</name>
        <name evidence="6" type="ordered locus">UU530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891810.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU530"/>
    <dbReference type="EnsemblBacteria" id="AAF30943">
        <property type="protein sequence ID" value="AAF30943"/>
        <property type="gene ID" value="UU530"/>
    </dbReference>
    <dbReference type="GeneID" id="29672386"/>
    <dbReference type="KEGG" id="uur:UU530"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.550"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_0_14"/>
    <dbReference type="OMA" id="PQDNGYK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="44"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="206"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="318"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="552" mass="64309" checksum="F3FB5E15EFC98DE0" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW2</accession>
    <name>Q9PPW2_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dcm</name>
        <name evidence="8" type="ordered locus">UU528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU528"/>
    <dbReference type="REBASE" id="4895">
        <property type="entry name" value="M.UurORF528P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30941">
        <property type="protein sequence ID" value="AAF30941"/>
        <property type="gene ID" value="UU528"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU528"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.548"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_0_6_14"/>
    <dbReference type="OMA" id="IGAQHKA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="299" mass="34487" checksum="FA1EDA2D8CC794A3" modified="2000-10-01" version="1">MTGEQLIKSVGNKGIDLLTYSFPCQDLSTAGSFSKKAFGMKKGSGTRSGLLWEIERILFDLQKLNQLPQFLLLENVNNMLSKQHKLDYDMWTKSLKQLGYSTCTFQLNALDYGSAQRRKRVYAISILNYDGLIDSNGNILDLEAPIFDGKQKQLKDVLKTNYKIEKYYQEAYLAQPNRTFSRIKYVIPKYDLLNPNCYCTSTITTRQDRFPNGGYINLKNTILGDDYREKDHNNLPKKANFRLLTNREAYLLMGFNEKDFEAIQAKGISKAKMYQQAGNSIVVDVMVYLMKLIQERFNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-20" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPW5</accession>
    <name>RS12_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsL</name>
        <name evidence="2" type="synonym">rps12</name>
        <name type="ordered locus">UU525</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026220.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPW5"/>
    <dbReference type="SMR" id="Q9PPW5"/>
    <dbReference type="STRING" id="273119.UU525"/>
    <dbReference type="EnsemblBacteria" id="AAF30938">
        <property type="protein sequence ID" value="AAF30938"/>
        <property type="gene ID" value="UU525"/>
    </dbReference>
    <dbReference type="GeneID" id="45016147"/>
    <dbReference type="KEGG" id="uur:UU525"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_14"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000146349" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-methylthioaspartic acid" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="141" mass="15627" checksum="A5AEC5EAEAC3645C" modified="2000-10-01" version="1">MPTIAQLIRNKRAPKVKKTKSPALLFTYNSLHKKTTKNPSPLKSGVCTRVGTMTPKKPNSALRKYAKVRLSNGFEVLAYIPGEGHNLQEHSVVVIRGGRVKDLPGVRYHIVRGAGDASGVEKRRQQRSLYGAKRPKKEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX3</accession>
    <name>Q9PPX3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferric anguibactin transport system permerase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fatC-3</name>
        <name evidence="8" type="ordered locus">UU516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688668.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU516"/>
    <dbReference type="EnsemblBacteria" id="AAF30929">
        <property type="protein sequence ID" value="AAF30929"/>
        <property type="gene ID" value="UU516"/>
    </dbReference>
    <dbReference type="GeneID" id="29672232"/>
    <dbReference type="KEGG" id="uur:UU516"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.536"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064507_0_0_14"/>
    <dbReference type="OMA" id="FIIMIRR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="341" mass="38194" checksum="EE4E845A7705A01C" modified="2000-10-01" version="1">MINLNTWNKTHSFKNPLKYQNKIAYLKTMITVIISIVVFIITLAWTYDFNFKQDNIALAYIIMQIFLSGFILGFCAYLIQKLTKNRFSDTSIMGISSVNILGVIIIAFQVDFNNFSADKLSTLEHTEPIIFFIAPIILCMLYYFTCKEQSSFNYKKMLISGVIVNFLSVALGASIAKNLPKLANAYVSRYTYGSIEPQQESFFIALVLIIIGLLIVLFNFKKIQIVSSNQDLANQLGINVKLTSGLLLVAICLMVGASYSLNGNLIFIGLMAGNMGSVISNNRFKSAAISSGCCGSLIYMLSFLLFIKILNFDSQWLNLAIPLIISPYFIYIIVKKNKSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX4</accession>
    <name>Q9PPX4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical ferrichrome ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ABC-3</name>
        <name evidence="8" type="ordered locus">UU515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689097.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU515"/>
    <dbReference type="EnsemblBacteria" id="AAF30928">
        <property type="protein sequence ID" value="AAF30928"/>
        <property type="gene ID" value="UU515"/>
    </dbReference>
    <dbReference type="GeneID" id="29672231"/>
    <dbReference type="KEGG" id="uur:UU515"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.535"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067576_0_0_14"/>
    <dbReference type="OMA" id="GAPCFVW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="351" mass="39140" checksum="726B5C7835F4324E" modified="2000-10-01" version="1">MNKIKNAKSSFLYFKKMHNLKSFNKKRNRLKGIQIIFIVFLIIFCSLFFLIDLFFTGNHLNVIKRMFENSSLSNSTYIFVPVANIITGFSLGIGSISIQITSKNILAGPSTLGFTPMAILASTISFIITSSGIFSTILIYCLGLIFSFIIIGVNFILVRNNFLENSFKPILVAFGIGALVTGINIVLIATHDNLKIVGWWRFITINNTLINNYRMIVSSVLMIISTIILLFLSPYLNIIRKDYILAKSLGIKVNLIYWLVAICVVTITISSSILLGIIALLGVIVGIIIQTIFKKTHVLLLMILAGLFGSGILSFSSYINEYIPSAREMIICVFAIPVFAYILSKRKGFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX9</accession>
    <name>Q9PPX9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU510.1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU510.1"/>
    <dbReference type="EnsemblBacteria" id="AAF30923">
        <property type="protein sequence ID" value="AAF30923"/>
        <property type="gene ID" value="UU510.1"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU510.1"/>
    <dbReference type="HOGENOM" id="CLU_2037069_0_0_14"/>
    <dbReference type="OMA" id="QTHDYCL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="121" mass="14386" checksum="845DEEB447C5908C" modified="2000-10-01" version="1">MMKKWISISLLGFLLSLLIAIGVMFGFKNKKYFKTTLNIQTKLSIITKNNYEKIKTKKQLEIKIKNLTYYVKFKFLKQTHDYCLIKIFLSLKTDQKMIDISIYTNTQPLIESIINNFKLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY0</accession>
    <name>Q9PPY0_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ABC-2</name>
        <name evidence="10" type="ordered locus">UU510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689049.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU510"/>
    <dbReference type="TCDB" id="3.A.1.112.6">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30922">
        <property type="protein sequence ID" value="AAF30922"/>
        <property type="gene ID" value="UU510"/>
    </dbReference>
    <dbReference type="GeneID" id="29672303"/>
    <dbReference type="KEGG" id="uur:UU510"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.529"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_95_3_14"/>
    <dbReference type="OMA" id="YNDCSIA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="9">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="157"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAF30922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="658" mass="77366" checksum="2ACFBCA39A3E860A" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPY2</accession>
    <name>Q9PPY2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsK</name>
        <name evidence="4" type="ordered locus">UU508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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</entry>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        </source>
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        </source>
    </evidence>
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</entry>
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    <accession>Q9PPZ3</accession>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="377" mass="42988" checksum="7CCD133C9982A16A" modified="2000-10-01" version="1">MKKNTHKKLLPLISIFVLIPLSSLVVMCSKTKTKIVKEQKQITASSLRSTDIDLTSINLEIYFAKFDVNDILVKKFSIELEDDKGNKINVDINPEYNKNLQMLSFKLENLKPNTTYKITKFNITGHEVDLTQIKDSLFTTKAENLLPDIPNLPNSVGIEIKDIKTNSLSNDATKVNVNVNLEINQSTLENQYARLVYKSNDNSWKLSNTLKIAEIKNSNFVLDGLISNRKYLFKELIIGSQSDLNLTNAQTKITTNNELSFTTAPKPVEIKSVLIDTKFDNHPSSLINLKFNDSENNLKENDILKIKYKKVGPNEVIFEKTVRLANNFELLFEIENTKKNEKYEILSLESNTKHGYNVAPSIFNFISNDLRTFEIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPZ4</accession>
    <name>Q9PPZ4_UREPA</name>
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        </submittedName>
    </protein>
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    </gene>
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                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
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        <location>
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            <end position="217"/>
        </location>
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        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
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            <end position="402"/>
        </location>
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    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="449"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="543"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="649"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="2">
        <location>
            <begin position="744"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="805" mass="92250" checksum="4DAEF12FE298A904" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPZ7</accession>
    <name>SYG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyQS</name>
        <name type="synonym">glyS</name>
        <name type="ordered locus">UU493</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891800.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PPZ7"/>
    <dbReference type="SMR" id="Q9PPZ7"/>
    <dbReference type="STRING" id="273119.UU493"/>
    <dbReference type="PRIDE" id="Q9PPZ7"/>
    <dbReference type="EnsemblBacteria" id="AAF30905">
        <property type="protein sequence ID" value="AAF30905"/>
        <property type="gene ID" value="UU493"/>
    </dbReference>
    <dbReference type="GeneID" id="29672356"/>
    <dbReference type="KEGG" id="uur:UU493"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.510"/>
    <dbReference type="eggNOG" id="COG0423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_0_14"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000072987" description="Glycine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="214"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="219"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="289"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="329"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="333"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <sequence length="473" mass="55576" checksum="93CEAB38D5BABF66" modified="2000-10-01" version="1">MRYKFKTQEDLVNHLKSVGFVFANSEIYNGLANAWDYGPLGVLLKNNLKNLWWKEFVTKQKNIVGLDSAIILNPLVWKASGHLDNFSDPLIDCKSCKTRYRADKLIESFNKDIHIAENSTNEEFMKVLNDHKIFCPTCKQFNWTDIRHFNLMFKTHQGVIEDPKNIVYLRPETAQGIFVNFKNVQRSMRLHLPFGIAQIGKSFRNEITPGNFIFRTREFEQMEIEFFLKEEIAYDVFDKYLNQIQNWLVTCCGLDLNNLRKHEHPKEELSHYSKKTIDFEYNFLHGFSELYGIAYRTNYDLSVHMNLSKKDLTYFDEETKQKYIPHVIEPSVGVERLLYAILTEATFIEKLANDEDRILMNLKYDLAPYKIAVMPLVNKLKEKAEAVYNKILDLNISVTFDNSGSIGKRYRRQDAIGTIYCITIDYDSFGDEHDPTFTIRERNTMAQKRIKLSELSLYLSQKAHEDFQKQCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ04</accession>
    <name>Q9PQ04_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane nuclease A-hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mnuA-2</name>
        <name evidence="2" type="ordered locus">UU486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026782.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU486"/>
    <dbReference type="EnsemblBacteria" id="AAF30898">
        <property type="protein sequence ID" value="AAF30898"/>
        <property type="gene ID" value="UU486"/>
    </dbReference>
    <dbReference type="GeneID" id="29672587"/>
    <dbReference type="KEGG" id="uur:UU486"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046842_0_0_14"/>
    <dbReference type="OMA" id="WNVLNYS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="434" mass="50214" checksum="50747538D0CD8B94" modified="2000-10-01" version="1">MKNNKSRKWVITISLTLLIILIASAVIGVVFYLKNKKKNDTSVNNDSYIIQNNNNSLKEQPNSTRSFLNQKTICVGHWNVLNQGGINQLKNEALAKVILKSNVDVIALTEINSAKNNEHDDLPMRAILKELNLHKNQFDQTANWNYVLSKNLFSKGNESQTERIGFFYKANIIKPVQEYIYKNNDNKDILFEQYFKNWNDNTKITYSRPPYAYEFQTLDNKFNFTIVASHLDSPGANEHKTSKHDHTYGNKNLKINIKQGSKELNEAYQLGNVMDYIDRLDGNNDDLIFVGDTNIKTKNELGAFASLYKRNYLSNFKDDNENNKTTLAKTYLKYAQHYDKIFTSPSIKVLNTYKYDLWSVSLTNTLLDKNWKLAFLKTYFRSLSNQQMQNIVDNWDEIAKSNDVYIKKATSIISDHTLVAVNIKIDENDIIDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ05</accession>
    <name>Q9PQ05_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891796.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30897">
        <property type="protein sequence ID" value="AAF30897"/>
        <property type="gene ID" value="UU485"/>
    </dbReference>
    <dbReference type="GeneID" id="29672366"/>
    <dbReference type="KEGG" id="uur:UU485"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.502"/>
    <dbReference type="HOGENOM" id="CLU_391250_0_0_14"/>
    <dbReference type="OMA" id="HESSDSW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="264"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="705" mass="81347" checksum="B6A8A041DA8A7309" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ08</accession>
