#BioGRID Chemical Interaction ID	BioGRID Gene ID	Entrez Gene ID	Systematic Name	Official Symbol	Synonyms	Organism ID	Organism	Action	Interaction Type	Author	Pubmed ID	BioGRID Publication ID	BioGRID Chemical ID	Chemical Name	Chemical Synonyms	Chemical Brands	Chemical Source	Chemical Source ID	Molecular Formula	Chemical Type	ATC Codes	CAS Number	Curated By	Method	Method Description	Related BioGRID Gene ID	Related Entrez Gene ID	Related Systematic Name	Related Official Symbol	Related Synonyms	Related Organism ID	Related Organism	Related Type	Notes	InChIKey
15	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Viloria-Petit A (2001)	11431346	171748	2	Cetuximab	Immunoglobulin G 1 (human-mouse monoclonal C 225 gamma 1 - chain anti-human epidermal growt factor receptor), disulfide wit human-mouse monoclonal C 225 kappa - chain, dimer|Ctuximab|Cetuximab|Cetuximabum	erbitux	DRUGBANK	DB00002	C6484H10042N1732O2023S36	biologic	L01XC06	205923-56-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
16	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	2	Cetuximab	Immunoglobulin G 1 (human-mouse monoclonal C 225 gamma 1 - chain anti-human epidermal growt factor receptor), disulfide wit human-mouse monoclonal C 225 kappa - chain, dimer|Ctuximab|Cetuximab|Cetuximabum	erbitux	DRUGBANK	DB00002	C6484H10042N1732O2023S36	biologic	L01XC06	205923-56-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
17	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Hosokawa N (1999)	10480573	171746	2	Cetuximab	Immunoglobulin G 1 (human-mouse monoclonal C 225 gamma 1 - chain anti-human epidermal growt factor receptor), disulfide wit human-mouse monoclonal C 225 kappa - chain, dimer|Ctuximab|Cetuximab|Cetuximabum	erbitux	DRUGBANK	DB00002	C6484H10042N1732O2023S36	biologic	L01XC06	205923-56-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
18	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Wakita H (1999)	10601294	171747	2	Cetuximab	Immunoglobulin G 1 (human-mouse monoclonal C 225 gamma 1 - chain anti-human epidermal growt factor receptor), disulfide wit human-mouse monoclonal C 225 kappa - chain, dimer|Ctuximab|Cetuximab|Cetuximabum	erbitux	DRUGBANK	DB00002	C6484H10042N1732O2023S36	biologic	L01XC06	205923-56-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
19	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Suwa T (2000)	10628369	171745	2	Cetuximab	Immunoglobulin G 1 (human-mouse monoclonal C 225 gamma 1 - chain anti-human epidermal growt factor receptor), disulfide wit human-mouse monoclonal C 225 kappa - chain, dimer|Ctuximab|Cetuximab|Cetuximabum	erbitux	DRUGBANK	DB00002	C6484H10042N1732O2023S36	biologic	L01XC06	205923-56-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
20	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Burke P (2001)	11408594	141935	2	Cetuximab	Immunoglobulin G 1 (human-mouse monoclonal C 225 gamma 1 - chain anti-human epidermal growt factor receptor), disulfide wit human-mouse monoclonal C 225 kappa - chain, dimer|Ctuximab|Cetuximab|Cetuximabum	erbitux	DRUGBANK	DB00002	C6484H10042N1732O2023S36	biologic	L01XC06	205923-56-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
109	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Melandri G (2009)	19436656	171787	9	Alteplase	t-plasminogen activator|t-PA|tPA|Tissue-type plasminogen activator precursor	activase rt-pa|lysatec rt - pa	DRUGBANK	DB00009	C2569H3928N746O781S40	biologic	B01AD02|S01XA13	105857-23-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
110	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Longstaff C (2008)	18673235	171788	9	Alteplase	t-plasminogen activator|t-PA|tPA|Tissue-type plasminogen activator precursor	activase rt-pa|lysatec rt - pa	DRUGBANK	DB00009	C2569H3928N746O781S40	biologic	B01AD02|S01XA13	105857-23-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
111	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Hilleman DE (2007)	17963464	171789	9	Alteplase	t-plasminogen activator|t-PA|tPA|Tissue-type plasminogen activator precursor	activase rt-pa|lysatec rt - pa	DRUGBANK	DB00009	C2569H3928N746O781S40	biologic	B01AD02|S01XA13	105857-23-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
183	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Melandri G (2009)	19436656	171787	15	Reteplase	t-plasminogen activator|tPA|Tissue-type plasminogen activator precursor|t- PA	retavase	DRUGBANK	DB00015	C1736H2671N499O522S22	biologic	B01AD07	133652-38-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
184	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Longstaff C (2008)	18673235	171788	15	Reteplase	t-plasminogen activator|tPA|Tissue-type plasminogen activator precursor|t- PA	retavase	DRUGBANK	DB00015	C1736H2671N499O522S22	biologic	B01AD07	133652-38-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
185	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Hilleman DE (2007)	17963464	171789	15	Reteplase	t-plasminogen activator|tPA|Tissue-type plasminogen activator precursor|t- PA	retavase	DRUGBANK	DB00015	C1736H2671N499O522S22	biologic	B01AD07	133652-38-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
192	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Chen X (2002)	11752352	171740	17	Salmon Calcitonin	Calcitonin, salmon|Calcitonin (Salmon Synthetic)|Fortical|Salmon calcitonin|Calcimar|Salmotonin|Cibacalcin|Miacalcin|Calcitonin salmon recombinant|Calcitonin 1 precursor|Calcitonin Salmon|Calcitonin-salmon|recombinant salmon calcitonin	caltine inj 100 unit/ml (1ml a	DRUGBANK	DB00017	C145H240N44O48S2	biologic	H05BA01	47931-85-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
193	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Sarkar A (1997)	9231703	171830	17	Salmon Calcitonin	Calcitonin, salmon|Calcitonin (Salmon Synthetic)|Fortical|Salmon calcitonin|Calcimar|Salmotonin|Cibacalcin|Miacalcin|Calcitonin salmon recombinant|Calcitonin 1 precursor|Calcitonin Salmon|Calcitonin-salmon|recombinant salmon calcitonin	caltine inj 100 unit/ml (1ml a	DRUGBANK	DB00017	C145H240N44O48S2	biologic	H05BA01	47931-85-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
194	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Stroop SD (1995)	7610922	171831	17	Salmon Calcitonin	Calcitonin, salmon|Calcitonin (Salmon Synthetic)|Fortical|Salmon calcitonin|Calcimar|Salmotonin|Cibacalcin|Miacalcin|Calcitonin salmon recombinant|Calcitonin 1 precursor|Calcitonin Salmon|Calcitonin-salmon|recombinant salmon calcitonin	caltine inj 100 unit/ml (1ml a	DRUGBANK	DB00017	C145H240N44O48S2	biologic	H05BA01	47931-85-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
195	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Bouizar Z (1986)	3004987	171832	17	Salmon Calcitonin	Calcitonin, salmon|Calcitonin (Salmon Synthetic)|Fortical|Salmon calcitonin|Calcimar|Salmotonin|Cibacalcin|Miacalcin|Calcitonin salmon recombinant|Calcitonin 1 precursor|Calcitonin Salmon|Calcitonin-salmon|recombinant salmon calcitonin	caltine inj 100 unit/ml (1ml a	DRUGBANK	DB00017	C145H240N44O48S2	biologic	H05BA01	47931-85-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
343	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	29	Anistreplase	t-plasminogen activator|tPA|Tissue-type plasminogen activator precursor|t- PA	eminase 30 units	DRUGBANK	DB00029	C2569H3928N746O781S40	biologic	B01AD03	81669-57-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
344	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	29	Anistreplase	t-plasminogen activator|tPA|Tissue-type plasminogen activator precursor|t- PA	eminase 30 units	DRUGBANK	DB00029	C2569H3928N746O781S40	biologic	B01AD03	81669-57-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
358	109711	3490	-	IGFBP7	AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	30	Insulin Human	Insulin human, rDNA origin|Regular Insulin, human|Insulin Human Regular|Insulin human regular (rDNA)|Human insulin|Insulin (human)|Insulin, human|Insulin human|Insulin regular|Insulin recombinant human|human insulin (rDNA)|Insulin human [rDNA origin]|Insulin recombinant purified human|High molecular weight insulin human	humulin r u-500 kwikpen|humuli	DRUGBANK	DB00030	C257H383N65O77S6	biologic	-	11061-68-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
359	109711	3490	-	IGFBP7	AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	30	Insulin Human	Insulin human, rDNA origin|Regular Insulin, human|Insulin Human Regular|Insulin human regular (rDNA)|Human insulin|Insulin (human)|Insulin, human|Insulin human|Insulin regular|Insulin recombinant human|human insulin (rDNA)|Insulin human [rDNA origin]|Insulin recombinant purified human|High molecular weight insulin human	humulin r u-500 kwikpen|humuli	DRUGBANK	DB00030	C257H383N65O77S6	biologic	-	11061-68-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
362	111860	5925	RP11-174I10.1	RB1	OSRC|PPP1R130|RB|p105-Rb|pRb|pp110	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	30	Insulin Human	Insulin human, rDNA origin|Regular Insulin, human|Insulin Human Regular|Insulin human regular (rDNA)|Human insulin|Insulin (human)|Insulin, human|Insulin human|Insulin regular|Insulin recombinant human|human insulin (rDNA)|Insulin human [rDNA origin]|Insulin recombinant purified human|High molecular weight insulin human	humulin r u-500 kwikpen|humuli	DRUGBANK	DB00030	C257H383N65O77S6	biologic	-	11061-68-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
363	111860	5925	RP11-174I10.1	RB1	OSRC|PPP1R130|RB|p105-Rb|pRb|pp110	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	30	Insulin Human	Insulin human, rDNA origin|Regular Insulin, human|Insulin Human Regular|Insulin human regular (rDNA)|Human insulin|Insulin (human)|Insulin, human|Insulin human|Insulin regular|Insulin recombinant human|human insulin (rDNA)|Insulin human [rDNA origin]|Insulin recombinant purified human|High molecular weight insulin human	humulin r u-500 kwikpen|humuli	DRUGBANK	DB00030	C257H383N65O77S6	biologic	-	11061-68-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
391	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Melandri G (2009)	19436656	171787	31	Tenecteplase	t-plasminogen activator|tPA|Tissue-type plasminogen activator precursor|t- PA	tnkase	DRUGBANK	DB00031	C2561H3919N747O781S40	biologic	B01AD11	191588-94-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
392	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Longstaff C (2008)	18673235	171788	31	Tenecteplase	t-plasminogen activator|tPA|Tissue-type plasminogen activator precursor|t- PA	tnkase	DRUGBANK	DB00031	C2561H3919N747O781S40	biologic	B01AD11	191588-94-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
393	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Hilleman DE (2007)	17963464	171789	31	Tenecteplase	t-plasminogen activator|tPA|Tissue-type plasminogen activator precursor|t- PA	tnkase	DRUGBANK	DB00031	C2561H3919N747O781S40	biologic	B01AD11	191588-94-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
469	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Lu W (1999)	10212269	171961	38	Palifermin	FGF-7|KGF|HBGF-7|Keratinocyte growth factor precursor|Fibroblast growth factor- 7	kepivance	DRUGBANK	DB00039	C721H1142N202O204S9	biologic	V03AF08	162394-19-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
470	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Sher I (2000)	10950949	3241	38	Palifermin	FGF-7|KGF|HBGF-7|Keratinocyte growth factor precursor|Fibroblast growth factor- 7	kepivance	DRUGBANK	DB00039	C721H1142N202O204S9	biologic	V03AF08	162394-19-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
