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<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
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    <name>A0A133V925_9EURY</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">AKJ48_04370</name>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="LHYB01000096">
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    </dbReference>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
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            <position position="1"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KXB02970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="190" mass="19419" checksum="3679076823D2D6A5" modified="2016-07-06" version="1" fragment="single">GKIPKKQILGTMDVKIVPSEISQSPLIGILSAGNKSGLVVPDLIESGEKELEEKLSIRVARVPGKYTALGNQVLANDNGAIVSPNLPDKAVKIVEKTLNVQAERGTIAGLKSVGSAGVATNKGVLLHPDASKEELGKVEEALGVQGDIGTALGGVKYVGACMVANSLGVLTGESTTGPELGRIESSLGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9J7</accession>
    <name>A0A133V9J7_9EURY</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000088">
        <property type="protein sequence ID" value="KXB03085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03085">
        <property type="protein sequence ID" value="KXB03085"/>
        <property type="gene ID" value="AKJ48_04235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="60" mass="7120" checksum="1E7984161B8A3E6A" modified="2016-07-06" version="1" fragment="single">PRWYEKTALPLLTGIKPGELKEHTLLRALDYLQEEQTRDIQREIYQSIKQKFGIETGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9P9</accession>
    <name>A0A133V9P9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_04210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000086">
        <property type="protein sequence ID" value="KXB03117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03117">
        <property type="protein sequence ID" value="KXB03117"/>
        <property type="gene ID" value="AKJ48_04210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="11"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB03117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="321" mass="36561" checksum="599EFADCA51CEAB2" modified="2016-07-06" version="1">MNRELRGSKIEDYDAPLFIAWQLTSECNLKCKHCLEESGPGHSRLWDEMEGKELFDFCDQIVENDIPYVAISGGEPMLHTKFFDICEYIRSAGLSLKVETNGHFIDEEEARKFAKLGLRSVQVSLDGATPETYEKMRPNGNFEKTVKACELLSSEGVNTEIVFVPAKFNLQEAEDVIDLAASLGASGFYTGKTMKIGRATENWDEINISDEEYDGFFKILDEKSKEYDGQMKVYYYPLDILEELKYRLDSPAASLLIKPNGDVKLIGPLPFTVGNVKRQDLQEVWENYKRAWRDPKVIEHTRKVIENPNLLAGPTDSVELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9R7</accession>
    <name>A0A133V9R7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000085">
        <property type="protein sequence ID" value="KXB03137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03137">
        <property type="protein sequence ID" value="KXB03137"/>
        <property type="gene ID" value="AKJ48_04200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="66" mass="7134" checksum="6D824C9A6874D9CE" modified="2016-07-06" version="1">MDASSKEFDNITLPYGEEGAPSFPSIPLPLAIAAAVIFLVGVGVYFIKGGKSREEPYPYEPQSEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA06</accession>
    <name>A0A133VA06_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000077">
        <property type="protein sequence ID" value="KXB03271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03271">
        <property type="protein sequence ID" value="KXB03271"/>
        <property type="gene ID" value="AKJ48_04045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="113" mass="12807" checksum="5C118BD077AF17F4" modified="2016-07-06" version="1">MVEEKLEKSLSEFLENGDDWERKPTSVRGVFVLKLPKYKGSPPRLAAEVNPVDSRGNPTKKRGLLIRNPVELKKFRDLIKEEGLDGLLNAVDEVNPGPSKEVRPEEEEEVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA36</accession>
    <name>A0A133VA36_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AA_TRNA_LIGASE_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000076">
        <property type="protein sequence ID" value="KXB03296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03296">
        <property type="protein sequence ID" value="KXB03296"/>
        <property type="gene ID" value="AKJ48_04040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.827"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005246">
        <property type="entry name" value="O-Pseryl-tRNA(Cys)_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041590">
        <property type="entry name" value="SepRS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF38">
        <property type="entry name" value="PTHR11538:SF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18006">
        <property type="entry name" value="SepRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00470">
        <property type="entry name" value="sepS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="1">
        <location>
            <begin position="66"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="468" mass="53503" checksum="D6A5D5F62FEF2F66" modified="2016-07-06" version="1" fragment="single">LGFREIVVPTLIEEDEIYKQYGPQAPVILDRIFFLANLERPDIGISDEKIDQIKDIIQGFDSPDELKTIFKKYKLGKINSDDLPEVLMTELGIEEYQATALLSLFEEFRELKPVPTSLTLRSHTTAGWFSVLQQIQQREDLPIQLFAVGPKYRREQKLDKTHLYESWTASLVIMTEEMSLEDGKRLTEKIMDKLEFKKVNCKIKRATSKYYAPKTEFEVYVKHPETGEMIEVGDAGFYSPVALARYDISNPVFNLGIGLERVLMIREGVEDIRELIYPYQYQEIEPTDEEIARMLEIKKEPKTKAGEKIAKKVKKTAESHKDEPSPCEFEAFEGEVNDAKVRVRVIETEEDKKLVGPAGFNEIYVYDGNIVGVPPEGWEEYKFLKKARDNGINTGITYMDAFAALAASRIEEAIQKGEKKVKVRVPIVKSLGDLNLKLGKSARRYITNNKKRIDIRGPVFTTVLAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA59</accession>
    <name>A0A133VA59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000075">
        <property type="protein sequence ID" value="KXB03314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03314">
        <property type="protein sequence ID" value="KXB03314"/>
        <property type="gene ID" value="AKJ48_04020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="78" mass="8852" checksum="B0607037F32D946B" modified="2016-07-06" version="1">MSKKVDFTLLTSAGLLELLLESAKEKGKKARLTEKLNDSFVISIGRKTTEFTLTNDIWVNYELSKPSLESLFQRSVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA97</accession>
    <name>A0A133VA97_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000073">
        <property type="protein sequence ID" value="KXB03359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03359">
        <property type="protein sequence ID" value="KXB03359"/>
        <property type="gene ID" value="AKJ48_03960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="190" mass="21919" checksum="558183BCC737F897" modified="2016-07-06" version="1">MPLIEDGRLARIFFHIAGDGYAGKFGGSHPHYFNTNRAVVNEFVNDLSTFGIVNVRFQENRARVTFPKVIVHVLKHLYKTSFLSREIRIPQELSSVRRQVIAQGIKALADDEASVCRNRIRIHSSNKRFLEDIFDLMTQKFPSLAEYVSINSTRNNEHYLTIRKNGMKLSSEIIGFTHTQKKKRLDSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAD4</accession>
    <name>A0A133VAD4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000071">
        <property type="protein sequence ID" value="KXB03404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03404">
        <property type="protein sequence ID" value="KXB03404"/>
        <property type="gene ID" value="AKJ48_03910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="143" mass="16126" checksum="5C94868E9BC871F4" modified="2016-07-06" version="1">MEGQEKIVLDASVVVKWFSQEEGSDLALEVKNQYVEGELIILSADLLIYEVSNALMFNPDFDQEDVANAVKDIFDLDLDLITPIEEILIRATEYASENNLTIYDSCYISLAEMMGIPLYTADGKLLENTEDLDFVKSLKYLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAK5</accession>
    <name>A0A133VAK5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable GTP 3',8-cyclase</fullName>
            <ecNumber evidence="11">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">moaA</name>
        <name evidence="13" type="ORF">AKJ48_03885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="11"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="AKJ48_03885"/>
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    <dbReference type="UniPathway" id="UPA00344"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <keyword evidence="6 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
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            <end position="230"/>
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        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
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        <location>
            <position position="24"/>
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    </feature>
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        <location>
            <position position="26"/>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
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        <location>
            <position position="60"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="302" mass="33985" checksum="E0E2711FE0EEB1B0" modified="2016-07-06" version="1">MKDNYGRPVTSIRISVTNDCDLDCFYCHREGCLEGNREMAPSEIGEIVRIGTEFGIEKVKLTGGEPLMSPDIIEIVSAVNQPPINDVSLTTNGTTLAEKSGELKEAGLDRINISLDTLNPEVYEEITGEPKLNQVLDGIDAALDAGLWPVKLNMIVLNGVNNEEIEQIMEYSLDHGTILQIIELLWTQDTADIYKKYHASLDSIEEKLKERAGGVKTRWLMQARRKYLINGGEVEIVNPMHNSEFCAHCTRIRMTPDGYLKPCLMRNDNLVDILTPIRAGDEKKVRDAFREAISRREPYYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAZ9</accession>
    <name>A0A133VAZ9_9EURY</name>
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        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03755</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
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                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="AKJ48_03755"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
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            <end position="87"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="96" mass="11178" checksum="5C5879A461AA9A30" modified="2016-07-06" version="1">MDFDRLVHQPTRLRILSRLYTQGEASFTELGENLDLTEGNLSSHLRKLEDAGYVQVEKAFEDRKPKTTYRLTREGEDALEDHVKRLEKIIDSLESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB04</accession>
    <name>A0A133VB04_9EURY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
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                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
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                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000064">
        <property type="protein sequence ID" value="KXB03584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03584">
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        <property type="gene ID" value="AKJ48_03760"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="209" mass="23295" checksum="53A6298889B45AD9" modified="2016-07-06" version="1">MSDEINKEALREEVSHIKEAMGIQERYPSQAKSWILWGSLFAAACFLSQIVAIKQWPGYLYIVIWWVLMGAVGGPLQAKISKEHEGEIVETGTKPSFWVSIVAVLAAAFVIVISTSPFIGDLGYYETTAYIGTTILALVGVYYVILGNQLKAYYIRKSDRYALYIAGAWLLALSAVIPHFQILTNWMYAIYGVTFAAYSLGAYRILSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB99</accession>
    <name>A0A133VB99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000060">
        <property type="protein sequence ID" value="KXB03731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03731">
        <property type="protein sequence ID" value="KXB03731"/>
        <property type="gene ID" value="AKJ48_03670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="200" mass="22604" checksum="B9530DDE951D3496" modified="2016-07-06" version="1">MLELVVTPCVLTLPQALGLVESQNLYNAIILNRNMIVFDASTLILLAKIQLLRTIASETKISIPPIIKEEVTRKETTDAKLIEQLIEEGRIKVIDIRAMEEVKKLKEDFSIEEEAHAILLARERESTLATDDGQAIKVCKIFGLKFTTAIDFLIRAHERGHLSKTIALEKLRKLEEYGYYRSLIIEFARNKIGGGANEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBK4</accession>
    <name>A0A133VBK4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ORF">AKJ48_03645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000059">
        <property type="protein sequence ID" value="KXB03774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03774">
        <property type="protein sequence ID" value="KXB03774"/>
        <property type="gene ID" value="AKJ48_03645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.699"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB03774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="475" mass="54500" checksum="26D942C6448C362A" modified="2016-07-06" version="1">MKREKWESDFNSWFNDVLSDAEIMDIRYPVKGLYVWMPYGIKLRNHVIGIIRQLLENTGHQEVLFPLLIPRDVFEKEAEHIKGFEDEVYWVTKGGTSKLNVDLALRPTSETSIYPMLKLWIRSHTDLPLKVYQVVNIFRHETKATKPLIRLREVTTFKEAHTAHESEEDAEEQIKKAVEIYKEFFDELGVSYVITKRPAWDTFAGAKYSIAFDMLAPNGRTLQIGTVHNLGQGFSKVFDLTYETPDGDQEHIYQTCYGISDRVIASVLIAHGDDRGPCLPPNVAPIQVVIVPVPFKEEKVDVNKEAEKVQDELEDAGIRAKVDDRDLRPGDKYYRWERRGVPVRIEIGPQELKEEKITIVRRDTGEKLSKPRGSLIEDTNEIFKEIKNDLKERAKSYLEDKIEWAEDLEKARDIIENKQGIARVSWCGQKDCGQKIEDETGGDILGPEFEGETKTGKCIVCGKKTKTPAIVARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBN6</accession>
    <name>A0A133VBN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000057">
        <property type="protein sequence ID" value="KXB03872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03872">
        <property type="protein sequence ID" value="KXB03872"/>
        <property type="gene ID" value="AKJ48_03600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="401" mass="43882" checksum="527A7E37A25059B5" modified="2016-07-06" version="1">MMIVVGLESCVDVWVTFPNLNGFEGFAREYDGPLTSHVKDAYSAVREGVGGEVPIDGKANEARELIEAASDRGAKVKQALGGNGAQETAAFKALGSDVAFIGGFSPSQVTQLPSKSREFFEGADLSFAYSSGEYRPISVILQARGTNRYILCEGQGRRIEQLRPYVRKLSEVIGRVLDRYGKPDMMNLVGWHVLFANGISDRDLRLVKKVIREIRGVVDSPLFTDAGGLGAFGEGEKHRLCQIYSLFDILSVNEDEVMEVSRTLGSEAEDEFRAMHDILESSEKPSTIWLHSTDYQASLSTQYGRELLERAQTAAATAGVHRVENGAYPTLEELRGWVRVENYSEEGLKVVERAEREYGSKIGSAELVVTPCYKARSFKSTVGAGDTAAAAYAYVIAGGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBS8</accession>
    <name>A0A133VBS8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000057">
        <property type="protein sequence ID" value="KXB03875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03875">
        <property type="protein sequence ID" value="KXB03875"/>
        <property type="gene ID" value="AKJ48_03615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="59" mass="6868" checksum="5C9FC260AB5B5A87" modified="2016-07-06" version="1">MMKKYYKEDDYEDLFLESKEDLQKQAPAKIIVVKNDAEGLDKLEEELGKVIDVMEEANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBU7</accession>
    <name>A0A133VBU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000056">
        <property type="protein sequence ID" value="KXB03926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03926">
        <property type="protein sequence ID" value="KXB03926"/>
        <property type="gene ID" value="AKJ48_03570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.681"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="109"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="265" mass="28226" checksum="FD14923602D264D3" modified="2016-07-06" version="1">MTARIFQKISELIAEDQTFAVATIVRVDGSSPRGPGAKMIILEDGTTFGTVGGDCAERAVVDEALKVLERGEPKTLSIPLEEEEKGGVGMKCGGEIEVSIEVVHPSPELVITGAGKIATSVAELAEEMGFSITVVDPFVKTGDFPDSVKIIDEPVEQGLSNVEITSNTYVVIITRHKDDIPALKAVLNKGAAYIGLMGSKSRVKAQFEELVKEGFSKEELSQVHAPIGLDIGAETPEEIAVSILAEVIKQRRKPESSGESLKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBX2</accession>
    <name>A0A133VBX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000055">
        <property type="protein sequence ID" value="KXB03952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03952">
        <property type="protein sequence ID" value="KXB03952"/>
        <property type="gene ID" value="AKJ48_03545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="59" mass="6852" checksum="D1FD0A026F533128" modified="2016-07-06" version="1">MGFRVKKTGTFLAKISINLFGVLGSKTLDHSRDDYRSLDDSTILNMKSNLNEVRYLRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC35</accession>
    <name>A0A133VC35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000055">
        <property type="protein sequence ID" value="KXB03954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03954">
        <property type="protein sequence ID" value="KXB03954"/>
        <property type="gene ID" value="AKJ48_03555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="60" mass="6969" checksum="A901829704691F2A" modified="2016-07-06" version="1">MPSEKKTDEKRAYGGDFAISGEEEELAISRKKRKRLQSKKKGLRKLTEGRNQGKYQNIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC61</accession>
    <name>A0A133VC61_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000053">
        <property type="protein sequence ID" value="KXB04007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04007">
        <property type="protein sequence ID" value="KXB04007"/>
        <property type="gene ID" value="AKJ48_03485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="123" mass="13564" checksum="F3D8E8A06ABE2D36" modified="2016-07-06" version="1">MKIHSINREALKLILGASKTSHPNEFAGILRADKGVITEVLLLPGTFSSEQSAIMRLHMMPIDSTACGTVHSHPTPNPEPSQADLELFNKFGEVHIIVASPYKEESWCAYDHQGRGIELKVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC82</accession>
    <name>A0A133VC82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000051">
        <property type="protein sequence ID" value="KXB04061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04061">
        <property type="protein sequence ID" value="KXB04061"/>
        <property type="gene ID" value="AKJ48_03430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="315" mass="35484" checksum="6BF8FE9D90275926" modified="2016-07-06" version="1" fragment="single">PEENEKVVEEEEEFEKEEREVEVKEIGEDEIEIEAKNPDEEHPEEDEDEQRLKISTEEGAKFELEYEDLLAAGENEEGREVELEYEVEFDAIIEFADNNGNGLYDEGEEIYEYDLEDASFDPIQNTSENVSGVTVYTITMQTSDGVFKAIVHTSGKPITVNGENVTPNEVKIDIEITNFPYQENNSKLALKTELDSELEVEEEKREIEETDEEEVQVTSGNYGGFFSWKKTALVDGVSKPVKSTNISDDPEEGDRELYLIYEHGNKIVHDPKIGVRGAIAGPIAEINWTTVIVAAIVAALVSIGVTSLMLKRKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCB2</accession>
    <name>A0A133VCB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000052">
        <property type="protein sequence ID" value="KXB04034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04034">
        <property type="protein sequence ID" value="KXB04034"/>
        <property type="gene ID" value="AKJ48_03445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="168" mass="20306" checksum="96AC269C84E268FB" modified="2016-07-06" version="1">MHREVDVESLKKLRKKVDDPKVRDRITAVIMEVKGYERREMADPLSVHRETVRLWIKRFDESGVDGLWDEERPGRLSKLSEVEREQVRADLEQSPKESGYESEVWSTRMVLDHLREEYGVEYHPRYIQRFIRKLGFELKKPRPKHHKASEEEKKKYYQRVEEVKKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCG3</accession>
    <name>A0A133VCG3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000050">
        <property type="protein sequence ID" value="KXB04084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04084">
        <property type="protein sequence ID" value="KXB04084"/>
        <property type="gene ID" value="AKJ48_03375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="129" mass="14071" checksum="96B04490D79FB0AE" modified="2016-07-06" version="1" fragment="single">FHPPAVTRIFPPLKSALAHQLAPNFDVCVIEKEGLDQVGRKPCPGAVEKSWFEGLPSPVELGAVSRRVKGMKLTAGRKTHQVNFDGYVIDRNKFCRSLLETGIGEGCELIKERARADFKGGKIRVTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCG5</accession>
    <name>A0A133VCG5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="4 13">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpA</name>
        <name evidence="17" type="ORF">AKJ48_03320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4 13"/>
    <dbReference type="EMBL" id="LHYB01000048">
        <property type="protein sequence ID" value="KXB04143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04143">
        <property type="protein sequence ID" value="KXB04143"/>
        <property type="gene ID" value="AKJ48_03320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.600"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005726">
        <property type="entry name" value="ATP_synth_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01043">
        <property type="entry name" value="ATP_syn_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="15">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_Xtn" evidence="16">
        <location>
            <begin position="82"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="14">
        <location>
            <begin position="211"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KXB04143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="586" mass="65107" checksum="FB589198FB06AF53" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCI2</accession>
    <name>A0A133VCI2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ORF">AKJ48_03360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="LHYB01000049">
        <property type="protein sequence ID" value="KXB04120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04120">
        <property type="protein sequence ID" value="KXB04120"/>
        <property type="gene ID" value="AKJ48_03360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.608"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="51"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB04120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="397" mass="43553" checksum="1EBA2B5F65729702" modified="2016-07-06" version="1">MKMARGKFGDFGGRFANEILMPVLIELEEAFDKIYPTPEFQDELKNLLENYGGRPTPLYHAESFSELVGCKVYLKREDLVNGGSHKLNNTLGQAHLAKRMGKTRLITETAAGMHGVATVMAGNACGLETEVFMGAQDIKRQASNVKRMKLLGAKVTPVNIGSGVLKDAVSDTLREWTSCSRTTHYLMGSTVGPHPFPEIVATFQSVIGEEIKKQMLEKEGRPPNAIIACGSGGSNAIGAFRPFVDNEKVRLYFVEGGGEHLDADSSAAAFQLGKPGVIHGALMQTLQDEHGQIKPSKTRSAGLNYPARGPEISHLCKTGRVKACYAFDEEVFEAVKVMARNEGLIPALETGHAIAYMLNHKDEFSEDEVVVLNYSGRGDKDLETILRYFENEAWRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCN5</accession>
    <name>A0A133VCN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000047">
        <property type="protein sequence ID" value="KXB04180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04180">
        <property type="protein sequence ID" value="KXB04180"/>
        <property type="gene ID" value="AKJ48_03300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="416" mass="46613" checksum="920104B69407F814" modified="2016-07-06" version="1">MKERGQVFTLDMLFALVLVGAFISVSGQAYELTTGQTRSYSTRYSLERTANDAADTLVKSLGTPDNWEDNLESLETPGLAKADANNNPVQNEIDIRKLANLRDLCRWANWPVEPVSWLFGGTDNFEVRVIYRDLLAREPLADLDFDIENTLFGVEADIEAENEDGQIEAEVDLDWDGESESAPSFTMMVTGGGLTIKVIVGGGVIEVWYKTTLWDFWPEWDVEDSSGVENSLEVAVVKRLAFLRYGPALLREDTGKLVKLEKNLGTEHYEENFRLYEGELEMYDWYLVIRTAEQSENQVDEVRVKVNDQGQQYRYDPQSDGSEAVLPNDWMPTSRGHDVSHGGMENDSMLNAPPVVGLDNLDIWVKPWNDPATPGNDAEGDWARLSVVGIPACSPPEIAEIAPNKTPVTVEVLVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCT3</accession>
    <name>A0A133VCT3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000045">
        <property type="protein sequence ID" value="KXB04266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04266">
        <property type="protein sequence ID" value="KXB04266"/>
        <property type="gene ID" value="AKJ48_03215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.574"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="100" mass="11695" checksum="C9356ACC2E906C9E" modified="2016-07-06" version="1">MNEDKVVSAMDNLLCRKWTLRLLMNLQANSPRRFNEISNDLSGISSKTLSKRLKTLKAKSIIKRKSYSEIPPRVEYSLTEKGEKLIKSFDDVMKWAENWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCT9</accession>
    <name>A0A133VCT9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000045">
        <property type="protein sequence ID" value="KXB04268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04268">
        <property type="protein sequence ID" value="KXB04268"/>
        <property type="gene ID" value="AKJ48_03235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="172" mass="19832" checksum="B5E28E9A98EFEFEF" modified="2016-07-06" version="1">MEIRSFGEKPLIFGVKREDGKIFETPLRGNSALEFKSALRRADEEIGPVIVLDTDGHTSYPQATELVGILHRAVNRSEEGFVNELGIHSNGVENLWSHERRWIERARGYGSMRTLKRAVKAHQAYQNRVKNSPVPVWAFLEILVVNQNHTYFLFILHHTFFKEVPSNHRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCY8</accession>
    <name>A0A133VCY8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000040">
        <property type="protein sequence ID" value="KXB04318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04318">
        <property type="protein sequence ID" value="KXB04318"/>
        <property type="gene ID" value="AKJ48_03005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.512"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="326" mass="36866" checksum="CEC43D9634CB2AB9" modified="2016-07-06" version="1">MDKKTKILFTRRSFKPFIRRDLNILKKHFDVRVVRQLSLKNPISLLRRIPEILWADVTFSWFASHSTFFHVLLSKIFGKKSIVVSGGGDAAKMPEIGHGAVLSPIKRPFIWGTYLFADKVLAFSNSSKENILERMPETNVEPIYLGAIDTEKFRPGRKKDLIITVGEVIKSNLKRKGLETFVKTAKHLPDKQFVLIGEHKDDSIDYLKSIATSNVEFTGWLPFEDLLRYMQRAKVYVQVSAYEGFGIAMAEAMACECVPVVTNRGAIPEVVGETGFYVSYGDPEATAEAIKKALKSDKGKKARIRIKEKFHIKNREQNLTEAIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCZ3</accession>
    <name>A0A133VCZ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps11</name>
        <name evidence="7" type="ORF">AKJ48_03070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04295">
        <property type="protein sequence ID" value="KXB04295"/>
        <property type="gene ID" value="AKJ48_03070"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.549"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_S11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="130" mass="13798" checksum="F0DEC43367EC9DBF" modified="2016-07-06" version="1">MPEEGKWGVAHIYASFNNTIIHITDLTGAETIARYSGGMVVKSDREESSPYAAMKAADRAAEEAMDKGFRGVHIKVRAPGGSESKSPGPGAQASIRALARAGLEIGLIEDVTPIPHDGTKKKGGRRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD01</accession>
    <name>A0A133VD01_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps13</name>
        <name evidence="7" type="ORF">AKJ48_03080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04301">
        <property type="protein sequence ID" value="KXB04301"/>
        <property type="gene ID" value="AKJ48_03080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.551"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019977">
        <property type="entry name" value="Ribosomal_S13_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03629">
        <property type="entry name" value="uS13_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="153" mass="17043" checksum="8F22C0057EEDAE2B" modified="2016-07-06" version="1">MKGIVRLAGRDLKGSRRVQAALTSLKGVGASMAKAVVRATGLEGTEKIGSLPDETIKELDDVIHNPASHDIPPWMLNRRKDIETGEDRHLLGGDIEIAERADIGREKHVRSRRGIRHERGLPVRGQRTRSTGRKGMTVGVERKKLKMQKEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD15</accession>
    <name>A0A133VD15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000037">
        <property type="protein sequence ID" value="KXB04349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04349">
        <property type="protein sequence ID" value="KXB04349"/>
        <property type="gene ID" value="AKJ48_02880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="133" mass="15286" checksum="E1116B0D3FFB65FF" modified="2016-07-06" version="1">MWRKLAWQKSLLWRILVVIVFISAGGAPVSDFSSLSYWHAFRPWFNLPWFMELVMIGIVGYLSTSILVKVKVNPWHISILVVSLSSIGALLDSFLFYHWLWRESYILSSASFPLFAGVGCFLGAWKRPSQRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD25</accession>
    <name>A0A133VD25_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000038">
        <property type="protein sequence ID" value="KXB04340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04340">
        <property type="protein sequence ID" value="KXB04340"/>
        <property type="gene ID" value="AKJ48_02930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="95" mass="11100" checksum="373268E1ABAE0E0C" modified="2016-07-06" version="1">MRRKGPRRDNVDPKEVVLNAYRNGELVTIIYKDRNGTRTSRMIEPLEIVTNPYSGVRWIKSFCHLRQEERTFLLERVVDAIPADIELSVISKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD31</accession>
    <name>A0A133VD31_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000037">
        <property type="protein sequence ID" value="KXB04353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04353">
        <property type="protein sequence ID" value="KXB04353"/>
        <property type="gene ID" value="AKJ48_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="91" mass="10360" checksum="BD6B488AA329FFF8" modified="2016-07-06" version="1">MNFANRLGQTLYKGGSLFTRIRRTEFGWTEVIMPMGKCCICGGLGVFLAYGKWWCTRHYDLASNELRVLPCSRPEDEAEVQTAARLGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD40</accession>
    <name>A0A133VD40_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_02765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04376">
        <property type="protein sequence ID" value="KXB04376"/>
        <property type="gene ID" value="AKJ48_02765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.456"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="185" mass="21428" checksum="793FB89E031E8AF7" modified="2016-07-06" version="1">MRKSTRKLKSEKSEEILKRRMREWRKGPAIERVKKPSKIERARKLGYKEKEGVVVARARVRSGGRRKSRPSLGRRPKRMGVRKITPKKSIQRIAEERTARKFPNLEVLNSYPIGKDGKYHYFESILIDPNHPAITSDPDLSWVSNSSQRGRAYRGLTSEGKKTRGLRKKGKGSEKNRPSQRSARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD50</accession>
    <name>A0A133VD50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04324">
        <property type="protein sequence ID" value="KXB04324"/>
        <property type="gene ID" value="AKJ48_02940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="120" mass="13604" checksum="1FBE7F22295E96E7" modified="2016-07-06" version="1">MQGLRKKIHGARQHDLLLEAFFYGRFMITWIFYGIGSRRWPKEWISSIGESSLTDSYVRFSAFKPSVPIYLSGGEMRKLLFGDLSPNMVISLGDSPIWLTGIKAPVHEAGFPAPCEYEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD70</accession>
    <name>A0A133VD70_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ArsA_ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000034">
        <property type="protein sequence ID" value="KXB04393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04393">
        <property type="protein sequence ID" value="KXB04393"/>
        <property type="gene ID" value="AKJ48_02745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.451"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="307" mass="34692" checksum="505CA1D83F54F097" modified="2016-07-06" version="1">MTEASSFLMDLKRLVFFAGKGGVGKTTVSCAYALKCSKEGVDILLVSTDPAHSTDKVFETTLGNEPSMVREGLYAKQIDTEKESRKHMKAIENEMRQVVSPETLSNLKSYLEMAHSSPGVEEAAMLDAIIDTVRDMKTRKIVFDTAPTGMTLRLLNLPKFLDSWSSGLINRRKEDLERLGKIDGTESKTPIKDPLVEKLKERKRRLDFGKRILQEKSSIVPVLTPERLSVMETTESLKQLKELGIDIPGVIINKISKGLGEERMEYEKKVIEEIEEKFKILGRIPMMEEEIIGTKKLKDVSKRLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD80</accession>
    <name>A0A133VD80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04381">
        <property type="protein sequence ID" value="KXB04381"/>
        <property type="gene ID" value="AKJ48_02795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="83" mass="9366" checksum="76279FC3D698272D" modified="2016-07-06" version="1">MVEAIETNASIELPFSSPEEAEVIHDSLKPEELLPKTTRTKVDITRRKNILYLKINAKDTAALRAAVNSFLRWAVVARDMTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD81</accession>
    <name>A0A133VD81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000037">
        <property type="protein sequence ID" value="KXB04354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04354">
        <property type="protein sequence ID" value="KXB04354"/>
        <property type="gene ID" value="AKJ48_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="135" mass="14735" checksum="08C0E0256DA379EE" modified="2016-07-06" version="1">MVIGKEAWSEVYMSRVLEQIDARILKSLVVLAIISVAFNLLVLSGHGFEWWPLRGVRFLSNPALLTETPMFSLTGHVVSRICREVGQWFVSITTIIIISSIGLDIYLNSSLLSLSASISAGALLMGVWGIGLMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD87</accession>
    <name>A0A133VD87_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000034">
        <property type="protein sequence ID" value="KXB04391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04391">
        <property type="protein sequence ID" value="KXB04391"/>
        <property type="gene ID" value="AKJ48_02720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="69" mass="8157" checksum="77D474B59D95BA6B" modified="2016-07-06" version="1">MNFIFIISLAILALVILWIQRDAQRRGIERKVYWLWLFLIIPAFLFLRIIGVGIVLIAYYLSSRRFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDA2</accession>
    <name>A0A133VDA2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="5">BCAT</shortName>
            <ecNumber evidence="5">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ilvE</name>
        <name evidence="6" type="ORF">AKJ48_02680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000033">
        <property type="protein sequence ID" value="KXB04405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04405">
        <property type="protein sequence ID" value="KXB04405"/>
        <property type="gene ID" value="AKJ48_02680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.436"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="307" mass="34501" checksum="2709A6B350FDB066" modified="2016-07-06" version="1">MALTPTKSIWMNGEFVPWDEAKIHVLTHTLHYGLGVFEGIRCYNTSEGAAVFRLKDHMKRLENSAQLVRMELPYSIEELANAVRETIKENELEECYIRPIAFYGYGIMGLNPQDSKVNVAIAVWPWETYLGEEGLEKGIRATISPWRRIRPEILPPQSKTVANYANSILAKLDALDKDYDEAILLNMDDQVAEGPGENLFIVEDGTVITPPLSSGALGGITRDSIIQIAKDEDIPIREEDLTVERLLKADEAFFTGTAAEVTPIREIDETTMGDGKRGEITGKLQSIFFDTVRGKTAKYKDWLDYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDA5</accession>
    <name>A0A133VDA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000034">
        <property type="protein sequence ID" value="KXB04397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04397">
        <property type="protein sequence ID" value="KXB04397"/>
        <property type="gene ID" value="AKJ48_02740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="89" mass="10317" checksum="5A8B7096F9FB0FB6" modified="2016-07-06" version="1">MEIGGKLKKFFSSSLDYGHLVRVEAYDRMDAFLLLCFSDALGIPNPHSYYMSELLPYIGEDLSRWARRMAGDRDEGLSHLTYKLDHHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDB0</accession>
    <name>A0A133VDB0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000031">
        <property type="protein sequence ID" value="KXB04433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04433">
        <property type="protein sequence ID" value="KXB04433"/>
        <property type="gene ID" value="AKJ48_02615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="1">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="193" mass="22628" checksum="EC14114C31FAA928" modified="2016-07-06" version="1">MPKEEKTEKEIEEERIEAIREKMGRAAQLILFKHHRQPGAKSWELKRALGKKYPEIVKMLDQELQKIGLTIKEVSEGEDKPARYYATMADHPRLSDRTFGWRIDDMAALVITLSYIQSKRGRAPEKEVKEILREKFPKWRVDQILNKFTKKGYISEDDEGILYIDWRTRAEIDQKELLGRLIGKEGELEDVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDB8</accession>
    <name>A0A133VDB8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04440">
        <property type="protein sequence ID" value="KXB04440"/>
        <property type="gene ID" value="AKJ48_02535"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.370"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="177"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="319" mass="34877" checksum="FAC7D8318B0A0ACA" modified="2016-07-06" version="1">MFNYFLQVMIFLGGAALLIFSVEKFVGNLVRTSYTYGISAFILAVIFAGMDFENWGFGISAVLKGVPDIALGSAIGSAMFLMGAAIVIGGFITPFDSKTPRDYLLLMIMSPVMLLLFLLDGMLTRIDGVIILFIFALILLYLVRRERTSKRARLRDEEVEEAAEELGKTSEKKWIYPTLMIIFLIGIVIGAELSVRGAKELVQNLGLSGTIFGMTIVGLVMSLEEVLLVVEPVRKGEVSVATGNIVGSLIFFSLGNIGLLAAIRGFSISESVLTFYWPVMFATILLVGVFLVRGKIGRAEAIILAGIYLAYWVISYGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC0</accession>
    <name>A0A133VDC0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein AKJ48_02550</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04443">
        <property type="protein sequence ID" value="KXB04443"/>
        <property type="gene ID" value="AKJ48_02550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="143" mass="16173" checksum="287451CC27A1E13A" modified="2016-07-06" version="1">MKIKVRAKVHPTEDLGKLEEAIKNIFPKLKLSQTEDYLEGESTNPEVLEHLKNQLGLQAIRDSARKALRSGREDNLIHFKINRQAATVSKVSFTEGETPLGPIEVEIQSKEPDLVTDYLTPRTREGKPVRKVTLEELKTTEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC2</accession>
    <name>A0A133VDC2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="6">DHOD</shortName>
            <shortName evidence="6">DHODase</shortName>
            <shortName evidence="6">DHOdehase</shortName>
            <ecNumber evidence="6">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrD</name>
        <name evidence="8" type="ORF">AKJ48_02655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="6"/>
    <dbReference type="EMBL" id="LHYB01000032">
        <property type="protein sequence ID" value="KXB04421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04421">
        <property type="protein sequence ID" value="KXB04421"/>
        <property type="gene ID" value="AKJ48_02655"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="7">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="304" mass="32130" checksum="FF0C83C7C796842C" modified="2016-07-06" version="1">MTSENLRVKVGDLQLRNPTLLAGGILGLTGASLKRVWESGAGAIITKSIGLESRKGYPGPSVAQTPCGLVNALGLPNPGIEYALEEIKVARESKATLLGSVFGRNVEEFEVLASKMEKAGVDAIEFNLSCPHAEDIPMIGQDPKLTKNVLKVRDNLETPIWVKLPGNTHLSNLVEVAKSAEEGGADALVISNTFPAMAINARAERPILGHKVGGLSGQAIRPIGLRLVYEVYKEVEIPIVGAGGVASGENMIEYVLAGASAVEVGMSIIESGLGIFQEICEEASSYLEGRKIKDLVGLAHQNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDD8</accession>
    <name>A0A133VDD8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AKJ48_02560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04445">
        <property type="protein sequence ID" value="KXB04445"/>
        <property type="gene ID" value="AKJ48_02560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="11">
        <location>
            <begin position="180"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="12">
        <location>
            <begin position="315"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB04445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="424" mass="50018" checksum="A8A6151F24A81A39" modified="2016-07-06" version="1">MELTQKIKIGPSEEQEKVLTSLSETCRLLYNFSLAERIENWKKNKNKPKDEREYITYVDQQNKLPGLKKKYPRYKWVYSKVLQMTLRKLDADYKSFLALKKNGDEKARPPRYKGKKYFTTLCYNQSGFKIEREKISFSHNHPSDTQLEFEVPEKFDFENKNVKQVEIFRDGVKKEYYVSITYEVETPKYVDNGLYQAFDLGVIKHTGVNLHRKFVEFWNPRPDKYWQPKIREVQSKRDHCKKGSHRWMRYNEKLWKMRRKCANQMRDWQHKASRKIVNNTKANTIIIGKLDPKKMAEGGENKGLNWSLQNTGMIGRFARFLAYKAELVGKKVIEISEENSTKECCICGKKENRPLYERTIKCDCGNVMDRDRNSSVNHLKRFLSQKRPVDGQSILAGMGLLRQTGSGYAYRPTPEYSQEAPCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDD9</accession>
    <name>A0A133VDD9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04441">
        <property type="protein sequence ID" value="KXB04441"/>
        <property type="gene ID" value="AKJ48_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="78" mass="8320" checksum="397F724593495F02" modified="2016-07-06" version="1">MVKAYSLVSVEPGKTPEVSKAIEKMGGVKTVEAVAGPHDLVVRIEVDSLEKLTNTVFGDIRSIHGVTSTTTLIVVELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDE1</accession>
    <name>A0A133VDE1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04462">
        <property type="protein sequence ID" value="KXB04462"/>
        <property type="gene ID" value="AKJ48_02485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="279" mass="32568" checksum="52F4BE425C5C1421" modified="2016-07-06" version="1">MENSNQEDARLKITEFTDPWCTWCWGSEPILRRIMEAYGDQVEIDFVMGGLVEDMETFYDALNNISAPEHVPPPHWKEASERHGMPVDEKIWLEDPPRSTWPSNIAYKAAEFQGKKLAHKYLRRMREAAASEGKNLEKKEVLVELAEEVGLDREKFESDLKSDDAIKAFQEDRELSQSHGATGFPTFLIERREGEKWLRGYHSFRYFKELLEELEPDLEEEKPGTILEFVENYDHVATREVQEVFDLSKSEALEKLRKLENKGKIKSIERGNGLFWEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDF7</accession>
    <name>A0A133VDF7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04465">
        <property type="protein sequence ID" value="KXB04465"/>
        <property type="gene ID" value="AKJ48_02500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="77" mass="9242" checksum="238AEC7A94AC1D3C" modified="2016-07-06" version="1">MLLNFMEDPQQWLREYHSRSNVESGFSTFKRDFLAPLRKCIHRRRKAEAFARVCDYNLKRVSRLHHQEGLPIPWVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDG5</accession>
    <name>A0A133VDG5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps14P</name>
        <name evidence="3" type="ORF">AKJ48_02455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04489">
        <property type="protein sequence ID" value="KXB04489"/>
        <property type="gene ID" value="AKJ48_02455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.353"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="50" mass="5810" checksum="69412B18B8C71EF9" modified="2016-07-06" version="1">MTNKKRDKKKGANICSRCGSRGAVFQRLGLNLCRRCFREVAPEMGFKKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDH4</accession>
    <name>A0A133VDH4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="3 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adkA</name>
        <name evidence="9" type="ORF">AKJ48_02405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the archaeal adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="3 8"/>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04490">
        <property type="protein sequence ID" value="KXB04490"/>
        <property type="gene ID" value="AKJ48_02405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00234">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023477">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="173" mass="19783" checksum="88208763DC5EBC0A" modified="2016-07-06" version="1">MDKALEKLREEGQDYQLLNYGDLMLEIAKEEKGVKDRDKMKNIKLETYRDIQKEAADSIAEVRKEIPVLVDTHCTIKKPEGYYPGLPQWVLERLQPEEILIIEALPKEIAGRREKDASRKRKKELGEAIAEHQELNRAIATSYAMMVGAGVRIIKNREGKIGEAVQKVVEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDK4</accession>
    <name>A0A133VDK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04515">
        <property type="protein sequence ID" value="KXB04515"/>
        <property type="gene ID" value="AKJ48_02335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="77" mass="8771" checksum="AC1BBF302DF674DB" modified="2016-07-06" version="1">MTLTSSVRVLLTEKYCEAVTLLAKNEDKNTITATFLRPSPGKFTVIPPSLWRKEIYKEKIDGFARLTNNIRAIKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDK6</accession>
    <name>A0A133VDK6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000025">
        <property type="protein sequence ID" value="KXB04533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04533">
        <property type="protein sequence ID" value="KXB04533"/>
        <property type="gene ID" value="AKJ48_02270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="96" mass="11347" checksum="02D19FA996EC95D0" modified="2016-07-06" version="1">MPEYPESVLTESRKGKTEVRALASKGEFIMCEYLDPESLEQTEKKKKLILKREDGETEEYFIIPMKQKGRDLLITPKEKSGEYIFWNKTEEKIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDK9</accession>
    <name>A0A133VDK9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04511">
        <property type="protein sequence ID" value="KXB04511"/>
        <property type="gene ID" value="AKJ48_02310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="322" mass="37430" checksum="F2A93C84F79EEB0C" modified="2016-07-06" version="1">MSKYIGLDVHKNKCHAIIMSEDGEIQKQEEFKNDTLGLELFFDGIDDAQIAMEATYSWQPTYQWLEEKGYDVKLAHPKKTRIIGEAKIKTDCRDSEALAHLLPESYVPPEEIRKLRQKLYHRTYLVRERTKFKNKIHAELAKQGIEFDESPWTKKGKQKLNELKIDEINDYLAMIKALNERINRLSRELKQEARESEEANLLITIPGVGYFSALSILAEIGNIDRFSNPEKLCSYAGIIPSTRQSGHITRRGSITKEGRRCLRWVLVECIWSHLTHTSGTRLTRFFRRIAKRRGKKVAVVATARKLLVAVYWMLKRGEEYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDN1</accession>
    <name>A0A133VDN1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04552">
        <property type="protein sequence ID" value="KXB04552"/>
        <property type="gene ID" value="AKJ48_02150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="160" mass="18499" checksum="6FC4692411334F41" modified="2016-07-06" version="1" fragment="single">ISSNLFNKNGLYPYVPGAGNMDEGIKLPRKWGLIRCGGRNRNKNPKCSQLLIVKRGQKSKKCPNCGTQRSLEGRRREVLAWSDSQGRIRRAMGELKGSTSKVFRKLFILRIHFFTVKTLKNTLFHILGKRKNKIPQYSIIQSPIINFFNIYLLHIQEKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDP2</accession>
    <name>A0A133VDP2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04562">
        <property type="protein sequence ID" value="KXB04562"/>
        <property type="gene ID" value="AKJ48_02175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="89" mass="10008" checksum="9CA269071EFBED67" modified="2016-07-06" version="1">MKTFVTTFNAVIIGVLLANYISIYREIRSKFTLSLIVFSVALLLFAVSSNPLIPFFLNFHPGPILGIFTFLPNIFASIAVLMLLYLSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDQ0</accession>
    <name>A0A133VDQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04578">
        <property type="protein sequence ID" value="KXB04578"/>
        <property type="gene ID" value="AKJ48_02140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="79" mass="9136" checksum="163018695C288677" modified="2016-07-06" version="1">MVQPKPHLFEIRRTPQGTPPKMKEENENMGDKKSKSKDKSLDKLVSETIDSLSKMGEGIKESIDPEELKSQIKKWMKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDR2</accession>
    <name>A0A133VDR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_02090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04580">
        <property type="protein sequence ID" value="KXB04580"/>
        <property type="gene ID" value="AKJ48_02090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.277"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="157" mass="15837" checksum="A5AF3BD3EB4E233B" modified="2016-07-06" version="1">MYDLVFVALAIGLAVTIPGFISGLGVGLAGVAAAGATAEKPGEFSRMFVLEILPGTQGFYGFIGGIMIMMGTGILGGTFGLPEGVTGLAVLGAAVPIILQGFTAYPQGKVASASVSAISKNPKVFGSSVIYTVMVETYAILGFLTGFLLIYGLGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDR7</accession>
    <name>A0A133VDR7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FeoB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AKJ48_02250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000024">
        <property type="protein sequence ID" value="KXB04544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04544">
        <property type="protein sequence ID" value="KXB04544"/>
        <property type="gene ID" value="AKJ48_02250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.312"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB04544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="657" mass="70687" checksum="BB2E70A54B7CB413" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDU5</accession>
    <name>A0A133VDU5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ORF">AKJ48_01930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04623">
        <property type="protein sequence ID" value="KXB04623"/>
        <property type="gene ID" value="AKJ48_01930"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.215"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="156"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="261" mass="27933" checksum="CE8D5E84FED08609" modified="2016-07-06" version="1">MKIGVIGCGNLGSSIIKGLLKSESLKPEAIIASDPDKEKLEELGKLGVKTTTDNQEATEESEVIIIAVKPSLVGKVLEELGVSKEKLIISVAAGVSTDFLERHTDARVIRVMPNICGRVAEMASCYTLGKFATKDDEKLVKDLLWVLGLTFKIDKELMDTVTGLSGSGPAFIFLVIQGLRDAGIDLGLSEDVALKLASQTVKGSGEMALNSGESLEELIDMVSSPKGTTIEGLKILEDQEVREAFEDAVRAAVKRSKELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDV1</accession>
    <name>A0A133VDV1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protease subunit, stomatin/prohibitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04628">
        <property type="protein sequence ID" value="KXB04628"/>
        <property type="gene ID" value="AKJ48_01960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.220"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="271" mass="30593" checksum="69321E11B413D91C" modified="2016-07-06" version="1">MVSWLLGLIIFIIIVIIVILALAIKILPEYERAVHFRLGRFIGLKGPGIFLIIPFVDRIKRVDLRVLDLDVPQQRVITQDNVSTNVDAVVYMRVFDPEKSILKVEHYYRATSRLAQTTLRDVLGQVELDALLSKREELSERIRKILDEETDAWGVRVTNVAIQNVNLPEEMVRAIASQAEAERNRRARVKLAKGEKEAAEQMAEAARIYGKSDAAMRLRELQTLVEIATEQNLVVVAPSKIGTELGGIAGLTSALQKQSERRKSKEEEEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDX1</accession>
    <name>A0A133VDX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04648">
        <property type="protein sequence ID" value="KXB04648"/>
        <property type="gene ID" value="AKJ48_01890"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.209"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="180"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="364" mass="41126" checksum="CD9FB0443AF22BC0" modified="2016-07-06" version="1">MKIALVTDTYHPQVNGVVSSVDTIAEELEKEHEVHIFAPTRSERAYSFNSFPFYLWPDYRIAYVRAKTLAKIFEEKDIEIIHVHTPFSLGVSGVGAARHLTLPAVGTFHTLLPEYTHYISETLGLLLRRFGWRYVNWFYGRFNAVTVPSTPIKESLVKRGLKNVHVIPNAVNVDLFHPGKEPPSSDPCILFVGRLGKEKRLEVLIDAASSVLEEYPKAKFQIIGRGIHEDWYKKIVKEKGLSNNFVFEGYVSSPDLIKAYQECDIFAIPSDTETQGLVTLEAMACEKPVIGANALGLKDVITHEVDGYLFQPGNSSELSDYLLQLLEDDKQRREMGKKAREKAKEFSAERIGGQWVNFYSSLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDY4</accession>
    <name>A0A133VDY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04663">
        <property type="protein sequence ID" value="KXB04663"/>
        <property type="gene ID" value="AKJ48_01770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06067">
        <property type="entry name" value="H2MP_MemB-H2evol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004420">
        <property type="entry name" value="Pept_A31_hyd_mat_HycI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00142">
        <property type="entry name" value="hycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="158" mass="17088" checksum="9FBE56AFFFE47C2C" modified="2016-07-06" version="1">MNSNLLNIPSDAQVAILGVGSELRGDDAAGVKVVRNLKEKLDSPKLLLIDAGSVPENFTSKVRNFNPTHIILIDAVDFGEEPGKIAHVNPEDIVGQVTSTHRLPLSILMNYLRERTGAEVILIGIQSAQVKMGSEMTAQVEDGVRELVGFLTRKFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDZ3</accession>
    <name>A0A133VDZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04645">
        <property type="protein sequence ID" value="KXB04645"/>
        <property type="gene ID" value="AKJ48_01875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="142" mass="15566" checksum="6EA2D20C0C4B80BB" modified="2016-07-06" version="1">MSETLSEVVKARGHPKITARHSTTFMITKDEEIGTEADCVVGVKADKAAVDLKKEVKLAINSGASVEVTLEANDIRETIKGQGHPDLQLSDSNDLVIRESDYTCGRTLMIKADKAADDLSRDLIERLKNPDTTLKMTIKVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDZ5</accession>
    <name>A0A133VDZ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_01820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04676">
        <property type="protein sequence ID" value="KXB04676"/>
        <property type="gene ID" value="AKJ48_01820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.194"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="236" mass="26708" checksum="098B4B870B935E3A" modified="2016-07-06" version="1">MVIEDLTKYYDDFLALDEMSLKIMENEDVALLGPNGAGKTTTLKLLCGVISPSSGTAYIDGVNVFEERERAVSKLGVILETPEFYPFFTPEETLSYLGRLRGMKKRNLKSRIKKVIKLVKLEEWISVKIEKFSRGMKQRLAVAQALLHDPPILILDEPALGLDPRGMADVRNILKEARKEKTVFLASHQLGEVTQICDRAALIDRGKLLTYESIPNLKKKYKSFEQAYLELTEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE14</accession>
    <name>A0A133VE14_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl24e</name>
        <name evidence="6" type="ORF">AKJ48_01735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04693">
        <property type="protein sequence ID" value="KXB04693"/>
        <property type="gene ID" value="AKJ48_01735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023438">
        <property type="entry name" value="Ribosomal_L24e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_L24e-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="PTHR10792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="63" mass="7464" checksum="5689247A29A8C514" modified="2016-07-06" version="1">MPATKRCSFCDERVTPGRGIMYVKRDGRIQYYCSSKCRRNAELGRKPHKVKWTKRSREARGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE15</accession>
    <name>A0A133VE15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_01750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04696">
        <property type="protein sequence ID" value="KXB04696"/>
        <property type="gene ID" value="AKJ48_01750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_S6e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_S6e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="PTHR11502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="128" mass="14040" checksum="7D47C3EA3286B76A" modified="2016-07-06" version="1" fragment="single">MVRVVVSDPESGKAYQIEPDESSVGRLMGLQIGQSFEGDIVGLSGYQLLVTGGTDKDGFPMRSDVRGPGRKRIVLSKGPGYKPREEGMRRRKLLRGRTVSQDIAQLNVKVTERGEKDIQEILGPKPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE32</accession>
    <name>A0A133VE32_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein L8e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rpl7ae</name>
        <name evidence="10" type="ORF">AKJ48_01725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04691">
        <property type="protein sequence ID" value="KXB04691"/>
        <property type="gene ID" value="AKJ48_01725"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.173"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_L7Ae_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_L7Ae_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="9">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="124" mass="13549" checksum="73781E4C8AD8EEFA" modified="2016-07-06" version="1">MAEKPIYVRFEVSKELADRVYEAVETTRDSGELRKGTNETIKAIERDNAELVVIAEDVDPPEIVAHLPPLCEEKDIPYAYVPNKLELGAAAGIEVGAASVGIIDPGKASDEVTSITREIEELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE39</accession>
    <name>A0A133VE39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04712">
        <property type="protein sequence ID" value="KXB04712"/>
        <property type="gene ID" value="AKJ48_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="93" mass="11111" checksum="8CF826F7A3F55844" modified="2016-07-06" version="1">MRNQGGTDILGVPHAVKKWADWSEEDWRDELPDRRRRIRKVWESVEEVVTALQKLDWEMVAENYYQGTQYVDFKKGDYVVRLEIGDITDRLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE44</accession>
    <name>A0A133VE44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04709">
        <property type="protein sequence ID" value="KXB04709"/>
        <property type="gene ID" value="AKJ48_01625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.153"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="205"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="390" mass="44414" checksum="0860C5942B5AB1E0" modified="2016-07-06" version="1">MNDNEIPDHWEWGELRDVSQRLTSTVDPSENGGKLFEYYSFPAYDKNRAPSLTKGKEIGSRKRELHGGELLISRLNPRKGRVWKVSSSKRSKIASTEFVALELNENEVNKDYLYYYLKSANVTKVLVSKVAAATKSRKRVQYSDVMSLKIPIPPLGEQKKIAEKLDKIFKNVNEAKEAQQKAEEIKEKAMRAAISSLFGSLSAERVKLENKCEIIMGSSPPGKSYNEKGVGKKFLQGPKEFGSEYPQTNRYTSEPTKLCEEGDILITVRATLGKLNRADREYCIGRGLAALRTKNDLNQDFLHYFLLIQDHYWSRVSSGSTYKSITKTNLKNLKVPVPPPKEQEKTVEKLDKIREKVNNMWDGFKRRKEILEILPKAVLDKAFTGELVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE66</accession>
    <name>A0A133VE66_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B12-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04740">
        <property type="protein sequence ID" value="KXB04740"/>
        <property type="gene ID" value="AKJ48_01550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="193" mass="21171" checksum="B17501D1390BF73A" modified="2016-07-06" version="1">MVIEEKLAGGASPADIKDTLSKEMLEIGRRYIDGEIYLPKALIASEIFEEILEEFDLHEGDIGKIAIGVVGPQVHEVGKNLVATWLRCVGFKVLDLGVLAPPERFIEVLKKEEVDIIAISARLTPAICAMSQVIRLLEKESLRKEVKVIIGGIAVSKELSREIGADSYASDFMDAVSQCKKLISKNRASESSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE78</accession>
    <name>A0A133VE78_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPF0020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04735">
        <property type="protein sequence ID" value="KXB04735"/>
        <property type="gene ID" value="AKJ48_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="3">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="823" mass="96140" checksum="166A4EF6C05FAF09" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEF3</accession>
    <name>A0A133VEF3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04777">
        <property type="protein sequence ID" value="KXB04777"/>
        <property type="gene ID" value="AKJ48_01415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="88" mass="9994" checksum="82D16344F1DB0F4B" modified="2016-07-06" version="1">MSEVVKVGKKGQITLPKEIREKEGLKKGQLLEVKEVGGGSIFLTSIDRKKEADAALRLLGKNVKMTDKEVVEYCRKIREEVFQEWSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEF5</accession>
    <name>A0A133VEF5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04832">
        <property type="protein sequence ID" value="KXB04832"/>
        <property type="gene ID" value="AKJ48_01290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="90" mass="10182" checksum="F8E6908A15205DF9" modified="2016-07-06" version="1">MLIQGDLQKKAGTKKIRTPIEDQETIDTLLIKISRRAPKLVETILDPRTGDLNEDFEVLLNGRSIQQLSGLHTRLKDEDEVTITPAETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEF6</accession>
    <name>A0A133VEF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_01285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04826">
        <property type="protein sequence ID" value="KXB04826"/>
        <property type="gene ID" value="AKJ48_01285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="176"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="419" mass="48518" checksum="0A1F4D479D2D076E" modified="2016-07-06" version="1">MKVLRTEKCKIENYSQVVDRIDELSISVCKLWNVARYKCEREWRKTGKIPSESKLKSKLKEHRRYRELHSQTAQNVIEELWNAFKSWFEKRKNDSKARPPGYRRKNGRYPKASVTFKKSAICHDKKNKRLKLSNGRENSSLLVEYKSRPEVDLDRIQVVRLAWNGDRWQIHITHRKEIEPQSPGAQVCAIDLGVNNFATIVYDDGTSELYPENKLKEDEYYFLKKIAKCNKSNSNKARRLHKKRGRRREHFLHALSKEIMGRCEEKKVGRIIVGNLKSIRENETKNNNNYNLKLGQWPYEKFVQLLTYKAEKTGIEVVKMDESHTSQKCPRCGVIDRKNRVERGLYKCSNCGFTIHADVNGALNLLQKVTALSGSNGSVAEPVVNLFAVRSGISPSGCEEGKFHQAEQLQTLNSQPHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEI5</accession>
    <name>A0A133VEI5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_01250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04856">
        <property type="protein sequence ID" value="KXB04856"/>
        <property type="gene ID" value="AKJ48_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004767">
        <property type="entry name" value="SecD/SecF-like_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00921">
        <property type="entry name" value="2A067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="203"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="624"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="759" mass="83114" checksum="8C4F6B7718642E19" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEJ0</accession>
    <name>A0A133VEJ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04870">
        <property type="protein sequence ID" value="KXB04870"/>
        <property type="gene ID" value="AKJ48_01080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="365" mass="41006" checksum="3DE78D82585E4C8F" modified="2016-07-06" version="1">MGEKKILVAGGGPAGLNCAYWASKDGHEVTVFEVEGELASKPCGELISDEALDFTPLNNDSSWVLNRVRRCLIYCDGKFIRELEPSSRPDIPLALLRGYSIDKKGFLQDLKSAAESAGARIHFNKKVTHKNIHDEEFDMIVDATGYPRVLGRSVGVNDGSERLATCKMGYYKGELNPDTTILNMLDRGYAWLFPHDELINFGVGGFYDKKALDKLYEKNIRTFELEPPHENLKPRTTPIFLGGPINQLRKEKLIITGEAAGTTMPTTGEGIRFALWSGSICYKKNYEELFANEYGKKLKFGRKLLEVILELNVEERLKIANGSPEFLSALAGGDLPRIRDLAQFPWLIRYIGKLWRPFLPTKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEP8</accession>
    <name>A0A133VEP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_00905</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04922">
        <property type="protein sequence ID" value="KXB04922"/>
        <property type="gene ID" value="AKJ48_00905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.630"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="245"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="518"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="766" mass="84249" checksum="9D094CEB62EA6D79" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ7</accession>
    <name>A0A133VEQ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AKJ48_00980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04894">
        <property type="protein sequence ID" value="KXB04894"/>
        <property type="gene ID" value="AKJ48_00980"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.704"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="77"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB04894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="535" mass="61173" checksum="8752314C074D847F" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VER6</accession>
    <name>A0A133VER6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04932">
        <property type="protein sequence ID" value="KXB04932"/>
        <property type="gene ID" value="AKJ48_00960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.641"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="96" mass="10780" checksum="0C6AAA94B72DDB73" modified="2016-07-06" version="1">MPQLRIRHTQGETLVTICDEELIGEKFEEGELKLEVKNSFYEGKEASVEECINALKEATIANLVGSIVKHAIKAQIINPKNVLRIQDVPHAQMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VET3</accession>
    <name>A0A133VET3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04958">
        <property type="protein sequence ID" value="KXB04958"/>
        <property type="gene ID" value="AKJ48_00850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="73" mass="8470" checksum="2654C84C43603E22" modified="2016-07-06" version="1">MSTVFNPSAKSISKRINLLLHNRGVLLHGIKKIESNKKKVLKVFQKLFSRRNFQCHVQEGKMNSFNPLFSDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VET6</accession>
    <name>A0A133VET6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eif2b</name>
        <name evidence="11" type="ORF">AKJ48_00965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04937">
        <property type="protein sequence ID" value="KXB04937"/>
        <property type="gene ID" value="AKJ48_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00232">
        <property type="entry name" value="eIF_2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004458">
        <property type="entry name" value="TIF2_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00311">
        <property type="entry name" value="aIF-2beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="10">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB04937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="136" mass="15231" checksum="1A9DC36B49F0682E" modified="2016-07-06" version="1">MGEDYDELLDHALDQVPEFTAEKERFETPEVDIDVSGNQTALQNLKSIADELNRNPDHLMKYLLGELGTAGNREGARGVFQGRFGKESVQDRINRYVEEFVLCPECKKPDTKLVKEGRITLLKCEACGARSSVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEU8</accession>
    <name>A0A133VEU8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04963">
        <property type="protein sequence ID" value="KXB04963"/>
        <property type="gene ID" value="AKJ48_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="192" mass="21091" checksum="E1DC1F4CCD6567E4" modified="2016-07-06" version="1">MGEITLKIDEREIKAEEEKTVLEVAKENGIEIPTHCHREPYEPVGACRLCLVEVQVPGAKPELKPACTYPIREGLKVKTSTAKVQEVRKLTAELLLARCPNSEEVRRIAEKLGVKKSRFSPKDLDCTLCGLCVRACKAATGDNVIVFAGKGLNVEILTPSELSSEECQSCGVCAEVCPTNAIKMLEIEEEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX2</accession>
    <name>A0A133VEX2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2 4">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tmk</name>
        <name evidence="6" type="ORF">AKJ48_00610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2 4"/>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04982">
        <property type="protein sequence ID" value="KXB04982"/>
        <property type="gene ID" value="AKJ48_00610"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.387"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="5">
        <location>
            <begin position="9"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="203" mass="22617" checksum="F4D36B9A44733940" modified="2016-07-06" version="1">MMKGKLITLEGLDGCGKSTHAKLLANWLRDEGHEVEITDEPTDNPIGKILKKALRGEIEISLETEALLFAGDRALHVADDIGPALEGGKIVITERYIYSSLAYQTARGLSDEWVKSINKPAIDPDLAIVIDVPAEVGFERIKTTRELDTFEQDLDLQKRVRERYKEIVKGEGIIIVDGTREVDKVQSEIREQVKEVLHADLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEY1</accession>
    <name>A0A133VEY1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_00820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04964">
        <property type="protein sequence ID" value="KXB04964"/>
        <property type="gene ID" value="AKJ48_00820"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.530"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041107">
        <property type="entry name" value="Rimk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18030">
        <property type="entry name" value="Rimk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="105"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="284" mass="32110" checksum="BC082647D803DCDD" modified="2016-07-06" version="1">MGIFRSSEEDWNVRQLKLEARKRDIDCVTFPLTKLVARLNDKPRVSCQGHDLEDFNALIVRWAPRGSAEQIVFRMNALHRLENLGVRIVNPSIAIERCADKFYECSLLEDKGIPVPKTIVAEKRKDAKRAFKELKDVVVKPLFGSLGTGMLRVNNEDLAHRVFSALEFGRNIYYIQEFIPHENRDLRAFVLNGEVLASMERVSKSWKTNIAKGGEARACELSPELREASVKASKVLGCEYAGVDIIKSEGGFYVTEVNAIPGWKGLQSVTDVNITREIVNYLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEY6</accession>
    <name>A0A133VEY6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate kinase</fullName>
            <shortName evidence="1">PoK</shortName>
            <ecNumber evidence="1">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_00730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05003">
        <property type="protein sequence ID" value="KXB05003"/>
        <property type="gene ID" value="AKJ48_00730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PTHR42282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="3">
        <location>
            <begin position="213"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB05003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="302" mass="32227" checksum="83AE4D73A2C1D85F" modified="2016-07-06" version="1">MNKASAFAPGHISGFFQVCDEPEDPAQIGSRNCGPCITAGVLTEVEVDENSSGIQVYINGEEAEYARTTKTAVKGTLKAMGQTAGVKVNHSVQAPIGAGYGLSGAGTVGAVLALSNAMSLRFSLTDISEIAHRAEIACKTGLGDVGPQMFGGLVISLEPGSSPYGEWARIETPNDLQAVCGTWGPVSTSELLKDPKFREKSKELGKEALDKLMRDRSMETFMKTSQEFARKLGVLDEEFEEVLNELSKATPIGASAVMLGRAIFALARKSEVEEVQSKFSDYFEPESIMVTSLDLQGARSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF03</accession>
    <name>A0A133VF03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_00485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05029">
        <property type="protein sequence ID" value="KXB05029"/>
        <property type="gene ID" value="AKJ48_00485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="132"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB05029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="329" mass="38214" checksum="7A7491C0E5D68198" modified="2016-07-06" version="1">MEGLIMESKSRVGTRQVSNSELIEDFLKDLELQGKSCGTIRDYKSYVSKFANFLESQDGEGSFLQVGAETLRDFLEFLKDDKGLSEKTLGNYFSGISSLYEYLKFEGLVKGNPVNPVRKRYIKISRGNSNDSERQLISIDEMSSLIRSILSARDKAIIVLFAKTGIRRNELSAIDLSDIDWEDKSIKLKEKFRQGKRSNLTVFFDDECEKVLGRWLDQRDEWLKDKETEALFLNSYGTRLKRSGIQRVVTKHAERMGLHDPDSDKLSERFTSHCFRHWFTTHLRRSGMPREYIKELRGDSRSEAMDIYHHIDREELRESYLAHVPKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF09</accession>
    <name>A0A133VF09_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">radA</name>
        <name evidence="10" type="ORF">AKJ48_00695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05007">
        <property type="protein sequence ID" value="KXB05007"/>
        <property type="gene ID" value="AKJ48_00695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.404"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="75"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="9">
        <location>
            <begin position="251"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB05007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="310" mass="33612" checksum="BA0431AA65996FBF" modified="2016-07-06" version="1">MDELENLPGVGPATAEKLSDSGFDTLESVATATSHELTGAANIGTQTATKIIRSAREAADMGYEKATEVMERRKLVGTISTGSDALDEMLAGGVETQAITEVFGEFGTGKTQLAHQLSVNVQLPLEKGGLEGRVIYIDTENTFRPERISQMAEAVDLDPQEVLENIYVARACTTDHQMLLAEKASDMAEDDGVKLLVVDALMSIFRTEYVGRGALAERQQKLGRHLATLHELSERHNLAVLVTNHVMSNPGTFFGDPTKPIGGHVLGHAATGRIYIRKSKKNTRKAKLVDHPGLPPKKVKFQIANEGIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF17</accession>
    <name>A0A133VF17_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05031">
        <property type="protein sequence ID" value="KXB05031"/>
        <property type="gene ID" value="AKJ48_00495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="98" mass="11238" checksum="F0A7954B30B4691C" modified="2016-07-06" version="1">MSSIGIIPKFKSEEEKTRQKVRPVYLRPWEELVGLLEDVSVDEGVAILEISREVKIKLPPEKLAELEDVVGEEVRVLRTDGFKIDEFLVDIREETDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF26</accession>
    <name>A0A133VF26_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05041">
        <property type="protein sequence ID" value="KXB05041"/>
        <property type="gene ID" value="AKJ48_00560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="369" mass="39991" checksum="C9C8A443E20133E3" modified="2016-07-06" version="1">MSDKAEVVIIGGGIIGLGLAWQLADRGINDIIVLEKGYIGVGSSGRAPVIINQHRTRKEMITLAKEGVKTLEELPTRLEFNPLFRQDGSINLASTQEEFDEIRKNVGLQNSLGVKTELLEPHEIKELIPPINEEKILGGAFIPSDGIPNPYAVLFGHVNALTKMGVEIRPFVEAKKIKVRSGETKGVTTKNSDINAPIIVDAAGGFAGEIAKTAGVKIPIQPMKREVLVTEMLKSSIDPAIISAHGNFYLAQMLRGEFACGSTAAKDGDPTLDSSLEFLRWISRRVVELIPQFAYVKIMRQWAGVIGVTPDKKPIIGGVNGVEGLYLACGLGDYGFTFFPAVTRLLAEDITSGETPDLLKPFSPERFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF57</accession>
    <name>A0A133VF57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05072">
        <property type="protein sequence ID" value="KXB05072"/>
        <property type="gene ID" value="AKJ48_00400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="245" mass="26416" checksum="2250280A36C0F6C6" modified="2016-07-06" version="1">MATELNYLKEPKLENPVTVAGLPGIANIGKLAVEYLINELESEKFAELYTDYFPGWVVRDSGLIEGLRVNFYEGGLEGSDRDFILVTADAQASSSTGQYKLSRKVLDVIADQAADMMVTMAAFLAPREDKSLVVGAATDAETAKLIEDHGVELLEGGRIVGMNGLLVSLAYEKGIEGCCLLGTTLGGVMDEDASKNVLSSLSDVLEFDLDLANFKDQVPDLPKLKPPKMKMPSVTGTGEDISYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF72</accession>
    <name>A0A133VF72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05080">
        <property type="protein sequence ID" value="KXB05080"/>
        <property type="gene ID" value="AKJ48_00365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.68"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="323"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="434" mass="45785" checksum="51CACD0E9BEE4982" modified="2016-07-06" version="1">MEIVNEAIASVNPSSAVHHRLRLEGEKLIVGNQEFDLSETGKIIVAGGGKASGKMAEALEEILGYKITEGVINIPEGTASKYNLGKIELVEAGHPLPTEGSVRGAEKIMGLVSDLDSQDLVICLLSGGGSALMTLPVDGVTLDELQETTQLLLKSGASIQEVNSVRKHLSKIKGGQLARAIHPARSITLIISDVVGDRLDTIASGPTYPDSTTYPDALEVIEKYGLTNQVPESVSKRLKSGVEGKAPETPKPEDECFSNAVHEIIASNSDAVKAAEAVGKSHGFNVSILTTKMQGEAREVGSELADIAKKVIEKREPVSRPTLLISGGETTVTVKGEGKGGRNQELTLSAAMNIAGLEKVTVASFSTDGVDGPTDAAGAVADGFTLERAEQSGLNPENYLERNDSYNFFKEIGELIIIGPTRTNVMDVTVLFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF78</accession>
    <name>A0A133VF78_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase AKJ48_00430</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05077">
        <property type="protein sequence ID" value="KXB05077"/>
        <property type="gene ID" value="AKJ48_00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="223" mass="24380" checksum="7C2FB401A3A76B99" modified="2016-07-06" version="1">MGSIKWLGQSGFEIKAGGKITLVDPFLTDNPKAPISPKDIKEADLICVTHDHMDHLGDSINLAKRTGATFVSIFELGNYAENQGVENTVRMNMGATLDVKGVKVSMVQAFHSSQRGSPCGFVLDFGEERIYHAGDTSLFGDMKLIGEYYEPEIACIPIGGYYTTGPREAAIATSLIKPEIVVPMHYGTFPEIQQDPNEFAKLVESSVESVEVNILEPGEKFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF79</accession>
    <name>A0A133VF79_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05064">
        <property type="protein sequence ID" value="KXB05064"/>
        <property type="gene ID" value="AKJ48_00350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.65"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="309" mass="34084" checksum="BB4BC46EFAFC610A" modified="2016-07-06" version="1">MTADIVGLGVCSIDEFVMVEEFCEPDDKIWVQDFEDHYGGVAANFCVGVARNGVKSGFMGSAGDDPDGHEIMKNFEDHNMDTDHFFLKEDTKSPRNIIVVNSHGDRQILQDPYMQKNILEPDEIIEDYVADAEIFHTDAVNIDTARKCMKIAKEAEKRVSFDLERHVAVYGLDEIKDLIEMTDILLPNQGGAQELTGKDDFEKAAKKMLDLGPEIVLISMGRRGSMLATSEGVQRIPIYKVDEVVDTTGAGDCFNAFFASNIHKGMNPEEAVDFATAAAGLSTTETGAQSAPTTKEVEEFLESEPERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF90</accession>
    <name>A0A133VF90_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="1">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="1">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name evidence="4" type="ORF">AKJ48_00415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TiaS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05074">
        <property type="protein sequence ID" value="KXB05074"/>
        <property type="gene ID" value="AKJ48_00415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.79"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF1743" evidence="3">
        <location>
            <begin position="142"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="273"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB05074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="429" mass="48457" checksum="98F06016DA6EDFBE" modified="2016-07-06" version="1">MLLHVGIDDTDSEKGMCTTYVGAVTIDRLKKQGIELIDCPKLIRLNPLWKHKTRGNCAISFTTDVSKNQIQKVKKIVLEGVEELAELNVKSTTPGVTFYQGERIPEKLRLFSKKVVQDVVTIEEAEKLADEIGAEIHKFGIGRGIIGALAAIGHPLEDDWTFELIAHRVKENWGTPRRVDEESVREMDEKTYPQTFDNLDPEAGEIHITPHTPCPILYGIRGETPEDVFEAQQIVKAEEPIERTILYKTNQGTDEHLKPAKIREAKPYHSIIIKGKVIKEPETITGGHVIFTIQDETGKADCAAYEPTRQFRDIVKQLEVEDIIKVYGGIKEKPELPLTINLEKLEIIELTSTKKKINPTCKKCGKRMKSAGKNKGYVCKKCKITLPEEAAEIIETPRKIKPGLHEVPTRARRHLAKPLIRVKSAERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA4</accession>
    <name>A0A133VFA4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05122">
        <property type="protein sequence ID" value="KXB05122"/>
        <property type="gene ID" value="AKJ48_00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="78" mass="8940" checksum="D3C11F5167BE43B7" modified="2016-07-06" version="1">MAKKRKKRGKFTSVSIPVELFDKVKEHVEKTGFPSVSSYVGYLLREVLVEAHETGEMPFAREDAEKIRERLRALGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFC7</accession>
    <name>A0A133VFC7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05127">
        <property type="protein sequence ID" value="KXB05127"/>
        <property type="gene ID" value="AKJ48_00250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="87" mass="9789" checksum="83B91D4D0BDF3292" modified="2016-07-06" version="1">MGMSHCGYVGTMGETVTLDSRGRLLLPAKIRGELGTQRFILKKKGGKLELEPLPAPESVKGKHKELIKVSLEELEETQERFIREGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFD1</accession>
    <name>A0A133VFD1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05114">
        <property type="protein sequence ID" value="KXB05114"/>
        <property type="gene ID" value="AKJ48_00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="SSF158372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF357" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="83" mass="9579" checksum="A39939C9C0D078E5" modified="2016-07-06" version="1">MLSDELQQEIERWTRKLDEKLPRLVARNGPGKEILENARAYRGDSQHFLQDDDLIKSFESLIWAWALIETGENLGHLKPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V975</accession>
    <name>A0A133V975_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ORF">AKJ48_04365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000096">
        <property type="protein sequence ID" value="KXB02969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02969">
        <property type="protein sequence ID" value="KXB02969"/>
        <property type="gene ID" value="AKJ48_04365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.945"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="76" mass="8934" checksum="0C62E97562BB3BCB" modified="2016-07-06" version="1">MVKTFRITGWFKHNDREQKFTKEMRAHSKDNVIERVYSDIGSRHGVKRNLIQIGKIEEIKPEEAEDPRIRALAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V991</accession>
    <name>A0A133V991_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000093">
        <property type="protein sequence ID" value="KXB03006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03006">
        <property type="protein sequence ID" value="KXB03006"/>