    <name>Q9PQ08_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30894">
        <property type="protein sequence ID" value="AAF30894"/>
        <property type="gene ID" value="UU482"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU482"/>
    <dbReference type="eggNOG" id="ENOG5033T9P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_223517_0_0_14"/>
    <dbReference type="OMA" id="EGECNNE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009849">
        <property type="entry name" value="DUF1410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07198">
        <property type="entry name" value="DUF1410"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="169"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="361"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="458"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="553"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="662"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="764"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="861"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="1316"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1410" evidence="1">
        <location>
            <begin position="3416"/>
            <end position="3465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="4688" mass="534883" checksum="B53ABFAFFEE1997E" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ14</accession>
    <name>Q9PQ14_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891790.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU476"/>
    <dbReference type="REBASE" id="18400">
        <property type="entry name" value="UurORF477P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30888">
        <property type="protein sequence ID" value="AAF30888"/>
        <property type="gene ID" value="UU476"/>
    </dbReference>
    <dbReference type="GeneID" id="29672338"/>
    <dbReference type="KEGG" id="uur:UU476"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.492"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319783_0_0_14"/>
    <dbReference type="OMA" id="QIENEGY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ResIII" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="825" mass="97510" checksum="8CB79F42D9FB6272" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ26</accession>
    <name>Q9PQ26_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891783.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU464"/>
    <dbReference type="EnsemblBacteria" id="AAF30876">
        <property type="protein sequence ID" value="AAF30876"/>
        <property type="gene ID" value="UU464"/>
    </dbReference>
    <dbReference type="GeneID" id="29672235"/>
    <dbReference type="KEGG" id="uur:UU464"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.480"/>
    <dbReference type="eggNOG" id="ENOG50345FH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095608_0_0_14"/>
    <dbReference type="OMA" id="EVWATIK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035325">
        <property type="entry name" value="DUF5385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17359">
        <property type="entry name" value="DUF5385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="241" mass="28467" checksum="ACF9A90190B9118A" modified="2000-10-01" version="1">MLDNQEIIESILQADSAKGGNGNFLMILIIIIPIVLVVVFIMRKKRKQNGENQTSVNNKDKSDTNEVWTTIKKYLRSIDDKGKEVIDSYVVKRAEPHNLVQMTKQQRIDYKNEQKAIKALKTTNPEQYKIEMERIKKEKRAKPKELYVVLFTTRNAKTLIIDEPRAIECEVRLVKINKKENRREIDVVRALDYEEEMLWIEPIKAKDDEIYNKRLEADKKKQQKAAQRRQKQLEKQKNKTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-06-20" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ27</accession>
    <name>FMT_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">UU463</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891782.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ27"/>
    <dbReference type="SMR" id="Q9PQ27"/>
    <dbReference type="STRING" id="273119.UU463"/>
    <dbReference type="EnsemblBacteria" id="AAF30875">
        <property type="protein sequence ID" value="AAF30875"/>
        <property type="gene ID" value="UU463"/>
    </dbReference>
    <dbReference type="GeneID" id="29672150"/>
    <dbReference type="KEGG" id="uur:UU463"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.479"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_14"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000083078" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="305" mass="34793" checksum="54E5676DE3291240" modified="2000-10-01" version="1">MKYKVMFFGTPEIAKIVLETLFNMHEVDLIAVVSQPDAHFDRKKNVIYSPVKQFCLDHNIKLFQPEKIKEIEEEIRILGPDIIITCAFGQFINQGIIDIPKYKIVNIHASLLPKLRGGAPIHYAILNGELKTGITLMHTIKKMDAGNILFQRSLEINDCTTTKSLTLELANLSALMIKEHFLELVKPNLVGIQQDENSVSFAYNIQKDQNIINFDQPAFFINRFVNAMYDKPIAIMQYNGVSIKVYQVKITNQKSCQKPGTIMIFKNQLFVSTQDFDIELLLIQLPNKKPLSPKVLLNGKNPFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ30</accession>
    <name>Q9PQ30_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nadE</name>
        <name evidence="7" type="ordered locus">UU460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="5"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689045.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU460"/>
    <dbReference type="EnsemblBacteria" id="AAF30872">
        <property type="protein sequence ID" value="AAF30872"/>
        <property type="gene ID" value="UU460"/>
    </dbReference>
    <dbReference type="GeneID" id="29672745"/>
    <dbReference type="KEGG" id="uur:UU460"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.476"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_14"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="255" mass="30078" checksum="F728C22C110B92D8" modified="2000-10-01" version="1">MNNDLIKYLQWLKNDFIKFLNDAQTNNVILGISGGIDSTLTLAILNDLKKEYDLNIYAYFLDIHNSSLDYECINELKNIYPNIEVINLVDIYDSYCKMINKKTNDKYVLYNLKPKIRTNYLYAMANAYKGVVVSNLNYDEYILGFFTKYGDSAADYYMLIGLLKKHIYELGAYYHLPNKILNRAPTPANEDDEHKTDESFFGFTYNDLDQFLLYRKINPKIVSMIKKRYETNAHKHFVFDKKKLFLNYKLGNKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ37</accession>
    <name>Q9PQ37_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688443.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU453"/>
    <dbReference type="EnsemblBacteria" id="AAF30865">
        <property type="protein sequence ID" value="AAF30865"/>
        <property type="gene ID" value="UU453"/>
    </dbReference>
    <dbReference type="GeneID" id="29672608"/>
    <dbReference type="KEGG" id="uur:UU453"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.469"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_1_14"/>
    <dbReference type="OMA" id="MKLDSMY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="155" mass="17835" checksum="05DCA9339B256942" modified="2000-10-01" version="1">MASYNINDNLLLRKIIMQHYEHPKNKVCFVQDEINYLSYHNTTEGCGDDITVYVKLNHQKIIDVVFLGTGCAISISSTDIICELVKNLDLNNALLLINNYLNMIEGLDYNKDIMQELIAFYNVKKQMNRIRCARIGASALKMCLKQFTDKHKTIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-04-03" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ42</accession>
    <name>RUVB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvB</name>
        <name type="ordered locus">UU448</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689015.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ42"/>
    <dbReference type="SMR" id="Q9PQ42"/>
    <dbReference type="STRING" id="273119.UU448"/>
    <dbReference type="EnsemblBacteria" id="AAF30860">
        <property type="protein sequence ID" value="AAF30860"/>
        <property type="gene ID" value="UU448"/>
    </dbReference>
    <dbReference type="GeneID" id="29672567"/>
    <dbReference type="KEGG" id="uur:UU448"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_14"/>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000165626" description="Holliday junction ATP-dependent DNA helicase RuvB">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <sequence length="312" mass="36106" checksum="C80407F98740ED3F" modified="2000-10-01" version="1">MKTNYEFRPQYLKDFIGKEQLKNNLKVYLTASKRLENSFDHTLLHGLSGTGKTTLALIIANEMNVNCHITQGNLLNKPIDIINLLSLIKENDVVFIDEIHACGLGAFETLYSVLEDFCIDINIGKDFNSKMTRLKIPHFTLIGATTIFGKIPKSLEERFGHIFHLNEYEPSEISAIILKNNQMHFQIDLNEEEIDLIANNAKGIPRLANRLLKRVVDFKINGFNDIKNIFKKIQIYEFGLDEQDINYLNVLYRQDNEIGLKSIAQILRLDQYTIETKIEPYLIQHHFINKNLRGRKITIEGIDFLKNNQLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ43</accession>
    <name>Q9PQ43_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type I restriction enzyme S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsdS-5</name>
        <name evidence="4" type="ordered locus">UU447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="REBASE" id="18404">
        <property type="entry name" value="S.UurORF466P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30859">
        <property type="protein sequence ID" value="AAF30859"/>
        <property type="gene ID" value="UU447"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU447"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2002914_0_0_14"/>
    <dbReference type="OMA" id="KSVRIGM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="124" mass="14815" checksum="D0B61DF93F74622B" modified="2000-10-01" version="1">MPPLDEQQRIVDKINLLEFFIKQYDEIEQKLSKLENEFPEKLKKSVLQYAMQGKLIKQDPNDDSIKDLLKQIHKEKQKLYKEGKLKKKDLEESIIYKSDDKSYYENIGNNEPKKLENLPFNINV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-11-16" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ75</accession>
    <name>EX53_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>5'-3' exonuclease</fullName>
            <ecNumber>3.1.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">polA</name>
        <name type="ordered locus">UU414</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">5'-3' exonuclease acting preferentially on double-stranded DNA.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.-"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688635.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ75"/>
    <dbReference type="SMR" id="Q9PQ75"/>
    <dbReference type="STRING" id="273119.UU414"/>
    <dbReference type="EnsemblBacteria" id="AAF30825">
        <property type="protein sequence ID" value="AAF30825"/>
        <property type="gene ID" value="UU414"/>
    </dbReference>
    <dbReference type="GeneID" id="29672547"/>
    <dbReference type="KEGG" id="uur:UU414"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_1_5_14"/>
    <dbReference type="OMA" id="WRVDLIP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000101289" description="5'-3' exonuclease">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exonuclease" evidence="2">
        <location>
            <begin position="176"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <sequence length="289" mass="32944" checksum="26E747EF0FE5CEDF" modified="2000-10-01" version="1">MKKAIVIDGNSLIYRAFHATYKQAEWAVEKQLMPTNAIKLVASMIFKILNQEQFTYGLIAMDASKQTFRAQEYAAYKATRKPMDAKLIVQLPYLKKLFVAMGFRIISQPGIEADDFVGSFSNLMNKFDVDTTIYSSDRDMLQLINKNTKLKLLKTGTSVMQEINLTNFSLLNNGILPYQIIEYKGLVGDSSDNLIGVKGIGPKTAINLLLKYDNIENIYTNLEKIAPSVKNKLIEHKDMAFLSKKLAAIQTDLLFDEKLENFVLKPYNTQELDELFTSLKINNMQNYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ77</accession>
    <name>Q9PQ77_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine adenosyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">metK</name>
        <name evidence="19" type="ordered locus">UU412</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688973.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU412"/>
    <dbReference type="EnsemblBacteria" id="AAF30823">
        <property type="protein sequence ID" value="AAF30823"/>
        <property type="gene ID" value="UU412"/>
    </dbReference>
    <dbReference type="GeneID" id="29672459"/>
    <dbReference type="KEGG" id="uur:UU412"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.428"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_14"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13 14" id="KW-0630">Potassium</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="16">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="17">
        <location>
            <begin position="109"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="18">
        <location>
            <begin position="225"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AAF30823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="376" mass="41988" checksum="433D7CB35D9228C1" modified="2000-10-01" version="1">MKYKKIITSESVGAGHPDKICDQISDAILDECLAQDKNSRVACEVLACNRLIVIAGEITTHAYVDVVKTAWEIIKPLGYNENDFTIISNVNKQSVDIAQSVNKANKDLIGAGDQGIVFGYACDETPQYMPLTTVLAHELLKEIEKQRRNKEFVKIQADMKSQVSIDYSNCTPVIETMLVSIQHDEDYNIEYFNKKVSTIMDQIAIKYGLNTDFKKIINSSGRFVIGGPIGDTGLTGRKIIVDTYGGIGHHGGGAFSGKDPTKVDRSASYFARWIAKNVVAAKLAKQCEIQLAFAIGEPQPVAMFVNTFKTNLVDEKKIFEAINKSFNFDIKTFINDLELWTTKYLPVATYGHFGRDDLNLSWEKLNKVQDLIKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ87</accession>
    <name>Q9PQ87_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688476.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU403"/>
    <dbReference type="EnsemblBacteria" id="AAF30813">
        <property type="protein sequence ID" value="AAF30813"/>
        <property type="gene ID" value="UU403"/>
    </dbReference>
    <dbReference type="GeneID" id="29672315"/>
    <dbReference type="KEGG" id="uur:UU403"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.418"/>
    <dbReference type="HOGENOM" id="CLU_933652_0_0_14"/>
    <dbReference type="OMA" id="NQANHIN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="298" mass="33851" checksum="5CEB25AA098F240D" modified="2000-10-01" version="1">MKKAILISISSLIGISAIVATSTFLSLSAKTNIYAKLIKSSDLNQSLNYTNLSDANIGIKEMLLGTNKINNGNYVLYIGTQSNLDNLNFVYDNQTNHINSISDLKYNDNLKFNGSLAKSINNVKNYADKGVYEHVPEFYSFIDLMDTNVFKQKQDYENLIKQNKSSTIKEDQNWANNAPTDYSFDVNKKYKDKSGREVYFRNDTQAVKFREILNFLKKYLSKEKLIELSTSQTPGIVLFYSQDNLSKGPQVYASSKIYDKSKNERKESYVSGDNVYNSSRFEFGGDLNAAIYSVYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ91</accession>