471	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Wang F (1999)	9890894	171958	38	Palifermin	FGF-7|KGF|HBGF-7|Keratinocyte growth factor precursor|Fibroblast growth factor- 7	kepivance	DRUGBANK	DB00039	C721H1142N202O204S9	biologic	V03AF08	162394-19-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
472	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Matsubara A (1999)	11091737	171959	38	Palifermin	FGF-7|KGF|HBGF-7|Keratinocyte growth factor precursor|Fibroblast growth factor- 7	kepivance	DRUGBANK	DB00039	C721H1142N202O204S9	biologic	V03AF08	162394-19-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
473	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Ostrovsky O (2002)	11714710	171960	38	Palifermin	FGF-7|KGF|HBGF-7|Keratinocyte growth factor precursor|Fibroblast growth factor- 7	kepivance	DRUGBANK	DB00039	C721H1142N202O204S9	biologic	V03AF08	162394-19-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
577	107675	1278	-	COL1A2	OI4	9606	Homo sapiens	unknown	target	Chiu CJ (2002)	12101112	172028	47	Collagenase clostridium histolyticum	-	collagenase santyl|xiaflex	DRUGBANK	DB00048	C5028H7666N1300O1564S21	biologic	M09AB02	9001-12-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
658	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	53	Abciximab	7E3|7E3 antibody|antiGPIIBIIIa|C7E3	reopro	DRUGBANK	DB00054	C6462H9964N1690O2049S48	biologic	B01AC13	143653-53-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
659	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Hall PR (2007)	17441904	172060	53	Abciximab	7E3|7E3 antibody|antiGPIIBIIIa|C7E3	reopro	DRUGBANK	DB00054	C6462H9964N1690O2049S48	biologic	B01AC13	143653-53-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
660	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Ibbotson T (2003)	12749745	172056	53	Abciximab	7E3|7E3 antibody|antiGPIIBIIIa|C7E3	reopro	DRUGBANK	DB00054	C6462H9964N1690O2049S48	biologic	B01AC13	143653-53-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
661	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Mazzaferri EL (2008)	18510478	172055	53	Abciximab	7E3|7E3 antibody|antiGPIIBIIIa|C7E3	reopro	DRUGBANK	DB00054	C6462H9964N1690O2049S48	biologic	B01AC13	143653-53-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
662	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Amoroso G (2001)	11588534	172059	53	Abciximab	7E3|7E3 antibody|antiGPIIBIIIa|C7E3	reopro	DRUGBANK	DB00054	C6462H9964N1690O2049S48	biologic	B01AC13	143653-53-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
663	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Weber AA (2002)	12165285	172058	53	Abciximab	7E3|7E3 antibody|antiGPIIBIIIa|C7E3	reopro	DRUGBANK	DB00054	C6462H9964N1690O2049S48	biologic	B01AC13	143653-53-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
683	108452	2153	-	F5	FVL|PCCF|RPRGL1|THPH2	9606	Homo sapiens	multitarget	target	Poe K (2002)	12030642	172079	54	Drotrecogin alfa	Drotrecogin alfa activated|Blood coagulation factor XIV (human)|Drotrecogin-alfa|Recombinant human activated protein C (rH-APC)|Activated protein C|Drotrecogin alfa (activated)|Drotrecogin alfa, activated|Drotrecogin alfa (activated), lyophilized	xigris (5mg/vial)|xigris  (20m	DRUGBANK	DB00055	C1786H2779N509O519S29	biologic	B01AD10	98530-76-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
684	108452	2153	-	F5	FVL|PCCF|RPRGL1|THPH2	9606	Homo sapiens	multitarget	target	Bernard GR (2001)	11236773	172078	54	Drotrecogin alfa	Drotrecogin alfa activated|Blood coagulation factor XIV (human)|Drotrecogin-alfa|Recombinant human activated protein C (rH-APC)|Activated protein C|Drotrecogin alfa (activated)|Drotrecogin alfa, activated|Drotrecogin alfa (activated), lyophilized	xigris (5mg/vial)|xigris  (20m	DRUGBANK	DB00055	C1786H2779N509O519S29	biologic	B01AD10	98530-76-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
685	108452	2153	-	F5	FVL|PCCF|RPRGL1|THPH2	9606	Homo sapiens	multitarget	target	Joyce DE (2002)	12004250	172075	54	Drotrecogin alfa	Drotrecogin alfa activated|Blood coagulation factor XIV (human)|Drotrecogin-alfa|Recombinant human activated protein C (rH-APC)|Activated protein C|Drotrecogin alfa (activated)|Drotrecogin alfa, activated|Drotrecogin alfa (activated), lyophilized	xigris (5mg/vial)|xigris  (20m	DRUGBANK	DB00055	C1786H2779N509O519S29	biologic	B01AD10	98530-76-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
686	108452	2153	-	F5	FVL|PCCF|RPRGL1|THPH2	9606	Homo sapiens	multitarget	target	Chen X (2002)	11752352	171740	54	Drotrecogin alfa	Drotrecogin alfa activated|Blood coagulation factor XIV (human)|Drotrecogin-alfa|Recombinant human activated protein C (rH-APC)|Activated protein C|Drotrecogin alfa (activated)|Drotrecogin alfa, activated|Drotrecogin alfa (activated), lyophilized	xigris (5mg/vial)|xigris  (20m	DRUGBANK	DB00055	C1786H2779N509O519S29	biologic	B01AD10	98530-76-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
687	108452	2153	-	F5	FVL|PCCF|RPRGL1|THPH2	9606	Homo sapiens	multitarget	target	Kanji S (2001)	11714212	172076	54	Drotrecogin alfa	Drotrecogin alfa activated|Blood coagulation factor XIV (human)|Drotrecogin-alfa|Recombinant human activated protein C (rH-APC)|Activated protein C|Drotrecogin alfa (activated)|Drotrecogin alfa, activated|Drotrecogin alfa (activated), lyophilized	xigris (5mg/vial)|xigris  (20m	DRUGBANK	DB00055	C1786H2779N509O519S29	biologic	B01AD10	98530-76-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
688	108452	2153	-	F5	FVL|PCCF|RPRGL1|THPH2	9606	Homo sapiens	multitarget	target	Lyseng-Williamson KA (2002)	11893230	172077	54	Drotrecogin alfa	Drotrecogin alfa activated|Blood coagulation factor XIV (human)|Drotrecogin-alfa|Recombinant human activated protein C (rH-APC)|Activated protein C|Drotrecogin alfa (activated)|Drotrecogin alfa, activated|Drotrecogin alfa (activated), lyophilized	xigris (5mg/vial)|xigris  (20m	DRUGBANK	DB00055	C1786H2779N509O519S29	biologic	B01AD10	98530-76-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
755	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Schroer K (2003)	14618072	172126	62	Eptifibatide	Intrifiban|Integrelin	eptifibatide|eptifibatide inje	DRUGBANK	DB00063	C35H49N11O9S2	biologic	B01AC16	188627-80-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
756	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Schwarz M (2004)	14617694	172125	62	Eptifibatide	Intrifiban|Integrelin	eptifibatide|eptifibatide inje	DRUGBANK	DB00063	C35H49N11O9S2	biologic	B01AC16	188627-80-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
757	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Fischer TH (2005)	15860200	172124	62	Eptifibatide	Intrifiban|Integrelin	eptifibatide|eptifibatide inje	DRUGBANK	DB00063	C35H49N11O9S2	biologic	B01AC16	188627-80-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
758	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Auer J (2003)	12928738	172123	62	Eptifibatide	Intrifiban|Integrelin	eptifibatide|eptifibatide inje	DRUGBANK	DB00063	C35H49N11O9S2	biologic	B01AC16	188627-80-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
759	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	62	Eptifibatide	Intrifiban|Integrelin	eptifibatide|eptifibatide inje	DRUGBANK	DB00063	C35H49N11O9S2	biologic	B01AC16	188627-80-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
760	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Weber AA (2002)	12360110	172121	62	Eptifibatide	Intrifiban|Integrelin	eptifibatide|eptifibatide inje	DRUGBANK	DB00063	C35H49N11O9S2	biologic	B01AC16	188627-80-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
761	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Amoroso G (2001)	11588534	172059	62	Eptifibatide	Intrifiban|Integrelin	eptifibatide|eptifibatide inje	DRUGBANK	DB00063	C35H49N11O9S2	biologic	B01AC16	188627-80-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
829	109711	3490	-	IGFBP7	AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF	9606	Homo sapiens	unknown	target	Radulescu RT (2007)	17475416	172174	70	Insulin Pork	Insulin (pork)|Insulin, regular, pork|Insulin purified porcine|Porcine insulin|Insulin purified pork|Insulin, porcine|Insulin porcine	-	DRUGBANK	DB00071	C257H387N65O76S6	biologic	A10AE03|A10AD03|A10AC03|A10AB03	12584-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
830	109711	3490	-	IGFBP7	AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF	9606	Homo sapiens	unknown	target	Degeorges A (1999)	10383131	172175	70	Insulin Pork	Insulin (pork)|Insulin, regular, pork|Insulin purified porcine|Porcine insulin|Insulin purified pork|Insulin, porcine|Insulin porcine	-	DRUGBANK	DB00071	C257H387N65O76S6	biologic	A10AE03|A10AD03|A10AC03|A10AB03	12584-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
831	109711	3490	-	IGFBP7	AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF	9606	Homo sapiens	unknown	target	Lopez-Bermejo A (2000)	11089538	172176	70	Insulin Pork	Insulin (pork)|Insulin, regular, pork|Insulin purified porcine|Porcine insulin|Insulin purified pork|Insulin, porcine|Insulin porcine	-	DRUGBANK	DB00071	C257H387N65O76S6	biologic	A10AE03|A10AD03|A10AC03|A10AB03	12584-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
832	109711	3490	-	IGFBP7	AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	70	Insulin Pork	Insulin (pork)|Insulin, regular, pork|Insulin purified porcine|Porcine insulin|Insulin purified pork|Insulin, porcine|Insulin porcine	-	DRUGBANK	DB00071	C257H387N65O76S6	biologic	A10AE03|A10AD03|A10AC03|A10AB03	12584-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
833	109711	3490	-	IGFBP7	AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	70	Insulin Pork	Insulin (pork)|Insulin, regular, pork|Insulin purified porcine|Porcine insulin|Insulin purified pork|Insulin, porcine|Insulin porcine	-	DRUGBANK	DB00071	C257H387N65O76S6	biologic	A10AE03|A10AD03|A10AC03|A10AB03	12584-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
839	111860	5925	RP11-174I10.1	RB1	OSRC|PPP1R130|RB|p105-Rb|pRb|pp110	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	70	Insulin Pork	Insulin (pork)|Insulin, regular, pork|Insulin purified porcine|Porcine insulin|Insulin purified pork|Insulin, porcine|Insulin porcine	-	DRUGBANK	DB00071	C257H387N65O76S6	biologic	A10AE03|A10AD03|A10AC03|A10AB03	12584-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
840	111860	5925	RP11-174I10.1	RB1	OSRC|PPP1R130|RB|p105-Rb|pRb|pp110	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	70	Insulin Pork	Insulin (pork)|Insulin, regular, pork|Insulin purified porcine|Porcine insulin|Insulin purified pork|Insulin, porcine|Insulin porcine	-	DRUGBANK	DB00071	C257H387N65O76S6	biologic	A10AE03|A10AD03|A10AC03|A10AB03	12584-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
841	111860	5925	RP11-174I10.1	RB1	OSRC|PPP1R130|RB|p105-Rb|pRb|pp110	9606	Homo sapiens	unknown	target	Biener Y (1990)	1701386	172180	70	Insulin Pork	Insulin (pork)|Insulin, regular, pork|Insulin purified porcine|Porcine insulin|Insulin purified pork|Insulin, porcine|Insulin porcine	-	DRUGBANK	DB00071	C257H387N65O76S6	biologic	A10AE03|A10AD03|A10AC03|A10AB03	12584-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
886	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antibody	target	Chen X (2002)	11752352	171740	71	Trastuzumab	Anti HER2|Ig gamma-1 chain C region	herceptin|perjeta-herceptin	DRUGBANK	DB00072	C6470H10012N1726O2013S42	biologic	L01XC03	180288-69-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
