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         <PDBx:journal_abbrev>Cell(Cambridge,Mass.)</PDBx:journal_abbrev>
         <PDBx:journal_id_ASTM>CELLB5</PDBx:journal_id_ASTM>
         <PDBx:journal_id_CSD>0998</PDBx:journal_id_CSD>
         <PDBx:journal_id_ISSN>0092-8674</PDBx:journal_id_ISSN>
         <PDBx:journal_volume>113</PDBx:journal_volume>
         <PDBx:page_first>609</PDBx:page_first>
         <PDBx:page_last>620</PDBx:page_last>
         <PDBx:pdbx_database_id_DOI>10.1016/S0092-8674(03)00364-7</PDBx:pdbx_database_id_DOI>
         <PDBx:pdbx_database_id_PubMed>12787502</PDBx:pdbx_database_id_PubMed>
         <PDBx:title>Mechanism of Ubiquitin Recognition by the CUE Domain of Vps9p</PDBx:title>
         <PDBx:year>2003</PDBx:year>
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         <PDBx:type>APS BEAMLINE 19-ID</PDBx:type>
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         <PDBx:pdbx_mutation>G440E</PDBx:pdbx_mutation>
         <PDBx:pdbx_number_of_molecules>1</PDBx:pdbx_number_of_molecules>
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         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
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         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="16">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASN" num="17">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="THR" num="18">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="19">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLN" num="20">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASN" num="21">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="MSE" num="22">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="PHE" num="23">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="PRO" num="24">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASP" num="25">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="MSE" num="26">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASP" num="27">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="PRO" num="28">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="SER" num="29">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="30">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ILE" num="31">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLU" num="32">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASP" num="33">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="VAL" num="34">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="CYS" num="35">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ILE" num="36">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ALA" num="37">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LYS" num="38">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LYS" num="39">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="SER" num="40">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ARG" num="41">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ILE" num="42">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLU" num="43">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="PRO" num="44">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="CYS" num="45">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="VAL" num="46">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ASP" num="47">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="ALA" num="48">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="49">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="50">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="SER" num="51">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="LEU" num="52">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="SER" num="53">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
      <PDBx:entity_poly_seq entity_id="1" mon_id="GLU" num="54">
         <PDBx:hetero>n</PDBx:hetero>
      </PDBx:entity_poly_seq>
   </PDBx:entity_poly_seqCategory>
   <PDBx:entity_src_genCategory>
      <PDBx:entity_src_gen entity_id="1" pdbx_src_id="1">
         <PDBx:gene_src_common_name>baker&apos;s yeast</PDBx:gene_src_common_name>
         <PDBx:gene_src_genus>Saccharomyces</PDBx:gene_src_genus>
         <PDBx:host_org_genus>Escherichia</PDBx:host_org_genus>
         <PDBx:pdbx_alt_source_flag>sample</PDBx:pdbx_alt_source_flag>
         <PDBx:pdbx_gene_src_gene>VPS9</PDBx:pdbx_gene_src_gene>
         <PDBx:pdbx_gene_src_ncbi_taxonomy_id>4932</PDBx:pdbx_gene_src_ncbi_taxonomy_id>
         <PDBx:pdbx_gene_src_scientific_name>Saccharomyces cerevisiae</PDBx:pdbx_gene_src_scientific_name>
         <PDBx:pdbx_host_org_ncbi_taxonomy_id>562</PDBx:pdbx_host_org_ncbi_taxonomy_id>
         <PDBx:pdbx_host_org_scientific_name>Escherichia coli</PDBx:pdbx_host_org_scientific_name>
         <PDBx:pdbx_host_org_strain>BL21(DE3)-Rosetta</PDBx:pdbx_host_org_strain>
         <PDBx:pdbx_host_org_vector_type>PLASMID</PDBx:pdbx_host_org_vector_type>
         <PDBx:plasmid_name>pHis-parallel2</PDBx:plasmid_name>
      </PDBx:entity_src_gen>
   </PDBx:entity_src_genCategory>
   <PDBx:entryCategory>
      <PDBx:entry id="1MN3"></PDBx:entry>
   </PDBx:entryCategory>
   <PDBx:exptlCategory>
      <PDBx:exptl entry_id="1MN3" method="X-RAY DIFFRACTION">
         <PDBx:crystals_number>1</PDBx:crystals_number>
      </PDBx:exptl>
   </PDBx:exptlCategory>
   <PDBx:exptl_crystalCategory>
      <PDBx:exptl_crystal id="1">
         <PDBx:density_Matthews>3.54</PDBx:density_Matthews>
         <PDBx:density_percent_sol>65.21</PDBx:density_percent_sol>
         <PDBx:description>The number of unique reflections observed include 
Friedel pairs</PDBx:description>
      </PDBx:exptl_crystal>
   </PDBx:exptl_crystalCategory>
   <PDBx:exptl_crystal_growCategory>
      <PDBx:exptl_crystal_grow crystal_id="1">
         <PDBx:method>VAPOR DIFFUSION, HANGING DROP</PDBx:method>
         <PDBx:pH>8.5</PDBx:pH>
         <PDBx:pdbx_details>Ammonium Sulfate, Tris buffer, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K</PDBx:pdbx_details>
         <PDBx:pdbx_pH_range xsi:nil="true" />
         <PDBx:temp>293</PDBx:temp>
      </PDBx:exptl_crystal_grow>
   </PDBx:exptl_crystal_growCategory>
   <PDBx:pdbx_audit_revision_detailsCategory>
      <PDBx:pdbx_audit_revision_details data_content_type="Structure model" ordinal="1" revision_ordinal="1">
         <PDBx:provider>repository</PDBx:provider>
         <PDBx:type>Initial release</PDBx:type>
      </PDBx:pdbx_audit_revision_details>
   </PDBx:pdbx_audit_revision_detailsCategory>
   <PDBx:pdbx_audit_revision_groupCategory>
      <PDBx:pdbx_audit_revision_group data_content_type="Structure model" ordinal="1" revision_ordinal="2">
         <PDBx:group>Version format compliance</PDBx:group>
      </PDBx:pdbx_audit_revision_group>
      <PDBx:pdbx_audit_revision_group data_content_type="Structure model" ordinal="2" revision_ordinal="3">
         <PDBx:group>Derived calculations</PDBx:group>
      </PDBx:pdbx_audit_revision_group>
      <PDBx:pdbx_audit_revision_group data_content_type="Structure model" ordinal="3" revision_ordinal="3">
         <PDBx:group>Version format compliance</PDBx:group>
      </PDBx:pdbx_audit_revision_group>
   </PDBx:pdbx_audit_revision_groupCategory>
   <PDBx:pdbx_audit_revision_historyCategory>