    <name>Q9PQ91_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hemin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hmuU-2</name>
        <name evidence="8" type="ordered locus">UU399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891760.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU399"/>
    <dbReference type="EnsemblBacteria" id="AAF30809">
        <property type="protein sequence ID" value="AAF30809"/>
        <property type="gene ID" value="UU399"/>
    </dbReference>
    <dbReference type="GeneID" id="29672211"/>
    <dbReference type="KEGG" id="uur:UU399"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.414"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064507_0_0_14"/>
    <dbReference type="OMA" id="SFRMPRI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="348" mass="39090" checksum="A4BF32AC4119D560" modified="2000-10-01" version="1">MKMKFNFFKDKQNILGQNHILELNKKSFIPYHFKPLLITITLLIALLVVIILIFSVTLSNKLGFSELAKVIWQEVVQLIITGVALGVSSYVLQRITRNRFADVSIMGIGTINLILLCALSIPVDFTSANELSILQKKEPWIFMFMSCCLMVLYFFVSRQKENFNYKKLILIGVILTFFLIAIAQSIRGWLNYHANDYVVGHIVGSVQKAPLNSLIIAASFVILGLLWLLFNSYKLNIIATNQQVAKQLGIKINFQIFIALIFVGIMVGASYSISGDFVYVGLLAGNAAMRRRNNSFTYGILNSGIYGMLSTLITYWIGISLIGMSVYHVGAILPLLIGPYFIYKVLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ99</accession>
    <name>Q9PQ99_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent serine proteinase-heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">clpB</name>
        <name evidence="7" type="ordered locus">UU391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689023.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU391"/>
    <dbReference type="EnsemblBacteria" id="AAF30801">
        <property type="protein sequence ID" value="AAF30801"/>
        <property type="gene ID" value="UU391"/>
    </dbReference>
    <dbReference type="GeneID" id="29672472"/>
    <dbReference type="KEGG" id="uur:UU391"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.406"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_14"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="49"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="451"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="6">
        <location>
            <begin position="612"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="264"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="704" mass="80559" checksum="C11926CBDEC4B0FB" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA1</accession>
    <name>Q9PQA1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688704.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU389"/>
    <dbReference type="EnsemblBacteria" id="AAF30799">
        <property type="protein sequence ID" value="AAF30799"/>
        <property type="gene ID" value="UU389"/>
    </dbReference>
    <dbReference type="GeneID" id="29672367"/>
    <dbReference type="KEGG" id="uur:UU389"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.404"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005128_0_0_14"/>
    <dbReference type="OMA" id="WRERNND"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025103">
        <property type="entry name" value="DUF4011"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13195">
        <property type="entry name" value="DUF4011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="1">
        <location>
            <begin position="331"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="2">
        <location>
            <begin position="948"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1284" mass="151797" checksum="C64664C562158AAD" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQA3</accession>
    <name>Q9PQA3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688645.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU387"/>
    <dbReference type="EnsemblBacteria" id="AAF30797">
        <property type="protein sequence ID" value="AAF30797"/>
        <property type="gene ID" value="UU387"/>
    </dbReference>
    <dbReference type="GeneID" id="29672305"/>
    <dbReference type="KEGG" id="uur:UU387"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.402"/>
    <dbReference type="HOGENOM" id="CLU_700092_0_0_14"/>
    <dbReference type="OMA" id="CLANVIT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="393" mass="46860" checksum="4B302DE5CBD0B5AB" modified="2000-10-01" version="1">MNKPMCLLRLDNYYFTLLVFIYNDVTKVNDLIFIKSIPNNNQNNYESSNFLQTDLKIQLNTLINCFKKELHINFIDEIIVSYGFSSFQTTHTTFYNYNEFMKLRSNFNNEHSELLSSDQKSYIAVDFGISHYSKENSYKLISYYILKYDYQLIIDLCQSFNLKIKQFIVSQAHLNGLKFDNEDNKTSLLLELENFKINFRTYNEYNLISNVISETKNHFCLADIITQTAQSLNINPKKIESYFNDINYNNKKVIEINIDPKELFTYSFICGADIENTFLKIFKEHFEKSILSQFDHPLLDFNPKNLAFLFINTPFNNLNKIFYYFFSSYFKEVKIEVFQNKFFIYSNCYEYSNSQALAKQDFYNVHNMKNFDSFSNENILTKMHDQTINIKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB2</accession>
    <name>Q9PQB2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU379"/>
    <dbReference type="EnsemblBacteria" id="AAF30788">
        <property type="protein sequence ID" value="AAF30788"/>
        <property type="gene ID" value="UU379"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU379"/>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091027_0_0_14"/>
    <dbReference type="OMA" id="NECENLF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="183" mass="21905" checksum="AC3C0BD1A9793131" modified="2000-10-01" version="1">MSKNPYVINEWFMANVIHNIKELQTLTINKKIKIKDFDYLSYLPLVKDDPLASYFKSIYEQEVKRTKLVLAHNDFSINNILANECENLFILIDFEYSSRNLKDWDLFNFLRDLNDVQLNFGISFIKEKLGYDECLIYKYLFLTSYYGFLWATNAFLKTNELKIKIYGENAYQKADFYLQKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQB9</accession>
    <name>Q9PQB9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase-recombinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tnp-1</name>
        <name evidence="2" type="ordered locus">UU372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU372"/>
    <dbReference type="EnsemblBacteria" id="AAF30781">
        <property type="protein sequence ID" value="AAF30781"/>
        <property type="gene ID" value="UU372"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU372"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.386"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_4_3_14"/>
    <dbReference type="OMA" id="KHNDIFA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="207" mass="24663" checksum="E4E67A2047520ACC" modified="2000-10-01" version="1">MNKLGLLCEIRRSKRKREIKNVNATFKNLANRDYDGQMNDIYATDVTYIPSPTDVIENHVYLSVLLHHKTKKIVSWNLSKYNDTNLVLKHFKLTKFPKKFIVHSDHGYQYSSKEFLDYIDSINGTISMSRVGNSLDNREVEYFFSILKTEIFSNFFQKAKSLTFNELQIEIDKFINLYNNERFIKKFDLKTPQQMWDVYMNNKSIWV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-27" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQC8</accession>
    <name>ASNA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparagine synthetase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnA</name>
        <name type="ordered locus">UU363</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine</text>
            <dbReference type="Rhea" id="RHEA:11372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688600.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQC8"/>
    <dbReference type="SMR" id="Q9PQC8"/>
    <dbReference type="STRING" id="273119.UU363"/>
    <dbReference type="EnsemblBacteria" id="AAF30772">
        <property type="protein sequence ID" value="AAF30772"/>
        <property type="gene ID" value="UU363"/>
    </dbReference>
    <dbReference type="GeneID" id="29672372"/>
    <dbReference type="KEGG" id="uur:UU363"/>
    <dbReference type="eggNOG" id="COG2502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071543_0_0_14"/>
    <dbReference type="OMA" id="QSRICMF"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000195898" description="Aspartate--ammonia ligase">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00555"/>
        </source>
    </evidence>
    <sequence length="329" mass="38305" checksum="35B918086BB42CBD" modified="2000-10-01" version="1">MDQLQKAKINQTQKAIVEIKNSFQKHFAKNLNLSRVTAPLFVEGQSGLNDHLDHKQKAVSFYAKKLDKTLEIVQSLAKWKRLALLDYGFSLYEGLYTDMNAIRADDDIDEIHSIYVDQWDWEILINNQDCNLDFLKSIVNKIYSTIRIVQLEIDQLYNPKQIILPDSITFISSQELEDLYPHLSPSRREYEFAKIHKAIFIYQIGYPLKSGYIQSIRSPEYDNWNLNGDLIVYHKLNDQAIELSSMGIRVSKQDFIKQTNFANLKNDQENNFYHQMILNNQLPQTIGGGIGQSRLCMFLLNKKHIGEVQVSVWPNEYKDELLKKGIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE1</accession>
    <name>Q9PQE1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688536.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU350"/>
    <dbReference type="EnsemblBacteria" id="AAF30759">
        <property type="protein sequence ID" value="AAF30759"/>
        <property type="gene ID" value="UU350"/>
    </dbReference>
    <dbReference type="GeneID" id="29672378"/>
    <dbReference type="KEGG" id="uur:UU350"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.364"/>
    <dbReference type="eggNOG" id="COG2384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071037_2_1_14"/>
    <dbReference type="OMA" id="GTDHGYI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006901">
        <property type="entry name" value="TrmK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04816">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018637">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="221" mass="25764" checksum="54C429D18286113B" modified="2000-10-01" version="1">MNPKTRIAFIADLINDAQNVVDVGSDHAYLAKILLVNNKAQHVTNIEVNQGPLENGINNLTKNNLLKRTTNILNDGFKGLILEQTFDYCVIAGMGATSIIEILEQNKNQIKNYILQPNTQSYKIRKYLNNHSYQIKVEHIFVEKKIFYEIIICSKTINVPKLIEKDYYISSQMHKDSLNLYFKFLKRRYEYLKALDISLVSENIVKEYEYIKEFINEKNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE7</accession>
    <name>Q9PQE7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plsC</name>
        <name evidence="3" type="ordered locus">UU344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688748.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU344"/>
    <dbReference type="EnsemblBacteria" id="AAF30753">
        <property type="protein sequence ID" value="AAF30753"/>
        <property type="gene ID" value="UU344"/>
    </dbReference>
    <dbReference type="GeneID" id="29672465"/>
    <dbReference type="KEGG" id="uur:UU344"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.358"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_6_1_14"/>
    <dbReference type="OMA" id="HVNPWKM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="78"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="264" mass="30687" checksum="DBCE5727A07C74F7" modified="2000-10-01" version="1">MNFLKTLLWFVAYPFVALYIIIQMILAAMMANKYKNDPESVSVNERYKKIMGIIDAILYLKNIKVDLIGKENVSIKSMLYIGNHKSNGDPIVLLKALYQISPHNVRFVAKIELKKSFLKFLFNLIDVIYIDRNNLRQSISTINEQVNALKQDYRGLVIFPEGTRNFNHEFNEFKSGALTAAYNTLSSIQPFVIFNSQGSFEMKNDQKQKLRSNPFKTQHIKVSFLEPIHSFNYININKDILMRKIQSNIKKNYDELLKSTIKTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF2</accession>
    <name>DNAK_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dnaK</name>
        <name type="ordered locus">UU339</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688469.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQF2"/>
    <dbReference type="SMR" id="Q9PQF2"/>
    <dbReference type="STRING" id="273119.UU339"/>
    <dbReference type="EnsemblBacteria" id="AAF30748">
        <property type="protein sequence ID" value="AAF30748"/>
        <property type="gene ID" value="UU339"/>
    </dbReference>
    <dbReference type="GeneID" id="29672518"/>
    <dbReference type="KEGG" id="uur:UU339"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_14"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000078580" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="603" mass="65956" checksum="770750529F44CC04" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF6</accession>
    <name>Q9PQF6_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU335"/>
    <dbReference type="EnsemblBacteria" id="AAF30744">
        <property type="protein sequence ID" value="AAF30744"/>
        <property type="gene ID" value="UU335"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU335"/>
    <dbReference type="HOGENOM" id="CLU_410449_0_0_14"/>
    <dbReference type="OMA" id="DKWPEYN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="680" mass="80602" checksum="4B3E11EF4F9D271C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQF7</accession>
    <name>Q9PQF7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU334"/>
    <dbReference type="EnsemblBacteria" id="AAF30743">
        <property type="protein sequence ID" value="AAF30743"/>
        <property type="gene ID" value="UU334"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU334"/>
    <dbReference type="HOGENOM" id="CLU_190051_0_0_14"/>
    <dbReference type="OMA" id="VKYTESK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="86" mass="9629" checksum="3052ABBDD7D79F3A" modified="2000-10-01" version="1">MMNDSVKQTNNIDENQLKPTTKSFFDDKNNQLTKVLNIPSVVKYTESKIKKNGKNFSINLIITITTMFIVIGIIITIAIAIGIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG2</accession>
    <name>Q9PQG2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688610.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU329"/>
    <dbReference type="EnsemblBacteria" id="AAF30738">
        <property type="protein sequence ID" value="AAF30738"/>
        <property type="gene ID" value="UU329"/>
    </dbReference>
    <dbReference type="GeneID" id="29672430"/>
    <dbReference type="KEGG" id="uur:UU329"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.342"/>
    <dbReference type="HOGENOM" id="CLU_650431_0_0_14"/>
    <dbReference type="OMA" id="SYAHYEK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="422" mass="49219" checksum="8EA05B3F2F76C8E8" modified="2000-10-01" version="1">MLNAELSSAQKDLYKSIKLYLNTIFLNQKLNYAIKNDNDYRNQLNKVMNIFEYYEDNYEIANKNFHSYWQAFKSYVHYEKIVNDYNDFDELKDIVNGLKIYVLNTFQIDLDQESQRIADIDFKYDEKTQASMGFYTPRNQENNTSTEYEKVSAESISDEDSMNHTYQPTSDFTTANIDNLTNMVFSARVMNGEIYLYETKPKVIPFLKYVFFAVSLALVFFTTLTYAFLMDFGTHMSSVINVNGITHIVRLVSPTFPTQLVISIFIMIYAGINAFKRKISENEKFHFKNFIWIILFGALLVVALANIFTGNLRFSSSSFDEMFRQAQINDVLANLARNNSFSFDYSYLQSIFYGYSIAQILVFVVIILGTILIISTFILNPKRDIQRIKLLLQEIHDDILTGKIDPNTYLRTKNPFRDLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG4</accession>