        <property type="gene ID" value="AKJ48_04335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="229" mass="26385" checksum="2142838368D9B52B" modified="2016-07-06" version="1">MLETLQKKKSTSILLALLEDSRHVRELQSEVGGSASTIGSRIREMKEKGLVSEETEKNWPYKKIIKLTNRGRDVAEVLSGLSGFARKRKITLMSFKERMKWPLVLVHRLKEVDGATRMQKLLFLLKRKFGVEVPYNFSPYKYGPFCKNLARDMACLVTAGLTDNTEESYILTSEGEEMAEEIFENLSKKVREAIGSLEKFNKMELRRLLNLVYTQFPEESKGSREIPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9C2</accession>
    <name>A0A133V9C2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000092">
        <property type="protein sequence ID" value="KXB03019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03019">
        <property type="protein sequence ID" value="KXB03019"/>
        <property type="gene ID" value="AKJ48_04300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="65" mass="7546" checksum="4C7E2CD76F397F66" modified="2016-07-06" version="1">MILLQRFSIVLQVDDPNYRTREVAELPVMGLVEPVMRRIDRTGARISVIQIEPNEQYYPQGGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9D5</accession>
    <name>A0A133V9D5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000093">
        <property type="protein sequence ID" value="KXB03007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03007">
        <property type="protein sequence ID" value="KXB03007"/>
        <property type="gene ID" value="AKJ48_04330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.934"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="206" mass="22945" checksum="B940B03A3471DD6E" modified="2016-07-06" version="1">MVKIRIEELKRELKEKIGKEGKVLGKGFLKVDSFLNHQVDPQLVDRIGMAIAEKYEDKEITKVVTAEAGGNIIAYTTARHLQSLLDSKVLAVYAKKEVPKTMENVMVAKVKSPTKGEVTDLAISGDYLKSGDRVVIADDFLFTGRTSEALTELVENAGATLIGYAFVISKRNFGGYERLRKHDRPIFALVEIVEMDSETGEIYFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-06-17" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9D8</accession>
    <name>A0A133V9D8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_04285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000091">
        <property type="protein sequence ID" value="KXB03041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03041">
        <property type="protein sequence ID" value="KXB03041"/>
        <property type="gene ID" value="AKJ48_04285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.924"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="170" mass="17990" checksum="FB56C910133407CE" modified="2016-07-06" version="1" fragment="single">MLSKMRERVKPWIESAARPFVNVGISPNQITLFGLLTGVLAAFLFGIGKPRLAGIAILACGFFDVIDGAVARLSSSVTKFGGFLDSVFDRVTDSAIFIGIMFGGLVSLWGHPLWFWPSLALAGSFLVSYTRARAEAAGTGKLAVGIAERAERLAILAIGGLLNLTGYAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9E8</accession>
    <name>A0A133V9E8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_04260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000089">
        <property type="protein sequence ID" value="KXB03072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03072">
        <property type="protein sequence ID" value="KXB03072"/>
        <property type="gene ID" value="AKJ48_04260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025931">
        <property type="entry name" value="TaqI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12950">
        <property type="entry name" value="TaqI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TaqI_C" evidence="8">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB03072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="357" mass="42224" checksum="55BCB25F44919A73" modified="2016-07-06" version="1">MLKYLKNNREKLEDRHRVKENIRKWHAIGVPQNLDIFEADEKILVPYRAKRASFAYDDQGYFNDGGDVRGIACKPNCKLDLKYILGLLNSKLLTFWYRIAGKEKGGMLEFFTTPLSRIPIRNIDFSNKEEKRKHDKIVKLVEDIQVLKKQERWISETFENLLKNYDMTEEEPLSYFFDPKDRSKLEKFSINVAETRKMDRGEAGVIDEYKVDLKENSVLISVRYKDKSNYREVLDLHFEDAALKEFFFLALKRNEGDKNYRSEKPVFETTMGDMTVPKSSETDLIDENVEAFQTMMEVLRKEFEKKVSKKWENSSVKKLDLTRIERAIEETDRNIDRVVYDLYGLTEEEVETVESHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9I1</accession>
    <name>A0A133V9I1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_04215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000086">
        <property type="protein sequence ID" value="KXB03118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03118">
        <property type="protein sequence ID" value="KXB03118"/>
        <property type="gene ID" value="AKJ48_04215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901663">
        <property type="term" value="P:quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB03118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="269" mass="29965" checksum="DDCDBA7923781882" modified="2016-07-06" version="1">MGVFPYLLGATIAYHSTNAFYFNYFLLGLIGIAISLGAVEIFNEYYDIKLGTDRVFNFNENLRLPSIKLGVISLVAALGIGLYLAIVRGWLILILLGVGVLAIVGYVGPPFRWSYRGFGELSIFLAYGPFMTLGSYYLQAQEIHTLPLITSLIIGFPILALSIINEVPDYHGDRLVGKKNVVVRIGRKNAVNLFGVMLALCFIILASSLILEKIPFFTLTIFTMIPLAYWNYRAAKKNYDDPKELTSAVRGTILLYLIIAILLIISFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9J8</accession>
    <name>A0A133V9J8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000086">
        <property type="protein sequence ID" value="KXB03116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03116">
        <property type="protein sequence ID" value="KXB03116"/>
        <property type="gene ID" value="AKJ48_04205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="94" mass="10734" checksum="609D345390BD4AEA" modified="2016-07-06" version="1">MNSFGRGDVVKFSKHAKVRMEKFGAVIFDTLKEDVFTTNEQGAEIIRLLQDGKSQSEIIEELTNEYDENHDEIASDVNNFLRELAEKEILIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9P5</accession>
    <name>A0A133V9P5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000085">
        <property type="protein sequence ID" value="KXB03135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03135">
        <property type="protein sequence ID" value="KXB03135"/>
        <property type="gene ID" value="AKJ48_04190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="214" mass="23145" checksum="EE3342403AD6EB8A" modified="2016-07-06" version="1">MREKTTLQGNKLKERLKIINWFGIGAGILMLALPFLGAWWQAEVGTGAMELAFSPFYYHVSFLEQTLTSPLVGYFILAAKLMIIIGGALMITGSMATDRWWGKKLMRFGAMKVFWFLIILIALLLLGAFFVNNFLPGILSGMVEGGGGVTTQFQVPYIAGSTTSTIQASGATISAPISTSLTSAFWIAVITAGLGIAARIYHGRLVKKLGVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9T8</accession>
    <name>A0A133V9T8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CbiA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000081">
        <property type="protein sequence ID" value="KXB03199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03199">
        <property type="protein sequence ID" value="KXB03199"/>
        <property type="gene ID" value="AKJ48_04120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.871"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="263" mass="27908" checksum="3669CBB0BDF18C87" modified="2016-07-06" version="1">MTINIAIAGKGGTGKTTIAGTLARLLARDGYNVLAVDADPDLNLDSVLGVDASDVAPIAKKDELITKRTGASPGGTSIPGVFKLNPKVNDITETYGVTAPDGVNLVVMGTVDEGGSGCMCPAGAFLRALMRHLVKRRDDAVILDMEAGIEHLGRGTADSVDSMLVVVEPGLKSVETALRIKNLAEDIGLNRIEAVANKIRTKEEADLIQERLEELGIPLLETIPFDETFVEADLLGRAPLDLGEDSEGIKAIRRIEKKITERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9W4</accession>
    <name>A0A133V9W4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000080">
        <property type="protein sequence ID" value="KXB03221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03221">
        <property type="protein sequence ID" value="KXB03221"/>
        <property type="gene ID" value="AKJ48_04100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="77" mass="9068" checksum="02DC3872D97E7445" modified="2016-07-06" version="1">MINEELLEILRYVYHANQGGMKPNYNKIRREFSIAPGTVRNRIRELEEKELVDIEKIGRSKVLEVTDKGRSLLLRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9X0</accession>
    <name>A0A133V9X0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TFIIB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_04145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000082">
        <property type="protein sequence ID" value="KXB03187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03187">
        <property type="protein sequence ID" value="KXB03187"/>
        <property type="gene ID" value="AKJ48_04145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB03187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="144" mass="16282" checksum="F263B9C51A2B3FE7" modified="2016-07-06" version="1" fragment="single">MNCPSCESTSVIFDEFQGEKICTRCGLVLTEKHPSLAPEWHTEPGSEAGRAEMTTGRDITRHDMGLGSEIGMGRDLSPRSRAKMRRLRKWHRRSQAVTYQEKSLRQALMDLDKLCEDLSLSKSVKAEVSSLYRKAKVAWVTPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA38</accession>
    <name>A0A133VA38_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000076">
        <property type="protein sequence ID" value="KXB03294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03294">
        <property type="protein sequence ID" value="KXB03294"/>
        <property type="gene ID" value="AKJ48_04025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.824"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_C" evidence="1">
        <location>
            <begin position="37"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="195" mass="21753" checksum="97E5A8BCF8A409B8" modified="2016-07-06" version="1" fragment="single">PETITITTTNPTDMMNFALYHYGNRSRQKTIGEAGMLDSARFRYALSQKFDVGMTNVEAYIIGEHGDSQVPLFSQVKVQGEEKTIKSEKEREEILNSLRKSAMSVIEDKGATIFGPARGVTLMIDSILNDKKKVYPCSVIPDGEYGLTDGSIGLPTKLGSNGVEEIVEWKISEEEKKMLTDSHEKILEICQEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA55</accession>
    <name>A0A133VA55_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease V</fullName>
            <ecNumber evidence="2">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Deoxyribonuclease V</fullName>
            <shortName evidence="2">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfi</name>
        <name evidence="3" type="ORF">AKJ48_04035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endonuclease V family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000076">
        <property type="protein sequence ID" value="KXB03295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03295">
        <property type="protein sequence ID" value="KXB03295"/>
        <property type="gene ID" value="AKJ48_04035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.826"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Interaction with target DNA" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="234" mass="25875" checksum="F4B27B45A6B99199" modified="2016-07-06" version="1">MMLEILKPPTTNLDELSKIQRKIAKQVIKEDKTGDINTIAGCDISFSKGNQACAASVLLQYPDLKELDHWTEEVEVDFPYIPTYLAFRELEPMLKVLDDVEADVYMIGAQGLAHPRRAGLASHLGAIIDKPTLGVAKNILCGEAKEPEPEKGSYTLLKDKGETIGAAVRTRANVKPVYVSIGHKVSLEKAIEIALKTAPKYKLPEPIRAAHNLATKAMKENPDRSLMKKLTDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAC6</accession>
    <name>A0A133VAC6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_03935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000072">
        <property type="protein sequence ID" value="KXB03386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03386">
        <property type="protein sequence ID" value="KXB03386"/>
        <property type="gene ID" value="AKJ48_03935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="181"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB03386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="350" mass="39474" checksum="6E06FA749426B28B" modified="2016-07-06" version="1">MSTGESTAKAPSKIKSAVKRKPTPEKKERKLSERLQDLKRLETRREEVREEMPSRWEELEEIGEARKAELARPLSERLADSFYKPLKAPAARMTGFFTGLEEDLFKAGMRIPVERYVALMLGVGIIVGIGGFFLSWLFLGFLLAIPVGLMSFMIALLLARRRPILRIQGRKNEIDQTLPYALRHISTQLSSGIGLAESMTSVSQADYGALSEEFERVLRDMRAGASMVDALTRMTERVDSEPLNRAVRQIQRTMKTGGNLSSTLSMMADETAFDMRMKLRDYTQSLNMMSMIYMFASAVIPALFIVLLIVMQFMGGASMPISLIAIIYLVALPFLLFYLVMIFKRMEPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAK4</accession>
    <name>A0A133VAK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug transporter MatE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000068">
        <property type="protein sequence ID" value="KXB03470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03470">
        <property type="protein sequence ID" value="KXB03470"/>
        <property type="gene ID" value="AKJ48_03855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="264" mass="28496" checksum="AFA59C1E02DBBCC6" modified="2016-07-06" version="1" fragment="single">MIKGKEKLDLTNGSIGKTLFHLSTPIIIINLLRMAYNIGDTFWLGQLSNEALAAIGFGFPLIFLFISLGMGVAVAGSVLVAQFEGGGNEKMVNFSASQTLTFSFIVSLIFGLIGFVAAEDLLILYGASEKVVSLGVSYLQIIFLGLSFMFGFAVFIALMRGYGDTRTPMFVMLFSIVLNVLLDPFLIFGWSFFPKLGIEGAAIATIFCRSLAFLIGLGMLLRGWKGLKISPSKMIPDLSFLQRLLKIGFPASIGATGRSVSVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB64</accession>
    <name>A0A133VB64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000061">
        <property type="protein sequence ID" value="KXB03692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03692">
        <property type="protein sequence ID" value="KXB03692"/>
        <property type="gene ID" value="AKJ48_03700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="153" mass="16629" checksum="593D222823BD99F4" modified="2016-07-06" version="1">MQVLQKLSDSDTDVSAWLLSQESTFPKDFASDYAIAVDGTLAGPYPAERVKIEQHEIPVEIGKGPALTLREDDVSIGREVKDLVKEAASKAGVELQIEATSRAEAKRLNPMKQNVSSAIFSIPIKHINTPGEVVNIKDLEDAVKVLESFAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB66</accession>
    <name>A0A133VB66_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000061">
        <property type="protein sequence ID" value="KXB03689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03689">
        <property type="protein sequence ID" value="KXB03689"/>
        <property type="gene ID" value="AKJ48_03685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.727"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="299"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB03689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="412" mass="46710" checksum="B4243C523F76C763" modified="2016-07-06" version="1">MDPSLCLKCKGGRMLCGRSKCPIQSRIDSLKSIKQKISKTSIFGASPPAIFVGRWGYPDVRVGPMVPPIRGEKGREFDDPKNWFGREIGEIIDLRTELVRSNFNANVRSASHPDKFLDLTQELAMASNPVDTEVELFKPPRVKLTYDGILSPVGPTGNLKEAKLAENPKVDKSVDYLVSDYDARASEALKELYEGGVDVYQSSRLLSAGLLGDKRDRKLVPTRWSITAVDSQLGNNLLSRVKQRQQISGIQLFSGEYLGNHFEILMLPDAYSFELIEMWRPHSVWMGGDSTQIVSDHEDWRSRSRYSPLGGGYYATRLPVLEHLDEARRQASVLAIREISSDYWAPLGVWVVRETARNALSQEPETFETIEEALSTMASRLKVQRKRWYTKSTLLKRLREQLKLEQFLEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBY0</accession>
    <name>A0A133VBY0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000055">
        <property type="protein sequence ID" value="KXB03953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03953">
        <property type="protein sequence ID" value="KXB03953"/>
        <property type="gene ID" value="AKJ48_03550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="95" mass="10961" checksum="74A8B5FA4AF0C655" modified="2016-07-06" version="1">MKVEDYVGKFSRILEMLDSRNWGKNFDKAEVAIAILHEVAKDRRMKLMSERSTSEEELATEKQMRFMGDLGIDFDEGITKSEASREIEKALNSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC58</accession>
    <name>A0A133VC58_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meth_synt_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000053">
        <property type="protein sequence ID" value="KXB04005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04005">
        <property type="protein sequence ID" value="KXB04005"/>
        <property type="gene ID" value="AKJ48_03475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="2">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="327" mass="37304" checksum="84399BDDBB3ACF4F" modified="2016-07-06" version="1">MKILTTNNGSYPRVGDKPGQQKLRQKYRQWEVDEISDEELEETYQEATREVIDEQVQAGLDIVTDGQLRWYDPISHFARKIKGCKINGLLRFFDTNFYFRQPVIKDKISWKEPIVKKEFTTAKEYSPVPVKPVVTGPYTMAKLSINEQYEEFSKLVRDFAKAISKEIDTLAKAGAEEIQVDEPAILKNPGEFKIFQEGVSKIIEEKNGARIALYTYFGDAAPLYGKLARLPIDILGLDFTYSPELPAKIARLGCEKGLGLGLIDGRNTKREDNQEILDTMRTILPNVGSERVYLNPSCGLDYLPRKVALEKLEHMVKIAEKAKEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC62</accession>
    <name>A0A133VC62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000052">
        <property type="protein sequence ID" value="KXB04038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04038">
        <property type="protein sequence ID" value="KXB04038"/>
        <property type="gene ID" value="AKJ48_03465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="66" mass="7532" checksum="885A4039F77653AB" modified="2016-07-06" version="1">MPKIKFGVTIDEELRKELDKIVGESEDLDSSRSEVVETILTAFFKSSVDHAKKARELIIKKRKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCB1</accession>
    <name>A0A133VCB1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000050">
        <property type="protein sequence ID" value="KXB04088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04088">
        <property type="protein sequence ID" value="KXB04088"/>
        <property type="gene ID" value="AKJ48_03405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="136" mass="14948" checksum="1BA32FD4D3F0634A" modified="2016-07-06" version="1">MYLLDNCGEAILDRLLLERIFGLGCDLSIAARSDPVQDDITLEEAEELNFSDLGELLPSGESIRVGPTRAPRKLRKRLDMADLILSKGQGNFEILSGHEGSFRGRLAYLLVAKCGSVSKALEVPRESKVIRFVESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCB3</accession>
    <name>A0A133VCB3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="2">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000051">
        <property type="protein sequence ID" value="KXB04057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04057">
        <property type="protein sequence ID" value="KXB04057"/>
        <property type="gene ID" value="AKJ48_03410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.644"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="PTHR11703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="243" mass="27610" checksum="6B2CE2BED4B9C7A0" modified="2016-07-06" version="1" fragment="single">LNNLIRDLVKEELVDVIVTTCGTLDHDLARSWSDYYHGDFNLDDVELHQEKINRIGNVLAPNESYGLILEEKMQPILNELYEEKQEFTARELAWEFGKRLGEDSILYWAQKNEIPVFVPGLMDGAFGSQLWLFWQEHRDFRVNPIQDEEELSEIVFNAEKSGGLIVGGGISKHHALWWNSFKDGLDYAVYITTAQEYDGSLSGAKPREAVSWGKIKEKASKVTVEGDATVLLPLIVGALIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCE0</accession>
    <name>A0A133VCE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000050">
        <property type="protein sequence ID" value="KXB04087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04087">
        <property type="protein sequence ID" value="KXB04087"/>
        <property type="gene ID" value="AKJ48_03395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="183"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="643" mass="72924" checksum="65A64479A2065FFA" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCG8</accession>
    <name>A0A133VCG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000049">
        <property type="protein sequence ID" value="KXB04117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04117">
        <property type="protein sequence ID" value="KXB04117"/>
        <property type="gene ID" value="AKJ48_03345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.605"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="186" mass="19784" checksum="8A43DD4B44330913" modified="2016-07-06" version="1" fragment="single">PTFHGAVKHAIGPRREIGLRTVFNVLGPLTNPAGARAQVMGVYDGGLTEKLARVLNELGCERAMIVHGLDGLDEISTFGKTKISELESGEIDTYTIKPEDYNIPPTTPKEIAGMDAEGNAEVLRKTLQGEKGPARDVIQLNAAAAILVSGKAENLEEGLELAGEAIDSGQALEKLNKLIEITNEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCH2</accession>
    <name>A0A133VCH2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">V-type ATP synthase subunit F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpF</name>
        <name evidence="7" type="ORF">AKJ48_03315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000048">
        <property type="protein sequence ID" value="KXB04142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04142">
        <property type="protein sequence ID" value="KXB04142"/>
        <property type="gene ID" value="AKJ48_03315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00312">
        <property type="entry name" value="ATP_synth_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022944">
        <property type="entry name" value="ATPase_V1-cplx_fsu_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="106" mass="11931" checksum="5C1873244FCBD5D3" modified="2016-07-06" version="1">MEIASITDPTTAIGLRLAGVREAHEVEDWREAEEIFEEMLGEREVGIIILTERLAQKMGEKVLELKEERGITPIIVEIPDKEGALPERAEAVREIVKRAVGVEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCH3</accession>
    <name>A0A133VCH3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpD</name>
        <name evidence="8" type="ORF">AKJ48_03330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000048">
        <property type="protein sequence ID" value="KXB04145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04145">
        <property type="protein sequence ID" value="KXB04145"/>
        <property type="gene ID" value="AKJ48_03330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.602"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="210" mass="24670" checksum="99D4A8C7E98C6591" modified="2016-07-06" version="1">MAAAARAVQPTRGELLKLRKRIDLAKRGHELLKEKRDALVTEFFDTLDRFEKVRGEMREKLENAFEKLIYSQIIMGSLDLRKAVEASMRDLEVDIGTRNIMGVKVPVVEPEDVRRKIMERGYSLHQSSPKLDEAAKEFESVLETILELAEIYKTVKLLAREIEKTKRRVNSLEHVLIPRIEESIEYIEMRLEELERENFFRLKRVKAEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCP4</accession>
    <name>A0A133VCP4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_03255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000046">
        <property type="protein sequence ID" value="KXB04223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04223">
        <property type="protein sequence ID" value="KXB04223"/>
        <property type="gene ID" value="AKJ48_03255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="220" mass="23500" checksum="536354E51ED4455C" modified="2016-07-06" version="1">MNASFMNYTFLGLAVVYVIGGALPSVTAVEALGMASIYAVTMGVVHLTVGVALAASSSSEKKPSLRSITLSILTFPAAFALIVALLFVGFNVTWPMELQSWVDMFANPAVFLMLLAAGYHMPVVDPRKYLPTISLVGFIRLLVCPLVTYGAIILAGVGQTVATTALILAAMPPGVFNIILAEKFDLDLELYSATIFYLTLISLFISVPLIVHFFMGVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCQ1</accession>
    <name>A0A133VCQ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">AKJ48_03270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000046">
        <property type="protein sequence ID" value="KXB04226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04226">
        <property type="protein sequence ID" value="KXB04226"/>
        <property type="gene ID" value="AKJ48_03270"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="Galkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="12">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB04226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="231" mass="23112" checksum="0B0C0DFA6773F728" modified="2016-07-06" version="1" fragment="single">GDGGGLELEILSDIPVGSGLGSSSAVTTATIAATSAVMGEVLGGEDVSELAFSAEKAVQGPASRTGVSVATQGGFARIQGREMENLEELPPLDIVIGYTGIYGSTAETVRRVKQLRESNSMITNPILETIGAITQAGIQAVKEGDFKKGGALMNANQNLLEGLGVSSEDLDRLITAARGSGALGSKLTGGGGGGSMIALSESDPQGIVEAIKGAGGQPIATEIGVEGLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCR2</accession>
    <name>A0A133VCR2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000046">
        <property type="protein sequence ID" value="KXB04225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04225">
        <property type="protein sequence ID" value="KXB04225"/>
        <property type="gene ID" value="AKJ48_03265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.586"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="444" mass="48627" checksum="F1DCEF1C6A31EA2C" modified="2016-07-06" version="1">MKGPKIVATPPGPKAREFMERDKKVMSPSLTRTAPLVGVEAEGVWVKDIDGNIFLDFSSGIAVTNIGHGDPRVMSAIREQAEKAIHINSCDFYTLPQVDLAEKLFEVTPGDFKKRIFFGNSGTEAVEAALKIAQWHTQNYYVISFIGGFHGRTMGSLQLTTPGVAARRHFKGMMPGAYHTPYPYCYRCPFKLEYPDCGLRCLEYIEDTVLDKLCPPEDASCLIVEPIQGAAGYIVPPDEFMPRLAKLCKEHGIILVADEVQTGFGRSGEWFACNHWDVKPDIITVSKAIASGLPCGAAIARAEIMDWESGAHENTLGGNPVVCSAALSVVDAIRSDDLVENSAKIGSYLLERFEEMAEDHPIIGDVRGKGLMIGLELVKDRESKEPAKKQRDELMRKAFKRGLILLGAGVSSLRLAPPLILTKEQADAGLRVFEDALSEVEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCR5</accession>
    <name>A0A133VCR5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000046">
        <property type="protein sequence ID" value="KXB04221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04221">
        <property type="protein sequence ID" value="KXB04221"/>
        <property type="gene ID" value="AKJ48_03245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="226"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="277" mass="31008" checksum="9E053E176AFE75EB" modified="2016-07-06" version="1">MKVKDVMTSDVKGVEIPGNREEALELLKELKVSALPAIKQGTNKLIGIIRLRDFFENPDESQLGMLVNRDIITITPDAPVEEAAKKMLENNVRRLPVIEDEKLSGIITVRDIVYRVIAEREIEAPALRYMQKSITLIWEDTPLKVAVEILGAAKARALPVIDSDGKLVGIIGDADIINVSEVETEEIKEQMGGRSESDSWTWDSEDRIYITKRSLKPSDKLVKDVMTKDVVTITKRTDATKCAKLLKEHQIEQVPVTSGRKLLGIVRDDDLLKVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCU4</accession>
    <name>A0A133VCU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000044">
        <property type="protein sequence ID" value="KXB04276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04276">
        <property type="protein sequence ID" value="KXB04276"/>
        <property type="gene ID" value="AKJ48_03170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="105" mass="12312" checksum="957621373E71CFF3" modified="2016-07-06" version="1">MSEYRFDGLPEFISRRTRVRLLELINGKLGSLSVIAERLGVSRWAVCKWFDPSEAHPNNQNTRKIIELAIRLDRIGTREILLDEALEYLELVRSRFNENYSANNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCV6</accession>
    <name>A0A133VCV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000043">
        <property type="protein sequence ID" value="KXB04288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04288">
        <property type="protein sequence ID" value="KXB04288"/>
        <property type="gene ID" value="AKJ48_03135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.562"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="46"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="308" mass="33589" checksum="3E4E74360A436D5D" modified="2016-07-06" version="1">MASSKLSHEGDLYNAGHRACPGCGAALACKYVTEATGPNTIMAMATGCMEVTSTPYPESAWGISWIHNIFENSAAVAAGIETAYKAFKKRGKKGYTDYDDINFIVLAGDGATFDIGIRSLSGMMERGHNVLYICYDNEAYMNTGIQRSGSTPLGASTTTSPPGKESFGEDIPKKDMPAIAAAHGCKYVATASIAYSEDFKNKIEKALKIDGPKYIQVTSPCPRGWRSDASKTIEIARLAVETGAYPLFEMEDGEITNVKKIKDRKPVEKYLELQGRFKHLFKMDGGEKIIQRIQEIADSNADRYGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCW5</accession>
    <name>A0A133VCW5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps4</name>
        <name evidence="8" type="ORF">AKJ48_03075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="4">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04296">
        <property type="protein sequence ID" value="KXB04296"/>
        <property type="gene ID" value="AKJ48_03075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_S4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_S4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="7">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="6">
        <location>
            <begin position="103"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="182" mass="21004" checksum="C203247C3339F80D" modified="2016-07-06" version="1">MGDPKRPRKQYSTPIRPWDRARMEKESHLINHYGLRSKKEVWKTETILRDFRRKARRLMAASGDQAVKEAQQMIVKLQKLGLLEEGSTLVDVLNLDIENVLDRRLQSIVYDKGLARTPKQARQLVVHGHIMVGDRCVTIPSYLTSIEEEAKVDLHPSAPFEKIEREEETPITPEPVEVGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCX9</accession>
    <name>A0A133VCX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000041">
        <property type="protein sequence ID" value="KXB04306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04306">
        <property type="protein sequence ID" value="KXB04306"/>
        <property type="gene ID" value="AKJ48_03045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="222" mass="25326" checksum="71D4874725864C4B" modified="2016-07-06" version="1">MRLDAFIKGLKNGAIKYVPRKGSDSRIDWSKYDRAQVNELRDMILFIRNVVDRAVVRLGLNEGEVRGRGRPPYPPGDLAKGVLIQQYFGVSNRVAEGFVDLFKEKLGIEESFSYKTLERAYDYPHVALILMEVFKMTQEPVKDKETKFAPDGTGIPNSIRGNWEKDSRSGEDADGFTKMISMFGITYHFVSAVRFPDNPYAHESPYFESLLEETTETYSSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCY2</accession>
    <name>A0A133VCY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="3">1.2.7.1</ecNumber>
            <ecNumber evidence="3">1.2.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.1" evidence="3"/>
    <dbReference type="EC" id="1.2.7.7" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000043">
        <property type="protein sequence ID" value="KXB04285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04285">
        <property type="protein sequence ID" value="KXB04285"/>
        <property type="gene ID" value="AKJ48_03120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.559"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043807">
        <property type="term" value="F:3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="178" mass="19162" checksum="7587AAA7F1DC7193" modified="2016-07-06" version="1">MKEIRIHGRGGQGSVTMAQMLAQAAFEDGKWAQGFPSFGVERLGAPVQAFTRIDDEKITDRSQIDTPDYVIVQDPTLIGLVNVLEGLREDGMVLLNSTSSPEELGLETEAEVLTVDATNIALEHLGKPIMNTALMGAFSSATGLIKKDSIIKVVKEKFSGEIGEKNASAINAAFERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD16</accession>
    <name>A0A133VD16_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000040">
        <property type="protein sequence ID" value="KXB04315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04315">
        <property type="protein sequence ID" value="KXB04315"/>
        <property type="gene ID" value="AKJ48_03000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="289" mass="33777" checksum="7FD9EC5A1449E0E3" modified="2016-07-06" version="1">MKLFILAVDALEYDFIESRDYAHLKQEQFFKVKIPRRCMTIFEDGNLSPWTPLIWKAILTGGISQRKPKPKPEQHWVGKLLKNKLLTRIRLARGINSLYRFLVSKLSKAPAIQEIRRGIPLQDQHTIMVRADNPAVINNPLEAPIEWGVPKALHSDFHPREIVRSHLEKFRKIKKETLSKVDRDWDLFLIYNKLLDIVGHLYWQKNHTVEKYYSIMDNFAGEIQRKLSDEAFMVIISDHGMRPLKGTKHQGGEHSHHAFVSFNHKLPIGKLSFTDIYPLLTEIMEEQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD24</accession>
    <name>A0A133VD24_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000040">
        <property type="protein sequence ID" value="KXB04317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04317">
        <property type="protein sequence ID" value="KXB04317"/>
        <property type="gene ID" value="AKJ48_03015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="131" mass="15511" checksum="4BEBB4E90D7B4916" modified="2016-07-06" version="1" fragment="single">MAEEIQPMEEEWDNLIILDACRYDYFERICDNYLSGNLKKVISPGSGTSEWLRRVFDNKKFDDIVYVSANPFINPRGSNLVEGFNGRECFYKVIDVWDRGWDDEEELKKLQSEAFINAKKFSLENQQERHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD26</accession>
    <name>A0A133VD26_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IU_nuc_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000041">
        <property type="protein sequence ID" value="KXB04304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04304">
        <property type="protein sequence ID" value="KXB04304"/>
        <property type="gene ID" value="AKJ48_03025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.539"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="331" mass="36001" checksum="967A0CC4D879C54D" modified="2016-07-06" version="1">MTKKVIIDVDTGIDDALGILLALNSPELDVVCITTVSGNLGVEEVTRNTLQVLELANSEKIPVAKGMNSPLSPDKKEEEIIIVNGKKVNGGEYFHGKNGLGDYKLPQPKTRPVKDHAVDFLIDKIRSNPHEITLITTAPLTNVGKAVMEDPKIARLVDEHIMMGGAYGLTPYGYGNVTPVSEFNVWADPIAANKVFSSKLSTIAVGLDVTQDPSVALTEDCLDHFTQETELNAFISSLISFHIKRGQGAAYPHDPIAVSAAIDREIFEIKDFLVKIETEGTIARGQTVVEKRPEAFVTMRGEVKTPNARICCGIDGGKFMNLFLNRLSKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD56</accession>
    <name>A0A133VD56_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">AKJ48_02900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000037">
        <property type="protein sequence ID" value="KXB04355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04355">
        <property type="protein sequence ID" value="KXB04355"/>
        <property type="gene ID" value="AKJ48_02900"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.485"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="216"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="31"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="351" mass="36987" checksum="C4BB3861A994B92A" modified="2016-07-06" version="1">MKNPTSGPEEDEFERAMREARPRIVAVGCGGAGGNTISRLMEDGISGVKTIAVNTDAQDLIHTNADSRILIGREVTGGLGAGGDPELGEVAATEDEDLLKDPLYEVDMSFITCGLGGGTGTGAGPIVADVSKRMGALTVGVLTLPFSVEGERRARNATVGLAEFREVLDSILIIPDDKLLEIVPDLSIEEAFRLADRLLADSIKGIIELVTMPGVMNLDFADIETILRDGGVSMMGIGESGTGDRAIDAAEEALESPLLEADLSKAGEALVSISGGPSMTLGEAERIADKVSEALAPDAQVNWGAQISEDLEEAIRVMIIIPGVHSPWARGIEARRKQKDVEEGLRGLKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD59</accession>
    <name>A0A133VD59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04361">
        <property type="protein sequence ID" value="KXB04361"/>
        <property type="gene ID" value="AKJ48_02825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="144" mass="15726" checksum="6C6C359CEE001038" modified="2016-07-06" version="1" fragment="single">MVVELNGGNAGREIAGWQIGYGNPKKMVKTVEKSGAGEEETIKTLVEEISRCEKVGAPVITPGRRGTQALRTRLLLLGEKNTPLRRVGFVHVQGLLEEHFLDSELPRIPDVGLSEAAERMGVGEKGAEKVELLRKIFLRVGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD99</accession>
    <name>A0A133VD99_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">AKJ48_02625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="LHYB01000032">
        <property type="protein sequence ID" value="KXB04423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04423">
        <property type="protein sequence ID" value="KXB04423"/>
        <property type="gene ID" value="AKJ48_02625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.423"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="60"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="125"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="206" mass="22749" checksum="401F22680D61455C" modified="2016-07-06" version="1">MNSSNEELRREVALCLHEVGGIQFGEFTLTSGESSPYYIDMRVVPSHPDLFDKFCELCAGMIQRKISRPIDKLAGVPTSGLPFSALVSHKLQLPMIFVRKGRKPHGRKKAVEGVLKKGDRVVAIDDVTTTGGSLKNAIEKIRMMGGIVEHVAVFVDREEGAREYLEKNSVQLHPCLKISELAKHLHESSALSKEGYSQIVAHLEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDE4</accession>
    <name>A0A133VDE4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04460">
        <property type="protein sequence ID" value="KXB04460"/>
        <property type="gene ID" value="AKJ48_02475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="235" mass="26372" checksum="3D03504471C0D33F" modified="2016-07-06" version="1">MEIVDDIHWVGAYFKEKGAVVNPFLLKGDKNLLIDVGPKPLADTLIENIQEILDPSEIDYVFLTHGAEYDHSGGLEEILGEATNASVNGHEIASMLIPMYGFDVEVESVKVGDSIDLGGKKLTFVEPPLSDTPDTLWAFEEENKVLFTSDTFGSFKQPGEEWELFLEDDLETALKEYHLWKFPWLKLASEKKLEEKIEEIKELEPEIIATYHGSLIKSSENVNKALNSVKKLAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDF2</accession>
    <name>A0A133VDF2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04478">
        <property type="protein sequence ID" value="KXB04478"/>
        <property type="gene ID" value="AKJ48_02395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="289" mass="33477" checksum="389C15C0166E3086" modified="2016-07-06" version="1">MRYLNEYSITAIISVLLVIGLFTIAVTEQSTQEDESNDLKKLLVTIDGSIKTLRLRGENSASDVLEGIQSQYNSFTSPYESDNFDNKPNLVKLNQEIDNKLAKLKQSPDKNSIRELRGMIQEMANELGVRLSFIYENSMIIILGVSFILSLIMSIIIKIGVNWEKIRGIRIELKNWQDKLRQAQLKSKKKEIRKLKLQQGEMSERQNTILMTDLKQAILYLIPFVLAWVWLSTIYQDWVVAWLPFNLPWPDFGIRLFSGTVASMGFLGWYLLSYFGFAQIWRRFLIPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDF3</accession>
    <name>A0A133VDF3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04470">
        <property type="protein sequence ID" value="KXB04470"/>
        <property type="gene ID" value="AKJ48_02525"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.368"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="149" mass="16898" checksum="F1A834822EFE96DD" modified="2016-07-06" version="1">MKGVLGQVNETQSTEKSDEEIIKILKENTNIAVVGCSRTEGKPAHEIPKFLKSKGYRVIPVNPFADEILGEKTYLSLEEVEEKIDVVEIFRPSEEAYEIVEEALETDAKVIWMQLGIKNEEAKKLAEENGLEVIQDKCMKIEYKRLVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDG2</accession>
    <name>A0A133VDG2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secY</name>
        <name evidence="15" type="ORF">AKJ48_02410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04480">
        <property type="protein sequence ID" value="KXB04480"/>
        <property type="gene ID" value="AKJ48_02410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.345"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="14">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXB04480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="453" mass="49172" checksum="18C0BA6D93C84A49" modified="2016-07-06" version="1">MDERSFRSKLYVLEPIIQRLPEVSVPKRHIGFKEKLMWSGIALIIFLIMTQVPLYGMTAQAQNWFGSLRYVLASRAGTLMQLGIGPIVTAGIVMQLLVGAKIINLDLSHPRDKALFTGTQKILAVLVGIFQASAFVMAGSFGPIATMGGLRILFLIIQLTLGVLVVLYLDELVSKYGFGSGISLFIAGGVSATVFWQAFNFTAPQGIIRGAIPNFISALASGSPGAISTAFFRTPAPNMMGVIATIIVFFIVIYAETMRVEVPLAYSRYGGLRGRYPIKFLYASVIPVILSLVLFTNFRIIGRILGGPVQGFVSTYMVSPQGLGAVTADPLRAVVYMLILMGSCMAFAWLWVQMTNMGPRDVAQQLKRSGMSIPGFRRDTRIMEKRLARYITPVTLLGGAFVGALAAGANFLGALSSGTGILLAVSIIYRLYQEIARGRVSEMFPAARRLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDI2</accession>
    <name>A0A133VDI2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">AKJ48_02370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="LHYB01000027">
        <property type="protein sequence ID" value="KXB04502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04502">
        <property type="protein sequence ID" value="KXB04502"/>
        <property type="gene ID" value="AKJ48_02370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.337"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="134"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB04502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="275" mass="29406" checksum="3EDB6B413A23F0B1" modified="2016-07-06" version="1">MIKAAVCGACGRMGRRIIKTISAQEDMKVVAAIEAPDSPQIGEDAGKTAGIGKIGVKVIGSDKLEEELKKSKADVLVDFTVAEAAVKNVEVGAKAGVAIVVGTTGFSEEQKNRMEKAIQNAEVPAIIAPNMSVGVNVFFKLAEQAAKLLKNYDVELVETHHDKKLDAPSGTAMKAAEIVAKSTDRELDKVAKFGRPKGELGERPKDEIGIHSVRAGDVTGEHELIFAGPSERLELIHRAQSKQAFVSGVIKAIQHIVKEGKPGEIQDMQDVLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDP3</accession>
    <name>A0A133VDP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04573">
        <property type="protein sequence ID" value="KXB04573"/>
        <property type="gene ID" value="AKJ48_02105"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.280"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="105" mass="11736" checksum="74BF1CFFFC64A229" modified="2016-07-06" version="1">MSAEDIEVIKDAESEAERKIKEAHEEAEKIVEKAEKKAQKLGADIKENAKKKAEEIVEERKEEAEKKAGEISKNTEKEITEIEKAAEERASEAVELVVKRVSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDP6</accession>
    <name>A0A133VDP6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04555">
        <property type="protein sequence ID" value="KXB04555"/>
        <property type="gene ID" value="AKJ48_02170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="151" mass="16526" checksum="D2A5793B8275FA97" modified="2016-07-06" version="1">MNNRGIGLLSIALVGALLVSGVLLSGTSLAQASGITDEADEPAAANESDEDWQCGMNGNRDHARSLEAKLDMLAERFDLTDEEVEEIEEKISTAIEEGTEPTEIREEVMSILEDYGVEIPEDLGPAKRQELRGHRRQNGECEGPFHESTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDR3</accession>
    <name>A0A133VDR3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenosine 5'-phosphosulfate reductase</fullName>
            <ecNumber evidence="5">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_02065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000021">
        <property type="protein sequence ID" value="KXB04596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04596">
        <property type="protein sequence ID" value="KXB04596"/>
        <property type="gene ID" value="AKJ48_02065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.271"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="9">
        <location>
            <begin position="41"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="270" mass="31845" checksum="0A4E74785D570DA4" modified="2016-07-06" version="1">MSKSKVELDDYQASEYAVEFEDKSPQEVLEWALDKFHPKISIACSLQAPDVTIIDMARKINPDARIFVVDTGRLYEEDHDLMSELEEKYGINFEVYSPEPEHVHDMIEKYGINSFYDSVALRFLCCQIRKVVPLMKSLKDLDAWITGLRREQWASRYNLKKIEIDHEHQGIVKINPLADWTWDQVWDYIKENEVPYNKLYDKGYKSIGCMPCTRPVEEDENPRAGRWWWEEKAPKECGMHCSVEFGGFEKYERAILEGQEEEEKSEKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDS5</accession>
    <name>A0A133VDS5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">AKJ48_02115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04581">
        <property type="protein sequence ID" value="KXB04581"/>
        <property type="gene ID" value="AKJ48_02115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="258" mass="29011" checksum="B0647F9D3A88997E" modified="2016-07-06" version="1">MESAKELISSSLREKQTITLVGSCVVNYKGRAGSVLPEGERIVILKPDGTLLVHQKEKRKPVNWNPPGCEARVRLGSEGLQVISRRSKPKESIIILFNELKLASSFELIDEEELQLVGSESDLVDMVMANPSLIEEGFKPMEREKTTRYGVIDLYGVDAEGNGVVVELKRSKINPPAVYQLGRYIEELEKKLDKKIRGIVAAPQITSSALELVRKQGLEYVKMEEPPSHAFEKVSFDKSQKKIKEFQLKSNEDSEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDS6</accession>
    <name>A0A133VDS6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04554">
        <property type="protein sequence ID" value="KXB04554"/>
        <property type="gene ID" value="AKJ48_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="61" mass="6697" checksum="B7A23F979C91FFDE" modified="2016-07-06" version="1">MLRLIAGVVFGGLAIFYFDGILFVTSSLLMSFDMFLNVITSRCKVNEVIGLDISGSMESQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDU0</accession>
    <name>A0A133VDU0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000021">
        <property type="protein sequence ID" value="KXB04595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04595">
        <property type="protein sequence ID" value="KXB04595"/>
        <property type="gene ID" value="AKJ48_02055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="83" mass="9127" checksum="1714DB390CA3021B" modified="2016-07-06" version="1">MSEKASEDKKSIDATGYVCPYPAMLALDALKKLPAGGVLEVTVDNPPSVENIPHKVESKGYKVEKVDEIGEKLWKITIRKQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDU7</accession>
    <name>A0A133VDU7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04626">
        <property type="protein sequence ID" value="KXB04626"/>
        <property type="gene ID" value="AKJ48_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="153" mass="16420" checksum="ABCC03F9C69B1143" modified="2016-07-06" version="1">MKLSSSAFENGKEIPSKYTCEGDDVSPPLSIEEVDPGTESLALVVDDPDAPGRVFDHWIIWNIPADADSIPEGVPPDEIVESLDGAIQGRNDFGAIGYRGPCPPEGPAHRYRFKLYALDTTLDLKPGSSKEELEAAVEGHVIGEVGLAGKYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDW0</accession>
    <name>A0A133VDW0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04630">
        <property type="protein sequence ID" value="KXB04630"/>
        <property type="gene ID" value="AKJ48_01970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="103" mass="11569" checksum="FF29695763423A70" modified="2016-07-06" version="1">MIMKGLISKLDIKKRVSILFIAVGFLVGLISGLGASAGLGAWEAFFLALFLFYVTSKLVPKVFDLEEEPLDSGTLSLFKLGLSSYWLVWLVSWVFFYNLVIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDW4</accession>
    <name>A0A133VDW4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04643">
        <property type="protein sequence ID" value="KXB04643"/>
        <property type="gene ID" value="AKJ48_01860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="87" mass="9711" checksum="B06FA22A7C8A030B" modified="2016-07-06" version="1">MSNKLQKKGKLAKSEEGELVLMNDDDQVFEADRIVIAIWDRCEGDISSSELSEEISEKSGEDQDKIQAAVVKIVDQLENANLLKTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE02</accession>
    <name>A0A133VE02_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH iclR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04669">
        <property type="protein sequence ID" value="KXB04669"/>
        <property type="gene ID" value="AKJ48_01805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="2">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="211" mass="23583" checksum="C4678DE2B5A2766A" modified="2016-07-06" version="1">MAARIAKFIPASMRSEIVQELINIVGIRPLSRKIGVNPKTVYNYKHGTAKPGDETMSRILAVMKEDQPHLLERHLERLQARFSNALEAPIELEEPPSREKPQPPSLPSVPPKEVQRPPSEPVARRPTPKTEVSLEEIFDKIGVSTSFDRMKAKNFLAGVRGEGLSVEDIVERSGLSRSAVEKYLQALISENLIEEGPPGTYTLSVRIREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE18</accession>
    <name>A0A133VE18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04675">
        <property type="protein sequence ID" value="KXB04675"/>
        <property type="gene ID" value="AKJ48_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="82" mass="9669" checksum="4A3815F416E5C1AC" modified="2016-07-06" version="1" fragment="single">DEGDISEDNLSEYEDRWRDIMGKRLKRYLKGKEVLLSLSDDELDDIAETLQEVDFEEISLTKMLKVLVKSHPKLLWKLKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE19</accession>
    <name>A0A133VE19_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04689">
        <property type="protein sequence ID" value="KXB04689"/>
        <property type="gene ID" value="AKJ48_01715"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.171"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="332" mass="36742" checksum="B1AB27F8C19F90DE" modified="2016-07-06" version="1">MDLVKYLKKRSEIVDKKIEELIPEDFDPQVLSDSTRHLIKAGGKRLRPVLALVSCEAVGGKEENAVEAAAALELLHTFTLIHDDIMDRDKYRRGVKTVHQTWDESTAIVAGDALFAKVFEAVVENAINQDLSADLVAELVDTVSKTSFEICQGQALDMEFEERRTVSESEYMSMINRKTGALFEASTKVGALLGGGDREEVEALAKYGRLAGVAFQIHDDILEISGDQETVGKPMGSDIREGKCTLIITHALTTVKDKDKESLLGVWGNEETTKEDIKKAIKILRESGSIDFAASKARDLVKKAKSKLEIIPDSEAREFLIELADFSIEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE22</accession>
    <name>A0A133VE22_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rps28e</name>
        <name evidence="4" type="ORF">AKJ48_01730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04692">
        <property type="protein sequence ID" value="KXB04692"/>
        <property type="gene ID" value="AKJ48_01730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.174"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="71" mass="7965" checksum="A9C664F75915C973" modified="2016-07-06" version="1">MPEEDQSIPVEVIEVRARTGATGEILQVKGRILEGSDEGRIITRNVKGPVREGDILMLREVEREAKEIRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE42</accession>
    <name>A0A133VE42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04718">
        <property type="protein sequence ID" value="KXB04718"/>
        <property type="gene ID" value="AKJ48_01670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="69" mass="8136" checksum="35470AB78A0574AF" modified="2016-07-06" version="1">MVINRQNKETKPVLYTRTLKLNCAYRFIRVKCVKDIAVTLKPDLITQVIYPYSMIVVEYQNVAESHDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE50</accession>
    <name>A0A133VE50_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04711">
        <property type="protein sequence ID" value="KXB04711"/>
        <property type="gene ID" value="AKJ48_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="82" mass="9214" checksum="7FDF79BA219E5663" modified="2016-07-06" version="1">MDGDTFEVARRIGKFNIIRLANVNAPSKNTKAGMKAMQVLRGMIGGKVVTIRPVGTSYNRIVAEVFADRKSVNKRMRERGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE51</accession>
    <name>A0A133VE51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04733">
        <property type="protein sequence ID" value="KXB04733"/>
        <property type="gene ID" value="AKJ48_01565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="63" mass="7061" checksum="E34B847A4A8E9AC6" modified="2016-07-06" version="1">MKIGFFVVSTELGGQLELGEEIHSEVREILSEISQKLKISGLIITSEMAEKRALPWKTCDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE57</accession>
    <name>A0A133VE57_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04738">
        <property type="protein sequence ID" value="KXB04738"/>
        <property type="gene ID" value="AKJ48_01600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.148"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031009">
        <property type="entry name" value="Tcm_partner"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04474">
        <property type="entry name" value="tcm_partner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="312" mass="36878" checksum="A3084CDA9E49184A" modified="2016-07-06" version="1">MKVKLHSKLKHKIISYYFSSGWRNVFKSGKFYSLYYVDLFAGDGYCECSDLDEELEGYLPDDLSKRKWEPPFFNLMKFANDSDVSLRCIFNDKETNKIESLVEEIEKKGYSRFLKAWFDGDANIVFKSALDIIRRPNRPSLFFLDPTNHKQLKFSTVEGIANFEDEKTGRKPELIINFMIHSILMSLKRGLKEEDVKSINNFLGTDFDREEILKITKDKSEKTHKSFLRIFLNNLGKLGYHCNWHLIKSVKTQSPIYYLIFATHRDDIQSWYAGVNFRVEKLEEEWVKKNYIIKTMSEAKKEGQRFLHDFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE64</accession>
    <name>A0A133VE64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_01580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04742">
        <property type="protein sequence ID" value="KXB04742"/>
        <property type="gene ID" value="AKJ48_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="355" mass="38386" checksum="0D0D414DDA0E1705" modified="2016-07-06" version="1">MFESIASKLRELAKPLLDTTFAVIIGLLIGALLMWLYGYDPWNAYYYLFKGGFGSLKGIFETLSFATPLMLTGITWLVGWKSGIFNIGAEGQMYMGAIGAVWIGGTVALPAGIHVAAATIVGMLFGLLWVLPVAALKVWRGTHEVVTTIMLNWIALFFVRYLIRYQVPMPGRAFRTVPAMETARFPMIFEGTTLTAAVFVAIAFCVGIFIFLWRTRLGYEFRLTGANPEAARYAGIDIRRIIFLNLLIGGLAAGLAGSTQVLGRPPVWGLYETMGGVFMLGYTGIGVAIIGRNHPIGAILAAFFYGGLLHGGTKMMAQAGVSGEMMVAIQGLIILAVALPAILPMIRGKIASWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE71</accession>
    <name>A0A133VE71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04739">
        <property type="protein sequence ID" value="KXB04739"/>
        <property type="gene ID" value="AKJ48_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="115" mass="13013" checksum="AEA7465EBE11E99E" modified="2016-07-06" version="1">MSEEYNQIVIMLERLKEELNSAIDECIEELTGETAEEREGRKIKILKAIYDAGGTVGLEKFHELGEEVGYDPRGLGGLFAWQGRGATLQKVEKLDKTEIVLTPKGREFLEEEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE84</accession>
    <name>A0A133VE84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04762">
        <property type="protein sequence ID" value="KXB04762"/>
        <property type="gene ID" value="AKJ48_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="189" mass="20880" checksum="99ED1D97D2038EBD" modified="2016-07-06" version="1">MAFLRLERLKLALWLLVIGSWGLGVIIGRWWSVNEFVIELSKVVQVVSPLQLGAWWHPIVFMILSVVGVFVLSQVFLGVGASVFLFARGMYDSTLIMQLEGTIGGWTLTNVPMSEVWIVSMLVLILAVNLPLCLWSGQLGAQRGVYVFYRLRGKTVDPDFGSKPFSKFLLILTASIAVGVVGAIIFSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VED5</accession>
    <name>A0A133VED5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04799">
        <property type="protein sequence ID" value="KXB04799"/>
        <property type="gene ID" value="AKJ48_01330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="147" mass="16705" checksum="E9E87C55BC1DB0E7" modified="2016-07-06" version="1">MTRKPRVFLDTNTLVSGIVFAGNERKLLDAIIDGKIEWVLSTNVTDEANAVLEKKFPKHAVLFTLFLNLVRHEKTPKSKYKNSVKQYSKLVNKKDAPILAAAIEGNVDYLITGDKKLRDLKQVKNTKIIRTRKLLKLEKLAEESANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEF0</accession>
    <name>A0A133VEF0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04833">
        <property type="protein sequence ID" value="KXB04833"/>
        <property type="gene ID" value="AKJ48_01300"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.910"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="358" mass="39327" checksum="1FB7592631712449" modified="2016-07-06" version="1">MIFICSSRGILVAKRAHLRFFERWLSVWVALCIIIGVVLGEVFPGLASVSWDVQYAHVSIPIAVLLFFMIYPIMVQIDFGKVVRAGRTPKPVGTTLFVNWLIKPFTMAFFAWLFMSIIWSPFISPGLASEFKAGMILLGVAPCTAMVLVWSYLSKGNMGHTLVMVAINSLIMLFLYAPLGGFLLGVSGIPIPWETIVFAVGIYVGLPLVAGYFTRQRLLKKGQRWFREFTSDLHYVSIVALLVTLVVLFTSQGKTILAQPLIIGMIALPLTIQIFLIFLIGYGISKKIGLSYEDAAPTAQIGASNHFEVAIAVAITLFGINSGAALATVVGVLIEVPIMLTLVKICLRTQHWFPRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEI9</accession>
    <name>A0A133VEI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04859">
        <property type="protein sequence ID" value="KXB04859"/>
        <property type="gene ID" value="AKJ48_01195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="119" mass="13230" checksum="CD1896FF2F062C3C" modified="2016-07-06" version="1">MGHTEAKVKIYESDPSKAEELELLVDTGSTYSWIPAETLEELRVERKKTRRFETIEGKKITRDVGEIILECLGESATNMVVFAKDGDKPVLGVVTLELLGLEVDPTTNKLRKAEALLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEJ8</accession>
    <name>A0A133VEJ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04827">
        <property type="protein sequence ID" value="KXB04827"/>
        <property type="gene ID" value="AKJ48_01295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="93" mass="10791" checksum="F519695B5DA50D68" modified="2016-07-06" version="1">MTEDQLRLLKCVANETRLQILKLLAKEERCVCEIMGELDKEQSLISHHLKSLRECGLITKRRRGKKILYKISDPSLVKFTSKAEELGKKFCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEK6</accession>
    <name>A0A133VEK6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04880">
        <property type="protein sequence ID" value="KXB04880"/>
        <property type="gene ID" value="AKJ48_01130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="116" mass="13585" checksum="F476F39294BA495D" modified="2016-07-06" version="1">MVLIIPSRKVRNHLTSENIIYFVSDKKRNEDEDWITDKFGGKKIADANIELERKIDLSTHKNLEAILYMWLKTYVEHSGFENTYQWIGDIKKSNDGETPEELYLYEIILSNNASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEL5</accession>
    <name>A0A133VEL5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04857">
        <property type="protein sequence ID" value="KXB04857"/>
        <property type="gene ID" value="AKJ48_01160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="165" mass="19048" checksum="21EFA2C294182E30" modified="2016-07-06" version="1" fragment="single">MKVKLLSRTLDPEHLIGIAARSCWTQEGASKLNPNPKKLEKLAKREVERGHESILEHAKFTFSIEGISRACSHQLVRHRIASYSQQSQRAVKIEEPDYVTPPQIQANSKLEEKYEQIMNQAWKNYRELLDSKIPREDARFVLPNAAKTNIVMTMNARSLLHFLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEL6</accession>
    <name>A0A133VEL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04871">
        <property type="protein sequence ID" value="KXB04871"/>
        <property type="gene ID" value="AKJ48_01085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="285" mass="32430" checksum="5B9B9FD0C1320DC9" modified="2016-07-06" version="1">MSFIEFVRNTRTEFEDFLQQKMPTQEDGEPIWKSLQGGKRLRPLLCILSYRARGGTAQDYEEALDVATAVELGHCASLYHNDIIDKDLERRGNPALWVENGIPRAMMVGHEAISWGFQISLDHGDDIAETFLGAWDQSLRGELREISARENQKGSTSTRLDIITKKTGGLFSAASKVGSQAADASQDLQKLMEEYGLMIGMAYQFADDLFELRNGKNEDLLKMLEDSGELKNATLEEYLEEEMRDVIKKSEKLSHNPRIPKSEFKEFLSEAPEFFVNQMLRESKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEN1</accession>
    <name>A0A133VEN1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">htpX</name>
        <name evidence="13" type="ORF">AKJ48_01035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04903">
        <property type="protein sequence ID" value="KXB04903"/>
        <property type="gene ID" value="AKJ48_01035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.715"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="12">
        <location>
            <begin position="71"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB04903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="292" mass="31834" checksum="CD9A3C3E028B5E93" modified="2016-07-06" version="1">MGAHIRTVCLLVLLTVLLVGIGYAVGFFLGIPVTYTLTIAFGFAILLNIVTYWYSHKWVLKMYKAKIVSEKEEPKLHQMIGRLATYADLPKPKVAITKSDTPNAFATGRNPSHAVIAVTKGAKNLLSEEELEGVLSHEMAHIKNRDMLVNTMAAMIAGAIAYIGFAGRFGLFFGGGRRGGGILALIAIILLPIAAILVRFSISRTREYGADREGANISGKPLALASGLKTIENSVKNKVKFGRRPEKGNPATSHLFIVNPFRGSSLTELFSTHPATEKRIERLEKIAADRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEN2</accession>
    <name>A0A133VEN2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04885">
        <property type="protein sequence ID" value="KXB04885"/>
        <property type="gene ID" value="AKJ48_01145"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.788"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="216" mass="24464" checksum="0359BDEF96AC5062" modified="2016-07-06" version="1">MTRWGMVIDLRKCAGCQTCTISCKIENFLPPDVKWGRVEDYEEGEYPDVMRRFLPMSCMHCEEPACKEVCPSGATDQRDDGIVTIDYDTCIGCKYCMTACPYEARSYMEEWESEIKKLRPRPIPKEAQSESQQFARGTVTKCTFCAHRIDKADEANKEPGEDPEVTPACVNTCTGGARYFGDLDDPNSDVSQLAKSDRAFRLHEEIGTSPSVYYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEN9</accession>
    <name>A0A133VEN9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04906">
        <property type="protein sequence ID" value="KXB04906"/>
        <property type="gene ID" value="AKJ48_01050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.718"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="52"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="385" mass="42379" checksum="3627FE745535336E" modified="2016-07-06" version="1">MMMAEKVFSNGTILAGEELEAVKGYLTVRDGVVNEIGEGQPPKRGIDLHRGFIIPPFVNAHTHLADSVIKDIYAGRKQEDVVGARSEKFVALNSSSEEAKIKAIESSLHDMIRTGTSAHCDFRESGKAGIHLMRKAKESGVKSILLSRPEKQDEVKDLLTISDGIGLPSLNSFSDEEIRKISALTAKAKKFFSIHVAEVRNAQKSSIENTGKTEIQRALDFDPSFLIHGTWASDEDLTLMKKKGVPLVICGRANHLLSVGAPPLNQALEKGVEIWIGTDNVTACQPDMFRELSFDWALLRKNNSQVGSEEARALLKSATVNSSRGLRLPFGALEKGNKAVFTILGRKNNLINLKDPYVGIVNRARADNIRMVFCPDGEVRKFWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ0</accession>
    <name>A0A133VEQ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04884">
        <property type="protein sequence ID" value="KXB04884"/>
        <property type="gene ID" value="AKJ48_01155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="113" mass="12720" checksum="F3A1E32C399C2C72" modified="2016-07-06" version="1">MSENQKKEDPPTDLQILVLAGGYSERFGKEKVISSIPHIESKYLVVATCDCPKISPKVLKMIYEKAVGHDGSVPIWPNEYIEPLQATYQVLSVIGLFYFTYTHSHISQSPHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ1</accession>
    <name>A0A133VEQ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">16S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_01045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04905">
        <property type="protein sequence ID" value="KXB04905"/>
        <property type="gene ID" value="AKJ48_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:18S rRNA aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="PTHR20426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RLI" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Ribo_biogen_C" evidence="8">
        <location>
            <begin position="41"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="171" mass="19384" checksum="F28C2FE1FFF58124" modified="2016-07-06" version="1">MKLFVYNALECDPEKCTAIRLEKNDKVEAFYQIRKIPREVILLDPLTEKAFSPADEEIVEQHGLLAVDCSWKNIDSIGEIRTGRESRSLPYLVAANPTHYGRPTILSTVESLAAALCILGHREKAESLLEGFKWGHTFFELNEEPLEAYSKAEDSAEIVRIQEEFLPGEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VES0</accession>
    <name>A0A133VES0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formylmethanofuran dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04948">
        <property type="protein sequence ID" value="KXB04948"/>
        <property type="gene ID" value="AKJ48_00795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018493">
        <property type="term" value="F:formylmethanofuran dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02761">
        <property type="entry name" value="MopB_FmdB-FwdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016457">
        <property type="entry name" value="Formylmethanofuran_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005646">
        <property type="entry name" value="FwdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03129">
        <property type="entry name" value="one_C_dehyd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="1">
        <location>
            <begin position="49"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="424" mass="46176" checksum="C11EAC6C306B8001" modified="2016-07-06" version="1">MSLKENVICTFCGCLCDDINVEVEKEGITNLKRACANGRSKILGYDENRVESPQIRKNGELTKVSLEEAVEKTAEILKESKFPLIYGLSSTETDAQKLAVELAEVIGATIDNTASVCHGPTILGIQNSGAPECTLGEVKNRADLIIFWGCNPAEAHTRHPTRYSVIPEGMFVKGRKDREVINVDVRETNTSKMSDTFIRVEPGKDYELLSALRASVKGHDIGDVAGVSSDTIKELTEKMKGCKFGVIYFGLGLSLSLGMHMNVLAALELVRDLNDYTKFSINPMRGHFNVTGANKVMTWLTGYPFAVNFSRGYPIYGPGEFTALDVLRRGECDSALIIASDPIAHFPAQASKHLEKIPTIVIDPKVNATTSVADVVIPSAIAGIECGGTAYRMDGIPLELKPFIESDVSSDKEILAKIIEKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VET1</accession>
    <name>A0A133VET1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04946">
        <property type="protein sequence ID" value="KXB04946"/>
        <property type="gene ID" value="AKJ48_00755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019385">
        <property type="term" value="P:methanogenesis, from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003704">
        <property type="entry name" value="CO_DH_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02552">
        <property type="entry name" value="CO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="155" mass="17670" checksum="57F8880CA04D5A61" modified="2016-07-06" version="1">MYGETCGRKKASELKPKALGKMLARAENVLFILASEVDRYPSDILKEIVEKSNATVYKTEAAGTEKVDIDTDARYGLMEIVDRLCNEMGEEYDYIVLAGVPYHIETRVLSGLRSYGMKKVVTLNWRHQQYADLSFPNMPDAERWKKSLNEIAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VET2</accession>
    <name>A0A133VET2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F420_ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_00855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04959">
        <property type="protein sequence ID" value="KXB04959"/>
        <property type="gene ID" value="AKJ48_00855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043773">
        <property type="term" value="F:coenzyme F420-0 gamma-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="250" mass="27136" checksum="42FF0664856155AE" modified="2016-07-06" version="1">MKIIGLKTPVIKPRDDLIEIVLEAVNKNEDLRDGDVLIIASSAISTANGYVRKLSDVEATERARKLGEKSGLDEKFVEIVIHKADKILSVGENCLLTLKNGMLRINAGVDSSNAPPNHVLVMPDNPDREAEEILQKINNETGKKIGVVISDSHIQPLRLGTTGLAVGVAGIEATIDCRGKTDLYERPLTMTFRAVADQLASAAQLVMGETDDQVPAVLIRGVKVNLTGKSETPKISPKRDIYADLLEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VET7</accession>
    <name>A0A133VET7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04924">
        <property type="protein sequence ID" value="KXB04924"/>
        <property type="gene ID" value="AKJ48_00915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="161" mass="16863" checksum="C323A878F42DC195" modified="2016-07-06" version="1">MSGKTIGTLILIAVIGVAGGVATAYFLRSSSEGGGNAPNYEAVATVSRVDDGDTIGVNITEVTVLHDGVSEGEDTIRFAGIDTEETGLNSHATYLHSELEGVSESEYKQTEYYQHAMSAKSLVENLCSGLTVYLDIDDQAEGHGPYHNSTVAISTVGITMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEU7</accession>
    <name>A0A133VEU7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ48_00865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04934">
        <property type="protein sequence ID" value="KXB04934"/>
        <property type="gene ID" value="AKJ48_00865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.622"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB04934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="637" mass="68400" checksum="552422A74C39C4EC" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEV3</accession>
    <name>A0A133VEV3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ORF">AKJ48_00585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04978">
        <property type="protein sequence ID" value="KXB04978"/>
        <property type="gene ID" value="AKJ48_00585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.382"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="184" mass="20177" checksum="F40127AC74FD7F52" modified="2016-07-06" version="1">MRLVVGITGCSGVVYGVRFLEACRDLDVETDLIVSPAAEEIMSFEVDEDLEDVRSLAARSYDYDELDASISSGSTRTDGMAIIPCSMKTLGAVASGVSDNLVTRSADVTLKEGRPLVVVPRETPLNLIHLENMGKLDRAGATILPAMPGFYHDPQTIDDLIDFIVGRILDQFDVEHQLYQRWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX1</accession>
    <name>A0A133VEX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho 3-hexuloisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. PHI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04991">
        <property type="protein sequence ID" value="KXB04991"/>
        <property type="gene ID" value="AKJ48_00665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.398"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05005">
        <property type="entry name" value="SIS_PHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017552">
        <property type="entry name" value="PHI/rmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43443">
        <property type="entry name" value="PTHR43443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03127">
        <property type="entry name" value="RuMP_HxlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="36"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="201" mass="21743" checksum="FE1F7F5885752C9D" modified="2016-07-06" version="1">MIDGGRLKEVQEAMDLINNHVEDVAEKLSEEEVNNFVNTLLGSKRVFLIGAGRSGLIARAFAMRLMHLDLDVHVIGETITPGVEKDDLFIGVSGSGETTLVVSAAKAAREIGAKIAVITSYPDSILGKLADQVVTVPGRVEPAKTRDYMDRQISGKYESLTPLGTLFEATALIFLDGVIAGLMSKMGKKEEDLNRFHATIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEY3</accession>
    <name>A0A133VEY3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05001">
        <property type="protein sequence ID" value="KXB05001"/>
        <property type="gene ID" value="AKJ48_00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="82" mass="9774" checksum="C3A8865EEBECD256" modified="2016-07-06" version="1">MEKPELDWIVEKASELLSDKVEDSPLKEEDVDLAFEIFADPRLKKVSKSFDSEEEYTKAVNYVRVKLHEIYKKLNEEHWSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEY4</accession>
    <name>A0A133VEY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04990">
        <property type="protein sequence ID" value="KXB04990"/>
        <property type="gene ID" value="AKJ48_00655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.396"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="200" mass="23085" checksum="6E1A79FCD39A9A35" modified="2016-07-06" version="1">MAKKYEDHGIVLDFMPSGRTDERKPAHLREPLAQLLGKSFFTLLEAVPNPKVKLKLHDEVYIGKGDREKIERVKRRIGYKELTAASKAELPVIIEKLIEGDPERFLKFFNEAGPVTSRYHQLELIPGIGKKLMWGIIEAREEKPFEDFEDLNNRVKSLPRPKRIIAKRIEKELKGEDKYRIFVRRPKQPSRGGGSSRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEY9</accession>
    <name>A0A133VEY9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycos_transf_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05006">
        <property type="protein sequence ID" value="KXB05006"/>
        <property type="gene ID" value="AKJ48_00620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="255"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="456" mass="51615" checksum="E0A4075BCB44C0F5" modified="2016-07-06" version="1">MRERISLCVGTQTPLARFKSSLGELYDKYGQVPEPLPLDMLAEGEDYVYAPGGVTRLLPPLLRTLYEQGFIRKPHWVALNPMGPETVLAEGMILHSIELRPRASAKYGRFKEAIWKNVHGVEHGLVPRESFSGYALYNWLTAQEMLDLHSQFDFDLFYIHDFQLLQIGSMLGPTAPKIFRWHIPIDVERMLPEWQDFVLNYLNNYDAVIVSCKRYKENLQKAGFQGRLYQVYPHLDPDTYGTPSRSRVRNFCYKYDIEDDDKIALVVARLDPMKGQNAAVKGIAQIARRYPNLKLLLVGDGSFSSSAKGGLGLPKGLRWKQELDNLASSLNISDKVTFTGFISDEELESAFTRADIVILPSVLEGFGLIVLEAWQYQKPVIVSSEAGVAELVNEGENGFIFDPKNPKELAEKIDSLLSNPENAEEIGREGYETVKKCYLGKIAKRLRGIMEEVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEZ0</accession>
    <name>A0A133VEZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05005">
        <property type="protein sequence ID" value="KXB05005"/>
        <property type="gene ID" value="AKJ48_00745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="77" mass="8769" checksum="222A44D665678A86" modified="2016-07-06" version="1" fragment="single">AEDRELEAIIVSEETRSRAEEINEIRESNDLEALDIIEIPWVLAEDGKPISSIRIRYGEMDEHGEIKKTEEDISDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF14</accession>
    <name>A0A133VF14_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_00545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05038">
        <property type="protein sequence ID" value="KXB05038"/>
        <property type="gene ID" value="AKJ48_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB05038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="110" mass="11729" checksum="13CB91438CE3260D" modified="2016-07-06" version="1">MLILSYFLFLALAAAVFSVGVYGLFTRRNMLRMLLSAEVMFNSALLTLLALAATSEPLGGRVLALIAIGTAAAEIGVMISIGILFFRRTGEIDVYKLSEGTRGGSKESHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF18</accession>
    <name>A0A133VF18_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05032">
        <property type="protein sequence ID" value="KXB05032"/>
        <property type="gene ID" value="AKJ48_00500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="122" mass="12941" checksum="6F39AA06ABCDE264" modified="2016-07-06" version="1">MGVVAGLQVMKVKKLAISVERLPSQVSASCGATRKDGTPCASSARWAIGLDEDIELLACGTHGRYSWNRTEDINDLGDLEKRGFCLKKVEELAENRTIITASGLAGDEFGVSDKVALAEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF20</accession>
    <name>A0A133VF20_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05039">
        <property type="protein sequence ID" value="KXB05039"/>
        <property type="gene ID" value="AKJ48_00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="138" mass="15259" checksum="CC3B51F0CC08F3A1" modified="2016-07-06" version="1">MLNPLGPPVEGVSYSVGVILFILVEGLAYSLVVAYFIHRFVKEGARFTLDLFNGLETGFIDILYHKSIPRAVTSTFRNLFEGFELPVVDKGFNEKLVDKILSAGELFGKIQTERINHYLIIFGLGILLSLALVLGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF22</accession>
    <name>A0A133VF22_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05035">
        <property type="protein sequence ID" value="KXB05035"/>
        <property type="gene ID" value="AKJ48_00515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="212" mass="23952" checksum="A41141B20768C133" modified="2016-07-06" version="1">MQPHDSEGSQESTCGFGSQLFNRRIDNLREGFPITFPVVAFFDESKESIITSTAPAFSQKVDNIEANPKVSILFNASDTVLVKGDGKIHDEDFEENALYGMRLITEEPETPKKSAYMKLVERLNTWYGKLLLDWYKIASGENAGCEVLANSPDIPVSFGLVKNALGERTLNRTYWRATELEWLESRSNPYLETKSMFRSERFDSIFPVGASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF33</accession>
    <name>A0A133VF33_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proton_antipo_M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_00555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05040">
        <property type="protein sequence ID" value="KXB05040"/>
        <property type="gene ID" value="AKJ48_00555"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.256"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="127"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB05040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="472" mass="50433" checksum="601DA1A5604C2353" modified="2016-07-06" version="1">MIESAFTLICFILTVAGLISPTLDFTILKGKKIVSPYITLLGLGASGIILLFLSIVKFGQSAVPIYGGMLQVGFYEMFLSLIITIGAILVTMASLSGVKYWPTSPSFYSLLSLGVLGSYFLISIGDFVLFIGAWALVSVISYVMVGLKKNRASAEGAAKYALMGILASVLLLYGIAILYGMTGDTSLSIISTLAGTRELMLVLSLVFLVSAFGFKIGIVPFHGWLPDVYGKVHPALIAFLTGVVTVGVVGLIVKILFPLAAIVGGQWPILIGLLSIFTMTFGNIVALIQRNFQRMMAYSSIAHMGYIFVGAAAALSAGRAVGLQGIGLHLASYAFAKIGLFIFLAYILRKGLSVKLDDLKGLGRSMPIVSVAIGIILLNLIGIPPLLGFWSKFYLFSAGIEVTPWLALIAIINSGVSVGYYIQPIRYMFFEKGSNPPNERLKDSEPMTILIASILLIAGGLTLQPIVPYLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF51</accession>
    <name>A0A133VF51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05034">
        <property type="protein sequence ID" value="KXB05034"/>
        <property type="gene ID" value="AKJ48_00510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="86" mass="9281" checksum="AF445CEDFB34091F" modified="2016-07-06" version="1">MIGGLSVGVDSGLELEVGCGLLEERKIVGRSERSWDWKGKGIESGQDCELFALGQWGRVNSLSQSPNSITCPYCLISDSRSGDCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF56</accession>
    <name>A0A133VF56_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argS</name>
        <name evidence="12" type="ORF">AKJ48_00410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05073">
        <property type="protein sequence ID" value="KXB05073"/>
        <property type="gene ID" value="AKJ48_00410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.78"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="11">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="499"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB05073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="614" mass="69052" checksum="DC965D9DBBD90D51" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF81</accession>
    <name>A0A133VF81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05108">
        <property type="protein sequence ID" value="KXB05108"/>
        <property type="gene ID" value="AKJ48_00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026453">
        <property type="entry name" value="PGF_pre_PGF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04213">
        <property type="entry name" value="PGF_pre_PGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="182" mass="21035" checksum="C3414FF20430080E" modified="2016-07-06" version="1">MNGKWQELPTTLVDESPSYLYYEAQSPGFSIFAISAEGVPSPSPGLPLALYATVAAGFGTAGLSLFYWFRRRRIKPSVSLEDIKQTVMGREEKTEVDEEEKKAKGEYGRPSEEELAEKQKKDLKRLEEIVKEKKEGKPSETKKRKLTPLMKQYEEETGKNARRKDGELTKAYKKWRRKRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF96</accession>
    <name>A0A133VF96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05111">
        <property type="protein sequence ID" value="KXB05111"/>
        <property type="gene ID" value="AKJ48_00140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="348" mass="40139" checksum="8B3AE4DCF7D6303B" modified="2016-07-06" version="1">MGWEEALDQYGGLVEERLEDFLSELVEDRKDYHPFMSDLYSKIREYVLRKGKRLASCSTLLTYKGYTGELDDRILNACIGVELFRHSILIHDDLVDQDEYRRGGPALHRLFSDEYDERFSEGTAIFMGDAMYALALQAFRNPRFTEEKISELLRLFEKGYREVNESQVLDLLFESKEPDVEEWQIMASRRAATLFRTTILAGAIPAEALEEDRNLLEKAATHVGYAFDIQDDIIDIFASEEQYRRPPGGDLRHGKKPLHMVHALKLAGEEDLKTLRGLVGKESLTREELESTREIIRKSGALEAAKNESKRHAETAKELIAKTRLDKETKEFLSSLISYIEQSLDWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFE0</accession>
    <name>A0A133VFE0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_00175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05137">
        <property type="protein sequence ID" value="KXB05137"/>
        <property type="gene ID" value="AKJ48_00175"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.31"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006399">
        <property type="entry name" value="Ribfl_synth_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01506">
        <property type="entry name" value="ribC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB05137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="138" mass="14997" checksum="77B41C9A53E70015" modified="2016-07-06" version="1">MASAAIDELKQLCSVKFERKTVPGIKNLPVAVKRLLDEGCDIVMAFGMPGAEPIDKQCAHEASTGLIQAGLGAGKHVIEVFVFEDEADSDKELAELADQRAREHARNVYRLLFKPEELEKLAGTGQREGGPDAGPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V927</accession>
    <name>A0A133V927_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000097">
        <property type="protein sequence ID" value="KXB02958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02958">
        <property type="protein sequence ID" value="KXB02958"/>
        <property type="gene ID" value="AKJ48_04375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.947"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB02958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="99" mass="11273" checksum="7738426BFA304FD2" modified="2016-07-06" version="1" fragment="single">MEDDLEKVGYLKRLGHKTMGTVRENIIISILHALSKEALCVCDLAALLGMKQSAISHQLRILRGARVVKFRKEGRMAYYSLDDKHIEKLLEVATKHVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V937</accession>
    <name>A0A133V937_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pfdA</name>
        <name evidence="8" type="ORF">AKJ48_04360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000096">
        <property type="protein sequence ID" value="KXB02968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02968">
        <property type="protein sequence ID" value="KXB02968"/>
        <property type="gene ID" value="AKJ48_04360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PTHR12674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="153" mass="17142" checksum="1FF96F302AA5DE4F" modified="2016-07-06" version="1">MEEKTEGESQELQKILLDLRESQQRAQGLQTQIKLLSNSVEEIDNTIGTIQGIKNMNSETDILVPIGGNSFLKAKLIETDKVLSGFGAELVAERNPDQAIEFLEQQKKEFNESIERARGELEKLSQHIEDLRPKAEELMAKTEGEEGASKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V954</accession>