887	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antibody	target	Lin A (2007)	17660958	172202	71	Trastuzumab	Anti HER2|Ig gamma-1 chain C region	herceptin|perjeta-herceptin	DRUGBANK	DB00072	C6470H10012N1726O2013S42	biologic	L01XC03	180288-69-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
888	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antibody	target	Treish I (2000)	11098307	172203	71	Trastuzumab	Anti HER2|Ig gamma-1 chain C region	herceptin|perjeta-herceptin	DRUGBANK	DB00072	C6470H10012N1726O2013S42	biologic	L01XC03	180288-69-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
889	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antibody	target	Leveque D (2008)	18690878	172201	71	Trastuzumab	Anti HER2|Ig gamma-1 chain C region	herceptin|perjeta-herceptin	DRUGBANK	DB00072	C6470H10012N1726O2013S42	biologic	L01XC03	180288-69-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
893	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	unknown	target	Chen X (2002)	11752352	171740	71	Trastuzumab	Anti HER2|Ig gamma-1 chain C region	herceptin|perjeta-herceptin	DRUGBANK	DB00072	C6470H10012N1726O2013S42	biologic	L01XC03	180288-69-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1206	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Monti P (2003)	12586600	172372	94	Anti-thymocyte Globulin (Rabbit)	rabbit ATG|rATG|Thymoglobulin|Anti-thymocyte globulin (rabbit)	thymoglobulin	DRUGBANK	DB00098	-	biologic	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1253	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	unknown	target	Ebert M (1995)	7665222	172401	97	Becaplermin	PDGFB|SH-POLYPEPTIDE-59|c-sis|PDGF-BB|PDGF-2|Platelet-derived growth factor beta polypeptide|PDGF B-chain|Platelet-derived growth factor B chain precursor	regranex (becaplermin) 0.01%|r	DRUGBANK	DB00102	C532H892N162O153S9	biologic	A01AD08|D03AX06	165101-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1254	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	unknown	target	Heidaran MA (1991)	1702511	172402	97	Becaplermin	PDGFB|SH-POLYPEPTIDE-59|c-sis|PDGF-BB|PDGF-2|Platelet-derived growth factor beta polypeptide|PDGF B-chain|Platelet-derived growth factor B chain precursor	regranex (becaplermin) 0.01%|r	DRUGBANK	DB00102	C532H892N162O153S9	biologic	A01AD08|D03AX06	165101-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1255	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	unknown	target	Abdiu A (1998)	10070317	172403	97	Becaplermin	PDGFB|SH-POLYPEPTIDE-59|c-sis|PDGF-BB|PDGF-2|Platelet-derived growth factor beta polypeptide|PDGF B-chain|Platelet-derived growth factor B chain precursor	regranex (becaplermin) 0.01%|r	DRUGBANK	DB00102	C532H892N162O153S9	biologic	A01AD08|D03AX06	165101-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1256	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	unknown	target	Miller-Kasprzak E (2003)	12632922	172404	97	Becaplermin	PDGFB|SH-POLYPEPTIDE-59|c-sis|PDGF-BB|PDGF-2|Platelet-derived growth factor beta polypeptide|PDGF B-chain|Platelet-derived growth factor B chain precursor	regranex (becaplermin) 0.01%|r	DRUGBANK	DB00102	C532H892N162O153S9	biologic	A01AD08|D03AX06	165101-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1257	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	unknown	target	Yu J (2003)	14506245	172405	97	Becaplermin	PDGFB|SH-POLYPEPTIDE-59|c-sis|PDGF-BB|PDGF-2|Platelet-derived growth factor beta polypeptide|PDGF B-chain|Platelet-derived growth factor B chain precursor	regranex (becaplermin) 0.01%|r	DRUGBANK	DB00102	C532H892N162O153S9	biologic	A01AD08|D03AX06	165101-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1258	106524	2	-	A2M	A2MD|CPAMD5|FWP007|S863-7	9606	Homo sapiens	unknown	target	Bonner JC (1995)	7541796	172406	97	Becaplermin	PDGFB|SH-POLYPEPTIDE-59|c-sis|PDGF-BB|PDGF-2|Platelet-derived growth factor beta polypeptide|PDGF B-chain|Platelet-derived growth factor B chain precursor	regranex (becaplermin) 0.01%|r	DRUGBANK	DB00102	C532H892N162O153S9	biologic	A01AD08|D03AX06	165101-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1259	106524	2	-	A2M	A2MD|CPAMD5|FWP007|S863-7	9606	Homo sapiens	unknown	target	Lizonova A (1990)	1697862	172407	97	Becaplermin	PDGFB|SH-POLYPEPTIDE-59|c-sis|PDGF-BB|PDGF-2|Platelet-derived growth factor beta polypeptide|PDGF B-chain|Platelet-derived growth factor B chain precursor	regranex (becaplermin) 0.01%|r	DRUGBANK	DB00102	C532H892N162O153S9	biologic	A01AD08|D03AX06	165101-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
2368	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	unknown	target	Rutter AR (2000)	11080203	173223	136	L-Glutamic Acid	(S)-Glutamic acid|(2S)-2-Aminopentanedioic acid|L-Glutamate|Glutamic acid|(S)-2-Aminopentanedioic acid|L-Glutaminic acid|Glu	primene 10%|aminosyn ii 5% inj	DRUGBANK	DB00142	C5H9NO4	small molecule	-	56-86-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WHUUTDBJXJRKMK-VKHMYHEASA-N
2369	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	136	L-Glutamic Acid	(S)-Glutamic acid|(2S)-2-Aminopentanedioic acid|L-Glutamate|Glutamic acid|(S)-2-Aminopentanedioic acid|L-Glutaminic acid|Glu	primene 10%|aminosyn ii 5% inj	DRUGBANK	DB00142	C5H9NO4	small molecule	-	56-86-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WHUUTDBJXJRKMK-VKHMYHEASA-N
2370	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	136	L-Glutamic Acid	(S)-Glutamic acid|(2S)-2-Aminopentanedioic acid|L-Glutamate|Glutamic acid|(S)-2-Aminopentanedioic acid|L-Glutaminic acid|Glu	primene 10%|aminosyn ii 5% inj	DRUGBANK	DB00142	C5H9NO4	small molecule	-	56-86-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WHUUTDBJXJRKMK-VKHMYHEASA-N
2371	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	unknown	target	Rutter AR (2002)	12068077	173225	136	L-Glutamic Acid	(S)-Glutamic acid|(2S)-2-Aminopentanedioic acid|L-Glutamate|Glutamic acid|(S)-2-Aminopentanedioic acid|L-Glutaminic acid|Glu	primene 10%|aminosyn ii 5% inj	DRUGBANK	DB00142	C5H9NO4	small molecule	-	56-86-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WHUUTDBJXJRKMK-VKHMYHEASA-N
2372	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	unknown	target	Bresink I (1996)	8886398	173224	136	L-Glutamic Acid	(S)-Glutamic acid|(2S)-2-Aminopentanedioic acid|L-Glutamate|Glutamic acid|(S)-2-Aminopentanedioic acid|L-Glutaminic acid|Glu	primene 10%|aminosyn ii 5% inj	DRUGBANK	DB00142	C5H9NO4	small molecule	-	56-86-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WHUUTDBJXJRKMK-VKHMYHEASA-N
2768	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	139	Glycine	Aminoacetic acid|Glycine|G|Glycin|Aminoessigsaeure|Hgly|Glycocoll|Gly|Aminoethanoic acid|Leimzucker|Glyzin|H2N-CH2-COOH|Glykokoll	2.5% travasol amino acid injec	DRUGBANK	DB00145	C2H5NO2	small molecule	B05CX03	56-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DHMQDGOQFOQNFH-UHFFFAOYSA-N
2769	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Milutinovic PS (2007)	17646495	173458	139	Glycine	Aminoacetic acid|Glycine|G|Glycin|Aminoessigsaeure|Hgly|Glycocoll|Gly|Aminoethanoic acid|Leimzucker|Glyzin|H2N-CH2-COOH|Glykokoll	2.5% travasol amino acid injec	DRUGBANK	DB00145	C2H5NO2	small molecule	B05CX03	56-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DHMQDGOQFOQNFH-UHFFFAOYSA-N
2770	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Gabra BH (2007)	17405869	173454	139	Glycine	Aminoacetic acid|Glycine|G|Glycin|Aminoessigsaeure|Hgly|Glycocoll|Gly|Aminoethanoic acid|Leimzucker|Glyzin|H2N-CH2-COOH|Glykokoll	2.5% travasol amino acid injec	DRUGBANK	DB00145	C2H5NO2	small molecule	B05CX03	56-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DHMQDGOQFOQNFH-UHFFFAOYSA-N
2771	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Brosnan RJ (2007)	17513636	173455	139	Glycine	Aminoacetic acid|Glycine|G|Glycin|Aminoessigsaeure|Hgly|Glycocoll|Gly|Aminoethanoic acid|Leimzucker|Glyzin|H2N-CH2-COOH|Glykokoll	2.5% travasol amino acid injec	DRUGBANK	DB00145	C2H5NO2	small molecule	B05CX03	56-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DHMQDGOQFOQNFH-UHFFFAOYSA-N
2772	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Liu Y (2007)	17360906	173456	139	Glycine	Aminoacetic acid|Glycine|G|Glycin|Aminoessigsaeure|Hgly|Glycocoll|Gly|Aminoethanoic acid|Leimzucker|Glyzin|H2N-CH2-COOH|Glykokoll	2.5% travasol amino acid injec	DRUGBANK	DB00145	C2H5NO2	small molecule	B05CX03	56-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DHMQDGOQFOQNFH-UHFFFAOYSA-N
2773	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Domingues A (2007)	17403555	173457	139	Glycine	Aminoacetic acid|Glycine|G|Glycin|Aminoessigsaeure|Hgly|Glycocoll|Gly|Aminoethanoic acid|Leimzucker|Glyzin|H2N-CH2-COOH|Glykokoll	2.5% travasol amino acid injec	DRUGBANK	DB00145	C2H5NO2	small molecule	B05CX03	56-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DHMQDGOQFOQNFH-UHFFFAOYSA-N
3689	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Blume H (2006)	16944963	174014	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3690	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Fukui N (2007)	17417072	174011	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3691	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Gardner ER (2006)	16890580	174010	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3692	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Lage H (2006)	16842213	174013	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3693	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Gervasini G (2006)	17120199	174012	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3715	115371	10060	-	ABCC9	ABC37|ATFB12|CANTU|CMD1O|SUR2	9606	Homo sapiens	unknown	target	Zhao JL (2006)	16845255	174020	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3716	115371	10060	-	ABCC9	ABC37|ATFB12|CANTU|CMD1O|SUR2	9606	Homo sapiens	unknown	target	Yang YJ (2007)	16829188	174021	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3717	115371	10060	-	ABCC9	ABC37|ATFB12|CANTU|CMD1O|SUR2	9606	Homo sapiens	unknown	target	Bryan J (2007)	16897043	174022	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3747	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3748	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3822	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Singh V (2006)	17090056	174051	166	Adenine	A|6-Aminopurine|ADENINE|Adenin|Ade|Vitamin B4	nutricel additive system - as3	DRUGBANK	DB00173	C5H5N5	small molecule	-	73-24-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GFFGJBXGBJISGV-UHFFFAOYSA-N
3823	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Chow WA (2006)	16631464	174053	166	Adenine	A|6-Aminopurine|ADENINE|Adenin|Ade|Vitamin B4	nutricel additive system - as3	DRUGBANK	DB00173	C5H5N5	small molecule	-	73-24-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GFFGJBXGBJISGV-UHFFFAOYSA-N
3824	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Chattopadhyay S (2006)	17041099	174052	166	Adenine	A|6-Aminopurine|ADENINE|Adenin|Ade|Vitamin B4	nutricel additive system - as3	DRUGBANK	DB00173	C5H5N5	small molecule	-	73-24-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GFFGJBXGBJISGV-UHFFFAOYSA-N
3961	107528	1103	-	CHAT	CHOACTASE|CMS1A|CMS1A2	9606	Homo sapiens	unknown	target	FAHMY AR (1954)	13192619	174187	177	Nicotine	(S)-3-(N-methylpyrrolidin-2-yl)pyridine|(S)-3-(1-methylpyrrolidin-2-yl)pyridine|L()-nicotine|()-nicotine|(S)-Nicotine|3-(2-(N-methylpyrrolidinyl))pyridine|(S)-()-nicotine|3-(N-methylpyrollidino)pyridine	good neighbor pharmacy nicotin	DRUGBANK	DB00184	C10H14N2	small molecule	N07BA01	54-11-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SNICXCGAKADSCV-JTQLQIEISA-N