      <PDBx:pdbx_audit_revision_history data_content_type="Structure model" ordinal="1">
         <PDBx:major_revision>1</PDBx:major_revision>
         <PDBx:minor_revision>0</PDBx:minor_revision>
         <PDBx:revision_date>2003-06-10</PDBx:revision_date>
      </PDBx:pdbx_audit_revision_history>
      <PDBx:pdbx_audit_revision_history data_content_type="Structure model" ordinal="2">
         <PDBx:major_revision>1</PDBx:major_revision>
         <PDBx:minor_revision>1</PDBx:minor_revision>
         <PDBx:revision_date>2008-04-28</PDBx:revision_date>
      </PDBx:pdbx_audit_revision_history>
      <PDBx:pdbx_audit_revision_history data_content_type="Structure model" ordinal="3">
         <PDBx:major_revision>1</PDBx:major_revision>
         <PDBx:minor_revision>2</PDBx:minor_revision>
         <PDBx:revision_date>2011-07-13</PDBx:revision_date>
      </PDBx:pdbx_audit_revision_history>
   </PDBx:pdbx_audit_revision_historyCategory>
   <PDBx:pdbx_database_statusCategory>
      <PDBx:pdbx_database_status entry_id="1MN3">
         <PDBx:SG_entry xsi:nil="true" />
         <PDBx:deposit_site>RCSB</PDBx:deposit_site>
         <PDBx:pdb_format_compatible>Y</PDBx:pdb_format_compatible>
         <PDBx:process_site>RCSB</PDBx:process_site>
         <PDBx:recvd_initial_deposition_date>2002-09-04</PDBx:recvd_initial_deposition_date>
         <PDBx:status_code>REL</PDBx:status_code>
         <PDBx:status_code_sf>REL</PDBx:status_code_sf>
      </PDBx:pdbx_database_status>
   </PDBx:pdbx_database_statusCategory>
   <PDBx:pdbx_entity_nonpolyCategory>
      <PDBx:pdbx_entity_nonpoly entity_id="2">
         <PDBx:comp_id>HOH</PDBx:comp_id>
         <PDBx:name>water</PDBx:name>
      </PDBx:pdbx_entity_nonpoly>
   </PDBx:pdbx_entity_nonpolyCategory>
   <PDBx:pdbx_nonpoly_schemeCategory>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="1">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>1</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>1</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="2">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>2</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>2</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="3">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>3</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>3</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="4">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>4</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>4</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="5">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>5</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>5</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="6">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>6</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>6</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="7">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>8</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>8</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="8">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>9</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>9</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="9">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>10</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>10</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="10">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>11</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>11</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="11">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>12</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>12</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="12">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>13</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>13</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="13">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>14</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>14</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="14">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>15</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>15</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="15">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>16</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>16</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="16">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>17</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>17</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="17">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>18</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>18</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="18">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>19</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>19</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="19">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>20</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>20</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="20">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>21</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>21</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="21">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>22</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>22</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="22">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>23</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>23</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="23">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>24</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>24</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="24">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>25</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>25</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="25">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>26</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>26</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="26">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>27</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>27</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="27">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>28</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>28</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="28">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>29</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>29</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="29">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>30</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>30</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="30">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>31</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>31</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
      <PDBx:pdbx_nonpoly_scheme asym_id="B" ndb_seq_num="31">
         <PDBx:auth_mon_id>WAT</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>32</PDBx:auth_seq_num>