    <name>Q9PQG4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoU-3</name>
        <name evidence="2" type="ordered locus">UU327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688821.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU327"/>
    <dbReference type="EnsemblBacteria" id="AAF30736">
        <property type="protein sequence ID" value="AAF30736"/>
        <property type="gene ID" value="UU327"/>
    </dbReference>
    <dbReference type="GeneID" id="29672477"/>
    <dbReference type="KEGG" id="uur:UU327"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.340"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_14"/>
    <dbReference type="OMA" id="FLAEGPQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="257" mass="29655" checksum="2940021CD58870E3" modified="2000-10-01" version="1">MLKIITSNKNEEIIHFYRLIHDKKYREANKLFIIEGFKLLDEALQNQQTIVSIIINEHVYNKEFETIFKYTLYDNIQIYKVSGNIIKKLSVNIEPSPILAVVKIKQEMCDINDNILLLDNIQDPGNLGTILRTCFAFNIKQVIFNNCVDLYNPKTIKASMGAIFKINFLRFNDSKLALNFLLKNKFYLIATILDKNAISLNEITIKQKYCLMVGNEGHGLVQTFIDHAHIKTMIKMNQTESLNVAVAAAIFLYELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQG9</accession>
    <name>Q9PQG9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU322"/>
    <dbReference type="EnsemblBacteria" id="AAF30731">
        <property type="protein sequence ID" value="AAF30731"/>
        <property type="gene ID" value="UU322"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU322"/>
    <dbReference type="HOGENOM" id="CLU_1874551_0_0_14"/>
    <dbReference type="OMA" id="CWITGIN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="156" mass="18382" checksum="79100AD9235B7F9E" modified="2000-10-01" version="1">MLIILMNYLKKLNNKKINYPMLKKQNKNKEQHWLEKHLRQKTGLIISWSIIFGVLVLLSIGFGLILHFFNSNNLSIQLSFIINLNKYLVNITKILDYIGFALIYLPIIFLLGCWITGINGVHESLYYHVFIWLFYFISVILLIITICLSIATHIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQI9</accession>
    <name>Q9PQI9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU302"/>
    <dbReference type="EnsemblBacteria" id="AAF30711">
        <property type="protein sequence ID" value="AAF30711"/>
        <property type="gene ID" value="UU302"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU302"/>
    <dbReference type="HOGENOM" id="CLU_2048711_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="120" mass="13888" checksum="7C3C573E438DC1B0" modified="2000-10-01" version="1">MKQRLINYIIVLIGILCIVSLVVGFAVWFSPNKNFDTLTQNKIDGNEVKRLYNPNNGIFLEQLEGFSKYNIAGYVVPIVFVILSFILLFLYYFLNKKSRSKADFPISEKFIITLQLPLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQJ9</accession>
    <name>Q9PQJ9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">UU292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU292"/>
    <dbReference type="EnsemblBacteria" id="AAF30701">
        <property type="protein sequence ID" value="AAF30701"/>
        <property type="gene ID" value="UU292"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU292"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234978_0_0_14"/>
    <dbReference type="OMA" id="AANDFME"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="92"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1830" mass="208972" checksum="22FA249D954A1ADB" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQL7</accession>
    <name>Q9PQL7_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxygen-independent coproporphyrinogen III oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hemN</name>
        <name evidence="2" type="ordered locus">UU274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688870.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU274"/>
    <dbReference type="EnsemblBacteria" id="AAF30683">
        <property type="protein sequence ID" value="AAF30683"/>
        <property type="gene ID" value="UU274"/>
    </dbReference>
    <dbReference type="GeneID" id="29672428"/>
    <dbReference type="KEGG" id="uur:UU274"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.283"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_2_2_14"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="354" mass="42166" checksum="B6B5DC84513FB8C9" modified="2000-10-01" version="1">MIFNKKTKHLYIHIPFCNYICIFSDFKRILKTPQTKKFFKNFLENIKMHINNFKIKQFKTIYLGGGVPNCLNNQELEILLKTISPYVDDNCEYTIECNPELINQTQINLFKKYKINRISLNVQSMNNDVLKQMNFIHTNQDSKKAINLLHKNGLYNVSCDFLFCISILTLKDLDDVFNFILNHKINHVSFYSLEIKEQSLLKKYHITIDEEKEIEQMNYIINKFAGLNFHRYEVCNWTNNFRYIAKHNLAYWRTEDWAAIGWGAHGYEKNIVYFFDGSIKNPILIKKVLTKHELYQQILMMGLRLKDGLNLNKKINYEAYSYFKNQLKHVSINKKNHLLIDDLNLLNLTILDIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQM2</accession>
    <name>TRMB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name type="ordered locus">UU269</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688874.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQM2"/>
    <dbReference type="SMR" id="Q9PQM2"/>
    <dbReference type="STRING" id="273119.UU269"/>
    <dbReference type="EnsemblBacteria" id="AAF30678">
        <property type="protein sequence ID" value="AAF30678"/>
        <property type="gene ID" value="UU269"/>
    </dbReference>
    <dbReference type="GeneID" id="29672514"/>
    <dbReference type="KEGG" id="uur:UU269"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_2_1_14"/>
    <dbReference type="OMA" id="WRGAKTA"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000171417" description="tRNA (guanine-N(7)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <sequence length="224" mass="26494" checksum="FB6152538C75CBBF" modified="2000-10-01" version="1">MRLRNNANAPLYLKSQHEYIINDPHLLKDNLGKIFKNPELPLYIEIGMGKGDFIIENALRNQQINYLGIEKFPTVIVKAHKKALKHKLDNLAMICFDANKILELLNSESVDKIYLNFSDPWPKKRHAKKRLTHPCFLEKFAVILKQNALVEFKTDNENLFMYTIYDVLLKDLTKYEILFLTYNLYTLVNNVELLKNIPTEYEKKFVMQGERIKKVNFRFLKNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQN2</accession>
    <name>Q9PQN2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689167.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU259"/>
    <dbReference type="EnsemblBacteria" id="AAF30668">
        <property type="protein sequence ID" value="AAF30668"/>
        <property type="gene ID" value="UU259"/>
    </dbReference>
    <dbReference type="GeneID" id="29672639"/>
    <dbReference type="KEGG" id="uur:UU259"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.268"/>
    <dbReference type="eggNOG" id="ENOG5033VQJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400529_0_0_14"/>
    <dbReference type="OMA" id="FAISHLF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027593">
        <property type="entry name" value="Aro_clust"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04313">
        <property type="entry name" value="aro_clust_Mycop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="621" mass="75135" checksum="5D82AFC1D775AA4B" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP0</accession>
    <name>KAD_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <shortName evidence="1">AK</shortName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">adk</name>
        <name type="ordered locus">UU251</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688832.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQP0"/>
    <dbReference type="SMR" id="Q9PQP0"/>
    <dbReference type="STRING" id="273119.UU251"/>
    <dbReference type="EnsemblBacteria" id="AAF30660">
        <property type="protein sequence ID" value="AAF30660"/>
        <property type="gene ID" value="UU251"/>
    </dbReference>
    <dbReference type="GeneID" id="29672664"/>
    <dbReference type="KEGG" id="uur:UU251"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_14"/>
    <dbReference type="OMA" id="MSPVIAW"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="SSF57774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000158881" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <sequence length="213" mass="24331" checksum="BDE1142C32F5C434" modified="2000-12-01" version="1">MKILLIGPPGSGKGSVSELLTKNNTLKHVSTGNLFRAILKEDSELARKIKEINVSGGKLVPDEITNQVAKSAIDELIKNEQSFILDGYPRTINQALALEQYCNLDYIFYLDIDHQELMKRLTGRWMCPKCAGIYNIHFKKPQVHGLCDNDQATLYQRADDHADAVSIRLDEYDKLTLPLIKHYETNPRFIKINANQPIEDVYKNINNYLKQNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ0</accession>
    <name>RL14_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">UU241</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026223.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ0"/>
    <dbReference type="SMR" id="Q9PQQ0"/>
    <dbReference type="STRING" id="273119.UU241"/>
    <dbReference type="EnsemblBacteria" id="AAF30650">
        <property type="protein sequence ID" value="AAF30650"/>
        <property type="gene ID" value="UU241"/>
    </dbReference>
    <dbReference type="GeneID" id="45015785"/>
    <dbReference type="KEGG" id="uur:UU241"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_14"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000055748" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="122" mass="13243" checksum="7B7B9D304CF60410" modified="2000-10-01" version="1">MIQHMTRLKVADNTGAKEVGVIKVLGGSKKRYASVGDIVVVSVKKATPAGLIAKGQMAKAVIVRTKKSIRRESGLLIRFDENACVLIKEDKTPRGSRIFGPVAREIRDRGYTKIASLAPEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-01-10" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQQ4</accession>
    <name>RS3_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name evidence="1" type="synonym">rps3</name>
        <name type="ordered locus">UU237</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026040.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQQ4"/>
    <dbReference type="SMR" id="Q9PQQ4"/>
    <dbReference type="STRING" id="273119.UU237"/>
    <dbReference type="EnsemblBacteria" id="AAF30646">
        <property type="protein sequence ID" value="AAF30646"/>
        <property type="gene ID" value="UU237"/>
    </dbReference>
    <dbReference type="GeneID" id="45015781"/>
    <dbReference type="KEGG" id="uur:UU237"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_14"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130229" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="257" mass="28858" checksum="259CF43E0118ACDD" modified="2000-10-01" version="1">MGQKVNPNGLRFGINKQWLSRWVPTDQLQMAKWLVEDDKIRKYLSTKYKNAGIDHVEIERDQQRVNVYVYAVQSGLLIGTEASEKKLIELAINKIVGRKQLVSLKVVEVQIPELQASLMAREIADAIENRVSFRIAQKMVIKKVLKAGARGIKTHVSGRLGGVEMAREEGYTQGVMTLHTLRADIDYSMQEAHTTYGIIGVKVWINRGELFGNKLVNSVAHAANKEFSRSSKPKKGSFNRSSRSKNTKPAPKQAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR9</accession>
    <name>Q9PQR9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xasA</name>
        <name evidence="6" type="ordered locus">UU223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU223"/>
    <dbReference type="EnsemblBacteria" id="AAF30631">
        <property type="protein sequence ID" value="AAF30631"/>
        <property type="gene ID" value="UU223"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU223"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358217_0_0_14"/>
    <dbReference type="OMA" id="VANEMQY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="759" mass="84714" checksum="14E879BF36A005CF" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQS8</accession>
    <name>Q9PQS8_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689138.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU214"/>
    <dbReference type="EnsemblBacteria" id="AAF30622">
        <property type="protein sequence ID" value="AAF30622"/>
        <property type="gene ID" value="UU214"/>
    </dbReference>
    <dbReference type="GeneID" id="29672673"/>
    <dbReference type="KEGG" id="uur:UU214"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.222"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_2_0_14"/>
    <dbReference type="OMA" id="KVVFMGM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="336" mass="39300" checksum="13415DB7612C26CA" modified="2000-10-01" version="1">MKLNNHNLKEIYSLSLNELKEELFKLGLKSFISKQIYSWIYQKRIFNFDKFSNIAKNNVIILKENFSNNLLKINSYQSNSDGSIKFEFLTDKNLIINCMIIKFKNGFLIKINPFGINFKKEIINLSTNELVLQILLIQQFLDQRKLGNITNVIIKGLQDSLLNMDVVSNFINIINNENGLNIGKRKIAVWTSGINVDLIKWGQLQNQIELIISMNASNSLIYQKIMLKKLNQNWSFLKLIEQIKAYTKITNNRVVLEYLLIDKINDDLNYANELVELLKNILCYVLLIPYNLNNYRTSANLDDFFNILSVNKIRISKRIRKSNDLDISFKQLKIKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT2</accession>
    <name>RL27_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmA</name>
        <name evidence="1" type="synonym">rpl27</name>
        <name type="ordered locus">UU210</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688856.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQT2"/>
    <dbReference type="SMR" id="Q9PQT2"/>
    <dbReference type="STRING" id="273119.UU210"/>
    <dbReference type="EnsemblBacteria" id="AAF30618">
        <property type="protein sequence ID" value="AAF30618"/>
        <property type="gene ID" value="UU210"/>
    </dbReference>
    <dbReference type="GeneID" id="29672654"/>
    <dbReference type="KEGG" id="uur:UU210"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_14"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000181200" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="100" mass="10982" checksum="A34788D0C88594CA" modified="2000-10-01" version="1">MNKLYWLTDLQLFASKKGVGSSKNGRDSNPKYLGAKLGDGQSTKAGQIIYRQRGNKIYPGLNVGQGKDHTLFAKTAGVVKYTKFMGDKTKVSVLPKEDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-02-26" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT4</accession>
    <name>Q9PQT4_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU209"/>
    <dbReference type="EnsemblBacteria" id="AAF30616">
        <property type="protein sequence ID" value="AAF30616"/>
        <property type="gene ID" value="UU209"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU209"/>
    <dbReference type="HOGENOM" id="CLU_1337040_0_0_14"/>
    <dbReference type="OMA" id="WKNWDEI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="212" mass="25707" checksum="C6784C488EDB4899" modified="2000-10-01" version="1">MNINWKSMYKEILIRNSDLNYIVSDPFENMIGGFPIILFENDNYIYYLSGQNAYLPSKMRRWKNWDEILINKNDLLKENFIYKDIYINLFQIYVTKKNNLSRYLSNQFNFTLTKNDFKDELWNKLIYNTIKKLINNSNPQILLFEISRNKKQKYHSLLLFADKNVLKKFYLNSATKDNYEDIIDLAFNKFENLQNLLKTTKVKNHLKNLKKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQT9</accession>