    <name>A0A133V954_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_04390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000098">
        <property type="protein sequence ID" value="KXB02949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02949">
        <property type="protein sequence ID" value="KXB02949"/>
        <property type="gene ID" value="AKJ48_04390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="225"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="430" mass="51188" checksum="404B631D3473E9C3" modified="2016-07-06" version="1">MVDREVWIEQIKDFYETELPEVVKRDIRVPKPPINRAISIIGPRRAGKTFFMFQLMKELLEENLEKERILYINLESDLLLGCELADLRNMMEIFYEIYPENKDRKTYLFLDEVQNVENWEKFVRTIMDSEDVQVYVSGSSSKLLSKEIATSMRGRTLPYHVYPFNFREFLRAKNFDVGEHLSSSEKAKLLNLLEEFMKGSYPEVILFEREREKILREIIDVTIYRDIVDRFNIRNIKVLKLLLKALISSTYFSVHKFYNYLKSLGMKVSKNTIYRYLDYFSDSLIVYPLRKYSKSYKEIEQTIPKIYLADNGLLVHNNIRSSGRLMENAVFTELMRRGYTPNKELFYFSSDRKEVDFVLVEKGAVTQLIQVCYRIDDLETRDRELSALVKAGKELGCSDMQMITWDYADIEKYEDQEIKFLPIWKWLLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9B1</accession>
    <name>A0A133V9B1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000094">
        <property type="protein sequence ID" value="KXB02995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02995">
        <property type="protein sequence ID" value="KXB02995"/>
        <property type="gene ID" value="AKJ48_04345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="69" mass="8229" checksum="5FA803145E708E02" modified="2016-07-06" version="1">MRARNSSKRILRDILDKFKRYVSVCILALLLRLMEKKAGSLLEKIFKEFDPLKANVIVQMREEIFSKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9B7</accession>
    <name>A0A133V9B7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GMP_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000093">
        <property type="protein sequence ID" value="KXB03005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03005">
        <property type="protein sequence ID" value="KXB03005"/>
        <property type="gene ID" value="AKJ48_04325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMP_synt_C" evidence="1">
        <location>
            <begin position="124"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="182" mass="20923" checksum="069D44231DA422E6" modified="2016-07-06" version="1">MEKFVERYFQENYGKTVLWDETTGFRTPFQYFAGTFDGVKKERKKVSEYLRGLGLKAKAFTLENKVTGVMEEDGGRKRSYSSPVLLEGGLEQEMVFFLGKKIPELFKTSRVLFKLSEAREHESSKWLVSIRAVSSKDASYADPLQIPLEELERWGDEIIAKTNTRVVAYDVTPKPPATIEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9U2</accession>
    <name>A0A133V9U2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CbiA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000081">
        <property type="protein sequence ID" value="KXB03201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03201">
        <property type="protein sequence ID" value="KXB03201"/>
        <property type="gene ID" value="AKJ48_04115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="250" mass="27948" checksum="2C0BCC6C67A51490" modified="2016-07-06" version="1">MGIAGKGGVGKTTLAALFLRTLLERNSSTILAVDSDPNLCLPGLLGVEDYETLSSMIEKRRGSRLQPREFQQEFNSLLIKNEQDGYDLLPMGRGEGQGCYCAVNNLLRSTFRHIILSGNYAYDYVVVDCEAGLEHVSRKTSSMVDDLIIMTDGSRMGLNTVQKIRDVGEKVKIGIDNFYTVANKIDDEEVLREVQATSQEFGMTYLGNLPYDREVEKLSFEGKSVFELSDHSQVYLKGKEIVDRVLSRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9V2</accession>
    <name>A0A133V9V2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_04090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000080">
        <property type="protein sequence ID" value="KXB03219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03219">
        <property type="protein sequence ID" value="KXB03219"/>
        <property type="gene ID" value="AKJ48_04090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Putative_PNPOx" evidence="2">
        <location>
            <begin position="248"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="404" mass="46483" checksum="B44E97D2DA72ADF3" modified="2016-07-06" version="1">MEKGSWIHEFFLERVPPFSLFSRFKALILQLVIMEIIGLLCVIVFSLPIRSAIMGSAAILAVVVWSAIAHRMSLPIKRAKLPENPNDRDTVSKYRRLIFSKRHYEAIAGTIFAILLIFYIFFLGEQNLTFWLGSKIPVLPLGLGFLLLWEVSYRVGLGLWISLLALLRSSWLRKTVRERGGYVPYGSLDYLEDMDLRNMAMAFPTFLLIPLTLSDIALLLILLGIVVSIVTLSAISIFRLRQIPLYPDKIKELLKNGKFAYFGTSDENGQTHITPLIFVFDGRSVFIVTSKISKKLKNLQENPHAAVLIDVRDLENPTDNRAALLRGKTTTYSVFHALAHPIQMLRLRRLFQQKYPKYVKKYDERMDELPEAWRTALFIHRTLVRVDVEDMVYWEKAKVLQIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9X4</accession>
    <name>A0A133V9X4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiC</name>
        <name evidence="11" type="ORF">AKJ48_04055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="LHYB01000078">
        <property type="protein sequence ID" value="KXB03250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03250">
        <property type="protein sequence ID" value="KXB03250"/>
        <property type="gene ID" value="AKJ48_04055"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.832"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB03250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="425" mass="46385" checksum="47FFD54CBBFF1129" modified="2016-07-06" version="1">MQLEEAKKGNATPEMEAVAQEEDIPINQLIERITSGRIVIPSNVERDEVKPTGIGEGLRVKINANVGTSPDYADVEEEVEKAKIAEKYGADTVMDLSIGGDIDEVRRRILEAVKAPIGTVPIYQAGIKAAEEGNVVDMSSDDIFNGIRKHAEDGVDFVTIHCGVTRKAVEALKERRRLLGVVSRGGSFLAAWILHHGEENPLYKEYDYLLEIAQEYDLTLSLGDGLRPGCLADASDHAQFQELLTIGELTERAQAKNVQVIVEGPGHLPLDHIEANVKLEKSICKGAPFYVLGPIVTDIAPGYDHLVGAIGGALAARAGTDFLCYVTPSEHLCLPNIDDVKEGVIASKIAAHAADVARGINTELDDKMAEARRDFNWGKQSELAVDKEKALRMREERPAQVDPETCSMCSDFCALKMVRDYLEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA26</accession>
    <name>A0A133VA26_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="11">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrS</name>
        <name evidence="13" type="ORF">AKJ48_04080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="11"/>
    <dbReference type="EMBL" id="LHYB01000079">
        <property type="protein sequence ID" value="KXB03237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03237">
        <property type="protein sequence ID" value="KXB03237"/>
        <property type="gene ID" value="AKJ48_04080"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.837"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="12">
        <location>
            <begin position="202"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB03237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="615" mass="70290" checksum="FBE69881D45E6A17" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA80</accession>
    <name>A0A133VA80_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000073">
        <property type="protein sequence ID" value="KXB03360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03360">
        <property type="protein sequence ID" value="KXB03360"/>
        <property type="gene ID" value="AKJ48_03965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="213" mass="22988" checksum="7CC58CA01383CB79" modified="2016-07-06" version="1">MNIYRVGGYGFGSNVYLILDEVITLIDAGTGSNFKQVQSELQGHDIELSDIDLLINTHCHYDHTGGDSKFIEASNCELAAHELAAKPLEDGDPTLTLAEFFGEELEPLKVSRILVDGDEIELGDSTLEVLHTPGHAQGGISLYDSQDRILFSGDTVFRGGIGRLDLPGSDSSAMIKSLQKLSQIDVDKLYPGHGPIAAEDGGKYVKTGLDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAD6</accession>
    <name>A0A133VAD6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_03890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000070">
        <property type="protein sequence ID" value="KXB03428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03428">
        <property type="protein sequence ID" value="KXB03428"/>
        <property type="gene ID" value="AKJ48_03890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="5">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB03428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="244" mass="26645" checksum="543CDAC3CE51E103" modified="2016-07-06" version="1">MLRPIIIGGYRKSGKTQLIKKLVKELSNRGYRVGTIKHVPQEGFTLDQPESDTWRHAQAGADPVISISPEEVATLEKRKASLEEVLLSLHDLDFVVIEGFRKSENIAKIITARSEGEAKELNDEFTIGFIGHGVENKPVLDQEDVDSLADLIEQKSIPPVGGLDCGECGYDNCREFALAAINGEASKDGCTPLQGPVILRVDGERIPIKSFVKDVIGKAVSGIVSSLKGAEGRKIEIEVEKDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAG2</accession>
    <name>A0A133VAG2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000072">
        <property type="protein sequence ID" value="KXB03385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03385">
        <property type="protein sequence ID" value="KXB03385"/>
        <property type="gene ID" value="AKJ48_03950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007166">
        <property type="entry name" value="Class3_signal_pept_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04021">
        <property type="entry name" value="Class_IIIsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="90" mass="9445" checksum="7D89EBC02105EEA2" modified="2016-07-06" version="1" fragment="single">MKILDRRGQGATEYLLMLAAVLVIVAAAIYYVTTAGPSAVVTGSATLDENNDVIFTPSSSMTPTKISAGEWDWAVYRGASKIGSNTADTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAJ3</accession>
    <name>A0A133VAJ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000068">
        <property type="protein sequence ID" value="KXB03471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03471">
        <property type="protein sequence ID" value="KXB03471"/>
        <property type="gene ID" value="AKJ48_03865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="407" mass="43934" checksum="CDB9CF97331D8013" modified="2016-07-06" version="1">MSEDSNPFISLLRENRDFATLWFGQIVSRIGDGILIVALPWLIYKIGTETDLGLIMALYSLAAVLFGYIAGMTADRFSRKRLMIMSSIGAGVFVTLMPVLYDSGLLVIPLLGILAFLASLCSQFFEPALDASIPNLVEDDMLETANSMSMTTRRVGMIAGPAVAGVLITVTSSSTTLLIDSISFFFLAGIIAFISVPQKIPDRRNSIWSDFVDDTGDLFSYVKSQPLIRLILLLTLVVNAVLGPFFIITVVFTKNVLASGSGSFGLLVSILSLGTVAGMLTVGQFKEIHAKKFILLGFSLSGLSLIILSQTRWLGLAVGLYLLVGIGFGVINVPAKTALQRFSPDKLRGKIMGITFTMASAAQPISQASSGFVLSFIDTPIMFLFMGMGVLLLLLPLILSEELERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAV6</accession>
    <name>A0A133VAV6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000064">
        <property type="protein sequence ID" value="KXB03582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03582">
        <property type="protein sequence ID" value="KXB03582"/>
        <property type="gene ID" value="AKJ48_03735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="137" mass="15985" checksum="BCFF0411C1727009" modified="2016-07-06" version="1" fragment="single">MAPLKRLDLPVKAEVYGVDHPELPDNSYILRMDPAKKILYNPLLWGSKLRDYTRKCNQIFLKAEQEISPDFSDLRTEEVCEIVVLRGGLGYRLDDAFEDVFDSYLPQCFVGARRHRVSEEEFRAEINYTNFDPLPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAY4</accession>
    <name>A0A133VAY4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase_M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000063">
        <property type="protein sequence ID" value="KXB03616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03616">
        <property type="protein sequence ID" value="KXB03616"/>
        <property type="gene ID" value="AKJ48_03730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.737"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB03616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="159" mass="16848" checksum="62E264B367DB25CA" modified="2016-07-06" version="1" fragment="single">VGLYLSPTPLPEEGAVLHLGRPLVYRALTLLVPAGGGELHPVAFAGWVGFFVTFLNLLPVGQLDGGHVFRALLGERHRAVSGVVPFLLLSMGFILTSLGAAGGVWIFWGFITMFFHLGGHSPPLDDVTELGARRKAVGVLVLVLMIACFTPVPFAVAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBA5</accession>
    <name>A0A133VBA5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000060">
        <property type="protein sequence ID" value="KXB03729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03729">
        <property type="protein sequence ID" value="KXB03729"/>
        <property type="gene ID" value="AKJ48_03660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="223" mass="24935" checksum="BB9DACA9DEF0A91D" modified="2016-07-06" version="1" fragment="single">MHGKNPLASVFIPVRNEEEHIEECLNSLVNQDYPNDKYEIVIVDGKSEDQTREIVKKFMKQHDNIRLIENPELNVSAGRRIGVEESRGKYVIAFSGHSYADRDFIRKVVTRLEKADEEIAGVGCRHETPPGDSSTARAIGLAMSSTFGGAGTTFKQPEKEQVVDSVAFTAYRKKVVDEVGGPSDPDLERTGNDAELNLRIKEAGYKLLYIPDTTAYHHKKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBI7</accession>
    <name>A0A133VBI7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000059">
        <property type="protein sequence ID" value="KXB03775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03775">
        <property type="protein sequence ID" value="KXB03775"/>
        <property type="gene ID" value="AKJ48_03650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.700"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="291" mass="31667" checksum="A151EEB77F853A46" modified="2016-07-06" version="1">MKYDTIIIGHITIDVNVFPWGLIENVLGGAPTYTGFALTTLKKKAGVVSKLGQDFPEKFSPVFSKFGLDTEGILATSGQTTTFENTYDEKGGREQVCKVVSDSISPEDVPKSYQDTHSYYISPVAGEISPDVIESVKNSDNIVMFDPQGIFRDIGEGGKVNVKMPDNLEDYLKNVDIIKLGKGELKAFKENEEEVLKTLTEMGPKTAILTLGEEGCMILAGDKLEKIKGLDVEVKDLTGAGDVFGAAFLSNYLDTEDPFKSARIGVIAAGLKLQYKGPTGFPTMEEVEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC04</accession>
    <name>A0A133VC04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000054">
        <property type="protein sequence ID" value="KXB03979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03979">
        <property type="protein sequence ID" value="KXB03979"/>
        <property type="gene ID" value="AKJ48_03530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="68" mass="7578" checksum="997AE5B2CDE20C3B" modified="2016-07-06" version="1" fragment="single">MISEEFQDKGKACLPLNHNTVSSTLTSLLTRLGRERLEVEQVGTIEKIEGEPRPEISDDLKDKALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC29</accession>
    <name>A0A133VC29_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000053">
        <property type="protein sequence ID" value="KXB04006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04006">
        <property type="protein sequence ID" value="KXB04006"/>
        <property type="gene ID" value="AKJ48_03480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.658"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="333" mass="38436" checksum="A17D04D5240BADE2" modified="2016-07-06" version="1">MREKLSKLGLDLPTLPTTAVGSYPKPAELKKARRKFLKGELKVEDLRPLEEKATREWIKIQEDVGLDVLVDGEMYRGDMVTYFARNLEGFSISGLVRSYDNRYYRKPVIKDKIEWTKPITVDYWRYAQELTEKPVKGVLTGPYTMMDWSFNEYYPNRKEACLALARALRKEVEALADAGAKIIQIDEPASSARPEELPEFGEEAMKIMTNGIDAYFITHICYGAFEFIYPEMLNLSVDNFDLEMSNSDLDLVELFEKKPFTKDISFGVIDVHSHVIEDEDTVKSRIERALETLDTNQVWIDPDCGFKTRTKEETIEKLKVLVNSVKETRKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC80</accession>
    <name>A0A133VC80_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000052">
        <property type="protein sequence ID" value="KXB04035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04035">
        <property type="protein sequence ID" value="KXB04035"/>
        <property type="gene ID" value="AKJ48_03450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="84" mass="9442" checksum="CE9DD12C001117A4" modified="2016-07-06" version="1">MTFMDEAIFLLEPILKHGWFLKGSKPSCSVNWSRGKECVFGAMTPGNGGKLLSKQAKKINSENFIEYVQYLLDENGSQVLYGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC96</accession>
    <name>A0A133VC96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000052">
        <property type="protein sequence ID" value="KXB04037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04037">
        <property type="protein sequence ID" value="KXB04037"/>
        <property type="gene ID" value="AKJ48_03460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="68" mass="7978" checksum="5450C482D56009CF" modified="2016-07-06" version="1">MKEPKTSFGIRIDEDLVKDLDKIVKESDDLNVSRSEVVESILMAYFKSDTDHVKKARELIIRKRKEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCK7</accession>
    <name>A0A133VCK7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000047">
        <property type="protein sequence ID" value="KXB04178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04178">
        <property type="protein sequence ID" value="KXB04178"/>
        <property type="gene ID" value="AKJ48_03290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="228" mass="26061" checksum="EF89B84CDF36BE93" modified="2016-07-06" version="1">MRIRQDQQGFVLSGTALLLILPAMLLTASFFEAVTVGGESAYLQATSDKVFYTGKDIERVIKDMWTENIIISDNTPVPNPMFDHLADNYEAATGLIVDITPRWMLWSVKDDSENRFLSENDKIERVGANKWRYRWDTVLIRNDNDDPILLVEKLNDNLRITLEDFDTVFPLWKADIYYDDIKLWDDVVPDDPRIGENVVVDGTTQLIVSINVRDPRGAARYSSTVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCU7</accession>
    <name>A0A133VCU7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000045">
        <property type="protein sequence ID" value="KXB04269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04269">
        <property type="protein sequence ID" value="KXB04269"/>
        <property type="gene ID" value="AKJ48_03220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="54"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="192" mass="20873" checksum="0FC88E576357E30D" modified="2016-07-06" version="1">MNTSGLASSIIAIVVVGLIIGVMGGIYFMVTSSPRNSASGGENIGGEENVSIGTEVGERAPDFTLTDIDGNTFSLSDYRDNVVIVDFMATWCTWCVYEMPDLVNFHEDYSSEGVVMLSVDVTTSETREQLRSFKNEYGAGWTFARDTANVGTTYKVVGIPTKYMINQNGVIVWKHSGATSYSTLESEVSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCX8</accession>
    <name>A0A133VCX8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000045">
        <property type="protein sequence ID" value="KXB04267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04267">
        <property type="protein sequence ID" value="KXB04267"/>
        <property type="gene ID" value="AKJ48_03225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="231" mass="25068" checksum="1C92E5A7DAF4FE4E" modified="2016-07-06" version="1">MINVIDLALIGLAFSAGIVAFFNPCSYALLPAYISYYLGKHDDEKKTESILKRGLEGVGVGIEVTLGFLSVFVIIGVLISLVSSQIGAYLSWLIPGVSIILIILGLLWLLDIPLSFPHSFEAPKRGKHVSFYLFGVLYALGSAACVLPIFLMVTLSALTASGFLSGLLVFLSYALGMGIMMIGVAIAVALSKNVLLEHFKKIMRYVRKTGAIILIAAGIYLIYFWYTTYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCY9</accession>
    <name>A0A133VCY9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000040">
        <property type="protein sequence ID" value="KXB04316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04316">
        <property type="protein sequence ID" value="KXB04316"/>
        <property type="gene ID" value="AKJ48_03010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="71"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="403" mass="46262" checksum="C6A581ADE09FE103" modified="2016-07-06" version="1">MPTFNMKPREVIGMESIEKIMKKSNIRQTLEPLYQDDKLIDEGNWDKYLREFEGIKSNVPTREFWKDKKVLVTGVGGFVGSNIAEKLIKLGSRVIGIIRTPELHKYPNLHDLEDSIELHVCDLTDYGHVDEIVKEEKPEILFHYAAISFVPTSLKEPNRVFQNNVSSAINLLKAISKHGQSSIQAIYTALSSEQYGYMTHLDEFPVKENQIFRPTSPYSVSKIATEYIGESFFYNSKLPVLRIRTFNQESVGNPEKMRRARDDRFFTMVVAKQIAEYQSGERDKIIIQNPNSLRDFTHIRDSVAAHLLGVEKCKPNEPYNVCSGYGILTGDFTKIACHLYDISEDKIYCDTSKLRPYEMYGDALVHGFVGDNTKFCQETGWRPTLSLEDIIKESVEYQESRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCZ4</accession>
    <name>A0A133VCZ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000043">
        <property type="protein sequence ID" value="KXB04287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04287">
        <property type="protein sequence ID" value="KXB04287"/>
        <property type="gene ID" value="AKJ48_03130"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.561"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="3">
        <location>
            <begin position="264"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="405" mass="44821" checksum="2CE30C1265C6E7A1" modified="2016-07-06" version="1">MARVLAGYDAVAEAVKSCDPDVISAYPITPQTDIVERLSQMKADEELSGEFIKVDSEFNAASTCIGASAAGARVFSATCSQGLKLMSEVLFSASGMRLPLVLAIANRSLSAPLSIWGDQTDTFAERDGGMIQFYAEDVQEAMDNILMAYRVAEDREISLPALSCLDGFILTHVQEPVELFDEEKVKEFLPDKAPEFTLDPSNPVTMGAYARPEHWTETRYMVHEAQMKAKNKISDATSDFAEIFGREYGLEHDGLVSTYKAEDADIVLMALGSVCGTIRYLVDEYRDNGEKIGLVRPRVYRPFPIKQLRKILEGVEAVAVLDKDISPGYQGGLAIDLKSALYSTNIRGPVLNFIVGLAGRDVSKDNIRNIIEKTKSVAEKGTHEMEFEEEEDWEPLYTELLPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD35</accession>
    <name>A0A133VD35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04327">
        <property type="protein sequence ID" value="KXB04327"/>
        <property type="gene ID" value="AKJ48_02955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="99" mass="11292" checksum="67EF95DEF64EA3D9" modified="2016-07-06" version="1">MSRKKEGFVNEAGVHSNGVENQWSMDRDWVERARGYNSIESLVRAVKGRQAYHNQVKNSPVPVWAFLKIAISDSNRGYFLFIFHPTSSLEAPQGLQQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD37</accession>
    <name>A0A133VD37_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">AKJ48_02865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04368">
        <property type="protein sequence ID" value="KXB04368"/>
        <property type="gene ID" value="AKJ48_02865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.475"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="216"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="31"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="340" mass="35708" checksum="0E58614D9297D16B" modified="2016-07-06" version="1">MSGSYSENSEGRLKQASRNGRPTILVVGCGGAGCNTITRVSGGELRGAETIAVNTDAQDLLNAEADEKVLIGREVTNGLGAGGEPKKGRESALKEKGILKEALSEHELVFLTYGLGGGTGTGAGPVIGEIAKESGALTVAVVTLPFEAEGEERNRKAVEGLSRMEEAVDTTIVIPDDRLLEITPDLSLPQAFERADKVLKDAIAGVVELATEPGLINLDFEDILATFEGGGTGVIGFGKSTGERRVEEAVEEALGNPLLDMDVDRAERALIAVRGSPDVSLREAEELVEKVSEKLDPDARIAWGARTSEDLEDSLKVMIMVGGAGSDEGTEEMDFGLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD44</accession>
    <name>A0A133VD44_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000038">
        <property type="protein sequence ID" value="KXB04341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04341">
        <property type="protein sequence ID" value="KXB04341"/>
        <property type="gene ID" value="AKJ48_02935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="331" mass="37474" checksum="A4489AF97B1BEC1F" modified="2016-07-06" version="1">MYQDFLVEALTLLTTCEETLEGVAKYLNISKHMVELSEQTMIDYLDGNVTKSIEVDGDMVVIYADFSGTQISKKSGMIMSKVGEEVAYKVCPVMNYLTAWNFVKGLKERLETDDDATVVFVTDGGKAWLDPIQSFFPEAVHIRQFHSKNCRSLVFVHLRHDEEPYTVRFPWNTVLEMGEASKDTRRMRQRRKLKGSSSRSVESRIELSDDIIVRKGIAKHPRGRRNKDEGATVPEAMDGGEKPGRLEDLQEKKDSEDSKGDSEGSEETSEEDADRREKRNIASGTDGPSRIFKGELKEAMEIPPVRRAFSILKRVFGGHYITSNTAETLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD53</accession>
    <name>A0A133VD53_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04386">
        <property type="protein sequence ID" value="KXB04386"/>
        <property type="gene ID" value="AKJ48_02820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="83" mass="9472" checksum="5802E5F69B648859" modified="2016-07-06" version="1" fragment="single">EVVEALRPIIPLKFETRRIAIKIPPKYAGKAYRIVDESAEIKKDEWLDDGSWAVVVEIPAGTQPEFFEKLNNFTQGEVETKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD74</accession>
    <name>A0A133VD74_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000034">
        <property type="protein sequence ID" value="KXB04390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04390">
        <property type="protein sequence ID" value="KXB04390"/>
        <property type="gene ID" value="AKJ48_02715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="80" mass="8911" checksum="190AC388D0E7CBBC" modified="2016-07-06" version="1">MEPQLGQNLTLSERKARINRVKGRQMKEGLTPNALASIWRHLSGRVLPSLLPFRIGDSTFTLLLIFHLTSSVSLNKEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD83</accession>
    <name>A0A133VD83_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp41</name>
        <name evidence="9" type="ORF">AKJ48_02810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04385">
        <property type="protein sequence ID" value="KXB04385"/>
        <property type="gene ID" value="AKJ48_02810"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.465"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="7">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="8">
        <location>
            <begin position="153"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="240" mass="26609" checksum="2A33BA474246194F" modified="2016-07-06" version="1">MEEPEQLITDGKRIDDRKPEEMRPLKIEAGVLKKADGSAYLELGKNKVLAAVYGPRELHPRHLQRPDRAVLTCRYDMAPFSVEERARPGPSRRSREISKVSREALEPALFLQKYPRAGIEVSMEILQAGAGTRTAGISAASVALADAGIPMRDLVASLAAGKADDTIVLDLGKEEDQLGEADMPIAYMPQKEQITLLQMDGNFSPDEFDEALELAIEGCKQVYEKQREALSKKYAKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD86</accession>
    <name>A0A133VD86_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">OMP decarboxylase</fullName>
            <shortName evidence="3">OMPDCase</shortName>
            <shortName evidence="3">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pyrF</name>
        <name evidence="5" type="ORF">AKJ48_02630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000032">
        <property type="protein sequence ID" value="KXB04416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04416">
        <property type="protein sequence ID" value="KXB04416"/>
        <property type="gene ID" value="AKJ48_02630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.424"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_A">
        <property type="entry name" value="OMPdecase_type1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="247" mass="26403" checksum="FBDB7241098F21CA" modified="2016-07-06" version="1">MVGEKFRKALAEKSQENNSKLILALDVSGKGIAKKQIEQKSLDILEDSLNFLVAVKVGYPLVLSTGLEIIHKIRKLGELPIIADFKIADVPHINRQIARYAYESGADAVIAHGFTGRDSLEATISIAEEMGGKGVIVIPDMSHLGGEMFIKPSSKQIVKLAKETGATGIIGPATRPEEVTALRSLAGDKMLILTPGIGTQGARPGDAIKGGADYEIVGRSIYTSDSPGKAARLIRDEINEVIKEESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDA7</accession>
    <name>A0A133VDA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_02760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04384">
        <property type="protein sequence ID" value="KXB04384"/>
        <property type="gene ID" value="AKJ48_02760"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.455"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="3"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="104"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="300" mass="32625" checksum="FB35D4276DC3A58C" modified="2016-07-06" version="1">MKVLVTDPIHEDGIKKLEEFADVEVATGLDQESLLEKVPDFGAMIVRSATKVGKDLLDAGGNLKLIVRAGVGLDNIDLDTAKERNIKVVNTPEAPTTAVAELTISLMLAWARKIPKADKAMKEGKWIKSQLVGTELKDKTLGIIGTGRIGREVARRAKALGMNLLGYDVEKSDEFKEMGGEYVGLEELLQNSDYVTLHVPLIPPTRHMISEEELNLMKSTAVLVNAARGPIVDEEALIKALKNEKIAGACIDVCEHDPPEESPLTQLDNVILTPHLGASTREAQRTAGVLAAEKIRENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDB4</accession>
    <name>A0A133VDB4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000033">
        <property type="protein sequence ID" value="KXB04407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04407">
        <property type="protein sequence ID" value="KXB04407"/>
        <property type="gene ID" value="AKJ48_02700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.439"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="353" mass="39665" checksum="5DAD08898BAEEA1B" modified="2016-07-06" version="1">MKLFTVGPVACRPEILEEMRRQMFSHRSKEYKELHMELVKRLQDFLETENQVFLFPSSGSGVMETSVRNCVKEKMLCCVNGTFGERYAQVGESNGREVVRLETKLGEPTTPELLDEKLSENPDVEAVTITHNETSVGLMNPLPELAKVVSDHEKLLFVDAVSAMGGTPIKVDEWGIDICFASSQKCFGVPPGLAVASVSEEAMSQSGKLENKGWYFDLKLYEEYEEKKSGTHMTPPIPQILALNKRLELMDEDGKENHFELYLERNQKIREGVEDLGLSLFPKEGYESPTVTCVNAPEGVSGPEVYEKMRGKGFELAKGYGEIKERTFRIGNMGHILLEDIDEMLKALGEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDD7</accession>
    <name>A0A133VDD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04466">
        <property type="protein sequence ID" value="KXB04466"/>
        <property type="gene ID" value="AKJ48_02505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="196" mass="21569" checksum="E9FC3BB23811AC25" modified="2016-07-06" version="1">MENLIKIWVDNKPTLSFALLPLTDTTGHIYGHESDNYRQAIERADNAIGLLISKLKEEDAYQESLIVITADHGMTSTTHGSKSAGDMTIPLILSGPGIQPGELKDAEIIDVTPTISALFGLRAPKDTEGRNLFAQPAGVSMIYIAIGAGIILAVMLIIFIVRRRSREKTSEKMEDMSRNVNGRESSRNYLWTVHGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDE5</accession>
    <name>A0A133VDE5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH dtxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_02520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04469">
        <property type="protein sequence ID" value="KXB04469"/>
        <property type="gene ID" value="AKJ48_02520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="145" mass="16576" checksum="A98755E93C5B993E" modified="2016-07-06" version="1">MEIELNPEESSESVEEYLEALWVSEEEEKPLAKIKWISEHLDVAPPSAVEILKKMEKQGYTDYEARKGVKLTKKGRKIARQTIRNHRLIETLMKKTLGQEVDEKVACGIEHHLTKEFADALCTELGHPRKCPHDDPIPKGDCCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDF8</accession>
    <name>A0A133VDF8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000031">
        <property type="protein sequence ID" value="KXB04434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04434">
        <property type="protein sequence ID" value="KXB04434"/>
        <property type="gene ID" value="AKJ48_02620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008900">
        <property type="entry name" value="Zot_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05707">
        <property type="entry name" value="Zot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="2">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="449" mass="51261" checksum="49864C9AE2EE6EB1" modified="2016-07-06" version="1">MIVEDNLSVAQVARIFKCSPSAVCASLDIALGRGGHPKSGLRRFLDDLGVYGKNSIKKFIPSLVFTIRRKKLALFLNRLYACDGWMTTDEGRVEIGYATSSKRMARQVQHILLRFGILSVLREKRTSTETAYSIIIQNTHFVKKFIDEIGGFRGDEKTEKIRLLCECESNPNIDTIPKQVWSIVEEIRQKRGISWADVGFMSSKKNYAPSRKTLKKIARALHSPHLLNLAESDVFWDEVASIKDVGEKRVYDLSMNPTSNFLANDIFVHNTALGMKFLSWYGHNTDRKCYGIGYTDADLPQWIGKAGSLEDIPNDSVVLIDEAAILFFSREAMKSMNKTLSKLMSVARHKNLTLILITQSSAMVDLNVLRLADVLLFKEPSLLQARFERKSLKDLFEKVDTVFEEIEEEKVAHFYVFSDEYEGLVQYDLPYFWNDSISRAFKEFKAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDH7</accession>
    <name>A0A133VDH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04467">
        <property type="protein sequence ID" value="KXB04467"/>
        <property type="gene ID" value="AKJ48_02510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="178" mass="19706" checksum="9F0F32B61A2F4CA0" modified="2016-07-06" version="1">MVICMNRKILMSILVLILATGFTVTILPTAATREDSPQYVFLVTIDGCRPDVLQSASTPNIDNLLENSAYSWQAQTVYPSVTPVGHASLFTGATPETHGWSRYNYGYDVPLEAETVFQVFEEAGYETAIVDGKGGERIGGTEVDVTYVKNNVDYRWEIRIYLTTHMIQGQKISSLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDI8</accession>
    <name>A0A133VDI8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04516">
        <property type="protein sequence ID" value="KXB04516"/>
        <property type="gene ID" value="AKJ48_02340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="312" mass="35116" checksum="5913CF985430EC0E" modified="2016-07-06" version="1">MTLAYSPGGELGGENKEIIVGEWEEFRVSLTNDSPPTASPWENILIRVKFYGVENEEISLGYKHDGVWENSQVYDLRSLEQGMIGVVADLGPARGWTVKPQTTENFDLRVKIDKVVKDVKVEMLAITNESTLGAGGEKVENLESKNILDPLQDTYIHQGNPSTNYSGEDYLELTTQENGNAHALLEFDRQDIPNQVGSAELNLYQYWGSGFSDLRDSGITVQAFPIAENLNLNSVTWKTTPVHNATNPIAEEEIQGTNKSYNFNMTNYLNSLENEKIVTVLLKFSQDNFDNKERRIRFDSLEGENPPYLIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDL0</accession>
    <name>A0A133VDL0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hel308</name>
        <name evidence="4" type="ORF">AKJ48_02285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000025">
        <property type="protein sequence ID" value="KXB04529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04529">
        <property type="protein sequence ID" value="KXB04529"/>
        <property type="gene ID" value="AKJ48_02285"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.320"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="235"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="726" mass="81543" checksum="F073CF7D0DA56505" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDL1</accession>
    <name>A0A133VDL1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_02305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000025">
        <property type="protein sequence ID" value="KXB04532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04532">
        <property type="protein sequence ID" value="KXB04532"/>
        <property type="gene ID" value="AKJ48_02305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.324"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="381" mass="41817" checksum="CED305DF77B0E89E" modified="2016-07-06" version="1" fragment="single">DNGNTTPVAGEVVEAMLPYFTEKYGHPLFIYSLGREANETVESASETIANTVGARGSELTFTSGATEANDLAVRGIAKANKDKGKHIVTSRVENPSVLRITEELERRGFEVDYLDVDSEGFIDLEQLEDLITNETILVSIIHASDEIGTIEPLKKVGKILKDQNHEILFHTDAAASYARIPIDMDEMNLDLVSISAHKIHGPKGIGALIAREGVNIEPINYGYLSLSNLRPGTENMPGIVGFQKAVELAFENFDSKIDHMKKLRDKLMEGVEEKIPETVLHGPRGGDRSPANVNYSFKRVEGESILMQLDMRGISVATGSACATRKLEPSHVLTAIGVKPAVAHGAIRFTLSRMNTEKEIDYTLEVLPEVVEKLRELSPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDL2</accession>
    <name>A0A133VDL2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenylosuccinate lyase</fullName>
            <shortName evidence="9">ASL</shortName>
            <ecNumber evidence="5 9">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ48_02290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="5 9"/>
    <dbReference type="EMBL" id="LHYB01000025">
        <property type="protein sequence ID" value="KXB04530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04530">
        <property type="protein sequence ID" value="KXB04530"/>
        <property type="gene ID" value="AKJ48_02290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.321"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="360"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB04530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="449" mass="50571" checksum="EFABF82989590A97" modified="2016-07-06" version="1">MPVHPIENRYGSDEMRAVFEEETRFQRMLDVEGALAKALAAEEMIPKTHGQKIARKAKIKHVPVKKIRKLEEKTGHETMALVLALAEVSGTGSRSVHFGATSNDILDTAMALQFRDALEVLEKRMRDLLEVMIKQAKENVDTVIVGRTHGQHAVPTTLGMKFAIWASEMGRNLKRLEEVKSRVLVGQMTGAVGTGAAWGEKASKIQKRVMEELELESVEISNQVIQRDRFAELISFLGLLGGTLAKVGREIRNLQRTEISEVSEPFGEEQVGSSTMPHKRNPIKSERVCGLARVLRANVQAGLENMVIEHERDLTNSSCERVLLPESFLIIDQMFLDQEEVLENLRIRAKRMEQNLKLTQGLNMAEAVMIEVTRRGMDRQKAHKALRECTSYALREGVSLSSALQQNGEILEHISKEEIRDLLNPKKYLGNAENTVKKVIKNLEKIQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDM9</accession>
    <name>A0A133VDM9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04556">
        <property type="protein sequence ID" value="KXB04556"/>
        <property type="gene ID" value="AKJ48_02190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="282" mass="29953" checksum="AFAA136033C84CFB" modified="2016-07-06" version="1">MNGGFAAAVLPVTVSLIGDVFEEPKAKMNSIGAVLGMYFLGAAAATAIGGGLSFIGSWRYVYLTYGIAEFILVVLIYKFLTFREGTVDKLSFREAYGDAISHSDLLRTVSLLFLVGFTVFGSFTYLGDYLVQQTGYNLLSVGLILTLFGLAAFAGGRNTGSLKEKVGSKILVIAGVLGLVSLLIVSYWLGIYFVLPALVGFGLAFVILQATIITTAQQYLPTKSGTVMSLASFNMFVGGAVGVFTNRIILNQLGYQGLFMVAGLAILTVGILAFLIISPYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDP1</accession>
    <name>A0A133VDP1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04560">
        <property type="protein sequence ID" value="KXB04560"/>
        <property type="gene ID" value="AKJ48_02210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="83" mass="9310" checksum="70EE8D969BAF4DAA" modified="2016-07-06" version="1">MPSSIFPAPGTYGYSPFLLKRLDEMKNRGYELSNPGLYYHLSELKDAGVIEVSSYVEEGRGAPEKKWKLAREKIEIDLVGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDP9</accession>
    <name>A0A133VDP9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-ATPase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_02080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04569">
        <property type="protein sequence ID" value="KXB04569"/>
        <property type="gene ID" value="AKJ48_02080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="116" mass="13301" checksum="553271F02F42D985" modified="2016-07-06" version="1" fragment="single">MEGSDKIIQQISDKAKEERESILEEARKKAENLKSAAQKKTDAEAKKVIREGEMEAEREKRRILASARTKARQTKLEAKERLIQEVFETAKSELAKLRDDNQEYQEILENLIVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDQ8</accession>
    <name>A0A133VDQ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_02160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04561">
        <property type="protein sequence ID" value="KXB04561"/>
        <property type="gene ID" value="AKJ48_02160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.291"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="390" mass="41879" checksum="9D816ED58ECD1836" modified="2016-07-06" version="1">MDENTGSGLVSSEGDGWVYLDHAATTPLAEEAVSAMRPFLEGRHENPSASYGGSAKRAVEDARGKVASLFDTDRENVIFTGCGSESDNMAVKGVFETEDGDHIVTSTIEHPAVRNACSFLERKGADVTWVSPDEDGRINPSDVENAVREDTILISIMHANNETGVIQPLREIGEIADENDVLFHSDTVQSAGKIPTPADEIGLDLASLSAHKFYGPKGVGALYVRDGTELEPLIHGGGQERGLRGGTENVSGIVGMGKAAELALADLEERKNRLSGLRERLIEEVRGRTGARLVGDPENRLPGYALFCFEDMSGPEIVEALAERGIAASSGSACHSGDPEPSRVLKEMGVERKYATGTLRISMGRKTTEEDVDKVVKNLEEITEEVRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDT0</accession>
    <name>A0A133VDT0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000021">
        <property type="protein sequence ID" value="KXB04599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04599">
        <property type="protein sequence ID" value="KXB04599"/>
        <property type="gene ID" value="AKJ48_02060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="13"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="389" mass="41849" checksum="001BA9CAF6E644E8" modified="2016-07-06" version="1">MSDDHGPIYGQSKLQIIFAITLLGVMAVSLLSPAFPSIRDHFGVTENEVGLLITAFTLPGIFLSFFIGSLADWFGRKQVLVPALFLFGVAGGACAIAPDFSTLIILRFFQGIGGAALVTLAVTLIGDYYDGIERASAIGANASVLSIGTASYPFLGGVLTEFSWVIPFLLYLLAIPVGIIALFFLRNPEQGDFSIHSYLHQISRLIIKPRTLGAMVASALAFIMLYGGIITYFPQLMNERFTHSPLTIGAIMGSMSIAVAIISSQTGKLVKRFPMDLLIITGFFLYGVGLFLIPLIPQIWIFLVPMIIFGFGHGLILPNLQTLFSRLAAREHRGAMMSLFNISTRTGMTIGPLILALSFAVGGFSMVFRSAALLSLIASGIGILVVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDT9</accession>
    <name>A0A133VDT9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuC</name>
        <name evidence="8" type="ORF">AKJ48_02005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04612">
        <property type="protein sequence ID" value="KXB04612"/>
        <property type="gene ID" value="AKJ48_02005"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.228"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="417" mass="44862" checksum="6668BB84E6D5A52E" modified="2016-07-06" version="1">MGMTISEKILSKASETESYAGEFVTADIDFTMAQDGTAPLAIKAIRNMSEGKVWNPEKIALVIDHTVPSSSIGTSTLHQMMREFAEEQEIKNFYYGEGICHQIMVEYGHVLPNTVIVGADSHTCTYGALGAFGTGIGSTETAGVFLSGKLWFKIPQTIKFEITGKLPKRTTAKDLALKIVGEIGSDGATYKAVEYSGTPIKKMSVGERMTLSNLAVEMGAKTGIIEPDKKVKKYLKNRTNKKLELVANDDDAEFENVLDFDIGDLEPQIACPHQVDNVVPVSEVEGVKVDQVFLGTCTNGRFEDLEAAARILKGKKVNSSTRMLVTPASREVYMKAIDKGLIKIFLESGCTVSSPGCSACAGSNIGILAPGETCLSTANRNFKGRMGSEEAEIYLGSAVTIAASAIKGEITDPREVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDV3</accession>
    <name>A0A133VDV3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate carboxyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04611">
        <property type="protein sequence ID" value="KXB04611"/>
        <property type="gene ID" value="AKJ48_02000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="435" mass="49151" checksum="D447FA8D24C4C4FE" modified="2016-07-06" version="1">MSSKFDEMEDARKEFLKELNKLSTLEFDLEKWEKLKELVYDPQPLDVDVVIDDTTLREGLQMPGILSPPPAEACRIASLLRDIGVERIEVLTYTKSDKEGIKRMRDEGLEDIIAGWCRASQKDIDSALKLGFKQIGVSHPVSFIHFEKWPDKSVKQLTDRVVDAVEYAVDHGLRVFVHGEDSMRAEWKFEKEFINAIAEAGAEVYRICDTVGCGVPNPDAPLPYGIQTKVKHIKEETDIPSIEFHGHDDLGNAVNNTTTAIEAASGLFDKVYASTTFAGIGDRCGNAETEKIMMNCYMHNNVKKWDLGGFKELADFLASALNYHLPVDKAIIGEGAFAHESGIHVHGVYTLPLTYEVFPPELVGQKRGIRIGKRSGRYTVKAKLEEILRSEVDKEDPRFKKLTKRIKNEFVKGERRAPLKDKEFKEWAREAGFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDW3</accession>
    <name>A0A133VDW3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-Thr_ED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04615">
        <property type="protein sequence ID" value="KXB04615"/>
        <property type="gene ID" value="AKJ48_02025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-Thr_ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="80" mass="8954" checksum="067691BD117552A1" modified="2016-07-06" version="1" fragment="single">EEIQDVAAMVKSKNIAIFPFAHLSGKLASPDFAISILGELESRVRKADYEVIRAPFGWYKEFEFRSKGHPLSALSRSVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDY7</accession>
    <name>A0A133VDY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04662">
        <property type="protein sequence ID" value="KXB04662"/>
        <property type="gene ID" value="AKJ48_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="313" mass="33556" checksum="93ED0AEA8A70382A" modified="2016-07-06" version="1">MVDPLNFIFSCLVFPGLIFACGVGCLFEGVDRKCAAHMQHRIGPPVWQPYLDIGKLLGKEDITPARSQRWMFTLAPLLAFGAILAVMTVLPVNSATPAFGSTADLIVVIYLLNIPAIALMLGGYSSSGSFGIVGSGRYVIQLFGYEFPFIIAALTVSAAVGSLSLATIVNFQSQNGWLFSQMPLAFIAALLVAPGKLLKTPFDIPDAETEIVHGPLTEYSGPKLAIFQLAYNMEMLAVAGFIAVLFLGGPTAFTVGGLQVPGVVSFFIKALAIVLLMTLIRCITARLRIDQALRFYWIPIAIIALINLAVVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDY8</accession>
    <name>A0A133VDY8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04614">
        <property type="protein sequence ID" value="KXB04614"/>
        <property type="gene ID" value="AKJ48_02015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.230"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="6">
        <location>
            <begin position="30"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="417" mass="46246" checksum="A63B5D62DFC6543C" modified="2016-07-06" version="1">MTEFEKIKVPEDGEKIVWDGKELQVPDNPIIPQIEGDGTGKDVSPAAKKVLKAAARETGRDIHWMDIHAGKTAKEIYGKYLPQETLDAIEEFRLALKGPLTTPVGGGFRSLNVAIRQKLDLYACVRPVYHLAGVPSPVKNPEQMDMVIFRENTEDVYAGIEWARDTKEAEKARDFLSEKMDTDIPSDSGIGIKPISEGASKRLIRKAIDYTLKNRDHYESMTLVHKGNIMKFTEGAFRDWGYEVAEDEYSGKVITEDELWEEHDGKVPEDVIVIKDRLADNMLQQLLTRTPLYDVLAMPNLNGDYLSDAAAGQVGGLGIAPGSNIGDGKGVFEPTHGTAPVHAGKDKVNPTGIILSGRIMFEFMGWEDAGELVKKSIEQTIKDKTVTYDIHRQIEGGKKVKCSEFADLVIENMKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE08</accession>
    <name>A0A133VE08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04665">
        <property type="protein sequence ID" value="KXB04665"/>
        <property type="gene ID" value="AKJ48_01780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.185"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="75" mass="8345" checksum="0FF1C0E2C3A2AA1B" modified="2016-07-06" version="1">MCLAVPGEIIDVTGNHATVDFGGAQREVRIDLLESVQKGDFVLVHVGYAIQLIDREEAEEMLKAWREVSEELPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE33</accession>
    <name>A0A133VE33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04713">
        <property type="protein sequence ID" value="KXB04713"/>
        <property type="gene ID" value="AKJ48_01645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="109" mass="12337" checksum="884D4BD4DD3E6824" modified="2016-07-06" version="1">MRGTIEQKVMGVDNMNAEVNGEILKIEIKATDGFDFGTSNEMEYKCKNCKNPISVEDGDVRALEKAVRVQRGGAECPNSFEAWWFCDMECFTKYCKRKVLHSLASKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE38</accession>
    <name>A0A133VE38_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04664">
        <property type="protein sequence ID" value="KXB04664"/>
        <property type="gene ID" value="AKJ48_01775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="242" mass="26895" checksum="BB0052E29ED11BE0" modified="2016-07-06" version="1">MPRVFGKEEFKMIPEFDFHVHTHYSDGLSEPVEMVEAATARGLRGIAITDHGPELSVGISPTKIEQMMNDVEIVNGDADIPVLLGIEANIIGLNGEIDIDEEILNRLDVVVGGLHNLASSAQIPKALAKDYLNTVMNTMKLQKIDILAHPFWFHEDLSKYLSQEDMEDFAKLAVRTGIAIELNTKYHSPSREVLTTCLREGVKLSLGTDAHTPSEVGDLTWQMSMIKKIGAKKEDLVLEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE82</accession>
    <name>A0A133VE82_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04758">
        <property type="protein sequence ID" value="KXB04758"/>
        <property type="gene ID" value="AKJ48_01500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="374" mass="43235" checksum="459F82BC52872025" modified="2016-07-06" version="1">MEELTYEARSDFGASWSSYYLYYTYPPMPMFIYYPFAQAYRLIHPTPSELSFAPAGVDPYPQVPLTLNLLWKLPIFLADIGIAILLLKMTNGSEKSMRMFLFNPFVIFISACWMFDSIAVFFLLLATYLFEQERYDLSAILLAFGFLTKYYPIFALPIFCLEFIRRKSWKFFRYTLIFGAVSFIFILPFLDGFTLGLGFQASRPPAGLTPFAAYPAFEHLGLIGGEGMNHLAYIALPALGAFTLITGMSLIYAYLSKKEMSLRTKLLLTFIVYLIVTKNVHEPYPFVLIPFFILLLHENFSKEKLWMYRLVWILPLMYAVFNVPITRFLYGFTLNEEILTFLVLPTTINAIILGSIMIVFHLTLWRALIKLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEA0</accession>
    <name>A0A133VEA0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_01440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04782">
        <property type="protein sequence ID" value="KXB04782"/>
        <property type="gene ID" value="AKJ48_01440"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.113"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="200" mass="22133" checksum="EB17367E872B50F2" modified="2016-07-06" version="1">MEKLSSGELDEKIRECTLCDLHKSRTNAVPGEGPDDADIMMIGEAPGYYEDQEGLPFVGSAGKKLDGLLEKAGLKRGEIFIGNVLKCRPPENRDPTTEEIETCRPYLERQIRTIKPKLIVALGRFAAGELLGKSVSVSREHGELRDSSYGGWHCKLFISYHPAAALYGADAAMKLEEDFEKLGEVVEKLDEFKTAEQTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEB2</accession>
    <name>A0A133VEB2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="7">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">leuS</name>
        <name evidence="12" type="ORF">AKJ48_01450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04788">
        <property type="protein sequence ID" value="KXB04788"/>
        <property type="gene ID" value="AKJ48_01450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.115"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="10"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="706"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="856"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="630"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB04788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="964" mass="111319" checksum="4C441D4DD5E9C08C" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEB5</accession>
    <name>A0A133VEB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04779">
        <property type="protein sequence ID" value="KXB04779"/>
        <property type="gene ID" value="AKJ48_01425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="142" mass="15845" checksum="6A71E998D753C068" modified="2016-07-06" version="1">MKTYSKEIEFATDKPRQVIDMTDKVLNVVRESGIKNGILIAQLPHATAMLALNENESGVKQDLLDKLNDFAPIDGGYRHDRIDDNAHAHLKAALVGSSRVLPIIDGRVIRGTWQSFLVIEQDGPRSRRRLVVTVFGESTTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEC9</accession>
    <name>A0A133VEC9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04810">
        <property type="protein sequence ID" value="KXB04810"/>
        <property type="gene ID" value="AKJ48_01395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="228" mass="25875" checksum="9987D4F77ED5EEE7" modified="2016-07-06" version="1">MLNASAAIFDTDGTLIDTTKRFYTVFCSMIKERGQEPLEWSEFFKHYSEDTLDEIISREAENREEELCDFWLEFLKRYRSIPIPDDYLIEDADVILEKISDAGAKIAVTTSCIIPPPKLEEELEDYGLMKHVDVVVTGENVIEDLVETHHFSKREIFEVALSELEVKPEDSVIIGDYWNDVKAGKELGAKTIAVLTGDMKPEILEDLEPDAILESVGDLFSVVKFSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEE3</accession>
    <name>A0A133VEE3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04822">
        <property type="protein sequence ID" value="KXB04822"/>
        <property type="gene ID" value="AKJ48_01260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="81" mass="9144" checksum="29821EFFA778CD99" modified="2016-07-06" version="1">MEPQLGQNLTLSERKARINKVKGRQMKEGLTPNALASIWRHLSGRVLPSSFLPFRIGDSTFTLLLIFHPASSVSLNRERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEF1</accession>
    <name>A0A133VEF1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Indolepyruvate oxidoreductase subunit IorB</fullName>
            <ecNumber evidence="3">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Indolepyruvate ferredoxin oxidoreductase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_01305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04828">
        <property type="protein sequence ID" value="KXB04828"/>
        <property type="gene ID" value="AKJ48_01305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017719">
        <property type="entry name" value="Indolepyruvate_Fd_OxRdtase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03334">
        <property type="entry name" value="IOR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="8">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="197" mass="21011" checksum="2265B414602A05F5" modified="2016-07-06" version="1">MKEASLVIAGVGGQGSIRASHIVAIAAIEDGLHARVGETFGAAMRGGSVASHVRIGEEIYSPLNPENGAEIILALEPMEGLRNAVKFLSKDGLFLTNTETWMPYDVSIGMAEYPSVDEIKKAVKKLGAEVIDFDATSLAQEAGNIRTMNVVMLGALDKTGKLPIKTKTLKKTIKENVPKGTEEVNMKAFELGAKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEG4</accession>
    <name>A0A133VEG4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04787">
        <property type="protein sequence ID" value="KXB04787"/>
        <property type="gene ID" value="AKJ48_01470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="113" mass="13077" checksum="4611F0F88DC840AE" modified="2016-07-06" version="1" fragment="single">REEYFYFYIKSTGIAEVAKLKLQDPDKENTINFLLNSNHSSGIHRKPGEMRRLLIELISRSEGATTWELSRQLKVRPSNVLTPLHKLSDDGIVKSESNGNNLYWSINNRSERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEI0</accession>
    <name>A0A133VEI0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04849">
        <property type="protein sequence ID" value="KXB04849"/>
        <property type="gene ID" value="AKJ48_01205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="72" mass="8283" checksum="737325D74DEF2460" modified="2016-07-06" version="1">MDDRFEQKYLVIPVKYQGAKLELRLGKRNTKRIKDEYGSNTEDWVGKQIEVDKIENYPGLGTKGLILRLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEI7</accession>
    <name>A0A133VEI7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04868">
        <property type="protein sequence ID" value="KXB04868"/>
        <property type="gene ID" value="AKJ48_01070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="3">
        <location>
            <begin position="194"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="397" mass="45802" checksum="442D24FEEE345771" modified="2016-07-06" version="1">MTQSPGGDNTSSNPTRRFDEPAQDNEEKQRYKFEREELRNLCQAARRIVYPEIKMNQHHNAEYSPSQILDVLTHAALTNDYTTNGSKTYGILGGDSPHPNSILYRVRKLELQEILNQFNSAVECTIREVRKRGMLRGRIDLAIDTTEWLYYGDENDPMVVKTRHRNGTNKAYRFATVNILINGERFTLKAIPMTQFTPREKILGELLDYAEKIVRIGIIYVDRAFFTVDCIRILQEKNVKFLMPAIKNKRVKGEMMSGVPRIVDFEYGVNRKDSVKFKLVVVEDEEKTSRAFATNLQVETVRAQELFELYSKRWGIETSYRVKSCLRPKTTSKNYEVRLFYFMFSVCLYNLWVLVNLLAGTRIGKDFGGLLVTAKMFCAAMCFPASAGEEGRDRPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEJ1</accession>
    <name>A0A133VEJ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argH</name>
        <name evidence="4" type="ORF">AKJ48_01275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04824">
        <property type="protein sequence ID" value="KXB04824"/>
        <property type="gene ID" value="AKJ48_01275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.905"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="3">
        <location>
            <begin position="362"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="491" mass="54075" checksum="4640D65AAE2A7053" modified="2016-07-06" version="1">MLRKGRFGGEMDPEASEYTSSMRDDVRLFDAIIRINAAHVKMLRECEIIEGSDADKLLDALSKLEKEGIEALDLSPELEDIHMAVEEYVSGEVGEEIGGKLHTAKSRNDQVSAAIRIALREEVLEIQEKLIELIKGLSEIAGKNTDTIMPGHTHLQVAEPTTFGHWLNSYAWPFSRTLEELNDDYVQVNSSPLGACALAGTSFPIDREMTSELLGFDGTVDNTIDAVGSRDFALQTMSSLAVLMTNLSRLAEEISLWSSTESDMIEVPDEFASTSSIMPQKKNPVVTEITRGKASRLIGDLMGGLNLMTTLPQSYNLDLQELTPLLWDAVDQSKSSLSIMAKLVKEIRPKPEKMLEHAEKGFSTATELADALVREADVPFRDAHAIVGKLVAGALKEGKELDDLKQSDLKKASKEIIGEEIKLSKKKLKKALDVGECIKSRALPGGPAPKSVKNELKKLGEKTKESEKIVEKRKKSLAKARDNLFKSWIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEJ9</accession>
    <name>A0A133VEJ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04872">
        <property type="protein sequence ID" value="KXB04872"/>
        <property type="gene ID" value="AKJ48_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="70" mass="8062" checksum="D4112F8E3C0D2468" modified="2016-07-06" version="1">MLRFLKSDSGLDLGENRVVEQERMTKFDAELWNSILIHDTETEVGEPFFGLLLCKNHNGFKLLPIKRVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEK4</accession>
    <name>A0A133VEK4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04865">
        <property type="protein sequence ID" value="KXB04865"/>
        <property type="gene ID" value="AKJ48_01055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="172" mass="18620" checksum="E9B2E6CBB9DC706B" modified="2016-07-06" version="1" fragment="single">LRENGFDESEVVVVHPDDLEKMVGPETEIVAIGGHDLLGINPPTSEFVELASTGPPYNRVKFLELLDNPVLENVDVVVGGKSAWQVADERVMGRLGIDYVHIGEGERSANLLNAPNNAPKVTSTKNTLPAPTQRAARRSKSRIGFHGIPEKTTAIATLNPQHAKNEFTPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEL0</accession>
    <name>A0A133VEL0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_01150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04883">
        <property type="protein sequence ID" value="KXB04883"/>
        <property type="gene ID" value="AKJ48_01150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="284" mass="30998" checksum="E7D8697575D4563E" modified="2016-07-06" version="1">MRRQTAWDWKITADTFLGGVGAGLFTSTLFLHLAGFLETEVRLGLLLGPILAILGLLFLLVEIGNPTKLHLVFNNLTSSWMSIGALIQGVFIISSLGYVLPNFEYFAWLPLEGVTIGLAIGLVAGISGILLLLYHGFLFSHSKGVPLWNTPVIPPLFLFLGLFTGLATLLLLEYGIGANVIVLQNIAKITMLNLIIEGVILWSLFTTSTSQAYKRSIEELKSPAKFGIIAGVGVIIPLFFLSLIAWMEIIEAGILAGVLALIGGFYTRHLILQEGRYYPSRIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEL2</accession>
    <name>A0A133VEL2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04882">
        <property type="protein sequence ID" value="KXB04882"/>
        <property type="gene ID" value="AKJ48_01140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.787"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="317" mass="35500" checksum="80A40301E5D0E3A8" modified="2016-07-06" version="1">MSTDLLYEENDVGIYAIDTEILGCPRGEACYLLKGSEEIALIDPSFPSSLNTLMNGLEDASLKIDDIDRIIVTHTHPDHAGVTSTLLQRNSDMRVSAGELAGRYLPKTATVGLPGAIMVFGEIAAREFGKIEDCPKDKIDVVEDGEKIDLGGIKLKAIYTPGHSPDHVSWYDEESGVLFTGEATCLRFPDLPVLIPVASPPKYDVSTALNSVKKLMKLDKPNNIFHPHFGEIPMDIEDYFQESLQRIGAWKIMIEDLFEERLNFKQIIQRVKNNVLKEAGKNPEDLPKTFRNFYLPTMLRIILMAYANVVLNEEMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEL8</accession>
    <name>A0A133VEL8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04893">
        <property type="protein sequence ID" value="KXB04893"/>
        <property type="gene ID" value="AKJ48_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="344" mass="39228" checksum="FC3BDBDC19FB9BB9" modified="2016-07-06" version="1" fragment="single">MIRRLSDYREVVDEAKISEIYRKGNKIADNHILHINSTYYGGGVAEILMHTMPLLDDIGIDVGWRSLVGSPDFFRVTKKFHNALQGEEIVLTDMKKRVYEQTNLSFAKFTHIDHDLVIIHDPQPLPLSKFYKRKQPWIWRCHIDLSEPQGEIWEYLRGFILPYNLVVYQMDEFAAQGVSGDYTIMRPSIDPLSVKNKDLPDGTIEKYTQKAGIDRERPLITQVSRFDKWKDPQGVIKVFDLIREEMDCQLLLVGAMATDDPEGQQVYEEVHSLIKDRDDIIVKIGAHDIMVNAIQKSSDVVLQKSIREGFGLSATEALWKKTPVVASNVGGLPAQVKDGETGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEM1</accession>
    <name>A0A133VEM1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S Mo/W bis-MGD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04881">
        <property type="protein sequence ID" value="KXB04881"/>
        <property type="gene ID" value="AKJ48_01135"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.786"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="905" mass="102787" checksum="CD02B68A42B29A65" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEM8</accession>
    <name>A0A133VEM8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04900">
        <property type="protein sequence ID" value="KXB04900"/>
        <property type="gene ID" value="AKJ48_01015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="105" mass="12197" checksum="849F4C37C2F4358D" modified="2016-07-06" version="1">MTEEKTPSVNMPRLFNVFDMPEVKSVRATTNIRMNVELKKILKNAPRARKIRTAGKKVVKFEINKGEYLLFFPSGYVQIHAPNEGRIREVLKAFRNELYECGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEP0</accession>
    <name>A0A133VEP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04874">
        <property type="protein sequence ID" value="KXB04874"/>
        <property type="gene ID" value="AKJ48_01100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="151" mass="17303" checksum="511E042AD56D80E0" modified="2016-07-06" version="1">MKDAGVLRHLKAISTGIKYLLFSKRQTCPYPEARQKVSEKYRGMIELDREKCTSCTMCARACPPNAIKMQMEEDKEMPCLDYARCVFCGYCVEVCPTNALEHKSLHDLAFRDYGEHKFPPKKLSEAGKDPYTIPKGEVKVKIDEKKGLLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ6</accession>
    <name>A0A133VEQ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04928">
        <property type="protein sequence ID" value="KXB04928"/>
        <property type="gene ID" value="AKJ48_00940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="99" mass="11546" checksum="0A86279B06F1021B" modified="2016-07-06" version="1">MLQIREKKEFIIKSHLLKVGNLEGGKMSGFKSEVDKKGRIVIPVEIRRELNIKPLSEVEVEIEEVIPRKSFVESARELREHVKEKEDAVKVLHEESPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VER7</accession>
    <name>A0A133VER7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04925">
        <property type="protein sequence ID" value="KXB04925"/>
        <property type="gene ID" value="AKJ48_00925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="77"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="391" mass="44321" checksum="407939857DA86B54" modified="2016-07-06" version="1">MISTLKGPIAMSDHENLEYKLVEIAEKIKSQGKKRRALAKILRRVKDELELPIDEENQEVTETKLVTQTGLNPLSNDTIAGVDGGVLARPLHGLDLILVRAIATVFHYEEGSLKQAEYHPNEVPWPELMSIHEPLDSREFELLVGMYRQLTELKRAKEAIENWSMDTLLLDGSIVPQYTSHASKSRTRELYRELVDSFTNLYQTCVKKNVLLLGVVKDSRSARLIDIFQRNILPDLDACTNLSPREIASLEDNRSVLLDSRDTVFLDHLLDPGERSFVFRYADAPANLLQDIGDWRNRIHAFYVKTVPYDRPLRIEFVSFPEKVSQTADGASSLIHALSAHHDACALPSVLIEADACARLAQEEISMIRDSITDRLEPSTLLDLRRERGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEU4</accession>
    <name>A0A133VEU4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04955">
        <property type="protein sequence ID" value="KXB04955"/>
        <property type="gene ID" value="AKJ48_00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="99"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="383" mass="42550" checksum="988D2D01D876DA3D" modified="2016-07-06" version="1">MRVLILESISGLRQKIEPRLFPEGFAMLRAMTNEFSEAGFDVTSTLNRGIRDFEDWLNVDELLHNDELDSAIKPKPDAALIIAPDAEGELEQITNKLREKRIPVLGAKGSSIRISRDKWKTHNTLKQKVPQPTTWKIPPNAGESLVAKQRQGAGCEGIHLTSNRIHSPSGGMIFQEFIEGVHASSCLLTKGGESSVLSVNKQMITQNNHFKYWGGEIPFENEQMEAQIEFSRKAAEALDLDGYCGVDFVIGDVPYFMELNPRITTSFVGLAPILQANLGELLINTLIEDNSPLKPRLRGCSIIKIPRVLRNVKLDVDKLKKLKQIPEIISPPFAPNGRLAKGSPLFLAVGCDSNSRKAERKLESKIKRAISSLGVDLNAVDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEU6</accession>
    <name>A0A133VEU6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Molydop_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04947">
        <property type="protein sequence ID" value="KXB04947"/>
        <property type="gene ID" value="AKJ48_00790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012040">
        <property type="entry name" value="Formylmethanofuran_DH_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015873">
        <property type="entry name" value="FwdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molydop_binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="126" mass="13887" checksum="DDD25E853F7CBF19" modified="2016-07-06" version="1">MWFNLITGRTSDQAKGLEHGKTTQEYRESAAVVFLNDKDMEELGLDENSPAKVTSEFGSVTVKSKRRDLERGVIFMPLGPWSNMLIGGDTKGTGAPQTKGVKVEVSKSDEEILPMEKILKLAEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEW9</accession>
    <name>A0A133VEW9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_00635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04986">
        <property type="protein sequence ID" value="KXB04986"/>
        <property type="gene ID" value="AKJ48_00635"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.392"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="353" mass="39643" checksum="0FCCDC90C38F4021" modified="2016-07-06" version="1">MITLTSILEYIIPLLIFAAFVIAGQILKVILDVYVARFAKRTETKLDDILLDALRTPILAIFALAGVEVALLYTTLVPTGIAQWIHPLIFFGIGIIAIFGVTRALSGLTTHYGEKYPGIQPLVPVLRKLIKILVWFVGIMVILAWLGISISPLLVSFGVGGLAIALALRGTLENFFSGLHIMLERSVKHGDYVKLQSGEEGYVQDIGWRTTKIRMLPNNMVVIPNSKLAGTIITNYYSPEQEMSTLIDVGVSYDSDLRKVEEVTVDVAKKVLQEVPGGVEDFEPFIRYHTFDDFSINFTVILRVKEFVDQYAVKSEFVKALHERYEEEDIVIPFPIQTLEWRKRKEAPEEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEY2</accession>
    <name>A0A133VEY2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04995">
        <property type="protein sequence ID" value="KXB04995"/>
        <property type="gene ID" value="AKJ48_00685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="78" mass="9080" checksum="F6BFA0B66E767321" modified="2016-07-06" version="1">MKKTKIIEVLKKSGKPLTIEQLSEKTGVPVPRLRMDLFRLQGEGEVESRQKGDELLWTIKVAKPVEERYEKMRKKPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEY5</accession>
    <name>A0A133VEY5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="6" type="ORF">AKJ48_00735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05008">
        <property type="protein sequence ID" value="KXB05008"/>
        <property type="gene ID" value="AKJ48_00735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.413"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="5">
        <location>
            <begin position="190"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="195"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB05008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="408" mass="44414" checksum="66C47526371A9BA4" modified="2016-07-06" version="1">MLHPSKNIKSSEGSDLANQNIVLCITGSVAAVKCMELARKLMRQGVEVKVVMSEKATELITPQLMHWATGNPVTTELTGAIEHVELAQWGDLVLIAPSTANTLSKVACAVDDTPVTSVVSVAQGLKKPILIVPAMHESMYSHKIIQDNLSRLKEAGIQVLEPKLEEGKAKLPEVEEIVNLVKSLLHPKDLTGKKVLVTAGPTLEKIDPVKIITNKSSGKMGIEIARAAEMRGADVTLVYGTGTETPPPAIKTLRVETTSEMQDRIRDELQGNYDVFVSAAAPQDFTVENVSEDKLRHSEPINLKLVPAPRIVDEVRERSPETFLIGFKAEYEVSDEELEKAARGKMEESQLDMVVANDLARSGAGFESSTNDVLILSKSDLKRVKSSKLAIAHTIFDLIADELEGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF07</accession>
    <name>A0A133VF07_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04994">
        <property type="protein sequence ID" value="KXB04994"/>
        <property type="gene ID" value="AKJ48_00680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="122" mass="13609" checksum="D16E8712F8767B3D" modified="2016-07-06" version="1">MMIKKDKIDELASVLLAGGKMLSQHCPKCKTPLFEYEEKIICPVCGGEVVEEETTPKERDSGSGEVVAKAEGKPATELKRIAQNKLAQLEDKLEDENDPEKVNEILKAIKSTLDVLERLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF12</accession>
    <name>A0A133VF12_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05025">
        <property type="protein sequence ID" value="KXB05025"/>
        <property type="gene ID" value="AKJ48_00450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld5" evidence="2">
        <location>
            <begin position="31"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="195" mass="22587" checksum="14715660A8C52B3D" modified="2016-07-06" version="1">MKQKVKSAQKLPEINLVGRKIGPLSAGEETHIRPWEAAILERRGFIQPMDEYTPAGLRKRVLAEGRSSDLKDLPECFYETLNHRIQILQSEDRFDEVKKMREALNSLIDMRIQKITRMATSPVSAKKLPPEEQFLVNHLSELIKNWKKRLDNLFEKIPEEEVGAREERVRRAIREIVGDAANIQKQRIPSTDVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF39</accession>
    <name>A0A133VF39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05037">
        <property type="protein sequence ID" value="KXB05037"/>
        <property type="gene ID" value="AKJ48_00535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="147" mass="16663" checksum="A87D8A36F585C274" modified="2016-07-06" version="1">MDKLNEQNLKTIKMYSIVSVFSPIIIMIFPSTSSTEIPGMVNEGFNFFVEGLSFPTVLLFFFVEGLGYLIALFYLYNRFIRGGRRFSVDLFQNFETLVIDKGYNEKIAAGVRRTGSILRKMHRGDLSTYLLWAVLGLLIIIAGIALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF45</accession>
    <name>A0A133VF45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05066">
        <property type="protein sequence ID" value="KXB05066"/>
        <property type="gene ID" value="AKJ48_00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="137" mass="15752" checksum="B354B348FDC05486" modified="2016-07-06" version="1">MGEGANIYSGSKDLDGLAAALTNPTELSYKKNNIKKHYPVEFRGQEYRDAEAAFWKHAEDKELSFEEQQELCTEVVTAKLEQYPELVEAINQQGGVEWLEKCRHFTGARTEKFKKWEGKGKDSAFIRCLINAYKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF48</accession>
    <name>A0A133VF48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05069">
        <property type="protein sequence ID" value="KXB05069"/>
        <property type="gene ID" value="AKJ48_00380"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.71"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="518" mass="56749" checksum="201384943F72B816" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF54</accession>
    <name>A0A133VF54_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05071">
        <property type="protein sequence ID" value="KXB05071"/>
        <property type="gene ID" value="AKJ48_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="270" mass="31803" checksum="0BDD4D3236999BC8" modified="2016-07-06" version="1">MKSILTVKVKIRKDDRLIKTLRIYTRAIQFAINTAWRLGLKTRRRIHDECYHEIREKFKLQAQLAVCVISQASEMINNNPKSKPQVGKHATIRYNFPRSATIKGDWRELSLATVDGRVTVNLDIPEYYQKYLNWEVRESNLLFRSGELYFYFTLAKEVDTRPKRDDFKVLGVDLGVNKIATTSDGDFYGKEVKRKRGEKDRFVAELQAKGTHAAHNRLKAKSGEWKRFMTWRNHVISRRIVDKLDEGDVLVMEDLKNIRRTAKYNEWVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF58</accession>
    <name>A0A133VF58_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05079">
        <property type="protein sequence ID" value="KXB05079"/>
        <property type="gene ID" value="AKJ48_00440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="106" mass="12312" checksum="0E8CDC1F4BCB1C2D" modified="2016-07-06" version="1" fragment="single">CEDLSLSKSVKAEVSSLYRKAKVAWVTPGRDTWSVLSALIFIVLRMRRISRTEKEIAQALKVRTETTESKALHDLRNIRKTITRELELEIPRPRPEEYLGRYATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF63</accession>
    <name>A0A133VF63_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05070">
        <property type="protein sequence ID" value="KXB05070"/>
        <property type="gene ID" value="AKJ48_00390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.73"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="2">
        <location>
            <begin position="247"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="381" mass="41415" checksum="466882C0939FE95C" modified="2016-07-06" version="1">MEVGIASYGHTKYGVLEEDTPDLIKKVMDDCMNNVENGISPEEIDRIIISCVDNAFSEQHQTGTLGWEYLGNPDAFGFKVESACVSGSVAVYRGKKMIESGEAENVLVVGFEKMNKFSTDKVTEFLTHGSSPEERKYGVTQPGAYALLINLYAQKYDVTEEDWAEISVKNHENALRNPWAHFHKEITKEGVMDSRIIADPIRLFHCSTVSDGAASLLLSANPQEYTDTPVYIRGMGVGHDYLSVADREDPTFLLCSKRAADQAYEQAGKSPEDVDVAEVHDAFTPVEPLCYEAVGFAEKGEGAKLVREGTVMFDGSLPINTSGGLKAKGHPVGATHVGTMVEMYLQLRGEAGERQVPDPETALIEGHGGTGSVAVVSVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF65</accession>
    <name>A0A133VF65_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05081">
        <property type="protein sequence ID" value="KXB05081"/>
        <property type="gene ID" value="AKJ48_00385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.72"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="246" mass="26812" checksum="EF8D71A4546AE551" modified="2016-07-06" version="1">MEKEVETAIVTGASRGIGKAIAFELAQNGFNVVISDIEKTDGCEENIENIDELGREAIFVKADVSDRDQVEDMVEKTIEEFGRVDVLVNNAGINIDKMLTNMAPEQWQKVIDVDLTGVFNCTQAVLPHMIQQGGGKIVNISSMSALDGTPGQANYASAKGGVISFTKTIAMEYAQHNIICNAIAPGFIKTRMTDEMPPGLFRNRLKENPLGRRGKPEEVAKLVSFLVTEGDYITGQLININAGEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF86</accession>
    <name>A0A133VF86_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05103">
        <property type="protein sequence ID" value="KXB05103"/>
        <property type="gene ID" value="AKJ48_00090"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.17"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="244" mass="26421" checksum="31DB13F49C325B66" modified="2016-07-06" version="1">MPKIKPKQAQTIGVFSCKGGVGKTTTVANLGVALSESLEGDVLLVDANLTASNLSIHFGELDPSPTIHDVLAEEKSIDEVTQDVDGVDAIYGSMAFGEEIHRVDLKGCLDPLKKKYKLILLDTSPGLGSEVISSIKDCDEMLILTNPDTPTVASTLKTFRAAERYKVSIWGTVVNKVLGQDYELSPKDIKKALGWPIVANVPDDDRVRESTAEGIPIVKFELESEAAKEFVELAEKLEEHIKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF88</accession>
    <name>A0A133VF88_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05109">
        <property type="protein sequence ID" value="KXB05109"/>
        <property type="gene ID" value="AKJ48_00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="195" mass="21871" checksum="7908396C2AE69617" modified="2016-07-06" version="1">MRLKTLKYRITRGQKLECGCAPMKDPATIPGEGILHPTPRILFKKASGTQDAFSWPTPASKFMALLITFSLVVGMMLVFTPSASAAPGDTSENIGATMKSGENQHGYSLILLGSTITRVQIFVSHKTPRAEINVRELEAPRLELKIYPPLHNRFLRSPPILRRIMRYSVQQSNSKYRNLGWNRMGLVRIPSSYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA2</accession>
    <name>A0A133VFA2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05128">
        <property type="protein sequence ID" value="KXB05128"/>
        <property type="gene ID" value="AKJ48_00255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="145" mass="16361" checksum="DB030AF5F9A89E7B" modified="2016-07-06" version="1">MKIPERIMIDADLFISYLTEDELTPKFSKVVERANRGEVKLLATSELYDDVISALRSQKIGLDKILDFLSDMRAIPHESIPVTIGIARKALHLYSQHKGSRKLHYFDSFHVAAAGQQDLPLLTSDKYIIKHTTDLGIGVINAREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB1</accession>
    <name>A0A133VFB1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05094">
        <property type="protein sequence ID" value="KXB05094"/>
        <property type="gene ID" value="AKJ48_00030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="156" mass="15916" checksum="23CB7593A2AB4DA0" modified="2016-07-06" version="1">MKKEGLVAGALSVFVIALIAVGSLSIAISYKRVIGPTLILLGFFSMIPLKIFGRTIKSCAADIIFGSIDTSFLGIAALTGAHFAGVLGAIVGGAAGDAITDGFAGLWEGKVAQYLRAHGIREARTPLSASMGKMAGCFMGVGIVLACVWTIGALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB4</accession>
    <name>A0A133VFB4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05132">
        <property type="protein sequence ID" value="KXB05132"/>
        <property type="gene ID" value="AKJ48_00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="201" mass="22522" checksum="CB71FDBBF6DD372E" modified="2016-07-06" version="1">MQLSAYNEENRIKPVIEETKKHVDRVIVIDDGSFDRTAEVSRKAGADVLVHKDNKGYLKALKTGFNKAQEGIVITIDADGENDPKFIPELVQPILKEKTDLVLGKREHVPRVSERFISFITSPVVDVSDTGTGFRALKADLAKKLDLEGLCPCGTFVLEAKKLGARIEEVPVKARRVDKPKKIAWKHLPQLWYVAKALIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFC2</accession>
    <name>A0A133VFC2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="4">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="4">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">folD</name>
        <name evidence="7" type="ORF">AKJ48_00265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="4"/>
    <dbReference type="EC" id="3.5.4.9" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05130">
        <property type="protein sequence ID" value="KXB05130"/>
        <property type="gene ID" value="AKJ48_00265"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.48"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="6">
        <location>
            <begin position="120"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB05130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="282" mass="30988" checksum="141EE414BA9FBED5" modified="2016-07-06" version="1">MMAVVMDGKELAQTIKREIMGKVESSDITPGAASVLVGDEPSSKKYVELKGKDCRSVGINFQTHQLPKDVSEEELLGLIDELNEDSEIHGIIIQLPLPQKLSAEKVIMRVDPAKDVDGLHPYNVGKLWLGDYELERDLVPSTPKGIMELLEHYDVEIQGKEAVIINRSNLVGKPLAKLLLDKNATVTTCHSKTKNIEEHMQRADILVSAVGRRPEFQITENMVKEGAVVVDVGMSYINDKLYGDVDFEEVKGKTSHITPMPGGVGPMTRVALLQNILIAAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFD2</accession>
    <name>A0A133VFD2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">KH type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05135">
        <property type="protein sequence ID" value="KXB05135"/>
        <property type="gene ID" value="AKJ48_00055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="59" mass="6545" checksum="20B6846329546E1A" modified="2016-07-06" version="1">MEKLKRMLDVDIDRVEEDGNKVIVFVPEGQAAKAIGSNGCVVRSVELVLDRELEVKESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFD5</accession>
    <name>A0A133VFD5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase DegT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05140">
        <property type="protein sequence ID" value="KXB05140"/>
        <property type="gene ID" value="AKJ48_00310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.57"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="371" mass="41251" checksum="6200AA8AA9B933D2" modified="2016-07-06" version="1">MGEDFIPIANVELSDDEIQAAVEVLKSGYLRQGPKTKEFEEKFAEKVGSEHAVAVSSGTAALHIAYLALLDSGDEVLVPSFSHISTASMVSFANCKPIFCDLDPRTFTLNLESTEERLTEKTRAIVPVHLFGNACDVDEITDFADEHELRIIWDAAQAHGTKYKGKDVGSFDDLVCYSFYPTKNMTTGEGGMITTNDSKINEECRLLREHGQVKKYFHTTLGLNYRMTDVEAAIGIRQLEKLDDFVSERRGNAEQLTEKLSEIDGVTPPLVKEGIKHSYHQYAILLDLDELECTRDEFIESLNKKGIGTAVHYPRPLHKQPIFQELLGDSPLPTSEDISKRILSLPVYPGLGEGDLERIIEGVRAIVKTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFE5</accession>
    <name>A0A133VFE5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05134">
        <property type="protein sequence ID" value="KXB05134"/>
        <property type="gene ID" value="AKJ48_00300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="101" mass="11870" checksum="23C2A6F397CFCC57" modified="2016-07-06" version="1">MTTKTQIATRVDKDLLAQIKEIEREMKADRAEVIRRLLDEGIKQRQLDKAMTMLRNDKVTVSKAAEIAGVSIWEMIEVMREKQIPIPYDEEDLRKSLKWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V916</accession>
    <name>A0A133V916_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000098">
        <property type="protein sequence ID" value="KXB02948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02948">
        <property type="protein sequence ID" value="KXB02948"/>
        <property type="gene ID" value="AKJ48_04385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB02948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="138" mass="15573" checksum="61AA77D58525D1BF" modified="2016-07-06" version="1" fragment="single">GRKVEVDLGGFRGIPVSSRMKERVESAPIGGLDKLRLMLISNEDNIIFKSMGEREKDYDDIHSIISNPIDWGVVLEESEKLTRETLTSGETPTLFPGFIAVSLREVMEKHGGVSEDIIKKFEQSAIRLNEVLRRETKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V965</accession>
    <name>A0A133V965_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_04380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000097">
        <property type="protein sequence ID" value="KXB02959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02959">
        <property type="protein sequence ID" value="KXB02959"/>
        <property type="gene ID" value="AKJ48_04380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB02959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="598" mass="65133" checksum="C98D85F3AE16115E" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V972</accession>
    <name>A0A133V972_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000092">
        <property type="protein sequence ID" value="KXB03020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03020">
        <property type="protein sequence ID" value="KXB03020"/>
        <property type="gene ID" value="AKJ48_04305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="137" mass="16477" checksum="0ACC58438E2C7893" modified="2016-07-06" version="1">MREHEADTVIAFNAPFDFRFIRTRALILQERKPLAGYYMFNEKSWLKSFTRFRRYSLDYVAKELGIGEKVGKGHQMPMLYWKGETNKIVKHCRKDVELLIRVHERCLEVEKGKKRITVIKESEPSKEKKEEKIPRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9G7</accession>
    <name>A0A133V9G7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000089">
        <property type="protein sequence ID" value="KXB03071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03071">
        <property type="protein sequence ID" value="KXB03071"/>
        <property type="gene ID" value="AKJ48_04250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="61" mass="7036" checksum="29B988FEBB7752F7" modified="2016-07-06" version="1">MVKMSVEIGKDVIDGLKRAISRYESYSFTKLGRMTTDDLVEALETIEPSEEREKELEKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9H2</accession>
    <name>A0A133V9H2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000088">
        <property type="protein sequence ID" value="KXB03086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03086">
        <property type="protein sequence ID" value="KXB03086"/>