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:mon_id>HOH</PDBx:mon_id>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>HOH</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>32</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_nonpoly_scheme>
   </PDBx:pdbx_nonpoly_schemeCategory>
   <PDBx:pdbx_poly_seq_schemeCategory>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="1">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>398</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>1</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>398</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="2">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>399</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>2</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>399</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="3">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>400</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>3</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>400</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ILE" seq_id="4">
         <PDBx:auth_mon_id>ILE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>401</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>4</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ILE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>401</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="5">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>402</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>5</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>402</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="6">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>403</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>6</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>403</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ILE" seq_id="7">
         <PDBx:auth_mon_id>ILE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>404</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>7</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ILE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>404</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="8">
         <PDBx:auth_mon_id>GLU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>405</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>8</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>405</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="9">
         <PDBx:auth_mon_id>GLU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>406</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>9</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>406</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASN" seq_id="10">
         <PDBx:auth_mon_id>ASN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>407</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>10</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>407</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="11">
         <PDBx:auth_mon_id>GLU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>408</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>11</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>408</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ARG" seq_id="12">
         <PDBx:auth_mon_id>ARG</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>409</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>12</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ARG</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>409</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="13">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>410</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>13</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>410</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASP" seq_id="14">
         <PDBx:auth_mon_id>ASP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>411</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>14</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>411</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="15">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>412</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>15</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>412</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="16">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>413</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>16</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>413</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASN" seq_id="17">
         <PDBx:auth_mon_id>ASN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>414</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>17</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>414</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="THR" seq_id="18">
         <PDBx:auth_mon_id>THR</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>415</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>18</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>THR</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>415</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="19">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>416</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>19</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>416</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLN" seq_id="20">
         <PDBx:auth_mon_id>GLN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>417</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>20</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>417</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASN" seq_id="21">
         <PDBx:auth_mon_id>ASN</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>418</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>21</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASN</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>418</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="MSE" seq_id="22">
         <PDBx:auth_mon_id>MSE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>419</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>22</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>MSE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>419</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PHE" seq_id="23">
         <PDBx:auth_mon_id>PHE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>420</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>23</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PHE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>420</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PRO" seq_id="24">
         <PDBx:auth_mon_id>PRO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>421</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>24</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PRO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>421</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASP" seq_id="25">
         <PDBx:auth_mon_id>ASP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>422</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>25</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>422</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="MSE" seq_id="26">
