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         <PDBx:journal_abbrev>Nat. Struct. Mol. Biol.</PDBx:journal_abbrev>
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         <PDBx:title>Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.</PDBx:title>
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         <PDBx:item>_citation.pdbx_database_id_DOI</PDBx:item>
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      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="6" revision_ordinal="2">
         <PDBx:item>_citation.title</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="7" revision_ordinal="2">
         <PDBx:item>_citation.year</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="8" revision_ordinal="3">
         <PDBx:item>_citation.journal_abbrev</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="9" revision_ordinal="3">
         <PDBx:item>_citation.pdbx_database_id_PubMed</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="10" revision_ordinal="3">
         <PDBx:item>_citation.title</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="11" revision_ordinal="3">
         <PDBx:item>_citation_author.name</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="12" revision_ordinal="4">
         <PDBx:item>_citation.journal_volume</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="13" revision_ordinal="4">
         <PDBx:item>_citation.page_first</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="14" revision_ordinal="4">
         <PDBx:item>_citation.page_last</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="15" revision_ordinal="5">
         <PDBx:item>_pdbx_audit_support.funding_organization</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
      <PDBx:pdbx_audit_revision_item data_content_type="Structure model" ordinal="16" revision_ordinal="6">
         <PDBx:item>_reflns_shell.percent_possible_all</PDBx:item>
      </PDBx:pdbx_audit_revision_item>
   </PDBx:pdbx_audit_revision_itemCategory>
   <PDBx:pdbx_audit_supportCategory>
      <PDBx:pdbx_audit_support ordinal="1">
         <PDBx:country>United States</PDBx:country>
         <PDBx:funding_organization>National Institutes of Health/National Institute on Aging (NIH/NIA)</PDBx:funding_organization>
         <PDBx:grant_number>NIH NIA AG029430</PDBx:grant_number>
      </PDBx:pdbx_audit_support>
   </PDBx:pdbx_audit_supportCategory>
   <PDBx:pdbx_database_statusCategory>
      <PDBx:pdbx_database_status entry_id="5WHP">
         <PDBx:SG_entry>N</PDBx:SG_entry>
         <PDBx:deposit_site>RCSB</PDBx:deposit_site>
         <PDBx:pdb_format_compatible>Y</PDBx:pdb_format_compatible>
         <PDBx:process_site>RCSB</PDBx:process_site>
         <PDBx:recvd_initial_deposition_date>2017-07-17</PDBx:recvd_initial_deposition_date>
         <PDBx:status_code>REL</PDBx:status_code>
         <PDBx:status_code_sf>REL</PDBx:status_code_sf>
      </PDBx:pdbx_database_status>
   </PDBx:pdbx_database_statusCategory>
   <PDBx:pdbx_entity_nonpolyCategory>
      <PDBx:pdbx_entity_nonpoly entity_id="2">
         <PDBx:comp_id>HOH</PDBx:comp_id>
         <PDBx:name>water</PDBx:name>
      </PDBx:pdbx_entity_nonpoly>
   </PDBx:pdbx_entity_nonpolyCategory>
   <PDBx:pdbx_entity_src_synCategory>
      <PDBx:pdbx_entity_src_syn entity_id="1" pdbx_src_id="1">
         <PDBx:details>Synthetic peptide NFGTFS corresponding tosegment 312-317 of TDP-43</PDBx:details>
         <PDBx:ncbi_taxonomy_id>9606</PDBx:ncbi_taxonomy_id>
         <PDBx:organism_common_name>Human</PDBx:organism_common_name>
         <PDBx:organism_scientific>Homo sapiens</PDBx:organism_scientific>
         <PDBx:pdbx_alt_source_flag>sample</PDBx:pdbx_alt_source_flag>
         <PDBx:pdbx_beg_seq_num>1</PDBx:pdbx_beg_seq_num>
         <PDBx:pdbx_end_seq_num>6</PDBx:pdbx_end_seq_num>
      </PDBx:pdbx_entity_src_syn>
   </PDBx:pdbx_entity_src_synCategory>
   <PDBx:pdbx_nonpoly_schemeCategory>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="1">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>101</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="2">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>3</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>102</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="3">
         <PDBx:auth_mon_id>HOH</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>103</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
   </PDBx:pdbx_nonpoly_schemeCategory>
   <PDBx:pdbx_poly_seq_schemeCategory>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASN" seq_id="1">
         <PDBx:auth_mon_id>ASN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>312</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PHE" seq_id="2">
         <PDBx:auth_mon_id>PHE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PHE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>313</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLY" seq_id="3">