        <property type="gene ID" value="AKJ48_04240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="344" mass="39904" checksum="52E56826F87A98A2" modified="2016-07-06" version="1">MAEHGYSRDKRPDKLQIVLGLAVDQQGILITHSVFPGSTADIATIEEMSERLEKEFSIPEMLLVVDQGLMSGEKMAFLDEKGIDYLVSMGSRKKAIDQAREREWQSVDEKTRAAMLKFEENGRTKRYIVGYNKDMAEDDKAYRNSRTRRAKERLKAIKAAVEKGKLKRETKIAERAGKALERVKKYFHVEYGEGYFDYWLKEEVVEREEFYDGYYVLLTTREIKAGEAITAYREKDRVEKAIRCIKSFIDLRPTYVWKDLRVVGHVFVCMLAYQLRSVMNYILNEEKMGMSVEDALEYLQRIKVAELLFQRDGVVAVRKVTTLNKKQVALAQVFNIKNAMEIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9K1</accession>
    <name>A0A133V9K1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_04220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000087">
        <property type="protein sequence ID" value="KXB03101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03101">
        <property type="protein sequence ID" value="KXB03101"/>
        <property type="gene ID" value="AKJ48_04220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.894"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="91"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB03101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="314" mass="34701" checksum="174BB60C032D00A3" modified="2016-07-06" version="1" fragment="single">GPQFIVNISNFLDQGELKPGARVGLNQRTLNVMKILPTEKDPFVRGMEIEESPDVTYKDVGGLKKQIREIKETVGLPLLKKEALEKVGVEPPHGVLLYGPPGTGKTLLARAVAHETEATFIRLIGSELVHKYVGEGARMVREMFDFARERAPSIVFIDEVDAIASSRMKTSTSGDREVHRTMMQLLAELDGFEPRGNVKILAATNRPDILDRALLRPGRFDRLIEFPKPDKEARAAIFEIHTRGMSLGKDVNLEKLAKLASGVTGADIKAICTEAGIRAIRKDRDAVNPEDFKKAIQKVLTETEKPDIPGVMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9S6</accession>
    <name>A0A133V9S6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000082">
        <property type="protein sequence ID" value="KXB03186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03186">
        <property type="protein sequence ID" value="KXB03186"/>
        <property type="gene ID" value="AKJ48_04140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="104" mass="11942" checksum="FD829B1517D2C4DC" modified="2016-07-06" version="1">MSKVDDELVEYVSRPTRSILSRKLVNYFRSMRSLARKLGGSEKTVRNWVKTDGSHPSNELTRKIIRASLKENPGLTLTILNNDLLKHQATIKRLFEQLSEDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA42</accession>
    <name>A0A133VA42_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000075">
        <property type="protein sequence ID" value="KXB03312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03312">
        <property type="protein sequence ID" value="KXB03312"/>
        <property type="gene ID" value="AKJ48_04010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003748">
        <property type="entry name" value="DUF169"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37954">
        <property type="entry name" value="PTHR37954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02596">
        <property type="entry name" value="DUF169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="338" mass="37345" checksum="58A0A83573F7D806" modified="2016-07-06" version="1">MTNEELSDQFRKFFQLPSSPVAVKISEEGLDGPRPESSSRFCDFVRTVAYEGKKLVITEDDLSNFTAAVILGFTEPKYVDISPRIKPAKTKSIELTPLEESEGEPDVIVTITNPARMMEIVQILHQTTKKRLESSMTCAGSAIAGEATALPYMDGSSNLTLLCGGARTIGGYQEEELAIGIPFSTFAELAGSLTEPSLTDALCGCLMDDIPDHVEETFADMGFESGTDHFFGEFEDKTLRFYVDKDEKGTLSIMTVHYPLKLASEEQARTAKKIAEGLLAGRGMAITRENWLDLVLKTTFDRGLEKEALDKKEFQKNLSQIFSDFVKISDKVKEEASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA79</accession>
    <name>A0A133VA79_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000074">
        <property type="protein sequence ID" value="KXB03334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03334">
        <property type="protein sequence ID" value="KXB03334"/>
        <property type="gene ID" value="AKJ48_03995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="98" mass="11514" checksum="47F8D78A6DA6BAC1" modified="2016-07-06" version="1">MKGSIIVYQTSNLSRHKATKFSRELHGYKDRSNKGRYVYHRPGLLDEIPSRELIRGAVIIKRRDLDKVLEFMKSYDAKVYARTVELTARDEEILKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA92</accession>
    <name>A0A133VA92_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000074">
        <property type="protein sequence ID" value="KXB03335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03335">
        <property type="protein sequence ID" value="KXB03335"/>
        <property type="gene ID" value="AKJ48_04000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="158"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="351" mass="40443" checksum="A4644BA1ABF9A553" modified="2016-07-06" version="1">MGRTNPRQKILDEYIEGLKNKEIEYVPRGENEHPINWSKYDEAQVNELRDMLVHIRDVVDVAVMRLDLEETKAERGRPPYPAGDLAKGILLQQYFEVPNRVAAGFVDLFKEKLGIESSYSYKTLERAYDDPHVIMILREVFKMTQEPVRDEEKNFAPDGTGIPTALSVNWARDSEDNEKKYEFLSMIAMMGASHHLISAVEFPDNPAAHESPYFEPLLKGTDTSYTSIGKVSGDAAYLSRDNCDLVESLGGTPRFYPKEGITLKMRGSSGAWTDMLLDFIDDPQQWLRDYHSRSNAESVFSAFKRKFLAPLRKFLHLRRKAEAFTRVCDYNLRRLAQLRRLKNIKVPWLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAE7</accession>
    <name>A0A133VAE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000070">
        <property type="protein sequence ID" value="KXB03429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03429">
        <property type="protein sequence ID" value="KXB03429"/>
        <property type="gene ID" value="AKJ48_03900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="107" mass="12550" checksum="D82F521CD6625EF6" modified="2016-07-06" version="1">MRTRFDGLSEFLSRRGRMKLLQILRDDNQSYEQIAQCLDVNRSTVYRWFHDPQKHPSNKTTDKIIDLAKLSSPKALKAVLIEEITKFINLANKRLELVSRCQVQMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAI9</accession>
    <name>A0A133VAI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000071">
        <property type="protein sequence ID" value="KXB03407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03407">
        <property type="protein sequence ID" value="KXB03407"/>
        <property type="gene ID" value="AKJ48_03925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="108" mass="12108" checksum="7647B61A1410BB51" modified="2016-07-06" version="1" fragment="single">MRVEELEELFHDIDEQLDQETTLFTIGGAPMLFREQKPATKDIDLIASSETDQESAINALKELGFRLPSIGIDYEDLRGRKVEVDLGGFRGIPVSSRMKERVESAPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAQ5</accession>
    <name>A0A133VAQ5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ribofuranosylaminobenzene 5'-phosphate synthase</fullName>
            <shortName evidence="1">Beta-RFA-P synthase</shortName>
            <ecNumber evidence="1">2.4.2.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:82767"/>
            <dbReference type="EC" id="2.4.2.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-RFA-P synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.54" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000066">
        <property type="protein sequence ID" value="KXB03523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03523">
        <property type="protein sequence ID" value="KXB03523"/>
        <property type="gene ID" value="AKJ48_03810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004422">
        <property type="entry name" value="RFAP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF6">
        <property type="entry name" value="PTHR20861:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004884">
        <property type="entry name" value="Sugar_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00144">
        <property type="entry name" value="beta_RFAP_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="2">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="343" mass="38122" checksum="2D438CBCFD842B08" modified="2016-07-06" version="1">MIGRIGGVNIRIRISSPSRLHLGDIDPFGLGRFGYAILVGIEFPRTVIEVKESDSIEIEFEKSRNWSGVEENEREEIRRYAERTLNNLGAPGAKISVISHPPRHYGLGSTTQLSLSVGLGIFLAYGKKASHSKIMKILKRTSAGGIHTFERGGFVVSGGFEFPRKRFRISNQEKPVFPPLILRKEFPEEWRFVVAWHRKAPPGPSGEEEENAFEDLQDLEPPKELIHEAHFLINTKLVPAVLEKNPVKFGEALTRVQTLVGELYSPVQTGTYNPASAPLLEQLSECEESLGFGQSSWGPAVYSLARDENAATKIIKETLKTTNAEIHAVGADNKGRQIEILES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAR2</accession>
    <name>A0A133VAR2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000067">
        <property type="protein sequence ID" value="KXB03495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03495">
        <property type="protein sequence ID" value="KXB03495"/>
        <property type="gene ID" value="AKJ48_03830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="127" mass="15002" checksum="ABBBA7DED15F8AF6" modified="2016-07-06" version="1">MDKEQVKKDFEFLKDDERVLSVLVFGSQITGRTHERSDIDVCIVAPDADPWGVLKQVFSKIDTEKKNYDVHVFEEFTLRLKHYVMENYETLWTRDKSELETYFYSHRKLWNDQAKARGVAASPTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAT3</accession>
    <name>A0A133VAT3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribulose bisphosphate carboxylase</fullName>
            <shortName evidence="1">RuBisCO</shortName>
            <ecNumber evidence="1">4.1.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbcL</name>
        <name evidence="4" type="ORF">AKJ48_03785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2R)-3-phosphoglycerate + 2 H(+) = CO2 + D-ribulose 1,5-bisphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:23124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="4.1.1.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 1,5-bisphosphate + O2 = (2R)-3-phosphoglycerate + 2-phosphoglycolate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuBisCO large chain family. Type III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.39" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000065">
        <property type="protein sequence ID" value="KXB03553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03553">
        <property type="protein sequence ID" value="KXB03553"/>
        <property type="gene ID" value="AKJ48_03785"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.745"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01133">
        <property type="entry name" value="RuBisCO_L_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017712">
        <property type="entry name" value="RuBisCO_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000685">
        <property type="entry name" value="RuBisCO_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036376">
        <property type="entry name" value="RuBisCO_lsu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="PTHR42704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00016">
        <property type="entry name" value="RuBisCO_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00014">
        <property type="entry name" value="RuBisCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51649">
        <property type="entry name" value="SSF51649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="SSF54966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03326">
        <property type="entry name" value="rubisco_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuBisCO_large_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RuBisCO_large" evidence="2">
        <location>
            <begin position="134"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="343"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB03553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="415" mass="46447" checksum="3865B6AA6B0CD422" modified="2016-07-06" version="1">MRGMRYEDYLEESYEPQETDLVCEFRFEHDPSVSFEWAAGAIGAESSIGTWDPHLSTMREEIRELGAKVFWTDKEDNRVKIAYPQDLFEPRNMPQILSSITGNIFGLSELTRLKLLDVNFPEEIINGFSGPQLGISGVRELTGIKDRPLLGTIVKPKLGLSDEQHSTVAYDAWRGGVEIVKDDENLADMSFNRFEDRIPKTLDKRDEAEDETGEKKLYFPNITAPLSEMKRRADLVIDHGGEYVMIDILTTGWSALQEMRDYLEGKGIGIHAHRAQHAAYTRLEDHGISMLAIAKFARLVGVDNLHAGTIVGKMEGEKQEILNIYDSLRSNFHDLKRTIPVASGGLHPGLVDDLIDIFGTDLVTQAGGGIHGHPDGTESGARAMRQAVEARTQGIELQDYAEDHPELAKALEKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBC9</accession>
    <name>A0A133VBC9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000060">
        <property type="protein sequence ID" value="KXB03730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03730">
        <property type="protein sequence ID" value="KXB03730"/>
        <property type="gene ID" value="AKJ48_03665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB03730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="97" mass="11467" checksum="17CAB4A6EFD450EA" modified="2016-07-06" version="1">MKTTSFRLNEKELERIQELAERESKEKSEVMRRLIDSGWEYLMIKRYARGKISLGRLAKELDLSITETLDILSELGVKAQIRREDIQQGYETLKAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBV1</accession>
    <name>A0A133VBV1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoCF_biosynth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000056">
        <property type="protein sequence ID" value="KXB03928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03928">
        <property type="protein sequence ID" value="KXB03928"/>
        <property type="gene ID" value="AKJ48_03580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="174"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="324" mass="35348" checksum="8256B57163BA76C5" modified="2016-07-06" version="1">MKRVRVENSIGKPLAHDVIQYGPGVKRVLFTRGHLVSSEDLDELKDTGNYYVYISEGEDDKGVHEEEAALRIAQAAAGGNISLTKPDKGRVRLVSESPGLLKVKSEVVKQVNLEDDFVLATRLNNSGVRKNQEVASTKIVPLVIEEGKLERVEKILGDNKPVIEVIPPKIEKIGVIIAGKEVYEERIEDAFKPVLEEKLKPYGLTITKSIILPDDEEKIKEKIIEYKNGGLELILVTGGMAVDAGDVTANAIRGTGARVIPRGTPIFPGNMAMVAYLEDVPVLGLPACVIPDPQTSFDFFLPRALAKEEITNEDIAELGHGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBX9</accession>
    <name>A0A133VBX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000055">
        <property type="protein sequence ID" value="KXB03956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03956">
        <property type="protein sequence ID" value="KXB03956"/>
        <property type="gene ID" value="AKJ48_03565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="157" mass="18329" checksum="A721F23473344DF8" modified="2016-07-06" version="1">MSNSPLLKGLRVSLCSFWVIPSPLRNFTLSISQIRLLEKQPFEILLLDMEVDNVESLFELRKIIPRLFQTKDMRLEEEALDDLTRRPNCAKIVRAILNLGDSPDTVTDELVERVAEYMKMEDEPPENLKEIEILQEEEEAKSYVENPAERRSRKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC10</accession>
    <name>A0A133VC10_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000055">
        <property type="protein sequence ID" value="KXB03955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03955">
        <property type="protein sequence ID" value="KXB03955"/>
        <property type="gene ID" value="AKJ48_03560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="162" mass="18229" checksum="267F353EB6E27958" modified="2016-07-06" version="1">MLVFPLKKITAPRRLKYELGPKWTRSSDSLYFPVISARIMKGDGTYSEKLLSFILDSGAMMSVLSKKLAEHLNLETFGKCEISGAVLKKECRIPAKLSKIKMKLVDERGKLSPELNLTAAVPEIDEVPSVISLNDLMGRFEISMNSREKKINFILFEENSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC27</accession>
    <name>A0A133VC27_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000053">
        <property type="protein sequence ID" value="KXB04008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04008">
        <property type="protein sequence ID" value="KXB04008"/>
        <property type="gene ID" value="AKJ48_03490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="493"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="575" mass="63316" checksum="A5B45589456EFDD6" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC39</accession>
    <name>A0A133VC39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000054">
        <property type="protein sequence ID" value="KXB03977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03977">
        <property type="protein sequence ID" value="KXB03977"/>
        <property type="gene ID" value="AKJ48_03510"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.664"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="300"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="395" mass="44594" checksum="BEA85BD896F3DA5C" modified="2016-07-06" version="1">MSEEYESRNVRELLTEMKDVSDITIDLAYASLQFENEELAEQVIELEELMDELMYQIRTLVSLSVRSVDDAERTTGILQVADAAEEISNATGDLADIVLRDIEVHPVIKSALKKANEKLSQVKVRKDSEIDGKAFHELKLPSRLGVWVLAIQRGEKWKIAPTQEAKVKAGDLLIIRGPQEGIDTFCEMASAPERDWRIGKKYRRLKETLARMRDTGCLMVDMAYSSALFKSVEVAEEVREVEEQYDELNYAVWREVLKAAKREKDVTKLNSALQVVKCIERLTDAADSIVDVVLRGVELHPVFEQALEEADERISRVKVSKKSPLADRTLGKLDLWSRIGAYVLVIKRGKDYKFNPTKGVTVRAGDFLIIRGSTLGVEELERVAAGKTKLPLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCD5</accession>
    <name>A0A133VCD5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_03370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000049">
        <property type="protein sequence ID" value="KXB04122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04122">
        <property type="protein sequence ID" value="KXB04122"/>
        <property type="gene ID" value="AKJ48_03370"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.610"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="466" mass="49372" checksum="51599790F8868F7F" modified="2016-07-06" version="1" fragment="single">GDGTTTAVVFAGELLNEAEDLLDQSIHSTVIASGFRMAANKAQEYLEEIALDVNFDDDETLEKVAMTAMTGKKAESARLELAKLAVKADKQITGRTDGGYVVDTDYIGIEKKQGGSADDTTLVNGLIIDKERTHPGMPRRVKDGKIALLNTSLEVKKTETDAEIRVTDPEQLRAFLDEEESMLRKAVDKIVETGANIVLCQKGIDDIAQHFLAKKDILAVRRVKKSDMEKLARATGGEVITSVEDLTSDNLGKAGLVEERKISGDEMIFVEDCEDPKAVSVLIRGGTEHVIDEVERSMHDALRVVAAAIEDGKIVAGGGAPEIELAKNLRDFAESVGGREALAVRAFADAVEVAPRTLAENAGLDSIDVLVDLRAKHDDAKGATLGLNIYEGKVEDMQKGGVVEPLRVKTQAIKSGSEAAIMILRIDDVIAAAEKEMPSPGAGAPGAPGGMPPGAGAPGGMPPGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCJ9</accession>
    <name>A0A133VCJ9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000047">
        <property type="protein sequence ID" value="KXB04176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04176">
        <property type="protein sequence ID" value="KXB04176"/>
        <property type="gene ID" value="AKJ48_03280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="98" mass="11217" checksum="5B10E7FE9C52B5BA" modified="2016-07-06" version="1">MIRSHLPKDLSTLDWYKSMVKMVVASANFGTNGRVVIPKKIRKALKIKEGDTLLFEKVSDRKVTVKIVRGEDEFVKSIHNPGEGKAIKPRRLKKELWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCX0</accession>
    <name>A0A133VCX0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04299">
        <property type="protein sequence ID" value="KXB04299"/>
        <property type="gene ID" value="AKJ48_03100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_protein_L14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="PTHR11127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="93" mass="10472" checksum="61EF2409433DDA4A" modified="2016-07-06" version="1">MVMEIGRLCIKKKGREKGRKCTVVDIIDDTYVLIDGPEVKRRRCNMSHLEPLNQKLDIQKDASSKDINQALTGSISEEPEKNFRGRGGKINGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCX3</accession>
    <name>A0A133VCX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000044">
        <property type="protein sequence ID" value="KXB04280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04280">
        <property type="protein sequence ID" value="KXB04280"/>
        <property type="gene ID" value="AKJ48_03205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="77" mass="8439" checksum="D556D11E5E5908DB" modified="2016-07-06" version="1" fragment="single">MFYVVLVTVGEDSRAREIGRKLVEEKLAACANVISGVNSTYRWKGKVEEIQDVAAMVKSKNIAIFPFAHLSGKLASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCY4</accession>
    <name>A0A133VCY4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000040">
        <property type="protein sequence ID" value="KXB04313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04313">
        <property type="protein sequence ID" value="KXB04313"/>
        <property type="gene ID" value="AKJ48_02990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="263" mass="30503" checksum="9090F017BAC8AC0A" modified="2016-07-06" version="1">MEWSLVCPVKDEIHLLERALPSFYAVNPTEVILCLDKPAPKNVINAIRKTVKACNAEHKTRIIEVEQNPDYEFHQAWVRRKGFLEAKYDRILTTDIDLILNENVLKAIRLVGKNNIGLVSCSKRYSYEGFQRIWRNTGMELVRLIGSPRFTGLYAIWRPHWIDSEDEGIKKLKDPKHGAYREAKVGEDTYLRNCMMRKHKVIYLEDVGGKALATNIWDLPQIQFENGRHLASKEYGILRVLLAVLLQLHAYALLGWLYEVTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCZ2</accession>
    <name>A0A133VCZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04300">
        <property type="protein sequence ID" value="KXB04300"/>
        <property type="gene ID" value="AKJ48_03060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="178" mass="20531" checksum="1FA6616635B05DB5" modified="2016-07-06" version="1">MIDSIKRRRSVRRFEDREVEEEKINEILEAAMFSPSAHAKYPWEIIVVTDKGKRDALSKTTVWSSFASEAPVCFVVLGDEEESERWIEDGSIVSEHIWLESVNQGLGGCWIQVRGGTTDDPEKDPEEYVRRILEIPEKWRVLSILAVGYPATEKSPHKKSNLEYEKIHSEKYGNTYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD04</accession>
    <name>A0A133VD04_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000038">
        <property type="protein sequence ID" value="KXB04339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04339">
        <property type="protein sequence ID" value="KXB04339"/>
        <property type="gene ID" value="AKJ48_02925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="427" mass="49161" checksum="C1F8D63D46920AC6" modified="2016-07-06" version="1">MSKGITFGVLVLFTLSITLTTIPKARSHDSSQITVTGHWIYVELNQSGEAYNVTEIIKVRNDSENRFDGSLKIPIQKGIENFHGDVERDYRICLSVSWENWKAIINPFRGEGVTHDFEEADVPLSYIGQVENLGFIVEVDNVKERIKYTVVAGGENVLKWENVQMGAIKLRYPRRVGTKQMTMGRSGTPTHIYFRENMFLLNLKNNRKQIKFEIENAPMKGWGHDIYRGENVEREFELQAHENMEVTLIGWSPNYEANLRLTYSLDQEPTGKTQIKKKLGYPHGNLQFWILREENRPVIKTSDDLELLGTREAKYKNGAWQVYRVEDPKEGGEYTLTLVFGKGGGVGDWLLVLMAITVASSVFGIYKLLIEKEEKVGEEEPKLSRKAEMMVEALADLRKDHENNEISERAFKELEKRYKEKARDFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD05</accession>
    <name>A0A133VD05_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000038">
        <property type="protein sequence ID" value="KXB04338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04338">
        <property type="protein sequence ID" value="KXB04338"/>
        <property type="gene ID" value="AKJ48_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="257" mass="29256" checksum="A21A1CA1570CD9BD" modified="2016-07-06" version="1">MRVKANKISKIAIVPIVSILVLLSISSVVTAQHQQKDFSVKWRRIEVYQIENDGLRITENFSIQSQKENAEIIILMVDQNFENFSVEENLEENRADFYIKLRLENSLEENREMVMHARYYLPDLPFYRPIYYDCENVIVYAKNFDNSEIENSVPLGHPFSARFGDNISIIEAGEGGIQPPPSGGINLTVLAIAAGLIALLAATYVNRGRIREWMAPEEKVSARDAVLERLESDFRGGKIPEEAYRDILSDLEEESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD13</accession>
    <name>A0A133VD13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000041">
        <property type="protein sequence ID" value="KXB04307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04307">
        <property type="protein sequence ID" value="KXB04307"/>
        <property type="gene ID" value="AKJ48_03050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="105" mass="12610" checksum="768331C81CC36613" modified="2016-07-06" version="1">MKSVGGTPRFYPKEGITLRRRGSWAWTEMLFDLMVDPQRWLREYHVRSNVESGFSIFTRDFLAPLRKRIHRRRKTEAFARTCDYNLKQACYARHQEGLIAPWMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD27</accession>
    <name>A0A133VD27_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04325">
        <property type="protein sequence ID" value="KXB04325"/>
        <property type="gene ID" value="AKJ48_02945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="328" mass="37941" checksum="2E79C25B2AA2AE94" modified="2016-07-06" version="1">MTVFTGLDVHKKSYHATVMDKDGAILRQEDFPNTLEEVKSFFADVKDGEVALEASYFWEPVYDELEEMGFKVKLAHPRKTRIIADEKIKTDVRASEALAHLLRIGWLPEAYVPSKDIRKLRELLRRRVSLVESRTKYKNKVRAELTKRRIRLDGTPWYGPWMDQLETLEIDAIGDYIAIVQSLDDRIDKIEKEIKEKTDESKEVKIIMSITGFSYFSAMTIHASIGEIDRFPGPKQLCSYFGVIPSTEKSGSKVRHGSITKEGDRYVRRVLIQCAWSHVNNCNSYITRLFKRLERKKRSSIAIVAAARKITEAIYWMLKRGEEFRPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD29</accession>
    <name>A0A133VD29_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_02980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04331">
        <property type="protein sequence ID" value="KXB04331"/>
        <property type="gene ID" value="AKJ48_02980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="136" mass="14956" checksum="D2F1D9B25A279F2D" modified="2016-07-06" version="1" fragment="single">MPTVGPQPRFSEAQVHRALEIIGGHSPLGRKKLAEKLGIGEGSVRTILTRLKRENLIASTPRGHIPTEKGKRELKKKARKFLQLDAGNLTVGEVDVATIVRHAYENVKLGIRQRDEAIKAGADGATVLVFSDERFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD32</accession>
    <name>A0A133VD32_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000037">
        <property type="protein sequence ID" value="KXB04352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04352">
        <property type="protein sequence ID" value="KXB04352"/>
        <property type="gene ID" value="AKJ48_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="76" mass="8847" checksum="D221762E542BAB86" modified="2016-07-06" version="1">MLRERRHLVAITAALTASERLRPPKRKTTVWHRPRIEVCARRPNLKVGEVIKKIEVELSGEFIIEVYSTSALREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD39</accession>
    <name>A0A133VD39_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04363">
        <property type="protein sequence ID" value="KXB04363"/>
        <property type="gene ID" value="AKJ48_02835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="140"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="336" mass="38328" checksum="0D7C8D2C12EEF540" modified="2016-07-06" version="1">MPSEIDGGQTTLQRFGASDGEAERSANPPTDSGGPSKLEEEYLEDCEARLTDHTVESHRTALRQFRKYLGGKPPERASKLDVRKFLNELKRKGRARSTISHRLGALRSFFGYIEEYHNIDTPDLYRIRVEDYPESKMEGEGCIALTKTEIRKLIEAASSLRDTLIVCFLYYLGLRAKEVATLKVDKVDPENRVVEVVGKGDKIRKVPLPAVLGRPVRRWLRKERRTYTRSGESPYFFPSKHGEHLRPKSVRKVVDRLAEKAGIQEIIGERADGGKIHRVHPHALRRSFATHGNDEGIPLEDIKRMMGHEKIETTLTYTKESIEKAFESYHTNFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD78</accession>
    <name>A0A133VD78_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_02710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000033">
        <property type="protein sequence ID" value="KXB04408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04408">
        <property type="protein sequence ID" value="KXB04408"/>
        <property type="gene ID" value="AKJ48_02710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="12"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="218" mass="24846" checksum="6400041744B279DF" modified="2016-07-06" version="1" fragment="single">MVCEENKRKYTSFYATGVYGGIGTGYTCGCCLRCVFCWVDWSRDYPEKLGDFYSPKEAFERLSKAAENYGTRKLRISGAEPTLGKKHLLQLLELVEESKFDLFILETNGVPFGVDREYVKEVSKFEKPHVRVSLKAGTPEAFSRKTGAKPEAFEIPFKAIQNLLDYGASFHVAGMMDDPRVVEPEERNELARRLMEINPKLLDSFEGEVIDPYKTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDB6</accession>
    <name>A0A133VDB6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ORF">AKJ48_02570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04446">
        <property type="protein sequence ID" value="KXB04446"/>
        <property type="gene ID" value="AKJ48_02570"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.378"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="305" mass="33668" checksum="3995B7C75EF2E2B8" modified="2016-07-06" version="1">MKLKIIFLGTSGSMPTAERGLTSIIIRREGEVLIFDCGEGSQRQMIRAGFSPMKIDAIFITHYHGDHFLGIAGLVQTLSLMDRERKLEIYGPPGTEEKIGTFLTLPTFTLKFEVQIQDITPGAGIRRKGYEIRTCETQHGVPGIAYALVEDERPGKFYPEKAEELGVKPGPDFSRLQNGEEIEAADGSIVKPDQVMGPPRPGRKIVYSGDTKPIDQMIKFSQGADILIHDATLASDLQELADEGGHSTPIDAAKIAKEAGVERLILTHVSPRYPDSSELEDEAKEVFPDTRVAEDFMELEVELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC6</accession>
    <name>A0A133VDC6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="2">RPPK</shortName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="2">P-Rib-PP synthase</shortName>
            <shortName evidence="2">PRPP synthase</shortName>
            <shortName evidence="2">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prs</name>
        <name evidence="6" type="ORF">AKJ48_02580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04449">
        <property type="protein sequence ID" value="KXB04449"/>
        <property type="gene ID" value="AKJ48_02580"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.380"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_A">
        <property type="entry name" value="RibP_PPkinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037514">
        <property type="entry name" value="Rib-P_diPkinase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="138"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="2">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="292" mass="31772" checksum="01124F00BAD9F3B1" modified="2016-07-06" version="1">MIVGGSASRDLAERISKELDCEFAPVERERFPDGELYVRIPEEIEGEEVAVIQSTCYPPNENYMELFLLLDAAKGLGAEKVSAVIPYFAYARQDARFKPGEAISLKTVAKLIESAGADEVYTIDLHAHRIESTPDVFNIPAQNLTAAPLLAQYASEEFQLEDPVVMGPDGEAKQWAENAGKAIGADWDFMVKERLGPEKVEITPRELDVEGRDVLVIDDIISTGGTMVEAIQILKEHAVKNIYAACTHPVLGTNALEKIKMAGAEEVVGTDTIPSKVSVVSVAPIIAKAFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDF6</accession>
    <name>A0A133VDF6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L32e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_02440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04486">
        <property type="protein sequence ID" value="KXB04486"/>
        <property type="gene ID" value="AKJ48_02440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_L32e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="129" mass="14991" checksum="9BC596929A76847A" modified="2016-07-06" version="1">MSKKKFKRQEQHRFKRLKDSWRRPRGRDSKMRKDKKGKQPRVKIGYRKPRAERGIHPSGFRETLVRTPQDLEKINPETHAARISSTVGAKKRGQIISRAKELGVKILNVKDSELGGRESELEDTEETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDG1</accession>
    <name>A0A133VDG1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl30p</name>
        <name evidence="2" type="synonym">rpl30</name>
        <name evidence="4" type="ORF">AKJ48_02420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04482">
        <property type="protein sequence ID" value="KXB04482"/>
        <property type="gene ID" value="AKJ48_02420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="3">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="155" mass="17549" checksum="B8D3B6913D970E5E" modified="2016-07-06" version="1">MSKLAVIRIRGTVDIRRKVQDTLKILGLTRPNHCVLVNDDPSTRGMLQEAKDFITWGSLNPEVLEALIRKRGRLEGNAPVTDEVIDSKTRFKTIGEFAKAILEDEAELSELKGLKKAFRLRPPKKGYKSTKRPFKDGGSLGFRAEKMNELVKRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDG3</accession>
    <name>A0A133VDG3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps8</name>
        <name evidence="5" type="ORF">AKJ48_02450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04488">
        <property type="protein sequence ID" value="KXB04488"/>
        <property type="gene ID" value="AKJ48_02450"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.352"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_S8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="129" mass="14624" checksum="E773CDDF26719966" modified="2016-07-06" version="1">MTKDPLADALSSIKNYEETRKRKIILDPASNMIGDMLRVMQDEDFISDFEFIDDGKSGKFRIELMGKINDCGVIKPRFSVKHDEFEKWEKRYLPAAGFGALIVSTSNGIMTHKEAQNQGIGGRLIAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDI1</accession>
    <name>A0A133VDI1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000027">
        <property type="protein sequence ID" value="KXB04503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04503">
        <property type="protein sequence ID" value="KXB04503"/>
        <property type="gene ID" value="AKJ48_02375"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.338"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="PTHR38149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="575" mass="64787" checksum="41E26F3723FDCBD0" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDI3</accession>
    <name>A0A133VDI3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_02360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000027">
        <property type="protein sequence ID" value="KXB04500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04500">
        <property type="protein sequence ID" value="KXB04500"/>
        <property type="gene ID" value="AKJ48_02360"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.335"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="350"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="412" mass="44926" checksum="C2502C8CC3216826" modified="2016-07-06" version="1">MKRIVVKFGGTSIGDGELLRKAAESVCDEFENGTQIIVVVSAMGSTTDVLLEGAKQSTEGELDPKELDEILSMGERISARTFASTLCSLGMKAKPILPEHEKWPVITDSEFGNATPDLDKTRELTKKFILPLLEDGIVPVICGFLGKDPKGNITTLGRGGSDITAFLIGNCIDATDVIIVTDAEGVMSADPRRIDNPEILDEVTADEICDLARYGARILHHHALRYKNPDINARIIHFRHANLSAKGSMIVGALKGGERTSTELYPKPLAMLTVVGEGMQTVPGILVKAIKPLSDSDINIFGVSIGPRSFSLYTTEKESQKALEVLHDSVKKDEIMKSATSKSGVGMIVTESEKFIDTPGIIAKLSEPLAENDINVLEIYSSQASISFFVNWEDREKAFELLKKEMEEMEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDI7</accession>
    <name>A0A133VDI7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fumerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_02325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04513">
        <property type="protein sequence ID" value="KXB04513"/>
        <property type="gene ID" value="AKJ48_02325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.328"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="290" mass="31534" checksum="520D18559A239526" modified="2016-07-06" version="1">MIAKENFLDNIEEMLKLAATRLPSDVVKALEECKKSEDNPIAIQQFESILENLEIAEREERPICQDTGIPIFFVKLGSEIDLDFDLNSVLKEAVRNATESVPLRPNVVDPLTRENPGDNTGENQPIIHLEIMPGEDLEIDLMLKGAGSENWSKLFTLKPTSTSEDVKEIILKTIEEAGGQPCPPTIVGVGIGGSADAASLLAKRALLRPLDEENEDEALAKLEKKITENANKLGVGPMGLGGKNTVLGVKIAKAGCHTASLPLAVNLQCWAARRSQARLVDDELEIEVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDJ1</accession>
    <name>A0A133VDJ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">50S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04491">
        <property type="protein sequence ID" value="KXB04491"/>
        <property type="gene ID" value="AKJ48_02460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="5">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="6">
        <location>
            <begin position="50"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="159" mass="17330" checksum="DFE468C8A0BF3FC5" modified="2016-07-06" version="1" fragment="single">GKITINMGVGVGGKKLSNAEAVLEEIANQKPVRTYAKKTNKDFGISKGSPIGCKVTVRGRKAIPILEKLFKAIGGEISGNSFDGNGNFAFGIKEHIGIPGLEYDPEIGIYGMDVCVSLIRPGFRVKNRRRESRPIPKSHQINSEEAISFLEENFDVKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDK3</accession>
    <name>A0A133VDK3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl6</name>
        <name evidence="5" type="ORF">AKJ48_02445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04487">
        <property type="protein sequence ID" value="KXB04487"/>
        <property type="gene ID" value="AKJ48_02445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.351"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_A">
        <property type="entry name" value="Ribosomal_L6_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_L6_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_L6P_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="96"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="177" mass="19992" checksum="A8CAE620917E232A" modified="2016-07-06" version="1">MPITKIREEIQIPEEVQVEVQGANIKVSGPKGEVSRTLDLRGISFRKEDDVIIIESNSTRRKRRATLGTSKSHLENMIRAVTDGFTYKLKVVYSHFPISVNVQDDRVEIHNFIGEQKPRVAKILGDTKVEVKGDELIVKGIDKEDVGQTAANIEQVSQVRGRDPRVFQDGVYIIERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDK5</accession>
    <name>A0A133VDK5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ORF">AKJ48_02430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04484">
        <property type="protein sequence ID" value="KXB04484"/>
        <property type="gene ID" value="AKJ48_02430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="PTHR23410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="199" mass="22531" checksum="22288E951B2BD85B" modified="2016-07-06" version="1">MPRKKYGPHEVIEYRRKREGRTDYQRRIKLLRSGKPRLVVRPSLKHVRVQVIQAELDGDQTLASAFSKELSNFGWKGQTSNTPSAYLVGLLGGFRAKKTGVEECILDIDRHVPVPEAKIFAALKGTLDAGVTISHEEDVIPSEERIQGRHIAQYAESLKSDDEAYQNQFSKYLENDLAPEDLPEHFNQVKQAIITKYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDL7</accession>
    <name>A0A133VDL7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ48_02240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000024">
        <property type="protein sequence ID" value="KXB04543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04543">
        <property type="protein sequence ID" value="KXB04543"/>
        <property type="gene ID" value="AKJ48_02240"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.309"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="773"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="10">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB04543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="834" mass="89149" checksum="9434B83F565D3195" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDM2</accession>
    <name>A0A133VDM2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000024">
        <property type="protein sequence ID" value="KXB04540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04540">
        <property type="protein sequence ID" value="KXB04540"/>
        <property type="gene ID" value="AKJ48_02215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="222" mass="24255" checksum="5356404749ED5EE0" modified="2016-07-06" version="1">MVYSLELKTVREWGNGGNMGRKWLMLVVAFFSVFSFLFAMQSLPPVIPQIMEEFNVSHAETSLLMSLVALPVIFLSLPAGILTVKWGPKRVSGLGLILATFGALTTYLANSFLWLEIGRLILGIGGALVAVSAISIIPQWFSREELGKAMGIYAINMPIVTITALNLLPRIASGFGWRTSFLIATIILAAAALANISLIRGNHRRRNQSQCMLASRISKYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDN9</accession>
    <name>A0A133VDN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_02205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04559">
        <property type="protein sequence ID" value="KXB04559"/>
        <property type="gene ID" value="AKJ48_02205"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.302"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="309" mass="34148" checksum="99999C4EC89298AD" modified="2016-07-06" version="1">MSALIQADELYKGFSDVQAVDGVSFEVEEGEVFGFLGPNGAGKTTTVRMITGVLEPDSGTAWVNGKNVREEPTEAKEEIGIAPEVSNAYIDMTGWQNMMLMGELYGVSKDRREKRGKELLELFSISDRKDSNVKGYSKGMQQRLVLAMALIHDPPILFLDEPTAGLDVQSQRLIKTRIREMNEEGKTIFLTTHNIPVANELCDRVAVINHGKIAAIDTPEKLKGAIEETRSVEVGFENGLEISELKELEKAEKIEKRGDKYRIYTSNPIGTVELLLGLAKEKNEKILSIRTLGPSLEDAFVELTGGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDR5</accession>
    <name>A0A133VDR5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type ATP synthase subunit C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpC</name>
        <name evidence="6" type="ORF">AKJ48_02095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04571">
        <property type="protein sequence ID" value="KXB04571"/>
        <property type="gene ID" value="AKJ48_02095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00314">
        <property type="entry name" value="ATP_synth_C_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014272">
        <property type="entry name" value="ATPase_V0-cplx_c_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02923">
        <property type="entry name" value="AhaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="2 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="383" mass="44130" checksum="891854DB76EF99B3" modified="2016-07-06" version="1">MNEILILLIVLGIIGGISAFIVIRTRRIMPYVYCGARVSAWEAKLFSDTRLDELSESPNTERVLGALEDTDYRPYISDISREEGVDVEEVERALNYCLNDTYQELIEMTPEERRDIVEKIVERINVRNLQAILTGVEKEIPKEDRMKVLTPSPTLPEDKLEMLASAENLDRILEYLEESEYYDTLSETMEEGYAEWGVSALIWALDGFYYSNLWENIRTKKAQRSILEKMIGIELDAINIKLILRLKKEDVHPGTIAEFTVPSHLLSNEQIERMMTAEDVQSAAEVTSDTPYGPVVQGALQQFEETGSLFALEKALDEEILKMSREISLIQPFTIAPVINYLRLKETEVRNLRTIIRLKAEEVKPEDIRNALVRKWEIELRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDT7</accession>
    <name>A0A133VDT7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="11">ASA dehydrogenase</shortName>
            <shortName evidence="11">ASADH</shortName>
            <ecNumber evidence="7 11">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">asd</name>
        <name evidence="13" type="ORF">AKJ48_01985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 11"/>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04609">
        <property type="protein sequence ID" value="KXB04609"/>
        <property type="gene ID" value="AKJ48_01985"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.225"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="12">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB04609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="355" mass="38727" checksum="6F5AB49DD85D77A2" modified="2016-07-06" version="1">MAKTPVAVLGATGMVGQRFVQLLVDHPWFELKALTASKRSAGKRYEEAAKWFLRPPMPEEIKDTEVLPTSEKSVEGADIVFSALPTSTAKDVEPKMAEAGHLVASNASSYRMEPDVPLLIPEVNPDHLALLDEQKDRRDWDGAIVTNPNCTTIILVLALKPLFDDFGIKRAFVSTMQALSGAGYGGVKSMEIQDNLIPYIGKEEWKTENETLKILGKLEDNKVSPAKIKVSSSCHRVPVLDGHTEAVFLELEKKANPKQASKSLSDFVARPQELGMPTAPEQPIIVDERNDRPQPRSARFAGSIPGMAIVVGRIRKDPVLKNGLKFIVSGNNVIRGAAGASVLNAELIKSEGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDU2</accession>
    <name>A0A133VDU2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04610">
        <property type="protein sequence ID" value="KXB04610"/>
        <property type="gene ID" value="AKJ48_01995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="358" mass="39090" checksum="B815D709358A9C4B" modified="2016-07-06" version="1">MSPENGVWEDNFTFKVTYMENENDLPSAGYPKVYIDNQPVNMIENDSTDNDVTNGKLYKYVWVTSKPDAGNHNFYFYAEDNQGENARAPENGAYGGPNVGKKSVLLLYEVSDPRPDPGENVVFSGYLKTADENLGVVGENVVLYEVLSENTVEVKSVITGENGYYAISLNVSSKRVGSYFIKFTANDYYKETGTPRLYVNSLDKPFILGVAIISILVVMLVLFFLLSRGVAKEQFAKPLLIALAVGVLLQFIGAGFIALAVAGGIAGYLFSKRTGKWTEHLRIGIMTGVLLALVYGIVFSLVLAESPELLGLEYSITQGEIFSIISAQTIYFLAFYNLLTGIGAMLGGIIGGPSKSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDW6</accession>
    <name>A0A133VDW6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fen</name>
        <name evidence="15" type="ORF">AKJ48_01855</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04642">
        <property type="protein sequence ID" value="KXB04642"/>
        <property type="gene ID" value="AKJ48_01855"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.201"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_structure-sp_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 11 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPGN" evidence="14">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="53EXOc" evidence="12">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="13">
        <location>
            <begin position="140"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXB04642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="341" mass="38398" checksum="806C69693F6826BC" modified="2016-07-06" version="1">MGVQIKDIVPIQESSLEQLQGKIIAIDAMNTLYQFLSIIRQSDGTPLKDSKGRITSHLSGLFYRTSNLIEKGIRPVFIFDGEPPELKSKTIETRRTLRAEAEKARKKALKEGKEKEALKYAQRSARLTEEMSGESKTLLDAMGVPWIQAPEEGEAQAARLTQNEDSWAAGSQDFDSLLFGAPRLLRNLTITGKRKLPGKDVYKEIVPEVISLEKLSEEQEITREQLIAIGILVGTDYNPGIKGIGPKRALKLVQEHGTISDILEAEEDLEFEVDPIEIEEIFLEPNVTDDYEVSWSEPNPDAIKEFLCEEHDFSESRINTSIERLEKGASKRSQESLEKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDX0</accession>
    <name>A0A133VDX0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">sat</name>
        <name evidence="10" type="ORF">AKJ48_02050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000021">
        <property type="protein sequence ID" value="KXB04594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04594">
        <property type="protein sequence ID" value="KXB04594"/>
        <property type="gene ID" value="AKJ48_02050"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.268"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase" evidence="8">
        <location>
            <begin position="162"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="383" mass="44238" checksum="BA6F7F8106CACAD5" modified="2016-07-06" version="1">MKLVNRILENQERKKVLDEIDEYPSVSIADEMILDAELIANGGYSPIDGFLTQNDLQLVLDKMHLSDGSPWTIPIVLPVNEDAINEISEEDDVVLKSSEDEKIAILHLEEIYGFDKKEFASKVFGTTDSDHPGVGWTFYDWGDTLLAGKVDLLTRPKHPFEKYHMDPEETRKEFQKRRWETIVGFQTRNPVHRSHEYIQKCALEIVDGLLLHPITITRKGDVPAKTRMKTYQLMLNKYYPRNRVILSTLTTAMRYAGPREAVFHALIRRNFGCTHFIVGRDHAGVGDYYGPYDAQRIFNEFNEGELEITPLFFENAFYCRKCDSMATEKTCPHLKSNRVAPSGTKVRRILLEDENLSKKIMRPEVAELLREYYQKINDKGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDX2</accession>
    <name>A0A133VDX2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_01880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04646">
        <property type="protein sequence ID" value="KXB04646"/>
        <property type="gene ID" value="AKJ48_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="346" mass="38128" checksum="E0AA0235BDB26F37" modified="2016-07-06" version="1">MTKESQEVSVNLRRTLIPIFIVTAIIIIAVVLLLQENIGGIVTALQNANYLFILLAFIIYFSSAFFWAARWRIGLFALGKNASMRNLFPIIWGSMFINNMTPLNRAGGDPIGRPYLLKKTSGIRFRMGFASVVAEQLFQIPVVLFLLAMGLILRVQMTANPGLVSIATVVISLSLAIVLVPFFILLFGKKEFSSKITGFLTKILKFFRREADPTKILKTVEDFRVSARKIINSKHNAAWMMGFSAALWILDLVRISLILYALGINISLPMLFLASTLPQIAGLVPLLPGGIGAVEVTMVSVFMWFGVSPVLALSATLIERSMSFVFSTLIGAGALSYLGIKIWTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDX3</accession>
    <name>A0A133VDX3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04625">
        <property type="protein sequence ID" value="KXB04625"/>
        <property type="gene ID" value="AKJ48_01940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="91" mass="10819" checksum="BD4035153F43B15D" modified="2016-07-06" version="1">MLDGKIDPLSYYGENARTEALAMSSEERIELLKTLVPTSQTEFSSRDVEEMMEISFRRSKELLKKWFEKGLIYRRWKQNGNVGQFLYRFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDX5</accession>
    <name>A0A133VDX5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04607">
        <property type="protein sequence ID" value="KXB04607"/>
        <property type="gene ID" value="AKJ48_01975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="280" mass="32118" checksum="E64757AB228E5B26" modified="2016-07-06" version="1">MDERMQIGVSTAIFWDYKKLDLPSAIFHSVEGLGFEAVEIHCEDPLFEGWSTEKAEATKKEIKDTLSTLDVGVSLHAPYHDLNIATLNARVEEEVIRQHKDCIETARFFGSEIVNVHPGFRSSRKFKREVVFQKMLQNFAEICEIAEDYGIIICVENLASKRKAMGVKISELKSIIKRVNDENLKLTLDVAHANTTDEEPRVYARELKDYIQHMHLSDNTGNDDHLSLGQGNIDFKEVLKKLQPYDGFLIVEGWIPEDEDPFLELDRTKLEEIREELAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE01</accession>
    <name>A0A133VE01_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04624">
        <property type="protein sequence ID" value="KXB04624"/>
        <property type="gene ID" value="AKJ48_01935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="240" mass="27960" checksum="B62AC02521E3E6DC" modified="2016-07-06" version="1">MHGGEVEFSFQDRKQNILIPDSVTKEVAYETGVHIGDGWMNIIREGQYRTPHHRVSYTGNLIDELKFHKEILIPLIHRIYNKHAYLMKRPGNVCETAFKSKAIVSFKSKVLRLPKGPKRTLKGIPHAIVDESDKCVRECVRGIADTDFSLAFLRKHRGVHYYPKIRYSSPSKNLVKDIEYWLGDIFDFDVASCYDIHRKDPRIKGILTTHTLELNGRAMLEKWMDEIGFRNEKHLSKFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE13</accession>
    <name>A0A133VE13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_01815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04671">
        <property type="protein sequence ID" value="KXB04671"/>
        <property type="gene ID" value="AKJ48_01815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="278" mass="29616" checksum="4B12D7D7FA498B13" modified="2016-07-06" version="1">MSEFEKLKIVTRYELLKQFRRKRFMGALIIVILAQILVIGLYHGLDIPGSLSDPASGIIISDTPELFAIFVTSMSSIAVIAAVFFAGDAIASEFEHKTGYILFPNPVKRTTLVTGKYLACFIATALILIVAFIISAIALVVFYGQIPIGILGSLAIVLMLAGCIISMAFAFSSALKGGMGATIATLLTFMVLSSVISSSLAYAGYNPWFMPDRAADAMAATYSVSLEELAGGMYGGGGVMGGMAQASQDPTLSFLVLATYAIILFGVSVWLTKRRQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE16</accession>
    <name>A0A133VE16_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04647">
        <property type="protein sequence ID" value="KXB04647"/>
        <property type="gene ID" value="AKJ48_01885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.208"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="310" mass="34337" checksum="A12E69DA59271720" modified="2016-07-06" version="1">MKILITGGAGFIGSHLTDKLLTNNHEVIVLDNLFTGKPENLAQHENNEKFTFVNADITNRKKVRESLKEARGVIHEAAITNVPLSIKKPELTEKVNVKGTKTLLEESANADVERFVYASSCAVYGEVKDLPISEDFELNPISPYGESKLAAEELCQKFNKDQGLDTVCLRYFNVHGPRQTFGPYAGVILKFLKRAKKGKPPIIFGDGKQTRDFVYVQDIVRGTLLALRQKDVGGQIFNIGSGTAISINKLCETILNVTNSTELEPIYKEAKPGDIRHSHADLSKAKEILGFEPKVSLNEGLARLVKKFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE41</accession>
    <name>A0A133VE41_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04716">
        <property type="protein sequence ID" value="KXB04716"/>
        <property type="gene ID" value="AKJ48_01660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="138" mass="15918" checksum="C066C0AC25F32F30" modified="2016-07-06" version="1">MTEDLEIKIKYGDLQAEVKGEYSSVWKYTNEFFKKVRKEFKPEGESTFSVEGKTLPEVITDLRDNGFFDKPRNSRATHRRVKELGKTGHTKSAVAMQLKNLSGKGELVRKSMEFFGLDGQGYAYVSPWYDLDQHRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE59</accession>
    <name>A0A133VE59_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04736">
        <property type="protein sequence ID" value="KXB04736"/>
        <property type="gene ID" value="AKJ48_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="165"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="465" mass="54078" checksum="3C473BB0B6F4DB27" modified="2016-07-06" version="1">MRKGNDWLKFLSKHKGEGLSLEELSSKYQREKKQRNTNCNEDEQKKFSKSDLKEYEEVKTWLRTVSKTTKGNYLSALKKFCNWCDKDPHQLIIERDKEKNIDDPNKRNRTKNLILDFRKHLEDEGYAPSSINTMDGAIRGFYSSVLGREGMINVGNYEHRDVTLKKDLVPTLEELRKMLDVSDISTKFDIIFLAQTGMRPEDALNLKVGDIQRELDLNRSPLAIRFLPKKDRNKGIGERITFLGADGVKILKQYLEWRKNKGEEVTSDSPLFIGRIGQYDGKKVGSLSKQKLNDRIKQAAKKAGIENGDNGKYGHVRTYCLRKFFMTQLTNHGMEDRIVDFLMCHKVSPVDLSYWQRRVDQLREEYRKREKFLNPISGAPSKPSADEIEELVENKLTEFIHSEEFKEACLEILREVPYLNSNDSYKSIIVKSEEKIIKLSNKGYDCQPLENGKWLMRKEINEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE67</accession>
    <name>A0A133VE67_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ORF">AKJ48_01740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04694">
        <property type="protein sequence ID" value="KXB04694"/>
        <property type="gene ID" value="AKJ48_01740"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.176"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="137" mass="15585" checksum="071F9A57B19838F8" modified="2016-07-06" version="1">MTERTFVMIKPDGVKKGLTDEIASRIRESNLKIIEMKQMELDRETAEELYSVHEGKEFFEKLVKHVTAGPVIPMLVEGDNAIKRMREIIGATNPEEAEEGTIRADFGSDITNNIIHSADSPESFKREARIFFSEDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE80</accession>
    <name>A0A133VE80_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04707">
        <property type="protein sequence ID" value="KXB04707"/>
        <property type="gene ID" value="AKJ48_01615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.151"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013670">
        <property type="entry name" value="EcoEI_R_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08463">
        <property type="entry name" value="EcoEI_R_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="52"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="616" mass="71454" checksum="83A5C42712261067" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE95</accession>
    <name>A0A133VE95_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04766">
        <property type="protein sequence ID" value="KXB04766"/>
        <property type="gene ID" value="AKJ48_01540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="199" mass="21291" checksum="C1A5F37D608668C2" modified="2016-07-06" version="1">MNDSPRKIATLTIACALLILTTSNLANAAEEDYIGGLSISMLNPPDSVATGETFTVKVRVANNSGSTVSACLCPPPAEGFEWVPINEGGWVPNERYVTINSGETKTYEFTLTVREDVQFASGSTAQARLRARIRELEANVVVAPDDTKEVVIRHETETWSIELPLILKIIIAFAGIAAVIGAVKMSGGEEVPVEPSPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEA6</accession>
    <name>A0A133VEA6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OrfB_Zn_ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04780">
        <property type="protein sequence ID" value="KXB04780"/>
        <property type="gene ID" value="AKJ48_01430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="5">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="421" mass="47983" checksum="038DBE8E7312852C" modified="2016-07-06" version="1">MVEEVRTVKLNLLNLTERKSKLLSELLNVCKSAGDHLFKTAVYLEVFNKPESRFALQEVEYDHIKERFALHSQIIVGLCKDVFTAYRNGGLNFFKYTIPYNVPRSSKLAETENGNPVISVATLDGRIGLPISQDGAWERFNEFLEDGYEFTSFRLKKEQDDWHILVPLRRESEVKGEFDSVLGVDVGSRTLASVTVLSKERVEEQLYFGRDVWEKQRDISIRRSELQSHADRGSSKARRKLRDLKNYESNFVKTRCYQVAHKIVKLAKQYNSVVAIEDLTGLKNARGHRKSDRRTKRMPYCTFRVALESVCKREGVPLIAVDPYHTSQSCPNCGSLGKRKQKGVIFECECGYRANADRVASLNIALRASETIHNSKRIFAQSPKGNVPVNGHDWRDWGSEIMSSHGYSPPERKPTTSIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEA8</accession>
    <name>A0A133VEA8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04765">
        <property type="protein sequence ID" value="KXB04765"/>
        <property type="gene ID" value="AKJ48_01535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="162" mass="18825" checksum="BEE3EE7FB6886860" modified="2016-07-06" version="1">MKFIVDSMLGKLARWLRLAGQDVIYANDFPPTAESQDESLLLRAKEDYRILLTRDLELHRQAISRRLKSIYLEDDDVVNQLVEVSNHCEEDVRIDLTDSRCPVCNGELNQVGKEEVSGRVPENLLEEHEDFWICMDCGKIYWPGTHWETIAKIAEEYEEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VED0</accession>
    <name>A0A133VED0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AKJ48_01530</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04764">
        <property type="protein sequence ID" value="KXB04764"/>
        <property type="gene ID" value="AKJ48_01530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.133"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00645">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023472">
        <property type="entry name" value="Uncharacterised_MJ0810"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="201" mass="22474" checksum="3D5A59D4771D3F5C" modified="2016-07-06" version="1">MLTLEEGKFLVGLARQSIETYLDESKKPETPEVPEKLRESRGVFVTLRKNGELRGCIGRPLPTQSLVDGIIDSSINSAVGDPRFPSLEKEELKNVNIEVSVLTPPEVIEVKTPRDYPEKVKVGKDGLIVERLGSKGLLLPQVPIEQGWDVEEFLTHTCLKAHLKPDCWLKNDVKIKKFSAQIFAEKEPGGEVEERSISEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VED2</accession>
    <name>A0A133VED2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04808">
        <property type="protein sequence ID" value="KXB04808"/>
        <property type="gene ID" value="AKJ48_01375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1250">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038087">
        <property type="entry name" value="RNAP_delta_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HTH HARE-type" evidence="2">
        <location>
            <begin position="89"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="301" mass="34079" checksum="012C12AF43DA03ED" modified="2016-07-06" version="1">MGKSTFIEAAYKVLKKENQPLSAEEITSIAIKDDLISTKGKTPSATMSAQIYMGIKRKGKDSRFRKVGPGIFGLREWEQPSKTPAFRKGSFKRAAYETLKQAGKPMSAEDITKISLNRGLLETSGKTPDATMGAQLYMDIKKKEDESFFVQLGKNRFGLREWGLEALEEDIEKVEKEKVPTAADKKRSIVGDPINLKGLVYGPINENGVIFLFAKVHEELGINIEAIQPAFPDAKGRRRKGKGWEDVWIEFEYKSSDFKRHDHNPKECDIIVCWNHDWEDCPLEVIELKSVIQNLKTRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VED3</accession>
    <name>A0A133VED3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04812">
        <property type="protein sequence ID" value="KXB04812"/>
        <property type="gene ID" value="AKJ48_01405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.103"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="186" mass="20767" checksum="5C075C23B09DC189" modified="2016-07-06" version="1">MPRAFVSIEIADDIRNQLVQVQEKLGETGADLKLVEPQNIHLTLRFLGDVPEERLSKIKNAIRDAKDIADPFNLHVSGLGVFPNPNYMRVVWAGVSDGSNPTTALRQKLDKNLAKINLPSDNKEFTPHLTIARVKSGKAKEKLREKLTRMSAKDFGTCRVDAIELKESKLTSEGPIYSTLEKFELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEG8</accession>
    <name>A0A133VEG8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04850">
        <property type="protein sequence ID" value="KXB04850"/>
        <property type="gene ID" value="AKJ48_01210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="98" mass="10750" checksum="D696F813EAA6406B" modified="2016-07-06" version="1">MAKVKVLKSFEYGGKKRMKDEEVKLPASVAKEVVDRGYGEPVEEIPTFGEPEELGEFEKSSEASKETSTSGKGINVDRYAKSGGWSLQTMSARETGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEH6</accession>
    <name>A0A133VEH6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04852">
        <property type="protein sequence ID" value="KXB04852"/>
        <property type="gene ID" value="AKJ48_01220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="144" mass="16817" checksum="038AB5A0CC0A3253" modified="2016-07-06" version="1">MKTRTVFKDKNKLSPKYIPRKLVDREEEFRELVRLFHHVLEEGGSQRVIVCGSLGSGRTILTNVFAHEMRKFGKKRGIDILPVYADCRKDRTPREVLGRLQRTCDLEKPIRGVSYASILERVVKQMKSRDAYLEAKARNREVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEJ4</accession>
    <name>A0A133VEJ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04873">
        <property type="protein sequence ID" value="KXB04873"/>
        <property type="gene ID" value="AKJ48_01095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="91" mass="10229" checksum="2B1C3FF169870E21" modified="2016-07-06" version="1">MPNVIYDYGKCNGNASCAEVCPVNILEESENGRWCKPIDEKVENEEAVKQFHEEVEESETQLDVTIENDMPECIQCMACVASCPEDAIQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEJ6</accession>
    <name>A0A133VEJ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04869">
        <property type="protein sequence ID" value="KXB04869"/>
        <property type="gene ID" value="AKJ48_01075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="92" mass="10058" checksum="BB2CF9C12D3223B8" modified="2016-07-06" version="1">MGHLLVLRISRIAILILAGMVVYLALRSYHRGDGKVMLYLSAGFSLIALGALTSGLLFELLHLELALTYTIESFMSAIGLAIIVYSIYGVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEN8</accession>
    <name>A0A133VEN8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7 8">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="10" type="ORF">AKJ48_01025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7 8"/>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04908">
        <property type="protein sequence ID" value="KXB04908"/>
        <property type="gene ID" value="AKJ48_01025"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.713"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="337" mass="36561" checksum="82C33579BA8A7174" modified="2016-07-06" version="1">MPCTIIAGGQWGDEGKGKIAAYLALTDKPKIIARAGVGPNAGHTVVWKGEKLGLREISCGFVHEGARVLIGPGVLVNPEVVLDEIEKTEIGDRMGIDRKCAIIEQKHIEQDRSSKHLKGEIGTTGTGCGPANAERVNRSSKLAEEIEELKEFLTDVPQEVNVALEKGERVFIEGSQGFGLSLIHGTFPYVTSKDISASTLAADVGVGPTNVDEVLLIFKAYISRVGAGPFPTEMPLEKAEEMGIVEHGTVTGRRRRIGEFDFDLAKRSIMINGATQLAITNVDRLFDGNKGIQKYDKLTKEARDFIEKIESEVNVPVTLVSTGPKTEDIIDLRSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEP9</accession>
    <name>A0A133VEP9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ub-Mut7C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04918">
        <property type="protein sequence ID" value="KXB04918"/>
        <property type="gene ID" value="AKJ48_00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="93" mass="10281" checksum="5E2359E12FB6EB6C" modified="2016-07-06" version="1">MPIEVRLYGNLKLKASSTKNPAGFPAILKVDAGEVSEVSDVFQALGIGKDEASHVFVNGEYSGLGKDVKDGDRVAIFPKDMSLLYKWYFRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ4</accession>
    <name>A0A133VEQ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04933">
        <property type="protein sequence ID" value="KXB04933"/>
        <property type="gene ID" value="AKJ48_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="81" mass="8860" checksum="C275E677425ED8DA" modified="2016-07-06" version="1" fragment="single">EVEQVGTIEKIEGEPRPEISDDLKDKALLALEKLEGEDGTTPPDLAAELDISASKAEDVIATLINDDKIYEPNPGKFKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VER3</accession>
    <name>A0A133VER3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04926">
        <property type="protein sequence ID" value="KXB04926"/>
        <property type="gene ID" value="AKJ48_00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="138"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="510" mass="57173" checksum="B2B3B0FF885D6522" modified="2016-07-06" version="1">MTGEIGTVICTSDGPSSTQFSFVVTTRKGEIPVRRGQFIELESEEGRIIAQVQDLFKTNRYFMRPESVKEYEKGNRSLNSIFPADRWEYLVARAKASGVQTNSGLEQTTFPVSPGQKVYEANLDELAQFLGTDTNDGVELGKLKFHDLPARLDLTKLLRKHVAILAMSGSGKSYTAAVLVEELLERAREEGRVASIIVDTHGEYTTLAQANDGVDYSDRATVVKGGNVKIGVPNMSAYQFREFSPDMSGSQVRELNRVLKGLRSEMRSGKGRYDLDDVIARVEEDGESKKNTRQALLDRLYDLKSLQIFGKNDYPNWRKLAQPGEVAILDLSGVLNLRKKRVILTYFTRKLFNKRKTGQAPPFALFLEEAHQFAPSKKSVISSSILKTLAREGRKFYASLVLISQRPVRLSTTILSQANTNIILRVTNPYDLDHIKQSSERITRDTADIISSLPVGQALIVGEAVNHPIFVKIRQRKTQEAKHGASLKEVAKKYEKQHDQELEDAKAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VET4</accession>
    <name>A0A133VET4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_00750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04945">
        <property type="protein sequence ID" value="KXB04945"/>
        <property type="gene ID" value="AKJ48_00750"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.515"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="470" mass="52257" checksum="3E0829807A73C152" modified="2016-07-06" version="1" fragment="single">KSKVIATSTKICYGLPDRSDDLVDDIVEDMVENGQDGVLITDLEKVGEVAVRVAQAIYDSRRDIKATPSRGEIGELLDNCVLCGSCDKSCPNDLSIMKSMEEAKEGDFEKLANLYLDHCIGCGRCDEACPNDVHIMKVMEKAAEKKVKKEKYKIRVGRGPIRDTEIRDVGAPIVMGEIPGVIGMVGCSNYPDAPKGFREPLYRLAKEMAERNYIITLTGCHAMDVAFLENEDGETIYEEFSGAFNAGGVVNCGSCVSNAHISGVPIKIANIYARMGLRGNYKEIADYILNRVGAVGVSWGAMSQKAVSIANGFQRLGVPVILGPRSSLYGRSLMGRRDKPKLWKTRNKRKPEEGEYMIAPGPEHLVYYAESPEELLVKSAKLCIRPADTDAGRQIKLTHYIDLYNKYFNGEYPPDLYMFVRREHDVPIKYRTEVMKMLEEDPRWEKGKFGGGQPTILSEKEIEEGLGKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VET8</accession>
    <name>A0A133VET8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydantoinase_A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04956">
        <property type="protein sequence ID" value="KXB04956"/>
        <property type="gene ID" value="AKJ48_00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002756">
        <property type="entry name" value="MfnF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03123">
        <property type="entry name" value="one_C_unchar_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase_A" evidence="1">
        <location>
            <begin position="57"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="342" mass="37863" checksum="5DE7B3A2E75EBE83" modified="2016-07-06" version="1">MLSIGIDIGGANTKALLLKDGSVEKDWLEYIPLWERKEDLESFLDKLAGVKQVQATGITMTGELSDIFKSKREGVKEIIKIASEKLENKACYFMSSNGELLSKDKALDSPEEISAANWIASGLVVGEEYPNCILMDVGSTTTDLIPIQNGTPTSLGRSDFQRLETGELVYTGVLRTPVTYLCPEVEVNGMKVGIASEYFANIGDAYRVLNTLDEEQYNCDTPDGRGKTRDDCMRRMARVFCSDVEELGEEFIEKAAKYFQERQVSLLQKALEKIVDSNKSLRINNIIVTGIGRRILAEEAARSANFKQIIDLADIYGEEAALMTPAFAMSLLAGKTVHNKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEU1</accession>
    <name>A0A133VEU1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Methenyltetrahydromethanopterin cyclohydrolase</fullName>
            <ecNumber evidence="4 10">3.5.4.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Methenyl-H4MPT cyclohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mch</name>
        <name evidence="11" type="ORF">AKJ48_00815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin</text>
            <dbReference type="Rhea" id="RHEA:19053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58018"/>
            <dbReference type="ChEBI" id="CHEBI:58337"/>
            <dbReference type="EC" id="3.5.4.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the MCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.27" evidence="4 10"/>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04952">
        <property type="protein sequence ID" value="KXB04952"/>
        <property type="gene ID" value="AKJ48_00815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.529"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018759">
        <property type="term" value="F:methenyltetrahydromethanopterin cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00545">
        <property type="entry name" value="MCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00486">
        <property type="entry name" value="McH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003209">
        <property type="entry name" value="METHMP_CycHdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02289">
        <property type="entry name" value="MCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03120">
        <property type="entry name" value="one_C_mch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB04952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="311" mass="33551" checksum="5A94A3C30032FABD" modified="2016-07-06" version="1">MISVNESATKIVEKMIENKEALSIEAFTLENGAKVVDAGVDVTGGSRAGKYFTEACLGGLGNLYLTKDKRPRVQVSVDHPAIACMASQYAGWSIKVGDYYGIGSGPARALARVEDLFDDLDYRDDFDSAVLALETREIPGEEVAGYIAEKCGVKASNLYLLISPTASVVGSIQISGRVVETGVHKLHELDFNIGSIITGIGSAPIAPVAGNDLEAMGKTNDCILYGGKTIYFVEGVEDSEIERIIEEVPSSASDDYGAPFLELFEKYDRDFFKIDPNLFSPSEIVINNLDTGRVFQAGRVNEEILKKSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEV5</accession>
    <name>A0A133VEV5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04960">
        <property type="protein sequence ID" value="KXB04960"/>
        <property type="gene ID" value="AKJ48_00860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="90" mass="9935" checksum="08D45DD04E72D260" modified="2016-07-06" version="1" fragment="single">GFGKGTKWDLHILKNLHELKKLNHPVCVGISRKSFIGEVLDLKDPADRLWGSLGATAIAVMNGADMIRTHDPKETIHVVRVVEAIRGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEW8</accession>
    <name>A0A133VEW8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04999">
        <property type="protein sequence ID" value="KXB04999"/>
        <property type="gene ID" value="AKJ48_00710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="350" mass="40689" checksum="F995911F4082008B" modified="2016-07-06" version="1">MKRTTRSIKKLTTKIINSIARVFNPAKNSTYRSLDLAKTLIQICKNESSAERRSKPSPDTILRRLHQTSENQFNQILEELNAELLSKLDLPKRPVIALDYTTKPYYGEEQPTLVSDPNLPGTNLGIRFANLSIVEKGKTYTLKTRQVGPFTSNERIVKEMLEYTERFVEPRIILLDRGFYSVKVIKLLKSRKQDFIMPAKRTGPVKRLCKKFKEGEISPMIDYTIKSSDDSARVKLVFIKRKTEKGVEIHPFISNLELEPREIARLYGWRWRIETNNRELERFSALTTSTSMKIRRLYYSLAALLYNLWIVVRGGSELSRAHQFKRILNSFLWLISAEIKREPRPPPNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX6</accession>
    <name>A0A133VEX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_00705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04998">
        <property type="protein sequence ID" value="KXB04998"/>
        <property type="gene ID" value="AKJ48_00705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.406"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="PTHR19248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="65"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="336"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="587" mass="65722" checksum="1F478F49DB194271" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX7</accession>
    <name>A0A133VEX7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0147 protein AKJ48_00675</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04993">
        <property type="protein sequence ID" value="KXB04993"/>
        <property type="gene ID" value="AKJ48_00675"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.400"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00342">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023130">
        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="86" mass="9664" checksum="267FF61748BBA3E5" modified="2016-07-06" version="1">MSSQEEKLQQVTDIMERVVEDMSVPRNIRRAANEAKDSLRESDDDPVVRAASAISILDEISNDPNMPVHARTTIWNALSVLETVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEY7</accession>
    <name>A0A133VEY7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_00725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05002">
        <property type="protein sequence ID" value="KXB05002"/>
        <property type="gene ID" value="AKJ48_00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029478">
        <property type="entry name" value="TM1586_NiRdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14512">
        <property type="entry name" value="TM1586_NiRdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="TM1586_NiRdase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB05002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="173" mass="19046" checksum="82A2F2F7E193B85D" modified="2016-07-06" version="1">MKVSKAISERRSVRKFKSDPVSEEDLNKILEAARWAPSAGNAQPVELVVLKEKDQKEELVKASLGQAFLAEAPIDIVVCANVPRTKKRYGERGSEMYVYHDTAAAAQNIHLMALALGYGTCWVGAFDDEAVEEVINAPDNIEPHVIIPVGKPAESPNPPRKRSLDEIVHEDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF15</accession>
    <name>A0A133VF15_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05004">
        <property type="protein sequence ID" value="KXB05004"/>
        <property type="gene ID" value="AKJ48_00740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="66" mass="7624" checksum="FBC6E7948E8142D9" modified="2016-07-06" version="1">MEVKVCPRCHSQNVSWSTVFKAEQRTGIFRDKCSNCGYIGTMVIMDKEDADKLEVLDPDDIEEKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF41</accession>
    <name>A0A133VF41_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OrfB_Zn_ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_00375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05068">
        <property type="protein sequence ID" value="KXB05068"/>
        <property type="gene ID" value="AKJ48_00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB05068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="100" mass="10848" checksum="FA82BA73EA6283FE" modified="2016-07-06" version="1">MLRYKCEERGIKYIEVSEANTSRTCSQCGRLGNRRKGLFKCSNCGLEIDADVNGARNIASRALGKSEIRPLVRVGAPVTVPRTLSHEATSGTSTMEAISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF50</accession>
    <name>A0A133VF50_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05078">
        <property type="protein sequence ID" value="KXB05078"/>
        <property type="gene ID" value="AKJ48_00435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018036">
        <property type="entry name" value="DUF429_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024051">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="184" mass="20544" checksum="DA04F6D257E19715" modified="2016-07-06" version="1">MKVIGIDLAGKETNPTGMAVLTEEDLSVSTLGSDDEILSECKDNHPDVVAIDAPLNFPVEGSFREADSELISRGHRVLPPSLGGMKFLTERGIRLAEELREQGFEVIEIHPRTSGKILFETPDREEWIRELEKHGWKLGEDVSEHEVDAALTALTGLLYLKGEFEKVGEKEEEIIIPRESLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF53</accession>
    <name>A0A133VF53_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05060">
        <property type="protein sequence ID" value="KXB05060"/>
        <property type="gene ID" value="AKJ48_00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTS" evidence="2">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="197" mass="22104" checksum="299A72CB2A455821" modified="2016-07-06" version="1">MAYYQDQKFKIHPEVYTPAEDSFLIADNLDVRKDEEVLEIGTGCGLLAILAAQAGAKVLATDVNPKAIECAKENAQDKGVADQIEFKLGDLFKPIGERKFDLIIFNPPYLPVSRSELTGIQLEKAWAGGSTGRKIIDRFLDDLLIHLEPEGRSLFVQSSLSGIRETFKKLHQMELQVTTKTEKLSFERIYLFQVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF77</accession>
    <name>A0A133VF77_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_00020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05092">
        <property type="protein sequence ID" value="KXB05092"/>
        <property type="gene ID" value="AKJ48_00020"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.4"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012840">
        <property type="entry name" value="NrdG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01094">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02495">
        <property type="entry name" value="NrdG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="30"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB05092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="252" mass="28995" checksum="C4BBFC0F68D136CF" modified="2016-07-06" version="1">MKKPHSKKSLSENRCNRMKLRGLLPLSLIEYPGKMVAVVWTGGCNFRCPFCYNRDLVLNPTSIDPVSEGEVLGLLKRREKWLDGLAITGGEPTIHEDLPEFIKRVKDLDFLVSIETNGSNLEMLKKLIEDELVDYIALDVKAPLDWDRYKTVAGMDDKNKFEEVLKSVKLLKEGKVDYEFRTTFVPNLLDGEDIITIAEQLKGVKRYALQQFTPRNTINEKFEKLEPIAQEELEKIGEKIEGMFQDFRIRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF82</accession>
    <name>A0A133VF82_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Box A-binding protein</fullName>
            <shortName evidence="4">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">TATA sequence-binding protein</fullName>
            <shortName evidence="4">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tbp</name>
        <name evidence="5" type="ORF">AKJ48_00010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05090">
        <property type="protein sequence ID" value="KXB05090"/>
        <property type="gene ID" value="AKJ48_00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="2" evidence="4">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB05090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="177" mass="19837" checksum="DC6044FC2F03A7DD" modified="2016-07-06" version="1">MAKVDTEIQNIVLSVTYKDIEFDLEKLASVLEGARYDPEVFPGIAYKSETPRASFLIFASGKMNCVGAKSMKDAEQAIKKLTDKLRSSGVDIKEEPKVKVQNMVASFDFNREFDLEKIAREFRNTEYEPEVFPGLVFRLDEPEVVVLLFVSGKGVCAGAKSMKDVKRAAKKITKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF84</accession>
    <name>A0A133VF84_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05095">
        <property type="protein sequence ID" value="KXB05095"/>
        <property type="gene ID" value="AKJ48_00035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="179" mass="19584" checksum="CF441C1FF5CCE6DF" modified="2016-07-06" version="1">MITEFEGKTPQVHETAFVHPRATVIGDVEIGKHSSVWPGAVVRADFGKVRIGDYTCVQDNTVIHPADSYTEEGPKYIPVEIGDRVIVGHRSLVHGAKIEDECIVGGGAIVFNEAIVKKNSLVGMGAVVLKETEVQPRTIVVGIPARPLRKLNDSEIERIRIQAENYAELASRYREAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF89</accession>
    <name>A0A133VF89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05101">
        <property type="protein sequence ID" value="KXB05101"/>
        <property type="gene ID" value="AKJ48_00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="142" mass="16247" checksum="5048ED8C182BA2A4" modified="2016-07-06" version="1">MFRFLRTKRRFGVDAIFAIILALTYWGFHSGLSAISSDVNTLFLATYLFLGLGVLVLYLVSDMNPEFASIVHVGLFPFFSLIFIFAKWMPDVIPELNGIEMSFSLAMLAYTLLMIVFFTVQLLIHQSEPEPQEVRRMKGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF91</accession>
    <name>A0A133VF91_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_00190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05118">
        <property type="protein sequence ID" value="KXB05118"/>
        <property type="gene ID" value="AKJ48_00190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.34"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="68"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB05118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="340" mass="38617" checksum="BE638B2CB619FA7A" modified="2016-07-06" version="1">MKKPAKYWEEMPDNNVRCTLCPRKCVITPGKIGYCQARKNENGELFTMVYGEATSLTPDPIEKKPLYHFYPGTRVFSMSTAGCNFECKHCQNWTISQSSVEEIGTEQVTPEQVVEYTQRSDSQGVAYTYGEPAIWFEFCLDAAKLVHKAGLYNVYVTNGYMELDAWKEIKPYLDAMNVDVKAFDDEFYQKVCGAPSVQPVLDTCEWAVENGVHLEVTNLVIPGENDDPEQIRELCQWVANDLNPSVPIHFSRFHPMYKMMDKSSTPVETLEKALKIAKEEGLKHIYIGNVPSHEADNTYCPKCGELLIRRRGFSVSEYKLEDHNCPKCGAEINIVGEYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF93</accession>
    <name>A0A133VF93_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="3">DHBP synthase</shortName>
            <ecNumber evidence="3">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_00180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05116">
        <property type="protein sequence ID" value="KXB05116"/>
        <property type="gene ID" value="AKJ48_00180"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.32"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB05116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="236" mass="25612" checksum="61AA2324F35A9FD3" modified="2016-07-06" version="1">MNLNQALDAIRKGEFVLISDSPDREGETDLVIAAEKVGPAHIAKMRRDGGGLICVALHPKIANNFGLPYMTKIYESASPTHEVLNATTPDDIPYDERSAFSITVNHRQTYTGVTDSDRALTIRELGKLGSGSFDGPAIKEFGREFRSPGHVPILRAAGELVAERQGHTELAVALMEMAGVTPVAVVCEMLDAETSEALAGNRVKTYAEDDDLVLLDGEEIVRAYSDWSEQDPQEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF95</accession>
    <name>A0A133VF95_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LAGLIDADG_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05112">
        <property type="protein sequence ID" value="KXB05112"/>
        <property type="gene ID" value="AKJ48_00150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAGLIDADG_2" evidence="1">
        <location>