4010	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	179	Lorazepam	Lormetazepam|Ativan|O-Chlorooxazepam|Methyllorazepam|()-Lorazepam|N-Methyllorazepam|O-Chloroxazepam	pms-lorazepam tab 0.5mg|apo-lo	DRUGBANK	DB00186	C15H10Cl2N2O2	small molecule	N05BA06|N05CD06|N05BA56	846-49-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DIWRORZWFLOCLC-UHFFFAOYSA-N
4016	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	179	Lorazepam	Lormetazepam|Ativan|O-Chlorooxazepam|Methyllorazepam|()-Lorazepam|N-Methyllorazepam|O-Chloroxazepam	pms-lorazepam tab 0.5mg|apo-lo	DRUGBANK	DB00186	C15H10Cl2N2O2	small molecule	N05BA06|N05CD06|N05BA56	846-49-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DIWRORZWFLOCLC-UHFFFAOYSA-N
4052	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Smeyatsky N (1992)	1585214	174217	182	Ethchlorvynol	3-(beta-chlorovinyl)-1-pentyn-3-ol|Placidyl|1-chloro-3-ethyl-1-penten-4-yn-3-ol|ethyl -chlorovinyl ethynyl carbinol|1-Chloro-3-ethyl-pent-1-en-4-yn-3-ol|3-(-chlorovinyl)-1-pentyn-3-ol|-chlorovinyl ethyl ethynyl carbinol	placidyl cap 200mg|placidyl ca	DRUGBANK	DB00189	C7H9ClO	small molecule	N05CM08	113-18-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZEHYJZXQEQOSON-AATRIKPKSA-N
4058	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Smeyatsky N (1992)	1585214	174217	182	Ethchlorvynol	3-(beta-chlorovinyl)-1-pentyn-3-ol|Placidyl|1-chloro-3-ethyl-1-penten-4-yn-3-ol|ethyl -chlorovinyl ethynyl carbinol|1-Chloro-3-ethyl-pent-1-en-4-yn-3-ol|3-(-chlorovinyl)-1-pentyn-3-ol|-chlorovinyl ethyl ethynyl carbinol	placidyl cap 200mg|placidyl ca	DRUGBANK	DB00189	C7H9ClO	small molecule	N05CM08	113-18-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZEHYJZXQEQOSON-AATRIKPKSA-N
4259	111308	5290	-	PIK3CA	CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha	9606	Homo sapiens	unknown	target	Foukas LC (2002)	12145276	174346	194	Caffeine	Cafine|1,3,7-trimethylpurine-2,6-dione|Theine|7-methyltheophylline|Coffein|Methyltheobromine|Koffein|Guaranine|1-methyltheobromine|Thein|tena|1,3,7-trimethyl-2,6-dioxopurine|Coffeinum|Anhydrous caffeine|Matena|1,3,7-trimethylxanthine|Caffeinum|Cafena|3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion	stay awake maximum strength|fi	DRUGBANK	DB00201	C8H10N4O2	small molecule	N06BC01|V04CG30	58-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RYYVLZVUVIJVGH-UHFFFAOYSA-N
4340	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	205	Remikiren	-	-	DRUGBANK	DB00212	C33H50N4O6S	small molecule	C09XA01	126222-34-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXIGZRQVLGFTOU-VQXQMPIVSA-N
4341	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	van Paassen P (1999)	10583449	174413	205	Remikiren	-	-	DRUGBANK	DB00212	C33H50N4O6S	small molecule	C09XA01	126222-34-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXIGZRQVLGFTOU-VQXQMPIVSA-N
4342	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Hilgers KF (1994)	8206619	174415	205	Remikiren	-	-	DRUGBANK	DB00212	C33H50N4O6S	small molecule	C09XA01	126222-34-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXIGZRQVLGFTOU-VQXQMPIVSA-N
4343	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Kiowski W (1994)	7994817	174414	205	Remikiren	-	-	DRUGBANK	DB00212	C33H50N4O6S	small molecule	C09XA01	126222-34-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXIGZRQVLGFTOU-VQXQMPIVSA-N
4344	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Clozel JP (1993)	8319997	174417	205	Remikiren	-	-	DRUGBANK	DB00212	C33H50N4O6S	small molecule	C09XA01	126222-34-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXIGZRQVLGFTOU-VQXQMPIVSA-N
4345	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	MacFadyen RJ (1995)	7769797	174416	205	Remikiren	-	-	DRUGBANK	DB00212	C33H50N4O6S	small molecule	C09XA01	126222-34-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXIGZRQVLGFTOU-VQXQMPIVSA-N
4456	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Grasshoff C (2006)	16973644	174521	221	Enflurane	Efrane|Enflurane|Alyrane|Ethrane|Enflurano|2-chloro-1,1,2-trifluoroethyl difluoromethyl ether|Enfluranum|Methylflurether	enflurane|ethrane liq inh|ethr	DRUGBANK	DB00228	C3H2ClF5O	small molecule	N01AB04	13838-16-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JPGQOUSTVILISH-UHFFFAOYSA-N
4457	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Greenblatt EP (2001)	11465594	174520	221	Enflurane	Efrane|Enflurane|Alyrane|Ethrane|Enflurano|2-chloro-1,1,2-trifluoroethyl difluoromethyl ether|Enfluranum|Methylflurether	enflurane|ethrane liq inh|ethr	DRUGBANK	DB00228	C3H2ClF5O	small molecule	N01AB04	13838-16-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JPGQOUSTVILISH-UHFFFAOYSA-N
4458	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Franks NP (2006)	16402123	174522	221	Enflurane	Efrane|Enflurane|Alyrane|Ethrane|Enflurano|2-chloro-1,1,2-trifluoroethyl difluoromethyl ether|Enfluranum|Methylflurether	enflurane|ethrane liq inh|ethr	DRUGBANK	DB00228	C3H2ClF5O	small molecule	N01AB04	13838-16-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JPGQOUSTVILISH-UHFFFAOYSA-N
4474	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Grasshoff C (2006)	16973644	174521	221	Enflurane	Efrane|Enflurane|Alyrane|Ethrane|Enflurano|2-chloro-1,1,2-trifluoroethyl difluoromethyl ether|Enfluranum|Methylflurether	enflurane|ethrane liq inh|ethr	DRUGBANK	DB00228	C3H2ClF5O	small molecule	N01AB04	13838-16-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JPGQOUSTVILISH-UHFFFAOYSA-N
4475	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Greenblatt EP (2001)	11465594	174520	221	Enflurane	Efrane|Enflurane|Alyrane|Ethrane|Enflurano|2-chloro-1,1,2-trifluoroethyl difluoromethyl ether|Enfluranum|Methylflurether	enflurane|ethrane liq inh|ethr	DRUGBANK	DB00228	C3H2ClF5O	small molecule	N01AB04	13838-16-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JPGQOUSTVILISH-UHFFFAOYSA-N
4476	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Franks NP (2006)	16402123	174522	221	Enflurane	Efrane|Enflurane|Alyrane|Ethrane|Enflurano|2-chloro-1,1,2-trifluoroethyl difluoromethyl ether|Enfluranum|Methylflurether	enflurane|ethrane liq inh|ethr	DRUGBANK	DB00228	C3H2ClF5O	small molecule	N01AB04	13838-16-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JPGQOUSTVILISH-UHFFFAOYSA-N
4513	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	224	Temazepam	Restoril	strazepam|nu-temazepam|phl-tem	DRUGBANK	DB00231	C16H13ClN2O2	small molecule	N05CD07	846-50-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SEQDDYPDSLOBDC-UHFFFAOYSA-N
4514	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Giersch A (2010)	20138190	174534	224	Temazepam	Restoril	strazepam|nu-temazepam|phl-tem	DRUGBANK	DB00231	C16H13ClN2O2	small molecule	N05CD07	846-50-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SEQDDYPDSLOBDC-UHFFFAOYSA-N
4521	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	224	Temazepam	Restoril	strazepam|nu-temazepam|phl-tem	DRUGBANK	DB00231	C16H13ClN2O2	small molecule	N05CD07	846-50-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SEQDDYPDSLOBDC-UHFFFAOYSA-N
4522	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Giersch A (2010)	20138190	174534	224	Temazepam	Restoril	strazepam|nu-temazepam|phl-tem	DRUGBANK	DB00231	C16H13ClN2O2	small molecule	N05CD07	846-50-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SEQDDYPDSLOBDC-UHFFFAOYSA-N
4589	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Mehta AK (1999)	10209232	174569	230	Butabarbital	Secbutabarbital|5-Sec-butyl-5-ethylbarbituric acid|5-Sec-butyl-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione|5-Sec-butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Butisol|5-Ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-(1-methylpropyl)barbituric acid|Butabarbital	butisol sodium tab 30mg|butiso	DRUGBANK	DB00237	C10H16N2O3	small molecule	-	125-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZRIHAIZYIMGOAB-UHFFFAOYSA-N
4590	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Yamakura T (2001)	11264449	174568	230	Butabarbital	Secbutabarbital|5-Sec-butyl-5-ethylbarbituric acid|5-Sec-butyl-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione|5-Sec-butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Butisol|5-Ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-(1-methylpropyl)barbituric acid|Butabarbital	butisol sodium tab 30mg|butiso	DRUGBANK	DB00237	C10H16N2O3	small molecule	-	125-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZRIHAIZYIMGOAB-UHFFFAOYSA-N
4601	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Mehta AK (1999)	10209232	174569	230	Butabarbital	Secbutabarbital|5-Sec-butyl-5-ethylbarbituric acid|5-Sec-butyl-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione|5-Sec-butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Butisol|5-Ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-(1-methylpropyl)barbituric acid|Butabarbital	butisol sodium tab 30mg|butiso	DRUGBANK	DB00237	C10H16N2O3	small molecule	-	125-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZRIHAIZYIMGOAB-UHFFFAOYSA-N
4602	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Yamakura T (2001)	11264449	174568	230	Butabarbital	Secbutabarbital|5-Sec-butyl-5-ethylbarbituric acid|5-Sec-butyl-5-ethylpyrimidine-2,4,6(1H,3H,5H)-trione|5-Sec-butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Butisol|5-Ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-(1-methylpropyl)barbituric acid|Butabarbital	butisol sodium tab 30mg|butiso	DRUGBANK	DB00237	C10H16N2O3	small molecule	-	125-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZRIHAIZYIMGOAB-UHFFFAOYSA-N
4648	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	234	Butalbital	allylbarbital|Butalbarbital|5-Allyl-5-(2-methylpropyl)barbituric acid|Itobarbital|Butalbitalum|allylbarbitone|5-isobutyl-5-allylbarbituric acid|Tetrallobarbital|5-(2-methylpropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione|5-Allyl-5-(2'-methyl-N-propyl) barbituric acid|5-Allyl-5-isobutylbarbituric acid|5-Allyl-5-isobutyl-pyrimidine-2,4,6-trione|5-Allyl-5-isobutyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Allylbarbituric acid|Iso-butylallylbarbituric acid	allzital|ratio-tecnal c 1/4|ra	DRUGBANK	DB00241	C11H16N2O3	small molecule	-	77-26-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UZVHFVZFNXBMQJ-UHFFFAOYSA-N
4649	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	234	Butalbital	allylbarbital|Butalbarbital|5-Allyl-5-(2-methylpropyl)barbituric acid|Itobarbital|Butalbitalum|allylbarbitone|5-isobutyl-5-allylbarbituric acid|Tetrallobarbital|5-(2-methylpropyl)-5-prop-2-enyl-1,3-diazinane-2,4,6-trione|5-Allyl-5-(2'-methyl-N-propyl) barbituric acid|5-Allyl-5-isobutylbarbituric acid|5-Allyl-5-isobutyl-pyrimidine-2,4,6-trione|5-Allyl-5-isobutyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Allylbarbituric acid|Iso-butylallylbarbituric acid	allzital|ratio-tecnal c 1/4|ra	DRUGBANK	DB00241	C11H16N2O3	small molecule	-	77-26-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UZVHFVZFNXBMQJ-UHFFFAOYSA-N
4687	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Rajamani S (2008)	19077543	174602	236	Ranolazine	-	ranexa	DRUGBANK	DB00243	C24H33N3O4	small molecule	C01EB18	95635-55-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XKLMZUWKNUAPSZ-UHFFFAOYSA-N
4688	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	236	Ranolazine	-	ranexa	DRUGBANK	DB00243	C24H33N3O4	small molecule	C01EB18	95635-55-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XKLMZUWKNUAPSZ-UHFFFAOYSA-N