         <PDBx:auth_mon_id>GLY</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>3</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLY</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>314</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="4">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>4</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>315</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PHE" seq_id="5">
         <PDBx:auth_mon_id>PHE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>5</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PHE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>316</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="6">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>6</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>317</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
   </PDBx:pdbx_poly_seq_schemeCategory>
   <PDBx:pdbx_struct_assemblyCategory>
      <PDBx:pdbx_struct_assembly id="1">
         <PDBx:details>author_defined_assembly</PDBx:details>
         <PDBx:oligomeric_count>10</PDBx:oligomeric_count>
         <PDBx:oligomeric_details>decameric</PDBx:oligomeric_details>
      </PDBx:pdbx_struct_assembly>
   </PDBx:pdbx_struct_assemblyCategory>
   <PDBx:pdbx_struct_assembly_auth_evidenceCategory>
      <PDBx:pdbx_struct_assembly_auth_evidence assembly_id="1" id="1">
         <PDBx:experimental_support>none</PDBx:experimental_support>
      </PDBx:pdbx_struct_assembly_auth_evidence>
   </PDBx:pdbx_struct_assembly_auth_evidenceCategory>
   <PDBx:pdbx_struct_assembly_genCategory>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="1,2,3,4,5,6,7,8,9,10"></PDBx:pdbx_struct_assembly_gen>
   </PDBx:pdbx_struct_assembly_genCategory>
   <PDBx:pdbx_struct_oper_listCategory>
      <PDBx:pdbx_struct_oper_list id="1">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_555</PDBx:name>
         <PDBx:symmetry_operation>x,y,z</PDBx:symmetry_operation>
         <PDBx:type>identity operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="2">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_535</PDBx:name>
         <PDBx:symmetry_operation>x,y-2,z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>-9.6800000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="3">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_545</PDBx:name>
         <PDBx:symmetry_operation>x,y-1,z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>-4.8400000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="4">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_565</PDBx:name>
         <PDBx:symmetry_operation>x,y+1,z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>4.8400000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="5">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_575</PDBx:name>
         <PDBx:symmetry_operation>x,y+2,z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>9.6800000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="6">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_625</PDBx:name>
         <PDBx:symmetry_operation>-x+1,y-5/2,-z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>15.3300000000</PDBx:vector1>
         <PDBx:vector2>-12.1000000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="7">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_635</PDBx:name>
         <PDBx:symmetry_operation>-x+1,y-3/2,-z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>15.3300000000</PDBx:vector1>
         <PDBx:vector2>-7.2600000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="8">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_645</PDBx:name>
         <PDBx:symmetry_operation>-x+1,y-1/2,-z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>15.3300000000</PDBx:vector1>
         <PDBx:vector2>-2.4200000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="9">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_655</PDBx:name>
         <PDBx:symmetry_operation>-x+1,y+1/2,-z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>15.3300000000</PDBx:vector1>
         <PDBx:vector2>2.4200000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="10">
         <PDBx:matrix11>-1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>2_665</PDBx:name>
         <PDBx:symmetry_operation>-x+1,y+3/2,-z</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>15.3300000000</PDBx:vector1>
         <PDBx:vector2>7.2600000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
   </PDBx:pdbx_struct_oper_listCategory>
   <PDBx:refineCategory>
      <PDBx:refine entry_id="5WHP" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:B_iso_max>36.250</PDBx:B_iso_max>
         <PDBx:B_iso_mean>2.6260</PDBx:B_iso_mean>
         <PDBx:B_iso_min>2.000</PDBx:B_iso_min>
         <PDBx:aniso_B11>0.1900</PDBx:aniso_B11>
         <PDBx:aniso_B12>-0.0000</PDBx:aniso_B12>
         <PDBx:aniso_B13>-0.1700</PDBx:aniso_B13>
         <PDBx:aniso_B22>0.0700</PDBx:aniso_B22>
         <PDBx:aniso_B23>0.0000</PDBx:aniso_B23>
         <PDBx:aniso_B33>-0.2300</PDBx:aniso_B33>
         <PDBx:correlation_coeff_Fo_to_Fc>0.9860</PDBx:correlation_coeff_Fo_to_Fc>
         <PDBx:correlation_coeff_Fo_to_Fc_free>0.9830</PDBx:correlation_coeff_Fo_to_Fc_free>