            <begin position="176"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="278" mass="31562" checksum="108514744D47C8F5" modified="2016-07-06" version="1">MKAISHRLASRVKHLRRNGFSYKEIAEKLPVSVGTSYNYAKDVKVMPAGMKRLKSRQGNGRPPKEVSIVKELTVEKTRIISHCLFDGSVIINNGDYVVKYTNASHGLIRQFVSGMRKIYGMSPGDIRLYQGKNHPWWEVMYRSKRVVEDLLRYSPTYSTSNNVGLPKGIARKRKFIQTFLRAFGDDEGCIAQSGALTLYSNSRRLILDAKQLHEKLGIRCSVYRKKSCFVLRVKGGLENLRRFQRKVGVTESIIVRGKAIGSKKRAVLANFLASYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB0</accession>
    <name>A0A133VFB0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05138">
        <property type="protein sequence ID" value="KXB05138"/>
        <property type="gene ID" value="AKJ48_00245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="94" mass="10733" checksum="006CF3ACD780309C" modified="2016-07-06" version="1">MKVLTARVDEEIIKDLDEIGEEEKADRAEVARRLLDKAIKEWKLNRALEMISGGTWTMRRSADYAGLSYYQMLEEMSTHGVDSGPTLEDLRQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB6</accession>
    <name>A0A133VFB6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05133">
        <property type="protein sequence ID" value="KXB05133"/>
        <property type="gene ID" value="AKJ48_00295"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.54"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="105" mass="11811" checksum="85945472BE957A3A" modified="2016-07-06" version="1">MELTDKNFEEEVLKSELPVFVDFWGSWCPPCKMTEPIVSELEKEYDGKVKIGKLNIDKYPSVASRYAISGVPTFITIKNGKEVAREIGAKSKKQLRELIESALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9B6</accession>
    <name>A0A133V9B6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000092">
        <property type="protein sequence ID" value="KXB03021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03021">
        <property type="protein sequence ID" value="KXB03021"/>
        <property type="gene ID" value="AKJ48_04310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.930"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="85" mass="9316" checksum="F14ED9C319F1FB8D" modified="2016-07-06" version="1">MPPKKILLSTTKMLSCFFPIKMDPSSIPERYQVLDIETTALEPEAGLITAIGHGLPPLDTVFLVARLMSSAAPVKLIYSDGWARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9D7</accession>
    <name>A0A133V9D7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000090">
        <property type="protein sequence ID" value="KXB03056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03056">
        <property type="protein sequence ID" value="KXB03056"/>
        <property type="gene ID" value="AKJ48_04275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="111" mass="12765" checksum="DE981E709B672248" modified="2016-07-06" version="1">MEFGAGFWGPIIATGVMLFGVFIGWLILRGSQRITPPRPTKEKITTYACGEESRIEETQASTEQFYSPVRRVFSGFYRYIRPSHSGDLRTYLLWIVSGFVIILIIIVLAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9K5</accession>
    <name>A0A133V9K5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000085">
        <property type="protein sequence ID" value="KXB03133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03133">
        <property type="protein sequence ID" value="KXB03133"/>
        <property type="gene ID" value="AKJ48_04180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="140" mass="16109" checksum="8B5849E8B49784FA" modified="2016-07-06" version="1">MILASPDPIRGVDEPTQEIIGKQKYRFDGRKERERFKLCWSARSVVYPELEMKQNHNGEYEPTDLFGVLTHAALTNDFVNDAAETYPLPEDETPHPNTVFYRIRNLSVVEILDQFNSAIFFVFLSSVLRGREGCPVLFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9N2</accession>
    <name>A0A133V9N2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000083">
        <property type="protein sequence ID" value="KXB03168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03168">
        <property type="protein sequence ID" value="KXB03168"/>
        <property type="gene ID" value="AKJ48_04165"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.881"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="131" mass="15681" checksum="3A61A0C788C9A654" modified="2016-07-06" version="1" fragment="single">GIRLVPRYCSLQPVNDILTYFDTHLHHLLTLASEVEVEYNKLYIRSQKTKWASCSSKGNLSFNLRAAILPRELMKHLVLHELIHLKKSKHDKEFWKLIGRYHPDYEEKEESLVRYWFLAHKNKPWNKIIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9R1</accession>
    <name>A0A133V9R1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000083">
        <property type="protein sequence ID" value="KXB03169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03169">
        <property type="protein sequence ID" value="KXB03169"/>
        <property type="gene ID" value="AKJ48_04150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="117" mass="13983" checksum="0AC58DC346C86CC7" modified="2016-07-06" version="1">MSTINMFHAHDAYMFKHYFDDRNLFEELRQHYDSLEYRFEVRESEVESVMEKLRAYGYEVNVVERDEIPDYTVIIGKYVRHKDLLRNAVDVIELGDEKALVMKDMASREVALDRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9Y2</accession>
    <name>A0A133V9Y2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_04065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000078">
        <property type="protein sequence ID" value="KXB03252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03252">
        <property type="protein sequence ID" value="KXB03252"/>
        <property type="gene ID" value="AKJ48_04065"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.834"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02166">
        <property type="entry name" value="NMNAT_Archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB03252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="176" mass="20221" checksum="D17890C1F633219A" modified="2016-07-06" version="1">MVKRAIMLGRFQPPHNGHLEVISQILEEVDELVIGLGSAQLSHELDDPFTAGERILMLTKSLDEADIDLSRVYFIPIPDVNNNALWVSHVLSQSPPFTHVYSGNPLVKRLFKERGFDVETPPLFKREEYQGTVIRERMLKNEEWQNLVPKAVVEVISEINGTERLKELKETDYLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA64</accession>
    <name>A0A133VA64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000074">
        <property type="protein sequence ID" value="KXB03333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03333">
        <property type="protein sequence ID" value="KXB03333"/>
        <property type="gene ID" value="AKJ48_03990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="145" mass="16566" checksum="24B6A70A18EECDDF" modified="2016-07-06" version="1">MKNWWELINMVTKNSEQRFNDEDLSALVSLFNVLGNKERLSIIKSLENRAKRFSSFSKKRDVNLNAVNENLRALLSHGIIFKTHGRENYDLTPKGHAILRVLIDGGLNLLKHLSPTDSKITCLSDQQMEARYVYDSAKSIPGLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA73</accession>
    <name>A0A133VA73_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000074">
        <property type="protein sequence ID" value="KXB03336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03336">
        <property type="protein sequence ID" value="KXB03336"/>
        <property type="gene ID" value="AKJ48_03985"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="63"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB03336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="157" mass="18235" checksum="6A6FA6E5F1A26C25" modified="2016-07-06" version="1">MKFSGEDVEILRRLQTNFPIEERPFRSLSSELGITEDKLIERIREYKANGYVREISPKLVSDKVGYSASTLVAVKVEEDRIEEIAETINEYDGVSLNYERDNDYNLWFTLHASSKEELLEIIDEIKKRTDPINLLNLPKQKQFKLHVVFNPLTGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAH9</accession>
    <name>A0A133VAH9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000071">
        <property type="protein sequence ID" value="KXB03405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03405">
        <property type="protein sequence ID" value="KXB03405"/>
        <property type="gene ID" value="AKJ48_03915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="86" mass="10373" checksum="5C0AE786609DB70C" modified="2016-07-06" version="1">MMSVTIKDVDENVYKNFKAEAVRRGLKVSEAATEAFRFWASLKKPRRVRNWSRIKKASKDIDRLREKSESKWSGTEEIRKWRDRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAL5</accession>
    <name>A0A133VAL5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000067">
        <property type="protein sequence ID" value="KXB03496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03496">
        <property type="protein sequence ID" value="KXB03496"/>
        <property type="gene ID" value="AKJ48_03840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="98" mass="11431" checksum="9434C7108F01FACA" modified="2016-07-06" version="1">MAKSVGIRMDEDLLKKLDRISKEENLDRSTLVRKLLSRGFESFLKERAAEKYKRGEITLSKAAEEANITLWEMEEFLIESGYISKYSIKDLKQEITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAL9</accession>
    <name>A0A133VAL9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000069">
        <property type="protein sequence ID" value="KXB03447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03447">
        <property type="protein sequence ID" value="KXB03447"/>
        <property type="gene ID" value="AKJ48_03870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019216">
        <property type="entry name" value="DUF2116_Zn-ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09889">
        <property type="entry name" value="DUF2116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="68" mass="7570" checksum="6A66C8D772E8976E" modified="2016-07-06" version="1">MAKETEDHRHCIACGKVTPPDTFICSEECEEKLKSHQDQMKRKRNLQIVFLVALVAAVIILSFVVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAV9</accession>
    <name>A0A133VAV9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfe</name>
        <name evidence="6" type="ORF">AKJ48_03770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000064">
        <property type="protein sequence ID" value="KXB03586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03586">
        <property type="protein sequence ID" value="KXB03586"/>
        <property type="gene ID" value="AKJ48_03770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006373">
        <property type="entry name" value="TF_E_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00373">
        <property type="entry name" value="TIGR00373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB03586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="172" mass="19979" checksum="A25CDFD7FCA02A95" modified="2016-07-06" version="1">MEAGELAQTPAFKKVLSRIAGEHGVEIAEVLIDNGEATDEEIANETDIRLNLVRKILYDLYDNRVVSYKRSRDDETGWYVYHWRIEPDRALELLGENERTLLRKLQKRLDHEKNTMFFNCENDHSRVEFDEAVATDFKCPQCGKRLESFDNSGIINALERRIEALKRDFAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAW6</accession>
    <name>A0A133VAW6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000065">
        <property type="protein sequence ID" value="KXB03554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03554">
        <property type="protein sequence ID" value="KXB03554"/>
        <property type="gene ID" value="AKJ48_03790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="314" mass="33994" checksum="5D89BADBB6BB2658" modified="2016-07-06" version="1">MSIKLITVGDANVDFIVSVNSLPEKGGETRVPTFEMHAGGSAANTCVAAQRLGLKSGFIGRVGSEFFGRFLKREFRKEGVDISQLQTDGKVNSGFMFIMTTPDGERTMLCSRGANTRLALREIDTDYVKDTNNLHISGYSFLEPPQRDAVRQVVKVAENEDCQISLDPGILALKESLEEIESIMPSVDLLFLNKRELRILSDIEDIEVAGRQFLEMGPSTVVLKLGGEGCLALAKGRKSFAKAFPINIVDTTGAGDAFDATFIVGLERGWDLNKITKFANATGAISATKIGARSALPTFSEVEKFLSGEAGVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB45</accession>
    <name>A0A133VB45_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTP_transf_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000061">
        <property type="protein sequence ID" value="KXB03688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03688">
        <property type="protein sequence ID" value="KXB03688"/>
        <property type="gene ID" value="AKJ48_03680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="116" mass="13197" checksum="A6ED1AD11E6B30CA" modified="2016-07-06" version="1" fragment="single">MKHEKVVVGGTFDYLHDGHKAILRKAFELGNQVLIGIVSDQMELKKDSVGIPPLEERKSKLEEFLEEQDWLERAEIVVISDPIGPAAEDRELEAIIVSEETRSRAEEINEIRESND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB62</accession>
    <name>A0A133VB62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000061">
        <property type="protein sequence ID" value="KXB03691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03691">
        <property type="protein sequence ID" value="KXB03691"/>
        <property type="gene ID" value="AKJ48_03695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="180" mass="20263" checksum="CB7D977D3D515A9D" modified="2016-07-06" version="1">MKSAVLIIDMINDFVTGRFENERAQKIVPNIKKLLETARSEKIPIIYVRDAHPEDDSEFDIWGPHAVAGSEGSEVIPELESGEGEPVLDKTKYSAFFNTNLNSILENLEVEEVVLTGVLTDICIQHTAADAFFRGYKVIIPRECVDSLSDEENKRAIKFIEKMYGAEISNLKDLLEKMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBE9</accession>
    <name>A0A133VBE9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol-3-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000059">
        <property type="protein sequence ID" value="KXB03776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03776">
        <property type="protein sequence ID" value="KXB03776"/>
        <property type="gene ID" value="AKJ48_03655"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.701"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="192"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="357" mass="38829" checksum="E05BACB47C019475" modified="2016-07-06" version="1">MGKVKVAIAGVGNCSSSLVQGVEYYKDADEGQFVPGLMHVNFGGYHINDIDFVAAFDVDANKVGKDLSEAIFTKPNCTIQFSEVPELGVEVMRAEVQDGIGKYLKGVIPVDKTQESVNVAQILEDADADVLISYMPVGSFEASRYYAREALKAGCGFVNCIPEFIVSDKEWGEKFEEAGVPCAGDDIKSQVGATILHRAIATLLHDRGVKLDESYQLNVGGNTDFLNMLEEERLSSKRVSKTEAVATQVPYEVPLKIGPSDYIPFLDDNKVCHIYAKGRKFGDVPLEIDVKLSVEDSPNSAGVVIDALRAVKLAKDRDVGGPLTSISAYCFKHPPIQIPDSEAVQAVEEFIAGERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBP6</accession>
    <name>A0A133VBP6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000057">
        <property type="protein sequence ID" value="KXB03873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03873">
        <property type="protein sequence ID" value="KXB03873"/>
        <property type="gene ID" value="AKJ48_03605"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.690"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="103"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="404" mass="44879" checksum="2BA5901D2640DCF4" modified="2016-07-06" version="1">MDLIIRDARIFGESKIKDIGIKDGKIAKIGKITEDADEEIKADGHLTSPSFVDPHIHLDKVLTADDLPPNKSGTLQEAIELIGERKREYTIEGIKARAKKVIQSATRNGTMKMRTHVDVDTIGELTPLKGLLAMRREVEEDIDLQIVAFPQEGVVRDPGTEELLRKAMSEGADVIGGMPHHEKSPEEMREHVDVIFEIAKEFDADIDMHVDETDDPNSRSLEYVAKKTIEEEYEGRVTAGHACALAAYPDDYARKVIEEVKKAEINVITNPATNLAIQGREDDQPVRRGITRVKELLEAGVNVTFGQDCVSDAFYPFGKADMLEVALITAHAAHLTMPEEIETVFRMMTYNAAQTLGVEKEYGIKVGRPADLVITNAPNPKEAIRLQPDRWVIKRGTILASPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBX7</accession>
    <name>A0A133VBX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000056">
        <property type="protein sequence ID" value="KXB03930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03930">
        <property type="protein sequence ID" value="KXB03930"/>
        <property type="gene ID" value="AKJ48_03590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="90" mass="10177" checksum="0C0F16A0199DB130" modified="2016-07-06" version="1">MVKRNEDKKKRWNPFKSLDKKLNEMTKGFGGAGAGHSISIQQGPNGTRIDVSGDVDIDKLKERYGKDAKIYKDGKRVDKPLIEVIEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBY6</accession>
    <name>A0A133VBY6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000056">
        <property type="protein sequence ID" value="KXB03927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03927">
        <property type="protein sequence ID" value="KXB03927"/>
        <property type="gene ID" value="AKJ48_03575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="190" mass="21515" checksum="D5FA8496ED1B224B" modified="2016-07-06" version="1">MIGAVILAAGESKRMGRPKLLLEVKGERVIDRVVNSFKDVADEMVVVLGHEPENLIPILGELEVRWEINEEYQEGMVSSIKTGVKTLKDCEALFLALGDQPIIKQDFLNAAIDAWKNGAKLVSPIHEGKKGHPVLFDRSLFEEILSLKREETLRKVIHEHDEDHELIDAGEWAIMDFDTPEDYQAVKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC31</accession>
    <name>A0A133VC31_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000054">
        <property type="protein sequence ID" value="KXB03975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03975">
        <property type="protein sequence ID" value="KXB03975"/>
        <property type="gene ID" value="AKJ48_03500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="181" mass="20012" checksum="FADE164BBB8D3EF9" modified="2016-07-06" version="1">MLELNGSFGRRVLAITGAHAHVEDVESVIRKVRKISRANEVVSQIFNAKHIAGRQHLIHAARLALIAQEDGRNFADSQSIELTCWTAGLRQINQALERVGLRKGSAEVAILTIGGKEEKVKKAREEILHELGAKQDEGVLDLTPEKEPTLIRDFGISESELEVANLQSLVLERVALLSLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCA7</accession>
    <name>A0A133VCA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000050">
        <property type="protein sequence ID" value="KXB04086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04086">
        <property type="protein sequence ID" value="KXB04086"/>
        <property type="gene ID" value="AKJ48_03390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="69" mass="7769" checksum="5CC9B23DEA1689A9" modified="2016-07-06" version="1">MSNFWRIPIRGRIIQQTTRETVFKTRKLENKIGNLWIGGVLLPDGVHGDPPSCLAVGVRVRWLAGSQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCB5</accession>
    <name>A0A133VCB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000050">
        <property type="protein sequence ID" value="KXB04089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04089">
        <property type="protein sequence ID" value="KXB04089"/>
        <property type="gene ID" value="AKJ48_03400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="SSF64076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="124" mass="14436" checksum="85C98C0EF7B19F76" modified="2016-07-06" version="1">MNIEETGFGWITIDGKKYDHDLVIYPNAIEERKKWITKEKHGTSHMFTRKEMEEYLKNVEPEEIEVVVIGTGQYGKLGLLDEAKKLLEENEIEAVELKTPKAVERFEEGEEPRSRKLGIFHVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCB7</accession>
    <name>A0A133VCB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000051">
        <property type="protein sequence ID" value="KXB04060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04060">
        <property type="protein sequence ID" value="KXB04060"/>
        <property type="gene ID" value="AKJ48_03425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="91" mass="9998" checksum="579E58BBED941FCD" modified="2016-07-06" version="1">MQEESFELFLNLFPVILYTVKGLNPTYVLYGLVLAGSLTFGLEAFLIGFGGRLSTIYQSEKWRLLGVTLLLGLAITITSIGLMLILGLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCD7</accession>
    <name>A0A133VCD7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000050">
        <property type="protein sequence ID" value="KXB04085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04085">
        <property type="protein sequence ID" value="KXB04085"/>
        <property type="gene ID" value="AKJ48_03385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="70" mass="8074" checksum="FFBE9CBD268261AA" modified="2016-07-06" version="1">MSGELDSISERLDEIEARLEKLEEARESSGTKAKELQNKATTKPAARVNHNYLKRTIEEAKKRFEKERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCL1</accession>
    <name>A0A133VCL1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpB</name>
        <name evidence="11" type="ORF">AKJ48_03325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000048">
        <property type="protein sequence ID" value="KXB04144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04144">
        <property type="protein sequence ID" value="KXB04144"/>
        <property type="gene ID" value="AKJ48_03325"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.601"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="9">
        <location>
            <begin position="135"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB04144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="464" mass="51928" checksum="CDDBBCF6D08D85D6" modified="2016-07-06" version="1">MVEEKTREYRTVAEISGPLMVVEDVEGVGYDEIVEIETPEGVEKRGQVLEVEEDRAVVQVFEGTSGIDTSGTKVRFTGSTIKFPVSMDLLGRVFSGKGLPRDGGPHIIPEDELDIHGAPINPAARDYPTDFIQTGISSIDGMNTLVRGQKLPIFSGTGLPHSELAAQIARQARVLGEEEEFAVIFCAMGITHEEASFFRKDFERTGAFERVTMFLNLADDPAIERILTPRIALTAAEYFAFTQGMHVLVILTDMTNYGEALREVSAAREEVPSRRGYPGYLYTDLATIYERAGRVKGKKGSITQMPILTMPSDDITHPIPDLTGYITEGQLVMTRELHRKGIYPPINVLPSLSRLMKDGVGEDKTREDHEGVSNQLYSAYAEGRDVRALVEVVGEAALSERDRRYLEFADKFENNFVNQETDENRDLEQTLGMGWDLLSELPEEELKRVEPEYIEKYHPARQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCP6</accession>
    <name>A0A133VCP6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_03250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000046">
        <property type="protein sequence ID" value="KXB04222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04222">
        <property type="protein sequence ID" value="KXB04222"/>
        <property type="gene ID" value="AKJ48_03250"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.583"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="9"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="512" mass="58814" checksum="9AEA2F1A7CCBFB61" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCW8</accession>
    <name>A0A133VCW8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="2">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">truB</name>
        <name evidence="5" type="ORF">AKJ48_03095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04298">
        <property type="protein sequence ID" value="KXB04298"/>
        <property type="gene ID" value="AKJ48_03095"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.553"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DKCLD" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="3">
        <location>
            <begin position="247"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="331" mass="36988" checksum="A5DF88D7EF04B389" modified="2016-07-06" version="1">MAFLGKLPADTPREVLIRARDFTNPDHGCEPSARSMTEHLRFGVINLDKPIGPTSHEVVNWVKRLMKVNKAGHGGTLDPRVSGILPVALQEATKLTQTLLPAGKEYINLIHLHRDVPDHKLEQVLAEFEGEIYQRPPVRAAVKRRLRKRKIYYIELLERENRDALLRIGCQAGTYIRKLCHDIGRVLGCGAHMAELRRSRTGPFTEDDTLVNLHDLADAYAFWKEDGLEEPLRDAVQPVEKSVEHLPKIVVRDGAVDALCHGASLAAPGVLSVETGISIGDLVAEMTLKGELIALAKSEMTSRKIQEAEHGIIAKPERVIMNPDTYPRKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCX7</accession>
    <name>A0A133VCX7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_03030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000041">
        <property type="protein sequence ID" value="KXB04308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04308">
        <property type="protein sequence ID" value="KXB04308"/>
        <property type="gene ID" value="AKJ48_03030"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.541"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="255"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="503" mass="56197" checksum="F6A1E0E50216E40A" modified="2016-07-06" version="1">MRVEDIEKGFPGVWEHLILDEINLDVKAGEIHALLGENGAGKTVLANIMSGFYLATGGQIYIKGEPVTLKSPKDALDRGVGMVHQELTLARPLTVAENVALGLSKSNFSLPLHEVEEKIRELSQRYGLKVDPKAKIEDLSAGEQQRVEILKVLFYEPDVIIMDEPTSVLTPQEVDDLFSSIRALADEGHGVLFITHKLHEALELGDRITVLRLGKLVGIKDPSETDEEELTQMMLGKGFPIQLEREPVKSDRMALETRNLRALNNRGILALKGVDLKLREGEILGIAGISGNGQTELIEVITGLREAQEGEVKIFGDDVTDKSPREILDKDVAHIPEERRRVGVAEPFSTAENMILKDYRDDQFSKWSFLDRSFITEHADELVDEFNILAPDLWRTENRILSGGNIQRLILARELWREPRLIIASHPTHGLDRKAIKHTWELFMHLRDDGSSILLVSEDLDEILSLSDRIAVIYDGEIVGRMDAPEADKEELGLLMMGAGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD03</accession>
    <name>A0A133VD03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04297">
        <property type="protein sequence ID" value="KXB04297"/>
        <property type="gene ID" value="AKJ48_03090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="286" mass="30767" checksum="B82BB6A1F8CCAB3E" modified="2016-07-06" version="1">MELLALTLVLGATLCWGAAQVLGKIALRKIDSLLFNWIRFTIAILPIILGATIVGELGGIGLNSATLVAIASGVFGWFLATYLFFYSMKREAAHRMMPTGNAYPFWAIALAFIFLGEPLKIILPLSAIMIFSGTLLLSLKEKEAEHWKWGVPIASFVAFLWGANAILNKYCLSQGMDVYTLLLVRLLSAAVLFTIALGITSQRGKIKAHHGSVKLSIASGLIAFPIGALLYLSALQTEGASVLAPITGTTVLFGFLLSILVLGEKPTRKSILGMLLIFSGILIMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD38</accession>
    <name>A0A133VD38_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ48_02995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="LHYB01000040">
        <property type="protein sequence ID" value="KXB04314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04314">
        <property type="protein sequence ID" value="KXB04314"/>
        <property type="gene ID" value="AKJ48_02995"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="296"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB04314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="392" mass="44445" checksum="AFDDF99605522340" modified="2016-07-06" version="1">MSKVEIGVIGLGKLGLPLALLFSKRFKVSGVDISEQRIDQIKNRQDFYEPQVNEYLEDYGDNLRTSTDYKILEDCDVVFIIVPTPSLPSGKFDLQYVESALRQMHKVNPECLAVISSTINIGDMEKLKQIHKRLCYNPEFIKQGSIINDFENPKFVLIGAYEEGDGEQVAEIWSKMNDRPIQIVSPAEAEITKLSLNVSFTLGITFANMIGELCEKFDADSDKVLNIIYKDRRNYKAGLGFMGPCFPRDVTCFETICTEKSIESGYRFANLINDLNSYTVGRWLRKIKSHNKEKIGVLGVAYKPGVPYIYESQPIKIIQQLQTEDHEIYVYDPLAQENAKRVLGSSVHFCSSIGECLDEAEVIFIGTPDYADVDTNKHVVNPWSREIWSTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD45</accession>
    <name>A0A133VD45_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_02775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04378">
        <property type="protein sequence ID" value="KXB04378"/>
        <property type="gene ID" value="AKJ48_02775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="SSF160350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="103" mass="11491" checksum="EC176C9EBA2B345D" modified="2016-07-06" version="1">MGAPQKFRSRYIAFKVEGEASIEELRKAISKSSREISRLNPRPRIVIYDGDEGCGLVKCSHLQVDELKRKLKKIGGTGNESFKVRLLGVSGTIKAAKRKFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD49</accession>
    <name>A0A133VD49_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psmA</name>
        <name evidence="5" type="ORF">AKJ48_02780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04379">
        <property type="protein sequence ID" value="KXB04379"/>
        <property type="gene ID" value="AKJ48_02780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.459"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="4">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="240" mass="25834" checksum="938F8EFA9C4D9BE8" modified="2016-07-06" version="1">MAFVGRGRGYDRAITVFSPDGKLFQVQYAQEAVKRGYTALGVKVNSGVVLAAERRSPSKLVEDGSVEKIFQVDDHIGAGASGLIADARVLIDRARIEAQVNRMRYDEPIPVETLSRSIGDIKQMYTQHGGVRPFGTRFLIGGVDANGPQLYETDPSGVVAAYKAHAIGGGAAGAIEVLESRYEEDASLDDAISLALDALKTVIEGKLGSDKVEMTIIPAETEEFEKLSKDKVDEYIKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD72</accession>
    <name>A0A133VD72_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_02735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000034">
        <property type="protein sequence ID" value="KXB04392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04392">
        <property type="protein sequence ID" value="KXB04392"/>
        <property type="gene ID" value="AKJ48_02735"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.449"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="4">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="302" mass="33205" checksum="AB044BC82A7F115C" modified="2016-07-06" version="1">MEIKLRRSQLAVPGSNPKMIEKGSESDADEAFLDLEDAVAPTEKVDARGNVIEGLQEHDWSEVRPCYRINGVDTKWWYNDVIEVVREAGEHLDTLMIPMAADAVDVKIVDRLLTQVEANHGLPEGGIGLQVQIETAEGMTNIKEIAEASERLETLIFGPGDYAASVGAASLTIGAEEGYPGHYWHYQLARIVHVAKAHGLQAIDGPFSEIENIEGFRKSCQNASSLGCNGKWAIHPLQIEPANEIFAPKEDEVEKAQKMIKEYEKAQEKGLGAISFEGEMIDEAAHKMAKNTIEKARKAGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD76</accession>
    <name>A0A133VD76_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000033">
        <property type="protein sequence ID" value="KXB04406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04406">
        <property type="protein sequence ID" value="KXB04406"/>
        <property type="gene ID" value="AKJ48_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="98" mass="11090" checksum="07F8D5BB52731029" modified="2016-07-06" version="1">MKTVEIEKGEFSREELSLLESLGGENERARGAISTILHESLDASLEEVRVEDQVIVRVFPHRKYAALDPGDVRRAIGAEIRPYLRERGTPKTPPRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDA9</accession>
    <name>A0A133VDA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000031">
        <property type="protein sequence ID" value="KXB04430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04430">
        <property type="protein sequence ID" value="KXB04430"/>
        <property type="gene ID" value="AKJ48_02600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="237" mass="27289" checksum="5BA5345A4A3848D2" modified="2016-07-06" version="1">MVNPAKVFRITEDADLGFIAQKLKDFREEETYETEDEETKELVTEVLDLELEEDKLTGVFSRDFVRSRYYRRGLVETLVTEEAPFWVREFRGQNFLVVLAPSVARGVKKLLTNHVANKLSEVIFLKSGLIVEAKIAHETLKELHESNPRATKLIWFDNIDFPDVGKLCLSGSALADTKLYHEYLDHGKIWYAVFEAEKYGFVVGVTRNCVITLFSKATVDEFSDYILKEIIPLVEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC3</accession>
    <name>A0A133VDC3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04442">
        <property type="protein sequence ID" value="KXB04442"/>
        <property type="gene ID" value="AKJ48_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="191" mass="21356" checksum="1D27B6C517339618" modified="2016-07-06" version="1">MTDFPVIGVVGLQASGKTEVAKRMMQLGASRVRMGDVVWNEVKNRGLKVSEEKVAEVANELREKEGPAAIAKHCIPLIKEKGKESKAVIVDGIRSDSEVEVFKNAFGENFSLISVEAAENTRYNRVESRGREDDIGDWEAFRAKDEQELGWGMGEAMEMSDFKIINEGSLEDLWDKATEVFEEITGRKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC4</accession>
    <name>A0A133VDC4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F420_oxidored domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04448">
        <property type="protein sequence ID" value="KXB04448"/>
        <property type="gene ID" value="AKJ48_02565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="216" mass="22828" checksum="D3B3F84A765A582D" modified="2016-07-06" version="1">MIAVIGGTGKLGQGLVARLAMAGEEVIIGSRTPKKAERVAKELSEKIGEKIKGTGNEEAARQAELVILSIPFKGMEKILNQIKPALNPDKIVVSVIVPFSFEEGWAVLSQSKSGSAAEEVASRTPKNVPVISTFQTASANRMRDLGEPLSADVPVCGDDEDAKNQVIELVEKLPGARAIDAGPLANSALTEAVGVLLIDLTRRHGVKRIGLKFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDD4</accession>
    <name>A0A133VDD4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04458">
        <property type="protein sequence ID" value="KXB04458"/>
        <property type="gene ID" value="AKJ48_02465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.356"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="236" mass="25184" checksum="C778409FE70B685A" modified="2016-07-06" version="1">MTAGVLGITHGLEPDHLAGIISLTGSEGDSRSSALIGTIFALGHVLLVFVWLLGAFFLIENISLGESLTIIGPAITGVILIVLGVGLGVAGVRKLVHRHFHTHDGEKHEHYHLHIPLISRDSHDFTSRHSHEHAKREYLKIGLLGALFTLSPPLSMIAFISVTLPMVGGTIITVAVIIYSIAIISTMGLIGGGIGKLFNLVKTQNEQIHALSQCIASIMIIGFAGYLIGHNFLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDD6</accession>
    <name>A0A133VDD6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH hxlR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04459">
        <property type="protein sequence ID" value="KXB04459"/>
        <property type="gene ID" value="AKJ48_02470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="108" mass="12665" checksum="9A5888F67BDDBC04" modified="2016-07-06" version="1">MRKEEYCPLTEASKILNRKWSLVIVGRLLNEEKRFSQLKKSIPEISPKVLSSTLKSLQKHGLIERKVVDSSPIKVNYHLTEKGESLEEIINNLEEWGEKWKKTRITFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDE2</accession>
    <name>A0A133VDE2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04468">
        <property type="protein sequence ID" value="KXB04468"/>
        <property type="gene ID" value="AKJ48_02515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="291" mass="31925" checksum="C22A09D3BCAF79C8" modified="2016-07-06" version="1">MVVYPYVVSLREGLEAALIIAILIGYLVRIKRPDLSKYVWWGVGSAIALSFGLGAGIWAVYGELGGVGEKLFEAGAAGTAVIVLTYMIFWMARNAKKIKGELEKKIDVSISRKWLLGITLLAFTAVFREGLETVLFLTASAFSNPAGTAIGATAGFATVIAIGFFLLRGTERLPIRKFFTITSILLLIFAAGILSYGVHEGIEAVEEAGHEVHWLEAKAYDFTPSTDSIFHPKEGAIGAVIQGLIGKIYLSPEWLTLIAYLLYWLIVGTYMLKVYAPTKFNGFIEKLFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDF4</accession>
    <name>A0A133VDF4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_02400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04479">
        <property type="protein sequence ID" value="KXB04479"/>
        <property type="gene ID" value="AKJ48_02400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="PTHR42198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="288" mass="32927" checksum="6E0C568EEE04C3D2" modified="2016-07-06" version="1">MNDFSKLALGITIVILLTSTFTGTVNAQGSERENYKNLLNTIDGAIRTFRLRGENSASMALKVAENQYGHFKSLYENTIRYDSRLSNLDNDINAKFDSLQQSPSVDGIRDLRGMVSEMANGLGVELSFLYKYAFIIILFVSLVLAFSVNMVSRTIVDWEKVNKVKRKSEELKNKLKKARREGKSKKVHKLMKEQQEFTKKHMGVLFSPMKTMLIIIIPFIIIFQLLSSTYGGWVVAWMPVNLPWPNLNIPLLSRFFPGTVASLSFFGWYLLSYFGFSMTLRRFLIPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDF5</accession>
    <name>A0A133VDF5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_02575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04447">
        <property type="protein sequence ID" value="KXB04447"/>
        <property type="gene ID" value="AKJ48_02575"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.379"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="337" mass="37019" checksum="48A85B111A013833" modified="2016-07-06" version="1">MFLLSGEHPTLPASEALATIETEGHESEVVEKLDQVLIAKTDADPEILAERLGMTHWIGEHYCTASPEEILDAVGSSDLIDNLPHGDSIAVKIKRVKQYSPKVDVKQLAKDVADQLLEEVDFQVDLTNPDNEITGVLTEDSCVLGVVKVRVNRSQFGKRRPKNRAAVHPGTLQPTFARGLVNLARTPRGGAFLDPFCGVGGILLEAGLIGAKPIGVDINPEMIEGTEKNLKEAGIKNFELQVGDARKLSIGEVDAIATDPPYGRQASTGGLELEELYEDSLPVLSKALKPECYLCISAPSQLDLEELAKDRDLEFKEKHEQRVHKDLTRNIYVFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDG0</accession>
    <name>A0A133VDG0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04461">
        <property type="protein sequence ID" value="KXB04461"/>
        <property type="gene ID" value="AKJ48_02480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="134" mass="15122" checksum="390455F43C102023" modified="2016-07-06" version="1">MSTNRFKRIDHVEIVIPSDEFDETIDFFSDVFGFKIKSRQGGPPDSQLREIVYMKLGGSVIELMSVENPDGISQSAFQTGYRMIAIEVDDMDGTMDYLEGKGIEITWGPKTIGESVRAEINTPGGLPIELREWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDG6</accession>
    <name>A0A133VDG6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000030">
        <property type="protein sequence ID" value="KXB04444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04444">
        <property type="protein sequence ID" value="KXB04444"/>
        <property type="gene ID" value="AKJ48_02555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="116" mass="13299" checksum="93476673AF67A9CE" modified="2016-07-06" version="1">MDVFKLDNILSYYSSLGVKVPKKHSKYGMIERWIGYLPVGFVLSWVLNLEMVLLIIIVTLALVGPIELYLMYRGFGPWKFFRGKPLKIVAKIFLLEAYNVVGYFLLGVLLQLLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDH9</accession>
    <name>A0A133VDH9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="8" type="ORF">AKJ48_02415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04481">
        <property type="protein sequence ID" value="KXB04481"/>
        <property type="gene ID" value="AKJ48_02415"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.346"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="30"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="148" mass="16292" checksum="83117F8FC8116281" modified="2016-07-06" version="1">MVVRKTRKTKKKRGSRTVGGGTVKKRRHSGHKGGKGLAGSHKHRWMKLTKKAPKHFGKHGFTRPPKLQKSVSTINVGELDERIDELLETEAAEQKEGKTIVDVTKIGIDKVLGRGKISRSMKVIAKNFSKSAKEKLEEAGGEVTTGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDI5</accession>
    <name>A0A133VDI5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04464">
        <property type="protein sequence ID" value="KXB04464"/>
        <property type="gene ID" value="AKJ48_02495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="264" mass="30139" checksum="55AB45906EA06DC2" modified="2016-07-06" version="1">MTKNPRQKRLDYFIEDLKNNDIEYVPKESDDSRVDWSKYDKAQVNELRDMILFIKDVVDKAVVRLGLDEAEEGSRGRPPYPPEDLAKGILIQQYFGVSNRVAEGFVDLFKEKLGIEESFSYKTLERAYDYPHVAMILMEVFKMTQDPVKDKETKFSPDGTGIPNSIKENWEKDSKSDEDGEGFTKMIAMLGTTRQLISAVRFPDNPYAHESPYFEPLLKETAETYSAVDRVSGDAAYLSRGNCDLVESVGGIPRFYLKKGITLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDL9</accession>
    <name>A0A133VDL9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000024">
        <property type="protein sequence ID" value="KXB04546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04546">
        <property type="protein sequence ID" value="KXB04546"/>
        <property type="gene ID" value="AKJ48_02235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="143" mass="16434" checksum="E3F8D4AD8D6B34C7" modified="2016-07-06" version="1">MVRKKGLLTNLTRFFTLSILSENPSHGYKIMDKLEERLGKRPSPGQIYPLLKKLKKKGLISQEIEKSGDRERKVYSLTEDGREAYSRLVNRFNDVVSTILEPRLTKCAHCGCQVYEGGHQEKIDGKLRSFCCIHCANSYKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDM5</accession>
    <name>A0A133VDM5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-Thr_ED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04553">
        <property type="protein sequence ID" value="KXB04553"/>
        <property type="gene ID" value="AKJ48_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-Thr_ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="135" mass="15179" checksum="800AF75F937AA39A" modified="2016-07-06" version="1">MKLLFNHVSNFEYRATEKTKIGTELEEGEKTGETGESILVKVCSESGDDDSTVERTLDEIKDISNQVGVKSLVLFPWAHLSQDLASPDAAEEMMEEMKKRLEGEGFEVLKAPFGWYKEWKLESKGHPVSVLSRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDR0</accession>
    <name>A0A133VDR0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04579">
        <property type="protein sequence ID" value="KXB04579"/>
        <property type="gene ID" value="AKJ48_02145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="131" mass="15633" checksum="A16E7CF38F4DA54B" modified="2016-07-06" version="1">MYRVEASSKPFCEWWNELTYSKVEKLLETNEMKREFIRGFYESEGTLNVPKRKSRRPSIKMATSDEELAKFVKSLLEELGYSPTFSQRKHEWNDRSWVMYHLRLSTSETQKFLKKIGSVIYMKSLSRVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDW9</accession>
    <name>A0A133VDW9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04631">
        <property type="protein sequence ID" value="KXB04631"/>
        <property type="gene ID" value="AKJ48_01905"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.212"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="257"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="479"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="604" mass="67438" checksum="D132274EEC17ED2A" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDZ0</accession>
    <name>A0A133VDZ0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04668">
        <property type="protein sequence ID" value="KXB04668"/>
        <property type="gene ID" value="AKJ48_01800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="301" mass="35188" checksum="427EFC65A863BB70" modified="2016-07-06" version="1">MPTLLEEKFRTNKFERKKRAFFKRFDWDFMPFSQKEPLPDPKLLVPHQIEEVRKSLDMVQEGDLVLFVVSEIGMGKTTLCKFLAETLPQEEDHDSVSVFLHGPSIEAPEQMARLILERLELQAREGDLASEFEQLRRWHENYPDLTLILIVDEFPDVDKSALELVREIADLEGIVWVLNGQEDQLIELVEDNAPALLDRRRYTLRLEPMSLEKVKELLTYRMAWVEEGDYNNRSIEPFTEEAIKEIHERAEGIPREALKLAGDAVYNAIKADAVIITKELVHEREEEKKSFWSFLPFFKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDZ2</accession>
    <name>A0A133VDZ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04666">
        <property type="protein sequence ID" value="KXB04666"/>
        <property type="gene ID" value="AKJ48_01785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="123" mass="13681" checksum="744CACA68458BFB0" modified="2016-07-06" version="1">MHEVKIAEKILGTLRNIAEKHQARVVKANLRIGELNEPDGVLLWLKKLGGKEFESTEFEITRVPIRVSCECGYTGRVESVAHYHGTNPELHIACPKCGGHDFSLTSGQEKEIVDVELEGEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDZ8</accession>
    <name>A0A133VDZ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04627">
        <property type="protein sequence ID" value="KXB04627"/>
        <property type="gene ID" value="AKJ48_01955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.219"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="484" mass="53524" checksum="C7F648C121AF1C7D" modified="2016-07-06" version="1">MASKVFAVFAIIVIGLVVILYFITPQEELGLPPSPEENIYSDGDNWSDFQELMFGSNSHLADTDGDGLQDDADRDPLTSINLEVLESAPTELDSENIRNAVDIWPKLFENTTQTIYLETYYVADSVPSKIYNALKGAGERGVKVKILLDKEMYEDDPSQADYLNSLKNIEVRTLNVGELSGGWLHSKYFVIDGRVAFVGSQNWSWTALEDGREIGALVRSKAFGEALVSIFEADWVKSGGSPLTPQRSNDTDGDSWPDDYERWVSTSRTNPDTDNDGIPNSRDSNPFVPLDTSVAGASVEWFYPVETAPTGDLDNPYIRDTENVLCELINSASENIRAQLYQYSTAGNYTMLDNALRKAANRGVEVKVLVDNKSHLNTDYPHPEVLDNLAIVPGISVKIIDIEAIGEWPGGGWVHTKVLSVDGERAYVGSANWFAPHMSHEITLGGWHAGPTRDVGIVFKSPETVRILENIFTQDWNSEYAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE05</accession>
    <name>A0A133VE05_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_01685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04686">
        <property type="protein sequence ID" value="KXB04686"/>
        <property type="gene ID" value="AKJ48_01685"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.165"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="8">
        <location>
            <begin position="88"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="372" mass="40361" checksum="422E8C6488B4DC1D" modified="2016-07-06" version="1" fragment="single">TGVHEVTAFAKGGVDESLEELEDTAQDLEGMTFEDLASFDEKCRELDGTKDLSKIGGNTIVALSMAMAKAMASTSGEPLYKYLLIGKSPRIPYPLGNVLGGGEHAGPTAPDIQEFLALPLGAESFHQAAFGNAKVHKKVKELILKKDKTFTGGKGDEGAWAPNLENQEALEILAKACEEISGELGFEIKPGLDVAASSLYDEESEKYEYSREGESRDTGEQIDFILELINTYNLTYVEDPIWEEDFKSFAEITKKVGQECLICGDDLFVTNVERIQKGIENNSANAVLIKPNQIGTLTDTRKAVELTKKNVGIPVMSHRSGETPDTTIAHLAVGYGCPIIKTGVVGGERIAKLNELIRVEDELGEEAQMGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE20</accession>
    <name>A0A133VE20_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OrfB_IS605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04644">
        <property type="protein sequence ID" value="KXB04644"/>
        <property type="gene ID" value="AKJ48_01870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="182"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="429" mass="51116" checksum="6375640FADB6869E" modified="2016-07-06" version="1">MKRVLRQNLRGLNSEEYETLKSMCRLSKNLYNATLYELRQSFFDNRGHLDYYSAWERLKENFNYEMLPSQAAQQTMMHVHRAFRSFFKLTEMKEKGEYEGEVRLPGYLDKDGFFSLNLPNQSFQVKKDHIRIGIPRSFRREFDCEMTEVRIPFTYEEVKNKRIKQLQVIPKAKAQHFEYRLVYEEEKTQIETEEKTWLSIDLNVDNLAVCGDHSGHSFILDGRKLKSMNRWYNREIARLQSIKDKQGIQGNTRRINELYRDRRNKIHDYFNKAVHWILEYCKANKIELVIAGENEEWKQKSRLGDKNNQNFVQIPFDLFKRKLKSKLELHGIKFERVNESHSSKCSFFDWESVEHHEEYVGTRIERGLFKTSDGTLVNADVNGYLNIARKYFEENKEEGKLKTLRGVESSGVVATPRRIREPFKVPAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE27</accession>
    <name>A0A133VE27_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_01620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04708">
        <property type="protein sequence ID" value="KXB04708"/>
        <property type="gene ID" value="AKJ48_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="126"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="470" mass="54041" checksum="1ACF4BB794D1B9CC" modified="2016-07-06" version="1">MSSDRLNLKNKIWDICGFLRSDGMHIGTYVEQLTILLFLKMMDEREGRFAGEKIKIPKKCRWSTLKKKDGEELLKHYNRVVLPTLSEQKGIIGEIFARVTSHFRTPVNLKEAIEEIDEVEWSKMDADVKGTAYESLLQRYAEEAKGAGQYFTPRPVEKAVVKVIDPDPDDKIHDPAVGTGGFLIHAYEHILKKTHEGADLTRKQRKNLMTENLSGRELVPETRRLGLMNLALHELQPKHFEIGDSLAPGPHTEERYDIVLTNPPYGGNQKKALARQDLPVRTKSPELNFLQHNMNILKIGGECGMVVPDGVLFQSGAAKRIRKMLFQDFNLHTILILPIGAFHPYTNVTTNVIFFKKGEPTEEVWFYDLRTGIENIKKTNPLTSGLFQDFVDNYQTRQKSERYFKVSIKEIEDNYYSLDYKKYREFEGEAEEYPEPEELLTELLSLQDTIAENVESILEEIRSEEGSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE37</accession>
    <name>A0A133VE37_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04710">
        <property type="protein sequence ID" value="KXB04710"/>
        <property type="gene ID" value="AKJ48_01630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="248" mass="28914" checksum="096146BE007AAD80" modified="2016-07-06" version="1">MKEVGPTWKEVVRDALEALGGKGHLSKINERIKGHEKAQTRTWKATIRRTLQQYSIFYQEEPGSGIWFLKGEEPIREFDPEEHPHPGHSDVMGMLLELGRIYDFETTVSPYERKEEFLERTLEDLATLEEVPSFSGYPEVLENARGVDVMWFGGETDRWNPRYAFEVEHTTKFTKGLARLNDLYGAGIRIKPFVIVPEDKLDKAKKELSRDTFKNIHKICRIQTYRPLINLYTLAQKHRSLKTEFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE46</accession>
    <name>A0A133VE46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04720">
        <property type="protein sequence ID" value="KXB04720"/>
        <property type="gene ID" value="AKJ48_01680"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.164"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="107" mass="12311" checksum="A2D014F3264E47FF" modified="2016-07-06" version="1" fragment="single">TSLEGWKQDPIGKIGGVGLTTYQYLRMMGGVDTAMPDNIVKRVIEEILDKAEVKMPTNKDLEFIKTIDQIATISGYRPIEICWMTWLVQSEGDKIRMEKYRDTLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE81</accession>
    <name>A0A133VE81_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_01575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04741">
        <property type="protein sequence ID" value="KXB04741"/>
        <property type="gene ID" value="AKJ48_01575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="303" mass="31890" checksum="EEE4CC28F9268410" modified="2016-07-06" version="1">MSWGQVGSLLGTSLTAMTPLVLAAVGESLNEKAGTINIGLEGIFLITALMGVFGAELVGNWMGGLLFGVGVGALIGFMFAVICVYWRGDQIIAGLGLIMFGSGMVPFWLMAIWGQAGQYTPFGEELFVPQISTPLGSLSLLFFAAIGIAILAHFILHRTLIGVKIRAAGEKPESADVAGISVNQLRLVVCVIGAALAGLGGAFMSLSWVHTVTKEMVAGYGFIALACVVFAGLEPLETLIPAFLFGFGRALTPWANINPAVMNLFPGASYFIKMAPFILVLVAIAIVGRRLFPSAMGEPYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE83</accession>
    <name>A0A133VE83_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04763">
        <property type="protein sequence ID" value="KXB04763"/>
        <property type="gene ID" value="AKJ48_01525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="77" mass="8976" checksum="5E857ECA35472B0A" modified="2016-07-06" version="1">MSKKSNSSFQKVIDSISERLDQIDARLKALENPGNPSSKAKEHRKKNPSPSKKDVNHNYLRKTINDAKRRYEREHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE85</accession>
    <name>A0A133VE85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04714">
        <property type="protein sequence ID" value="KXB04714"/>
        <property type="gene ID" value="AKJ48_01650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="252" mass="29417" checksum="EFAF2AD78F05E5C0" modified="2016-07-06" version="1">MEEEYKEFLSDLKEVKTALKYLGMSYYKRRIPKRLRKLRGSWKTLKDKSKSQRSKKLSEVIETLDQYLKVVFDEEKSSGERIRTIEKIRDERFDIDIKSETRKAEEKRAEIKRLRGILGGDFETELNDLEIVYGESALCTAFLLRRMLEKALYFSFVRNGKLDRIESGQSGKKFIGLKKMIGKAQSEVAKDGSPFLNNKTAGNLMRIKFLGDYAAHNFLSEVKMDDIDRNFTYLCKALEELSRCFKQLTLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEA1</accession>
    <name>A0A133VEA1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04734">
        <property type="protein sequence ID" value="KXB04734"/>
        <property type="gene ID" value="AKJ48_01570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="117" mass="12908" checksum="FF18AE777597F1D2" modified="2016-07-06" version="1">MGAYISKLHDGLTEYVSGTAGVKCVSLVADEFGSKSRAGEELGVSHAAVIDWLDSEGSHPSNARLRQIIDLALKMREEETFTELEKDLARHRSSLGENQKRSPVAKLIPIEKFLKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEA4</accession>
    <name>A0A133VEA4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04783">
        <property type="protein sequence ID" value="KXB04783"/>
        <property type="gene ID" value="AKJ48_01445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007368">
        <property type="entry name" value="DUF434"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041652">
        <property type="entry name" value="DUF5616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04256">
        <property type="entry name" value="DUF434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18481">
        <property type="entry name" value="DUF5616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF434" evidence="1">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5616" evidence="2">
        <location>
            <begin position="66"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="217" mass="24390" checksum="4B45CBC101A137B2" modified="2016-07-06" version="1">MLSPEVRKSIKNLRYLLNQGYPRSSAVEFVSNHYRLELDQRHLLARCVFSKEEATDHQDRGIDVGEVRNRRLGVDGYNVLISVESILGGEQVVKCDDGFIRDLQAIFGKYKMSDVTEKAIDEILNVVDEANPKEVAFFYDKQVSRSGELAGMTRGKLEGRALNGDAKTTVGTDADVRDFEVVASSDRAIIKKSDRVWDVSAEILKHKEANLLDLTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEC1</accession>
    <name>A0A133VEC1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04800">
        <property type="protein sequence ID" value="KXB04800"/>
        <property type="gene ID" value="AKJ48_01335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="78" mass="8890" checksum="05F37E9E033C0737" modified="2016-07-06" version="1">MKVTSKGQLTVPAEIRRDLGIDKDDYLYVTEAGDLILMKRIGVDPKEILNIFQRAAKDIGFTRKELDQAIQEIQQAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEC6</accession>
    <name>A0A133VEC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04802">
        <property type="protein sequence ID" value="KXB04802"/>
        <property type="gene ID" value="AKJ48_01345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="103" mass="12136" checksum="053EA110355CC3B3" modified="2016-07-06" version="1">MFDEFRAYYDSLEYRFRVGEGELEDVIGKLRSYGFEVNLVEEDEISEYTVIIDKFKKHGDLLRNAVDVVELGDEKALVMKDKVAVEEALERGRKPDEEWLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEC7</accession>
    <name>A0A133VEC7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04781">
        <property type="protein sequence ID" value="KXB04781"/>
        <property type="gene ID" value="AKJ48_01435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="172" mass="19517" checksum="FADAFAEAAE052DD9" modified="2016-07-06" version="1">MIYLDIETSAMEADQGMIIAIGLLAGEEVEVKPAVTREEEREALEWLNSKVGVETIVTWYGSEFDIPFLLTRAAFLNIDSQPLIEAPKLDLFKVCKGTFRLSSYSLRSVADFFGIHEKDRFTGKDVPTLFKLVEDGDEEAQKLIIEHCESDLQLLKRVHEWVKPYIESFGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEC8</accession>
    <name>A0A133VEC8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AKJ48_01460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04785">
        <property type="protein sequence ID" value="KXB04785"/>
        <property type="gene ID" value="AKJ48_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="165"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB04785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="378" mass="44343" checksum="C2E89969EDB84126" modified="2016-07-06" version="1">MKYTYKFRLYPTQKQEAKLGETLELCRQTYNHFLSQINESEEIPKRTKLQSQLPKMKTQKPSLDHVHSKVLQMVVYQLYSNLRSLSELKKNGRKVGRLRYKSRGWFKTFTYNQSGFKIIETNNRLDKLHLSKIGDISIRIHRKIKGEIKQITVKHSHSGKWFACICVERQPQREKPIESAVGIDVGITHFATDSDGRQIENPHNLERSLKRLRREQQKLSRKRKGSENYKKQRRKVAKLHEKIKDRRNDFLHKLSRHYVDNYDLIVVENLNVKGMIRNKNLSRYIYEASWGKFVRYLSYKAESAGKVVVKIDPKGTSQEYKHGKLDRDYNASLNILERGMKEVGMGWAESTLVETEPLLHATSQDVITGQVQSLKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEE8</accession>
    <name>A0A133VEE8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="14" type="ORF">AKJ48_01455</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04784">
        <property type="protein sequence ID" value="KXB04784"/>
        <property type="gene ID" value="AKJ48_01455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.116"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="57"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB04784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="912" mass="102073" checksum="64C3792C8A42B505" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEG2</accession>
    <name>A0A133VEG2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <ecNumber evidence="3">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AKJ48_01310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04829">
        <property type="protein sequence ID" value="KXB04829"/>
        <property type="gene ID" value="AKJ48_01310"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.912"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXB04829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="652" mass="70767" checksum="64B9158A7843F28E" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEH1</accession>
    <name>A0A133VEH1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">radA</name>
        <name evidence="9" type="ORF">AKJ48_01225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04853">
        <property type="protein sequence ID" value="KXB04853"/>
        <property type="gene ID" value="AKJ48_01225"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.855"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01123">
        <property type="entry name" value="Rad51_DMC1_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033925">
        <property type="entry name" value="Rad51_DMC1_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="84"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="8">
        <location>
            <begin position="260"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="319" mass="34523" checksum="DE86C5F95B8F0AC2" modified="2016-07-06" version="1">MGEDYSRKKMKRLEDLPGVGPATAEKFSESGFDTLESVATATTHELAGAANIGTRTAAKVIRSAREAADMGYEKATDLMERRKLVGRISTGSESLDEMLGGGVETQAITEFFGEFGTGKTQLAHQLSANVQLPPEEGGLEGGVVYIDTENTFRPERISQMAEAVGLDPKGALEKIFVARASTTDHQMLLAEKAAEMARDDGVKLLVVDALMSIFRTEYVGRGALAERQQKLGRHLATLHKLAEEHNLAVLVTNHVMSNPGVFFGDPTKPIGGHVLGHATTGRVYIRKSKKNTRKAKLVDHPSQPPNTVKFKITGEGIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEH2</accession>
    <name>A0A133VEH2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04804">
        <property type="protein sequence ID" value="KXB04804"/>
        <property type="gene ID" value="AKJ48_01355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="95" mass="11273" checksum="E3B0897BCED66532" modified="2016-07-06" version="1">MYERSFPRQEPKIIVEYRIVGNEKIKDVNTLIVEWEERLRGGERSLISGKLWIDEETEHFLKGERSFHDESGGMLETEPLGKSRLENWRVKGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEH8</accession>
    <name>A0A133VEH8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04831">
        <property type="protein sequence ID" value="KXB04831"/>
        <property type="gene ID" value="AKJ48_01320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.915"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="59"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="463" mass="51207" checksum="DE154CF8EA84183D" modified="2016-07-06" version="1">MTDIALTNGTVITMNQRREVIYDGGVAIEGNKIAEVGKTSEIKEKTSIDREIDCQGRLILPGLIDTHVHLGQALIRACADDLPLVPWLNERVLPLQGIGYQEGDGKLSAQLCTLEMIKSGTTTFVEALLHWKYIDEMTQAVAESGMRGAVSKSLMNLPGYADQPEAIPECMREDGEETLKQTEKMIKKWHGEENNKIHIWYGPRTPGGATVEFYRECAEQADKHDTGITIHLGEVKDDIQYMKNEFDMTPMEFMEHCNLVGENVIYAHGVWIPEEDFKLLKEHECTVSHNPASNLKLGSGIAPIPEMLDAGVNVGLGCDGGPSNDNYDLIRDMKLAALIHKGRLLDPTVMPAETVLEMATVNGAKPTLWGGDIGSLEPGTLADLIVVNLNKTHSAPVRNPISNLIYAGHEGNVETSIIDGEIVMENREVKTLDEKKILEEVIELAPELDQRLDLDIDTRWPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEI2</accession>
    <name>A0A133VEI2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04807">
        <property type="protein sequence ID" value="KXB04807"/>
        <property type="gene ID" value="AKJ48_01370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="60" mass="7219" checksum="6AC576C51B7D8BD7" modified="2016-07-06" version="1">MRISRRAVKALRESSDREEIERARQVPRKYPQTYLRVTGGWAEEKYEELKGKSKLARRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEK1</accession>
    <name>A0A133VEK1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KaiC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04855">
        <property type="protein sequence ID" value="KXB04855"/>
        <property type="gene ID" value="AKJ48_01240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="194" mass="21831" checksum="8C4E549EBC94CAA4" modified="2016-07-06" version="1">MVFGEPGVFISLEREPDALREDARHFGWNLKPFENQGNLELMGGPLDRVVEFRRKVGASGEDLIGEIIQVVQGMGAERLALDGLTQFSTMFPDTQAFRSGLVRLQRELNELTCTSILTSEVEEGKGGLSRLGVEEYVADGVITLHYERSKLFRSRALEVRKMRGTDHSNHLSFFEISDEGIRIRRGKDQDSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEN0</accession>
    <name>A0A133VEN0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04867">
        <property type="protein sequence ID" value="KXB04867"/>
        <property type="gene ID" value="AKJ48_01065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="98" mass="11146" checksum="3E9BF39EAB36E9F6" modified="2016-07-06" version="1">MKTVEIEKGEFSREELSLLESLDAGNERARGAISTILHESLGVSLKDVRVEDQVIVRVFPHRKYAILNPADVHSIIKMGIQPYLQEQEPPKTSLRHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEN5</accession>
    <name>A0A133VEN5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH asnC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_00985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04895">
        <property type="protein sequence ID" value="KXB04895"/>
        <property type="gene ID" value="AKJ48_00985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="165" mass="19215" checksum="21EB247345FDDA23" modified="2016-07-06" version="1">MEVNKMLRGSVKELDRKIIIQLIRDADQPIVDIAKKVGASRQTVSKKLKKFRKSGMIESHMIRLNPEMFGLDTRAYVFLREVPQDDVRARNEKVINKFSQVYSFRRLFGRYSAILEVLTKDREELTSIVKEIHGLEGVRETETFIVHSTVKDEPKDPFLNILEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEP3</accession>
    <name>A0A133VEP3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04920">
        <property type="protein sequence ID" value="KXB04920"/>
        <property type="gene ID" value="AKJ48_00895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.628"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RMMBL" evidence="2">
        <location>
            <begin position="463"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="518" mass="59497" checksum="3B8A029C2FFE8C0C" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ9</accession>
    <name>A0A133VEQ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_00900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04921">
        <property type="protein sequence ID" value="KXB04921"/>
        <property type="gene ID" value="AKJ48_00900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="63" mass="7166" checksum="0DC0BF55DA9FA62C" modified="2016-07-06" version="1">MEGTVKFFNERKNYGFISPDEGDEDLFVHRSDVEAGSLNEGDRVEFETETTEKGPRAVNVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VER2</accession>
    <name>A0A133VER2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatD</name>
        <name evidence="13" type="ORF">AKJ48_01000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 8"/>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04907">
        <property type="protein sequence ID" value="KXB04907"/>
        <property type="gene ID" value="AKJ48_01000"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.708"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="SSF141300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatD_N" evidence="12">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="11">
        <location>
            <begin position="305"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB04907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="443" mass="48737" checksum="91EA832992EBC84C" modified="2016-07-06" version="1">MQGYRGRALELLKSISAEVGDRIKMEKAERIYEGLLMPRTELGDPEHIVVKLDSGYNLGVKVDKNTKISKIGKGKRPKMGMPPTEFKPDPEKPDITIVGTGGTIASRIDYRTGAVHPAFSTQEIYNAVPELADIANIKTVVASNVLSENMTPELWTKIAETVAEELNQGADGVVVAHGTDTMGYTGAALSFMLKNLTKPVVLVGSQRSSDRPSSDASLNLIGAVTVARSDLAGVYVVMHGSTEDEFCLIHRGTKVRKCHTSRRDAFQTVNEIPIGEVREGEISLFQEVERRSEGKVKVDSKFEEKVALVKTYPNIQSDIIEDLLDQDYKGIVLEGTGLGHTPEFLYSGIEKAIERGVPVVMTSQCLWGRVNMRVYSTGRDLLQLGVIPGEDMLPEAAYVKLMWVLSHAKDLEEVRELMLENIAGEITSRSRPDIFLKPILPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VES5</accession>
    <name>A0A133VES5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04930">
        <property type="protein sequence ID" value="KXB04930"/>
        <property type="gene ID" value="AKJ48_00950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="454" mass="52554" checksum="91DC1917F61B56C3" modified="2016-07-06" version="1">MPHLEEVRRLDRRIRVTVSGILILILFLNTIPLTSAGENKSERDYVTYVTIENYSPGDFTLNITDNNGNDLGSLTRGWIENTYEDVVIENFIDTRQVLDHYEYEPSYTVWSYGTPIRDDTPLDDELHWDLNLSDWEIQDIDRSTRFWLHTYIKKLHRHWYRFLTEEVEPNRFQEFNNGWQRFQKFYNWGSTYIDYESGTQGFYSIPIPYHMNYLVKNGEYKIPVYRGEEYTRWRTTTYQINDWTPENWPQLQTQITLTGINGYDENVHLTVETDNELLNTSLEDQVVHVGSIATTKLTITPDRRLHGSIHQITVTATDQYSREKQATYQLDLQTTSKPPVENQVIDVTVTDKKPDQGSGDGGRDPDLRLGVAGDITGDGGPGVSNPGTDVVERYESVSGNSYRSVDEGMLTHETQTFHVWAKASGYMKDDGYATDYANTYEIANLDFDLEPYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEU0</accession>
    <name>A0A133VEU0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-CoA decarbonylase/synthase complex subunit delta</fullName>
            <shortName evidence="1">ACDS complex subunit delta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Corrinoid/iron-sulfur component small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cdhD</name>
        <name evidence="3" type="ORF">AKJ48_00765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04961">
        <property type="protein sequence ID" value="KXB04961"/>
        <property type="gene ID" value="AKJ48_00765"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.519"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01135">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004486">
        <property type="entry name" value="CO_DH/Ac-CoA_synth_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00381">
        <property type="entry name" value="cdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdhD" evidence="2">
        <location>
            <begin position="66"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="388" mass="42951" checksum="96C8F3F1B57A3733" modified="2016-07-06" version="1">MKTLDSIELSEGDELVLEGLEIAPEEIQIKIPSRAIPRVMPPAIEEELEIEKFEPILKEWPEQIQEVVMGATRADGGTRRETVALGGEKYMPFSPDGKNPNRPIATFDIFDSEISLPKVISKHYDGVMGDPGEWAKKSVKEYGAEMVTIHLTSTDPKGADTSPKEAAKSVEEVLEAVDVPIAIGGSGNPEKDPEVLVAAAEAAEGERCLLSSATLDLDWKPIVDAAMEFNHNILAWATIDINLQKELNRKLLNYGVDRDRLVMDPTTAVLGYGIEYSLSVMQRIRLAGLGGDKELNFPISSGVTNAWGAREAWMPASLPQEKYGEDWGPREYRGPLWEVFTGISMLLGGSDLLMVLHPKSVVVLREIINRMFEEKEESVPREDWITIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEU3</accession>
    <name>A0A133VEU3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formylmethanofuran--tetrahydromethanopterin formyltransferase</fullName>
            <shortName evidence="3">Ftr</shortName>
            <ecNumber evidence="3">2.3.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">H4MPT formyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ftr</name>
        <name evidence="6" type="ORF">AKJ48_00805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5,6,7,8-tetrahydromethanopterin + H(+) + N-formylmethanofuran = methanofuran + N(5)-formyl-5,6,7,8-tetrahydromethanopterin</text>
            <dbReference type="Rhea" id="RHEA:18061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57727"/>
            <dbReference type="ChEBI" id="CHEBI:58018"/>
            <dbReference type="ChEBI" id="CHEBI:58103"/>
            <dbReference type="ChEBI" id="CHEBI:58151"/>
            <dbReference type="EC" id="2.3.1.101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the FTR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.101" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04950">
        <property type="protein sequence ID" value="KXB04950"/>
        <property type="gene ID" value="AKJ48_00805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.527"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030270">
        <property type="term" value="F:formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.520">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00579">
        <property type="entry name" value="FTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014053">
        <property type="entry name" value="ForMFR_H4MPT_ForTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002770">
        <property type="entry name" value="ForMFR_H4MPT_ForTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023447">
        <property type="entry name" value="ForMFR_H4MPT_ForTrfase_fd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022667">
        <property type="entry name" value="ForMFR_H4MPT_ForTrfase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01913">
        <property type="entry name" value="FTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02741">
        <property type="entry name" value="FTR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006414">
        <property type="entry name" value="Ftr_formyl_trnsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55112">
        <property type="entry name" value="SSF55112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03119">
        <property type="entry name" value="one_C_fhcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="FTR_C" evidence="5">
        <location>
            <begin position="152"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="303" mass="32585" checksum="3D0848C2AE058975" modified="2016-07-06" version="1">MRINGVEIDDTFAEAFDMMASRILITAENERWALEAAREASGFATSVIECGIEAGIESKADPAETPDGRPGVNIMGTAMSKDGLRKQLRIRVGQCVMTSPTAACFNNLDEGEIVSIGKDLRYFGDGYQIPKRVSGDFSKDDKRLWRVPVMEGEFVVEEEFRIKEGAIGGGNFLVLGENTDSTLRASEKAVEAIKKVKGTITPFPGGIVRSGSKTTSKYSFLRASTNTAYCPTVKSIVESKISAGVNSVLEIVINGLSEAQVEKAMKVGIEAACTVGGIKMISAGNYGGTLGQHFFHLHDILEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEV0</accession>
    <name>A0A133VEV0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04979">
        <property type="protein sequence ID" value="KXB04979"/>
        <property type="gene ID" value="AKJ48_00590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="428" mass="47053" checksum="7BDF6140DE5F45DF" modified="2016-07-06" version="1">MGLRSFLGKVEKKGELTRIDQELSPKFEVSRKLRELDGGPATIFENIKGRKMKVAGNICGTRERIAIALGVERDQLIPRLRDALANPSKPGEASEAPVQEVVEEEVSLKSLPILKYFEEDGGPYITSSILAAKDSNGNRNLSFHRMQVIGENRLAVRLVPRDLHQIFSDAEERGEDLEVAAMLGVHPAVSLAAATSSSYEFDEYEMAGALLDDLKLAECNSVDLEIPARGEIILEGRLLAGERASEGPFADITGTYDAVRDQPVFEVDCLTMREDAFYQAILPGGSEHRLLMGMPREPLIFEEVGKNVKVNNVILTPGGCGWLHGVISISKEKDEDGKKAIEAAFKAHPSMKHVVVVDDDVNIYDSREVEWAIATRARADRDVMIKSNVKGSSLDPTADSETRIGSKMGIDATIDLKEPEKFKRAQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEV2</accession>
    <name>A0A133VEV2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4Fe-4S domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_00770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04962">
        <property type="protein sequence ID" value="KXB04962"/>
        <property type="gene ID" value="AKJ48_00770"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.520"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046356">
        <property type="term" value="P:acetyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016218">
        <property type="entry name" value="AcylCoA_decarb/synth_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000376">
        <property type="entry name" value="AcCoA_decarb_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methoxybenzimidazolylcob(I)amide binding" evidence="5">
        <location>
            <begin position="380"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>5-methoxybenzimidazolylcob(I)amide</name>
            <dbReference type="ChEBI" id="CHEBI:157765"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000376-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000376-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="458" mass="50690" checksum="1CBDC9D9A98505E2" modified="2016-07-06" version="1">MDVYRLLPGDNCGGCGTKTCMGFATDLLERRKEVEDCSLMLEPEHADDLKKLVEYLTPPVRPVTIGERRHAFQIGGEEVMYRHEHRWYNPTAMIIDVDDRMSEDELLKRIEWISSYSRIKIGEELSFDSIAVRSKSGEPDTFSNVVKLVSENTEYPLVLCSYYPEVLESGLKTLGGGSPLLYAATIDNWQEVTGLAMKYGCPVTISSSDLDEMVEISSRALAQGVKDDQIVLDPGTNPLDLKGTRARIVELRRAAIEGEFEPLRFPILGVPATAWVAEKDEDKAAFLEGAIGCMLMNTFVDAMIFHSTEIWSLMPALVLRQDIYQDPRNPASVDSKLMEVGNPDENSPILITGNFALTYYTVEGDCEGIDCYIFPVDTDGTSVTSSVAGDLMTAEKIVDAIEEHNFEEKVAHKTLVLPGDAAVLSGQIEVDSGWNVLVGPKDSASIKDFLAENWPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEW4</accession>
    <name>A0A133VEW4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl21e</name>
        <name evidence="5" type="ORF">AKJ48_00645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04988">
        <property type="protein sequence ID" value="KXB04988"/>
        <property type="gene ID" value="AKJ48_00645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.394"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="97" mass="10913" checksum="8010FD41D4909E70" modified="2016-07-06" version="1">MGKSKGKRSKTRKKLRKKVRDRGKLSAQRVIQDFQPGSKVGISIDPSVASGQPHPKFHGKTGRVKERQGRSYVVEIRDGNDIKKVISRPEHLKLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX0</accession>
    <name>A0A133VEX0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(5-formylfuran-3-yl)methyl phosphate synthase</fullName>
            <ecNumber evidence="3">4.2.3.153</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_00830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 D-glyceraldehyde 3-phosphate = 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43536"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:83407"/>
            <dbReference type="EC" id="4.2.3.153"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.153" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04954">
        <property type="protein sequence ID" value="KXB04954"/>
        <property type="gene ID" value="AKJ48_00830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.532"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007565">
        <property type="entry name" value="4HFCP_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04476">
        <property type="entry name" value="4HFCP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015957">
        <property type="entry name" value="UCP015957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015957-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="237" mass="24965" checksum="7D3E1DE4CC58433D" modified="2016-07-06" version="1">MTLFLVSPISSSEALAAYRGGADIVDVKNPEEGALGASFPWIITEVRQALPEDLPLSASIGDAPDLPGTVTLAALGALNAGANIIKVGLKGPSEKDRAINLMQNVVRAIKKVSDSAEIVACGYGDYQRAGAIKPLLIPEIAHESGADTAMLDTAIKDGKPLTHFLSINKLSEFIEKTHSLNLQAALAGSLGQKEISELKFLKPDVIGVRSAVCTNGDRKQGKITEAAVREVKKVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX8</accession>
    <name>A0A133VEX8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04996">
        <property type="protein sequence ID" value="KXB04996"/>
        <property type="gene ID" value="AKJ48_00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="202" mass="22066" checksum="761BC13CDAE8CAF5" modified="2016-07-06" version="1">MVWIDIARISLAGAILGLIIGKILVEKPRYLIILHPRYWISSAKSASRKRWIRIISIGVIFAGLITIVGGVVSELVTSYWGPAMAEENIFTQIAGVSIILLYASIIILPIFEEWIFRGILLEEIARWKNSRWWGLILSSFVFALFHLSNPGTLPVAAIPLVIGGLILGGCYLVGGLAAAVLAHILYNVFPSILFLLSGLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEZ7</accession>
    <name>A0A133VEZ7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04997">
        <property type="protein sequence ID" value="KXB04997"/>
        <property type="gene ID" value="AKJ48_00700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="88" mass="10247" checksum="6CAF249F118E3EE1" modified="2016-07-06" version="1">MGVHQDIRWLKNNKDRADLFVLVAKRGPARVRELREFLGSDDWWPVKVHIKDMVDRALIEETEDGFKTTDSGEKVFESLKAVYDIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF04</accession>
    <name>A0A133VF04_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_00455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05026">
        <property type="protein sequence ID" value="KXB05026"/>
        <property type="gene ID" value="AKJ48_00455"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.234"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="321"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB05026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="424" mass="47735" checksum="E49EE386791B71CF" modified="2016-07-06" version="1">MKKESGGLFEKLLETQQIFKNREYLRPTYIPDNLPHREEQIDQLARIWVAPLRGETPSNVFVYGKAGTGKTATVKYLMNELEKTGDEVSRKIEVIHLNCEVVNTKYRILATLANELRGKIQEKDPDAEDLPDQVPMTGWPTDQVYSVLLEILELEEQIVIILLDEIDKLISKGADDVLYVLTRINSDLANTKTAVVGISNDLNFVPQLDPRVVSSLGEEEVLFPPYNAPQIEDILKKRAEMSFEEGVLDDAVIRLCAAHAARGHGDARQALDLLRNAGELAEQERATKVTTKHVTKAFHKVERDKMEEAIRTLPEQSKLVLLSALLLQERKARKIGTGDVYDVYSALCRQNGLEVLTRRRVSGLISELDMMGVLNARVISKGRYGRTKEIELNVESIQARAAIEDEMYVKDLNSITSSKQEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF29</accession>
    <name>A0A133VF29_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase II large subunit</fullName>
            <shortName evidence="11">Pol II</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exodeoxyribonuclease large subunit</fullName>
            <ecNumber evidence="11">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polC</name>
        <name evidence="14" type="ORF">AKJ48_00470</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EC" id="3.1.11.1" evidence="11"/>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05027">
        <property type="protein sequence ID" value="KXB05027"/>
        <property type="gene ID" value="AKJ48_00470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.237"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008852">
        <property type="term" value="F:exodeoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000738">
        <property type="term" value="P:DNA catabolic process, exonucleolytic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="PTHR42210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016275">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolC_DP2" evidence="13">
        <location>
            <begin position="3"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB05027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127174" checksum="FD1C17484FD0E239" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF32</accession>
    <name>A0A133VF32_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05045">
        <property type="protein sequence ID" value="KXB05045"/>
        <property type="gene ID" value="AKJ48_00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="254" mass="27169" checksum="68DCF06D93FBE533" modified="2016-07-06" version="1">MDGVIYVEDSPIKGAKETIEKLRSQGRKLVFTTNNSTKTRSGYVKKLSDLGLKVNKDDIITSAYATAIYLRKKSNENGKVFVVGEEGLKSELREAGFEILSERDAENADFVIAGMDRNLNYEKIAAGLRALLAGAEFIASNPDPTYPTETGLAPGAGASIGALSGASGVEPSQIVGKPSRYMVDFALEKTDTQPEQAAIIGDRLDLDIKVGKKVGLTTILVLTGVDSASDVKKVKGSPDAPDFVLKSIRELIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF36</accession>
    <name>A0A133VF36_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MCM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05024">
        <property type="protein sequence ID" value="KXB05024"/>
        <property type="gene ID" value="AKJ48_00445"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.232"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="2">
        <location>
            <begin position="56"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="456" mass="51260" checksum="58E8B997CEA2CF73" modified="2016-07-06" version="1" fragment="single">GTLRAFQEKKRNKKKTTFRKILNVNHIEVQQEGVEEAELSPEDEEEIERLAEEHRIDNMIIDSIAPSIFGYEKIKEAIALQLFGCRAVELTDGSRIRGDSHVLLTGDPGTAKSQLLKWVAQVVPRGIYSSGKKATGAGLTAAAVRDEIGGGWTLEAGALAIADGGLAGIDEFDKMDSEESGAILESMEQQTISVAKAGIVATLNTRTAILAAANPKLGRFDEFENIARQIDIPILILSRFDLIFILRDQPTEERDRSLANHMLKLHSHPEDVVKPKLDAETLRKIIIYARKHVDPKLSNEKVLEKLEDFFVRWRKVAEREAIPITARQLEALVRLSKASARMRLSDEVELEDAERAINLVEHSLKQVGIDSETGRVDIDTIMTGHSRTQRDKFRKIMEIISRLEEEYEGAAPIRVLKEEAATEGISRDFVDETIRREKEKGRLYEPKQDFIARAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF83</accession>
    <name>A0A133VF83_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05106">
        <property type="protein sequence ID" value="KXB05106"/>
        <property type="gene ID" value="AKJ48_00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="98" mass="11475" checksum="4EE0D19445510097" modified="2016-07-06" version="1">MNSTVTTRVDEKTKKELERISKVEHLDRSAIVRRLLEEAIRDYKLSEALKKYQRGEASLGKAAEHAGVSLRRILKEMRERDIHFEYSMDSLKEDVRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA6</accession>
    <name>A0A133VFA6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_00215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05121">
        <property type="protein sequence ID" value="KXB05121"/>
        <property type="gene ID" value="AKJ48_00215"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.38"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="4">
        <location>
            <begin position="390"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="3">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB05121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="712" mass="82217" checksum="383342540F16C6C5" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA8</accession>
    <name>A0A133VFA8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05107">
        <property type="protein sequence ID" value="KXB05107"/>