    <name>RS15_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name evidence="1" type="synonym">rps15</name>
        <name type="ordered locus">UU204</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004025791.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQT9"/>
    <dbReference type="SMR" id="Q9PQT9"/>
    <dbReference type="STRING" id="273119.UU204"/>
    <dbReference type="EnsemblBacteria" id="AAF30611">
        <property type="protein sequence ID" value="AAF30611"/>
        <property type="gene ID" value="UU204"/>
    </dbReference>
    <dbReference type="GeneID" id="45015745"/>
    <dbReference type="KEGG" id="uur:UU204"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_1_0_14"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000115580" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10074" checksum="DB2D2DEF16DE3BC2" modified="2000-10-01" version="1">MAVSKQQKHDLTVKFGGSASNTGKTEVQVAILSAEIDSLTTHMIENKKDKASKRGLYKKVAQRKKLLSYLQRVDIERYRALIKELNLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU1</accession>
    <name>Q9PQU1_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688893.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU202"/>
    <dbReference type="EnsemblBacteria" id="AAF30609">
        <property type="protein sequence ID" value="AAF30609"/>
        <property type="gene ID" value="UU202"/>
    </dbReference>
    <dbReference type="GeneID" id="29672604"/>
    <dbReference type="KEGG" id="uur:UU202"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.209"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2686769_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="74" mass="8459" checksum="9A25D3A2F80980A7" modified="2000-10-01" version="1">MTYMLLTSSDLHCGSCSSNLYNVLEKIGAQNISVNILNSEFAFEFEENKIADQDVIKEINKNGFKTNILEKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU8</accession>
    <name>Q9PQU8_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">UU195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688957.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU195"/>
    <dbReference type="EnsemblBacteria" id="AAF30602">
        <property type="protein sequence ID" value="AAF30602"/>
        <property type="gene ID" value="UU195"/>
    </dbReference>
    <dbReference type="GeneID" id="29672744"/>
    <dbReference type="KEGG" id="uur:UU195"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.202"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_4_0_14"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAF30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="279" mass="32263" checksum="C07206D9D670D948" modified="2000-10-01" version="1">MKLCDKEYILSVIATPIGNLEEVSERVIKCLNEAYVILCEDTRVTAKLLHLLNIYDYKKLISYHNFNEIQKLNEAINYIKKYPTALVSDAGYPTISDPGYKLINECHQQNIGIQVINGPSSLMHALVASGMCSQDFMFLGFLGKTQKQRVEKLKLYKNLQTTFVIYEAVHRIEKTLMDIYEIWGDILIFIGRELTKKNESHYYGYLSQLPPITEKGEFVIVIDNKINQDVIKNNNINECLIKIRDLMKQNFKLKDACKEVSKSSNFDSKELYKLIINQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQV5</accession>
    <name>RPOC_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">UU188</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891704.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQV5"/>
    <dbReference type="SMR" id="Q9PQV5"/>
    <dbReference type="STRING" id="273119.UU188"/>
    <dbReference type="EnsemblBacteria" id="AAF30595">
        <property type="protein sequence ID" value="AAF30595"/>
        <property type="gene ID" value="UU188"/>
    </dbReference>
    <dbReference type="GeneID" id="29672692"/>
    <dbReference type="KEGG" id="uur:UU188"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.195"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_14"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000067826" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="922"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="997"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1004"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1007"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <sequence length="1305" mass="147970" checksum="BB3C3938B7CC866F" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX3</accession>
    <name>Y170_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU170</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU170</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891700.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQX3"/>
    <dbReference type="EnsemblBacteria" id="AAF30577">
        <property type="protein sequence ID" value="AAF30577"/>
        <property type="gene ID" value="UU170"/>
    </dbReference>
    <dbReference type="GeneID" id="29672666"/>
    <dbReference type="KEGG" id="uur:UU170"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.177"/>
    <dbReference type="HOGENOM" id="CLU_1767265_0_0_14"/>
    <dbReference type="OMA" id="CRNASYD"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220827" description="Uncharacterized protein UU170">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <sequence length="147" mass="17499" checksum="CFB204B8EDC74E54" modified="2000-10-01" version="1">MMKRNELKQLQELQLKINDFYTLVMTTKNLDLCNLSALLEFLGINWGVWVNLSTQRDEFNKKRYEYITKANYGLRMALNELLGRNASYDKEINNQGLRKFRTQEYFKRLDFELANEQKSTDIEDTTITFEKVDDNNKLTIKKLINVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQX5</accession>
    <name>Y168_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU168</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU168</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQX5"/>
    <dbReference type="STRING" id="273119.UU168"/>
    <dbReference type="EnsemblBacteria" id="AAF30575">
        <property type="protein sequence ID" value="AAF30575"/>
        <property type="gene ID" value="UU168"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU168"/>
    <dbReference type="HOGENOM" id="CLU_048575_0_0_14"/>
    <dbReference type="OMA" id="WIDEIQY"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220826" description="Uncharacterized protein UU168">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <sequence length="337" mass="39561" checksum="5AA0CBD2B2783200" modified="2000-10-01" version="1">MALKTNTIIKSKWNPSNFDINIDIKEMIARTAQESTVNDVILKTKDNVPLEWMEFIDNINENNEILKLIKGDCRIKSLYGINYVGFEIYNNDILIFNADINNAMNKSIRINQQQEYSSTIYRKIALMKDSEYLSLKELHTPYEIKRLIYNSTGVYKIIFNEFEVSTPMYFKDIFKNKNVVHNYGVLCTKEFLNRSFIDFENKINEKLPDWYPVNDLINDTNALLNFIKKERELNKTRIVGSIINHNDAQTYRNQWIDEIQYMSSDLILNTNTPDKNAFEIMQSTFNESIHLQAITEKLNLIFKGCGYVWNMGDSLSYQNSETATNLNKATFETQKWK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY3</accession>
    <name>Y161_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU161</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU161</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQY3"/>
    <dbReference type="STRING" id="273119.UU161"/>
    <dbReference type="EnsemblBacteria" id="AAF30567">
        <property type="protein sequence ID" value="AAF30567"/>
        <property type="gene ID" value="UU161"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU161"/>
    <dbReference type="HOGENOM" id="CLU_2157280_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220819" description="Uncharacterized protein UU161">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <sequence length="111" mass="13084" checksum="C7561110E1AB3560" modified="2000-10-01" version="1">MANHEVIFKWYLSLNFNNSSVDWSDKDYSLTFSFDRNTDRNNMLSDSGETQQQILLWNQYQPQFLVVRVNAEKSGVNVDLWLIDIVNKTFATNFEVGLNYEWSVRTIYVGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQY6</accession>
    <name>Y158_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU158</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU158</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026698.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQY6"/>
    <dbReference type="STRING" id="273119.UU158"/>
    <dbReference type="EnsemblBacteria" id="AAF30564">
        <property type="protein sequence ID" value="AAF30564"/>
        <property type="gene ID" value="UU158"/>
    </dbReference>
    <dbReference type="GeneID" id="45015942"/>
    <dbReference type="KEGG" id="uur:UU158"/>
    <dbReference type="HOGENOM" id="CLU_1767264_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220817" description="Uncharacterized protein UU158">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="147" mass="17616" checksum="4686CECF4438E47A" modified="2000-10-01" version="1">MTKQEFKAITKELFFFNKKRLMLWIAILIFVIAFAMIIVFVPFFNFNDKIKSLFDKLKHINWQDPTALFGLVFSVLGYLITALSIPLKVFELMLMLRFRLMLAKLIKDGILDPKAFIDDIRHSYLSRRKQRKLEEEIEYLKRIKSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR03</accession>
    <name>Q9PR03_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ordered locus">UU141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688880.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU141"/>
    <dbReference type="EnsemblBacteria" id="AAF30547">
        <property type="protein sequence ID" value="AAF30547"/>
        <property type="gene ID" value="UU141"/>
    </dbReference>
    <dbReference type="GeneID" id="29672363"/>
    <dbReference type="KEGG" id="uur:UU141"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.147"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_0_14"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="232"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAF30547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="351" mass="39550" checksum="F770EC21AB6041EF" modified="2000-10-01" version="1">MGFFKKIFNKILGKKDTEQISQEISQKNEENRILKLEDNSINKFNEGLRKSSSALTDAINELAVKYIDIDERWYEHLEEVLISYDVGYVATNKIIESIRNEMIYQKVNDPDLIKSIIIDKIFIYYIQDTEINTAINLKENQTNVVLVVGVNGVGKTTSIAKITKKFIDENKKVLLVAGDTFRAGAVEQLKVWAQRLGVDIELPNKEGQDPASVIYAGVKKGYEQKYDLVICDTSGRLQNKINLMNELKKIHDVIHKFDEYAPHETLLVLDATQGQSGINQAKAFNEVTKISGIILTKMDSTSRGGIVLAIKDAFNIPVKLIGLGEKLEDLSVFDLEMYVDSIVLGMKLDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR04</accession>
    <name>Q9PR04_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">p115</name>
        <name evidence="3" type="synonym">smc</name>
        <name evidence="5" type="ordered locus">UU140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688967.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU140"/>
    <dbReference type="EnsemblBacteria" id="AAF30546">
        <property type="protein sequence ID" value="AAF30546"/>
        <property type="gene ID" value="UU140"/>
    </dbReference>
    <dbReference type="GeneID" id="29672758"/>
    <dbReference type="KEGG" id="uur:UU140"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.146"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_14"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="417"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="168"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="563"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="765"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="981" mass="111674" checksum="119100B1C9880104" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR13</accession>
    <name>Y131_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU131</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU131</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR13"/>
    <dbReference type="STRING" id="273119.UU131"/>
    <dbReference type="EnsemblBacteria" id="AAF30537">
        <property type="protein sequence ID" value="AAF30537"/>
        <property type="gene ID" value="UU131"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU131"/>
    <dbReference type="HOGENOM" id="CLU_1057465_0_0_14"/>
    <dbReference type="OMA" id="GNDHSLM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220802" description="Uncharacterized protein UU131">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="268" mass="30686" checksum="01BDC28B5C9A4380" modified="2000-10-01" version="1">MNQIKMNKSFAEFSKLPKIKQVFTPWFIAALVIFIVGLTIAFTMVGLLNEGFENARALVNDQGQIIGKVADVSGDNHSLMSWLGYDQHANYQELYKTIHDQLINGKTMESLINNTNKNNDPKLYEALHYHAHSKFINHNGTWGFVTKVLSDWENSWFYKYNQLFSQLANSQNPVLAAQGIKSLAKLSTIIQYQNPNYIAYNWVFIVFMMPQMITFIIIVVKLATVFSPKKSAEEKQAYKLAKLEVKNQKKAKKLNNSLQQINLNLEAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR14</accession>
    <name>ATPG_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpG</name>
        <name type="ordered locus">UU130</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688922.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR14"/>
    <dbReference type="SMR" id="Q9PR14"/>
    <dbReference type="STRING" id="273119.UU130"/>
    <dbReference type="EnsemblBacteria" id="AAF30536">
        <property type="protein sequence ID" value="AAF30536"/>
        <property type="gene ID" value="UU130"/>
    </dbReference>
    <dbReference type="GeneID" id="29672729"/>
    <dbReference type="KEGG" id="uur:UU130"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_14"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000073409" description="ATP synthase gamma chain">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <sequence length="286" mass="32295" checksum="C9AE278976AAE4F5" modified="2000-10-01" version="1">MSLDAMKRKINSVQTTAKITNAMKLVATAKLKRQRDRLAAIKEYCHDYYDVIGLLLSVVDDVEFLKIPNAKDRTLYITINSTMGLAGSYNYNVNKLISKIVNETDITFTIGKKGHDFMRLSGRVDQVNTYLNLNDNDLTFDMSLQIAREALELYSQGEVNKICIIYTKFINAITFEVSVIDVLPFDKTALIKDHLAETIELAKDNIIFKPNKFELVKKILPTYIATVLYGSLIESKISENASRRNAMDAATKNAKALAENYKLIYNTLRQGKITREITEIVAGSDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR16</accession>
    <name>ATPE_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpC</name>
        <name type="ordered locus">UU128</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text>F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688897.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR16"/>
    <dbReference type="SMR" id="Q9PR16"/>
    <dbReference type="STRING" id="273119.UU128"/>
    <dbReference type="EnsemblBacteria" id="AAF30534">
        <property type="protein sequence ID" value="AAF30534"/>
        <property type="gene ID" value="UU128"/>
    </dbReference>
    <dbReference type="GeneID" id="29672196"/>
    <dbReference type="KEGG" id="uur:UU128"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1874552_0_0_14"/>