4749	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Nasrallah HA (2008)	17848919	174616	239	Ziprasidone	Ziprasidone|Ziprasidona|Ziprasidonum	zeldox|ziprasidone hydrochlori	DRUGBANK	DB00246	C21H21ClN4OS	small molecule	N05AE04	146939-27-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MVWVFYHBGMAFLY-UHFFFAOYSA-N
4829	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Kvernmo T (2008)	18691132	174662	241	Cabergoline	(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide|1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea|Cabergolinum|Cabergolina|1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea|1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea|Cabergoline|(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide	apo-cabergoline|cabergoline|ac	DRUGBANK	DB00248	C26H37N5O2	small molecule	G02CB03|N04BC06	81409-90-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KORNTPPJEAJQIU-KJXAQDMKSA-N
4830	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Kvernmo T (2006)	16982285	174668	241	Cabergoline	(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide|1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea|Cabergolinum|Cabergolina|1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea|1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea|Cabergoline|(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide	apo-cabergoline|cabergoline|ac	DRUGBANK	DB00248	C26H37N5O2	small molecule	G02CB03|N04BC06	81409-90-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KORNTPPJEAJQIU-KJXAQDMKSA-N
4831	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Ichikawa K (2001)	11436517	174659	241	Cabergoline	(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide|1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea|Cabergolinum|Cabergolina|1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea|1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea|Cabergoline|(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide	apo-cabergoline|cabergoline|ac	DRUGBANK	DB00248	C26H37N5O2	small molecule	G02CB03|N04BC06	81409-90-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KORNTPPJEAJQIU-KJXAQDMKSA-N
4844	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Millan MJ (2002)	12388666	174654	241	Cabergoline	(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide|1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea|Cabergolinum|Cabergolina|1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea|1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea|Cabergoline|(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide	apo-cabergoline|cabergoline|ac	DRUGBANK	DB00248	C26H37N5O2	small molecule	G02CB03|N04BC06	81409-90-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KORNTPPJEAJQIU-KJXAQDMKSA-N
4961	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Kvernmo T (2008)	18691132	174662	261	Ropinirole	Ropinirolum|Ropinirole|Ropinirol	apo-ropinirole|phl-ropinirole|	DRUGBANK	DB00268	C16H24N2O	small molecule	N04BC04	91374-21-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UHSKFQJFRQCDBE-UHFFFAOYSA-N
4973	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Peterson BZ (2006)	16675661	174772	263	Isradipine	Isradipino|Dynacirc|Isradipinum	isradipine	DRUGBANK	DB00270	C19H21N3O5	small molecule	C08CA03	75695-93-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HMJIYCCIJYRONP-UHFFFAOYSA-N
5086	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Muroi Y (2009)	19088384	174879	274	Lidocaine	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|alpha-diethylamino-2,6-dimethylacetanilide|Lignocaine|2-(Diethylamino)-2',6'-acetoxylidide|-diethylamino-2,6-dimethylacetanilide	scar zone burn gel|sting relie	DRUGBANK	DB00281	C14H22N2O	small molecule	C05AD01|N01BB52|D04AB01|C01BB01|N01BB02|R02AD02|S01HA07|S02DA01	137-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NNJVILVZKWQKPM-UHFFFAOYSA-N
5087	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Karoly R (2010)	20585544	174878	274	Lidocaine	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|alpha-diethylamino-2,6-dimethylacetanilide|Lignocaine|2-(Diethylamino)-2',6'-acetoxylidide|-diethylamino-2,6-dimethylacetanilide	scar zone burn gel|sting relie	DRUGBANK	DB00281	C14H22N2O	small molecule	C05AD01|N01BB52|D04AB01|C01BB01|N01BB02|R02AD02|S01HA07|S02DA01	137-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NNJVILVZKWQKPM-UHFFFAOYSA-N
5088	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Sheets PL (2007)	17430993	174880	274	Lidocaine	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|alpha-diethylamino-2,6-dimethylacetanilide|Lignocaine|2-(Diethylamino)-2',6'-acetoxylidide|-diethylamino-2,6-dimethylacetanilide	scar zone burn gel|sting relie	DRUGBANK	DB00281	C14H22N2O	small molecule	C05AD01|N01BB52|D04AB01|C01BB01|N01BB02|R02AD02|S01HA07|S02DA01	137-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NNJVILVZKWQKPM-UHFFFAOYSA-N
5089	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Sakaguchi M (2006)	16551906	174881	274	Lidocaine	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|alpha-diethylamino-2,6-dimethylacetanilide|Lignocaine|2-(Diethylamino)-2',6'-acetoxylidide|-diethylamino-2,6-dimethylacetanilide	scar zone burn gel|sting relie	DRUGBANK	DB00281	C14H22N2O	small molecule	C05AD01|N01BB52|D04AB01|C01BB01|N01BB02|R02AD02|S01HA07|S02DA01	137-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NNJVILVZKWQKPM-UHFFFAOYSA-N
5090	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Muroi Y (2009)	19088384	174879	274	Lidocaine	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|alpha-diethylamino-2,6-dimethylacetanilide|Lignocaine|2-(Diethylamino)-2',6'-acetoxylidide|-diethylamino-2,6-dimethylacetanilide	scar zone burn gel|sting relie	DRUGBANK	DB00281	C14H22N2O	small molecule	C05AD01|N01BB52|D04AB01|C01BB01|N01BB02|R02AD02|S01HA07|S02DA01	137-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NNJVILVZKWQKPM-UHFFFAOYSA-N
5091	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Karoly R (2010)	20585544	174878	274	Lidocaine	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|alpha-diethylamino-2,6-dimethylacetanilide|Lignocaine|2-(Diethylamino)-2',6'-acetoxylidide|-diethylamino-2,6-dimethylacetanilide	scar zone burn gel|sting relie	DRUGBANK	DB00281	C14H22N2O	small molecule	C05AD01|N01BB52|D04AB01|C01BB01|N01BB02|R02AD02|S01HA07|S02DA01	137-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NNJVILVZKWQKPM-UHFFFAOYSA-N
5092	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Ekberg J (2006)	17077153	174882	274	Lidocaine	2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|alpha-diethylamino-2,6-dimethylacetanilide|Lignocaine|2-(Diethylamino)-2',6'-acetoxylidide|-diethylamino-2,6-dimethylacetanilide	scar zone burn gel|sting relie	DRUGBANK	DB00281	C14H22N2O	small molecule	C05AD01|N01BB52|D04AB01|C01BB01|N01BB02|R02AD02|S01HA07|S02DA01	137-58-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NNJVILVZKWQKPM-UHFFFAOYSA-N
5192	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	blocker	target	Ludolph AG (2010)	20423340	174993	282	Atomoxetine	Tomoxetine|Tomoxetinum|(-)-Tomoxetine|Tomoxetina	riva-atomoxetine|strattera|pms	DRUGBANK	DB00289	C17H21NO	small molecule	N06BA09	83015-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VHGCDTVCOLNTBX-QGZVFWFLSA-N
5239	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	289	Ropivacaine	Ropivacainum|(S)-()-1-propyl-2',6'-pipecoloxylidide|L-N-n-propylpipecolic acid-2,6-xylidide|Ropivacaine|Ropivacaina|(S)-ropivacaine	ropivacaine hydrochloride|ropi	DRUGBANK	DB00296	C17H26N2O	small molecule	N01BB09	84057-95-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKMNUMMKYBVTFN-GGYSOQFKNA-N
5240	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	289	Ropivacaine	Ropivacainum|(S)-()-1-propyl-2',6'-pipecoloxylidide|L-N-n-propylpipecolic acid-2,6-xylidide|Ropivacaine|Ropivacaina|(S)-ropivacaine	ropivacaine hydrochloride|ropi	DRUGBANK	DB00296	C17H26N2O	small molecule	N01BB09	84057-95-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKMNUMMKYBVTFN-GGYSOQFKNA-N
5241	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Liu BG (2000)	10781449	175035	289	Ropivacaine	Ropivacainum|(S)-()-1-propyl-2',6'-pipecoloxylidide|L-N-n-propylpipecolic acid-2,6-xylidide|Ropivacaine|Ropivacaina|(S)-ropivacaine	ropivacaine hydrochloride|ropi	DRUGBANK	DB00296	C17H26N2O	small molecule	N01BB09	84057-95-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKMNUMMKYBVTFN-GGYSOQFKNA-N
5245	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Sheets MF (2010)	20685573	175038	290	Bupivacaine	1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide|dl-1-Butyl-2',6'-pipecoloxylidide|(RS)-bupivacaine|Bupivacainum|1-Butyl-2',6'-pipecoloxylidide|racemic bupivacaine|()-bupivacaine|DL-Bupivacaine|Bupivacaina	bupivacaine hydrochloride inje	DRUGBANK	DB00297	C18H28N2O	small molecule	N01BB01|N01BB51	38396-39-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEBVLXFERQHONN-UHFFFAOYSA-N
5246	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	290	Bupivacaine	1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide|dl-1-Butyl-2',6'-pipecoloxylidide|(RS)-bupivacaine|Bupivacainum|1-Butyl-2',6'-pipecoloxylidide|racemic bupivacaine|()-bupivacaine|DL-Bupivacaine|Bupivacaina	bupivacaine hydrochloride inje	DRUGBANK	DB00297	C18H28N2O	small molecule	N01BB01|N01BB51	38396-39-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEBVLXFERQHONN-UHFFFAOYSA-N
5247	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	290	Bupivacaine	1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide|dl-1-Butyl-2',6'-pipecoloxylidide|(RS)-bupivacaine|Bupivacainum|1-Butyl-2',6'-pipecoloxylidide|racemic bupivacaine|()-bupivacaine|DL-Bupivacaine|Bupivacaina	bupivacaine hydrochloride inje	DRUGBANK	DB00297	C18H28N2O	small molecule	N01BB01|N01BB51	38396-39-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEBVLXFERQHONN-UHFFFAOYSA-N
5296	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	299	Talbutal	(RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione|sec-Butyl allyl barbituric acid|5-allyl-5-sec-butylbarbituric acid|Talbutale|Talbutalum|Lotusate	-	DRUGBANK	DB00306	C11H16N2O3	small molecule	N05CA07	115-44-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BJVVMKUXKQHWJK-UHFFFAOYSA-N
5297	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	299	Talbutal	(RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione|sec-Butyl allyl barbituric acid|5-allyl-5-sec-butylbarbituric acid|Talbutale|Talbutalum|Lotusate	-	DRUGBANK	DB00306	C11H16N2O3	small molecule	N05CA07	115-44-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BJVVMKUXKQHWJK-UHFFFAOYSA-N
5397	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	305	Pentobarbital	5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione|Pentobarbital|5-ethyl-5-(sec-pentyl)barbituric acid|Pentobarbitone|Nembutal|5-ethyl-5-(1-methylbutyl)barbituric acid	nembutal sodium inj 50mg/ml|no	DRUGBANK	DB00312	C11H18N2O3	small molecule	N05CA01	76-74-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WEXRUCMBJFQVBZ-UHFFFAOYSA-N
5398	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	305	Pentobarbital	5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione|Pentobarbital|5-ethyl-5-(sec-pentyl)barbituric acid|Pentobarbitone|Nembutal|5-ethyl-5-(1-methylbutyl)barbituric acid	nembutal sodium inj 50mg/ml|no	DRUGBANK	DB00312	C11H18N2O3	small molecule	N05CA01	76-74-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WEXRUCMBJFQVBZ-UHFFFAOYSA-N