         <PDBx:auth_mon_id>MSE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>423</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>26</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>MSE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>423</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASP" seq_id="27">
         <PDBx:auth_mon_id>ASP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>424</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>27</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>424</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PRO" seq_id="28">
         <PDBx:auth_mon_id>PRO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>425</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>28</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PRO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>425</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="29">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>426</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>29</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>426</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="30">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>427</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>30</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>427</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ILE" seq_id="31">
         <PDBx:auth_mon_id>ILE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>428</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>31</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ILE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>428</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="32">
         <PDBx:auth_mon_id>GLU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>429</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>32</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>429</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASP" seq_id="33">
         <PDBx:auth_mon_id>ASP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>430</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>33</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>430</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="34">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>431</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>34</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>431</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="CYS" seq_id="35">
         <PDBx:auth_mon_id>CYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>432</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>35</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>CYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>432</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ILE" seq_id="36">
         <PDBx:auth_mon_id>ILE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>433</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>36</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ILE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>433</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ALA" seq_id="37">
         <PDBx:auth_mon_id>ALA</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>434</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>37</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ALA</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>434</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="38">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>435</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>38</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>435</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LYS" seq_id="39">
         <PDBx:auth_mon_id>LYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>436</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>39</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>436</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="40">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>437</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>40</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>437</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ARG" seq_id="41">
         <PDBx:auth_mon_id>ARG</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>438</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>41</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ARG</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>438</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ILE" seq_id="42">
         <PDBx:auth_mon_id>ILE</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>439</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>42</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ILE</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>439</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="43">
         <PDBx:auth_mon_id>GLU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>440</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>43</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>440</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="PRO" seq_id="44">
         <PDBx:auth_mon_id>PRO</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>441</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>44</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>PRO</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>441</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="CYS" seq_id="45">
         <PDBx:auth_mon_id>CYS</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>442</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>45</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>CYS</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>442</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="VAL" seq_id="46">
         <PDBx:auth_mon_id>VAL</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>443</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>46</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>VAL</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>443</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ASP" seq_id="47">
         <PDBx:auth_mon_id>ASP</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>444</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>47</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ASP</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>444</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="ALA" seq_id="48">
         <PDBx:auth_mon_id>ALA</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>445</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>48</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>ALA</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>445</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="49">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>446</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>49</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>446</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="50">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>447</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>50</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>447</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="51">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>448</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>51</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>448</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="LEU" seq_id="52">