        <property type="gene ID" value="AKJ48_00110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="174" mass="20041" checksum="584E07B658C412B9" modified="2016-07-06" version="1">MSEVVSDSTVLIFLAKLNKLPLLKMIYPKVLIPEKVHDEVVGKGRRKGERNAIIVRNAIKEGWIEVRETETREDVNEFKLGRGESEALSLSKNLNHEEILVDDESARDAARFLGVKPRGTLFFLAEGLRKSKIDFDEYLKSLEKLIEIGFYMREEIYLEAVRMGRKIAAQKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB2</accession>
    <name>A0A133VFB2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_00165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05115">
        <property type="protein sequence ID" value="KXB05115"/>
        <property type="gene ID" value="AKJ48_00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB05115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="213" mass="23309" checksum="F83048A8B10D4110" modified="2016-07-06" version="1">MKVGILALGSHHERHGAALPLDTDAQIAEHIAREAAKRASAEFFGVLKSSYELPEINTGEHQSLEELEGEVREAVQEAKDEGFDAIVLVNAHGGNEKLSERLNAIEENLGMKIIFNTIICKLEGPHAGTGELSIGSVIGITDESKLEEHTNVGKHPEVGFAGLQEVREKYLWAEKHAREIEEFGVKIDKFLGEKILQCAIVDVINDVRELGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB3</accession>
    <name>A0A133VFB3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <ecNumber evidence="4">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_00170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05136">
        <property type="protein sequence ID" value="KXB05136"/>
        <property type="gene ID" value="AKJ48_00170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.30"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB05136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="119" mass="12941" checksum="3B49ABC4B618D9F4" modified="2016-07-06" version="1">MLDYAKRHADFLEAEVVEELVVPGAFELPIAAKKLASNENIDAVIALGAVIEGDTQHDEIVMMHASRKLMDLSIESGKPIALGVSGPGETRLQALERVNEYARRAVEAAVKTVKRTSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB5</accession>
    <name>A0A133VFB5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CopG family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05131">
        <property type="protein sequence ID" value="KXB05131"/>
        <property type="gene ID" value="AKJ48_00270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.49"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="71" mass="8287" checksum="F89CF4D82793DF69" modified="2016-07-06" version="1">MAKKKKSKSVSIPPELFKKIEDRIEGTGFDSVSEYVTYVLREVVEEEEEEEFSEEDEEKVKERLRALGYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB9</accession>
    <name>A0A133VFB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05104">
        <property type="protein sequence ID" value="KXB05104"/>
        <property type="gene ID" value="AKJ48_00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="105" mass="12561" checksum="030952B055E4CAAE" modified="2016-07-06" version="1">MPYGVWLSEEAAEDRENLSEEQERKLLWWRDRLKQDVTVGDHIRKSQIPSALREKYGINNLWRLELPEEWRILYTIASRPAGNPVVIILRILSHKHYDRLFGYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V996</accession>
    <name>A0A133V996_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000092">
        <property type="protein sequence ID" value="KXB03023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03023">
        <property type="protein sequence ID" value="KXB03023"/>
        <property type="gene ID" value="AKJ48_04320"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.932"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="87" mass="9865" checksum="B4F9F59EA2CA54D1" modified="2016-07-06" version="1" fragment="single">EDARFVLPNAAKTNIVMTMNARSLLHFLELRCCLHAQWEIRELAWKILSQTRKVAPTIFENAGPPCITRGECPEQDSECKLYGAYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9G8</accession>
    <name>A0A133V9G8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidored_q6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000090">
        <property type="protein sequence ID" value="KXB03055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03055">
        <property type="protein sequence ID" value="KXB03055"/>
        <property type="gene ID" value="AKJ48_04270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.920"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="138" mass="15053" checksum="5710B4D782027F09" modified="2016-07-06" version="1">MGLMRFFRKKSPWILTLETAGCNGCIIEIAAALTPRYDVERFGILRKVTPRHADILAVTGAISSQIKDRLVRIYEQMPEPKFVIAVGSCPITSGKLAGCYNVEAPLDDIIPVDAYVPGCPPKPEAIIDGIIKALEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9I0</accession>
    <name>A0A133V9I0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_04225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000087">
        <property type="protein sequence ID" value="KXB03102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03102">
        <property type="protein sequence ID" value="KXB03102"/>
        <property type="gene ID" value="AKJ48_04225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="27"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB03102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="237" mass="27128" checksum="5007A4D8DB724E57" modified="2016-07-06" version="1">MPGYDPLELTEKIKDSVVRELERKYYRFRSTRFYGGIATADCVGCNLNCYYCWSEKPRKHPDKIGNFHPPKGVANKLIKIAREKDFTQVRISGNEPTIGKKHLVEVLGEIQDTGLRFILETNGILIGQDPQYAQELAQFPNLHTRVSLKGCNPQHFHELTGANPQAFDLQLQALENLLEAECECHSTIMRDLATPQQLHDLMKRLGGIDPNLPHSLDFEQLKLYPHVRKRLKKQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9M3</accession>
    <name>A0A133V9M3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000084">
        <property type="protein sequence ID" value="KXB03152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03152">
        <property type="protein sequence ID" value="KXB03152"/>
        <property type="gene ID" value="AKJ48_04175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="549" mass="62866" checksum="6BD07C8791AE25AF" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9P3</accession>
    <name>A0A133V9P3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000084">
        <property type="protein sequence ID" value="KXB03151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03151">
        <property type="protein sequence ID" value="KXB03151"/>
        <property type="gene ID" value="AKJ48_04170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="184" mass="21124" checksum="D1C2292A50EEBD0C" modified="2016-07-06" version="1" fragment="single">KEVYGIEISEKGVKLARENGVKAFRINIDGSKLPFEDNYFDGVFAGEIIEHLYDTDNFVNEVYRTLKPGGIFVMTTPNLAWWVNRVCLLFGFQPYGMNVSSNFSIGHVYEPKNEFSSFDHIRFFTLKSLQEFLKLHNFQIINIIGVHIRLSGLPLLTSIVNVIDRLLSFRPSLSNCMLLVLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9T3</accession>
    <name>A0A133V9T3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000080">
        <property type="protein sequence ID" value="KXB03220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03220">
        <property type="protein sequence ID" value="KXB03220"/>
        <property type="gene ID" value="AKJ48_04095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="156" mass="18172" checksum="6A3AA25E63612999" modified="2016-07-06" version="1">MIILKEVPSKIKMMLAEGELAYFCTTDESLKPHVTPMLYLYDVEENKVFLMTTKDSKKVKNLRSNNLISLTVDVRNPENPFLNYGTMIQGTAHVKDLTENMEIVDRFTQKYPDFVGGRKLKGKLPPARPDTLIEVIPKLMVYWRGTRFTRWKDEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9U6</accession>
    <name>A0A133V9U6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000080">
        <property type="protein sequence ID" value="KXB03222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03222">
        <property type="protein sequence ID" value="KXB03222"/>
        <property type="gene ID" value="AKJ48_04105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="195" mass="22834" checksum="6E8F66F8F85BF441" modified="2016-07-06" version="1" fragment="single">SRGKKVLKEVLDKDFDGTIGCDGWSSYAAFAINIAPNSNIQRCWSHLLREADDLAEKCEEAVPIAEELHRIYDELIAFVGKDPPPEEREERKEEASRELKQLLSEDYEDEEIEDLMKKIGNGFDYWFTFLTEPRVESTNNRAERALRELVIQRRIMGSIRSERGRRAYETIMTMLATWKQQKLDPYEEMLKAIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9V3</accession>
    <name>A0A133V9V3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000082">
        <property type="protein sequence ID" value="KXB03185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03185">
        <property type="protein sequence ID" value="KXB03185"/>
        <property type="gene ID" value="AKJ48_04135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="400" mass="43152" checksum="060C2C1CEFDB04F8" modified="2016-07-06" version="1">MPENYDVVVAGGGPAGLAAARVAASEGGKVLLLELQAQIGGQTQSAAWIPSELIDDTLEGSVIDSVQSVVLRSPHRELEVEGDFGVIVNRGSFDKLLAAEAAKEGVEIWVGSPVRGILEDEKGVYGVRAEAGGWSESIECGVVIDATGARGQWSSLFLREIQEGDWDEERMTRSNEYLMANARSSGEVELYFNSLFAPLGHAWIYPFGQNFVMSGIRGARIHPDAALDEFIGREEPEKLVGSSPIAAFRGQLPLSRLESACENGIMSVGSAAGQVHPLSGHGVGYALEAGETAGETAVDAITEGDTSRDKLREYEQRCQSKFGRELQAGEILQEGLQTAPDRKMDALLEILDSHPDLQEEFVNVFLSQDLEASLGSLLKNKEVEQIFGQENTRKILALYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9W6</accession>
    <name>A0A133V9W6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000079">
        <property type="protein sequence ID" value="KXB03236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03236">
        <property type="protein sequence ID" value="KXB03236"/>
        <property type="gene ID" value="AKJ48_04075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="106" mass="11942" checksum="1A98DD5805B48C77" modified="2016-07-06" version="1" fragment="single">WGLYSMDSELTEHISREGRVRLVNLILDNGWTVSELARRLGVSRQAVYLWLDSQETHPNNSHLGDLVNLAIEVDDQSASKILLGEVNQFRLAVDEKILGQISGKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAA0</accession>
    <name>A0A133VAA0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0248 protein AKJ48_03970</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0248 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000073">
        <property type="protein sequence ID" value="KXB03361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03361">
        <property type="protein sequence ID" value="KXB03361"/>
        <property type="gene ID" value="AKJ48_03970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01245">
        <property type="entry name" value="UPF0248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007547">
        <property type="entry name" value="UPF0248"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316" evidence="2">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="80" mass="9185" checksum="DF1880289C89F446" modified="2016-07-06" version="1">MGPRDILNKLKWHPDFSLKGAKITIIHRGAPDDKRVIKGEDITEIGSGFMHVGTGLEKVEIPYHRVLKVETPEKVIWERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAB7</accession>
    <name>A0A133VAB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000072">
        <property type="protein sequence ID" value="KXB03383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03383">
        <property type="protein sequence ID" value="KXB03383"/>
        <property type="gene ID" value="AKJ48_03930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="90" mass="10489" checksum="682DD94FCFAD6035" modified="2016-07-06" version="1" fragment="single">GFEEDKPQLSRIYKWDARKDALESTGVPSQIKKTIADFAGISGEEVEIEIEKRGAIVEWMREQEIRDIFEVGEVIQEYYRDPEGLLERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAC0</accession>
    <name>A0A133VAC0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_03940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000072">
        <property type="protein sequence ID" value="KXB03384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03384">
        <property type="protein sequence ID" value="KXB03384"/>
        <property type="gene ID" value="AKJ48_03940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="105"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB03384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="314" mass="33206" checksum="779E6FE965C90343" modified="2016-07-06" version="1">MGIVEGSAKLARKILPESFLDKTERSLESTNVALSAEEFLGISLTIAIIAGVGGFLAGFIFLSIIFAIIAAIGGILATFMIIARAVPYYLAQRRAKELEESLPDALRQMASTLRAGVGMNAAMEDVSKSGYGALSQEFDRAVVEIRKGRALEDSLAALAKRSNSKLYERAFRLIVEGIERGAALADVLEAVSKDAREVHTIQRERRAATMQQVLFLIAASVFSAPFIAGLVIAVGGAFSTLGAAGAAGAISQALPSGMKLIVFLFILIQAAICSLAVGVIRYGRMMKGIMFTAPFVVGAAVVFYCAQMVAGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAF6</accession>
    <name>A0A133VAF6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000069">
        <property type="protein sequence ID" value="KXB03448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03448">
        <property type="protein sequence ID" value="KXB03448"/>
        <property type="gene ID" value="AKJ48_03880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="206" mass="23885" checksum="B2C3D8A079B4E73A" modified="2016-07-06" version="1">MGARRHRVSEEEFRAEINYTNFDPLPENGVLIIGDTIATGSTLSRALGEVRDELRRRDYGVKRLVVFSIAAAFRGCTKLLEWEKRFREWWPDFEVHLFAAEALFGLESGTHLRFRKPEEAIVPTNTKKYVTRTYGDYEEAYLPGNICSIFDWGDRNFKPDRHLEDVLKFARTSIEKAEDDKSKEILEELEEGALAELERYKSSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAJ1</accession>
    <name>A0A133VAJ1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000068">
        <property type="protein sequence ID" value="KXB03472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03472">
        <property type="protein sequence ID" value="KXB03472"/>
        <property type="gene ID" value="AKJ48_03860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="161" mass="18392" checksum="2B9F599BCBF526D7" modified="2016-07-06" version="1">MKKRRTIYSFKKEPVEEEKIEKILEAGRWAPSWTNTQPWRFVIVKDDDTKKEISEIFLEVFRKGIRDAAVLIIVFVDPDEDQYHFVEDGAVATQNMALAAESLNLGSTWIGVFDTENEEKVKETLNVSKDLRAISALPIGVPEDVPEKGRKDISSLILKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAJ8</accession>
    <name>A0A133VAJ8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_03835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000067">
        <property type="protein sequence ID" value="KXB03498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03498">
        <property type="protein sequence ID" value="KXB03498"/>
        <property type="gene ID" value="AKJ48_03835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB03498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="141" mass="16447" checksum="13F04EAE1FCF3211" modified="2016-07-06" version="1">MNQKRVERYRGKVERIEVRASDIEEWISDLSELDFEQDKKTRLAIYKAFQELVESIADICAMYAADTGRVVGDDHENIEKAAGRLYESELSNDLKNSNGLRNRIIHEYNGLNHKIAYDSINELLPSLKKFGEEVKRWIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAM6</accession>
    <name>A0A133VAM6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000067">
        <property type="protein sequence ID" value="KXB03493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03493">
        <property type="protein sequence ID" value="KXB03493"/>
        <property type="gene ID" value="AKJ48_03820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="159" mass="17701" checksum="35290EDB812F4D7B" modified="2016-07-06" version="1" fragment="single">MVVCDSAPLIHLSRVNELGLLKDLFGEVNIPPSIYREVVEEARELGKPWVSTIEGAIDDGWLKVTKIRGRKKIKKLAESEKIQIEDAEVLYLAKDLATSLVTSDGWLIKIAKGIGVETLWTTTLVLLAIKEGKMSKRKGKNLLRELITSGLYVKPDVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAU4</accession>
    <name>A0A133VAU4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_03800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000066">
        <property type="protein sequence ID" value="KXB03525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03525">
        <property type="protein sequence ID" value="KXB03525"/>
        <property type="gene ID" value="AKJ48_03800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB03525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="134" mass="15041" checksum="E58DB7C89BE09E57" modified="2016-07-06" version="1" fragment="single">MAGPRPLFIKAHMRRTLELVSEHEPIGRKRLARKLRVGEGSMRTILNRLKDDKLVASTPQGHILTKKGKQEFKRKPRKFLTLDAGDLTVGEVDVATIVRKASEKVKLGIRQRDEAIKAGADGATVLVFSDERFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB08</accession>
    <name>A0A133VB08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000062">
        <property type="protein sequence ID" value="KXB03648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03648">
        <property type="protein sequence ID" value="KXB03648"/>
        <property type="gene ID" value="AKJ48_03710"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.732"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="181"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB03648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="446" mass="49841" checksum="026A689FC1C7385A" modified="2016-07-06" version="1">MRSVLISPPAGSAIESRFGSVGIPAGAYLAPILEDEGHKVKIIDSSTMGYNLEDVKQELKEFSPEFVGISSLTTSIYQAYGVAKAAKELEPDCTTVIGGAHATSAAEEVLGECPHIDIAVRGEGEETLRELVSSKNLSSIKGITYREDGEIVENEDRKIIRDLDLLPFPAYHLLPMEKYKVGGIKYATMMTSRGCPFDCIFCSSSEICGKTWRAKSPERVLDQIRLLKEEYGRREIEFLDDTFTLDNERARKICDLLIEGGLDVSWSCSSRVDTIDNSLAEKLKEAGCHTVYMGIESGVQKILDKLKKGITLEQVKKAVRSVKEAGLNTVGSFILGIPGETKKQMEKTVKFAKELGPTFAQFTLFTPYPGTEAYRMAEEKNLLVTRDWSKYTTLDPVIKKANMTAEALKNFLRKAYLSYYLRPSYIWRSIREGRFWTFLKMALGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB32</accession>
    <name>A0A133VB32_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000062">
        <property type="protein sequence ID" value="KXB03649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03649">
        <property type="protein sequence ID" value="KXB03649"/>
        <property type="gene ID" value="AKJ48_03715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="108"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="283" mass="32676" checksum="CAD4F45C736B9205" modified="2016-07-06" version="1">MTRNWREYNGKLVKRGEFYLSPDFLDSWDEELEEMNRGKIGRPYEFPESFVQFAALWYEFFHLPYRQLEGVLRKLGSLFPELKASDYSTLWHRFKDLKIEVPKSNVIIVAVDSTGIKVTNRGEWMRKTHRGERGGWIKVHVAVDVESKEILSIEVTDEKTGDSEVFEDLVEDLDPKDCLGDGGYDSEKVFKILEKKGVGSPGIKIRKNARTGLSPRGQAAKEFQELGHEEWKKKHEYGKRWAVEGFFSAVKRCFGETVRAASPAGMVREVKRKFGLYNLVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB61</accession>
    <name>A0A133VB61_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000062">
        <property type="protein sequence ID" value="KXB03647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03647">
        <property type="protein sequence ID" value="KXB03647"/>
        <property type="gene ID" value="AKJ48_03705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="140"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="447" mass="49813" checksum="34A9C6E6B43E40E1" modified="2016-07-06" version="1" fragment="single">LRENGFDESEVVVVHPDDLEKMVGPETEIVAIGGHDLLGINPPTSEFVELAATGPPYNRVKFLELLESPALRDVNVVVGGKSAWQVADERVMDRLGIDYVHIGEGERSIPEMFSKILNGEEVPRIVEGEEVPVEDIPNLRGWVIYGLVEIMRGCGRGCKFCTPGMQKLRHKPIDHILRDVKTNLEAGAKNIGLHSEDVLRYGTYEIAPNREKVLELFKKVSDLNGVKAMGTSHVALATVYHNPDLVRDVSEIFHTLPEQERIGTQTGIETGSPRLMEKHMRGKALPSSPEKWPEIVDQSLGLLDDNNWTPACTLINGLPGETRDDAAKTLELLDEIKNHTALIVPLNFVSMEGSSLSKENSLRAEGVYPEHWQILGECMEHDAEIARSLKSDKIRGNVLIKWLFEHFSDYLIKGAEKYAEGMKAGNPPKNYSEISEDYTVPEVLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB88</accession>
    <name>A0A133VB88_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_03690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000061">
        <property type="protein sequence ID" value="KXB03690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03690">
        <property type="protein sequence ID" value="KXB03690"/>
        <property type="gene ID" value="AKJ48_03690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.728"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01571">
        <property type="entry name" value="NAPRTase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035809">
        <property type="entry name" value="NAPRTase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_C" evidence="8">
        <location>
            <begin position="121"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB03690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="396" mass="43429" checksum="C8BBEB9392C7A868" modified="2016-07-06" version="1">MKFHVASDEQIKAGETTDVYFSRTQKILKEEDISDRRVVAEVTAGSLPRDWQWAIFCGIDEVAQLFEGYPVNVWTIPEGKAFKPVDYRRRRVPLIVIEGPYGDFCTLETPMLGLTCQASGVATMAARVRRAAADKLLLAFGIRRMHPALAPMLDRAAYIGGCDGVSSLIGAEAIDKEPMGTMPHGLIIAMRDQVKAWKAFDKHMPEDVPRIALVDTYSDEKVEALKAAEALEGKLDGVRLDTPGSRKGSFPELVREIRWELDLRGYEHVDIIVSGGLDEYKIPGLVEAGADSFGVGTSISNAPVLNLAMDIVEVEGEPAAKRGKLGGRKQVWRCPKCMVDMITPIGNEAPKCPECGGKTESLLEPLIEGGELVKELPSPDQIRESVLNQLENLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBA3</accession>
    <name>A0A133VBA3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000060">
        <property type="protein sequence ID" value="KXB03732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03732">
        <property type="protein sequence ID" value="KXB03732"/>
        <property type="gene ID" value="AKJ48_03675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="43"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="423" mass="50179" checksum="572575D9CF2D9074" modified="2016-07-06" version="1">MEREEIIEEMYSQNPWWRSEPVKLPDKAVERNLMPQILEDLKSERVTTIVGLRRVGKTTLLKLIIEELSKELERERICYFSFDLAEQIQPREIVKIYSEEIIRKTLPELEERVYFFFDEIQKVKDWGNQVKSIQDKGYNIKFVATGSSSINITKGIGESLAGRTLVRRLRPFSFPEFLMYRNVDFERGELEEPIYPDNSEKLRILFNEYMEAGGLPELYEEMSLELLKQILDLVFFRDIVNLFPVKRTDVLKGIFRILVENTAQKVNYTKFARDLDTQYRTVKEYLQYLEDSFLIQRSHPYEGRRLKRYRKNPKIYVADHAYTNLWKCEEGLKAETIAFNHLKRIEKPFHLKDPEIDIVLPENKCAIEVKYKPEVRKSDAKPLTKLSNDFKLFLVTKENYGTWNINGRDVQLIPLWLLCTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBE6</accession>
    <name>A0A133VBE6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000059">
        <property type="protein sequence ID" value="KXB03773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03773">
        <property type="protein sequence ID" value="KXB03773"/>
        <property type="gene ID" value="AKJ48_03640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="133" mass="14823" checksum="3F414C90C1EDAED0" modified="2016-07-06" version="1" fragment="single">DLGAQWRGYRSDMTRTFSISPTPKQEKILKISKKAQKAALNVIKADVKAKEVDEAARKVVRKADYEEYYLHGSGHGVGLDIHEPPSLTPDSEDVLKEGVVTTVEPGIYVQGVGGTRFEDMILVTRQGYEFLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBK7</accession>
    <name>A0A133VBK7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pterin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000058">
        <property type="protein sequence ID" value="KXB03829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03829">
        <property type="protein sequence ID" value="KXB03829"/>
        <property type="gene ID" value="AKJ48_03635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="214" mass="23359" checksum="415AE401DF015BDB" modified="2016-07-06" version="1" fragment="single">MVKRKFSGIPLGDEAPAVITGVINIAPETFYKESSVQNPQKAADRAEKMIEDGADIIDLGAMSTAPGVEPISLEEEKQRLLPVLEKVSERIDAPISIDTQRAEVAKIALESGGQMINDVSGFKYDSRMPSVVTDFDCPAVLMAAKQEPGDARKIEEVKQVLQESLDICDREGVDLEKIVIDPGIGFGKGTKWDLHILKNLHELKKLNHPVCVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBN4</accession>
    <name>A0A133VBN4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable aminomethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gcvT</name>
        <name evidence="8" type="ORF">AKJ48_03625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000058">
        <property type="protein sequence ID" value="KXB03827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03827">
        <property type="protein sequence ID" value="KXB03827"/>
        <property type="gene ID" value="AKJ48_03625"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.694"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="6">
        <location>
            <begin position="7"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="7">
        <location>
            <begin position="288"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB03827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="364" mass="40653" checksum="F8D2EE4E8A5C6D5E" modified="2016-07-06" version="1">MKKLQLSSVHKSLGAEMTQFAGWEMPVKYTRIVEEHLAVRNAVGLFDISHMGEISIVGEGALEFLQKVTSKDVSKLGIGMAHYTMVPNEQGGVKDDVVVYHLEEQDYMVVTNAVNATKIYEWFKQHTPSDIQIDDITNDTVLFALQGPRAQAVLQKLTDFELEDLNRFSNSFIKIAGVKALASRSGYTGEDGFELYVFKQLEDSSQGERIWNELLRVGGEEEIKPCGLGARNSLRLEAGLPLYGHELTEEITPLEARLGFTVKFGKGEFIGRKALQEQKEEGVNSWRIGLKMEERGIPREGYKLIHDGKEIGEITSGGFSPVLKTGIAMGYSSVDLDEGNGIMVRIRGEEKRARIVNWPFHKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBP0</accession>
    <name>A0A133VBP0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000057">
        <property type="protein sequence ID" value="KXB03871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03871">
        <property type="protein sequence ID" value="KXB03871"/>
        <property type="gene ID" value="AKJ48_03595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="158" mass="17671" checksum="CC1E5BFB9E8EEED9" modified="2016-07-06" version="1">MRERTVTEKIIAAAKYGQRLYIRRRGSHEHITAYDPASKKVKHLGSIDVKEPSFARNIVRVEQSMEEVREFLEGENIKSRLHSAKERGSALSYAQARSSSTGAGYVGWTPECETTTERYGSAPRSICSSCGKKGVLLFQPGFSTANGNRRAWDDLAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBW1</accession>
    <name>A0A133VBW1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000057">
        <property type="protein sequence ID" value="KXB03874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03874">
        <property type="protein sequence ID" value="KXB03874"/>
        <property type="gene ID" value="AKJ48_03610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025707">
        <property type="entry name" value="DNA_bp_PD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016702">
        <property type="entry name" value="DNA_bp_PD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="142" mass="15943" checksum="47E943526BBC6BF9" modified="2016-07-06" version="1">MTAAELDLGRNFVIRAEHDSDIIQYIIKFAEDNEIEIGTFMAIGALKNAKLGFYNQKEHEYQEMEIASPHEIASCLGNISLKDKKPFVHAHAVLADESGETRAGHLIGGTVFAAEIHLRELKGPKLERKHDDVTDLSLWKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBX1</accession>
    <name>A0A133VBX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000055">
        <property type="protein sequence ID" value="KXB03951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03951">
        <property type="protein sequence ID" value="KXB03951"/>
        <property type="gene ID" value="AKJ48_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="137" mass="16557" checksum="022DDD13754C848B" modified="2016-07-06" version="1">MRVAQPTPDEFDREYFEYRGKGEIRGAHRGDLPKMEALFNRFEWTIKDSIRQVFEKTPYERPFVEMMNEAEENMAKCLVLENPKGRVTGYALLTSRRKPQSWTSWFGQSTEIRHTICWKRYYRKLRERFAPTSHRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC02</accession>
    <name>A0A133VC02_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MgtE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_03520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000054">
        <property type="protein sequence ID" value="KXB03978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03978">
        <property type="protein sequence ID" value="KXB03978"/>
        <property type="gene ID" value="AKJ48_03520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="PTHR16228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="MgtE" evidence="7">
        <location>
            <begin position="48"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB03978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="185" mass="19398" checksum="0C141307AF0AFB5A" modified="2016-07-06" version="1">MADVTARNIVGQALPILLLCVLIEVGAGLVLGGMEENFKLLPGLIVLVPPLLGLRGNISGALASRLGTALHQGVLDPRFLWGPEMRVNVFSSFFLTLLVSASAGILAWLVTLLVGIESVSLFTFLAIAIIAGILSSFILIGLTIGIAFMSYAKGFDPDNVTSPLMASIGDIFTVVCIYISVLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC54</accession>
    <name>A0A133VC54_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000052">
        <property type="protein sequence ID" value="KXB04033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04033">
        <property type="protein sequence ID" value="KXB04033"/>
        <property type="gene ID" value="AKJ48_03435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="146" mass="16036" checksum="97AC8F4098A4CBCD" modified="2016-07-06" version="1" fragment="single">VRELEEKGAYWRRKNAELAEKGPELPYPTSWKGGGAGQMVMDTLYSETLGKGIRFIEDTAATSILTKGGKCVGATAINYASGEFLVIRAKAVILATGHTGYQYTYSTQSREVVGGGIAMAYRCGAELHSLEFQHWHHSDTLYPNSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCU2</accession>
    <name>A0A133VCU2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000046">
        <property type="protein sequence ID" value="KXB04224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04224">
        <property type="protein sequence ID" value="KXB04224"/>
        <property type="gene ID" value="AKJ48_03260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="72" mass="8111" checksum="A8F5B6AB1A7D8B03" modified="2016-07-06" version="1">MLTYTSYLRPLLLVLAPLMIGILARRTKKLDPIFKGIYALVLWAVLPVLVFGSVAIQRPDQMYNLGGQLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCV5</accession>
    <name>A0A133VCV5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_03125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000043">
        <property type="protein sequence ID" value="KXB04286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04286">
        <property type="protein sequence ID" value="KXB04286"/>
        <property type="gene ID" value="AKJ48_03125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.560"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="94" mass="10406" checksum="C59F85F489F7B4F7" modified="2016-07-06" version="1">MVEDPYKNLKITKGAVAKPSTTLVNKTGSWRAFRPVIDHDKCIGCGTCEKFCPDMSVKEVEDGKFEIDLDYCKGCGICAVECPVDAIQMVKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCW2</accession>
    <name>A0A133VCW2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000045">
        <property type="protein sequence ID" value="KXB04270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04270">
        <property type="protein sequence ID" value="KXB04270"/>
        <property type="gene ID" value="AKJ48_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="91" mass="10677" checksum="ED37A33D4BC0D333" modified="2016-07-06" version="1">MNPSFIWRPLTLLIRAFLSDKVRFCPNCGSKEVVRDGHNGRENIPRVQMFRCNSCGRRFSERANTIFYWKHASMGELFIITWIFFGSGSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCX6</accession>
    <name>A0A133VCX6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem I assembly BtpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000041">
        <property type="protein sequence ID" value="KXB04303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04303">
        <property type="protein sequence ID" value="KXB04303"/>
        <property type="gene ID" value="AKJ48_03020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="PTHR21381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="103" mass="11346" checksum="D75346F7B83D8056" modified="2016-07-06" version="1" fragment="single">FPGIDLRTHAIWSEYYLADALIVTGEMTGRPPKIDDVKTVKEATNRPVLMGSGMDKDNVSEFLKYADGAIVGTSLKEDGVTENPVDLGRVKEFMKTVEKIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCY0</accession>
    <name>A0A133VCY0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytidylate kinase</fullName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytidine monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_03105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04302">
        <property type="protein sequence ID" value="KXB04302"/>
        <property type="gene ID" value="AKJ48_03105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="140" mass="16175" checksum="F1A967C90FCB192D" modified="2016-07-06" version="1" fragment="single">QGMTLEEFSKHVEENPEIDEEIDQRTAKEAEKGNVLIDGRLSGWMAKNADVRILLIASLEARVQRITNREDRDLEEVEKETITREESEAKRYKKLYDIDVNDYSVFDIILNTESFNESEMVDILEKAVKIKTGTDQPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCY1</accession>
    <name>A0A133VCY1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000044">
        <property type="protein sequence ID" value="KXB04281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04281">
        <property type="protein sequence ID" value="KXB04281"/>
        <property type="gene ID" value="AKJ48_03195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="67" mass="7514" checksum="7EEAADA57CF1643F" modified="2016-07-06" version="1">MVLVRRIGSQESQKYELSEGARIIDLLEKTEFNTETVVVRQNGKIVPEEEQLEDGDELELIPVVSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCZ6</accession>
    <name>A0A133VCZ6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04326">
        <property type="protein sequence ID" value="KXB04326"/>
        <property type="gene ID" value="AKJ48_02950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="103" mass="11021" checksum="D76B1E43AFD40C9C" modified="2016-07-06" version="1">MKRAAGATSSFTNGIFQADEMQIRSFGERLWIMGVRRSDGGISLNALKGDSGLEFKSSLKLAAEELGPTIVLDTDGHTSYPFGGKAVGGNSPTGESEERRIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD46</accession>
    <name>A0A133VD46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04362">
        <property type="protein sequence ID" value="KXB04362"/>
        <property type="gene ID" value="AKJ48_02830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="97" mass="10970" checksum="35840AAEE52576EE" modified="2016-07-06" version="1">MKDLESEIGKIEEKVERGMGKREGRGSGVRKVSEDVESLLLEKGEPLSIPEIGEYLPHEQKQLLRGVERLEDQLRVERIERGDGLTKWRAGGSRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD51</accession>
    <name>A0A133VD51_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000037">
        <property type="protein sequence ID" value="KXB04351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04351">
        <property type="protein sequence ID" value="KXB04351"/>
        <property type="gene ID" value="AKJ48_02890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="70" mass="7795" checksum="1F10B5F1DA12EDA3" modified="2016-07-06" version="1">MTHSTPWKGIKDLLANEGLSIERFIGGLKMIWMENRRTIDSTERSPSIGGMFEERIIGNCSGSPTQDVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD64</accession>
    <name>A0A133VD64_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04365">
        <property type="protein sequence ID" value="KXB04365"/>
        <property type="gene ID" value="AKJ48_02845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="174" mass="20687" checksum="C86A1D58BFDF1560" modified="2016-07-06" version="1">MSKKKILYGDVDVESLKELRGKIDDPKVRDRITAVIMEVKGYKRGEMADLLSVHRETVRLWIKRFDESGIEGLWDGKRSGRPSKISESEKERLREDLKGSPKEFGYESEVWSTKMVLDHLREEYGVEYHPRYIQRFLRSLGFELKKPRPEHRKASEEEKEKYYQRVEKAKKGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD67</accession>
    <name>A0A133VD67_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="9" type="ORF">AKJ48_02790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04380">
        <property type="protein sequence ID" value="KXB04380"/>
        <property type="gene ID" value="AKJ48_02790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="114" mass="13433" checksum="003898D2731784A2" modified="2016-07-06" version="1">MEELPPQVQHQLTQFQQTQQRAQALATQRRQLEINLRETERALKELENLGEDATLYKSVGRIMAETNSSNAKEELEDRKETLDLRVKTVERQQERINKKMEEMRAKIQDALRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD89</accession>
    <name>A0A133VD89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04364">
        <property type="protein sequence ID" value="KXB04364"/>
        <property type="gene ID" value="AKJ48_02840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="126" mass="14336" checksum="618844ACCCBC782D" modified="2016-07-06" version="1">MTFIDESIFRIEPIVKHGWFLKGSKPSCPVNWSRGKECVFGALNFENGGKLMSKQAKRINSKTFIEFAQLLMRDIGSFAMPPVRILIPERFQVLKGRGRFDNLISVLETLEGPQISAHQTPSKLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD90</accession>
    <name>A0A133VD90_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">AKJ48_02640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000032">
        <property type="protein sequence ID" value="KXB04418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04418">
        <property type="protein sequence ID" value="KXB04418"/>
        <property type="gene ID" value="AKJ48_02640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.426"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="306" mass="33822" checksum="A7B71B6DBD3FABEA" modified="2016-07-06" version="1">MNLHGRDMISLRGLTDEELLHIFDTADEFEPVARGEKHSDVLKGKVVGALFFEPSTRTRLSFESATQRLGGGTLGFAEARTSSVAKGETLADTIRTVEKYCDTIVLRHPKMGAARLAAKMAEIPIINAGDGAGHHPTQTLLDLYTIRKVSGKIEGINLGLVGDLKYGRTVHSLAYAISRFTSRIFLISPPSLKIPREIVGDLSDMGVKVIENSNLDKVLPQLDVLYVTRIQKERFPDPAEYSKVKGTYRIDLETLEEAKSDLQVLHPLPRVDEIAPEVDSSPYGRYFDQVFYGVVVRMALLSLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD94</accession>
    <name>A0A133VD94_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_02755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000034">
        <property type="protein sequence ID" value="KXB04395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04395">
        <property type="protein sequence ID" value="KXB04395"/>
        <property type="gene ID" value="AKJ48_02755"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.453"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="9">
        <location>
            <begin position="394"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="561" mass="60537" checksum="9C798E72BEC93A4A" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDA3</accession>
    <name>A0A133VDA3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTP_synth_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000032">
        <property type="protein sequence ID" value="KXB04422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04422">
        <property type="protein sequence ID" value="KXB04422"/>
        <property type="gene ID" value="AKJ48_02665"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.433"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="96" mass="10532" checksum="6A75718115D02713" modified="2016-07-06" version="1">MTKFLFVTGGVLSGIGKGTVAASIGKSFQFRDLKVDMIKIDPYLNVDPGTLNPIEHGEVFVTDEVWEFEPSKDSSFTTAEVDQDFGILKGLNKFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDB7</accession>
    <name>A0A133VDB7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000034">
        <property type="protein sequence ID" value="KXB04394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04394">
        <property type="protein sequence ID" value="KXB04394"/>
        <property type="gene ID" value="AKJ48_02750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="80" mass="8754" checksum="63A6BE63D2C59BA6" modified="2016-07-06" version="1">MGSRQEEGGRALRYGNFIALGFGLAIAGYACKYIVKFFFPLPQLPDPNSFLIFANIGAVVIVVSLGAEIFVTIRNKLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC8</accession>
    <name>A0A133VDC8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="5">RNA cyclase</shortName>
            <shortName evidence="5">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="5">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rtcA</name>
        <name evidence="9" type="ORF">AKJ48_02590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000031">
        <property type="protein sequence ID" value="KXB04435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04435">
        <property type="protein sequence ID" value="KXB04435"/>
        <property type="gene ID" value="AKJ48_02590"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.417"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="7">
        <location>
            <begin position="8"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="8">
        <location>
            <begin position="181"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="290"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="355" mass="38025" checksum="31C4FB264B478F54" modified="2016-07-06" version="1">MIKIDGSIGEGGGSIVRLSTALATVTQEPVEVYNIRAKRDNPGLRPQHLEGLKALAKLCNGKLEGGEIGSTKITLNPNQVQGKKIGVRIKTAGSIGLVLQSLMIPAPLADSEVKIEFEGGATDTFFAPPIDYLNNVTLPTLRKMGYQGEVEQIRRGHYPKGGGIVRSQIQPLKKLKSLKLTEPGKIKSVQGISHCVKLPGRIAEKQASSAKRILSKAGYDAEIEVETYKKSEDPHLSPGTGIVLWAETENEVILGSSALGKKGKPAEKVGREAAENLVKQLETGCAVDQHLTDQLIPYLALAEGESEITSAELTSHTLTNIELVKQILGTEFEVDGEKGEPGRIQAKGRSDSAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDE0</accession>
    <name>A0A133VDE0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04463">
        <property type="protein sequence ID" value="KXB04463"/>
        <property type="gene ID" value="AKJ48_02490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="97" mass="11424" checksum="2F6E2E6B01853654" modified="2016-07-06" version="1">MMGNIIVYRQPSSSKSRQLSRSLHGYVDKSNYGKYTYERDGLLDKIPYRKLIKGVFIVRERDLQKFVELLEKYQAEYNVRNVELTAEDEEILSSQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDF9</accession>
    <name>A0A133VDF9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps5</name>
        <name evidence="8" type="ORF">AKJ48_02425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04483">
        <property type="protein sequence ID" value="KXB04483"/>
        <property type="gene ID" value="AKJ48_02425"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.348"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_S5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="220" mass="23933" checksum="9C94450C3B816C20" modified="2016-07-06" version="1">MENPELEDWIPKTGIGRKVKEGEVTDLSQILRSGKRPREPEIIDALVPDLDEEILGVNLVQRMHRSGRRIQFRVTTVVGNEDGIVGVAHASGREVGPSIRKSITTAKLNVIEIVRGCGSWECGCSRPHSLPYEVSGSKGSVEITLKPAPRGLGLAAAEVPRLILEKAGVGDVWTRTSGKTRTTINFALATFDALNQAAKMEVRGTYAERIQIGEVGEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDG9</accession>
    <name>A0A133VDG9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GlutR_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000029">
        <property type="protein sequence ID" value="KXB04471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04471">
        <property type="protein sequence ID" value="KXB04471"/>
        <property type="gene ID" value="AKJ48_02530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_dimer" evidence="2">
        <location>
            <begin position="78"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="138" mass="16328" checksum="8AF37BE0737FD82B" modified="2016-07-06" version="1">MTEDKIPELSEKKVLLDLSVPTNVHPKVRESKMIEYISYEELSKKARENLLNRSGEVEKIRKMAREEVENFQEEDPYEDIYKEVEVIRREQVEKAKKELEKREETKVLQDFSRSLTKKILSVVKKEINKNERSSGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDH5</accession>
    <name>A0A133VDH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_02355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000027">
        <property type="protein sequence ID" value="KXB04499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04499">
        <property type="protein sequence ID" value="KXB04499"/>
        <property type="gene ID" value="AKJ48_02355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.334"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="313" mass="34455" checksum="A25EE6A75A5D6257" modified="2016-07-06" version="1" fragment="single">GALINVDNLQELKVINDLSEKIGKEARIGFRVNPDVKAPTHPHIATGLRESKFGFDVESGKALEAYQIASEMERVKVEAIHSHIGSQILDPKPFGEQAEKMMNLVAQIRDEVGVEIGIVDMGGGLGIPYKPDEEALSPDDMAEETTSTMKKIIQEKDLSKPTLVLEPGRSIVADAGMLLGRVGYTKEREKTTDWVAIDAGMNALIRPVLYDAYHHILAANKMNEKTSETYNVAGPLCESGDYLGKERKLPKVERGDLLAVLDVGAYGLAMSSQHTAQPRPAMVLVNSGDVEIVRRREECKDLTRLDKVPEWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDI9</accession>
    <name>A0A133VDI9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04518">
        <property type="protein sequence ID" value="KXB04518"/>
        <property type="gene ID" value="AKJ48_02350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="306" mass="35440" checksum="35C230D37B49DE57" modified="2016-07-06" version="1">MENFSVKEIVAIHGLSSHVFQGGAEPLIWGYYLKKDELYSELLKRRVLTTRGIVKAAEGIVSNPTTRHVLKKYVSRFIEDGKLVRIRRGLYAALAPLDDPETFIPDKFLVGTKVRSEGFLGYHTALEFHGCADSPVYNTIYVCVNPSKRFDKFSFRGLHFKPILVQDTETGVIEEKYLGQQVRVSNMERTFVDSLDRVNYVGGWEECLKSLETARGLDFNRVIDYTLKRDNEFLTRKIGFTLELLRDTSTFYEHLDDEHLKKLSDQVGKSPRYLEGARSPEETKTLNKKWRLYLPHQFEERFLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDJ2</accession>
    <name>A0A133VDJ2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04512">
        <property type="protein sequence ID" value="KXB04512"/>
        <property type="gene ID" value="AKJ48_02320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="136" mass="15822" checksum="DDC712B59C0291DB" modified="2016-07-06" version="1">MRLINLENGKVIADKVELANSFWKRFRGLMLKGNFRSGQALVFPFSKPKRYSIHTFFMRFPIDLLYLNQKLEVIESRKELSPWKTHKSEKEASILVELPPGRIEEANVRVGDELDFREKGESINFCDFSPTLCKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDJ8</accession>
    <name>A0A133VDJ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000025">
        <property type="protein sequence ID" value="KXB04528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04528">
        <property type="protein sequence ID" value="KXB04528"/>
        <property type="gene ID" value="AKJ48_02275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="281" mass="31676" checksum="4637194F4F9A0E16" modified="2016-07-06" version="1">MPRKIRLGPAGNPADYSGPSVNAPEFIREEGLSAYEYQGTRGVRISEENAQKLSENAEENDVWVTIHGQYWINFASAKKDTIEKSKDRLFKAARIGSLMGAHQVVFHPAYYSDRSKEEALKITIEGIKEVVERLEDEGIEILIGPETTGRKSQLGTLSEIIKICQEIPMTAPTVDFAHIHARTGGTLETKDDYLKIFEQIEDELGAKSAKNLHAHFTEVEFTEKGEKKHLTYETDYSPPFKPLAEVVVENDFTPVIISESPILDKDALKFKEELEKLGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDM1</accession>
    <name>A0A133VDM1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin:thioredoxin reductase</fullName>
            <ecNumber evidence="5">1.8.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ferredoxin-thioredoxin reductase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AKJ48_02230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42336"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ferredoxin thioredoxin reductase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.2" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000024">
        <property type="protein sequence ID" value="KXB04542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04542">
        <property type="protein sequence ID" value="KXB04542"/>
        <property type="gene ID" value="AKJ48_02230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004209">
        <property type="entry name" value="FTR_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036644">
        <property type="entry name" value="FTR_bsu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35113">
        <property type="entry name" value="PTHR35113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02943">
        <property type="entry name" value="FeThRed_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57662">
        <property type="entry name" value="SSF57662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB04542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="92" mass="10729" checksum="97372B6AB0684E84" modified="2016-07-06" version="1">MNFEQLFKELKDYAKSQDMLKLNPDEEKVVWVIKGLLKNEEKYGHRYCPCRVVTGNEEDDAPKICPCKWHKDEIKEMGHCTCGLFVSTKGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDN3</accession>
    <name>A0A133VDN3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04563">
        <property type="protein sequence ID" value="KXB04563"/>
        <property type="gene ID" value="AKJ48_02180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="94" mass="10996" checksum="1E4D6ED35B1AEED2" modified="2016-07-06" version="1">MEKVLWWLIGGTRGGKNRLRIIKKLRDEPMNANQLSEELDLDYKTIRHHLDALEENKIITSIGDGYGKNYFLSDWMEDNIESLKKITREADMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDN5</accession>
    <name>A0A133VDN5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000024">
        <property type="protein sequence ID" value="KXB04545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04545">
        <property type="protein sequence ID" value="KXB04545"/>
        <property type="gene ID" value="AKJ48_02260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="72" mass="7570" checksum="F0AA45735AB877B1" modified="2016-07-06" version="1">MEDDLEKVGYLKRLGHKTMGTVRENIIISILTKGALAVLAVFGLVSLAVAVGVGDMGISFVVIANALRLGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDN7</accession>
    <name>A0A133VDN7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LMWPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000024">
        <property type="protein sequence ID" value="KXB04541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04541">
        <property type="protein sequence ID" value="KXB04541"/>
        <property type="gene ID" value="AKJ48_02220"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.305"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="130" mass="14365" checksum="1DD16C7ED30409E0" modified="2016-07-06" version="1">MRILFACVGNSARSQMAEGFAKHYSDDIQATSAGTSPASKISKKAVKVMSEKGIDISQQKPSLINPSEVKDVDLIITMGCGPDACPTAPPEKVREWKIDDPCGRSIEDFRKIRDKIENKVRELIKEIRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDP8</accession>
    <name>A0A133VDP8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000025">
        <property type="protein sequence ID" value="KXB04527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04527">
        <property type="protein sequence ID" value="KXB04527"/>
        <property type="gene ID" value="AKJ48_02265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="77" mass="8467" checksum="FBE6DACBF20FDF68" modified="2016-07-06" version="1">MAEEEEGPVCAVPGCERELSEEQVESGMIVCEKCEAAKMHLCEACGKKLSPEQIQAGAVLCENCEERLEMGIDYEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDR6</accession>
    <name>A0A133VDR6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase assembly protein HupF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04575">
        <property type="protein sequence ID" value="KXB04575"/>
        <property type="gene ID" value="AKJ48_02125"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.284"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="359" mass="39438" checksum="A392710526433B67" modified="2016-07-06" version="1">MELLEKYRNKDTADEIVASINQITPEGPVKVMHVCGTHEFTIVRHGLRSLLPENIELIAGPGCPVCVTPAREIDEAVKLAGQEVLITTFGDMFHVPGSNASLEGVKTDGADVKIVYGVSDAVEIARENPDREVVHVAIGFETTAPTTAAEILSEPPKNFSILSCHRLIPPAMEFLLNSGESEIDGFLCPGHVSTIIGSKPYEPISKEFGVPQVVAGFEPLDVLLGVLMLLRQIRDARGEVENEYTRAVKLEGNKLAQEKMREVFKITSENWRGFPTIPDSALELRDEFQQYDARERFDIEIEETQEFAEGCRCGEVLRGLINPSDCPLFLKACTPDSPKGPCMVSFEGTCSVWAKHGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDU6</accession>
    <name>A0A133VDU6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04577">
        <property type="protein sequence ID" value="KXB04577"/>
        <property type="gene ID" value="AKJ48_02135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="107" mass="12763" checksum="B6188BD6E053A6A4" modified="2016-07-06" version="1">MDEEALRKILESGYDLTWTDTEGVKIKPSESSDKEPKIDEETEIEPWHLAEKYHQERKEKSPEEAWKHITDEIKSEPTRYFHQWSVGSTDRGDFIIKKVREELDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDV7</accession>
    <name>A0A133VDV7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NFACT-R_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000019">
        <property type="protein sequence ID" value="KXB04629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04629">
        <property type="protein sequence ID" value="KXB04629"/>
        <property type="gene ID" value="AKJ48_01965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.221"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="454"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="648" mass="74167" checksum="DAE65508DE518959" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDX7</accession>
    <name>A0A133VDX7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="4">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcm</name>
        <name evidence="5" type="ORF">AKJ48_01865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04649">
        <property type="protein sequence ID" value="KXB04649"/>
        <property type="gene ID" value="AKJ48_01865"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.203"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="221" mass="24225" checksum="1FAB11C49FB14C8F" modified="2016-07-06" version="1">MSNDRAEEMANRLKQIGYLRTPRIIDAFRKVPRHEFLPEKMRGDAYLDHPLPIGHGQTISAPSMIAIMLEVLQPEEGDKVLEIGTGSGYNAALIAEIIGKTGGIYTIERLKEIAELGEENLRKAGYEWVNVVVGDGTQGYEEEAPWDKILVTACAPKIPEPLVNQLKIGGKMAAPVGQNYMAQTLTLLEKTGENETSIQKHGGCAFVPLIGEDGWSEEQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE34</accession>
    <name>A0A133VE34_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="7">IPP isomerase</shortName>
            <ecNumber evidence="7">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="7">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fni</name>
        <name evidence="9" type="ORF">AKJ48_01705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04699">
        <property type="protein sequence ID" value="KXB04699"/>
        <property type="gene ID" value="AKJ48_01705"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.169"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="290"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="359" mass="38735" checksum="D2DDE10C91150AC6" modified="2016-07-06" version="1">MGKKTSERKLDHLKICLEEDVEARTKTTGFNDINLIHQASPEMDLDEVDLSSSLFGKDLEAPILIAPMTGGHKRGQEMNLALAEAAQELGLAFSVGSQRAAIEDSKLEETYQVRKVAPDVLLLGNLGMAQFTRDYGPDEARKAVEMVDADALGIHLNPLQEAVQSEGDPYYDTGVESFSKLASKLDVPLLIKETGAGISTSIAIKFEKAGASAIDVSGVGGTSWAGVEALREKTDQSLGEAFWDWGIPTAVATTEVSEAVDIPVISSGGIRTGLDAAKAFSLGADLVSVALPLLRASAKGKDEIVSWLNNFIQELRVTMFLTGCKQVADLRKVSLSITGRTREYFKTRGLDLTKFERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE35</accession>
    <name>A0A133VE35_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04667">
        <property type="protein sequence ID" value="KXB04667"/>
        <property type="gene ID" value="AKJ48_01795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002829">
        <property type="entry name" value="DUF116"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43801">
        <property type="entry name" value="PTHR43801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01976">
        <property type="entry name" value="DUF116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="204" mass="23419" checksum="08B6EDFB41B540A4" modified="2016-07-06" version="1">MAYEFNFDLTKVSRSFFRELAKFSDHKGIHRKIGDFVKSVIDRFKIQRLTGLPLSDAVKVIDDLVDIYAKNLSHEEEFEKTANRALFLPHCSRKYMDQRCQAEFDPKLSTYKCQHCSEDCLINKASEIGEERGYDTYILPGGSCIPKILNGRNYEAVVGVACPHEIQLAMRHLEEIGLPYQSVPLLRNGCSNTEFNLETFEQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE36</accession>
    <name>A0A133VE36_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">infB</name>
        <name evidence="9" type="ORF">AKJ48_01745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04695">
        <property type="protein sequence ID" value="KXB04695"/>
        <property type="gene ID" value="AKJ48_01745"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.177"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_A">
        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="6"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="79"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="597" mass="66543" checksum="D159C0181EB4F659" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE72</accession>
    <name>A0A133VE72_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04753">
        <property type="protein sequence ID" value="KXB04753"/>
        <property type="gene ID" value="AKJ48_01475"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.121"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="469" mass="54438" checksum="78A22A9E01849C51" modified="2016-07-06" version="1">MDDSNIVFIIVDALRTDKVGCYGHGKTITSNIDDLAREGTLFENNYACINVTDPSLTTIFSGRYPISHGLINHGPHIREDDLRKLSESGTRFLPEILRTKGYATLAVDWLGRWHKQGYDYYSGLRPAFFRMMRMLSHRPSKIFTLIKLLYLYRKAIPELRVLYDEVITSQAIELMKKFQKQKFFLFVHYWGTHAPYISPENPQILESPQSEEIDLTRSLIKSVAPNREMYHLRWFDEDLTIGEILSRYEGAINFIDGQIGELMNELDELGLRENTLVVLTSDHGESLTEHGIYFDHHGLYDVSLHVPLIFRGSGFPEDLRVSGTIQHVDIVPTILNNLNYNVRGMNLDGKDTSPLIRGEAEEFRTEVYAEEAEAQRKRAVRTRDYKYIFAPSEAAAKCQYCNCIHGEVKELYDLRKDPQEVENILNDEKERGKELKNKFLNWSRKLKQEKLERERIREKIGKLKKLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE90</accession>
    <name>A0A133VE90_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04759">
        <property type="protein sequence ID" value="KXB04759"/>
        <property type="gene ID" value="AKJ48_01505"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.128"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="201" mass="22419" checksum="6BA5DC4F803907DE" modified="2016-07-06" version="1">MGKRTVSKHDIIELGVLFATLAIVTIMAFYTPLKIEWVWRAPQLLVPFAILLVHHKSVKSIGLDVRNFPQNMGLGILAAILLTVGLAPIYLWLWSPTMPTSLYLDVWAWVTIFVIANALVIEIFYRGGLQSRLTKLTGFMPALIITSLLCGIDFFEFMIFGPITAVIAAAVSGFLYYKTETLVAPITAHILWPLLIMMLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE96</accession>
    <name>A0A133VE96_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04717">
        <property type="protein sequence ID" value="KXB04717"/>
        <property type="gene ID" value="AKJ48_01665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="146" mass="17022" checksum="9097D28F222C9B1F" modified="2016-07-06" version="1">MVKDVGTNEKNTFTDSDELRSRFVIREEEEFEKLVEGAEELVKIREETGEPKVLLSPKRGSVKDRLFLYFLGTEVSFRLGLREERSVSTDELCQHFKLSRNYGNARVSDLHDENLIEKVDRGEYKLDLIHSFDYIRALKAKYGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE99</accession>
    <name>A0A133VE99_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04778">
        <property type="protein sequence ID" value="KXB04778"/>
        <property type="gene ID" value="AKJ48_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="145" mass="16584" checksum="16CAF06AF327EE97" modified="2016-07-06" version="1">MERVLIDTNVMVIGARDYAEDKDTPGSIILKLALKNKIKVIMNPTLLKEYHRVAVDLEGKDLAGWFRNVIMKDLSISYVDETAIKRLMERYDGEVPSEDLPHFASCLLGGVDFLISVNRDFLKKTSKFNFRCVKPKEYLKESDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEA3</accession>
    <name>A0A133VEA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04776">
        <property type="protein sequence ID" value="KXB04776"/>
        <property type="gene ID" value="AKJ48_01410"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.107"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="301" mass="33802" checksum="EF1E5FF720439497" modified="2016-07-06" version="1">MKVLVTGGAGFIGSNIVERLVERGDDVTVLDNFSTGSEENLEKVWDQIQIIKASCSDIPQLDLDDFELIFHIGIPSSSPMYKENPLLVGEAINDFIKVMELAKSTGARVVYASTSSMYAQCSPPHREDMEFEPFDYYTEARLVMERLAKVYHELHGVESVGMRFFSVYGPHEQAKGKYANIISQFYWKMKEDEKPVIYGDGEQTRDFTHVSDIVDACLTAAESNIECDAVNVGTGRATTFNQVVELLNQELGKSIGPKYVENPIKNYVYHTQADITKAKKLLDYEPNVTLEEGIKKLVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEB0</accession>
    <name>A0A133VEB0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04737">
        <property type="protein sequence ID" value="KXB04737"/>
        <property type="gene ID" value="AKJ48_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="65" mass="7617" checksum="D36D3550C406C40F" modified="2016-07-06" version="1">MGNIKVILPDDLEEEFREEIYKSKGMKKGNIKKAIQEAIVLWIEAEKEKRSQAAKKAWETRKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-06-17" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEC0</accession>
    <name>A0A133VEC0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04754">
        <property type="protein sequence ID" value="KXB04754"/>
        <property type="gene ID" value="AKJ48_01480"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.122"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="241" mass="27471" checksum="9CABE6AED2F380FB" modified="2016-07-06" version="1">MEKISVIIPTYNERENLPKLLKKIGKVFEKNKIIGEVMVVDDNSPDGTGELAEKLKEKYDFLKVIHRREKLGLGSAYLDGFKKSSGELIFTMDSDLSHDPRYLPQFLDATEDADLVVGSRYIPGGEIVGWGAYRKLVSKIANFLARLSVRGGVKDVTSGYRCYRRKVLQEIPLDKIQSSGYAFQLEMMYEARKRDFRIKSVPISFVDRRQGKSKLGVFDILNFLKLTIKLGLKDEVTPRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEF2</accession>
    <name>A0A133VEF2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04805">
        <property type="protein sequence ID" value="KXB04805"/>
        <property type="gene ID" value="AKJ48_01360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="267" mass="29586" checksum="B1B5882B0FE40455" modified="2016-07-06" version="1">MRKLALASLVTLVLLSSVGSCIATSSNFYTRNGEKYDNWSLCRTRCWGEDGFFQVHNTTFRPAIAFESLGELKNTAWEVGEGLAERYSGNELAKQIFDYVRDHVIYTSDSIQFAYDEFARNADEVAEEIESNGSSRGDCEDYAVLLAVMFKAAGFQSAVVLAPEHAAALVYLSGYPGANAFWDFRGEGGWIWAEATGRTNPLGWTPPELMRSDLLAYEIGEEPVLEGEGKSEKLATSGGGGQMFFGGSSFFSMLLFLWVLSLFKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEH3</accession>
    <name>A0A133VEH3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">AKJ48_01280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04825">
        <property type="protein sequence ID" value="KXB04825"/>
        <property type="gene ID" value="AKJ48_01280"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.906"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="6"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="393" mass="44032" checksum="07F2FBAFFEF0E16C" modified="2016-07-06" version="1">MKVVLAFSGGLDTSVCLKLLQDKYEADVVTLAVNVGQDPEKLEEIKEKAEKLGAIKHKSFDLTKEFVENYVFKSIKANGLYEGYPLSTALARYPIAVRLVKEAHKEKADAVAHGCTGKGNDQFRFDTTISLQDPDLEIIAPVRELNLTRSWEIGYAKEQGIPIPVDIDQPYSIDENLWGRSIEGGNLEDPKNEPPEEIYELTQSPSEAPDPEVIEVEFEEGIPINLNGKKMDGVSLITKLNQIAGEHGVGRIDMIEDRALGLKSRENYEAPAATVILTAHKALEKLVLTRDELKFKESVDSLWADLVYRGSWFDPLREDLDAFIDNTQERVTGQVRVKLDHGSARVVSLESPFSLHEPELVSFEEFGFDQQESTGAIKFQSLQGRIFRKRQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEH5</accession>
    <name>A0A133VEH5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04846">
        <property type="protein sequence ID" value="KXB04846"/>
        <property type="gene ID" value="AKJ48_01180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="82" mass="9758" checksum="777B1A451577E989" modified="2016-07-06" version="1">MKWLSIVQIVAGIMSREVKTVVDVDHDCLENLEEHPREVEVWCEETVQVRKKCTVCGHEIHELYDIAAFYDETEGRWIKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEJ3</accession>
    <name>A0A133VEJ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04866">
        <property type="protein sequence ID" value="KXB04866"/>
        <property type="gene ID" value="AKJ48_01060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="170" mass="19374" checksum="A107A5DA2F3DF447" modified="2016-07-06" version="1">MVWIEKTGPDTHEEEEHHVGDHQIKIRRGGRKKKLDRVEIKQGIFGKRTVTKADVDRINAEVEKGTFPKKLGILVKFAIKGLGEETNETLKWIEENPRYLKLLKILQNNAMSITQIARELGVKYATANGYAGSCAERGAIRRKKRGRGYRAEITESGRKILNLLDHSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEJ5</accession>
    <name>A0A133VEJ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04845">
        <property type="protein sequence ID" value="KXB04845"/>
        <property type="gene ID" value="AKJ48_01175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="106" mass="12005" checksum="2114C26B995C8062" modified="2016-07-06" version="1">MGADFLCYILEMDHGEEPDWETAEKYIEETPVDELRTVSRELLKEYLTNLKDWWNGDTPRSVVNIKLKHTNALATGGMSWGDNPTEAFGEIATLDEAGILDVLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEK3</accession>
    <name>A0A133VEK3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04844">
        <property type="protein sequence ID" value="KXB04844"/>
        <property type="gene ID" value="AKJ48_01170"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.841"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="134" mass="15403" checksum="BC820BA65C6324C2" modified="2016-07-06" version="1">MTAGDETPYYTNSTHLPVSETDDLIRAVEHQESLQKLYTGGTVLHAYAGERLDAEATRTLVKMLAEKSELPYYTLTPTYSICPDHGYVPGEHFECPHCCKTTEVYSRVVGYYRPVQRWNDGKQEEFSERKQYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEK8</accession>
    <name>A0A133VEK8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04878">
        <property type="protein sequence ID" value="KXB04878"/>
        <property type="gene ID" value="AKJ48_01120"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.783"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="76"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="174" mass="19651" checksum="9DCDFFF140F85DDF" modified="2016-07-06" version="1">MDYEGSLAFLGDLEEVLRKGGTWLADKKPIKSIRDWAINFSLWPVHLTTACCGCEFAAAAGPRFDMERLGILPWVGSRQTNVLVIEGTLTRKMAKAARIVYRQMPEPKFVIAMGSCASDGGIFWNSYNIVKVKDVLPVDVYIPGCPPRPEAILRAFMEIKEKNKEKLRYHEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEL3</accession>
    <name>A0A133VEL3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_01125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04879">
        <property type="protein sequence ID" value="KXB04879"/>
        <property type="gene ID" value="AKJ48_01125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="141" mass="15899" checksum="7C8FAC6130DE595C" modified="2016-07-06" version="1">MFEFVQPIQTLNAAAIVPRPTLITILLALVLPSIGILIGATLARVLTPREYSVEKLDRYEAGNPPYGRARGFFPMQYYPYLIIFLTVEPVMIYLFLVLMALHESTIAVGLLFVGLSVLLALPLVFALDSARRLKYWIMREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEP6</accession>
    <name>A0A133VEP6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04923">
        <property type="protein sequence ID" value="KXB04923"/>
        <property type="gene ID" value="AKJ48_00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="90" mass="10748" checksum="ACC822E0275504D2" modified="2016-07-06" version="1">MRKILLIWDVKSRGTPATSFYRELRGYDYKTKSGKCHTDGVLDELPEDVWDFVSRSALIVEKNHVKKIEKVFKKYGTHLEWVKYEVREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ2</accession>
    <name>A0A133VEQ2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">AKJ48_00885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04919">
        <property type="protein sequence ID" value="KXB04919"/>
        <property type="gene ID" value="AKJ48_00885"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.626"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="178" mass="20182" checksum="E614CA1AD3F200AD" modified="2016-07-06" version="1">MVRNQTKISKYLAYLLRHNPSGMKISREGFVSLEELLGKLRKRWPNLSEKDLQRLVKEDSKGRYEIKGREIRARYGHSIDVNPTLPEAKVDKLYHGTTYEASQKILEEGLKSKGRQKIHLSASIEDAVEVGKRRTSNPVVLAVNVKGACRAGIRVENASDKVFVAHRIPSRFISKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VER5</accession>
    <name>A0A133VER5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NMD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04931">
        <property type="protein sequence ID" value="KXB04931"/>
        <property type="gene ID" value="AKJ48_00955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="PTHR12746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="259" mass="29138" checksum="83F4FC497105B0EF" modified="2016-07-06" version="1">MQKFCYKCGALEEEKGPLIEGLCQDCFTSEHPLIKTPDQVELRVCGRCGAYFLNNKWHDPREKSELSLLRASEELVHSEIKVAQVQPTGVRYVNLEEASGIDVELESESVPQGIKVEIRARGKIHESQESSQTAEGVVRVKVETTTCDVCSRKSAGYYEAILQVRGEIPLSRKRLREVYQALESTFLEEQSRNRGEFVSKIEEKHGGLDLYTSSTTLARHLAEALKEKYGAKTDESSKLIGQTSDGRKKYRVSIVARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VES6</accession>
    <name>A0A133VES6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04949">
        <property type="protein sequence ID" value="KXB04949"/>
        <property type="gene ID" value="AKJ48_00800"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.526"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012027">
        <property type="entry name" value="Formylmethanofuran_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006453">
        <property type="entry name" value="FwdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03121">
        <property type="entry name" value="one_C_dehyd_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="36"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="553" mass="61325" checksum="3072E58E8CE3502C" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEV6</accession>
    <name>A0A133VEV6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_00845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04957">
        <property type="protein sequence ID" value="KXB04957"/>
        <property type="gene ID" value="AKJ48_00845"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.535"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="501"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="742"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="894" mass="99764" checksum="731BB11BE87E17BA" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX9</accession>
    <name>A0A133VEX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04992">
        <property type="protein sequence ID" value="KXB04992"/>
        <property type="gene ID" value="AKJ48_00670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="109" mass="12486" checksum="5173768894086E94" modified="2016-07-06" version="1">MKRGLKTFSRAVRDGKIEKAQEMYEKIVQGNMDDGLWEGYQTALKGMIEALDSGDDLTLPRQIADGKYSKKRLKKIRKEMVSRASQEFRAADERGFNMAWADVLKVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF24</accession>
    <name>A0A133VF24_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05030">
        <property type="protein sequence ID" value="KXB05030"/>
        <property type="gene ID" value="AKJ48_00490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="189" mass="21142" checksum="306CB5DBDFBAD994" modified="2016-07-06" version="1">MEAEGTLKSRTAERKGKGRGRRLYYKYSSDIGAYLDFLKKFVGAGEKTMEEVKEVVLGFAPVLNKIGPADIPRVNAIQDISFCAAIPEYFLHLNLTREEIKESLFETLDEINPKTGLTQSLLPISKPLVVPVTERLFQYPRDIDLPKNVLEKAAKNRLTFVTAMWASSQVAADKLSPKLKKGLEEVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF28</accession>
    <name>A0A133VF28_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SO_alpha_A3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05042">
        <property type="protein sequence ID" value="KXB05042"/>
        <property type="gene ID" value="AKJ48_00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041117">
        <property type="entry name" value="SoxA_A3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17806">
        <property type="entry name" value="SO_alpha_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SO_alpha_A3" evidence="2">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="89" mass="9900" checksum="C253E37B5F24CD5D" modified="2016-07-06" version="1">MGKIIICPCEDVTQKDIERAIELGFTDIDTLKRFTGIANGPCQGRICLTQVRRILAKHLDKKIEDVPVPTQRPPITPPYLGVIAGEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF31</accession>
    <name>A0A133VF31_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_00315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05058">
        <property type="protein sequence ID" value="KXB05058"/>
        <property type="gene ID" value="AKJ48_00315"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.58"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="122"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB05058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="489" mass="54828" checksum="9A25943BB189DC3F" modified="2016-07-06" version="1">MSGAVREESVDVRRRDEAVAGTVQRWLGNPLSRALLRLVTGRTEHGNRLNIALKKYAGEEVPEDLGFRDKLASMLIGFVIGRGSESFGVSPEEMKETLRDPIIRRGIANVIEGIAQYGIQRPYTSVAPFLVVWDYTRLCNLRCKHCYEDASPDADTSEELTTEEAKQVIDEFKEAGIVAIAFSGGEPLSRDDFFEVAKYAKDQGFFVSIATNGTLITREVANKLKDVVEYAEISLDGFEETHDEFRGIEGCWKRTCEGIRNSVEAGIDTCVALTATHYNLDEISELIEFAEKDLGARKAIIFNYIPVRKGREIIDEDLTPQERWGLLEDLYSKLLDEDNPMTLYSTAPQYAAVSWEFAHGPAIATHFTNEAAMQALQGRTKTLAQFLGGCGAGRLYCALEPNGDVEPCVFIPIKVGNIREQSLREIWQNSEVLDKIRDREHLEGCSDCDYKYICGGCRARAYAYYGDLQGPDPSCPENENYWKELKNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF47</accession>
    <name>A0A133VF47_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05062">
        <property type="protein sequence ID" value="KXB05062"/>
        <property type="gene ID" value="AKJ48_00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="99" mass="10400" checksum="AF494A1D20E36598" modified="2016-07-06" version="1">MKNPKGGENMAKLKARELVGPAAFYVGLLIAIGAAFIEPTGWLYVALGIIGVIIGLLNITARETGPFLLASIAFIVAALGMWTLINSAFGAALITHQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF52</accession>
    <name>A0A133VF52_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ48_00355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05065">
        <property type="protein sequence ID" value="KXB05065"/>
        <property type="gene ID" value="AKJ48_00355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.66"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB05065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="630" mass="69350" checksum="3FDEC8342E9855ED" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF71</accession>
    <name>A0A133VF71_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05067">
        <property type="protein sequence ID" value="KXB05067"/>
        <property type="gene ID" value="AKJ48_00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="190" mass="22227" checksum="0D10A3353458CC37" modified="2016-07-06" version="1">MRVRKTIQSGVVNLTKVKRRILTEEYENLQKFLHGKKNVELYSANKQQGERYYKKIKDGKKYPISIRKDLIDVRECESNVCDYFVKIPVAGRYGGVKVPINTHTEIEDDWEICESKLYRKNDRFYLNITIEIEVKEVQEYNGVLGIDLGLRNPVVSVALPSREAKFQGQKIKQIQSKYFYLRQQSKTGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF76</accession>
    <name>A0A133VF76_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05096">
        <property type="protein sequence ID" value="KXB05096"/>
        <property type="gene ID" value="AKJ48_00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="103" mass="11404" checksum="C5257D937DC1C17C" modified="2016-07-06" version="1">MLKAYRSTLLCCLGGGLQMRVSEYYDMPIYSDRARYVGEVQDVVLDVDEGKVLGLGFGYRGGKVTSVPYESIVAIGDIILVESKRTVEQTTIEQEAVEEESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF97</accession>
    <name>A0A133VF97_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="6">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ48_00045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="6"/>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05097">
        <property type="protein sequence ID" value="KXB05097"/>
        <property type="gene ID" value="AKJ48_00045"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006401">
        <property type="entry name" value="Rib_reduct_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01508">
        <property type="entry name" value="rib_reduct_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="10">
        <location>
            <begin position="4"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB05097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="223" mass="24186" checksum="03C09897D10643F3" modified="2016-07-06" version="1">MDRPNVILNAGMTLDGKISTIGGDSKISCEEDLKRVHELRAKVDAVMVGIGTVISDNPILTVRRAKGRNPIRIVVDSLGKTPSDAKILDGSAQSIVAVTTRASEKEKNRLQDKGAEVLVLGDEKVDLTQLLEHLRKRGVEKLLLEGGSTLNWSMLHQRLVDEIQIAVAPKIVGGKKAKTLVDGVGVRKIADGVHLEFQSSKIVGENLLLTYRVKGLTNDSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF98</accession>
    <name>A0A133VF98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ48_00195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05119">
        <property type="protein sequence ID" value="KXB05119"/>
        <property type="gene ID" value="AKJ48_00195"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.35"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="151"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="253"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB05119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="449" mass="49132" checksum="87E98F8FB0793369" modified="2016-07-06" version="1">MGKLFGTFGVRGIVGEEVTPDLAYNLGLALATHLNGEGKVAVGYDTRTSNVMLEHAIVSGLTAGGCDATRLGMVPTPVLSFGIKHFSCDAGIVITASHNPPEYNGFKFWDEEGAGFVREREREIEELFEKGGELKNWDEFGRAVKADALSPYLDSLADRVPEIDQELKVVVDCANGAGSVATPEILSRLGCKVIAMNSQPDGSFPGRLPEPTPEHIQELVKTVKSTDADLGIAHDGDGDRTIIVDESGEILSGDRVFALVALHYLRGMENPRIITTVATSSVLDDVAEQLGGEVVRTRVGEPDIISEYRENDGDLGGEENGGVIFPDWLLCRDGVMTAIQFVEYISQTGEKVSEVNKTLPEYHQFKKKTDCPDKLKPKVLDDLAKKFEHYNPDRTDGVRVVLEDGWFIVRPSGTEPIFRCFSEAQTEERAEELVEEGMQALEESISKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA0</accession>
    <name>A0A133VFA0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05110">
        <property type="protein sequence ID" value="KXB05110"/>
        <property type="gene ID" value="AKJ48_00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="204" mass="23629" checksum="8CD6D798A880A88B" modified="2016-07-06" version="1">MKKHQIALREILYQNYEKRKKFLSQKSISEACGASIGTVNSVVKKLGDLGVIEKKPLGFRIRDVKKVLHYWAATRDLEKDVVYTAYSPDLPKTIEEKIPPEVAFTAYSGFRRRFGVTPTDYSKVYLYGDPNQIARIFRQKKKERNIYVLEQDARLKDLTSEGVVPLVQLYADLWQLPPPANRFLEELKQKLKPTKVKIGKITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA1</accession>
    <name>A0A133VFA1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05105">
        <property type="protein sequence ID" value="KXB05105"/>
        <property type="gene ID" value="AKJ48_00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="93" mass="10515" checksum="FF92C2A412086EEE" modified="2016-07-06" version="1">MSESLPLPPKTEGRGPTLSTIHEVEQILRDAEGPLSLNEIKRRMSAKAVRHRTVRQVIDEFKRLGFVAEGSKGVIWTLNLSPELWTKGRVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA7</accession>
    <name>A0A133VFA7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05129">
        <property type="protein sequence ID" value="KXB05129"/>
        <property type="gene ID" value="AKJ48_00260"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.47"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="204" mass="23219" checksum="E756A3A74B2997A9" modified="2016-07-06" version="1">MDTAEKDSIRGEMKSRRRELAREEVLAKSDQIQNSLFSQAEFAKAKTISFYVAKQEDREVETEHMIKDCLQGDKQILVPLVSGETELSLCELEDYDRELEPGAFGVLEPKPSCRRIRPLEQTDLLIVPGLAFDLQGYRLGYGGGYYDNLIQDASSTQPNISTIGLAYEFQILEKLPHEPHDMPVDKVITEEREIHTSSNRPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA9</accession>
    <name>A0A133VFA9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05120">
        <property type="protein sequence ID" value="KXB05120"/>