         <PDBx:details>HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES      : REFINED INDIVIDUALLY</PDBx:details>
         <PDBx:ls_R_factor_R_free>0.0929</PDBx:ls_R_factor_R_free>
         <PDBx:ls_R_factor_R_work>0.0866</PDBx:ls_R_factor_R_work>
         <PDBx:ls_R_factor_obs>0.0873</PDBx:ls_R_factor_obs>
         <PDBx:ls_d_res_high>1.0000</PDBx:ls_d_res_high>
         <PDBx:ls_d_res_low>15.2200</PDBx:ls_d_res_low>
         <PDBx:ls_number_reflns_R_free>183</PDBx:ls_number_reflns_R_free>
         <PDBx:ls_number_reflns_obs>1639</PDBx:ls_number_reflns_obs>
         <PDBx:ls_percent_reflns_R_free>10.0000</PDBx:ls_percent_reflns_R_free>
         <PDBx:ls_percent_reflns_obs>87.6800</PDBx:ls_percent_reflns_obs>
         <PDBx:overall_SU_B>0.4360</PDBx:overall_SU_B>
         <PDBx:overall_SU_ML>0.0100</PDBx:overall_SU_ML>
         <PDBx:pdbx_R_Free_selection_details>RANDOM</PDBx:pdbx_R_Free_selection_details>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_ls_cross_valid_method>THROUGHOUT</PDBx:pdbx_ls_cross_valid_method>
         <PDBx:pdbx_ls_sigma_F>0.000</PDBx:pdbx_ls_sigma_F>
         <PDBx:pdbx_method_to_determine_struct>AB INITIO PHASING</PDBx:pdbx_method_to_determine_struct>
         <PDBx:pdbx_overall_ESU_R>0.0200</PDBx:pdbx_overall_ESU_R>
         <PDBx:pdbx_overall_ESU_R_Free>0.0180</PDBx:pdbx_overall_ESU_R_Free>
         <PDBx:pdbx_solvent_ion_probe_radii>0.8000</PDBx:pdbx_solvent_ion_probe_radii>
         <PDBx:pdbx_solvent_shrinkage_radii>0.8000</PDBx:pdbx_solvent_shrinkage_radii>
         <PDBx:pdbx_solvent_vdw_probe_radii>1.2000</PDBx:pdbx_solvent_vdw_probe_radii>
      </PDBx:refine>
   </PDBx:refineCategory>
   <PDBx:refine_histCategory>
      <PDBx:refine_hist cycle_id="final" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:d_res_high>1.0000</PDBx:d_res_high>
         <PDBx:d_res_low>15.2200</PDBx:d_res_low>
         <PDBx:number_atoms_solvent>3</PDBx:number_atoms_solvent>
         <PDBx:number_atoms_total>51</PDBx:number_atoms_total>
         <PDBx:pdbx_B_iso_mean_solvent>14.75</PDBx:pdbx_B_iso_mean_solvent>
         <PDBx:pdbx_number_atoms_ligand>0</PDBx:pdbx_number_atoms_ligand>
         <PDBx:pdbx_number_atoms_nucleic_acid>0</PDBx:pdbx_number_atoms_nucleic_acid>
         <PDBx:pdbx_number_atoms_protein>48</PDBx:pdbx_number_atoms_protein>
         <PDBx:pdbx_number_residues_total>6</PDBx:pdbx_number_residues_total>
      </PDBx:refine_hist>
   </PDBx:refine_histCategory>
   <PDBx:refine_ls_restrCategory>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_bond_refined_d">
         <PDBx:dev_ideal>0.019</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>49</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_bond_other_d">
         <PDBx:dev_ideal>0.001</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>39</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_angle_refined_deg">
         <PDBx:dev_ideal>1.790</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>1.874</PDBx:dev_ideal_target>
         <PDBx:number>65</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_angle_other_deg">
         <PDBx:dev_ideal>0.687</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>3.000</PDBx:dev_ideal_target>
         <PDBx:number>88</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_dihedral_angle_1_deg">
         <PDBx:dev_ideal>4.212</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>5.000</PDBx:dev_ideal_target>
         <PDBx:number>5</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_dihedral_angle_2_deg">
         <PDBx:dev_ideal>14.007</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>23.333</PDBx:dev_ideal_target>
         <PDBx:number>3</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_dihedral_angle_3_deg">
         <PDBx:dev_ideal>8.865</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>15.000</PDBx:dev_ideal_target>
         <PDBx:number>5</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_chiral_restr">
         <PDBx:dev_ideal>0.132</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.200</PDBx:dev_ideal_target>
         <PDBx:number>6</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_gen_planes_refined">
         <PDBx:dev_ideal>0.009</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>59</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_gen_planes_other">
         <PDBx:dev_ideal>0.001</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>0.020</PDBx:dev_ideal_target>
         <PDBx:number>17</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_rigid_bond_restr">
         <PDBx:dev_ideal>5.773</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>3.000</PDBx:dev_ideal_target>
         <PDBx:number>88</PDBx:number>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="r_sphericity_bonded">
         <PDBx:dev_ideal>2.030</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>5.000</PDBx:dev_ideal_target>
         <PDBx:number>90</PDBx:number>
      </PDBx:refine_ls_restr>
   </PDBx:refine_ls_restrCategory>
   <PDBx:refine_ls_shellCategory>
      <PDBx:refine_ls_shell d_res_high="1.0020" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:R_factor_R_free>0.1870</PDBx:R_factor_R_free>