5412	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Daniell LC (1994)	7862741	175103	305	Pentobarbital	5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione|Pentobarbital|5-ethyl-5-(sec-pentyl)barbituric acid|Pentobarbitone|Nembutal|5-ethyl-5-(1-methylbutyl)barbituric acid	nembutal sodium inj 50mg/ml|no	DRUGBANK	DB00312	C11H18N2O3	small molecule	N05CA01	76-74-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WEXRUCMBJFQVBZ-UHFFFAOYSA-N
5432	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	unknown	target	Farber NB (2002)	12192617	175117	306	Valproic Acid	2-Propylpentanoic Acid|4-heptanecarboxylic acid|di-n-propylacetic acid|2-Propylvaleric Acid|Di-n-propylessigsure|acide valproque|n-DPA|acidum valproicum|Valproate|Valproinsure|Dipropylacetic acid|2-propyl-pentanoic acid|2-n-propyl-n-valeric acid|DPA|VPA|cido valproico	dom-valproic acid syrup|divalp	DRUGBANK	DB00313	C8H16O2	small molecule	N03AG01	99-66-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NIJJYAXOARWZEE-UHFFFAOYSA-N
5444	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	unknown	target	Farber NB (2002)	12192617	175117	306	Valproic Acid	2-Propylpentanoic Acid|4-heptanecarboxylic acid|di-n-propylacetic acid|2-Propylvaleric Acid|Di-n-propylessigsure|acide valproque|n-DPA|acidum valproicum|Valproate|Valproinsure|Dipropylacetic acid|2-propyl-pentanoic acid|2-n-propyl-n-valeric acid|DPA|VPA|cido valproico	dom-valproic acid syrup|divalp	DRUGBANK	DB00313	C8H16O2	small molecule	N03AG01	99-66-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NIJJYAXOARWZEE-UHFFFAOYSA-N
5481	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Nicholson RI (2001)	11566608	175152	310	Gefitinib	N-(3-chloro-4-Fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine|Gefitinib|ZD 1839|4-(3'-chloro-4'-Fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline|Iressa	iressa	DRUGBANK	DB00317	C22H24ClFN4O3	small molecule	L01XE02	184475-35-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XGALLCVXEZPNRQ-UHFFFAOYSA-N
5482	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Albanell J (2001)	11522647	175151	310	Gefitinib	N-(3-chloro-4-Fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine|Gefitinib|ZD 1839|4-(3'-chloro-4'-Fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline|Iressa	iressa	DRUGBANK	DB00317	C22H24ClFN4O3	small molecule	L01XE02	184475-35-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XGALLCVXEZPNRQ-UHFFFAOYSA-N
5483	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Arteaga CL (2001)	11673690	175150	310	Gefitinib	N-(3-chloro-4-Fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine|Gefitinib|ZD 1839|4-(3'-chloro-4'-Fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline|Iressa	iressa	DRUGBANK	DB00317	C22H24ClFN4O3	small molecule	L01XE02	184475-35-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XGALLCVXEZPNRQ-UHFFFAOYSA-N
5484	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	310	Gefitinib	N-(3-chloro-4-Fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine|Gefitinib|ZD 1839|4-(3'-chloro-4'-Fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline|Iressa	iressa	DRUGBANK	DB00317	C22H24ClFN4O3	small molecule	L01XE02	184475-35-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XGALLCVXEZPNRQ-UHFFFAOYSA-N
5485	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Ciardiello F (2000)	10815932	175148	310	Gefitinib	N-(3-chloro-4-Fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine|Gefitinib|ZD 1839|4-(3'-chloro-4'-Fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline|Iressa	iressa	DRUGBANK	DB00317	C22H24ClFN4O3	small molecule	L01XE02	184475-35-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XGALLCVXEZPNRQ-UHFFFAOYSA-N
5486	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Moasser MM (2001)	11585753	175149	310	Gefitinib	N-(3-chloro-4-Fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine|Gefitinib|ZD 1839|4-(3'-chloro-4'-Fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline|Iressa	iressa	DRUGBANK	DB00317	C22H24ClFN4O3	small molecule	L01XE02	184475-35-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XGALLCVXEZPNRQ-UHFFFAOYSA-N
5660	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Shahid M (2009)	18308814	175311	326	Olanzapine	Olanzapinum|2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine|Olanzapin|Olanzapine|Zyprexa|Olanzapina	olanzapine and fluoxetine|sand	DRUGBANK	DB00334	C17H20N4S	small molecule	N05AH03	132539-06-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KVWDHTXUZHCGIO-UHFFFAOYSA-N
5661	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Fernandez J (2005)	15771415	175310	326	Olanzapine	Olanzapinum|2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine|Olanzapin|Olanzapine|Zyprexa|Olanzapina	olanzapine and fluoxetine|sand	DRUGBANK	DB00334	C17H20N4S	small molecule	N05AH03	132539-06-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KVWDHTXUZHCGIO-UHFFFAOYSA-N
5689	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Nasrallah HA (2008)	17848919	174616	326	Olanzapine	Olanzapinum|2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine|Olanzapin|Olanzapine|Zyprexa|Olanzapina	olanzapine and fluoxetine|sand	DRUGBANK	DB00334	C17H20N4S	small molecule	N05AH03	132539-06-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KVWDHTXUZHCGIO-UHFFFAOYSA-N
5690	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Bymaster FP (1999)	10227113	175304	326	Olanzapine	Olanzapinum|2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine|Olanzapin|Olanzapine|Zyprexa|Olanzapina	olanzapine and fluoxetine|sand	DRUGBANK	DB00334	C17H20N4S	small molecule	N05AH03	132539-06-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KVWDHTXUZHCGIO-UHFFFAOYSA-N
5719	108833	2559	-	GABRA6	-	9606	Homo sapiens	unknown	target	Bymaster FP (1996)	8822531	175320	326	Olanzapine	Olanzapinum|2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine|Olanzapin|Olanzapine|Zyprexa|Olanzapina	olanzapine and fluoxetine|sand	DRUGBANK	DB00334	C17H20N4S	small molecule	N05AH03	132539-06-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KVWDHTXUZHCGIO-UHFFFAOYSA-N
5725	108835	2561	-	GABRB2	-	9606	Homo sapiens	unknown	target	Bymaster FP (1996)	8822531	175320	326	Olanzapine	Olanzapinum|2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine|Olanzapin|Olanzapine|Zyprexa|Olanzapina	olanzapine and fluoxetine|sand	DRUGBANK	DB00334	C17H20N4S	small molecule	N05AH03	132539-06-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KVWDHTXUZHCGIO-UHFFFAOYSA-N
5849	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Moehler H (2002)	11752090	174537	341	Clobazam	Clobazam|1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine|Clobazamum|7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione	onfi|clobazam-10|apo-clobazam 	DRUGBANK	DB00349	C16H13ClN2O2	small molecule	N05BA09	22316-47-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CXOXHMZGEKVPMT-UHFFFAOYSA-N
5850	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	341	Clobazam	Clobazam|1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine|Clobazamum|7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione	onfi|clobazam-10|apo-clobazam 	DRUGBANK	DB00349	C16H13ClN2O2	small molecule	N05BA09	22316-47-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CXOXHMZGEKVPMT-UHFFFAOYSA-N
5861	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Moehler H (2002)	11752090	174537	341	Clobazam	Clobazam|1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine|Clobazamum|7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione	onfi|clobazam-10|apo-clobazam 	DRUGBANK	DB00349	C16H13ClN2O2	small molecule	N05BA09	22316-47-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CXOXHMZGEKVPMT-UHFFFAOYSA-N
5862	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	341	Clobazam	Clobazam|1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine|Clobazamum|7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione	onfi|clobazam-10|apo-clobazam 	DRUGBANK	DB00349	C16H13ClN2O2	small molecule	N05BA09	22316-47-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CXOXHMZGEKVPMT-UHFFFAOYSA-N
6014	108557	2266	PRO2061	FGG	-	9606	Homo sapiens	antagonist	target	Terao N (1980)	6892775	175526	356	Sucralfate	Sucralfate|Sucralfatum|Sucralfato|Hexadeca--hydroxytetracosahydroxy[8-[1,3,4,6-tetra-O-sulfo--Dfructofuranosyl--D-glucopyranoside tetrakis(hydrogen sulfato)8-)]]hexadecaaluminum|Sucralfat	sulcrate suspension plus|caraf	DRUGBANK	DB00364	C11H28Al8O51S8	small molecule	A02BX02	54182-58-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MNQYNQBOVCBZIQ-JQOFMKNESA-A
6015	108534	2243	-	FGA	Fib2	9606	Homo sapiens	antagonist	target	Terao N (1980)	6892775	175526	356	Sucralfate	Sucralfate|Sucralfatum|Sucralfato|Hexadeca--hydroxytetracosahydroxy[8-[1,3,4,6-tetra-O-sulfo--Dfructofuranosyl--D-glucopyranoside tetrakis(hydrogen sulfato)8-)]]hexadecaaluminum|Sucralfat	sulcrate suspension plus|caraf	DRUGBANK	DB00364	C11H28Al8O51S8	small molecule	A02BX02	54182-58-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MNQYNQBOVCBZIQ-JQOFMKNESA-A
6138	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	binder	target	de Boer T (1995)	8930006	175620	362	Mirtazapine	Mirtazapinum|Mirtazapin|Mepirzapine|Mirtazapina|1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine|6-Azamianserin|Mirtazapine	dom-mirtazapine|ratio-mirtazap	DRUGBANK	DB00370	C17H19N3	small molecule	N06AX11	85650-52-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RONZAEMNMFQXRA-UHFFFAOYSA-N
6139	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	binder	target	Fernandez J (2005)	15771415	175310	362	Mirtazapine	Mirtazapinum|Mirtazapin|Mepirzapine|Mirtazapina|1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine|6-Azamianserin|Mirtazapine	dom-mirtazapine|ratio-mirtazap	DRUGBANK	DB00370	C17H19N3	small molecule	N06AX11	85650-52-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RONZAEMNMFQXRA-UHFFFAOYSA-N
6140	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	binder	target	de Boer TH (1988)	3419539	175611	362	Mirtazapine	Mirtazapinum|Mirtazapin|Mepirzapine|Mirtazapina|1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine|6-Azamianserin|Mirtazapine	dom-mirtazapine|ratio-mirtazap	DRUGBANK	DB00370	C17H19N3	small molecule	N06AX11	85650-52-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RONZAEMNMFQXRA-UHFFFAOYSA-N
6187	108833	2559	-	GABRA6	-	9606	Homo sapiens	agonist	target	Gonzalez LA (2009)	19244096	175633	363	Meprobamate	Meprobamat|Meprobamatum|Miltown|Equanil|Meprobamato|Meprobamic acid	282 mep tab|apo meprobamate ta	DRUGBANK	DB00371	C9H18N2O4	small molecule	N05CX01|N05BC01|N05BC51	57-53-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NPPQSCRMBWNHMW-UHFFFAOYSA-N
6188	108833	2559	-	GABRA6	-	9606	Homo sapiens	agonist	target	Rho JM (1997)	9067327	175634	363	Meprobamate	Meprobamat|Meprobamatum|Miltown|Equanil|Meprobamato|Meprobamic acid	282 mep tab|apo meprobamate ta	DRUGBANK	DB00371	C9H18N2O4	small molecule	N05CX01|N05BC01|N05BC51	57-53-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NPPQSCRMBWNHMW-UHFFFAOYSA-N
6277	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Peterson BZ (2006)	16675661	174772	373	Amlodipine	3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate|Amlodipine|Amlodipine free base|3-Ethyl 5-methylester, ()-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate|Amlodipinum|Amlodipino|(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate	amlodipine and benazepril hydr	DRUGBANK	DB00381	C20H25ClN2O5	small molecule	C08CA01|C09BX01|C08GA02|C10BX07|C09XA53|C09BB03|C10BX03|C09BB07|C09XA54|C09DB02|C09DB01|C09DB07|C09DB06|C09DB05|C09DB04|C09DX01|C09BB04|C09DX03|C10BX09|C10BX11	88150-42-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HTIQEAQVCYTUBX-UHFFFAOYSA-N