         <PDBx:auth_mon_id>LEU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>449</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>52</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>LEU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>449</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="SER" seq_id="53">
         <PDBx:auth_mon_id>SER</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>450</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>53</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>SER</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>450</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
      <PDBx:pdbx_poly_seq_scheme asym_id="A" entity_id="1" mon_id="GLU" seq_id="54">
         <PDBx:auth_mon_id>GLU</PDBx:auth_mon_id>
         <PDBx:auth_seq_num>451</PDBx:auth_seq_num>
         <PDBx:hetero>n</PDBx:hetero>
         <PDBx:ndb_seq_num>54</PDBx:ndb_seq_num>
         <PDBx:pdb_ins_code xsi:nil="true" />
         <PDBx:pdb_mon_id>GLU</PDBx:pdb_mon_id>
         <PDBx:pdb_seq_num>451</PDBx:pdb_seq_num>
         <PDBx:pdb_strand_id>A</PDBx:pdb_strand_id>
      </PDBx:pdbx_poly_seq_scheme>
   </PDBx:pdbx_poly_seq_schemeCategory>
   <PDBx:pdbx_struct_assemblyCategory>
      <PDBx:pdbx_struct_assembly id="1">
         <PDBx:details>author_defined_assembly</PDBx:details>
         <PDBx:oligomeric_count>1</PDBx:oligomeric_count>
         <PDBx:oligomeric_details>monomeric</PDBx:oligomeric_details>
      </PDBx:pdbx_struct_assembly>
      <PDBx:pdbx_struct_assembly id="2">
         <PDBx:details>software_defined_assembly</PDBx:details>
         <PDBx:method_details>PISA,PQS</PDBx:method_details>
         <PDBx:oligomeric_count>2</PDBx:oligomeric_count>
         <PDBx:oligomeric_details>dimeric</PDBx:oligomeric_details>
      </PDBx:pdbx_struct_assembly>
   </PDBx:pdbx_struct_assemblyCategory>
   <PDBx:pdbx_struct_assembly_genCategory>
      <PDBx:pdbx_struct_assembly_gen assembly_id="1" asym_id_list="A,B" oper_expression="1"></PDBx:pdbx_struct_assembly_gen>
      <PDBx:pdbx_struct_assembly_gen assembly_id="2" asym_id_list="A,B" oper_expression="1,2"></PDBx:pdbx_struct_assembly_gen>
   </PDBx:pdbx_struct_assembly_genCategory>
   <PDBx:pdbx_struct_assembly_propCategory>
      <PDBx:pdbx_struct_assembly_prop biol_id="2" type="ABSA (A^2)">
         <PDBx:value>1740</PDBx:value>
      </PDBx:pdbx_struct_assembly_prop>
      <PDBx:pdbx_struct_assembly_prop biol_id="2" type="MORE">
         <PDBx:value>-22</PDBx:value>
      </PDBx:pdbx_struct_assembly_prop>
      <PDBx:pdbx_struct_assembly_prop biol_id="2" type="SSA (A^2)">
         <PDBx:value>7490</PDBx:value>
      </PDBx:pdbx_struct_assembly_prop>
   </PDBx:pdbx_struct_assembly_propCategory>
   <PDBx:pdbx_struct_mod_residueCategory>
      <PDBx:pdbx_struct_mod_residue id="1">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>MSE</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>419</PDBx:auth_seq_id>
         <PDBx:details>SELENOMETHIONINE</PDBx:details>
         <PDBx:label_asym_id>A</PDBx:label_asym_id>
         <PDBx:label_comp_id>MSE</PDBx:label_comp_id>
         <PDBx:label_seq_id>22</PDBx:label_seq_id>
         <PDBx:parent_comp_id>MET</PDBx:parent_comp_id>
      </PDBx:pdbx_struct_mod_residue>
      <PDBx:pdbx_struct_mod_residue id="2">
         <PDBx:auth_asym_id>A</PDBx:auth_asym_id>
         <PDBx:auth_comp_id>MSE</PDBx:auth_comp_id>
         <PDBx:auth_seq_id>423</PDBx:auth_seq_id>
         <PDBx:details>SELENOMETHIONINE</PDBx:details>
         <PDBx:label_asym_id>A</PDBx:label_asym_id>
         <PDBx:label_comp_id>MSE</PDBx:label_comp_id>
         <PDBx:label_seq_id>26</PDBx:label_seq_id>
         <PDBx:parent_comp_id>MET</PDBx:parent_comp_id>
      </PDBx:pdbx_struct_mod_residue>
   </PDBx:pdbx_struct_mod_residueCategory>
   <PDBx:pdbx_struct_oper_listCategory>
      <PDBx:pdbx_struct_oper_list id="1">
         <PDBx:matrix11>1.0000000000</PDBx:matrix11>
         <PDBx:matrix12>0.0000000000</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.0000000000</PDBx:matrix21>
         <PDBx:matrix22>1.0000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>1.0000000000</PDBx:matrix33>
         <PDBx:name>1_555</PDBx:name>
         <PDBx:symmetry_operation>x,y,z</PDBx:symmetry_operation>
         <PDBx:type>identity operation</PDBx:type>
         <PDBx:vector1>0.0000000000</PDBx:vector1>
         <PDBx:vector2>0.0000000000</PDBx:vector2>
         <PDBx:vector3>0.0000000000</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
      <PDBx:pdbx_struct_oper_list id="2">
         <PDBx:matrix11>0.5000000000</PDBx:matrix11>
         <PDBx:matrix12>0.8660254038</PDBx:matrix12>
         <PDBx:matrix13>0.0000000000</PDBx:matrix13>
         <PDBx:matrix21>0.8660254038</PDBx:matrix21>
         <PDBx:matrix22>-0.5000000000</PDBx:matrix22>
         <PDBx:matrix23>0.0000000000</PDBx:matrix23>
         <PDBx:matrix31>0.0000000000</PDBx:matrix31>
         <PDBx:matrix32>0.0000000000</PDBx:matrix32>
         <PDBx:matrix33>-1.0000000000</PDBx:matrix33>
         <PDBx:name>12_565</PDBx:name>
         <PDBx:symmetry_operation>x,x-y+1,-z+5/6</PDBx:symmetry_operation>
         <PDBx:type>crystal symmetry operation</PDBx:type>
         <PDBx:vector1>-35.2435000000</PDBx:vector1>
         <PDBx:vector2>61.0435326366</PDBx:vector2>
         <PDBx:vector3>51.1533333333</PDBx:vector3>
      </PDBx:pdbx_struct_oper_list>
   </PDBx:pdbx_struct_oper_listCategory>
   <PDBx:pdbx_validate_symm_contactCategory>
      <PDBx:pdbx_validate_symm_contact id="1">
         <PDBx:PDB_model_num>1</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>O</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>O</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>HOH</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HOH</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>19</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>19</PDBx:auth_seq_id_2>
         <PDBx:dist>1.21</PDBx:dist>
         <PDBx:site_symmetry_1>1_555</PDBx:site_symmetry_1>
         <PDBx:site_symmetry_2>9_555</PDBx:site_symmetry_2>
      </PDBx:pdbx_validate_symm_contact>
      <PDBx:pdbx_validate_symm_contact id="2">
         <PDBx:PDB_model_num>1</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>O</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>O</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>HOH</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HOH</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>29</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>29</PDBx:auth_seq_id_2>
         <PDBx:dist>1.40</PDBx:dist>
         <PDBx:site_symmetry_1>1_555</PDBx:site_symmetry_1>
         <PDBx:site_symmetry_2>10_666</PDBx:site_symmetry_2>
      </PDBx:pdbx_validate_symm_contact>
      <PDBx:pdbx_validate_symm_contact id="3">
         <PDBx:PDB_model_num>1</PDBx:PDB_model_num>
         <PDBx:auth_asym_id_1>A</PDBx:auth_asym_id_1>
         <PDBx:auth_asym_id_2>A</PDBx:auth_asym_id_2>
         <PDBx:auth_atom_id_1>O</PDBx:auth_atom_id_1>
         <PDBx:auth_atom_id_2>O</PDBx:auth_atom_id_2>