         <PDBx:R_factor_R_free_error>0.0000</PDBx:R_factor_R_free_error>
         <PDBx:R_factor_R_work>0.1320</PDBx:R_factor_R_work>
         <PDBx:d_res_low>1.0280</PDBx:d_res_low>
         <PDBx:number_reflns_R_free>5</PDBx:number_reflns_R_free>
         <PDBx:number_reflns_R_work>42</PDBx:number_reflns_R_work>
         <PDBx:number_reflns_all>47</PDBx:number_reflns_all>
         <PDBx:pdbx_total_number_of_bins_used>20</PDBx:pdbx_total_number_of_bins_used>
         <PDBx:percent_reflns_obs>35.0700</PDBx:percent_reflns_obs>
      </PDBx:refine_ls_shell>
   </PDBx:refine_ls_shellCategory>
   <PDBx:reflnsCategory>
      <PDBx:reflns pdbx_ordinal="1">
         <PDBx:B_iso_Wilson_estimate>4.863</PDBx:B_iso_Wilson_estimate>
         <PDBx:d_resolution_high>1.000</PDBx:d_resolution_high>
         <PDBx:d_resolution_low>15.220</PDBx:d_resolution_low>
         <PDBx:entry_id>5WHP</PDBx:entry_id>
         <PDBx:number_obs>1823</PDBx:number_obs>
         <PDBx:observed_criterion_sigma_I>-3.000</PDBx:observed_criterion_sigma_I>
         <PDBx:pdbx_CC_half>0.993</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rmerge_I_obs>0.086</PDBx:pdbx_Rmerge_I_obs>
         <PDBx:pdbx_Rrim_I_all>0.096</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_chi_squared>0.959</PDBx:pdbx_chi_squared>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_netI_over_sigmaI>14.970</PDBx:pdbx_netI_over_sigmaI>
         <PDBx:pdbx_redundancy>4.918</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_obs>87.600</PDBx:percent_possible_obs>
      </PDBx:reflns>
   </PDBx:reflnsCategory>
   <PDBx:reflns_shellCategory>
      <PDBx:reflns_shell pdbx_ordinal="1">
         <PDBx:Rmerge_I_obs>0.104</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.000</PDBx:d_res_high>
         <PDBx:d_res_low>1.030</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>7.590</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>57</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.980</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.125</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>2.842</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>37.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="2">
         <PDBx:Rmerge_I_obs>0.091</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.030</PDBx:d_res_high>
         <PDBx:d_res_low>1.060</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>8.940</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>90</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.991</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.108</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>3.278</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>56.600</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="3">
         <PDBx:Rmerge_I_obs>0.087</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.060</PDBx:d_res_high>
         <PDBx:d_res_low>1.100</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>10.820</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>106</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.989</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.103</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>3.387</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>71.100</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="4">
         <PDBx:Rmerge_I_obs>0.104</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.100</PDBx:d_res_high>
         <PDBx:d_res_low>1.140</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>12.570</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>149</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.989</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.118</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>4.262</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>95.500</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="5">
         <PDBx:Rmerge_I_obs>0.106</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.140</PDBx:d_res_high>
         <PDBx:d_res_low>1.180</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>13.840</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>157</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.988</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.119</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>4.866</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>99.400</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="6">
         <PDBx:Rmerge_I_obs>0.097</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.180</PDBx:d_res_high>
         <PDBx:d_res_low>1.230</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>14.650</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>131</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.993</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.106</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.366</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>92.900</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="7">
         <PDBx:Rmerge_I_obs>0.094</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.230</PDBx:d_res_high>