6420	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Peterson BZ (2006)	16675661	174772	385	Nimodipine	Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate|BAY e 9736|2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester|Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate|Nimodipino|Periplum|Nimodipinum|Nimodipine|Nimotop	nymalize|nimotop iv 0.2mg/ml|n	DRUGBANK	DB00393	C21H26N2O7	small molecule	C08CA06	66085-59-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
6421	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Kim JH (2009)	19844625	175775	385	Nimodipine	Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate|BAY e 9736|2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester|Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate|Nimodipino|Periplum|Nimodipinum|Nimodipine|Nimotop	nymalize|nimotop iv 0.2mg/ml|n	DRUGBANK	DB00393	C21H26N2O7	small molecule	C08CA06	66085-59-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
6422	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Dong CJ (2010)	20335610	175774	385	Nimodipine	Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate|BAY e 9736|2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester|Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate|Nimodipino|Periplum|Nimodipinum|Nimodipine|Nimotop	nymalize|nimotop iv 0.2mg/ml|n	DRUGBANK	DB00393	C21H26N2O7	small molecule	C08CA06	66085-59-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
6423	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Kumar R (2010)	20661350	175773	385	Nimodipine	Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate|BAY e 9736|2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester|Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate|Nimodipino|Periplum|Nimodipinum|Nimodipine|Nimotop	nymalize|nimotop iv 0.2mg/ml|n	DRUGBANK	DB00393	C21H26N2O7	small molecule	C08CA06	66085-59-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
6424	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Weant KA (2010)	20334460	175772	385	Nimodipine	Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate|BAY e 9736|2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester|Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate|Nimodipino|Periplum|Nimodipinum|Nimodipine|Nimotop	nymalize|nimotop iv 0.2mg/ml|n	DRUGBANK	DB00393	C21H26N2O7	small molecule	C08CA06	66085-59-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
6425	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Keyrouz SG (2007)	17705883	175771	385	Nimodipine	Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate|BAY e 9736|2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester|Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate|Nimodipino|Periplum|Nimodipinum|Nimodipine|Nimotop	nymalize|nimotop iv 0.2mg/ml|n	DRUGBANK	DB00393	C21H26N2O7	small molecule	C08CA06	66085-59-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UIAGMCDKSXEBJQ-UHFFFAOYSA-N
6496	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	antagonist	target	Adnane L (2006)	16757355	175807	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6497	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	antagonist	target	Rini BI (2006)	16503817	175824	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6498	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	antagonist	target	Veronese ML (2006)	16446323	175823	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6499	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	antagonist	target	Lacouture ME (2006)	16824050	175822	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6500	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	antagonist	target	Schoeffski P (2006)	16418310	175821	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6501	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Lu X (2010)	20812347	175817	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6502	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6503	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Kim S (2007)	17575107	175827	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6504	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Eisen T (2006)	16880785	175826	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6505	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Haluska FG (2006)	16901402	175825	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6506	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Flaherty KT (2006)	16609060	175828	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6507	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Liu L (2006)	17178882	175830	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6508	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Guida T (2007)	17545544	175831	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6509	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Lierman E (2007)	17229632	175832	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6510	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Cascone T (2007)	17272980	175818	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6511	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Koch CA (2006)	17102120	175829	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6515	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	inhibitor	target	Carlomagno F (2006)	16507829	175814	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6516	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	inhibitor	target	Wilhelm S (2006)	17016424	175812	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6517	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	inhibitor	target	Wilhelm SM (2004)	15466206	175813	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6531	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Peterson BZ (2006)	16675661	174772	393	Nisoldipine	isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate|Nisoldipina|Nisoldipine|Nisoldipin|Nisoldipinum|Nisoldipino|Sular	nisoldipine|sular	DRUGBANK	DB00401	C20H24N2O6	small molecule	C08CA07	63675-72-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VKQFCGNPDRICFG-UHFFFAOYSA-N
6558	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Verster JC (2004)	14978513	175867	396	Alprazolam	Alprazolam|8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine|Xanax	nu-alpraz tab 0.5mg|alprazolam	DRUGBANK	DB00404	C17H13ClN4	small molecule	N05BA12	28981-97-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VREFGVBLTWBCJP-UHFFFAOYSA-N
6559	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	396	Alprazolam	Alprazolam|8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine|Xanax	nu-alpraz tab 0.5mg|alprazolam	DRUGBANK	DB00404	C17H13ClN4	small molecule	N05BA12	28981-97-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VREFGVBLTWBCJP-UHFFFAOYSA-N
6570	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Verster JC (2004)	14978513	175867	396	Alprazolam	Alprazolam|8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine|Xanax	nu-alpraz tab 0.5mg|alprazolam	DRUGBANK	DB00404	C17H13ClN4	small molecule	N05BA12	28981-97-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VREFGVBLTWBCJP-UHFFFAOYSA-N
6571	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	396	Alprazolam	Alprazolam|8-Chloro-1-methyl-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine|Xanax	nu-alpraz tab 0.5mg|alprazolam	DRUGBANK	DB00404	C17H13ClN4	small molecule	N05BA12	28981-97-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VREFGVBLTWBCJP-UHFFFAOYSA-N
6653	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	unknown	target	Lam YW (2000)	10641988	174664	405	Pramipexole	(S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine|Pramipexol|Pramipexole|2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-|(-)-Pramipexole|Pramipexolum	auro-pramipexole|mylan-pramipe	DRUGBANK	DB00413	C10H17N3S	small molecule	N04BC05	104632-26-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FASDKYOPVNHBLU-ZETCQYMHSA-N
6689	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	410	Secobarbital	5-(1-Methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|Secobarbitone|(+-)-Secobarbital|Secobarbitalum|5-allyl-5-(1-methylbutyl)barbituric acid|Seconal|5-Allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|Quinalbarbitone|5-Allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione|()-secobarbital	seconal sodium pulvule 240 0.1	DRUGBANK	DB00418	C12H18N2O3	small molecule	N05CA06	76-73-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KQPKPCNLIDLUMF-UHFFFAOYSA-N
6690	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	410	Secobarbital	5-(1-Methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|Secobarbitone|(+-)-Secobarbital|Secobarbitalum|5-allyl-5-(1-methylbutyl)barbituric acid|Seconal|5-Allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|Quinalbarbitone|5-Allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione|()-secobarbital	seconal sodium pulvule 240 0.1	DRUGBANK	DB00418	C12H18N2O3	small molecule	N05CA06	76-73-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KQPKPCNLIDLUMF-UHFFFAOYSA-N
6704	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Daniell LC (1994)	7862741	175103	410	Secobarbital	5-(1-Methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|Secobarbitone|(+-)-Secobarbital|Secobarbitalum|5-allyl-5-(1-methylbutyl)barbituric acid|Seconal|5-Allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|Quinalbarbitone|5-Allyl-5-(1-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione|()-secobarbital	seconal sodium pulvule 240 0.1	DRUGBANK	DB00418	C12H18N2O3	small molecule	N05CA06	76-73-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KQPKPCNLIDLUMF-UHFFFAOYSA-N
6788	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	unknown	target	Melander A (1977)	872489	175956	413	Spironolactone	Spironolactone|Spironolactonum|Spironolattone|Espironolactona	apo-spirozide tab|ntp-spironol	DRUGBANK	DB00421	C24H32O4S	small molecule	C03DA01	52-01-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LXMSZDCAJNLERA-ZHYRCANASA-N
6789	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	unknown	target	Sorrentino R (2000)	10942165	175955	413	Spironolactone	Spironolactone|Spironolactonum|Spironolattone|Espironolactona	apo-spirozide tab|ntp-spironol	DRUGBANK	DB00421	C24H32O4S	small molecule	C03DA01	52-01-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LXMSZDCAJNLERA-ZHYRCANASA-N
7041	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Yamakura T (2000)	10735801	176162	446	Pethidine	Meperidine|Petidina|Pethidinum|Sauteralgyl|Spasmodolin|Petydyna|Spasmedal|Pthidine|Isonipecane|Pethidin|Pethidine dbl	demerol 50 mg/ml   (multiple d	DRUGBANK	DB00454	C15H21NO2	small molecule	N02AB02|N02AB52|N02AG03|N02AB72	57-42-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XADCESSVHJOZHK-UHFFFAOYSA-N
7095	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	binder	target	Toll L (1998)	9686407	176206	450	Imipramine	N-(-dimethylaminopropyl)iminodibenzyl|Imipraminum|Antideprin|3-(5H-DIBENZO[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine|10,11-dihydro-N,N-Dimethyl-5H-dibenz[b,F]azepine-5-propanamine|Irmin|Imipramine|Imizine|5-[3-(dimethylamino)Propyl]-10,11-dihydro-5H-dibenz[b,F]azepine|Melipramine|N-(gamma-Dimethylaminopropyl)iminodibenzyl|Imipramin	tofranil|imipramine tab 25mg|i	DRUGBANK	DB00458	C19H24N2	small molecule	N06AA02	50-49-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCGWQEUPMDMJNV-UHFFFAOYSA-N