         <PDBx:auth_comp_id_1>HOH</PDBx:auth_comp_id_1>
         <PDBx:auth_comp_id_2>HOH</PDBx:auth_comp_id_2>
         <PDBx:auth_seq_id_1>10</PDBx:auth_seq_id_1>
         <PDBx:auth_seq_id_2>10</PDBx:auth_seq_id_2>
         <PDBx:dist>1.66</PDBx:dist>
         <PDBx:site_symmetry_1>1_555</PDBx:site_symmetry_1>
         <PDBx:site_symmetry_2>12_565</PDBx:site_symmetry_2>
      </PDBx:pdbx_validate_symm_contact>
   </PDBx:pdbx_validate_symm_contactCategory>
   <PDBx:pdbx_xplor_fileCategory>
      <PDBx:pdbx_xplor_file pdbx_refine_id="X-RAY DIFFRACTION" serial_no="1">
         <PDBx:param_file>PROTEIN_REP.PARAM</PDBx:param_file>
         <PDBx:topol_file>PROTEIN.TOP</PDBx:topol_file>
      </PDBx:pdbx_xplor_file>
      <PDBx:pdbx_xplor_file pdbx_refine_id="X-RAY DIFFRACTION" serial_no="2">
         <PDBx:param_file>WATER_REP.PARAM</PDBx:param_file>
         <PDBx:topol_file>WATER.TOP</PDBx:topol_file>
      </PDBx:pdbx_xplor_file>
   </PDBx:pdbx_xplor_fileCategory>
   <PDBx:refineCategory>
      <PDBx:refine entry_id="1MN3" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:B_iso_mean>42.2</PDBx:B_iso_mean>
         <PDBx:aniso_B11>0.34</PDBx:aniso_B11>
         <PDBx:aniso_B12>5.75</PDBx:aniso_B12>
         <PDBx:aniso_B13>0.00</PDBx:aniso_B13>
         <PDBx:aniso_B22>0.34</PDBx:aniso_B22>
         <PDBx:aniso_B23>0.00</PDBx:aniso_B23>
         <PDBx:aniso_B33>-0.68</PDBx:aniso_B33>
         <PDBx:ls_R_factor_R_free>0.266</PDBx:ls_R_factor_R_free>
         <PDBx:ls_R_factor_R_free_error>0.010</PDBx:ls_R_factor_R_free_error>
         <PDBx:ls_R_factor_R_work>0.244</PDBx:ls_R_factor_R_work>
         <PDBx:ls_d_res_high>2.3</PDBx:ls_d_res_high>
         <PDBx:ls_d_res_low>43.29</PDBx:ls_d_res_low>
         <PDBx:ls_number_reflns_R_free>763</PDBx:ls_number_reflns_R_free>
         <PDBx:ls_number_reflns_all>7562</PDBx:ls_number_reflns_all>
         <PDBx:ls_number_reflns_obs>7325</PDBx:ls_number_reflns_obs>
         <PDBx:ls_percent_reflns_R_free>10.4</PDBx:ls_percent_reflns_R_free>
         <PDBx:ls_percent_reflns_obs>96.6</PDBx:ls_percent_reflns_obs>
         <PDBx:pdbx_R_Free_selection_details>RANDOM</PDBx:pdbx_R_Free_selection_details>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_isotropic_thermal_model>RESTRAINED</PDBx:pdbx_isotropic_thermal_model>
         <PDBx:pdbx_ls_cross_valid_method>THROUGHOUT</PDBx:pdbx_ls_cross_valid_method>
         <PDBx:pdbx_ls_sigma_F>0.0</PDBx:pdbx_ls_sigma_F>
         <PDBx:pdbx_method_to_determine_struct>MAD</PDBx:pdbx_method_to_determine_struct>
         <PDBx:pdbx_stereochemistry_target_values>Engh &amp; Huber</PDBx:pdbx_stereochemistry_target_values>
         <PDBx:solvent_model_details>FLAT MODEL</PDBx:solvent_model_details>
         <PDBx:solvent_model_param_bsol>39.9679</PDBx:solvent_model_param_bsol>
         <PDBx:solvent_model_param_ksol>0.3658</PDBx:solvent_model_param_ksol>
      </PDBx:refine>
   </PDBx:refineCategory>
   <PDBx:refine_analyzeCategory>
      <PDBx:refine_analyze entry_id="1MN3" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:Luzzati_coordinate_error_free>0.39</PDBx:Luzzati_coordinate_error_free>
         <PDBx:Luzzati_coordinate_error_obs>0.31</PDBx:Luzzati_coordinate_error_obs>
         <PDBx:Luzzati_d_res_low_obs>5.00</PDBx:Luzzati_d_res_low_obs>
         <PDBx:Luzzati_sigma_a_free>0.38</PDBx:Luzzati_sigma_a_free>
      </PDBx:refine_analyze>
   </PDBx:refine_analyzeCategory>
   <PDBx:refine_histCategory>
      <PDBx:refine_hist cycle_id="LAST" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:d_res_high>2.3</PDBx:d_res_high>
         <PDBx:d_res_low>43.29</PDBx:d_res_low>
         <PDBx:number_atoms_solvent>31</PDBx:number_atoms_solvent>
         <PDBx:number_atoms_total>456</PDBx:number_atoms_total>
         <PDBx:pdbx_number_atoms_ligand>0</PDBx:pdbx_number_atoms_ligand>
         <PDBx:pdbx_number_atoms_nucleic_acid>0</PDBx:pdbx_number_atoms_nucleic_acid>
         <PDBx:pdbx_number_atoms_protein>425</PDBx:pdbx_number_atoms_protein>
      </PDBx:refine_hist>
   </PDBx:refine_histCategory>
   <PDBx:refine_ls_restrCategory>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="c_bond_d">
         <PDBx:dev_ideal>0.006</PDBx:dev_ideal>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="c_angle_deg">
         <PDBx:dev_ideal>1.1</PDBx:dev_ideal>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="c_dihedral_angle_d">
         <PDBx:dev_ideal>18.4</PDBx:dev_ideal>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="c_improper_angle_d">
         <PDBx:dev_ideal>0.86</PDBx:dev_ideal>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="c_mcbond_it">
         <PDBx:dev_ideal>1.74</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>1.50</PDBx:dev_ideal_target>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="c_mcangle_it">
         <PDBx:dev_ideal>2.89</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>2.00</PDBx:dev_ideal_target>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="c_scbond_it">
         <PDBx:dev_ideal>3.25</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>2.00</PDBx:dev_ideal_target>
      </PDBx:refine_ls_restr>
      <PDBx:refine_ls_restr pdbx_refine_id="X-RAY DIFFRACTION" type="c_scangle_it">
         <PDBx:dev_ideal>4.36</PDBx:dev_ideal>
         <PDBx:dev_ideal_target>2.50</PDBx:dev_ideal_target>
      </PDBx:refine_ls_restr>
   </PDBx:refine_ls_restrCategory>
   <PDBx:refine_ls_shellCategory>
      <PDBx:refine_ls_shell d_res_high="2.3" pdbx_refine_id="X-RAY DIFFRACTION">
         <PDBx:R_factor_R_free>0.363</PDBx:R_factor_R_free>
         <PDBx:R_factor_R_free_error>0.038</PDBx:R_factor_R_free_error>
         <PDBx:R_factor_R_work>0.302</PDBx:R_factor_R_work>
         <PDBx:d_res_low>2.44</PDBx:d_res_low>
         <PDBx:number_reflns_R_free>91</PDBx:number_reflns_R_free>
         <PDBx:number_reflns_R_work>1043</PDBx:number_reflns_R_work>
         <PDBx:number_reflns_obs>1043</PDBx:number_reflns_obs>
         <PDBx:pdbx_total_number_of_bins_used>6</PDBx:pdbx_total_number_of_bins_used>
         <PDBx:percent_reflns_R_free>8.0</PDBx:percent_reflns_R_free>
         <PDBx:percent_reflns_obs>88.6</PDBx:percent_reflns_obs>
      </PDBx:refine_ls_shell>
   </PDBx:refine_ls_shellCategory>
   <PDBx:reflnsCategory>
      <PDBx:reflns pdbx_ordinal="1">
         <PDBx:d_resolution_high>2.3</PDBx:d_resolution_high>
         <PDBx:d_resolution_low>50.0</PDBx:d_resolution_low>
         <PDBx:entry_id>1MN3</PDBx:entry_id>
         <PDBx:number_all>7562</PDBx:number_all>
         <PDBx:number_obs>7325</PDBx:number_obs>
         <PDBx:observed_criterion_sigma_I>-3.0</PDBx:observed_criterion_sigma_I>
         <PDBx:pdbx_Rmerge_I_obs>0.079</PDBx:pdbx_Rmerge_I_obs>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:pdbx_netI_over_sigmaI>39.5</PDBx:pdbx_netI_over_sigmaI>
         <PDBx:pdbx_redundancy>24.5</PDBx:pdbx_redundancy>
         <PDBx:percent_possible_obs>99.8</PDBx:percent_possible_obs>
      </PDBx:reflns>
   </PDBx:reflnsCategory>
   <PDBx:reflns_shellCategory>
      <PDBx:reflns_shell pdbx_ordinal="1">
         <PDBx:Rmerge_I_obs>0.418</PDBx:Rmerge_I_obs>
         <PDBx:d_res_high>2.3</PDBx:d_res_high>
         <PDBx:d_res_low>2.38</PDBx:d_res_low>
         <PDBx:meanI_over_sigI_obs>6.8</PDBx:meanI_over_sigI_obs>
         <PDBx:number_unique_all>415</PDBx:number_unique_all>