        <property type="gene ID" value="AKJ48_00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="242" mass="28553" checksum="2E49AADDC246DBF6" modified="2016-07-06" version="1">MVVVFAIDALEHELVEEFDCKNLKQVTYGKTDISEFNQPRTMVLWSSFMTGENKEEEILAKGDEEMWKTKIPLEETFFSNFENPKIIDLPGFSYDRKQHDKERELLKKFFEEAEDQEEKKEIRKEYNQHGLKHHRKIKEEFLNSLEKDHDFVLGYFSAADVIGHLNFCNKTLMKMIYNDLDEIAGKIKEIRDDHLLVLSDHGMEGVGMFGDHNEYGFWSFDEECDLENPKITDFADFLTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V970</accession>
    <name>A0A133V970_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWI2_SNF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_04350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000095">
        <property type="protein sequence ID" value="KXB02981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02981">
        <property type="protein sequence ID" value="KXB02981"/>
        <property type="gene ID" value="AKJ48_04350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.942"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI2_SNF2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="565"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB02981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="698" mass="82569" checksum="DA67F800DE179A73" modified="2016-07-06" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V986</accession>
    <name>A0A133V986_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Big_13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000091">
        <property type="protein sequence ID" value="KXB03040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03040">
        <property type="protein sequence ID" value="KXB03040"/>
        <property type="gene ID" value="AKJ48_04295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="68"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="154" mass="17332" checksum="38EC158D6B75747C" modified="2016-07-06" version="1">MDDNSDVSSPEILENTSSTSYTTSLPLADGNYYWSVRAFNEDNESFGWSDVWSFKIDTVAPNTPVLSSPSDNSTLSDNTPTFQWNEVSGVKDYELLLDNNPGFTSPEVQTVITENTYTPKESLDDDNYWWKIQARDAAGNKSPWSDAWSFTLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V993</accession>
    <name>A0A133V993_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_04355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000096">
        <property type="protein sequence ID" value="KXB02967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB02967">
        <property type="protein sequence ID" value="KXB02967"/>
        <property type="gene ID" value="AKJ48_04355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54_N" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="105"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="106"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB02967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="274" mass="29837" checksum="382CCA926416F706" modified="2016-07-06" version="1" fragment="single">MLENLKQKFKRVTKRITRRGLTPEDIKDISWDLKVELLESDVAVPVADEIIDRLQEEVTGEKLGLREDAEESAREILRGTIGDILTPEREVEILETIKRKQDSGAPAVLLFVGVNGCGKTTTIAKLTKYLQDKGYKPVLAAADTFRAAGIEQLEKHGKKLGVRVIKHERGADAAAVAYDAIEHAKAQNLDAVLIDTAGRMQSNVNLMDEMSKISKVTNPDLTIFVGDALTGNDAIEQAEKFNDAVKIDGSILCKMDADARGGATLSVTKITGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9A5</accession>
    <name>A0A133V9A5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000092">
        <property type="protein sequence ID" value="KXB03022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03022">
        <property type="protein sequence ID" value="KXB03022"/>
        <property type="gene ID" value="AKJ48_04315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="204" mass="23865" checksum="5C6FCD0931A5CF88" modified="2016-07-06" version="1">MKGRYQELFNELVNPKLLTLTLRRSWDLDGLIERAIDGFRRLRRRKILEKALGGLYSVEVKPPTELGWYVHIHVVIDGLFMLQGKLSEEWRDITGDSFIVDIRDLRRRKAGVFYVLGYISSKTKVEETWEGVPKWRKREFEEAVRHRRLIQAFGYFFGTVCASSDSFECPKCGCTEWIFLGVECVSRKKVTLLDWVENVDPPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9L6</accession>
    <name>A0A133V9L6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000085">
        <property type="protein sequence ID" value="KXB03136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03136">
        <property type="protein sequence ID" value="KXB03136"/>
        <property type="gene ID" value="AKJ48_04195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="191" mass="21020" checksum="B75ADAC6D11D4FC9" modified="2016-07-06" version="1">MHSNVSLEGTYLSRRALGIGLALLSIALWVGPIVAAFASNGWNLKETVMPSQDELSRVKDKVGGLTEGGFSENTLQIVDNQMDLTTGEFEATLEFESPFNIDVKITEFSFELYCEQHDFKLVPVQLEENEVSIPASAIVQFDIVGSLTSQGRQHIIDNHGGKLPEPSLENPVFELESYGVTIRMENMELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9M6</accession>
    <name>A0A133V9M6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_04185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000085">
        <property type="protein sequence ID" value="KXB03134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03134">
        <property type="protein sequence ID" value="KXB03134"/>
        <property type="gene ID" value="AKJ48_04185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="70" mass="8151" checksum="9020ACB48053FC8F" modified="2016-07-06" version="1">MISGPSLPVKSHTTNHHNSFKNTRERKQKEIGKISYFELLIYQTDGKGHGPTGSRMKENFEMNFEIELRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9Q4</accession>
    <name>A0A133V9Q4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000083">
        <property type="protein sequence ID" value="KXB03166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03166">
        <property type="protein sequence ID" value="KXB03166"/>
        <property type="gene ID" value="AKJ48_04155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="62" mass="6981" checksum="2B8509F1D502AA86" modified="2016-07-06" version="1">MPWGRVRAITPKTNRGTAEARFPRGTLRFCGHGGEDLEQGRTVFPSPQVLMILIHEKNSTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9V4</accession>
    <name>A0A133V9V4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_04160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000083">
        <property type="protein sequence ID" value="KXB03167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03167">
        <property type="protein sequence ID" value="KXB03167"/>
        <property type="gene ID" value="AKJ48_04160"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.880"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025364">
        <property type="entry name" value="DUF4268"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14088">
        <property type="entry name" value="DUF4268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4268" evidence="2">
        <location>
            <begin position="173"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="317" mass="36845" checksum="F91A5C8808C9A572" modified="2016-07-06" version="1">MEERVGKLTEVPLREIWEDEAEDFTTWLENNVEYLNEKMETILTIVSREKDIGPFHADLVAEDESGEKVVIENQLEKTDHDHLGKLITYMSNLEASTAVWITSEPKQEHTNAVDWLNEIGNRTGMKFYLVKIESYKIGDSLPAPYFSIIAGPSEEAETIGKEKEEDVERLTKRKEFWEKLLEKAEDRLPLYSNVSPSKDHWLSAGAGKAGIHYNFLIYTRGRGGGIQLVISRGKDSRKENKEIFDELHSHRDEIEQEFGERITWRRLDSKKSSRLEVKYDIGGLYQPEKWDELQEKMINGMKRFEDALKKHIVNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA46</accession>
    <name>A0A133VA46_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">AKJ48_04015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000075">
        <property type="protein sequence ID" value="KXB03313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03313">
        <property type="protein sequence ID" value="KXB03313"/>
        <property type="gene ID" value="AKJ48_04015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.822"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB03313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="408" mass="45078" checksum="CC99C543E97A537D" modified="2016-07-06" version="1">MNSKDLYEDAKRLIPGGVNSPVRAFDPYPFFISEGEGSRITDVDGNEYLDYCLGYGPLILGHASPAVMTAILEQLKKGTHFGIPNKAEIKLAEKIVSLVPCAEMIRFTNSGTEATSSAIRLARAYTNREKILIFDGCYHGAHDHFLFDLHKVKSPGIPESIRETTLVAPFNDLERVKSLSEENELATIIVEPVMGNAGCIPPEDGFLEGLRDICNDNDTLLFFDEVITGFRLSLGGAQEYFNVTPDLVTLGKIIGGGFPIGAFAGKKDIMKLVKPEGKVFHAGTFSGHPITMTAGLATLKELENQKVIDKTTKYAEELAETLREESGKTVNQIASMLQIFFTESEVHTADDVRAADKKAYKRFHQALLKKGVFIPPARSECWFVSSAHSKEDLKMTKEVLKETFNEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA62</accession>
    <name>A0A133VA62_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siroheme decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Ahb/Nir family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000074">
        <property type="protein sequence ID" value="KXB03332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03332">
        <property type="protein sequence ID" value="KXB03332"/>
        <property type="gene ID" value="AKJ48_03980"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg2" evidence="6">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB03332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="157" mass="18325" checksum="6DD1D0F9C52F83D8" modified="2016-07-06" version="1">MDLEKEDVRVLKEIQDGIPLEKEPYRRIARKAGIGVRDLLDRLKKLRQNRVIRRFGASVNHRKLGYRANAMVVWNVPDGGIGKIGEKISEFEEVTHCYQRIRYPGKWEYNLYSMVHAASIEECEEIIHRIAREVGIGPDGYEVLYSTRAFKRRGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA85</accession>
    <name>A0A133VA85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_03975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000073">
        <property type="protein sequence ID" value="KXB03362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03362">
        <property type="protein sequence ID" value="KXB03362"/>
        <property type="gene ID" value="AKJ48_03975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.812"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006682">
        <property type="entry name" value="CHP00267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00267">
        <property type="entry name" value="TIGR00267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB03362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="183" mass="18980" checksum="F764D6630D006D86" modified="2016-07-06" version="1">MARLKLMDRYFVRGLVDGSLSCLGVVIGASAAIGLAAPAKWIIIAAGLGGGIANGLSNILGALMAEKAVVYKRFEEVEKSMLKSKAVRDSEVGERRIRKIYSSGIMDGLATILGALLPVIPFFIIGGNLALWASVGLTLGLLFVLGAYVGKISKENLISSGVKMAAFGAAVAVIAALIKMAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAH3</accession>
    <name>A0A133VAH3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MoCF_biosynth domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000070">
        <property type="protein sequence ID" value="KXB03430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03430">
        <property type="protein sequence ID" value="KXB03430"/>
        <property type="gene ID" value="AKJ48_03895"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.793"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="186"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB03430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="414" mass="43870" checksum="9965A923F6B59148" modified="2016-07-06" version="1">MKDFLKVVTLEDAQTKLADHWHPKRQTTIISLEEASGRILAEDVTSKINLPPFDRAAVDGYALQASDTFGVDETNPAKLSRIGEIHAGKQPEIKVGSGTCVAIATGAVMPEGADAVVMVEDASEVNGTIEIRRAVSPGENVSEKGSEIAEEESIALAGQKISPQVHGALHAAGVQEVKAFEKPKVAVISSGEELVEFGKELQLGQIYDINGPTICDSVRACGGEPTHLGIVSDDALEIKKRVRKALSKHDIIITSGGSSAGSKDILPETINELGEPGVIVHGLAQKPGKPTLIAIIKDKPIFGLPGYPVSALMVFNQLVAPYLRELSGIPEPELGSVQASLTKKIISARGRRELVPVKLIQGEEGTLARPLRRDSGAITSLANASGYIDVPLSQEILEEGEIVTVKLYEGSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAR6</accession>
    <name>A0A133VAR6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000067">
        <property type="protein sequence ID" value="KXB03497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03497">
        <property type="protein sequence ID" value="KXB03497"/>
        <property type="gene ID" value="AKJ48_03850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="59" mass="6859" checksum="FFDE4FCF95D6E9C9" modified="2016-07-06" version="1">MSLTLHTLVKAVSMNIWIVIPAYNEERLIGDNIENLKREGYEQIIVVDDGSQDKRREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAT2</accession>
    <name>A0A133VAT2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem I assembly BtpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000065">
        <property type="protein sequence ID" value="KXB03556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03556">
        <property type="protein sequence ID" value="KXB03556"/>
        <property type="gene ID" value="AKJ48_03795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="PTHR21381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="213" mass="23490" checksum="F9A9BB31EA098B5C" modified="2016-07-06" version="1" fragment="single">MVYKAEWAKKLYGKRLDSLEDLFGVNKPIIGMIHLLPMPGAPGCDHDVDLILEKALEDAEKLEDGGVDGLIVENMWDIPYFVGSDIPPETIAIQSVAARKVVEKVDIPVGANVIHNAGRGDLAVALASGAKFMRICLFTGAQVWDTGEFDHGVAAELTRLRRYFNAEDIRIFADIDKKHAKVFPGIDLRTHAIWSEYYLADALIVTGEMTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAV0</accession>
    <name>A0A133VAV0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_03775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aTrm56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="6"/>
    <dbReference type="EMBL" id="LHYB01000064">
        <property type="protein sequence ID" value="KXB03588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03588">
        <property type="protein sequence ID" value="KXB03588"/>
        <property type="gene ID" value="AKJ48_03775"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.743"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB03588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="133" mass="14848" checksum="05CBCECD75A78B38" modified="2016-07-06" version="1" fragment="single">DVRNSLEDVNERWGGSLSIRVTESWREEIKDWQDSGGLAVHLTMYGLPINEKIPEIRENDVLVIVGSGKVSSEVFDMVDYNIAVGNQPHSEVAALAVFLDRLFEGSELEKKFSGGKMRVLPSKSGKKVEKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB26</accession>
    <name>A0A133VB26_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000063">
        <property type="protein sequence ID" value="KXB03615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03615">
        <property type="protein sequence ID" value="KXB03615"/>
        <property type="gene ID" value="AKJ48_03725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="217" mass="24728" checksum="FE2007502E7BB829" modified="2016-07-06" version="1">MIGEWPILPRSPLAPASRGGCFKGGGGHTRVVGKAMKRKKAEELLREAFEEYQGDPRNWAFWVSTEPSRPEVYLIHGGEAYFLKVDSIYTPKPVGVGTKFRVEEDQLSGRLPESGFRRLSRRDLEEIFSGVPRPEELESGEELERAARLVHKRLRERVSGKRPIPFGPPEPGDEAFAVGPYAFGDPLEYVSGEQRRLKRELARELERLERMRHPEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VB38</accession>
    <name>A0A133VB38_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N6_Mtase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000063">
        <property type="protein sequence ID" value="KXB03614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03614">
        <property type="protein sequence ID" value="KXB03614"/>
        <property type="gene ID" value="AKJ48_03720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.734"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="347"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="796" mass="92707" checksum="2F9EB82B4FEBD3AB" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBV5</accession>
    <name>A0A133VBV5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000056">
        <property type="protein sequence ID" value="KXB03929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03929">
        <property type="protein sequence ID" value="KXB03929"/>
        <property type="gene ID" value="AKJ48_03585"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.684"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="PTHR11093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="65"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB03929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="459" mass="50616" checksum="F27184F9607FF5A7" modified="2016-07-06" version="1">MPEIEEVSEEEAGRFERISAHTHIRGLGLKEDGTARDIGDGMVGQKKAREAAGRVVELVKKGKLGGRLILFAGPPGTGKTALAVAIARELGGREVPFVNLSGSEIYSSEKKKTEILTESLRKALGVRLHEKREVYEGEVKSLDIKTGQTGLNPYQQAPSEARITLGTKKEEKTLRLGRSVAASLQSQQVEEGSIIQIDAESGRVINLGVSRDAWEEEKKADISVSPELVDVPTGPIMREREFVSTLNIHQIDSVAAARSAGGLSLFFGGGGTEITDEIRQRTNEQIRAWIEEGKGELLPGVLFMDEVHMLDIEAFSFLNRATEEEFSPITIMASNRGLTKIRGTDYESPHGMPLDSLDRLLIIDTHPYNKGEIKSILKIRAREEDAELGEEALDFLSDVGEKTSMRYAVQLIAPANEVAESRGRKKITREDAEEARRLFISVGDSVEFLKKYEEKMMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC56</accession>
    <name>A0A133VC56_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000052">
        <property type="protein sequence ID" value="KXB04036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04036">
        <property type="protein sequence ID" value="KXB04036"/>
        <property type="gene ID" value="AKJ48_03455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="258" mass="29921" checksum="87300B86FE17A684" modified="2016-07-06" version="1">MLNFMGKRQVVRDGFNKRKTMPDIQMLECNNCKRDFCLRAGTIFYWKHASMGELFIVTWIFFGQGSRRWTREWIRKLGKFCCSEWFQRLEKKLVEHVGDSSRFLNGFFQADEMYINSFGEKLLVFGVKRGDGKIFETVLRGHSAFEFASALKKADEEVGPIIDLDTDAHTSYPLATEWLGILHRPVNRSEEGFVNEKGVHSNGVENLWSHDRAWIEAARGYGSMETLKRAVKAHQVFHNQIKESPVPVWSFLRMLSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC87</accession>
    <name>A0A133VC87_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000051">
        <property type="protein sequence ID" value="KXB04058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04058">
        <property type="protein sequence ID" value="KXB04058"/>
        <property type="gene ID" value="AKJ48_03415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="190" mass="21546" checksum="18B4E94D60C61E2B" modified="2016-07-06" version="1">MLSILEKLNQLKRTLRMGWLESGIPPSEAEDVAQHSFETTSITILIGDQLQRKGVEINLGRAIEMAVIHDWSEAIMGDLSREVSLELGEEIKNDLEEESLEELVGELPDGEKYLELWREYLGGESIEARLVKSADLLSILVELINYRDRGWGNEQLNEIWDNVRGELATYGEEFAPVGELLVELDGRYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCG7</accession>
    <name>A0A133VCG7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0216 protein AKJ48_03335</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0216 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000048">
        <property type="protein sequence ID" value="KXB04146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04146">
        <property type="protein sequence ID" value="KXB04146"/>
        <property type="gene ID" value="AKJ48_03335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00585">
        <property type="entry name" value="UPF0216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002746">
        <property type="entry name" value="UPF0216"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01886">
        <property type="entry name" value="DUF61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005264">
        <property type="entry name" value="UCP005264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="138" mass="16220" checksum="2A7674EBCC64C6A0" modified="2016-07-06" version="1">MKEDRFLRKQIQTLNRHLPKRRASLAKLLKEEKPQVTARDKTTHRFKKQELKYLAELLPKDLHKRLRLPIIIRISPQLGRGAAKISGKIERTVIEKILEKEKSEEDELVIYRPEVRIVRKKLPTTTQYAFMISTGAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCK2</accession>
    <name>A0A133VCK2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000047">
        <property type="protein sequence ID" value="KXB04179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04179">
        <property type="protein sequence ID" value="KXB04179"/>
        <property type="gene ID" value="AKJ48_03295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="161" mass="18038" checksum="0BCF9A563030067D" modified="2016-07-06" version="1">MSFRRDQRGFIFSLDATLAVLVALIVLAGVASVGSSSTTYKQHGYLRLERYANDALEVMELTGTTDNIKSLLDQGENSKAESLAENELRKILPNEVQFKLRIGPEDDPRLDNVYPSPRNHEEWRAAFENAEEIAVATRVLVFSPENVVDSINLYVWRGPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCL6</accession>
    <name>A0A133VCL6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_03275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000047">
        <property type="protein sequence ID" value="KXB04175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04175">
        <property type="protein sequence ID" value="KXB04175"/>
        <property type="gene ID" value="AKJ48_03275"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.590"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009639">
        <property type="entry name" value="Pept_A24A_C_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06819">
        <property type="entry name" value="Arc_PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Arc_PepC" evidence="3">
        <location>
            <begin position="135"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="259" mass="28403" checksum="969EF6F6EDC170F9" modified="2016-07-06" version="1">MWLELIPAGLALGAVIIANYTDLKDRIIPNKLTFSLIGFGIVFYLAFGISSGEFVRAFYGVIGASIAFGIGYVMWLTGGWAGGDVKLFTALGALLPAYEAPYLAPPYSVNYPLFPLTILFNGIIAAIPFLLIYVAVSRAMGRGAFYETVKISELKEGMIPAEIIYEKNGKIKRYDSGYFGFLSRAFGTPEWDRQLANPDRAAGISRYYVGVLRRMVREGKLKDRIKIKKGMPFAPALGAGVFIGIFYGGLYWGLLTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCM5</accession>
    <name>A0A133VCM5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000047">
        <property type="protein sequence ID" value="KXB04181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04181">
        <property type="protein sequence ID" value="KXB04181"/>
        <property type="gene ID" value="AKJ48_03305"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.597"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="92" mass="9885" checksum="E0B0D6B78B5C2190" modified="2016-07-06" version="1" fragment="single">NTNETVNARAAARDGVQSAITKLAIQYGVDIDISAHDMDGDNIIFYLTVQGNPPPDNNSIIEAAKDAAENQLEQVGAGDYEVTIIIDRRVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCN3</accession>
    <name>A0A133VCN3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000047">
        <property type="protein sequence ID" value="KXB04177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04177">
        <property type="protein sequence ID" value="KXB04177"/>
        <property type="gene ID" value="AKJ48_03285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018663">
        <property type="entry name" value="DUF2101_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09874">
        <property type="entry name" value="DUF2101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="261" mass="29469" checksum="969FE09295376931" modified="2016-07-06" version="1">MVGKMTSKGSKLADFFRKIGEAILSVRKLPSKLKWGTSDLKEKIRVKKKSKAKPTVPKILQGFFEQRHAGWPEYVILKVQICVIILFAISAIFAIFPGWTPEVVFIPLILILVGYTLYLVPTQLKRAFKQDYPAYRAFIGIILIIVFVLVVVLRYISFGIVESPQMALVPVILVIGSILGAFAAFRVKYGRNYTYGVVQRVRDSKAAVRITYDIRSNVKHGLHFLETLVKVKSGDRVKVGVERSMWGLRGSEPTTILERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCU6</accession>
    <name>A0A133VCU6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP_bind_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000044">
        <property type="protein sequence ID" value="KXB04278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04278">
        <property type="protein sequence ID" value="KXB04278"/>
        <property type="gene ID" value="AKJ48_03190"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.569"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00269">
        <property type="entry name" value="TIGR00269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="315" mass="35497" checksum="C927EBE56A81CDBC" modified="2016-07-06" version="1">MQKCSFCGRRPVIHQRYSGVYRCDRCLIESVEKRFRHTIADKDMISPGDKVIVAVSGGKDSVALMHLLANYSTHKNVELAVLTIDEGISGYRDESLKLAREGSKELGLKHVVVSFEEAFGETLDQMAASLNETGKPDTCTYCGILRRSLLNQAARELGADKLATAHNLDDEVQTIMLNYIRGDLARLSRFDVNPPGREEFVPRIKPLRNIPEKEITIYALLKDFEAQIAECSYISGLRTNVRDFVNELEASHPTTKFKILRMFEKLKPHLPDVSEGFELKECKICGEPTPEGLCRPCELLEQLGLGRRKKKIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCY6</accession>
    <name>A0A133VCY6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000044">
        <property type="protein sequence ID" value="KXB04277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04277">
        <property type="protein sequence ID" value="KXB04277"/>
        <property type="gene ID" value="AKJ48_03185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="70"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="272" mass="31034" checksum="31B1B3352F694C9A" modified="2016-07-06" version="1">MNPILERVPALQNIRGEPIIAVTNGRKHNFRDIPTKHVKETFEKASYFYVARSPHKVRLPEYPEPKLLHLVGYHAGDGHLEDVEKTVQRRGRGHYEISYSDCCGEMLHKVLGPAFEKLFNISLRLSKRPREKTYIGRVESKVIHTFLNRVIGLPTGSTKPVVPKWIRRGNKDLTTHFLRGFFDAEGSIFSDSYDGTVRISTSSSSLTILKQIYLMLQKCGISFCKPYMKHKQQALEIKTGRSVTIQRFAKRIGFTHPAKAAKLENMLDSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCZ0</accession>
    <name>A0A133VCZ0_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000040">
        <property type="protein sequence ID" value="KXB04312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04312">
        <property type="protein sequence ID" value="KXB04312"/>
        <property type="gene ID" value="AKJ48_02985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="316" mass="35663" checksum="EC5DBDFD94992857" modified="2016-07-06" version="1">MERVLVTGAGGFIGSHMAKYLKDKGHWVRGVDIKEPEFIENPANEFEVMDLRDKGNCLNATKDVDSVFSFAANMGGIGFITKVKADVMHDNVLINTNMLKACVENDVERFFFASSACIYPHELQEDASKIAYLKEKEAYPASPGTPYGWEKLFTEIMCESFTEDYGLETRMARYHNIYGPYGTYKGGREKAPAALSRKVAMAEDGDSITIWGDGKQIRSFLYIDDCMEATYRLMQSDHKEPLNIGSDEAISINRLADLIIEISGKDIEKEYDTSKPQGVRSRNADLTLIKQALDWKPTVSYEQGLEETYSWIEQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD12</accession>
    <name>A0A133VD12_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ORF">AKJ48_02970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04332">
        <property type="protein sequence ID" value="KXB04332"/>
        <property type="gene ID" value="AKJ48_02970"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.505"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="394" mass="42825" checksum="75B5145016832DD6" modified="2016-07-06" version="1">MKFDPDSAKKLIAHTYKRQPLALVEGEGVKVEDDEGKEYLDFVGGIAVCALGHSHPNVAKAICGQSKKLAHVSNLYHIPPQVELAGKLAEITPKGIEKFFFCNSGAEAVESAFKLAVKHTGRGKIVAFEGSFHGRTAATVGATWNKSYREPFEALIPPIFEFAPFGDLKGVKDTVDEDTAAIIVEPIQGEGGVNVPSDDFLPRLREICDENNALLIADEVQAGMGRTGKWFACENWEVEPDIITMAKALGNGFPIGCMGAKSEVMDSFSPGDHASTFGGNPLACTVGKTVIETMEDEKLLQRAAKVGEYFKEKLEDLASKHDACIEARGLGLMLALELREEDVAKSVLSRAREEGFLINRTAGSVLRFVPPLIIKQEHIDELINTLDKILEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD19</accession>
    <name>A0A133VD19_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo3</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo3</name>
        <name evidence="4" type="synonym">rpoD</name>
        <name evidence="6" type="ORF">AKJ48_03065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="4">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000042">
        <property type="protein sequence ID" value="KXB04294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04294">
        <property type="protein sequence ID" value="KXB04294"/>
        <property type="gene ID" value="AKJ48_03065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="261" mass="28806" checksum="A10D5ACD2516441F" modified="2016-07-06" version="1">MGIEIRELEGDTMRILITDTNPAFANSIRRAILQEIPVMAVDEVDVAANDSVMNDEILVHRLGQVPLHTPDGYRLPRECDCTDGRCPKCSVTLTLEKEGPGIIKTGDLESSDEEVVPVSDSIPLTRLDEGQNLEFTAIARLGFGKDHANWQPAVVAYKFMPIFELDEDACTACGDCIDACPKNILEIEDDEVKITNIEKCTMCLACIDSCPEDAINIDHDPTKVILKIESTGAMPPDQLLEKATEVLEDKCKEFAKKTKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD33</accession>
    <name>A0A133VD33_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04366">
        <property type="protein sequence ID" value="KXB04366"/>
        <property type="gene ID" value="AKJ48_02855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="275" mass="29390" checksum="B4973573C82A3518" modified="2016-07-06" version="1">MTSFENLKIVTRYELLKQVRRKRFYGALVITVLAVVLMIGLYHGLDLPEKIGISEGVMSQYETEIFAMFVTSMGSLAVLAAVFFAGDSIASEFEHKTGYILFNNPVKRSTIVIGKYLACLIATSVILIIGFIISGISIMGFYGEIPFGILGSLGMGAMLACSVIGISFAFSSYLNGGMGATIATILFFMVISPIISSSLAYAGYSPWFMLDRAADAMVSTYGVPLDVMAGGFGGGPMGGMTEASSDTSLSFLALTAYAIISFVISLILTERREVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD34</accession>
    <name>A0A133VD34_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000037">
        <property type="protein sequence ID" value="KXB04350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04350">
        <property type="protein sequence ID" value="KXB04350"/>
        <property type="gene ID" value="AKJ48_02885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="121" mass="13813" checksum="37DDDE1E97295E61" modified="2016-07-06" version="1">MVYAMPKKSDSRIEEVHTCLDPVVVEALDRMVSDGLYSNRSEAVHDVLENVFSHSSNKETEKSCFLCNEQSGDIQSHHLVPKFMTEFFSELNWQGRYYRPVPSLPRKASLPLGANPLRTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD60</accession>
    <name>A0A133VD60_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rrp42</name>
        <name evidence="5" type="ORF">AKJ48_02805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04383">
        <property type="protein sequence ID" value="KXB04383"/>
        <property type="gene ID" value="AKJ48_02805"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.464"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="3">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="4">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="257" mass="28490" checksum="D34EFFE3E660A0F1" modified="2016-07-06" version="1">MTQEEIVASVKRDYIFNLAQQNKRTDARALDQYREISVEPGWAGNAEGSALVKIGNTQVLAGVKLEKGTPYPDKPESGVLTTTAELVPIAHPTFEPGPPGEETVELARVTDRGIRESEMIDLDKLCIEPEEEVWMVYIDIYVLDHDGNLLDASALASAAALWNVEISEDLEDWTLPSFPISKKPISTTLAKVNGKLMVDPSFNEESVMDARITISTLENGDICAMQKGGSGPLTRKDLRQAREWARTKSEELRKYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD63</accession>
    <name>A0A133VD63_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribosomal protein L43e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl37ae</name>
        <name evidence="3" type="ORF">AKJ48_02800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04382">
        <property type="protein sequence ID" value="KXB04382"/>
        <property type="gene ID" value="AKJ48_02800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="93" mass="10578" checksum="F1A162AB8604C6AE" modified="2016-07-06" version="1">MPEEERKKKVGSAARFGPRYGTKIRKRVQAIEKEQKKPHECPNCGAKKVKRISSGIWKCTRCNVKFAAKAYSPKTREIEPSALESIESAEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD77</accession>
    <name>A0A133VD77_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000033">
        <property type="protein sequence ID" value="KXB04403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04403">
        <property type="protein sequence ID" value="KXB04403"/>
        <property type="gene ID" value="AKJ48_02670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="117" mass="13513" checksum="8067285AC6220EEA" modified="2016-07-06" version="1" fragment="single">MVKSLIELGQLAEEEGIAFHVENNTAFDKVFVEPEELIDVVEEVRGQDVEIYFNFDIGHWFTRADQGKEISMPPEEVMNKIPGEMVKELARRLMEINPKLLDSFEGEVIDPYKTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC5</accession>
    <name>A0A133VDC5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000033">
        <property type="protein sequence ID" value="KXB04404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04404">
        <property type="protein sequence ID" value="KXB04404"/>
        <property type="gene ID" value="AKJ48_02675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="133" mass="14759" checksum="F311D1F148180CC2" modified="2016-07-06" version="1">MRLGRNFTNLLYPDYLNEDNREKVLAGEMAVHDMDALVQVKEKADISGQIRAAEEMGVDHVELDGAVPNPYLEFTEKQKGEAKDAEASSDVTLSFHLPYTYVADLCSGVHVRSSRARPTNCHGTSKAILEVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC9</accession>
    <name>A0A133VDC9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMC_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_02605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000031">
        <property type="protein sequence ID" value="KXB04431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04431">
        <property type="protein sequence ID" value="KXB04431"/>
        <property type="gene ID" value="AKJ48_02605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027131">
        <property type="entry name" value="SMC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="PTHR45916"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="5">
        <location>
            <begin position="29"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="190"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="347"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="461"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="657" mass="76355" checksum="6888978543568479" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDH3</accession>
    <name>A0A133VDH3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl19e</name>
        <name evidence="9" type="ORF">AKJ48_02435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04485">
        <property type="protein sequence ID" value="KXB04485"/>
        <property type="gene ID" value="AKJ48_02435"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.350"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01418">
        <property type="entry name" value="Ribosomal_L19e_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_L19/L19e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033936">
        <property type="entry name" value="Ribosomal_L19e_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015973">
        <property type="entry name" value="Ribosomal_L19e_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015974">
        <property type="entry name" value="Ribosomal_L19e_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="8">
        <location>
            <begin position="2"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="149" mass="17136" checksum="EC8E5BD29AE84A09" modified="2016-07-06" version="1">MNLKTQKRLAADILGVGENRVWIDPDRVTEVSTAITRADIRSLIKDDAIKAKPKKSTSKARVRKHQKQVQKGLRKGSGSRKGAKGARTPKKEAWKKRVRALRRRLRELRDQGTIDSSRYRKLYRMVEGGSFRSKAHLESYLKKRGILEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDI6</accession>
    <name>A0A133VDI6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000028">
        <property type="protein sequence ID" value="KXB04477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04477">
        <property type="protein sequence ID" value="KXB04477"/>
        <property type="gene ID" value="AKJ48_02390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="72" mass="8058" checksum="9D949826E9A13A80" modified="2016-07-06" version="1" fragment="single">MVTITVSGLHGVGKTTTAKKLAEKFDLRYVSAGTVFRQMAEEQGMTLEEFSKHVEENPEIDEEIDQRTAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDM4</accession>
    <name>A0A133VDM4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_02385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000027">
        <property type="protein sequence ID" value="KXB04504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04504">
        <property type="protein sequence ID" value="KXB04504"/>
        <property type="gene ID" value="AKJ48_02385"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.340"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="549" mass="59373" checksum="49133BA8D1FB6921" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDM7</accession>
    <name>A0A133VDM7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000025">
        <property type="protein sequence ID" value="KXB04531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04531">
        <property type="protein sequence ID" value="KXB04531"/>
        <property type="gene ID" value="AKJ48_02295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="349" mass="39476" checksum="243FD968952D10AE" modified="2016-07-06" version="1">MSESDSQTILTPQHHEDCVLRKSIQFKNLVKTERGEVVSVRPCASEKGKIMAEIELPTRKDELFLDSQLLCRLLRAYKRRFTKMKCSSKLGVGRVMWKARRTYIYKHGKFDVRFALSQDDALKTMDSIGRLILGSIFCKKCGQPAIECALGQCEECVSNNLQSVTLDELSTPLFIKGFEALTEALEISRVTLIETSEIRPISPSQVSKFKSKIQEGVEFFLDSSLKTPEWTNVSASVSSVSLAFSIEDFHEKAVELTEALAKRPGGREEDIQSIRQFEKLALETFKILLEAFHNDDPDRLKLVKQKNSELSELLEELDSNLSGNILGRIREMYEDASSVWSGLLKSYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDN4</accession>
    <name>A0A133VDN4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_02330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04514">
        <property type="protein sequence ID" value="KXB04514"/>
        <property type="gene ID" value="AKJ48_02330"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.329"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="9"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="186" mass="20004" checksum="A5957A28617BB4C5" modified="2016-07-06" version="1">MSEKEEITTLSPPLSEEEVKELKAGDMVKITGTIITARDKAYARILEFSRAGKELPADLEGGVVYHCGPLVKKTDDEWEIISAGPTTSARLDDVQTEFVENTGVRVLIGKGGMSQKVAEEVGELGCIYLAFTGGAGALAADAITSIEDLVWEDLGTAEGIWVLKVKEFGPLLVAIDMKGGNLYEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDP7</accession>
    <name>A0A133VDP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04576">
        <property type="protein sequence ID" value="KXB04576"/>
        <property type="gene ID" value="AKJ48_02130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="64" mass="7774" checksum="22216D0F3CAE3177" modified="2016-07-06" version="1">MNYRELKELARRVDQSEGEERERLLRKLIEELPELDPFEGHSEFAVMVAKMLAGVKWFPYWRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDQ1</accession>
    <name>A0A133VDQ1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04572">
        <property type="protein sequence ID" value="KXB04572"/>
        <property type="gene ID" value="AKJ48_02100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="96" mass="10700" checksum="65F39CB0F0CDDE0D" modified="2016-07-06" version="1">MGSWQRKALIALFYPFTLLMIVAGFTAFVLLVFDFSTFFAATVALCFFSFSATILYLIFRPVIKLLDVRWIFLGLVVAADVLAILSLGTLLLRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDR9</accession>
    <name>A0A133VDR9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000021">
        <property type="protein sequence ID" value="KXB04598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04598">
        <property type="protein sequence ID" value="KXB04598"/>
        <property type="gene ID" value="AKJ48_02075"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="6">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="5">
        <location>
            <begin position="149"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="257" mass="28572" checksum="BD0F59C5CA3F9811" modified="2016-07-06" version="1" fragment="single">MENDFKCLSYTFREGPVQDIPSVGREIKKFIDRKNIESHVFIQTCNRAEAYFFSNSLENSIPDKAILREGKEALNHLLEVTAGVDSLIVGETEILSQVREAFKNSVRKNQIGPKLKGVFDWALEFGKKVRRETEISTGKVSVASIGLDHAQDILKEFTGKKAIIIGAGKIGTTAARFLKDAGIGSIFVANRTYERAVELSKEVGGESYRLSRFPELLPEVEIIICATSAPHYILTEDKIPELSEKKVLLDLSVPTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDT1</accession>
    <name>A0A133VDT1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04608">
        <property type="protein sequence ID" value="KXB04608"/>
        <property type="gene ID" value="AKJ48_01980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="408" mass="46227" checksum="98063189F1441260" modified="2016-07-06" version="1">MIKDVTQVPREELLELAEERIFSLGLRDLASVLAYENMRYALGRMIYALENDDVYCVLAPDATITRNKPRWLSGYGYGGVIRWSDENVAFPEIRPNACGMLLMRLDNLPSKKDLVKRASEVEEKELELNGVKINPDFGRGNHFFELYKPLEISEEVSDVLPPDAFYAVLHSSAPELKDKMYSWAEKGEKVNTPLGYITILKNSAAREYYKDWEKLKEFSKRRRELLAREVVGEHEVVSNFIHQGLFAPNEARLGCYNTTEQEEDGLFPVALRWDFPVHVLRGKPNLSDEVIHRLEFQERAERLGLEEELRNVNTLPHGGGYKIQLPYQKIDITTTSFGNVFTLSGLKPASTMSEISEGKAISEFGGMAITDPHSLPYTYRGEAVIGKTIDLGLGDPVAKLRPVLTVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDT6</accession>
    <name>A0A133VDT6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="2">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-IPM isomerase</fullName>
            <shortName evidence="2">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">leuD</name>
        <name evidence="4" type="ORF">AKJ48_02010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000020">
        <property type="protein sequence ID" value="KXB04613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04613">
        <property type="protein sequence ID" value="KXB04613"/>
        <property type="gene ID" value="AKJ48_02010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.229"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="3">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="169" mass="18635" checksum="3746039BD1FC7BC6" modified="2016-07-06" version="1">MKKIKGKVWKFDDDISTDLIISGKYKFKTLDMGELSKHAMEGADPDFAENVGKGDIIVAGENFGCGSSREQAPLVLKELGVGAIISKFFARIFYRNAINVGIPVIENEEIPDKTSAGDQLEVDLTAGTVENLTTGEKFEVKPLPEFLLKIIEKGGLVEQYKKQGKLPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDW8</accession>
    <name>A0A133VDW8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_02070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000021">
        <property type="protein sequence ID" value="KXB04597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04597">
        <property type="protein sequence ID" value="KXB04597"/>
        <property type="gene ID" value="AKJ48_02070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="142"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="4">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="3">
        <location>
            <begin position="421"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="539" mass="60142" checksum="184D62D4E9D7A042" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDZ4</accession>
    <name>A0A133VDZ4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="6">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aspC</name>
        <name evidence="6" type="synonym">aspS</name>
        <name evidence="8" type="ORF">AKJ48_01830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04673">
        <property type="protein sequence ID" value="KXB04673"/>
        <property type="gene ID" value="AKJ48_01830"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.196"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="145"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="439" mass="49850" checksum="449F2FF61E28D098" modified="2016-07-06" version="1">MKPKNLGKWRRTHLSQEIDSDLAGEKTTIMGWVTDIRDLGGIKFFILQDFSGTIQVTAPKAKVGKDILNEIDSISKESAVAVKGEIAKADQAPRGVEVVPSEIRVLNPAETPLPLDPTGRVKADLDTRLDARLLDLRRPKPQAIFKIKHGAVQVIRNHLTSEGFVEVYTPKIVRSATETGATLFPISYFEKEAFLSQSPQLYKEVLTGCLDKVFELGPIFRAEEHDTRYHLNEVISADIEVAFSTKEDVIDILEDLIVNIFEEITEDHEEELETLEHEIEVPEKPVPRITYDEALEKLNDAGMKLEWGADFSIPEQRKLREIVGGLFFITDWPTEIKPFYIMPHEDDSKLSHAFDLLYNEIELASGGTRIHQRGLLEKQLKNKGLNPKRFEYHLKNFEWGLPPHSGWGLGVERLTMALTGAENIRETVLFPRDRKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE00</accession>
    <name>A0A133VE00_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04670">
        <property type="protein sequence ID" value="KXB04670"/>
        <property type="gene ID" value="AKJ48_01810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="133" mass="15436" checksum="629759B0292375E8" modified="2016-07-06" version="1">MEPKDEVNKVEEWIEENPLARVLLEKSGLDKGVLKTLLLYYWSEDVTFEGLAQRLDLKKPGAWKRWRKGLDTIIQSFYTIELAVYSGILDAETAKLLAEDLQDYVELTEEEGDLEAIRDRLEKRMVELKGQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE09</accession>
    <name>A0A133VE09_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04688">
        <property type="protein sequence ID" value="KXB04688"/>
        <property type="gene ID" value="AKJ48_01710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="15"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="441" mass="48496" checksum="C1EFAD5248C07D6D" modified="2016-07-06" version="1">MTIEIMPLGGLGEIGKNMMTLRFDDVNLIVDMGIKLENILGLDDSDIGKMSREKLIEIGGIPNDSKFRTRDVSAILLTHGHLDHIGAIGKLAHEYEAPIYATPFTTELARHVVKDERVFDVKNELTPIENGESIEVDGVEIEFIRGTHSIPQTALPAIHSSEGTVLCAVEFKLDENPLIGGSTDYERLSQLSNDDLLISLVCAVRADEPNPTPSEAYAKKILMEKMTEASDRGKGLFVTCFSTHIARIKSIVEISHKIERKPIILGRSIKRQCRIAIELGIVDLPSDLVMCGRSGSVQNALKEIKDSRENYTVIATGHQGEPNATLSRIADNRTPFKIQDEDEVIFSASVIPNPLNEANRDLLEAKLEAQGARIHRDVHVSGHAGQPGTRELIEVVNPDHIIPVHGTPEKLDAVTNIGRKMGYSSDQLHLLENGESLELNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE17</accession>
    <name>A0A133VE17_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Isopentenyl phosphate kinase</fullName>
            <shortName evidence="10">IPK</shortName>
            <ecNumber evidence="3 10">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">AKJ48_01700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3 10"/>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04698">
        <property type="protein sequence ID" value="KXB04698"/>
        <property type="gene ID" value="AKJ48_01700"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.168"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04241">
        <property type="entry name" value="AAK_FomA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="13">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="7"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="177"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB04698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="262" mass="28151" checksum="8E562170FFCBEE3B" modified="2016-07-06" version="1">MKPLIVKLGGSIITDKSKEFTVREDALNRLAEELTSVEGPLIVVHGGGSFGHPLASKYGINSGYENKSQLMGFALTHRAMEELNSAVVSTLQDASIPAVPIQPSACVIVENGEISSIEVSSIRKLLELGLVPVMYGDAVPDLERGMSILSGDQLVVFLARELGVERVILGVDTDGVYTGDPKKDEEAELLPKITPKNWQEIKDSLSTGAAPDVTGGMRRKVEELLKLPEIGIEAQIINASKPKTLKKAIKGDKSLGTRIIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE21</accession>
    <name>A0A133VE21_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="7">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltX</name>
        <name evidence="13" type="ORF">AKJ48_01720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04690">
        <property type="protein sequence ID" value="KXB04690"/>
        <property type="gene ID" value="AKJ48_01720"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.172"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="99"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="12">
        <location>
            <begin position="405"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KXB04690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="563" mass="65000" checksum="CFF3C79D3AD0F37D" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE55</accession>
    <name>A0A133VE55_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04732">
        <property type="protein sequence ID" value="KXB04732"/>
        <property type="gene ID" value="AKJ48_01555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="101" mass="11328" checksum="B9CE9E0E5042F091" modified="2016-07-06" version="1">MILAYPSNNSLPASLEPFAFLRDEDLPVRISYTELRPPRALGFAFIFGFAEALAFQIMVLSGIKEIVPYQFILMIPYITTLVAVAIVGRAMSPQSHRQVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE62</accession>
    <name>A0A133VE62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04743">
        <property type="protein sequence ID" value="KXB04743"/>
        <property type="gene ID" value="AKJ48_01605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="224" mass="25889" checksum="866ED35F019C6236" modified="2016-07-06" version="1">MSLNKTNGNMYPWVTHTWNPLAGRCQHGCRYCYMKKGFLGNLEKYKGKVELVEEELNTNLGSDKTIFVGSAIDLFGDWVPESAIRKILSSCGEFSNTYLFQSKNPARFTNFLDLLPESTILGTTLETNREYNISQAPEPPQRYQDFLAIDWPRKMISIEPIMDFDLDKFVKWIKRIDLEFVSIGADSKNNGLREPSSDKVRNMIKKVQEFTEIRAKKNLNRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE70</accession>
    <name>A0A133VE70_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000014">
        <property type="protein sequence ID" value="KXB04731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04731">
        <property type="protein sequence ID" value="KXB04731"/>
        <property type="gene ID" value="AKJ48_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="227" mass="25929" checksum="0DBA59A1F61C0110" modified="2016-07-06" version="1" fragment="single">PPISFPSDMTYPSLSRHCFDFSTLREIRPEKARSLYDKVAEYILELVKVGTELDYVDAIRVADDLCSYVGPNYSREFIETDYLRWHREFARIAQKKEKYSKLHTDGNLLVGGLMKKLSKIYDAIHPLDFMPKITLTDSLKWVDSIVEARSLSGGMIFFTGIPIEVMFREESSPGQIGETVRKLLQEHGRKRLVLSNTHRPYPGRSFNEAGAILKAKIVKEEAGKLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE86</accession>
    <name>A0A133VE86_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04760">
        <property type="protein sequence ID" value="KXB04760"/>
        <property type="gene ID" value="AKJ48_01510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="427" mass="48570" checksum="6E4917C55F5D7884" modified="2016-07-06" version="1">MILLTRAGYAKLLLAIGIMITVNIMPMSWGTASSSDVTVSIYPEEPYNKFYLGNEINVTIEISNIGEATERIKLHLSEYPENMLVIGRDGLALPFERDIAGGEDFYYGVVAIPHDNVDNDLIGFKATTPNDNLLDAKQISLEIIRPQLDNENLAVKASEYGLSEIVRVFSIPRYRRYWHPDRDEKSTNAQLGYVWLIIGTEGNILIDDNTGELIATNVRIPNQADAPEQGTARVWNGNRFENLQVPTVKTVGDLSFTLRRFELYYAEQNGKPVWVTRQILYWQIGEDPIIQAGGPLSETPDTERVELWVSAEDGTELSTISDYHFYSYKYDPTDSYTIAGDVHSPLPSEVGWQMWFSAIANYKNIYPASSIPHDRIGFTKYAHPLTRTFFEEYWLVVRRNLVGLTLVILVFITPIMWKFFKSRTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE87</accession>
    <name>A0A133VE87_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GtrA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_01490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04756">
        <property type="protein sequence ID" value="KXB04756"/>
        <property type="gene ID" value="AKJ48_01490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="147" mass="16676" checksum="E05082B54D75D2ED" modified="2016-07-06" version="1">MKSLREFYKLVDEKLETKRFLKFCMVGLSGVGVNLGLLWILTDHFGIYYLVSAVFSVETSILTNFTLNELWTFSDRVTNRSTRPLLGRLTKFNLISAGGLVINITILWAFTEFLGFYYLISALFGIAGATLWNYFANASVTWKKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE98</accession>
    <name>A0A133VE98_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04755">
        <property type="protein sequence ID" value="KXB04755"/>
        <property type="gene ID" value="AKJ48_01485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="465" mass="52720" checksum="0FA8C994934444F4" modified="2016-07-06" version="1">MTRKKIFIIFFLILGSTVVLLAGLNDMDSNLHLDYVREIQEAGRIPVQHPHLYQSDVSSAPFPYPLGYHLTMAIFPHWVSVYKVLGVLFAGILLILVIKISKLFGYKGGLAIITPLALSLSFSRLSITPHPDMFALMLTLTSTYFTLKYIHEENLLYLALAVGFGFYAGMTRKIAVVTLPFIWLVLWLKFNEKRRNLLKVVIPIVLFTGLGYYLVNPIFRGTDLIYPVQGGSDPSAYNWYMTHLSFWSSLTQGYFMHALGIIIVAFSVFLPLFFTKPQDKTLALVFGGEILVILILMPSTAGLARYVMFTLPFLTIAYGNHFENSKRWIPILFLGALIIYPAQGLYLDSEIPNDFNQITSHLDQNDFVLAREQGQLAYRVGCRAGWTSLFWSGDLYDTFENVDRLENFIATHGVTHVLINKELIVPSDSQMINGEAVGFPQDWVNEIDNIGLKIDETKHYVLYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEA5</accession>
    <name>A0A133VEA5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <shortName evidence="15">FBP A/P</shortName>
            <shortName evidence="15">FBP aldolase/phosphatase</shortName>
            <ecNumber evidence="6 15">3.1.3.11</ecNumber>
            <ecNumber evidence="15">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fbp</name>
        <name evidence="16" type="ORF">AKJ48_01515</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6 15"/>
    <dbReference type="EC" id="4.1.2.13" evidence="15"/>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04761">
        <property type="protein sequence ID" value="KXB04761"/>
        <property type="gene ID" value="AKJ48_01515"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.130"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02067">
        <property type="entry name" value="FBP_aldolase_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="FBP binding" evidence="15">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="FBP binding; shared with dimeric partner" evidence="15">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for FBP phosphatase activity" evidence="15">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for FBP aldolase activity" evidence="15">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DHAP; for FBP aldolase activity" evidence="15">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KXB04761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="364" mass="40360" checksum="78091A0D13384E83" modified="2016-07-06" version="1">MKTTVSVIKADVGSLPGHVKVPQDMLDVCEEALSKAKDDGIVKSYYVTNCGDDINLIMAHDKGVDAEEIHELSWNTFMTAGDLAKERGYYGAGQDLLKEAFSGNVRGMGPGIAEFEIEERPSEPIIVWACDKTAPCAFNLPIFKMFGNPFNTAGLIIDTKMHSGYKFEVHDIKKGRRIFLNCPEEMYDILSLIGIVDRYVIKRVFRKSGEIAASVSTEKLSLIAGEYVGKDDPVAVTRAQSGYPAVGEELEAFAFPHLVPGWMRGSHQGPLMPVSHEDATPTRFDGPPRVMALGFQLKNGELQGPEDLFDDPSFDGARAKAVEIADYMRRHGPFQPHLLPEQELEYTTLPDVIEKMEDRFEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEB7</accession>
    <name>A0A133VEB7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl12p</name>
        <name evidence="4" type="synonym">rpl12</name>
        <name evidence="6" type="ORF">AKJ48_01465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000012">
        <property type="protein sequence ID" value="KXB04786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04786">
        <property type="protein sequence ID" value="KXB04786"/>
        <property type="gene ID" value="AKJ48_01465"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.118"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="104" mass="11045" checksum="4FB5C649498DCC0F" modified="2016-07-06" version="1">MEYVHAALLLHSAGQTVNEDNISKVLEAAGAEVDEARVKALTAALEGVDIDEAIESAVMPAAQPAPAPAEAAEEKPEEEEEKEEEAEEEEEEEEEVAGLGELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEB9</accession>
    <name>A0A133VEB9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04798">
        <property type="protein sequence ID" value="KXB04798"/>
        <property type="gene ID" value="AKJ48_01325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="394" mass="44641" checksum="B75B8B7D346781D9" modified="2016-07-06" version="1" fragment="single">TPKHTLKTLIRAYNSRDVDAYENCFSAWVRSETPVNTFKHFLDVAENWNWKLRGIEEWGVIVNTANTRAWGNVGVRVSGVNQLENNHIIHENGKEEWIGKGENFTQLKACYIRFVNEGNAGENEWKIADRPGLFQPVLHATLDLVSAIENHIKTFYPPDDVGYEITYRSGDRVKGFIYLKGENDRVPFEDIELKLKNGHWNLYPSSWDTTVRSPSENLEITGYSVDKATVGSSEWSEMQEVLVRIAPTVRNWSDYPAFVSSVHIRIENSTHTFTRSYPAGVVSIGLISIGIVPSGRTVRIGYRGGLALIPKWSSGGSKSILRMDELAGKNFRVTLTLKDGEGTTLAKRTFHITFEDLSEKQRNVKLEPSLADLDLSGSTQVNFSREQFFHEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEC5</accession>
    <name>A0A133VEC5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04803">
        <property type="protein sequence ID" value="KXB04803"/>
        <property type="gene ID" value="AKJ48_01350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="84" mass="9305" checksum="BC243FA034A937A5" modified="2016-07-06" version="1">MREAGGRLYSKGAAILKMDAYPGSSVCDFTVEKVYQGNAILKVNGKWRAVLAAEDYDGPRHLIKKGARFKGIAKLYHEDGKFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEE5</accession>
    <name>A0A133VEE5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hist_deacetyl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04809">
        <property type="protein sequence ID" value="KXB04809"/>
        <property type="gene ID" value="AKJ48_01390"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.100"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="20"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="343" mass="37578" checksum="8887374952DC854E" modified="2016-07-06" version="1">MTTGIIYSDRYLDHDLGPSHPEKPDRLKSIVRTLEEEGLWRADDTRLIDPTPCTEEDLKLVHDSDHIKSVKESSAAGTMLDLDTPTQKNTFELALLSAGGTIKAFEQVAEGTLDDAYALVRPPGHHATRSAGGGFCYFNNIAIGIEKLRSEGKIDRAMILDFDAHHGNGTQDIFYGNPNVLYLSFHQDGRTLYPGTGFVNEIGAEDGEGYNINVPFPPGSSDEDYASAIQEIFIPLTEQFKPQIIAVSAGFDAHRQDPLTRLGLSTSAYGWIMKLVREQSEKLCGGRTVLVLEGGYNLDVIGDSNVEVVKALTGKESTSPPSKGPTPQVVEEVKDTLSDYWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-12-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEE9</accession>
    <name>A0A133VEE9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetate--CoA ligase (ADP-forming)</fullName>
            <ecNumber evidence="2">6.2.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + CoA = acetyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15081"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.13" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04830">
        <property type="protein sequence ID" value="KXB04830"/>
        <property type="gene ID" value="AKJ48_01315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="438" mass="47195" checksum="627741A815E24077" modified="2016-07-06" version="1">MSLKKLFKPKSIAVIGASTNPEKIGHQILKNIIDGGYKGDIYPVHPKADEILDLECHSSVTDIKGKVEMAVIVVPAKIVPSIIEECGKKNVKAAIVISSGFSEVGDKGAKLEKELAETAEEAGVRILGPNCQGINNTVQNVCATWPLTTKKGPISIIAQSGTIGAALECWAEEDNIGISKFAMLGNRADIDETKLLEFFSKDRTTDVIALYLEGVKNGRKFFEVAKEASEKKKIVVLKGGRSEKGAEAVLTHTRSLAGEYKVFKSVCKQAGLILVESINELYDVCKGIAGLPKPKGKNTIILTSSGGSGILAADAAEDLDLNLMDLPEKSIKRLKKKLPSECIIQNPIDLTGSATAEMYDEAIKVLARYKDVHSIVIIVGDPMPGISDVIKERFERLTLVPVMLGGGKEEVEEKKKLQEEGIPVFSTPENAMKALSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEF7</accession>
    <name>A0A133VEF7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="11" type="ORF">AKJ48_01400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04811">
        <property type="protein sequence ID" value="KXB04811"/>
        <property type="gene ID" value="AKJ48_01400"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.102"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB04811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="462" mass="52517" checksum="CF30F536DEEE6D4A" modified="2016-07-06" version="1">MMEKLLDKVLKKVKPKKDDQEELREVAEELLEKAGEIIDDKGLDVTPMLVGSAARGTWLKGEKDIDIFLLFPEESPRSKLEERGLELAREIAEGKGTEQFAEHPYLTANIEGFDVDIVPCYDIKNPSKLRSAVDRSPHHQEYVKGQLTPELTDQVLLLKGFLRGIGVYGAELRIHGFSGYLAELLIIHFESFQDLIQNAKKWKEGQIIDFTQEYSTPEDVYRMFPDQPLIVIDPVDHSRNVAAAVSEKNFATFVRACEDLDRNPNEKFFFLKPPDLSKKEIREFMKKRGTKIFTIVFDTPSDLVPDIIYPQLRKTERTLIQRLDRCNFKVLRSGVHSTPKKSVIVLELSVSELPKAYKHQGPPLGVESDSFIQKHIESDQKLAGPFIDSSGNLAFELGREYSNAEEVIRDSLESHNGFGKHVAEAIGEGYELAEGATVTKLIDDELKGFFSRYLTHCLPWYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEG0</accession>
    <name>A0A133VEG0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dUTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04843">
        <property type="protein sequence ID" value="KXB04843"/>
        <property type="gene ID" value="AKJ48_01165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="203" mass="23335" checksum="1BC1653EBCCEFAAE" modified="2016-07-06" version="1">MLLSDRDILQAMDEGSIEINPFEREQLQSNGYDVRVDSTYYELKREVDAFFPFTEEFVENAYEKKKARVKEVNVNGRKARGKFIRLPPHGFILASTIERTKTIKDITASLRCRSSLARTAISIARCAGWGDVGYGGVWTMEIVNHLKVPYYLPVGLRVGQLVFFKTKTPPENPYEGKYSGSREPALPRLYNDKDFEELIEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEK5</accession>
    <name>A0A133VEK5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_01185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04847">
        <property type="protein sequence ID" value="KXB04847"/>
        <property type="gene ID" value="AKJ48_01185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="82" mass="9392" checksum="C50585B3B3ECDCFD" modified="2016-07-06" version="1">MSATKFSGLEVVKALVRNHFQIVGRTGSHVKLRYEHPTDESDIRIVIVPMHDSIDTGTLRSIANQAGARDFQKFKKWIDRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEL1</accession>
    <name>A0A133VEL1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_01235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04854">
        <property type="protein sequence ID" value="KXB04854"/>
        <property type="gene ID" value="AKJ48_01235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="15"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="159" mass="16892" checksum="F63031EC235F1F5F" modified="2016-07-06" version="1">MSPAEFGISWASFLEGDWFRLLSFMFVHVRGEHLITNLVALILVGVMAHELGFSSAKILGVFFSVSILSILPLLLLTPAQFVGASASIYGLLGAGVVELRRRGILPLTLLGLLTLVILASSGADIATLSLLAATLMLAAHTIALFLGAIYQIETSKSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEM4</accession>
    <name>A0A133VEM4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01105</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04875">
        <property type="protein sequence ID" value="KXB04875"/>
        <property type="gene ID" value="AKJ48_01105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="342" mass="37395" checksum="C759D2828A56BA1A" modified="2016-07-06" version="1">MMIGFDWIIDIILSPEVFIPLVFPGLLTVTLTLLGIIWLERKLTAKVQLRYGPLYVTRRLGGILQLLADGIKFLFSEQIIPRTVDKLAFLLGPLLLFTFSILPIIGIPLSASYAAITSDLSLLIVVALLVIGPIFFLMISWASNNKFSSIGGLREGYLIISYEIPIIISILAMAVLYHSLDLIEIAESQSGVWGILVNPLAALVFLIAALIATGGFPYEIGEAESEIVAGYGSEYGSILYATIMGAGYLRQYVMSLLFTIVFLGGWNPVPGFIPNSGIFPGVLIFLKSLLVMGLLVFFRSVYPRYRVDQAVRIGWQKLFVLSMVSIGFPIILVTIGIGGVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEM5</accession>
    <name>A0A133VEM5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glmS</name>
        <name evidence="8" type="ORF">AKJ48_01010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04899">
        <property type="protein sequence ID" value="KXB04899"/>
        <property type="gene ID" value="AKJ48_01010"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.710"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="452"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="603" mass="65435" checksum="5195CF8695BA5455" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEM6</accession>
    <name>A0A133VEM6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">AKJ48_00990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04896">
        <property type="protein sequence ID" value="KXB04896"/>
        <property type="gene ID" value="AKJ48_00990"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.706"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="34"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="248"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="389"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB04896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="627" mass="71211" checksum="9420B18A17F5BB3C" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ5</accession>
    <name>A0A133VEQ5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04897">
        <property type="protein sequence ID" value="KXB04897"/>
        <property type="gene ID" value="AKJ48_00995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="157" mass="17024" checksum="FF66F8E8CF931983" modified="2016-07-06" version="1">MAKIAIQGIGEHPAPVIFVIEKEEPDVSYVLTSDYSYDHVDGEGGFDKSSGEAIADAAEKIGTEVKFMKCDTFDPEEIGEKIGEILGGLDPDDEVIINYTAGSATIKIILGATAVAISRFMENLRIVYAIKYPDGTEKYLDQTEALGKLFTQLNQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-02-10" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEQ8</accession>
    <name>A0A133VEQ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04929">
        <property type="protein sequence ID" value="KXB04929"/>
        <property type="gene ID" value="AKJ48_00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="141" mass="16162" checksum="5A43B03857DBFA6A" modified="2016-07-06" version="1">MNLVKYLDASIPLCPIIEKPGEKVEECERIMKSVETGVERVKTSTFTVAEMFHILLHREKLLRKKVGENLNSFLKCAGLRLVDAEKAFCGEAIELSLDRKVDFVDAHHVLTMQKLGIKEIYSLDPHFDGFRNIDRFEAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VER8</accession>
    <name>A0A133VER8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04917">
        <property type="protein sequence ID" value="KXB04917"/>
        <property type="gene ID" value="AKJ48_00870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="92" mass="10197" checksum="83A676FE837DEB0E" modified="2016-07-06" version="1">MRVKVKLFAIFQELAGKKQVTVSAADVRGLLQKLTTQYGELEGRFFEDSEGRELRGGINIMVNGRNIRFLDGLDTRLKDDDLVAIFPPVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VES1</accession>
    <name>A0A133VES1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Preprotein translocase subunit SecG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Protein transport protein Sec61 subunit beta homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="14" type="ORF">AKJ48_01040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04904">
        <property type="protein sequence ID" value="KXB04904"/>
        <property type="gene ID" value="AKJ48_01040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00751">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KXB04904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="62" mass="6749" checksum="674C635B2C445CD6" modified="2016-07-06" version="1">MARRRRGGEDESMPATGAGLIRYFKEDTHGVKVSPKTIVGIAVGIIILEVLLRFYGTAILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VES2</accession>
    <name>A0A133VES2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Digeranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">DGGGP synthase</shortName>
            <shortName evidence="9">DGGGPS</shortName>
            <ecNumber evidence="9">2.5.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Geranylgeranylglycerol-phosphate geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">AKJ48_00920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18109"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="EC" id="2.5.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.42" evidence="9"/>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04936">
        <property type="protein sequence ID" value="KXB04936"/>
        <property type="gene ID" value="AKJ48_00920"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047295">
        <property type="term" value="F:geranylgeranylglycerol-phosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01286">
        <property type="entry name" value="DGGGP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023547">
        <property type="entry name" value="DGGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="277" mass="29151" checksum="71D0AAEFB3E6A382" modified="2016-07-06" version="1">MKPRAVFKLLRPHNCFFAGIGVLIGAIIASGGIPHFTAGFAFAAAFFVSGAGYAVNDYADRKIDAVNNPKRPIPSGELTPSDALGIARTLFVLGILSSAFINLSCLFLAGFNAALLAYYASDLKRRGLIGNITISYLVGSTFLFGALVIGSLTAAGILAAMAGLSTAGRELIKDVEDIRGDRKSDSKTFPIRYGKKKAVGLAIVLTIGAIILSPLPYLLNIFGWPYLAIVGASIGVFIVGMAIIARRQRKKDAHRASLAYKIAMGLGLLGFLVGAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VES7</accession>
    <name>A0A133VES7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_00890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04935">
        <property type="protein sequence ID" value="KXB04935"/>
        <property type="gene ID" value="AKJ48_00890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="92"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="188" mass="22348" checksum="8C43A27E82A0C4CE" modified="2016-07-06" version="1">MLKEMEHGFRPFEERESFEEEFEDPLEKMMKRFEETPEEFEELIKEEETPSGRIRRYGPFVYGFSYSKRPGEEPEFQEFGNIKPGERGEIEPTPRGEREPLTEVVDMEDKYEVTVEVPGVKKDEIDLSATEDSMEIKTTGERKYRKELFFEDSIDPDKIDANFKYGILYVDVEKKEEEEKEGKKIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VES9</accession>
    <name>A0A133VES9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Formylmethanofuran dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_00810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:19841"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57727"/>
            <dbReference type="ChEBI" id="CHEBI:58151"/>
            <dbReference type="EC" id="1.2.7.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FwdC/FmdC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.12" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04951">
        <property type="protein sequence ID" value="KXB04951"/>
        <property type="gene ID" value="AKJ48_00810"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00640">
        <property type="reaction ID" value="UER00692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018493">
        <property type="term" value="F:formylmethanofuran dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019386">
        <property type="term" value="P:methanogenesis, from carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017550">
        <property type="entry name" value="Formylmethanofuran_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03122">
        <property type="entry name" value="one_C_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXGXG" evidence="5">
        <location>
            <begin position="73"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="274" mass="29834" checksum="08EC35DD49F7E286" modified="2016-07-06" version="1">MIILKPKSRFKTPVEAECISPDIFSKKSLEEIKNLPIYEGNEKKTLKDLFEVKEESEDKDEKTITIQGDVKAVKQIGAEMSSGKIKIEGNAGMHLGREMKGGEIIVQGDADDWAGENMEGGLIRIKGNGCNFIGSTSWGKDVGMKGGIIVIEGNVGHEAGKRMRRGIIAVKGNTGSFAGNLMTGGTILSFGDFGERAGAGMDRGTLVAFNPVELLPTFKYDSTYNPNFLRVLLRELGRYDLPIEGKHITGVYERYSGDLAALGKGEILIWKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VET9</accession>
    <name>A0A133VET9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_00825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000005">
        <property type="protein sequence ID" value="KXB04953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04953">
        <property type="protein sequence ID" value="KXB04953"/>
        <property type="gene ID" value="AKJ48_00825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.531"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020931">
        <property type="entry name" value="MfnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03812">
        <property type="entry name" value="tyr_de_CO2_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="373" mass="41966" checksum="3DC984C629247966" modified="2016-07-06" version="1">MNDLLDKLKKYRERDWSYDSGRIFSSMCTNPLDEALEAHQMYTDVNALDSKIFPSAKRLESEVIRKISALYSSTHAGGYITSGGTEGNIYALWLARKLRDKGEKVIAPISAHYSMQKACDLQQLKLIQTTLNDQYKAEVEDINEQTDKETIAIVATVGTTALGKIDPIREIAEIAEDAGCFLHVDASFGGFVLPFIKNAPPWDFEIESVSSITSDPHKMGLTPIPSGVLLVRNHSWIDELRMDIPYLDQTSATLLGTRPGASIASTWMALNLLDSNNYGRIVRRCMKLTRQLAEGIRGISDLRLVTEPELNLVSFTSNTSDVSQLRVALERRRWLVSLNSQPESVRLVVMPHHREEHIRSFLNDLRECVRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEW2</accession>
    <name>A0A133VEW2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0107 protein AKJ48_00600</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_00600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04981">
        <property type="protein sequence ID" value="KXB04981"/>
        <property type="gene ID" value="AKJ48_00600"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.385"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00078">
        <property type="entry name" value="UPF0107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020794">
        <property type="entry name" value="AcnX_sub2_archaea_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012016">
        <property type="entry name" value="AcnX_sub2_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="3">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="132" mass="13905" checksum="B0290B5FD582218E" modified="2016-07-06" version="1">MKLHGCVVKEGEGKGRALVSDKPISFLGGLDPKTGKITEPDHDLEGGSVKDRILVFPHGKGSTVGSYVLYQLAQNGNAPAGIINREAEPIVAVGAIISEIPMVHKLDKDPIKSIKTGDLVIIKGESVLVEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX3</accession>
    <name>A0A133VEX3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_00630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04985">
        <property type="protein sequence ID" value="KXB04985"/>
        <property type="gene ID" value="AKJ48_00630"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.391"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="263" mass="29832" checksum="441EB1254550F5D8" modified="2016-07-06" version="1">MELLLENLSELKDKLTQPPFIITDYDGTLTPIAKRPKDARLSQDMREILSQLAECYPVAIVSGRALENIRRTVRVNNVYYVGNHGFEISGPEMKFVKEEAEQARPIMSKLCEDIKKKVGLIKGVIIEDKGLTASIHYRLVQEEEVPKVKKIVQDSIKPYQEEGTVKALHGRKVFEIGPNIDWDKGKAILWLLESTGLENKNLPIYLGDDVTDEDAFRALKGRGWGILVSEEDRKTEAEYQLKNVGEVKTFLKHLIELSRAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEX4</accession>
    <name>A0A133VEX4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AcnX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04980">
        <property type="protein sequence ID" value="KXB04980"/>
        <property type="gene ID" value="AKJ48_00595"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.384"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01355">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="AcnX_catalytic_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="390" mass="42124" checksum="FD560C839FC1B77E" modified="2016-07-06" version="1">MHLTKNQEKMLSGEEGPALQKAMEILVALGDIYDADGLIPIHSAHVSGISLRTSGEAGLKFVENLADKGAEVYAHTTINPTGIDLESWEELGAPKDLVDKQRRMIDAYERMGAEPICSCVPYLTGNRPSFGKHLAWAESSAVVFANSVLGARTNREGAPSALASALTGLTPLHGYHLDENRQGTVEIEPNLELLQGEETFPYSVLGYWIGENFPESVPVLKGVKPNPAQLKAMGAGMAASGAIALYHIPDVTPEAEADPSICEVGESAGFESSDFEDVVDKLDQISEADLVCVGCPHFSLEELEKMPDSVEGETWVCLPRKLKRESDEKGLSKKFEGKKIRFVCDTCMVVAPLREMGYSSIGVNSAKAAHYAPMLAGVKVHFAPLKELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEZ2</accession>
    <name>A0A133VEZ2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="8">SRP54</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">srp54</name>
        <name evidence="10" type="ORF">AKJ48_00640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04987">
        <property type="protein sequence ID" value="KXB04987"/>
        <property type="gene ID" value="AKJ48_00640"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.393"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="451" mass="50108" checksum="8882C893A4BE0538" modified="2016-07-06" version="1">MVLDKLGRSLHSALTKITKAGRIDEKAVKSLVKDIQRSLLQADVKVQLVLDLTKRIEKRALEEEIPKGVSRKEHLIKIVYEELSSFLGEPGEIKLEGKKPKVALMVGLQGSGKTTSAAKLAEYYKKRGYKVGLVCADTYRPGAYEQIQQLGEEVGVPVHGDPEEDNAVELAVGGVSEFREDPQDLILIDSAGRHRKEENLMKEMKEISRKISPDEIILVIDGTLGQQAEAQAAAFNEATDIGSILITKLDGTAKGGGALSAVAATGAPIKFIGTGEKIGELELFKPERFVARLLGMGDIETLLEKIRETTEPEEIESERMKAIMAGKLSLRDVYEQLEKLSDMGPLKKMLQMLPGVGMSLPEDQIQVGKDKLNRFKVIMKSMTDEELDDPKILNRSRIKRIAEGSGTTEGDVKELLDQYENMQKLMKSFSKERAPQMKKLRKFFKQMPKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF00</accession>
    <name>A0A133VF00_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04984">
        <property type="protein sequence ID" value="KXB04984"/>
        <property type="gene ID" value="AKJ48_00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="264"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="338" mass="37554" checksum="D9FF0D2745208267" modified="2016-07-06" version="1">MKGLILAGGYGTRLGPIGQRMPKAMIMVDGATALNHLLNRLDKVGMESLIVANRRFEDFFEPYDNLIIEETTSDEEKPGAVSAINQIIERENINEDLFVLASDNYFSEGFEDFLDHYDGDPLIGVFHIGAKPDLDPAEMGTLGFEGCDQYPPPKKGFTITEFKEKSPEPISEYIGTGAYILPKSIFPNLEEFCAGQQRDDMGSLIEYFLENDITVKGYHFSGEWHDVSHTSYLEALSDGNLVKSDERYIVVDKEVGGLVFSITILHAGKQTTGHSHEEAGEVYFFAEGEGVLELNGDKRAVRAGDALPIPPGKFHRVYNTSDKDLVFLSAFEKYGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF23</accession>
    <name>A0A133VF23_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05043">
        <property type="protein sequence ID" value="KXB05043"/>
        <property type="gene ID" value="AKJ48_00570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="162" mass="18372" checksum="29CBFE64AAFF0BA0" modified="2016-07-06" version="1">MTNHFRKTGVLTQEDLENNFPPPERREKGPVAVIEDVEEIPCNPCKEVCPFDAIEMNSLTDPPKLNFEKCTGCALCLRYCPGLAIFIVDQANSPDEKTWITIPYEYLPIPDEGDEVKGLDREGNEFPAKVVRVVRARKGVDFYLVTIEVDEELQDIVRGVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF27</accession>
    <name>A0A133VF27_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_00530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05046">
        <property type="protein sequence ID" value="KXB05046"/>
        <property type="gene ID" value="AKJ48_00530"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.251"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="143"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB05046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="509" mass="55198" checksum="325BFA471D6B5ACA" modified="2016-07-06" version="1">MQTHFPIQIVSILIPLIGSFLFPLLGRRLKIKKLSFVSFLLLLVPLISFSGIILKFGLGEGVADPVFFSQRYIGSFSMLLDSLSMPFVLGIAIVTALVALYSAPYMKHRIREMKAEGLEVQSPGTFFMLYTMFSASMIGIVLSTNLIEFYIFLELSLIPSFLLISFFGYGDRIRIAFMYLLWTHIGALVFLLGILYLGLTTGTFNILNIQNLTINLGLGQGLPILVLIAIVIGLLVKMATFGVHIWLPYAHAEAPTPVSALLSPNLIGISGYALVRIAYGLFPAQFAEISLYLLALAFLTAIYGGLMALAQDDFKRLLAYSSISQMGWILLGISTLTPDGITGAMLLFLSHAFGKSILFMSAGVLIVRFDGLRSISKMGGLVSKVPIFGGLVLLGFMFIVGLPPTLGIWSKILIVIGAFNMLSAMGTAAFALLALGLIVAAGLTATYSFVTLKEIFLGELPRGLKKATVGCWSTMTIVMGIVALVGIAFFFYPSFIIDPLKDLISNILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF40</accession>
    <name>A0A133VF40_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05059">
        <property type="protein sequence ID" value="KXB05059"/>
        <property type="gene ID" value="AKJ48_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="114" mass="13413" checksum="B7D52D144741F23A" modified="2016-07-06" version="1">MSGREFESLAAEISTLLNLSTTEEEILSLLLRTKKKLRIEEITDQVKRSERGVRERLKSLHKKGLIDREWMITDSGQKAHQYFVIHARDLIKKVKKETSRRVQKIEKRARKIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF44</accession>
    <name>A0A133VF44_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05061">
        <property type="protein sequence ID" value="KXB05061"/>
        <property type="gene ID" value="AKJ48_00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="160" mass="18208" checksum="B9AD41CECD49C505" modified="2016-07-06" version="1">MKNKHIFLVCIIVASFVWTASLVAMNYNQLPDQIPTHYGVSGDPDSWGSKTTLLIYPSLQVAFLAISLVIYKYPNYANIPLTIGLKHLSKNLRERAYEIVRDVVFITMAIVTFLMLYLTRETLEVAKGQAMSINLWGVLAFLIFLAPVIVYYSIKMRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF46</accession>