    <dbReference type="OMA" id="HNPLMSI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000188234" description="ATP synthase epsilon chain">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <sequence length="136" mass="15890" checksum="B46AA64185EC24CF" modified="2000-10-01" version="1">MANLTKLKIVTPYAQILEKDVYSVELKTSEGRITVLPDHNPLMSTIENHVAYIRELPNTPRKPLLLLDGIVYIEQHQVRVFSDYFKFLDEIQIDEINSSLNQLKHDLNNEEDDKKKLQLKSKIKLNESILIAYKDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR27</accession>
    <name>SYY_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="1">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tyrS</name>
        <name type="ordered locus">UU117</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688855.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR27"/>
    <dbReference type="SMR" id="Q9PR27"/>
    <dbReference type="STRING" id="273119.UU117"/>
    <dbReference type="EnsemblBacteria" id="AAF30523">
        <property type="protein sequence ID" value="AAF30523"/>
        <property type="gene ID" value="UU117"/>
    </dbReference>
    <dbReference type="GeneID" id="29672276"/>
    <dbReference type="KEGG" id="uur:UU117"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_2_14"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000234807" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="346"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <sequence length="415" mass="47115" checksum="5C4AE9D672228876" modified="2000-10-01" version="1">MHSLIKDLKARNLINNITNEEKLIKALEKNKGIYVGFDPSADSLHLGNYIMIMLLKRFRLYNIKTLALVGGATGMIGDPSGKSAERNLLDKTILEKNIAKIKFQLEKFTNSQVINNYVFYENMTFLDFLRDVGKLININYLLEKEIINSRLSVGISYTEFSYNLLQGYDFLQLYKNDNIAIQAGGSDQWGNITTGIEMIRKNLGDDNIACGLTINLLTNSEGKKFGKSEKGAIYLDENKSTVYEMYQFLINQSDADVEKLLNFLTLIDVEEIKKIMQAHKNNPALRVAQKALAKAVVVDIHGQQKYEQALHISEVLFNGSISTLNQEELEIAIKSLPATKLDKDEIKIIDLLNLANISSSNRIARDFLNTGSILINDIKINDENFLVKKQDAINQKFSIIRKGKRNYFLILWNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR31</accession>
    <name>Q9PR31_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pseudouridine synthase (Uracil hydrolase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sfhB</name>
        <name evidence="3" type="ordered locus">UU113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688664.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU113"/>
    <dbReference type="EnsemblBacteria" id="AAF30519">
        <property type="protein sequence ID" value="AAF30519"/>
        <property type="gene ID" value="UU113"/>
    </dbReference>
    <dbReference type="GeneID" id="29672748"/>
    <dbReference type="KEGG" id="uur:UU113"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.119"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_1_0_14"/>
    <dbReference type="OMA" id="HAFLVKF"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="315" mass="37672" checksum="C5E435A342B9F56E" modified="2000-10-01" version="1">MNLKEIKIKINDANQRLDRFLLKNFPNLSRIAVYKIIRTKDVKVNHKKVDHNYLLKENDVVSIYAKENFLEKKVDLSFANAKDELDIIYEDKNILVVHKPIGLIVHEDNRYKNDTLQNRIKKYLVKKDEYHPFDESAFVPSLCHRLDLNTSGLIVAAKTANALRVITEMFKNNDVIRIYKCLTYNQLPKNNDVIYNFMYKADDNTMIVQNFKTKFNKTAITKYTYIDKYKKYFIYDIELLTGRTHQIRAVLNFLHAPIVGEQKYITKDIDKNQNYMYQCLVSYKIKFINLKKYQCEELNYLENKEFRIKNIWFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR35</accession>
    <name>Q9PR35_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">potC</name>
        <name evidence="6" type="ordered locus">UU109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688519.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU109"/>
    <dbReference type="EnsemblBacteria" id="AAF30515">
        <property type="protein sequence ID" value="AAF30515"/>
        <property type="gene ID" value="UU109"/>
    </dbReference>
    <dbReference type="GeneID" id="29672201"/>
    <dbReference type="KEGG" id="uur:UU109"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.115"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_14"/>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAF30515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="284" mass="31784" checksum="4E84C47270D618BC" modified="2000-10-01" version="1">MKQINWLSWLRNFYIWIILAIIYIPLIIIVLLSFTTPSIKGNITSAFNWNDGSNYLTLTTNQFTDALINTIIISVIAVPISTIIATITCFGVWHAKIFYKKLMTASSQTNIMIPDVISGISLSLLFAATFIPIGFSFGFGTIILAHISSCTPYAIMIIYPRMLKMKKNLILASYDLGYTKIATFFRIILPYLLPSIISATIIVFAMSFDDFIITKLVGGKVNTIGTEMYSMAKGIKAWAVCFGALMVLLTILIAALISANKIIKLKLINKQTNKRKLKIWNRQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-07" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR42</accession>
    <name>UVRA_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein A</fullName>
            <shortName evidence="1">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrA</name>
        <name type="ordered locus">UU102</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688528.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR42"/>
    <dbReference type="SMR" id="Q9PR42"/>
    <dbReference type="STRING" id="273119.UU102"/>
    <dbReference type="PRIDE" id="Q9PR42"/>
    <dbReference type="EnsemblBacteria" id="AAF30508">
        <property type="protein sequence ID" value="AAF30508"/>
        <property type="gene ID" value="UU102"/>
    </dbReference>
    <dbReference type="GeneID" id="29672710"/>
    <dbReference type="KEGG" id="uur:UU102"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_14"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000093110" description="UvrABC system protein A">
        <location>
            <begin position="1"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="309"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="608"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="739"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="640"/>
            <end position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <sequence length="943" mass="105226" checksum="247C65AF094420A4" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR44</accession>
    <name>Q9PR44_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hsdM-2</name>
        <name evidence="4" type="ordered locus">UU100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891677.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU100"/>
    <dbReference type="REBASE" id="4891">
        <property type="entry name" value="M.UurORF100P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAF30506">
        <property type="protein sequence ID" value="AAF30506"/>
        <property type="gene ID" value="UU100"/>
    </dbReference>
    <dbReference type="GeneID" id="29672746"/>
    <dbReference type="KEGG" id="uur:UU100"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.106"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013049_2_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HsdM_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="187" mass="21964" checksum="2F568DE180E84CCE" modified="2000-10-01" version="1">MDNKKEIERNNLHATIWKIADELRGAIDGWDFKQYVLGILFYRYISENLTKYINDNEHKIGDHDFNYETCNDDDVDEEMKITLIKEKGFYIKPSFLFANIVKNAEKNENLNETLETVFNNIEGSSSGYDSEKNLKGLFNDIDVNNSRLGSTTQERNKRLARILIRIIYKNMDLLILKPYINKKEIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR50</accession>
    <name>Q9PR50_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689039.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU094"/>
    <dbReference type="EnsemblBacteria" id="AAF30500">
        <property type="protein sequence ID" value="AAF30500"/>
        <property type="gene ID" value="UU094"/>
    </dbReference>
    <dbReference type="GeneID" id="29672260"/>
    <dbReference type="KEGG" id="uur:UU094"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.98"/>
    <dbReference type="HOGENOM" id="CLU_293001_0_0_14"/>
    <dbReference type="OMA" id="EFYFAND"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004332344" evidence="1">
        <location>
            <begin position="33"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="1054" mass="122540" checksum="A3C90A0D2942A54C" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR51</accession>
    <name>Q9PR51_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcrA</name>
        <name evidence="5" type="ordered locus">UU093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688981.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU093"/>
    <dbReference type="EnsemblBacteria" id="AAF30499">
        <property type="protein sequence ID" value="AAF30499"/>
        <property type="gene ID" value="UU093"/>
    </dbReference>
    <dbReference type="GeneID" id="29672156"/>
    <dbReference type="KEGG" id="uur:UU093"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.97"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_14"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAF30499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="236" mass="27184" checksum="442FB3473939ADF8" modified="2000-10-01" version="1">MNNEFILEVKNLTKIYKKSNQGVFDLSFNVKRGEIHAFIGENGSGKTTTIKSIINAYTNYKGSILIDGFDNKTPKSHEKIGYVPEIALFPSELTTFQYLYSFARLSNLNKKQAIERIHNFLEKFRISDLKNKKPINFSSGQKKKVILIQALLHDPELIILDEPTANLDPSARHEFNNILKELHEQNKTIFICSHILKEMDTYVDSLTLIHKGKLVYSGHKYDALEKIYYDSVLKNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR57</accession>
    <name>Y088_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein UU088</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU088</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689002.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR57"/>
    <dbReference type="SMR" id="Q9PR57"/>
    <dbReference type="STRING" id="273119.UU088"/>
    <dbReference type="EnsemblBacteria" id="AAF30493">
        <property type="protein sequence ID" value="AAF30493"/>
        <property type="gene ID" value="UU088"/>
    </dbReference>
    <dbReference type="GeneID" id="29672728"/>
    <dbReference type="KEGG" id="uur:UU088"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_1_2_14"/>
    <dbReference type="OMA" id="NMNINEM"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000170460" description="Nucleoid-associated protein UU088">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <sequence length="99" mass="11369" checksum="525C51A1935A51F9" modified="2000-10-01" version="1">MDFQKLAQELKKMQNTLSKKQKEFEEKVFDFDYKGYVLVKIKGDLNIEAIEIKTEIVDPEDKETLQDILRAAINEAISITCKERDAIMNATIPKGTGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR59</accession>
    <name>Q9PR59_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxyguanosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dgk</name>
        <name evidence="4" type="ordered locus">UU086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688655.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU086"/>
    <dbReference type="EnsemblBacteria" id="AAF30491">
        <property type="protein sequence ID" value="AAF30491"/>
        <property type="gene ID" value="UU086"/>
    </dbReference>
    <dbReference type="GeneID" id="29672203"/>
    <dbReference type="KEGG" id="uur:UU086"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.89"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110684_0_0_14"/>
    <dbReference type="OMA" id="FAIFLDI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="3">
        <location>
            <begin position="22"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="26"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="161"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="232" mass="27339" checksum="B76F097F251EE0E1" modified="2000-10-01" version="1">MSDKKLDFLTPSFKKNRVSNSIAIGGMIAFGKSTLAQALHEKYQPSNVVYEMVEGDKLMDLLLAKMYERENNVLFGSLFQLYFVLNRFANYKNNCNRKSLTIFDRSIFEDWLFAHANIDKPSVFSYYDGLWQGVCKELIYEHGVPKLYVILDGDWELFKERIFKRNRKVEIDNFSINETYFKRLLEMYKNYMVNVCKDFGINYVVLDANNSVEQNVDEVTKILQKLENEQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR65</accession>
    <name>Q9PR65_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688669.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU080"/>
    <dbReference type="EnsemblBacteria" id="AAF30485">
        <property type="protein sequence ID" value="AAF30485"/>
        <property type="gene ID" value="UU080"/>
    </dbReference>
    <dbReference type="GeneID" id="29672743"/>
    <dbReference type="KEGG" id="uur:UU080"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.82"/>
    <dbReference type="eggNOG" id="COG2501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127162_2_3_14"/>
    <dbReference type="OMA" id="DQFLKWA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014330">
        <property type="entry name" value="RNA-bd_S4-rel_YaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02988">
        <property type="entry name" value="YaaA_near_RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="72" mass="8562" checksum="5DFD611B9A9554B7" modified="2000-10-01" version="1">MKKIFISTEYVTLNQFLKIAGLINNGGQAKFWLLENKVMVDEKIENRRGRKLYDQMIIKIKNQLYQIVKTNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR71</accession>
    <name>TRXB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Thioredoxin reductase</fullName>
            <shortName>TRXR</shortName>
            <ecNumber>1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">trxB</name>
        <name type="ordered locus">UU074</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688550.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PR71"/>
    <dbReference type="SMR" id="Q9PR71"/>
    <dbReference type="STRING" id="273119.UU074"/>
    <dbReference type="EnsemblBacteria" id="AAF30479">
        <property type="protein sequence ID" value="AAF30479"/>
        <property type="gene ID" value="UU074"/>
    </dbReference>
    <dbReference type="GeneID" id="29672186"/>
    <dbReference type="KEGG" id="uur:UU074"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_14"/>
    <dbReference type="OMA" id="FRAEDYW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000166755" description="Thioredoxin reductase">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0A9P4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="34150" checksum="CC01383CD53CB8A4" modified="2000-10-01" version="1">MNQEVYDLVIIGAGPAGLAAAVYAKRSGLNVIIVEKQFPGGKIALTSNVENYLGINSIPGPELAYKMYEQVLNLNVSIIYEAADEISLKEKYKKIKLTTQTLITKTVIIATGTENRRLNILGELEFENKGISYCAICDGPLYKNKAVSVIGSGNSAVEEAIYLATIAKEVHLIANKPQFKAEQQLVQIANNTPNIKIYYNKQTFEFFGHQFLEGLKFRDLITNEVTTLNIEANFTFIGLLPSRINTNNLCIFNEVNGFITTDKNMQTSVCGIFAAGDIVDKNVRQIATATNDGVIAALYAKEYITRNNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR74</accession>