         <PDBx:d_res_low>1.280</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>15.400</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>127</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.990</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.103</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.591</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="8">
         <PDBx:Rmerge_I_obs>0.088</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.280</PDBx:d_res_high>
         <PDBx:d_res_low>1.340</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>16.090</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>127</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.991</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.098</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.591</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="9">
         <PDBx:Rmerge_I_obs>0.086</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.340</PDBx:d_res_high>
         <PDBx:d_res_low>1.420</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>15.000</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>128</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.995</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.096</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.422</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>99.200</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="10">
         <PDBx:Rmerge_I_obs>0.087</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.420</PDBx:d_res_high>
         <PDBx:d_res_low>1.500</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>16.680</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>124</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.992</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.097</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.484</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="11">
         <PDBx:Rmerge_I_obs>0.077</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.500</PDBx:d_res_high>
         <PDBx:d_res_low>1.610</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>16.730</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>122</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.993</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.086</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.262</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="12">
         <PDBx:Rmerge_I_obs>0.088</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.610</PDBx:d_res_high>
         <PDBx:d_res_low>1.730</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>17.470</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>91</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.995</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.097</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.582</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>98.900</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="13">
         <PDBx:Rmerge_I_obs>0.085</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.730</PDBx:d_res_high>
         <PDBx:d_res_low>1.900</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>17.930</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>96</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.994</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.093</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.573</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="14">
         <PDBx:Rmerge_I_obs>0.087</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>1.900</PDBx:d_res_high>
         <PDBx:d_res_low>2.120</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>17.980</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>90</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.989</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.095</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.422</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>100.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="15">
         <PDBx:Rmerge_I_obs>0.085</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.120</PDBx:d_res_high>
         <PDBx:d_res_low>2.450</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>17.970</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>91</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.987</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.095</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>5.088</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>97.800</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="16">
         <PDBx:Rmerge_I_obs>0.072</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.450</PDBx:d_res_high>
         <PDBx:d_res_low>3.000</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>18.000</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>65</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.992</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.082</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>4.938</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>97.000</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="17">