         <PDBx:pdbx_diffrn_id>1</PDBx:pdbx_diffrn_id>
         <PDBx:percent_possible_all>100.0</PDBx:percent_possible_all>
      </PDBx:reflns_shell>
   </PDBx:reflns_shellCategory>
   <PDBx:softwareCategory>
      <PDBx:software pdbx_ordinal="1">
         <PDBx:classification>data reduction</PDBx:classification>
         <PDBx:name>DENZO</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="2">
         <PDBx:classification>data scaling</PDBx:classification>
         <PDBx:name>SCALEPACK</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="3">
         <PDBx:classification>phasing</PDBx:classification>
         <PDBx:name>SOLVE</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="4">
         <PDBx:classification>model building</PDBx:classification>
         <PDBx:name>RESOLVE</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
      <PDBx:software pdbx_ordinal="5">
         <PDBx:classification>refinement</PDBx:classification>
         <PDBx:name>CNS</PDBx:name>
         <PDBx:version>1.1</PDBx:version>
      </PDBx:software>
      <PDBx:software pdbx_ordinal="6">
         <PDBx:classification>phasing</PDBx:classification>
         <PDBx:name>RESOLVE</PDBx:name>
         <PDBx:version xsi:nil="true" />
      </PDBx:software>
   </PDBx:softwareCategory>
   <PDBx:structCategory>
      <PDBx:struct entry_id="1MN3">
         <PDBx:pdbx_descriptor>Vacuolar protein sorting-associated protein VPS9</PDBx:pdbx_descriptor>
         <PDBx:title>Cue domain of yeast Vps9p</PDBx:title>
      </PDBx:struct>
   </PDBx:structCategory>
   <PDBx:struct_asymCategory>
      <PDBx:struct_asym id="A">
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
      <PDBx:struct_asym id="B">
         <PDBx:entity_id>2</PDBx:entity_id>
         <PDBx:pdbx_blank_PDB_chainid_flag>N</PDBx:pdbx_blank_PDB_chainid_flag>
         <PDBx:pdbx_modified>N</PDBx:pdbx_modified>
      </PDBx:struct_asym>
   </PDBx:struct_asymCategory>
   <PDBx:struct_biolCategory>
      <PDBx:struct_biol id="1">
      </PDBx:struct_biol>
   </PDBx:struct_biolCategory>
   <PDBx:struct_confCategory>
      <PDBx:struct_conf id="HELX_P1">
         <PDBx:beg_auth_asym_id>A</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>SER</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>398</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>A</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>SER</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>1</PDBx:beg_label_seq_id>
         <PDBx:conf_type_id>HELX_P</PDBx:conf_type_id>
         <PDBx:end_auth_asym_id>A</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>PHE</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>420</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>A</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>PHE</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>23</PDBx:end_label_seq_id>
         <PDBx:pdbx_PDB_helix_class>1</PDBx:pdbx_PDB_helix_class>
         <PDBx:pdbx_PDB_helix_id>1</PDBx:pdbx_PDB_helix_id>
         <PDBx:pdbx_PDB_helix_length>23</PDBx:pdbx_PDB_helix_length>
      </PDBx:struct_conf>
      <PDBx:struct_conf id="HELX_P2">
         <PDBx:beg_auth_asym_id>A</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>ASP</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>424</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>A</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>ASP</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>27</PDBx:beg_label_seq_id>
         <PDBx:conf_type_id>HELX_P</PDBx:conf_type_id>
         <PDBx:end_auth_asym_id>A</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>ILE</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>433</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>A</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>ILE</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>36</PDBx:end_label_seq_id>
         <PDBx:pdbx_PDB_helix_class>1</PDBx:pdbx_PDB_helix_class>
         <PDBx:pdbx_PDB_helix_id>2</PDBx:pdbx_PDB_helix_id>
         <PDBx:pdbx_PDB_helix_length>10</PDBx:pdbx_PDB_helix_length>
      </PDBx:struct_conf>
      <PDBx:struct_conf id="HELX_P3">
         <PDBx:beg_auth_asym_id>A</PDBx:beg_auth_asym_id>
         <PDBx:beg_auth_comp_id>ARG</PDBx:beg_auth_comp_id>
         <PDBx:beg_auth_seq_id>438</PDBx:beg_auth_seq_id>
         <PDBx:beg_label_asym_id>A</PDBx:beg_label_asym_id>
         <PDBx:beg_label_comp_id>ARG</PDBx:beg_label_comp_id>
         <PDBx:beg_label_seq_id>41</PDBx:beg_label_seq_id>
         <PDBx:conf_type_id>HELX_P</PDBx:conf_type_id>
         <PDBx:end_auth_asym_id>A</PDBx:end_auth_asym_id>
         <PDBx:end_auth_comp_id>GLU</PDBx:end_auth_comp_id>
         <PDBx:end_auth_seq_id>451</PDBx:end_auth_seq_id>
         <PDBx:end_label_asym_id>A</PDBx:end_label_asym_id>
         <PDBx:end_label_comp_id>GLU</PDBx:end_label_comp_id>
         <PDBx:end_label_seq_id>54</PDBx:end_label_seq_id>
         <PDBx:pdbx_PDB_helix_class>1</PDBx:pdbx_PDB_helix_class>
         <PDBx:pdbx_PDB_helix_id>3</PDBx:pdbx_PDB_helix_id>
         <PDBx:pdbx_PDB_helix_length>14</PDBx:pdbx_PDB_helix_length>
      </PDBx:struct_conf>
   </PDBx:struct_confCategory>
   <PDBx:struct_conf_typeCategory>
      <PDBx:struct_conf_type id="HELX_P">
      </PDBx:struct_conf_type>
   </PDBx:struct_conf_typeCategory>
   <PDBx:struct_connCategory>
      <PDBx:struct_conn id="disulf1">
         <PDBx:conn_type_id>disulf</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>2.706</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>A</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>CYS</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>432</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>A</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>SG</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>CYS</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>35</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>A</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>CYS</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>442</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>A</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>SG</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>CYS</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>45</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>12_565</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
      <PDBx:struct_conn id="covale1">
         <PDBx:conn_type_id>covale</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>1.330</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>A</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>ASN</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>418</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>A</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>C</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>ASN</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>21</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>A</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>MSE</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>419</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>A</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>N</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>MSE</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>22</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>1_555</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