    <name>Q9PR74_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ABC substrate-binding protein-iron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ABCsbp-4</name>
        <name evidence="1" type="ordered locus">UU071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688707.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU071"/>
    <dbReference type="EnsemblBacteria" id="AAF30476">
        <property type="protein sequence ID" value="AAF30476"/>
        <property type="gene ID" value="UU071"/>
    </dbReference>
    <dbReference type="GeneID" id="29672741"/>
    <dbReference type="KEGG" id="uur:UU071"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.73"/>
    <dbReference type="eggNOG" id="ENOG50341M9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_447470_0_0_14"/>
    <dbReference type="OMA" id="YVNIEDS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="655" mass="76241" checksum="A6A2533A92A62CB5" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PR92</accession>
    <name>Q9PR92_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP synthase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atpA-1</name>
        <name evidence="3" type="ordered locus">UU053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688732.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU053"/>
    <dbReference type="EnsemblBacteria" id="AAF30458">
        <property type="protein sequence ID" value="AAF30458"/>
        <property type="gene ID" value="UU053"/>
    </dbReference>
    <dbReference type="GeneID" id="29672321"/>
    <dbReference type="KEGG" id="uur:UU053"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.55"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_0_0_14"/>
    <dbReference type="OMA" id="QKALMFI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAF30458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="511" mass="57719" checksum="1EDF16B56DEAD009" modified="2000-10-01" version="1">MQNTKANPRIKSIFNYIVTVSGIYDYQHHQIFVLKNDPTVKLFVISAKEDLAYLLISNEHANINIGDEIIETNREENVVTDLNYFGKIIDINNNFIWPKPLNNLPSAKIAQTNPAFGLAHNLMTVKTLNEQLNTGIVAIDLLIPIGKGQRELIIGDRQTGKTHIALNTIINQSRAGTKCIYVAIGQKRESLTTVYETLKAHDALKNTIIIDAPLTAYEQYLAPYIGMAHAENLSYQDDVLIVFDDLTKHANIIREMALLTNKPVGKEAMPSDVFFSHSSLLERAGSFKNRKTITALPILQTVDGDITSLISSNIISITDGQIVTSTDLFAAGKVPAINIDLSVSRTGSSVQSRMITKVAGEINKIFRQYKRHLKLAMLDYEFNKETSLLLHKGKLIDKMFLQKGFSLFSYRFIVLSTKLIAWGILKGVKDEQKAFMLLDYAINNYEDAQKAFNTISTTQNYDDKIMKNYFAFILKQYSDYLNLNWEVELEHSFIPLQNEFLMNVAKFLGDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRA3</accession>
    <name>Y042_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU042</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU042</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">To U.parvum UU007, UU008 and UU041.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891664.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRA3"/>
    <dbReference type="SMR" id="Q9PRA3"/>
    <dbReference type="STRING" id="273119.UU042"/>
    <dbReference type="EnsemblBacteria" id="AAF30447">
        <property type="protein sequence ID" value="AAF30447"/>
        <property type="gene ID" value="UU042"/>
    </dbReference>
    <dbReference type="GeneID" id="29672168"/>
    <dbReference type="KEGG" id="uur:UU042"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.44"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153958_0_0_14"/>
    <dbReference type="OMA" id="MNESEYI"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220787" description="Uncharacterized protein UU042">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="138" mass="15547" checksum="4F365FC1D9E6CD97" modified="2000-10-01" version="1">MSPISIELIIQISIGLSASLILLFAFLPQTLLTIKTKNTAALTISMFIICFIARLCFSLSAILTIIVYIHNQNYGLSLYALTLPVLICHGINMLLNLIIAFIKINNVYKAKIHKMNENEYIIFAYAQKLKEKVSIKNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB1</accession>
    <name>Y034_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized ATP-binding protein UU034</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU034</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891657.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRB1"/>
    <dbReference type="STRING" id="273119.UU034"/>
    <dbReference type="EnsemblBacteria" id="AAF30439">
        <property type="protein sequence ID" value="AAF30439"/>
        <property type="gene ID" value="UU034"/>
    </dbReference>
    <dbReference type="GeneID" id="29672393"/>
    <dbReference type="KEGG" id="uur:UU034"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.36"/>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820540_0_0_14"/>
    <dbReference type="OMA" id="WIYTIES"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220784" description="Uncharacterized ATP-binding protein UU034">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="355" mass="40948" checksum="195E4E017FB02AE3" modified="2000-10-01" version="1">MLISKHEERVKSILSARMENGNLRSRENTQVEFKQSFNKGNIAIYAKTMAAFSNNSGGYIIFGIKDSPRSIIGLQNSNFENIQQEDLTDSINNLFSPSINWELGSFILKEKEINSNGDVIIVQKIIGWIYTEESNIKPVIAQKNNSSEKIVNGDIFYRYRARTEKIKYAEMEQIINCRMKQERDSLFKVFEFIRNNGATNLGIVDYNNGKLSTPYGVDVVLEKNLIAKLLKKAKFIKEGSFSENEGIPVIKVTGNINLAEEVPVPLENLDETYPYIQKQLAEKLNITPQKLYALIWYFKMKESKKYHLEITTSKTNKTHKFSKFALLFLKEKIIELDENKNELNNIISKFNNRKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB3</accession>
    <name>Y032_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU032</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU032</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891655.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRB3"/>
    <dbReference type="STRING" id="273119.UU032"/>
    <dbReference type="EnsemblBacteria" id="AAF30437">
        <property type="protein sequence ID" value="AAF30437"/>
        <property type="gene ID" value="UU032"/>
    </dbReference>
    <dbReference type="GeneID" id="29672560"/>
    <dbReference type="KEGG" id="uur:UU032"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.34"/>
    <dbReference type="eggNOG" id="ENOG5033699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1522492_0_0_14"/>
    <dbReference type="OMA" id="CYENWVK"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220783" description="Uncharacterized protein UU032">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="175" mass="20950" checksum="93FDAD28712E5222" modified="2000-10-01" version="1">MSKKINNNKTPRNKVKNNNVSKDNDDIVISLRYENWVKEERVNSLTTYTKDENQFLKNIIYILNTLFPYVYKNWKNKGINDHCHPIKQNNVFSKYIKLIKKLHPNLLKNDNEELELYQLGLGRSVRVICSKIDNILFPLLIDHHHLGYESQSYNDKDTKKYDYCPLRKYNKNQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB6</accession>
    <name>Q9PRB6_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">UU029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891652.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU029"/>
    <dbReference type="EnsemblBacteria" id="AAF30434">
        <property type="protein sequence ID" value="AAF30434"/>
        <property type="gene ID" value="UU029"/>
    </dbReference>
    <dbReference type="GeneID" id="29672157"/>
    <dbReference type="KEGG" id="uur:UU029"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.29"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_14"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="642"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="706" mass="80660" checksum="35E5BFE6A155CB66" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD3</accession>
    <name>Q9PRD3_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Unique hypothetical membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">UU012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688622.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU012"/>
    <dbReference type="EnsemblBacteria" id="AAF30417">
        <property type="protein sequence ID" value="AAF30417"/>
        <property type="gene ID" value="UU012"/>
    </dbReference>
    <dbReference type="GeneID" id="29672506"/>
    <dbReference type="KEGG" id="uur:UU012"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.12"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_526693_0_0_14"/>
    <dbReference type="OMA" id="MANDGKR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004330952" evidence="2">
        <location>
            <begin position="19"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="55"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="516" mass="56682" checksum="AC83BAE90D91B6E8" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD5</accession>
    <name>RL10_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rplJ</name>
        <name type="synonym">rpl10</name>
        <name type="ordered locus">UU010</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688636.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRD5"/>
    <dbReference type="SMR" id="Q9PRD5"/>
    <dbReference type="STRING" id="273119.UU010"/>
    <dbReference type="EnsemblBacteria" id="AAF30415">
        <property type="protein sequence ID" value="AAF30415"/>
        <property type="gene ID" value="UU010"/>
    </dbReference>
    <dbReference type="GeneID" id="29672245"/>
    <dbReference type="KEGG" id="uur:UU010"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_2_0_14"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000154742" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="166" mass="18220" checksum="428BCE7029A7DEF1" modified="2000-10-01" version="1">MANVRPSVVFKQQEVNHMADILKNSKSFIVFEYHGLTAANILALRNVLHSSNSKLYVLKNNITARAFEKAGVSGFENQLTGPNAVAVAMDDEIAAIKAVNDVAKEFDFVKIKGAYLENKFADTHKIDQLAAIPGREGLYSMLLSCFTAPLRNVMYGLKAVAEQKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRD9</accession>
    <name>Q9PRD9_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactoside O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lacA</name>
        <name evidence="4" type="ordered locus">UU006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688688.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU006"/>
    <dbReference type="EnsemblBacteria" id="AAF30411">
        <property type="protein sequence ID" value="AAF30411"/>
        <property type="gene ID" value="UU006"/>
    </dbReference>
    <dbReference type="GeneID" id="29672238"/>
    <dbReference type="KEGG" id="uur:UU006"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.6"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_14"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="154" mass="17055" checksum="858C86164FB45342" modified="2000-10-01" version="1">MIKKIYFGNDHAAYEIKDQIITHLKQKGYQIIDEGAQAALGSVDYSTYALKVANDVVNDTKNDSIGILLCGTGIGMNIAASKVHGTRVALVYNESSAKLAKEHNNANIITIGARENSLNQILKMIDDFLTSKFLGERHQKRLDIIAKYEKEQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PPX2</accession>
    <name>Q9PPX2_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC substrate-binding protein-iron</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ABCsbp-8</name>
        <name evidence="4" type="ordered locus">UU517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688615.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU517"/>
    <dbReference type="EnsemblBacteria" id="AAF30930">
        <property type="protein sequence ID" value="AAF30930"/>
        <property type="gene ID" value="UU517"/>
    </dbReference>
    <dbReference type="GeneID" id="29672301"/>
    <dbReference type="KEGG" id="uur:UU517"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.537"/>
    <dbReference type="HOGENOM" id="CLU_508002_0_0_14"/>
    <dbReference type="OMA" id="TISHHQR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022382">
        <property type="entry name" value="Mycoplasma_peptidase_DUF31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022381">
        <property type="entry name" value="Uncharacterised_MG067"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01732">
        <property type="entry name" value="DUF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00840">
        <property type="entry name" value="Y06768FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="DUF31" evidence="3">
        <location>
            <begin position="59"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAF30930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="536" mass="61789" checksum="093D1ADA4D928EFA" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ20</accession>
    <name>Q9PQ20_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pfs</name>
        <name evidence="2" type="ordered locus">UU470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891787.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU470"/>
    <dbReference type="EnsemblBacteria" id="AAF30882">
        <property type="protein sequence ID" value="AAF30882"/>
        <property type="gene ID" value="UU470"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU470"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.486"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2072129_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAF30882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="118" mass="13408" checksum="03FEAA597B7266E8" modified="2000-10-01" version="1">MIGLIVALNSEIKTFFKQIKKKVYQINNIDFYLCTHQNIEFVLVFTDVGKTNASFITALLINNFKPKVILNVGSCGALNDQLQVLDIAIIDQCQYLDVNVSAFGYLKNQIPRLDNFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2020-08-12" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ46</accession>
    <name>Q9PQ46_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU444"/>
    <dbReference type="EnsemblBacteria" id="AAF30856">
        <property type="protein sequence ID" value="AAF30856"/>
        <property type="gene ID" value="UU444"/>
    </dbReference>
    <dbReference type="KEGG" id="uur:UU444"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2977997_0_0_14"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="58" mass="6714" checksum="CC97E9E6CB185A06" modified="2000-10-01" version="1">MKNQKDFYFYGASSNAVLNKKVNFDLLKNTSINKTLEQLVANKVKFIIDIKHLLDLLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQ82</accession>
    <name>DNAJ_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaJ</name>