         <PDBx:Rmerge_I_obs>0.075</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>3.000</PDBx:d_res_high>
         <PDBx:d_res_low>4.250</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>17.040</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>49</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.989</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.085</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>4.490</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>81.700</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
      <PDBx:reflns_shell pdbx_ordinal="18">
         <PDBx:Rmerge_I_obs>0.068</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>4.250</PDBx:d_res_high>
         <PDBx:d_res_low>15.220</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>14.570</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_obs>23</PDBx:number_unique_obs>
         <PDBx:pdbx_CC_half>0.989</PDBx:pdbx_CC_half>
         <PDBx:pdbx_Rrim_I_all>0.083</PDBx:pdbx_Rrim_I_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_redundancy>3.348</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_all>62.200</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
   </PDBx:reflns_shellCategory>
   <PDBx:softwareCategory>
      <PDBx:software pdbx_ordinal="1">
         <PDBx:classification>data scaling</PDBx:classification>
         <PDBx:name>XSCALE</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="2">
         <PDBx:classification>refinement</PDBx:classification>
         <PDBx:name>REFMAC</PDBx:name>
         <PDBx:version>5.7.0032</PDBx:version>
      </PDBx:software>
      <PDBx:software pdbx_ordinal="3">
         <PDBx:classification>data extraction</PDBx:classification>
         <PDBx:name>PDB_EXTRACT</PDBx:name>
         <PDBx:version>3.22</PDBx:version>
      </PDBx:software>
      <PDBx:software pdbx_ordinal="4">
         <PDBx:classification>phasing</PDBx:classification>
         <PDBx:name>SHELXD</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="5">
         <PDBx:classification>data reduction</PDBx:classification>
         <PDBx:name>XDS</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
   </PDBx:softwareCategory>
   <PDBx:structCategory>
      <PDBx:struct entry_id="5WHP">
         <PDBx:pdbx_CASP_flag>N</PDBx:pdbx_CASP_flag>
         <PDBx:pdbx_descriptor>Segment of TAR DNA-binding protein 43</PDBx:pdbx_descriptor>
         <PDBx:title>Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low complexity domain of TDP-43, residues 312-317</PDBx:title>
      </PDBx:struct>
   </PDBx:structCategory>
   <PDBx:struct_asymCategory>
      <PDBx:struct_asym id="A">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="B">
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
   </PDBx:struct_asymCategory>
   <PDBx:struct_keywordsCategory>
      <PDBx:struct_keywords entry_id="5WHP">
         <PDBx:pdbx_keywords>PROTEIN FIBRIL</PDBx:pdbx_keywords>
         <PDBx:text>Amyloid, LARKS, TDP-43, PROTEIN FIBRIL</PDBx:text>
      </PDBx:struct_keywords>
   </PDBx:struct_keywordsCategory>
   <PDBx:struct_refCategory>
      <PDBx:struct_ref id="1">
         <PDBx:db_code>TADBP_HUMAN</PDBx:db_code>
         <PDBx:db_name>UNP</PDBx:db_name>
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_align_begin>312</PDBx:pdbx_align_begin>
         <PDBx:pdbx_db_accession>Q13148</PDBx:pdbx_db_accession>
         <PDBx:pdbx_seq_one_letter_code>NFGAFS</PDBx:pdbx_seq_one_letter_code>
      </PDBx:struct_ref>
   </PDBx:struct_refCategory>
   <PDBx:struct_ref_seqCategory>
      <PDBx:struct_ref_seq align_id="1">
         <PDBx:db_align_beg>312</PDBx:db_align_beg>
         <PDBx:db_align_end>317</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>5WHP</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>312</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>317</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>Q13148</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>6</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
   </PDBx:struct_ref_seqCategory>
   <PDBx:struct_ref_seq_difCategory>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="1">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:db_mon_id>ALA</PDBx:db_mon_id>
         <PDBx:details>engineered mutation</PDBx:details>
         <PDBx:mon_id>THR</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>315</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>5WHP</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>Q13148</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:pdbx_seq_db_seq_num>315</PDBx:pdbx_seq_db_seq_num>
         <PDBx:seq_num>4</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
   </PDBx:struct_ref_seq_difCategory>
   <PDBx:symmetryCategory>
      <PDBx:symmetry entry_id="5WHP">
         <PDBx:Int_Tables_number>4</PDBx:Int_Tables_number>
         <PDBx:space_group_name_H-M>P 1 21 1</PDBx:space_group_name_H-M>
      </PDBx:symmetry>
   </PDBx:symmetryCategory>
</PDBx:datablock>