      <PDBx:struct_conn id="covale2">
         <PDBx:conn_type_id>covale</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>1.334</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>A</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>MSE</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>419</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>A</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>C</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>MSE</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>22</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>A</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>PHE</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>420</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>A</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>N</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>PHE</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>23</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>1_555</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
      <PDBx:struct_conn id="covale3">
         <PDBx:conn_type_id>covale</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>1.327</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>A</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>ASP</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>422</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>A</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>C</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>ASP</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>25</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>A</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>MSE</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>423</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>A</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>N</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>MSE</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>26</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>1_555</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
      <PDBx:struct_conn id="covale4">
         <PDBx:conn_type_id>covale</PDBx:conn_type_id>
         <PDBx:pdbx_dist_value>1.326</PDBx:pdbx_dist_value>
         <PDBx:ptnr1_auth_asym_id>A</PDBx:ptnr1_auth_asym_id>
         <PDBx:ptnr1_auth_comp_id>MSE</PDBx:ptnr1_auth_comp_id>
         <PDBx:ptnr1_auth_seq_id>423</PDBx:ptnr1_auth_seq_id>
         <PDBx:ptnr1_label_asym_id>A</PDBx:ptnr1_label_asym_id>
         <PDBx:ptnr1_label_atom_id>C</PDBx:ptnr1_label_atom_id>
         <PDBx:ptnr1_label_comp_id>MSE</PDBx:ptnr1_label_comp_id>
         <PDBx:ptnr1_label_seq_id>26</PDBx:ptnr1_label_seq_id>
         <PDBx:ptnr1_symmetry>1_555</PDBx:ptnr1_symmetry>
         <PDBx:ptnr2_auth_asym_id>A</PDBx:ptnr2_auth_asym_id>
         <PDBx:ptnr2_auth_comp_id>ASP</PDBx:ptnr2_auth_comp_id>
         <PDBx:ptnr2_auth_seq_id>424</PDBx:ptnr2_auth_seq_id>
         <PDBx:ptnr2_label_asym_id>A</PDBx:ptnr2_label_asym_id>
         <PDBx:ptnr2_label_atom_id>N</PDBx:ptnr2_label_atom_id>
         <PDBx:ptnr2_label_comp_id>ASP</PDBx:ptnr2_label_comp_id>
         <PDBx:ptnr2_label_seq_id>27</PDBx:ptnr2_label_seq_id>
         <PDBx:ptnr2_symmetry>1_555</PDBx:ptnr2_symmetry>
      </PDBx:struct_conn>
   </PDBx:struct_connCategory>
   <PDBx:struct_conn_typeCategory>
      <PDBx:struct_conn_type id="disulf">
      </PDBx:struct_conn_type>
      <PDBx:struct_conn_type id="covale">
      </PDBx:struct_conn_type>
   </PDBx:struct_conn_typeCategory>
   <PDBx:struct_keywordsCategory>
      <PDBx:struct_keywords entry_id="1MN3">
         <PDBx:pdbx_keywords>PROTEIN TRANSPORT</PDBx:pdbx_keywords>
         <PDBx:text>Ubiquitin, PROTEIN TRANSPORT</PDBx:text>
      </PDBx:struct_keywords>
   </PDBx:struct_keywordsCategory>
   <PDBx:struct_refCategory>
      <PDBx:struct_ref id="1">
         <PDBx:db_code>VPS9_YEAST</PDBx:db_code>
         <PDBx:db_name>UNP</PDBx:db_name>
         <PDBx:entity_id>1</PDBx:entity_id>
         <PDBx:pdbx_align_begin>398</PDBx:pdbx_align_begin>
         <PDBx:pdbx_db_accession>P54787</PDBx:pdbx_db_accession>
         <PDBx:pdbx_seq_one_letter_code>SSLIKKIEENERKDTLNTLQNMFPDMDPSLIEDVCIAKKSRIGPCVDALLSLSE</PDBx:pdbx_seq_one_letter_code>
      </PDBx:struct_ref>
   </PDBx:struct_refCategory>
   <PDBx:struct_ref_seqCategory>
      <PDBx:struct_ref_seq align_id="1">
         <PDBx:db_align_beg>398</PDBx:db_align_beg>
         <PDBx:db_align_end>451</PDBx:db_align_end>
         <PDBx:pdbx_PDB_id_code>1MN3</PDBx:pdbx_PDB_id_code>
         <PDBx:pdbx_auth_seq_align_beg>398</PDBx:pdbx_auth_seq_align_beg>
         <PDBx:pdbx_auth_seq_align_end>451</PDBx:pdbx_auth_seq_align_end>
         <PDBx:pdbx_db_accession>P54787</PDBx:pdbx_db_accession>
         <PDBx:pdbx_strand_id>A</PDBx:pdbx_strand_id>
         <PDBx:ref_id>1</PDBx:ref_id>
         <PDBx:seq_align_beg>1</PDBx:seq_align_beg>
         <PDBx:seq_align_end>54</PDBx:seq_align_end>
      </PDBx:struct_ref_seq>
   </PDBx:struct_ref_seqCategory>
   <PDBx:struct_ref_seq_difCategory>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="1">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:db_mon_id>MET</PDBx:db_mon_id>
         <PDBx:details>MODIFIED RESIDUE</PDBx:details>
         <PDBx:mon_id>MSE</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>419</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>1MN3</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P54787</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:pdbx_seq_db_seq_num>419</PDBx:pdbx_seq_db_seq_num>
         <PDBx:seq_num>22</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="2">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:db_mon_id>MET</PDBx:db_mon_id>
         <PDBx:details>MODIFIED RESIDUE</PDBx:details>
         <PDBx:mon_id>MSE</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>423</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>1MN3</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P54787</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:pdbx_seq_db_seq_num>423</PDBx:pdbx_seq_db_seq_num>
         <PDBx:seq_num>26</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
      <PDBx:struct_ref_seq_dif pdbx_ordinal="3">
         <PDBx:align_id>1</PDBx:align_id>
         <PDBx:db_mon_id>GLY</PDBx:db_mon_id>
         <PDBx:details>ENGINEERED</PDBx:details>
         <PDBx:mon_id>GLU</PDBx:mon_id>
         <PDBx:pdbx_auth_seq_num>440</PDBx:pdbx_auth_seq_num>
         <PDBx:pdbx_pdb_id_code>1MN3</PDBx:pdbx_pdb_id_code>
         <PDBx:pdbx_pdb_strand_id>A</PDBx:pdbx_pdb_strand_id>
         <PDBx:pdbx_seq_db_accession_code>P54787</PDBx:pdbx_seq_db_accession_code>
         <PDBx:pdbx_seq_db_name>UNP</PDBx:pdbx_seq_db_name>
         <PDBx:pdbx_seq_db_seq_num>440</PDBx:pdbx_seq_db_seq_num>
         <PDBx:seq_num>43</PDBx:seq_num>
      </PDBx:struct_ref_seq_dif>
   </PDBx:struct_ref_seq_difCategory>
   <PDBx:symmetryCategory>
      <PDBx:symmetry entry_id="1MN3">
         <PDBx:Int_Tables_number>179</PDBx:Int_Tables_number>
         <PDBx:space_group_name_H-M>P 65 2 2</PDBx:space_group_name_H-M>
      </PDBx:symmetry>
   </PDBx:symmetryCategory>
</PDBx:datablock>