        <name type="ordered locus">UU407</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006689084.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQ82"/>
    <dbReference type="SMR" id="Q9PQ82"/>
    <dbReference type="STRING" id="273119.UU407"/>
    <dbReference type="PRIDE" id="Q9PQ82"/>
    <dbReference type="EnsemblBacteria" id="AAF30818">
        <property type="protein sequence ID" value="AAF30818"/>
        <property type="gene ID" value="UU407"/>
    </dbReference>
    <dbReference type="GeneID" id="29672368"/>
    <dbReference type="KEGG" id="uur:UU407"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_14"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000070926" description="Chaperone protein DnaJ">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="5"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="148"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="1">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <sequence length="375" mass="41841" checksum="E339AFA9770331FC" modified="2000-10-01" version="1">MAKRDYYEILGVSKSATPEEIKAAFRKLAKEHHPDRNKSADDTLFKEINEAYEVLSDSKKRAQYDQFGHDGPQGFSSASGFSGFSGGFGGVDFDINDIFGSFFNNASSSHNSSNQYETYDIHLRLHLDFMEAVNGISKNINYDRKITCHKCQGTGAKDPKDVKICTKCHGRGTSIENVHSLFGTIQQEVECHECEGTGKVASSKCEQCYGKKVINERVNLTVEIPAGTREGEKLLVSKKGNIVNNQEFDLYLHISVKPSKYFALDGLDIYSETYIDPIKAIVGGIIEVVTINGIKTIEIPSNTPEGKKFRISGSGIVNKKSNIFGKKNGDFYTTIRYAKPVELSKDEIAYLKNISTRTNQNVEYYKNKVLKEISK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQE5</accession>
    <name>SCPB_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Segregation and condensation protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">scpB</name>
        <name type="ordered locus">UU346</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ScpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Differs from other ScpB proteins because it has a much longer N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688488.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQE5"/>
    <dbReference type="SMR" id="Q9PQE5"/>
    <dbReference type="STRING" id="273119.UU346"/>
    <dbReference type="EnsemblBacteria" id="AAF30755">
        <property type="protein sequence ID" value="AAF30755"/>
        <property type="gene ID" value="UU346"/>
    </dbReference>
    <dbReference type="GeneID" id="29672429"/>
    <dbReference type="KEGG" id="uur:UU346"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760629_0_0_14"/>
    <dbReference type="OMA" id="HAMIRRR"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211166" description="Segregation and condensation protein B">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="364" mass="42001" checksum="E0BAA51FEA5CC141" modified="2000-10-01" version="1">MNNDKKNKKNLLNNELDLAKYTLHNLSADNNDDENELELDWDGIDDEIIDNNQQIYQKKHINHKTRLFIEKDDKLNNHEQIESGNEIINQPKALSGQDFLEFVNSKLVQKNNNFKQNSKFLQNQLTNHELLREKLKPQEDFNKIFKTKDINVTEEIKIKDVKKNSSVSFRNSFNINDLNQNQITNIKSIIDSTLFLAGEEGVSLQDLKRTTGLNESSQLKTILNQLQKDYDVDDSGLVLVQFGEKFKLLTQSKNKDALSKFVTTSFRTPLSQRNLETLAIIAYNQPTTRAKIQAIRDRDPKPAIDALLKLNLIIEAGRQDTPGHPILYTVSQKFYDLFGIRNLTELPRLNKEINEFSPIDESTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-10-01" modified="2021-06-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQH5</accession>
    <name>Q9PQH5_UREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Unique hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">UU316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ATCC 700970</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688533.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="STRING" id="273119.UU316"/>
    <dbReference type="EnsemblBacteria" id="AAF30725">
        <property type="protein sequence ID" value="AAF30725"/>
        <property type="gene ID" value="UU316"/>
    </dbReference>
    <dbReference type="GeneID" id="29672365"/>
    <dbReference type="KEGG" id="uur:UU316"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.329"/>
    <dbReference type="HOGENOM" id="CLU_1980652_0_0_14"/>
    <dbReference type="OMA" id="YNWNTIS"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAF30725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000423"/>
        </source>
    </evidence>
    <sequence length="126" mass="15291" checksum="589232239D62B150" modified="2000-10-01" version="1">MKNFSKNRNINNFKNPLRVIEGIVREIKNNELQIDFVNSHKKGVCKFINLTDYHWNTISSRFLINSKHLFLVSKFDPIRHVYWLNYKIIHPIEIKNKRRSYPTLSHDRNLRIFLNNLLEKENELKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-02-11" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQP7</accession>
    <name>RS14Z_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsZ</name>
        <name evidence="1" type="synonym">rps14</name>
        <name evidence="1" type="synonym">rpsN</name>
        <name type="ordered locus">UU244</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004026507.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQP7"/>
    <dbReference type="SMR" id="Q9PQP7"/>
    <dbReference type="STRING" id="273119.UU244"/>
    <dbReference type="EnsemblBacteria" id="AAF30653">
        <property type="protein sequence ID" value="AAF30653"/>
        <property type="gene ID" value="UU244"/>
    </dbReference>
    <dbReference type="GeneID" id="45015788"/>
    <dbReference type="KEGG" id="uur:UU244"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_14"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000130958" description="30S ribosomal protein S14 type Z">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <sequence length="61" mass="6993" checksum="EF175B6BD2056887" modified="2000-10-01" version="1">MAKKSLIAKQKKHQKFAVREYTRCVRCGRPHAVNRKFGVCRLCFRDLAYAGAIPGIKKASW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-01-23" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQR3</accession>
    <name>RL35_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name evidence="1" type="synonym">rpl35</name>
        <name type="ordered locus">UU228</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688895.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQR3"/>
    <dbReference type="SMR" id="Q9PQR3"/>
    <dbReference type="STRING" id="273119.UU228"/>
    <dbReference type="EnsemblBacteria" id="AAF30637">
        <property type="protein sequence ID" value="AAF30637"/>
        <property type="gene ID" value="UU228"/>
    </dbReference>
    <dbReference type="GeneID" id="29672671"/>
    <dbReference type="KEGG" id="uur:UU228"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_3_0_14"/>
    <dbReference type="OMA" id="GHAYKNH"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000177450" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <sequence length="64" mass="7471" checksum="64828066737120B7" modified="2000-10-01" version="1">MAKIRQKTKRAVAKRFSITKNGKLKRKHAYRSHLALGRSTKAKRHLRKDAIMSTSDTKRYTQCL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-11-08" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQU6</accession>
    <name>SYM_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="1">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metG</name>
        <name type="synonym">metS</name>
        <name type="ordered locus">UU197</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688946.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQU6"/>
    <dbReference type="SMR" id="Q9PQU6"/>
    <dbReference type="STRING" id="273119.UU197"/>
    <dbReference type="EnsemblBacteria" id="AAF30604">
        <property type="protein sequence ID" value="AAF30604"/>
        <property type="gene ID" value="UU197"/>
    </dbReference>
    <dbReference type="GeneID" id="29672640"/>
    <dbReference type="KEGG" id="uur:UU197"/>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_4_14"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000139261" description="Methionine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <sequence length="521" mass="60831" checksum="F9CD1A428B132DC5" modified="2000-10-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-01-10" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PQW1</accession>
    <name>GPMI_UREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-independent PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">iPGM</shortName>
            <ecNumber evidence="1">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmI</name>
        <name type="synonym">pgm</name>
        <name type="ordered locus">UU182</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="1"/>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006688824.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PQW1"/>
    <dbReference type="SMR" id="Q9PQW1"/>
    <dbReference type="STRING" id="273119.UU182"/>
    <dbReference type="EnsemblBacteria" id="AAF30589">
        <property type="protein sequence ID" value="AAF30589"/>
        <property type="gene ID" value="UU182"/>
    </dbReference>
    <dbReference type="GeneID" id="29672642"/>
    <dbReference type="KEGG" id="uur:UU182"/>
    <dbReference type="eggNOG" id="COG0696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_14"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000212225" description="2,3-bisphosphoglycerate-independent phosphoglycerate mutase">
        <location>
            <begin position="1"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
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        </location>
    </feature>
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        <location>
            <position position="13"/>
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
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        <ligand>
            <name>substrate</name>
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            <begin position="146"/>
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        <ligand>
            <name>substrate</name>
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            <name>substrate</name>
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    <feature type="binding site" evidence="1">
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            <begin position="251"/>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <ligand>
            <name>Mn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
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            <position position="393"/>
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            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
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            <position position="430"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
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            <position position="431"/>
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            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <sequence length="502" mass="57393" checksum="CBC67422051F28D9" modified="2000-10-01" version="1">MKLNKKIGLIIIDGLGIGKEDNTNAVHLANPPTLNYLINNFPTLQISAAQQNIGLLENQAGNSEIGHLTIGAGRIILNDNANINNYMKSVDYESAVLSNIKNEIVHIVGMYSNGLVHSNYEHIHWIIKQIIKNNNQVVLHLISDGRDDYPYGFAQFIEQINALKKQYNIIVKSLSGRYFAMDRDQRWERTQKAFNAMFVKQDKICEKTFLEVAQSIANSYKSDEFVQPVVFNDDEKYNLKPHQKVILANYRSDRMRQLAHLLKPNKKFHYNNPFLVQDVNLITLVPFPDVDAIALFEKQNLNNTLGDVFNKHQIKEARIAETEKYAHISFFFDGGVNKYYSTKTQYLIPSQKVATYDLCPQMSAHLITKTIIDHYFDHDVFIVNYANPDMVGHSGNMQQTIEAILSVDHEIRKLYDFFEKNNGVLMITGDHGNAEMMLDDQKQVITSHSVNDVWFIITDNKVILNSTQKFSLANIAPTILEYLNIAQPIQMTATSMIKKICE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9PRB5</accession>
    <name>Y030_UREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein UU030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">UU030</name>
    </gene>
    <organism>
        <name type="scientific">Ureaplasma parvum serovar 3 (strain ATCC 700970)</name>
        <dbReference type="NCBI Taxonomy" id="273119"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Tenericutes</taxon>
            <taxon>Mollicutes</taxon>
            <taxon>Mycoplasmataceae</taxon>
            <taxon>Ureaplasma</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Nature" volume="407" first="757" last="762">
            <title>The complete sequence of the mucosal pathogen Ureaplasma urealyticum.</title>
            <authorList>
                <person name="Glass J.I."/>
                <person name="Lefkowitz E.J."/>
                <person name="Glass J.S."/>
                <person name="Heiner C.R."/>
                <person name="Chen E.Y."/>
                <person name="Cassell G.H."/>
            </authorList>
            <dbReference type="PubMed" id="11048724"/>
            <dbReference type="DOI" id="10.1038/35037619"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 700970</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AF222894">
        <property type="protein sequence ID" value="AAF30435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010891653.1">
        <property type="nucleotide sequence ID" value="NC_002162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PRB5"/>
    <dbReference type="STRING" id="273119.UU030"/>
    <dbReference type="EnsemblBacteria" id="AAF30435">
        <property type="protein sequence ID" value="AAF30435"/>
        <property type="gene ID" value="UU030"/>
    </dbReference>
    <dbReference type="GeneID" id="29672753"/>
    <dbReference type="KEGG" id="uur:UU030"/>
    <dbReference type="PATRIC" id="fig|273119.6.peg.30"/>
    <dbReference type="eggNOG" id="ENOG5033T8T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372116_0_0_14"/>
    <dbReference type="OMA" id="NSHHENW"/>
    <dbReference type="Proteomes" id="UP000000423">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022382">
        <property type="entry name" value="Mycoplasma_peptidase_DUF31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01732">
        <property type="entry name" value="DUF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000220782" description="Uncharacterized protein UU030">
        <location>
            <begin position="1"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="747" mass="85861" checksum="68FFD940C28D02AF" modified="2000-10-01" version="1"> </sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>