    <name>A0A133VF46_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05063">
        <property type="protein sequence ID" value="KXB05063"/>
        <property type="gene ID" value="AKJ48_00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="175" mass="19771" checksum="0AAE4756D7713885" modified="2016-07-06" version="1">MEVREIAQALLSHKDKKGSTAKWFVFSFIPLLNLWVMWKAAEEIAGHEKIVKEYESIDHKKPRGSTGAWFALFFVPAILGVLASFSIFFGGLGFGLVMAIALGIVALVIGLYVLWRMAEVVSGHDKTYEKYELLVHKERKDSTVKWFIIGIIPIVNLYLLWKVGEAISGHETVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF55</accession>
    <name>A0A133VF55_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05076">
        <property type="protein sequence ID" value="KXB05076"/>
        <property type="gene ID" value="AKJ48_00425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="86"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="313" mass="36867" checksum="84D4B97FD208C165" modified="2016-07-06" version="1">MTHQQKIAEMGLRDLPLRFRIQLYREALQLHDENDWGCVRIVEELSAKHQVKIWNSTVSRWLTGKRNPEAKCTLFTPKPSPELSYFTGVFTGDGTITSGSWPTTKVITLATVDKDFAEMFNRAAVTILGHSKPYRMHYYAQKYWVKIHSTLLADFLQEPFSKIKRYVEEHPAEFVRGFFDAEGSIGVTLTKDRLEPMLNVVNTNPDYIHSIEDLLKKQFNIKLRTSRRELGENRRAFYTLYTYRYKLINRFDSKIGFGILRKREKLNDVLKLLEKHSARRAAVKWKELYAKAGRKWKKKNRRAKSQRFKNKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF60</accession>
    <name>A0A133VF60_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">AKJ48_00580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05044">
        <property type="protein sequence ID" value="KXB05044"/>
        <property type="gene ID" value="AKJ48_00580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB05044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="251" mass="27412" checksum="6DED898EDFC6CAAF" modified="2016-07-06" version="1">MEKEIIRDFESEKISQNELKKALDSVAVEESFDLLVNGTRVASLMITPSDLTELGYGYLLAEGIVESVDQIITVRVKGREIHTFIEGDEKLEELLELRSSGCVGVHWDREEQVFVETDFALTSDLIFRSLRHLETSVYDKTSGSHSASLIGEDGRVLAKTVDVGRHNAYDKIIGKAVTNGIDLSKTMLLSSGRQSAGMVMKAARVGIPIIVTKAAPLSSGIEAARKAGITLACFANNEKIKIFAGSERIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF62</accession>
    <name>A0A133VF62_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_00420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05075">
        <property type="protein sequence ID" value="KXB05075"/>
        <property type="gene ID" value="AKJ48_00420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026453">
        <property type="entry name" value="PGF_pre_PGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04213">
        <property type="entry name" value="PGF_pre_PGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="113"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="406"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB05075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="897" mass="100161" checksum="A19C6EFF5F4B9D7F" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF66</accession>
    <name>A0A133VF66_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0282 protein AKJ48_00405</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0282 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000002">
        <property type="protein sequence ID" value="KXB05082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05082">
        <property type="protein sequence ID" value="KXB05082"/>
        <property type="gene ID" value="AKJ48_00405"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.77"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01406">
        <property type="entry name" value="UPF0282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014426">
        <property type="entry name" value="UPF0282_hydrls"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF4">
        <property type="entry name" value="PTHR43546:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004944">
        <property type="entry name" value="UCP004944_hydrls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="315" mass="36635" checksum="23F61E98ED6861F6" modified="2016-07-06" version="1">MRVRPLAFESLGVRGMATYVETDDVKMIIDPGSALGPRFRLRPHEREYLALHQTRQDILKTAKDVDLLTISHYHFDHFIPNFENWKFIWSSPKMARELYTDKLILAKDISENINTSQRKRGYMFQKKNKDHAKKIRATDGQKFEFNSTKLRFSRPLYHGPHETKLGYVLTLTVETPECCFLHAPDVQGPMYEESLKHILDQAPDLLMLGGPPIYIRFKLDEKDLTNARQNLVKLAEKIPTVVVDHHLLRTLDYEKYLEPASSAAEDAGHELLTASELIGKEPELLEAKRKELHEKEPVKEEWYERVEKGELEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF75</accession>
    <name>A0A133VF75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05093">
        <property type="protein sequence ID" value="KXB05093"/>
        <property type="gene ID" value="AKJ48_00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="92" mass="10191" checksum="7171AE2086765E32" modified="2016-07-06" version="1">MVKVKFFASFREAVGEKGVEVKSAENIEILLEKLVEQFGEKLEHQFYEQKSGELRDSVNILVNGRGINLLEGLETPLKDNDTVAIFPPVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF80</accession>
    <name>A0A133VF80_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_00065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05099">
        <property type="protein sequence ID" value="KXB05099"/>
        <property type="gene ID" value="AKJ48_00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB05099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="339" mass="36363" checksum="425F9F29D09B7AF3" modified="2016-07-06" version="1">MKELLTKLANTYGASGREESIASLVKSELEDSADSVKMDKFGNVIATKEGSSNFSIMLAAHTDEIGLAVEKVSEDGFAFPARVGGWDPRILPTNPMKSDDGWGLVSTSPIELLDEEDKKKAVRHKDLFIEAQDLSPGGFLVQDAKVTELGNPNVVVGKSLDDRAGLSVMIEAFKKIEDFEPNIHAVGTVQEEVGLRGAGVAAYKLNPDLGIVLEVALADDVPVGGPHTPVVRLGKGPAITVKDASMISHPKLTNFLIQVAESEEIPYQLELLEHGGTDAGRIHLTREGVPSSVIGIPTRYLHSPVEVLDVKDLERGVDLLASTLESLKHSDLESFSTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF92</accession>
    <name>A0A133VF92_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05100">
        <property type="protein sequence ID" value="KXB05100"/>
        <property type="gene ID" value="AKJ48_00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="76" mass="8086" checksum="6859D51799229813" modified="2016-07-06" version="1">MVEAYILITSAIGKVRGVSEKIEGLENVKSVRIVTGPFDLVALVESEDLSTLTNTVVVGIREIDGVVDTNTAIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFB8</accession>
    <name>A0A133VFB8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Riboflavin kinase</fullName>
            <shortName evidence="17">RFK</shortName>
            <ecNumber evidence="5 17">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ribK</name>
        <name evidence="20" type="ORF">AKJ48_00185</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 17">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5 17"/>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05117">
        <property type="protein sequence ID" value="KXB05117"/>
        <property type="gene ID" value="AKJ48_00185"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01285">
        <property type="entry name" value="Riboflavin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023470">
        <property type="entry name" value="Riboflavin_kinase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 17" id="KW-0288">FMN</keyword>
    <keyword evidence="12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="18">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="CTP-dep_RFKase" evidence="19">
        <location>
            <begin position="96"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KXB05117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="217" mass="24397" checksum="B64E507BA31ECB3E" modified="2016-07-06" version="1">MRRLSILLELARLGAHSEPCQITSKELGEKIGCSQQTAARWLKKLSEEGLIDQDVGSRGQTVSLTSEGIDVLRSLRKDLNEVLGEVPQSLKLTGRIVSGLGEGSYYVDKEEYKKQFQEKLGFNPYPGTLDIKLDRKSLRIKERLHSTQSKRIEGFSTQKRRFGGGKCFSARVGDMEAGIILPDRTHHKKIIEVIAPEKLRDKFSLEDGDEITVEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFD8</accession>
    <name>A0A133VFD8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05124">
        <property type="protein sequence ID" value="KXB05124"/>
        <property type="gene ID" value="AKJ48_00230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="144" mass="16273" checksum="95389E3EA0357EA3" modified="2016-07-06" version="1">MNSIVEIDDERVEKFITCTLACHSKVKTLLIIGSAARGELTKYSDIDGVMLTEVSEKDVISELEEDFNELAAKRFGKSGGNEFYSPHWSLFIYSEKAFTDKSIFSEYCPLPLEFTLYNLKHNSKLVFGQDASQTQQQAGLWSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9D9</accession>
    <name>A0A133V9D9_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="11" type="ORF">AKJ48_04290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="LHYB01000091">
        <property type="protein sequence ID" value="KXB03039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03039">
        <property type="protein sequence ID" value="KXB03039"/>
        <property type="gene ID" value="AKJ48_04290"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.925"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB03039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="426" mass="47652" checksum="5BC1D1AC7E32FC5A" modified="2016-07-06" version="1">MGDRVQRPRGTRDLFNGELERVRHVERVFKSIFKRYGYQEVETPIFESLELFTKKSGSEVVNQIYEFKDKSGRELALRPELTAPVVRLYNNQLKSEPKPLKLCYFGSCFRYERKQANRWRQFSQAGVELIGSSRPESDAEMVALTNDVASQLELKDYGLRVGDIGVLRKLLIEGGIPIDNQDSILRAIDSKDESRIEGELDKSGVNEEIQEKIRELIKLKGDPNVLEEAKELLEGVKDSEKTIRDLQEILSRAQQLGVRDINIDMGIARGLEYYTGFVIELYSDDVQLGGGGRYDDLIEVLGGEPTPAVGMGFGIDRLAQLLGDQGRDIGVESLESVVLPTGDEMLDECLSIATELREKGLSIDVDLMGRKLDKALSYADSRGAKYAIIVGPEDIGEGKVTLRDMGTGNQEKVSRGKIVKELSKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9R4</accession>
    <name>A0A133V9R4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_04125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000081">
        <property type="protein sequence ID" value="KXB03200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03200">
        <property type="protein sequence ID" value="KXB03200"/>
        <property type="gene ID" value="AKJ48_04125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019300">
        <property type="entry name" value="CooT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10133">
        <property type="entry name" value="CooT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="61" mass="7136" checksum="EDBF457C3923C47F" modified="2016-07-06" version="1">MCELDVFIDGEKVFERAIRLRRDKDKIIVRSVLGNKKTLSDVEFDELDIPSEKLTLTKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133V9Z0</accession>
    <name>A0A133V9Z0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-cone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_04060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000078">
        <property type="protein sequence ID" value="KXB03251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03251">
        <property type="protein sequence ID" value="KXB03251"/>
        <property type="gene ID" value="AKJ48_04060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB03251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="83" mass="9388" checksum="3E1D7388E24322A6" modified="2016-07-06" version="1">MATNVVKKSGEKEPFEHKKIVDSILTTGAPPDVAAQIADEVEEAVEEEVSTEQIRNMVLQKLGNIKQEWVDSWKEYEKTKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VA66</accession>
    <name>A0A133VA66_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_03955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000073">
        <property type="protein sequence ID" value="KXB03358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03358">
        <property type="protein sequence ID" value="KXB03358"/>
        <property type="gene ID" value="AKJ48_03955"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.807"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB03358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="219" mass="24853" checksum="1D21147D286AFBA7" modified="2016-07-06" version="1" fragment="single">ELVPSYTIFFSGCPFKCQFCQNWDISQNPQNGVEVSPQTLASSASTGRREGARNVNWVGGDPIPNLHNILAALNNCKVNIPSVWNSDMYLTIEGMKLLFGTQDIYLTDLKYGNNDCALKYSKIPNYWEIVPRNHRLAAADAELIIRHLVLPGHVECCTRPILEWIVDNLGSMTRVNLMNQYRVCYRANEYEEINRPITAEEFKKAKEIAQEVGLENVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAE0</accession>
    <name>A0A133VAE0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000071">
        <property type="protein sequence ID" value="KXB03406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03406">
        <property type="protein sequence ID" value="KXB03406"/>
        <property type="gene ID" value="AKJ48_03920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="308" mass="35417" checksum="EBAF97D3D02DDB3E" modified="2016-07-06" version="1">MLSSKSLDLIDTLGEEPRYARDLTSVMSSRTLFEKLEELENAGFIEKYVEKEGRGRPRHYYRLTPAGRILRRKLIETRDDLLFLSCINSLKRQEIPVTAGVSTSLTDFYGAPLVLTQLDIIVPKASRGEARKIVDVQKKRASKRGWLPSSIEWGVDIAPIPWRNFEKRAVKVNGVPYLSVEDLIILTLHRNEARLISCLPRVVHEKSQTINHDYLLELAKDFNLVGRTGALLDMTNRLAGEEITQPSTLKNFERLTPKRKIESPRSRQPLVKKGIVPLKEDPVDVGIRERWHVVFPTFREVREIWELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAN9</accession>
    <name>A0A133VAN9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000066">
        <property type="protein sequence ID" value="KXB03522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03522">
        <property type="protein sequence ID" value="KXB03522"/>
        <property type="gene ID" value="AKJ48_03805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="328" mass="36816" checksum="DC64ECE7C0F26089" modified="2016-07-06" version="1">MPKYDDVGSLPLPEKVNRGEFERGLLNFEDWALKICRESMELKIGRGVEVPCYPQLRDMINQFLEPLKDPKLTEEPYLIRKGEANLPELLALRESSTKLPQLKMCVTGPLELTSAEFESKIHGDILLNLARSLKRFIKNAESMRRVDVGVVSIDEPSLGMNPQLVFDDETLIQAWDIVGDTKMDVQVHLHSALFNETACKSSGVDIIDIGTAGRPENLGLIDPELIDSYEKGVRIGVSRTDALSMAAEFNERNNVNVWESGVDWQILLDQIDPPARIAERIEKAYERFGELVKYFGPDCGVGGVIPRDFAAKILENTKSGINLFRKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAP7</accession>
    <name>A0A133VAP7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000067">
        <property type="protein sequence ID" value="KXB03494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03494">
        <property type="protein sequence ID" value="KXB03494"/>
        <property type="gene ID" value="AKJ48_03825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="101" mass="11544" checksum="DB88EE675C8CDF2F" modified="2016-07-06" version="1">METITARIPKDLLQDLKEIESEEKTERAEVIRKLLDGAVKEWKVKKALEKLRDGKVTFRTAAKLAGLTYVQMLDQAEQANIPLEYSMKDLEADLVKLKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAS9</accession>
    <name>A0A133VAS9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000066">
        <property type="protein sequence ID" value="KXB03524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03524">
        <property type="protein sequence ID" value="KXB03524"/>
        <property type="gene ID" value="AKJ48_03815"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.751"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="295" mass="32545" checksum="11C7D36C28BB65BB" modified="2016-07-06" version="1">MILLQLKPGNVHRYSNLKEETFGQFITGAIVIGPSLRKAVEKGFNAGEEKLEVSNIQVGDMIKEGVSATRTWARENTNLGTLLLLTPLAAAGGMTIAKETRHTAGKLRENLSNVLRSTDSVDALNVYDAILISGARGLGDVARLSVKDEASKEEIAREDITLYEIMEISSDWDMIAKEWVTDMQVTFEEGFPLLKKFYGEKKDLNAAIVQTFLKILSTHPDSFIRRRHGERIAKKTSERAKTVIEEGGAFTPDGRSVINKLDKQLKEKNINPGTTADLIASSLMVALFDGLKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAW2</accession>
    <name>A0A133VAW2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AsnC_trans_reg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000064">
        <property type="protein sequence ID" value="KXB03583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03583">
        <property type="protein sequence ID" value="KXB03583"/>
        <property type="gene ID" value="AKJ48_03745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="94" mass="10684" checksum="1AA1D4609C971949" modified="2016-07-06" version="1">MIRYEDKPKLKRNRRLIMQAIVYVRTDPGMALDILDEIAGIEGVKFTAAVTGRFDIITRVEVENLEELGEKVVEEIHNLDGVRYTETAPIVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAX1</accession>
    <name>A0A133VAX1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor IF-2B subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000065">
        <property type="protein sequence ID" value="KXB03555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03555">
        <property type="protein sequence ID" value="KXB03555"/>
        <property type="gene ID" value="AKJ48_03780"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.744"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043917">
        <property type="term" value="F:ribose 1,5-bisphosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005250">
        <property type="entry name" value="Ribulose_e2b2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00511">
        <property type="entry name" value="ribulose_e2b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="298" mass="32931" checksum="A9DB8CE269D47DA6" modified="2016-07-06" version="1">MEIRGAGKIARTGARGLKLTAEKSSAGNTEEFLKELKEVSDILLGTRPTAISLANSLRFVTKDIESLSETEDLPDLKKRVISRAEEFVELSEKARERIGEIGSRRISDGDTIMTHCHSTNALSVIKTAFNQGKDIRVIACEARPRQQGFITARELMESNIPTTLIVDSAARYFMKDVDKVIVGADSIAANGAVVNKIGTSQIALTAYEARVVFFVAAESYKFHPQTLVGRLVEIEERDPKEVADPSKLPNVEIRNPAFDVTPAEYIDLIITERGIIPPEAAYEILREHFELGPESEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VAZ7</accession>
    <name>A0A133VAZ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000064">
        <property type="protein sequence ID" value="KXB03585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03585">
        <property type="protein sequence ID" value="KXB03585"/>
        <property type="gene ID" value="AKJ48_03765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004454">
        <property type="entry name" value="HD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00295">
        <property type="entry name" value="TIGR00295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB03585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="172" mass="18942" checksum="45807870C8858BEB" modified="2016-07-06" version="1">MLTRERALQILSEVGCSPKIIEHTKAVAQESVRIARQISQSGHKVNTSLVEIGAILHDIGRSHTYGIKHGIEGAQILREKGLEDLTGFAENHLGAGISAEEAERIGLPKKDYLPATLEEKIVTYADNLIRGDEIITFEEAVEELKGELGPDHPSLERFSELREKLRDLGGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBJ6</accession>
    <name>A0A133VBJ6_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000058">
        <property type="protein sequence ID" value="KXB03828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03828">
        <property type="protein sequence ID" value="KXB03828"/>
        <property type="gene ID" value="AKJ48_03630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB03828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="334" mass="37315" checksum="F80F7ABC06E13F02" modified="2016-07-06" version="1">MTEWHGLYSVTWNVTSGCNFSCKHCYVPEVERQDLGTEEAKDLLDGLADFGVEELYMSGGEPLLREDLFELISYAVDSGLHTDVITNGWYMTEEKATKFGKSGASHVSVSIDGLEDTHDDFRNKKGSFQKCVNAIKLLRSAGVKIYLSPTFSKHNLQQLPDLLDLASTLGTDFSSKVMIPMGQASKLKRYCLSPKEQKEFYKSLHTIMNSLDNGMEITTTCNPYSIFLEDDKPEPDEERIRGGCTGGITLLCVGADGTVTPCSRLQVPLGNVREDSLEDIWYDSEVLDTLRDRDNLKGKCGDCEYRNWCGGCRAMAWAHLGDYLAEDPTCWLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBZ8</accession>
    <name>A0A133VBZ8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_03505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000054">
        <property type="protein sequence ID" value="KXB03976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03976">
        <property type="protein sequence ID" value="KXB03976"/>
        <property type="gene ID" value="AKJ48_03505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB03976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="170" mass="18883" checksum="E3B777ECD40324D7" modified="2016-07-06" version="1">MAKLIVTSRGLEAAPQTLRVIKDAFPDAEVGRTGFRGVITMDAEGYALKLAEHVYQECFVDIGRAVAIFSEVESTREEVEEAAVRIGEENIERGESFCFRLYKRGSHQFEKDTPELEEKIGGAIWEVLEGKHGEEPEVDLETPSVTIDAEVLGSKTAVGVLRREWEVDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VBZ9</accession>
    <name>A0A133VBZ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000055">
        <property type="protein sequence ID" value="KXB03950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB03950">
        <property type="protein sequence ID" value="KXB03950"/>
        <property type="gene ID" value="AKJ48_03535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB03950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="151" mass="17361" checksum="2D44F495B0BFE5E3" modified="2016-07-06" version="1">MGWDECGPTPETLEKLDLDKLVGIKSDLKSKNHLQFLSFPRNSLLVVSIIEGVKTVKLDRSQLIIKRVNPPLEGDSELFDLFPLTWTAWDEEKKRRMRGELIGLSKDCFFIGEIDRKVVGNVWYTHSKGCPKEFLQKSSRTLRYLPKHSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC37</accession>
    <name>A0A133VC37_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mevalonate kinase</fullName>
            <ecNumber evidence="2">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ48_03470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="2"/>
    <dbReference type="EMBL" id="LHYB01000053">
        <property type="protein sequence ID" value="KXB04009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04009">
        <property type="protein sequence ID" value="KXB04009"/>
        <property type="gene ID" value="AKJ48_03470"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.656"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB04009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="121" mass="12635" checksum="C5A1E4367DE0C7D1" modified="2016-07-06" version="1" fragment="single">MIASAPGQIFLFGEHAVVYSQPALAAAIDLRTRVKSESRDDMRVLVDSEGVGKLEGVVRGKGGQWTIEKKSGDVRELEHVVKAVESTFSHLGDGGGLELEILSDIPVGSGLGSSSAVTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VC89</accession>
    <name>A0A133VC89_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000051">
        <property type="protein sequence ID" value="KXB04059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04059">
        <property type="protein sequence ID" value="KXB04059"/>
        <property type="gene ID" value="AKJ48_03420"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.646"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="6">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="5">
        <location>
            <begin position="538"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="656" mass="74399" checksum="EB26768FB7F39428" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCD4</accession>
    <name>A0A133VCD4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="4">IGPS</shortName>
            <ecNumber evidence="4">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpC</name>
        <name evidence="6" type="ORF">AKJ48_03350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000049">
        <property type="protein sequence ID" value="KXB04118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04118">
        <property type="protein sequence ID" value="KXB04118"/>
        <property type="gene ID" value="AKJ48_03350"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.606"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="5">
        <location>
            <begin position="17"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="273" mass="30067" checksum="EF77EB1BB6992FE5" modified="2016-07-06" version="1">MRLIETHIVGGLFLTILDEIIESTRKRVGEESRLHPIEEMKLDSSERRSLRESINQGPEAAVIAEIKRMSPSSGDIRPDVDLVKVTGEMTRGGSVGISVLTEPDYFNGRLDFIPVVREATHLPVLRKDFIVDKYQLYESAEAGADAVLLITEVLGKSLPEFVKTSRELEIECLVEVSNEDQVELAIQCAPDLIGINNRDLKSMKIDPSRTERLAKLIPDEVTVVSESGINEAADVKRMLEDGADAVLVGTSIMKSKDIEGKVRRLTGVGESNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCE5</accession>
    <name>A0A133VCE5_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">AKJ48_03355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000049">
        <property type="protein sequence ID" value="KXB04119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04119">
        <property type="protein sequence ID" value="KXB04119"/>
        <property type="gene ID" value="AKJ48_03355"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.607"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="217" mass="23457" checksum="5232D0A7C61E5B01" modified="2016-07-06" version="1">MVRVKICGLTRVEDVKTAYEAGADMIGVIVNAKVPTPRNLDYDEARKILEQTPSGIEKVVVGMPGDLSEGLEIIEELDPDYLQMHSYPSLSEVGELKDITGKKLIITVSIPRKSLDSAKLIVRAEEVAEVSDFILLDTEGPGGGETGKTHDWTASRKIRDALETPVFLAGGLNPSNVREAIEKVQPYGVDVASGIEAEPGIKDPEKVKAFVKASKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCJ4</accession>
    <name>A0A133VCJ4_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_03340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000048">
        <property type="protein sequence ID" value="KXB04147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04147">
        <property type="protein sequence ID" value="KXB04147"/>
        <property type="gene ID" value="AKJ48_03340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="115" mass="13238" checksum="CB69DD64D1736D95" modified="2016-07-06" version="1" fragment="single">VFETAKSELAKLRDDNQEYQEILENLIVSGGHTVEEQKKEGGSPDECIIYSLYVYHLMPDDEELLELRKACESGKLICGDCKKKAIKFLNKFLKNHKKNRKSVKKKIGKIIEDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCV4</accession>
    <name>A0A133VCV4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase_M50 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_03200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000044">
        <property type="protein sequence ID" value="KXB04279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04279">
        <property type="protein sequence ID" value="KXB04279"/>
        <property type="gene ID" value="AKJ48_03200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.571"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PTHR13325"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="6">
        <location>
            <begin position="121"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="399" mass="43523" checksum="A2FDB591B1BD9E0C" modified="2016-07-06" version="1">MQMHILLLILILITGVWAIILLVDRYFDLESHGLDVGPGILLWRTKYGLNALDRISGAWSGGWRFFGIFGMGVGVIFMIAVFVFLILNTILLFTIGAPPGMGGAGVKLAVPGMTIPLLLGVIGFASVLLVHEPAHGIMARRVGLPVKSTGLLLFAVIPGAFVEPDEERLKKASISDRLQVYGAGSFANILFGLLCFGIILALITPLSGLYISGVGENTPAENVGLQPRMHIMGIGYEEDNLITIDNYQVFADFMDNTRPEENILLYTEKTRYNITLENKDNQGYIGIWLTASTSRSSLIHPLSIYGVAVFEILGRPIINQYAYDAAVPWLLIEVLKWMFTLNILVGLFNLLPLKPLDGGHIAEGLTEKVVSKRTANVIANALSVATLAILLMNFAPIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCW1</accession>
    <name>A0A133VCW1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_03140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000043">
        <property type="protein sequence ID" value="KXB04289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04289">
        <property type="protein sequence ID" value="KXB04289"/>
        <property type="gene ID" value="AKJ48_03140"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.563"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="274"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="373" mass="39875" checksum="9DF29821C01A7B5F" modified="2016-07-06" version="1">MRLFSFALKNLGRRKIRTGLTILGIAIAIAFSFILLSVDAGSEELMAGAGRLGPDIEAKVKGTQLALTTDENYAIVLEKVEGVRKATPAIMWEYWSSEKPGFTIILGMIPSDAREIYADIEVVEGRPLDNSDNFAVELGSHAASQIGLSVGDNLEFEGDNFEVVGVLEETGSIVDIMGVMPLWSLQSALQTPENKASGIWIWVEDGANVGSVMTTIENDYPELSATEGLTMLEYTEEFTKFGGAIRLIVLTVAILIGTLAAMNTVAMTTFERTREFGTMRALGASGGYVFKLVLIESILLCVIGGLIGSLLGFVGSLGAESIIMDMVGLDIVAVPLTVPATAIGIAIIVGLVAGIYPARRVSKQEIVEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCY3</accession>
    <name>A0A133VCY3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_03145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000043">
        <property type="protein sequence ID" value="KXB04290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04290">
        <property type="protein sequence ID" value="KXB04290"/>
        <property type="gene ID" value="AKJ48_03145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="227" mass="24804" checksum="425C026E3DE993AC" modified="2016-07-06" version="1">MTLIELQDVDKVYETDATSVKALDDVTLIVEKGEFMSVAGPSGSGKTTLLNLIGGLDKPTSGKVKISNRITGRMTDSELDSMRLEKIGFVFQTFNLIPTLTALENVELVLSITGLSSSEQEERAKKLLEMVGLGDRLNHRPSQLSAGERQRVSIARALANDPEIVLADEPTGNLDTDTGNEVVDLMRKLNKELNKTFIIVTHDPNVAKRTDRIVRLKDGAIVGEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VCZ7</accession>
    <name>A0A133VCZ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ORF">AKJ48_02965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04329">
        <property type="protein sequence ID" value="KXB04329"/>
        <property type="gene ID" value="AKJ48_02965"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.504"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="285" mass="30823" checksum="B04B4E3C00ED9DBE" modified="2016-07-06" version="1">MEERASILLEALPYIQRFYGKTLVIKLGGTLLEDEELKDSIYQDIVLLNYVGMKPTIVHGGGTEISKEMEKAGKKPEFIEGLRVTDEETMEILHKSLGGKINKEIVLGLNKHGGHAIGVSGMDGGLVQAKKIESKSGEDLGFVGEVEEINPSITQYLLDEDYIPVIAPIGADKEGNSLNLNADIVAAELAPSLEAEKLILLTDVPGVLEDPNDEDSLISSLTLEEAQKLVEDEKITEGMIPKVQACVKCVESGVERAHIINGETPHSLLLELLTEGGIGTMIERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD02</accession>
    <name>A0A133VD02_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="6">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">Ornithine acetyltransferase</fullName>
                <shortName evidence="6">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="6">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="6">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">N-acetylglutamate synthase</fullName>
                <shortName evidence="6">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="6">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="6">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">argJ</name>
        <name evidence="7" type="ORF">AKJ48_02960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="6"/>
    <dbReference type="EC" id="2.3.1.1" evidence="6"/>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04328">
        <property type="protein sequence ID" value="KXB04328"/>
        <property type="gene ID" value="AKJ48_02960"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.503"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023238421" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="6">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023238422" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="6">
        <location>
            <begin position="192"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="6">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="409" mass="43161" checksum="DCBED88616CD86B0" modified="2016-07-06" version="1">MISVVKGGLTAVPGFRATGVRTGIKHRGLDFFLLASEKGSVPSAGLFTSNKVKGAPIQVTQKNLEDQKLGAIVANSGCANAYTGKTGLKNAEKMTKLTARALDMDPDDVGVASTGLIGTQLPMDLIQEGVDKALETLSNTWEAGENAAKALMTTDTMVKEIAVETDLEDGTKVTIGGAAKGAGMIHPDLQATMLAFITTDAYITPAGLKSALKKSVDQSFNMVSIDRDTSPNDMVIALANGLANNERITRKHPSKKFQEGLDKVTTELAKKIAKDGEGAKHFIRVRVEGAKNLENARLAARAVAGSNLVKAAVFGNDPNWGRIVTALGYSGASFKPEKVSISVRSEGKEAPVVLDGEGLPGESLNQASKIMDSDEIEIYIKLDSGKGAATAWGCDLTKEYVEINSKYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD06</accession>
    <name>A0A133VD06_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alanine dehydrogenase</fullName>
            <ecNumber evidence="1">1.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000043">
        <property type="protein sequence ID" value="KXB04284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04284">
        <property type="protein sequence ID" value="KXB04284"/>
        <property type="gene ID" value="AKJ48_03110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="85" mass="8777" checksum="5F1FB082A17D1E63" modified="2016-07-06" version="1" fragment="single">MPAYLEDLGAAGVKIVNAHPKNPERHDMPSVMATILLLDSRTGAPLAIMDGTLITNMRTGAAAAVAAKHLARKDSKTVAMIGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD09</accession>
    <name>A0A133VD09_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_03040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000041">
        <property type="protein sequence ID" value="KXB04305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04305">
        <property type="protein sequence ID" value="KXB04305"/>
        <property type="gene ID" value="AKJ48_03040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="97" mass="11276" checksum="A6625E9A7588183C" modified="2016-07-06" version="1">MKIFIVVYKQPDRSKSVQLSRALHGYTDSSNYGKYSYEREGLLEKITYLKLMNGVFILKERDSDRLIKLLEKYQAEYYAGPVTKTSGKGEVLLKDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD17</accession>
    <name>A0A133VD17_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000037">
        <property type="protein sequence ID" value="KXB04348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04348">
        <property type="protein sequence ID" value="KXB04348"/>
        <property type="gene ID" value="AKJ48_02875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="244" mass="27423" checksum="5F862EC0881425C6" modified="2016-07-06" version="1" fragment="single">IFCGSHSGCCSRDLVLYTGKLMLLTLLSALHGLEGGKDKGKWPLVASKFAEAGYASLRFNFRGCGRGGEKSEGKFEDTTLSARIRDYKSSLNFLQSLKWIDVDRIGVIGSSLGGMVAISGRDERVKTIVTMSSPYKVPRYGEPRIPEKRGDYYILPSGRRFKEDFYEDIRGYDLLEDVKEAPPLLIIHGTSDEIVPPEHAQTLYDHAGKPKRVEMIKGADHAFSESRHLEKALQISIDWFERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD18</accession>
    <name>A0A133VD18_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">AKJ48_02975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="LHYB01000039">
        <property type="protein sequence ID" value="KXB04330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04330">
        <property type="protein sequence ID" value="KXB04330"/>
        <property type="gene ID" value="AKJ48_02975"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.506"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="151"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="307" mass="34002" checksum="7C59AE148DA89CC7" modified="2016-07-06" version="1">MAKIKHLISVQDLTDEELKEILDQAGELKEKQKSGEPHESLRGKTLGMIFAKPSTRTRVSFETAMTQLGGHAIYLGWDTLQLGRGETISDTAQTLSRYVDAVTARLFEHEKIKELAENSGVPVINGLTDLLHPCQAISDLFTIREQKDGFEGLKLAYIGDGNNVCHSLLLSCAKVGMNTSIATPKGYEPNQEIVEKAKQKASEKSSKVKILTDPEKAAFNADVIYTDVISSMGQEEEREQRLKDFQGYQVNSELLSMAKEDVIFMHCLPAHRGEEVTAEVIDGPNSVVFDQAENRLHSQKAILVMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD41</accession>
    <name>A0A133VD41_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04369">
        <property type="protein sequence ID" value="KXB04369"/>
        <property type="gene ID" value="AKJ48_02870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="216" mass="25146" checksum="6C319CCCF5D37D6A" modified="2016-07-06" version="1">MDLNFDIIKNRRFYDGRRGIWYLCWFHPEKVSKAPKRFREFFEGRVVEREVPDFEELKNSVTGYGGVEPAFCKGEWKCTGDFSFAPIRYAHENMDQGRHYRVLKALVADEDSDIACCELPVWGTIEDGEEFVEHTGHIDAVEVKNGEVHVLDYKPGSDEPHDHARQIEAYRRLLALRLRKEGSEHPRPESIGVGIFNDEQIWRCDFQPADLNDDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD65</accession>
    <name>A0A133VD65_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4Fe-4S domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_02730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000034">
        <property type="protein sequence ID" value="KXB04396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04396">
        <property type="protein sequence ID" value="KXB04396"/>
        <property type="gene ID" value="AKJ48_02730"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.447"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019224">
        <property type="entry name" value="DUF2148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09918">
        <property type="entry name" value="DUF2148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="5">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="164" mass="17907" checksum="93A4E5E0C5327D0D" modified="2016-07-06" version="1">MEISAITAPKAAGMDSLVSRVVTDPEMREIAEDMRRIGKERDDLGFVRDGNNLMESDALLLIGTKEHSGLGLDCAACGFESCKEFNEAEEIDFEFGGPNCIFKLLDLGIALGSAAKTAAIHNVDSRIMYRIGVSARRLNFLDATIVIGIPLSAEFKSPYFNRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD75</accession>
    <name>A0A133VD75_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000036">
        <property type="protein sequence ID" value="KXB04367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04367">
        <property type="protein sequence ID" value="KXB04367"/>
        <property type="gene ID" value="AKJ48_02860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="87" mass="9862" checksum="02FF585643130A05" modified="2016-07-06" version="1">MVREVGRVLGGEKTPQNGQQSPRKGEERLRQVLLQFQSGFEEEGREALLRDREIKPDVRSIYKFCELLDYYGCQLKGGSGKSVRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD85</accession>
    <name>A0A133VD85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_02770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000035">
        <property type="protein sequence ID" value="KXB04377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04377">
        <property type="protein sequence ID" value="KXB04377"/>
        <property type="gene ID" value="AKJ48_02770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="150" mass="17409" checksum="4E6FE87FB52B352F" modified="2016-07-06" version="1">MKLPFKSVEVRSFVHATEDLKKVKEIFRSLLPEEIEIEESRAKGHHGDKITILSARINRNPDIREFWHQAMKMMPNKEKEKLSEIAVDRIADDCRLYLRFDKQAAVGEELILTDSGDALHIRINVSAYPAKREIAVEEMRKFISSGLEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VD96</accession>
    <name>A0A133VD96_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydroorotase</fullName>
            <shortName evidence="3">DHOase</shortName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pyrC</name>
        <name evidence="5" type="ORF">AKJ48_02645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000032">
        <property type="protein sequence ID" value="KXB04419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04419">
        <property type="protein sequence ID" value="KXB04419"/>
        <property type="gene ID" value="AKJ48_02645"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.427"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_A">
        <property type="entry name" value="PyrC_classI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="54"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="306"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="429" mass="47584" checksum="E78E03603FE8F021" modified="2016-07-06" version="1">MNGVDLRIENAKVLYRGNLIRVDIMIEDGKIAEISKKPSISQADQNIDLKGALLLPGVIDAHVHFRDPGLTHKEDFSTGSMAAAGGGVTTICDMPNTLPLTDSMEAFNEKVRIGERKSHVDFALHAALPQEIDEGVKLAKAGAASFKLYPELREDFSISDFQEVSPTISIHPEDPRILEEFENTQDFAESRPIRAEISEISRVLDLAPNTHLHFCHTTALESIKLITKARKSRKITCEATPHHLLLNTSHLQELGPIAKTNPPLRSEENRLALLSTLREGSIDMIATDHAPHTREEKERGMEESPPGIAGVETSLPLLFTLVRRGKLSLSRMVESMCIKPARVFGLKNERGILKNALIPEADADFVAIDQHVKWKIKGEKLHGKTKSTPFEGWKVVGKPFLTIVRGETVFKEGEVIGKEGYGRFIPRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDA1</accession>
    <name>A0A133VDA1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dihydroorotate oxidase B, electron transfer subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrK</name>
        <name evidence="8" type="ORF">AKJ48_02650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5 6">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer of 2 PyrK and 2 PyrD type B subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PyrK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000032">
        <property type="protein sequence ID" value="KXB04420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04420">
        <property type="protein sequence ID" value="KXB04420"/>
        <property type="gene ID" value="AKJ48_02650"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.428"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01211">
        <property type="entry name" value="DHODB_Fe_S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023455">
        <property type="entry name" value="Dihydroorotate_DHASE_ETsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="271" mass="29272" checksum="0F5B498018990341" modified="2016-07-06" version="1">MEGSSLEKHRTQVQQLVRVKRETPTIKSFYVDCPSIASSSSPGQFVMVWVIGVDEIPMSVSSAKGGVLGFTVEEVGEATSKLYELREGDLVGVRGPYGNKFDLSEENLLMIGGGSGVAPLAFAAEKAVSEGKKVTAVIGASTGNELLFVSRLRELEVETIVTTEDGTAGVKGLATGVLEDLLVERKFDHLFACGPEPMLKIIFDLAEKYEIPLQVSLERMMKCSVGLCGSCCIGPYRVCSDGPVFTKSELRRVKDEFGIFKRDASGRKVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDA8</accession>
    <name>A0A133VDA8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nse4_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000031">
        <property type="protein sequence ID" value="KXB04432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04432">
        <property type="protein sequence ID" value="KXB04432"/>
        <property type="gene ID" value="AKJ48_02610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4_C" evidence="2">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="265" mass="30651" checksum="7353B91A29C268EB" modified="2016-07-06" version="1">MVSKKKRELMLRIIDLAKSVREKGIDPFEVEVEELFQRLREIFPEVEDPEELLLDVRAVLGLTDVISQQGDWIKHKSSLLYFDPMLVQWKLRELSGKQLARVLTKSWHPIVGLECISQPGIRESVDYWTNLAPLSERGIELETTEVSPGEVGLDALSELGVESEKDFNELIEKTWRELKEIAGEEERVSYWDFVDAENFHKTVRRAWLVSFLVSYGYATLEIQPLEEEIIIKPRKERKTPSEEVSSSIPVSISHSDWKARRTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDC1</accession>
    <name>A0A133VDC1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrI</name>
        <name evidence="10" type="ORF">AKJ48_02635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000032">
        <property type="protein sequence ID" value="KXB04417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04417">
        <property type="protein sequence ID" value="KXB04417"/>
        <property type="gene ID" value="AKJ48_02635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="8">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="9">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="156" mass="17693" checksum="7BA1BDFA77E6EB0D" modified="2016-07-06" version="1">MREPDRKLRVSKIESGTVIDHIPHGKAWAVLRILDIPGREDATVSILMNVSSEKHGRKDLIKVENRKLTKREVNEIALIASKATINIIEDYQVIEKRRVDLPEAIKGIVRCSNPDCITNASEPVESKFEVVNESPVTLRCSYCERVTGEEELLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDJ9</accession>
    <name>A0A133VDJ9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">AKJ48_02315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04519">
        <property type="protein sequence ID" value="KXB04519"/>
        <property type="gene ID" value="AKJ48_02315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="183"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="316"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="435" mass="51494" checksum="93804CD95922D1F4" modified="2016-07-06" version="1">MKRVLRQNLRGLNCEDYGILRSMCRLSKNLYNSTLYEVRQHFFDNGEYLSYYNVWRRLKGDFNYELLPSQAAQHTVMHVHQAFRSFFKLVKMKRRGEYEGETRPPGYLDKDGFFSLNLPNQSFQVKEDYIRIGIPQSFRREFNCERTEIRFPFTYEEVKAKEIKQLQVIPKAKAQYFEYRLIYEEEKTRIETEKGTWLSIDLNVDNLAVCGDHSGRSFILDGRKLKSINRWYNREIARLQSIKDKQGIQENTRRTNKLYRDRRNKIHDYFNKAVHWILEYCKANKIELVLVGDGKEWKQESEMGDKNNQNFMQIPFDLFKRKLKAKLELHGINFELVEESHTSKCSFSDGEPVEHHEEYVGTRVKRGLFKTSNGILVNADVNGYLNIARKYLEENGEKGKLKTLKGVESSGVVATPRRIREPFKVPAFPKAPYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDK2</accession>
    <name>A0A133VDK2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="10" type="ORF">AKJ48_02365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="LHYB01000027">
        <property type="protein sequence ID" value="KXB04501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04501">
        <property type="protein sequence ID" value="KXB04501"/>
        <property type="gene ID" value="AKJ48_02365"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.336"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KXB04501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="293" mass="31370" checksum="ED26719B4697981E" modified="2016-07-06" version="1">MTFEGTMTALITPFDENGDFDEEGFRENIKSQIDGGIDGIVPVGTTGECATLSYEEHEKVVEVAVDAADGKVPVVAGTGSNSTKEALMLTNYAAEAGADGVLLVAPYYNKPTQRGLYEHYKKLAEEVNIPQVIYNIPSRTGRNIEAETLIKLSELENVVGVKEASGDLNQVMKIARGSGEDFDILSGDDSLTLPILSLGGVGAVSVASNLVPGKISDLVSSYLEGDVEKARDIHFELMPLFKALFIETNPGPIKAAMNILGKPAGKPRLPLVEAESETKQKLREVMSELGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDM8</accession>
    <name>A0A133VDM8_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">AKJ48_02200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04558">
        <property type="protein sequence ID" value="KXB04558"/>
        <property type="gene ID" value="AKJ48_02200"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.301"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KXB04558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="251" mass="27325" checksum="CCCE61BE23789DE9" modified="2016-07-06" version="1">MVSFAPQLKRSIAIAKKNLRIYYVKGPVIIFGLLLPFFFFLAFWLGRDMSSIMLGTGLVGMAMWFASTSISPVITSWETRTKTLERLISSPIGLSGILFGDMLASALIGILITIVPLSIALVVLDMTLVYPLVLALGLVLGSFCFSAIGVLMAALPTDTTADVMMLSSLVKFPIIFVSGIFIPVSQLPGWGQAISHLSPLTYLTDLVRWTFGSNGSFWPSPLQNLLILTAFLMGFSALAVFSHRKTLPKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDN6</accession>
    <name>A0A133VDN6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000026">
        <property type="protein sequence ID" value="KXB04517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04517">
        <property type="protein sequence ID" value="KXB04517"/>
        <property type="gene ID" value="AKJ48_02345"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.332"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026453">
        <property type="entry name" value="PGF_pre_PGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04213">
        <property type="entry name" value="PGF_pre_PGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="653" mass="75157" checksum="C15F29F8FC3A8BAB" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDQ3</accession>
    <name>A0A133VDQ3_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">AKJ48_02085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04570">
        <property type="protein sequence ID" value="KXB04570"/>
        <property type="gene ID" value="AKJ48_02085"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.276"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KXB04570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="685" mass="77266" checksum="87CACF5190557B38" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDQ4</accession>
    <name>A0A133VDQ4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NifU_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000025">
        <property type="protein sequence ID" value="KXB04534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04534">
        <property type="protein sequence ID" value="KXB04534"/>
        <property type="gene ID" value="AKJ48_02300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="115" mass="12276" checksum="F03A1B701B7A0532" modified="2016-07-06" version="1">MDDADVTVQEGDPTCGDMIQLQLKIEDNVIEDVKFLSFGCAANIATGSALTEMVKGKTLGESKKVTMKDIKEEVGGLPPVKMHCAVLATRALESALKKAIEMYESGEGSESEPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDR4</accession>
    <name>A0A133VDR4_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">AKJ48_02040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="LHYB01000021">
        <property type="protein sequence ID" value="KXB04593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04593">
        <property type="protein sequence ID" value="KXB04593"/>
        <property type="gene ID" value="AKJ48_02040"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.266"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KXB04593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="331" mass="37043" checksum="2FBA51466BC91784" modified="2016-07-06" version="1">MSFPKARLRRLRKTANIRRLIKNVSLSKDDLLYPIFVKEGIKEKSEIKNMPGQWHHSLKTLNEVIDDCESAGIPGVIIFGIPENKDETGSEAFNDQGIVQTAVSRIKSESSLAVFTDVCLCQYTIHGHCGILDESGLNNDKTLEVLRKTSVSHARAGADFVSPSGMIDGQVKEIREALDNEGFGDVGIMSYSAKFASNFYGPFRDAVESSPKKVEGLPHLGDRSTYQMDFKTSEQPMREIKLDIEEGADIVMVKPALPYLDVIREARQTFDVPISAYQVSGEYTMIKRLSENDEDYEKRLFLESLNSIKRAGANFILTYGALDVSRWLSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDS0</accession>
    <name>A0A133VDS0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable porphobilinogen deaminase</fullName>
            <shortName evidence="4">PBG</shortName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="4">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hemC</name>
        <name evidence="7" type="ORF">AKJ48_02035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="4">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="LHYB01000021">
        <property type="protein sequence ID" value="KXB04592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04592">
        <property type="protein sequence ID" value="KXB04592"/>
        <property type="gene ID" value="AKJ48_02035"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.265"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="5">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="6">
        <location>
            <begin position="218"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="283" mass="30746" checksum="4E882D5F3ED665BD" modified="2016-07-06" version="1">MKLRIGTRGSNLALIQTWSVGDQIKTIKPEVEIELIIVKTSGDLRRKIKGSGIFAKEVNQAVLDGDADIGVHSLKDLPTKLPEGLSLVSIPERLTPNDVLITPNGARLSDLPSDSIIGTGSPRRRAEISHLRTDLKFKKIRGNVDTRIKKVESGDFDGLITSMAALERLGLEEKASQKFDFEEVVPAAGQGSLGVVGRKDDEKTSFLGEISDEKARLESICERAFLRELGLGCKAGAGVLARAKDNEIKTLAVLHDSEGRHLVKLRGSDPVELGEKAAREVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDS8</accession>
    <name>A0A133VDS8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_02195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04557">
        <property type="protein sequence ID" value="KXB04557"/>
        <property type="gene ID" value="AKJ48_02195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="66" mass="6964" checksum="C93E0C5A07282698" modified="2016-07-06" version="1">MGDNYAASPILVDIAAEFEVSIGTAAMTVTAYMLPFGLFTIFFGPLADRFGKVRVITTAALGTAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDU1</accession>
    <name>A0A133VDU1_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">AKJ48_02185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000023">
        <property type="protein sequence ID" value="KXB04564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04564">
        <property type="protein sequence ID" value="KXB04564"/>
        <property type="gene ID" value="AKJ48_02185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="260"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KXB04564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="357" mass="38502" checksum="2D42AAEC2F21023C" modified="2016-07-06" version="1">MTRLGNGEDGTSSVSESKFQRLKRRVDSLENGSMNEPRTVNATENLWSVDEIYRLVENSVVEIRVTKSSEGFFETEQTGLGSGFVYDKSGHVITNQHVVEGADEVLVRFYNGETVKAKVIGSDSYSDLAVIKVDTSELDCRLDPVSLGDSSVLETGDPIVTVGNPYGLEGTTTFGIVSQTGRVLSSETRYLIPGVIQIDAPINSGNSGGPLLNMAGRVVGVTTAIQSETGTFSGIGYAVPSDLMNRVVESLIEEGEYSYAWLGISGQKVTYETAQRRGLERTRGFLVKNVSQDGPSSDRVMENDVILRIDGREVMGVGDILSYIGVEKAPGEDVSLKVLRDGEETVVTVKLGVRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDV2</accession>
    <name>A0A133VDV2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_02110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000022">
        <property type="protein sequence ID" value="KXB04574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04574">
        <property type="protein sequence ID" value="KXB04574"/>
        <property type="gene ID" value="AKJ48_02110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="118" mass="13301" checksum="F1EDC13CB2DDDEEC" modified="2016-07-06" version="1">MDWLAVLMPGEFLARRYDPSYLKFAMKAKNRGTIAKIAAIMEYAFVVMVGLISGIFSFYWPILVLLVAYPFVVIGEPWVWRKYYGEIAEGVGVTGAFLANLDMLYLFTIGYLVGALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDX9</accession>
    <name>A0A133VDX9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">AKJ48_01850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000018">
        <property type="protein sequence ID" value="KXB04641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04641">
        <property type="protein sequence ID" value="KXB04641"/>
        <property type="gene ID" value="AKJ48_01850"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.199"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KXB04641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="535" mass="56912" checksum="FA905C26D630E82C" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VDZ7</accession>
    <name>A0A133VDZ7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ORF">AKJ48_01825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04672">
        <property type="protein sequence ID" value="KXB04672"/>
        <property type="gene ID" value="AKJ48_01825"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.195"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00285">
        <property type="entry name" value="TIGR00285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="7">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB04672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="95" mass="10145" checksum="F15B1DF2BE1A3157" modified="2016-07-06" version="1">MAEEESNENVVFIGNKPVMNYVLAVITQINEGVGEVVLKARGRAISRAVDVAEIVRNRFLQDLAIQNIETGTEEIEGESGTSNVSTIAISLGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE03</accession>
    <name>A0A133VE03_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04661">
        <property type="protein sequence ID" value="KXB04661"/>
        <property type="gene ID" value="AKJ48_01755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="117"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="286"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="382" mass="42661" checksum="B1CB183C8D596374" modified="2016-07-06" version="1">MTLVVPVGPQHPALEEPEHFRITVEGEEIVDADVRLGYMHRGIEKAFQEQNYQRGVYLSERICGICSGIHTLVNVETAEQLAGIEAPPRAKYIRTIVAELERIHSHLLWAGIAAHEIGFMTLFMLTWRDRELVMDLLEMISGNRVNYAANTIGGVRFNINPTQAVKIMDGLDELEKHGKHYADVFPSDPTILARCEGKGILSKEDGLKLCAVGPTARASGIDVDLRRDDPYAAYDEIDFEVITAKEGDVLANAKVRLLEILESVKIIRTALERMPSGRLRVKAPKKFPEGEATNRGEAPRGELFYHFKSRGGEKPYRVKVRTPTLANMPSALEKLKGETLTEVPIVVASIDPCFNCTERVTVVDSETGDSRIMTEEELRELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE48</accession>
    <name>A0A133VE48_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000017">
        <property type="protein sequence ID" value="KXB04674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04674">
        <property type="protein sequence ID" value="KXB04674"/>
        <property type="gene ID" value="AKJ48_01835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="73" mass="8277" checksum="D68A83030ED685FB" modified="2016-07-06" version="1">MISTAGWIVVGIVGLAFAVVLAWLGTLWISTRTSREMSEMFKPRATVEELDEIRRELEEIKRNLNEIQDELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE53</accession>
    <name>A0A133VE53_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04719">
        <property type="protein sequence ID" value="KXB04719"/>
        <property type="gene ID" value="AKJ48_01675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="583" mass="67508" checksum="4025C8081C3A1383" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE63</accession>
    <name>A0A133VE63_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000015">
        <property type="protein sequence ID" value="KXB04715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04715">
        <property type="protein sequence ID" value="KXB04715"/>
        <property type="gene ID" value="AKJ48_01655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="340" mass="38533" checksum="FB44A0C3EF3F27A6" modified="2016-07-06" version="1">MKITATENFKDRLLRCSPKVAVETLKAVLPLRKRTVSKAASKLNLSEGTIYNRLKDLKILGLLESEEGKIILRDQATIKDICVGKNYDSLKKSFLKLSYSGIIDELDKDGVRVEDLGRDIALKSTSIASDPQTVETYGTIFAKWADFFSLASYDHQNKILYPPDVDISKAKKRTTKLRIPKATVGEFFDLLPVLTRNPNSREEIAERLSISPTSVDKHLSTAYLWGLAERKGNQYQLTESGKKFMSKSEGNKKAYIRKKLKSLPIFQAFVYFLRQGNLPQESVNKISKRYTKGWKESYAKTISKKIVSWGKYADILEGRGDEIKLTVKGVKLDPQLPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-08-12" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE65</accession>
    <name>A0A133VE65_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein AKJ48_01695</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04687">
        <property type="protein sequence ID" value="KXB04687"/>
        <property type="gene ID" value="AKJ48_01695"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.167"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="282" mass="30220" checksum="30147BCC4B7E7B0C" modified="2016-07-06" version="1">MANVRSPAVAGQFYAGTESSLQRQIEECYTHEHGPGRIPEVGAGPRNILGLVSPHAGYPYSGPVAAHGFARLAEDGKPDSFILLGPNHQGIGSGVSIMTTGKWSTPLGELETDNPLAEAIRDSASIIDEDEVAHSREHSVEVQLPFLQHLFGNEFKIVPICMMMQDKETNEEIGQAIAESASEEDVVIIASTDLTHYEPQEAAVSKDGKAIDEILKLDPQGLIRTISDENISMCGYGPVSAMLYAAKELDAQKANLLKYATSGDTSGPMPQVVGYGSIEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VE74</accession>
    <name>A0A133VE74_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps2</name>
        <name evidence="7" type="ORF">AKJ48_01690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000016">
        <property type="protein sequence ID" value="KXB04697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04697">
        <property type="protein sequence ID" value="KXB04697"/>
        <property type="gene ID" value="AKJ48_01690"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.166"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_S2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_S2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_S2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="PTHR11489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KXB04697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="194" mass="21694" checksum="D16980A20DB3D61F" modified="2016-07-06" version="1">MEQYLASGVHIGTRQKTGAMNPYIYRVRPDGLFVLDVQQADERIDLAARLIASFEPEDTYVVSARQYGQRPVSKFGEVTGARISAGRFIPGTFTNPSYENYIEPKLLVVTDPVADEQPLAEAATIGMPVIGLCDTDNDTRNIDLVIPTNNRGRKSLALVYWLLARQVLRERGELAPGEELDVSLEEFETKFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VED1</accession>
    <name>A0A133VED1_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000013">
        <property type="protein sequence ID" value="KXB04757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04757">
        <property type="protein sequence ID" value="KXB04757"/>
        <property type="gene ID" value="AKJ48_01495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="263" mass="30571" checksum="D26331B4DE6F0F1F" modified="2016-07-06" version="1">MKKRDALIQYISKHIDKIIIIASYVMLLLLLLTLIPGVLYKERLIREGRWQENRKISNDYFTITYALNTGEHAPLISDQEGNRLITINGFKSNIKIDNRESRSFWNHEFRNVVEGDTTVRHNVLWDNYQLKQITTLSDNTVVIDYKIKSCGGEDNFDLTLNLWYEYQASSLLKIDNAYVNDNYRGENQEDNQLKPTHVVLIQTDLKPENIENAPYWAKLTYSSENLTVETTWKDLVETRISYVSWREKFETGESSGETSGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VED6</accession>
    <name>A0A133VED6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_01365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04806">
        <property type="protein sequence ID" value="KXB04806"/>
        <property type="gene ID" value="AKJ48_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="159" mass="17195" checksum="DE52D9F0538E7409" modified="2016-07-06" version="1">MESGVRVAVGFWGLVGFWLVKVLILALICFFLGWLGLRALDALTPRIHEREEIGKDPIATGLFISGFLIYVALVIHGAVTTLPGGSFVGSLFMRRLGIIAIAFVVSLLLAIGLFNLLDRLTPQIPFAKLRHSSLGTGLYVFGYLIFLGLITNAAFAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEE2</accession>
    <name>A0A133VEE2_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name evidence="3" type="ORF">AKJ48_01270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000010">
        <property type="protein sequence ID" value="KXB04823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04823">
        <property type="protein sequence ID" value="KXB04823"/>
        <property type="gene ID" value="AKJ48_01270"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.904"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="342" mass="36888" checksum="0FE20308F016CE56" modified="2016-07-06" version="1">MSVKVAIVGASGYTGGELLRLIINHGDAELLGVYGKKSVGQPVAELHPNLEGIIDLTIEEADYGKISGEADLVFTATPHGVAMKFVPEILDGGAKVIDLSADYRLDDPKVYEEYYVPHESPDLESVYGLPELYRKEIKKADLVANPGCYPTAAILELAPLLKEKLIDLDHILIDAKSGTSGAGAKPSKKLHHPNCGENILAYNAATHRHAPEIDQELGKIAGEEIGTHFTPHLIPVVRGIFSTSHVFLRESSDEGKILDLYRGFYQDEPFVRVLEDLPQTGSVLGSNYCDIGIELDEGTGRLIIGAAIDNLVKGASGQAIQNMNMMLGLDEAEGLRGVGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEE7</accession>
    <name>A0A133VEE7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000011">
        <property type="protein sequence ID" value="KXB04801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04801">
        <property type="protein sequence ID" value="KXB04801"/>
        <property type="gene ID" value="AKJ48_01340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="179" mass="19059" checksum="011FDD7BFDF0471E" modified="2016-07-06" version="1">MKCQIGVIGSSEKEARGKQKAKSIGREIAKAGCHLLTGGCTGLPYAAIEGAKEEGGFTVGISPAIDQEEHLKKYGYPIEGHDLMVYTGFGYKGRNVILVRSCDGVVATSGRMGTLNELTIAHAEGKVMGLLKGVSGAGEEFEKLAKKLGRPEGKIITSENPKKLVQKVLQKLDEKTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEG7</accession>
    <name>A0A133VEG7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04848">
        <property type="protein sequence ID" value="KXB04848"/>
        <property type="gene ID" value="AKJ48_01200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="94" mass="10535" checksum="D8398C2ACC2B2263" modified="2016-07-06" version="1">MTSTTRRIGTQPLEEKLAPVNETTWKMIQERWNDIRSACPDRHDGRCVITGRVCTPESCPKLGRQVELSQFVEGQLEGRQAEDAGGEIAHWAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEH7</accession>
    <name>A0A133VEH7_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04858">
        <property type="protein sequence ID" value="KXB04858"/>
        <property type="gene ID" value="AKJ48_01190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="90" mass="10322" checksum="6747344F730BF01C" modified="2016-07-06" version="1">MPTEKTPYLIWKGSEAWVAKDVRTGVASQGETRQEALENLDEAISLHEGEGSESIETWEEEREFLKELGIDPEEVKRARKSSQELPEFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEK2</accession>
    <name>A0A133VEK2_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_01215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000009">
        <property type="protein sequence ID" value="KXB04851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04851">
        <property type="protein sequence ID" value="KXB04851"/>
        <property type="gene ID" value="AKJ48_01215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB04851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="61" mass="6956" checksum="BA02C35A02E8BD4E" modified="2016-07-06" version="1">MKLIIRRDATIGGQDFHAEQESRVKRDMDWSFARDVSTTGIGMFASERSVVKRQGEVKNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEK9</accession>
    <name>A0A133VEK9_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04876">
        <property type="protein sequence ID" value="KXB04876"/>
        <property type="gene ID" value="AKJ48_01110"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.781"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="5">
        <location>
            <begin position="130"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="380" mass="42688" checksum="2880593656F91173" modified="2016-07-06" version="1">MKVNTTPSEGHSERGTINLFIGPQHPGSGHMRLEVVLDGDVVVDITPDIGWVHRGVEKVAETKKFIQVIPLVERPAILDSANMNVGYVRAVEKILDSEVPVRARYIRTLICELNRIASHLYGIGILGNMIGTSTLYMWSFADREIILELLQEFTGARLTHSFFLPGGVRDNPPKTFMNELEQGLKYVENRLPDYKALTFDNPAVRGRLEDVGIINKKKAIKLGITGPNLRASGVKYDARMIGDYGAYDELGFKPATRKDGDCFARLMIRIDEIRESIKLVRKIIREMPKGKIMSEETRSINKLVTMDFPEGEAFSRVECGRGELTTFLISDGKDKPNRLRVITPSFRNVIAFREAIVGHRLADIPAVYGSLDYFPPEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEN7</accession>
    <name>A0A133VEN7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex1_30kDa domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_01115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000008">
        <property type="protein sequence ID" value="KXB04877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04877">
        <property type="protein sequence ID" value="KXB04877"/>
        <property type="gene ID" value="AKJ48_01115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="2">
        <location>
            <begin position="26"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="150" mass="17440" checksum="9DB40071CC326E3E" modified="2016-07-06" version="1">MTKRKIRGIPVPKKSKGKKTRQVREISPNELRGEIEKLVDNGFDHLKSLTGVDRPENDQIELIYHLSSYSNSDLQRVIIEIRVRIDKDNPRIESISDIWPSSKYIEAETRDLLGVTFEGNKIRSPLILPEELEDEHPLRKDFKIPEEGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEP5</accession>
    <name>A0A133VEP5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_01020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000007">
        <property type="protein sequence ID" value="KXB04901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04901">
        <property type="protein sequence ID" value="KXB04901"/>
        <property type="gene ID" value="AKJ48_01020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="5">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB04901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="71" mass="7653" checksum="85FD705609C8D44D" modified="2016-07-06" version="1">MTELPVAAVDRIIRKAGARRVSEGAAEALAEVLEERALSIAGEASRLAEHAGRKTVRDVDIRLASRRSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2020-10-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VES8</accession>
    <name>A0A133VES8_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000006">
        <property type="protein sequence ID" value="KXB04927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04927">
        <property type="protein sequence ID" value="KXB04927"/>
        <property type="gene ID" value="AKJ48_00935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB04927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="320" mass="35497" checksum="DEE0D007BC908EE1" modified="2016-07-06" version="1">MSPKKILTITIIIILAIGLLWITKPWQKIGGSGKGASPTASFSYSVDNQDSLKVHFTNESSDLDNDITSYSWSFGDESTSTSVDPTHAYSTGGTYTVELMVMDSEGNSDTHSRSVTVKKVPLGYTLFRYAASFQYLNSEDNEPIGDEIFIVYPCPNVDNEPVVANENFTWQLLAHYTENGENVWQVEVDNGTPALMVEPRENAPNYSPPDILNTSHGPKVWLHLIHSGLNSRDALFQNEIARIEAEFLVPDENADKVTLVDNQGGIYFNAGPYSEGYKPIRYSVEVSLSKWVGDTFESLGTFSAIADNLPEYAWIELEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEW7</accession>
    <name>A0A133VEW7_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB04983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB04983">
        <property type="protein sequence ID" value="KXB04983"/>
        <property type="gene ID" value="AKJ48_00615"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.388"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="52"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB04983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="432" mass="49268" checksum="AC30177B5530CBAC" modified="2016-07-06" version="1">MYVKYVRDPVLGYIGMTEAEKHIIDTWPVQRLRGISQLSTTGITYPGGVHSRFSHALGTMHLAGQMVGSLRTGVEISDEEWQLVRLAGLLHDIGHGPFSHSYEEVLSKYMDMTHEDLGEKIVKESELADEITAQGHDPKEVADLIFGGGGKPYLKQIVASQVDADKMDFLLRDAYFTGVEYGQIDVHRLIQAMEVVENDIAIDMKALYALEAFMISRYEMFLAVYYHHSVRAAEIMLRKAMEHAHEILGLTNFKDISEFLQLDDAYVVTALRRLNPEDFEGEDRKEAERVREIMRKIGRRELLKSAYRREVHIKDEYVANLLGDESVRHQKEEQIAKKAKVDPEYVIVDVPTLASMPYYPREIAPMEVPIFKIGKNEEKELVPLSEHSRLVNVLKGYIDIIRVFTLPEYRDAVGDAAEEVFKKLPLAAQISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VEZ3</accession>
    <name>A0A133VEZ3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000004">
        <property type="protein sequence ID" value="KXB05000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05000">
        <property type="protein sequence ID" value="KXB05000"/>
        <property type="gene ID" value="AKJ48_00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="70" mass="7618" checksum="5F817A7D501CD156" modified="2016-07-06" version="1">MDWANILIIIGKIIAAIILAIIIGGSGLFGYIAWKAEARKWAGGMFGILVACVFLFYWLIAATFGLPFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF08</accession>
    <name>A0A133VF08_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05028">
        <property type="protein sequence ID" value="KXB05028"/>
        <property type="gene ID" value="AKJ48_00480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="175" mass="21041" checksum="334C3A41C217FF10" modified="2016-07-06" version="1">MSRTDTIKQRRVDVYLDSMERKEEWEEAAREMGMSLSRFVQHCVEDSLGRGGPDLVKPSLVEEKEEEIEELEDSISELRRKIDRKNKVIERLEDDLRKRRMEPFLDGEFEGVRRYEKELIEILKENGWHSDSEILRRLKVNLKDEETLRAIRYQLERLERYGLVKTGRSGWKWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF13</accession>
    <name>A0A133VF13_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">AKJ48_00505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05033">
        <property type="protein sequence ID" value="KXB05033"/>
        <property type="gene ID" value="AKJ48_00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KXB05033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="361" mass="41740" checksum="8CAFB289DC0076BC" modified="2016-07-06" version="1">MIKNGWLDYLWMPLSVSAILILIIIYRSGLLHEKGDEERFSESWAGVLNLSVMSILLTFLSYGIAWGVSSVIVEAYDWPVFPLLIGLFFFGLFSSTLFFRYVLNIGKVSLIEKNFKKLWEELDKFRKSRESEDEAKKKKEEAIRKLMEGINKKLKNLEDLPSKKAIGKLVKKIVRRSAEETEETPPESVVEKIFEDGTANELADIIADRVEVKIEGSGRYATGQTFQEESKQDFEGEGFEVETYKSGRRRADYILRIDDRVVACAGVRRRNVKKSTTLTKDDFKAGLSYAEKQGVPFIIWWWNPVTNRRWANVVEVEDLANFKGPVPTWLWHEELDPEEERERKKSQREAKRRIRELAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF16</accession>
    <name>A0A133VF16_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">AKJ48_00520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="LHYB01000003">
        <property type="protein sequence ID" value="KXB05036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05036">
        <property type="protein sequence ID" value="KXB05036"/>
        <property type="gene ID" value="AKJ48_00520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KXB05036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="219" mass="24703" checksum="8626368227BB93D2" modified="2016-07-06" version="1">MGYVPLLIDLAGKVVLVLGGGPVGERKAELFSKTDAKVQVFGLDFTDKLKEMATEDSRGKIELVKGEIKTEKAESSIRNADLVVIATDDNDLNDELADISEREGKLVNKADDLSTQLMIPSILRKGDVIISISTGGKSPAMCKFLRQKIEDWLDESYVEMVRIQEEMKKELKKGVENLERRREILWSLIEDGEIWDLLKSDPERAMKIAVKKARKRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF68</accession>
    <name>A0A133VF68_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">AKJ48_00060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05098">
        <property type="protein sequence ID" value="KXB05098"/>
        <property type="gene ID" value="AKJ48_00060"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.12"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KXB05098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="194" mass="20963" checksum="0014DE85ED7DFF8D" modified="2016-07-06" version="1">MLRFTRSELSHIAISILVLTIAVSGIGPNWPGLTAIGRNIAAVSLPLVAGFFAHEISHKYTAIRYGYWSVYRMWPLGLLIALIFGIISSGRVLFAAPGAVMILTPHITRKENGLISLAGPLANIVVAIAFYPLTYVGGLVGLMGSFGVFVNLWLAFFNLLPIGPLDGSKLIQWNPMVWIGLEVVLAASLFTIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF74</accession>
    <name>A0A133VF74_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleoside-triphosphate reductase</fullName>
            <ecNumber evidence="1">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.2" evidence="1"/>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05091">
        <property type="protein sequence ID" value="KXB05091"/>
        <property type="gene ID" value="AKJ48_00015"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.3"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="603" mass="69267" checksum="C3C24DAE57D2799F" modified="2016-07-06" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF85</accession>
    <name>A0A133VF85_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05102">
        <property type="protein sequence ID" value="KXB05102"/>
        <property type="gene ID" value="AKJ48_00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="156" mass="17398" checksum="3E5A7423A887F21B" modified="2016-07-06" version="1">MKIAIQGLGEVPNPARLVLEEEKPDKSYVIASDYQLDYVCERRDFKEPNKEVIKTAAEEAGTELVIKKCDPFDLDEITDTIAGILEEISDEADEVLVNYTGGSANLRVVLGFTGVTLTRLCPTKIIYAVGYPSGPKIVTDNAEKLRDIYRRLNKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VF94</accession>
    <name>A0A133VF94_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ORF">AKJ48_00155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05113">
        <property type="protein sequence ID" value="KXB05113"/>
        <property type="gene ID" value="AKJ48_00155"/>
    </dbReference>
    <dbReference type="PATRIC" id="fig|1698277.3.peg.28"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6 7">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KXB05113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="261" mass="28362" checksum="79D160A2F76C7FF1" modified="2016-07-06" version="1">MLIFIGLGLQGKGLTLEGLEEAQNADRAYVELYTSLIPDLDLDALSEKIGKKIKVLEREDVEEHPDEILETAKSEKVAFLVPGDPMVATTHVDLRLRAEKAGIETRIIHGASIEIAAPGLAGLQSYKFGRSATIPLPEKPSETPYEVLVQNQEDGLHTLLLLDIEAPEERYLTANEAMEIMLDLESKGGKNVFTQETLVAVIARAGSEKPTVKAGKVGDLIDFDFGSPPHVLIVPGKLHFLEAEALQVFGGAPEEVEGYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA3</accession>
    <name>A0A133VFA3_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05126">
        <property type="protein sequence ID" value="KXB05126"/>
        <property type="gene ID" value="AKJ48_00240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="162" mass="18068" checksum="1202E63C5B41DDD6" modified="2016-07-06" version="1">MIVSDSSPLIYLAKIGRLTLLKDLYKEVIVSDGVIGEVLIKGKPGTTEIEKALDEGWSRRVKAKIDFDPESDGISKVDAELICLARDKGLQLLTNDRALFYCAKSHGVKSEWFTLMIIKATKSDLLSPDDAEELLTELVHSGLRIRSEVLAELVRQIRDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFA5</accession>
    <name>A0A133VFA5_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05123">
        <property type="protein sequence ID" value="KXB05123"/>
        <property type="gene ID" value="AKJ48_00225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="129" mass="15241" checksum="E57960B8561A8ED8" modified="2016-07-06" version="1">MGIHRWDGYVDYYEKAVNTIVHLLDNYCLDCHRGSFQIECPFEAEKIRVECGIGSALIQCIEYVENNDYLDDEEMKRKLDQIASLARELKDKPWEPIPEEERNEEKFAPILRRNSKFNQLKELATQISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFC0</accession>
    <name>A0A133VFC0_9EURY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TrmB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">AKJ48_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05139">
        <property type="protein sequence ID" value="KXB05139"/>
        <property type="gene ID" value="AKJ48_00280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KXB05139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="285" mass="32456" checksum="48867E8F0F6F504D" modified="2016-07-06" version="1">MATVGEEQIRLLKELGLKEYPAKTLAHLIELGESKAPELSSASGVPKARIYGVLDDLADRGLVEVKPGRPAKYRPKSPNEIIERIIHNKKARMDKEIERIEDLRGDFEPVFQPIYESAVKKTREPLLKTVSVGEPAEEETRLMYEEAEKEIDIVSRAMEWLPEVKESLEEALKREIQVRVLLLAPDQLEDEEDKTLQEATRKTLEEELSGVKVRFSKFILPLRGSIIDPSYDYSSGKAIFLVEERGVPFTLRDAAITENPSLVAGMKRYFDLIWEHESLGIKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-07-06" modified="2019-12-11" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A133VFC6</accession>
    <name>A0A133VFC6_9EURY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">AKJ48_00235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">candidate division MSBL1 archaeon SCGC-AAA261O19</name>
        <dbReference type="NCBI Taxonomy" id="1698277"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Euryarchaeota</taxon>
            <taxon>candidate division MSBL1</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2016" name="Sci. Rep." volume="6" first="19181" last="19181">
            <title>Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine pools of the Red Sea.</title>
            <authorList>
                <person name="Mwirichia R."/>
                <person name="Alam I."/>
                <person name="Rashid M."/>
                <person name="Vinu M."/>
                <person name="Ba-Alawi W."/>
                <person name="Anthony Kamau A."/>
                <person name="Kamanda Ngugi D."/>
                <person name="Goker M."/>
                <person name="Klenk H.P."/>
                <person name="Bajic V."/>
                <person name="Stingl U."/>
            </authorList>
            <dbReference type="PubMed" id="26758088"/>
            <dbReference type="DOI" id="10.1038/srep19181"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">SCGC-AAA261O19</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LHYB01000001">
        <property type="protein sequence ID" value="KXB05125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KXB05125">
        <property type="protein sequence ID" value="KXB05125"/>
        <property type="gene ID" value="AKJ48_00235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000070076">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KXB05125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000070076"/>
        </source>
    </evidence>
    <sequence length="120" mass="14147" checksum="44BFB55EAF885BA7" modified="2016-07-06" version="1">MKYNEGLIDEWLSFAPKYHLTQSEIMINNGEDLRKSTYALSRAILQTARGVDWKEDKNTSSSYKSITQSIKKMRHPQSSLVKWALEKRQNNFKSTTRETKTKLKPARKFLDTIMKKYEIK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>