7183	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	455	Metharbital	Metharbital|Metharbitalum|Metarbital	-	DRUGBANK	DB00463	C9H14N2O3	small molecule	N03AA30	50-11-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FWJKNZONDWOGMI-UHFFFAOYSA-N
7184	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	455	Metharbital	Metharbital|Metharbitalum|Metarbital	-	DRUGBANK	DB00463	C9H14N2O3	small molecule	N03AA30	50-11-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FWJKNZONDWOGMI-UHFFFAOYSA-N
7259	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	465	Hexylcaine	Cyclaine|Hexylcaine|Hexilcaina|Hexylcainum	-	DRUGBANK	DB00473	C16H23NO2	small molecule	-	532-77-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DKLKMKYDWHYZTD-UHFFFAOYSA-N
7260	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	465	Hexylcaine	Cyclaine|Hexylcaine|Hexilcaina|Hexylcainum	-	DRUGBANK	DB00473	C16H23NO2	small molecule	-	532-77-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DKLKMKYDWHYZTD-UHFFFAOYSA-N
7269	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Skerritt JH (1983)	6135616	176313	467	Chlordiazepoxide	Chloradiazepoxide|Methaminodiazepoxide|Risolid|Silibrin|Clopoxide|Tropium|Libritabs|CDP|7-chloro-2-Methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide|Helogaphen|Multum|Chlordiazepoxide base|Chlordiazepoxidum	chlordiazepoxide hydrochloride	DRUGBANK	DB00475	C16H14ClN3O	small molecule	N05BA02	58-25-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ANTSCNMPPGJYLG-UHFFFAOYSA-N
7275	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Skerritt JH (1983)	6135616	176313	467	Chlordiazepoxide	Chloradiazepoxide|Methaminodiazepoxide|Risolid|Silibrin|Clopoxide|Tropium|Libritabs|CDP|7-chloro-2-Methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide|Helogaphen|Multum|Chlordiazepoxide base|Chlordiazepoxidum	chlordiazepoxide hydrochloride	DRUGBANK	DB00475	C16H14ClN3O	small molecule	N05BA02	58-25-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ANTSCNMPPGJYLG-UHFFFAOYSA-N
7326	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	unknown	target	Seeman P (1993)	8104554	176336	469	Chlorpromazine	Chlorpromazine|Chloropromazine|Largactil|CPZ|N-(3-Dimethylaminopropyl)-3-chlorophenothiazine|Aminazine|Chlorpromados|Chlorpromazinum|Clorpromazina|Chlorderazin|3-(2-chloro-10H-Phenothiazin-10-yl)-N,N-dimethyl-1-propanamine|Contomin|3-(2-Chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine|Thorazine	chlorpromanyl 20 syr|chlorprom	DRUGBANK	DB00477	C17H19ClN2S	small molecule	N05AA01	50-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
7738	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Louro SR (1998)	9742684	176670	517	Cinchocaine	alpha-Butyloxycinchoninic acid diethylethylenediamide|Cincocainio|N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide|2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide|Dibucaine|CINCHOCAINE|2-Butoxy-N-(alpha-diethylaminoethyl)cinchoninamide|2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide|2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide|2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide|Cinchocainum|2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide|Dibucaine base|2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide|alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine	proctol ointment|proctosone su	DRUGBANK	DB00527	C20H29N3O2	small molecule	S01HA06|D04AB02|C05AD04|N01BB06|S02DA04	85-79-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PUFQVTATUTYEAL-UHFFFAOYSA-N
7739	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	517	Cinchocaine	alpha-Butyloxycinchoninic acid diethylethylenediamide|Cincocainio|N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide|2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide|Dibucaine|CINCHOCAINE|2-Butoxy-N-(alpha-diethylaminoethyl)cinchoninamide|2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide|2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide|2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide|Cinchocainum|2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide|Dibucaine base|2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide|alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine	proctol ointment|proctosone su	DRUGBANK	DB00527	C20H29N3O2	small molecule	S01HA06|D04AB02|C05AD04|N01BB06|S02DA04	85-79-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PUFQVTATUTYEAL-UHFFFAOYSA-N
7740	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Ryan SE (1996)	8798723	176671	517	Cinchocaine	alpha-Butyloxycinchoninic acid diethylethylenediamide|Cincocainio|N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide|2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide|Dibucaine|CINCHOCAINE|2-Butoxy-N-(alpha-diethylaminoethyl)cinchoninamide|2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide|2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide|2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide|Cinchocainum|2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide|Dibucaine base|2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide|alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine	proctol ointment|proctosone su	DRUGBANK	DB00527	C20H29N3O2	small molecule	S01HA06|D04AB02|C05AD04|N01BB06|S02DA04	85-79-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PUFQVTATUTYEAL-UHFFFAOYSA-N
7741	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	517	Cinchocaine	alpha-Butyloxycinchoninic acid diethylethylenediamide|Cincocainio|N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide|2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide|Dibucaine|CINCHOCAINE|2-Butoxy-N-(alpha-diethylaminoethyl)cinchoninamide|2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide|2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide|2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide|Cinchocainum|2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide|Dibucaine base|2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide|alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine	proctol ointment|proctosone su	DRUGBANK	DB00527	C20H29N3O2	small molecule	S01HA06|D04AB02|C05AD04|N01BB06|S02DA04	85-79-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PUFQVTATUTYEAL-UHFFFAOYSA-N
7762	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Bulgaru AM (2003)	12820772	176686	520	Erlotinib	OSI-774|[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine|Erlotinib	pms-erlotinib|tarceva|teva-erl	DRUGBANK	DB00530	C22H23N3O4	small molecule	L01XE03	183321-74-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AAKJLRGGTJKAMG-UHFFFAOYSA-N
7763	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Kim TE (2002)	12498017	176687	520	Erlotinib	OSI-774|[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine|Erlotinib	pms-erlotinib|tarceva|teva-erl	DRUGBANK	DB00530	C22H23N3O4	small molecule	L01XE03	183321-74-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AAKJLRGGTJKAMG-UHFFFAOYSA-N
7764	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Akita RW (2003)	12840797	176684	520	Erlotinib	OSI-774|[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine|Erlotinib	pms-erlotinib|tarceva|teva-erl	DRUGBANK	DB00530	C22H23N3O4	small molecule	L01XE03	183321-74-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AAKJLRGGTJKAMG-UHFFFAOYSA-N
7765	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Laird AD (2003)	12517254	176685	520	Erlotinib	OSI-774|[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine|Erlotinib	pms-erlotinib|tarceva|teva-erl	DRUGBANK	DB00530	C22H23N3O4	small molecule	L01XE03	183321-74-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AAKJLRGGTJKAMG-UHFFFAOYSA-N
7766	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Delbaldo C (2003)	12814826	176683	520	Erlotinib	OSI-774|[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine|Erlotinib	pms-erlotinib|tarceva|teva-erl	DRUGBANK	DB00530	C22H23N3O4	small molecule	L01XE03	183321-74-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AAKJLRGGTJKAMG-UHFFFAOYSA-N
7767	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	520	Erlotinib	OSI-774|[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine|Erlotinib	pms-erlotinib|tarceva|teva-erl	DRUGBANK	DB00530	C22H23N3O4	small molecule	L01XE03	183321-74-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AAKJLRGGTJKAMG-UHFFFAOYSA-N
7899	108833	2559	-	GABRA6	-	9606	Homo sapiens	binder	target	Wei HB (1990)	1966571	176782	533	Amoxapine	2-Chloro-11-(1-piperazinyl)dibenz(b,F)(1,4)oxazepine|Amoxapina|Amoxapin|Amoxepine|Desmethylloxapin|Amoxapinum	asendin tab 25mg|asendin - tab	DRUGBANK	DB00543	C17H16ClN3O	small molecule	N06AA17	14028-44-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QWGDMFLQWFTERH-UHFFFAOYSA-N
7905	108835	2561	-	GABRB2	-	9606	Homo sapiens	binder	target	Wei HB (1990)	1966571	176782	533	Amoxapine	2-Chloro-11-(1-piperazinyl)dibenz(b,F)(1,4)oxazepine|Amoxapina|Amoxapin|Amoxepine|Desmethylloxapin|Amoxapinum	asendin tab 25mg|asendin - tab	DRUGBANK	DB00543	C17H16ClN3O	small molecule	N06AA17	14028-44-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QWGDMFLQWFTERH-UHFFFAOYSA-N
7942	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Lahti RA (1983)	6320036	176808	536	Adinazolam	Adinazolamum|8-Chloro-1-((dimethylamino)methyl)-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine	-	DRUGBANK	DB00546	C19H18ClN5	small molecule	N05BA07	37115-32-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GJSLOMWRLALDCT-UHFFFAOYSA-N
7943	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Sethy VH (1984)	6148400	176809	536	Adinazolam	Adinazolamum|8-Chloro-1-((dimethylamino)methyl)-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepine	-	DRUGBANK	DB00546	C19H18ClN5	small molecule	N05BA07	37115-32-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GJSLOMWRLALDCT-UHFFFAOYSA-N
8084	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Singh BN (1986)	3530295	176934	558	Cinnarizine	1-Cinnamyl-4-(diphenylmethyl)piperazine|Cinnarizin|1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine|Cinnarizine|Cinarizina|1-Benzhydryl-4-cinnamylpiperazin|Cinnarizinum	-	DRUGBANK	DB00568	C26H28N2	small molecule	N07CA02|N07CA52	298-57-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DERZBLKQOCDDDZ-JLHYYAGUSA-N
8085	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Cohen CJ (1992)	1281221	174770	558	Cinnarizine	1-Cinnamyl-4-(diphenylmethyl)piperazine|Cinnarizin|1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine|Cinnarizine|Cinarizina|1-Benzhydryl-4-cinnamylpiperazin|Cinnarizinum	-	DRUGBANK	DB00568	C26H28N2	small molecule	N07CA02|N07CA52	298-57-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DERZBLKQOCDDDZ-JLHYYAGUSA-N
8101	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	binder	target	Nasu R (2000)	11180191	176779	558	Cinnarizine	1-Cinnamyl-4-(diphenylmethyl)piperazine|Cinnarizin|1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine|Cinnarizine|Cinarizina|1-Benzhydryl-4-cinnamylpiperazin|Cinnarizinum	-	DRUGBANK	DB00568	C26H28N2	small molecule	N07CA02|N07CA52	298-57-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DERZBLKQOCDDDZ-JLHYYAGUSA-N
8351	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Kvernmo T (2008)	18691132	174662	579	Lisuride	N'-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethylurea|Lisuridum|Lisuride|Lisurid|Lisurida	-	DRUGBANK	DB00589	C20H26N4O	small molecule	G02CB02|N02CA07	18016-80-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BKRGVLQUQGGVSM-KBXCAEBGSA-N
8490	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	589	Thiopental	Thiopentobarbital|(+-)-Thiopental|Tiopentale|Sodium Pentothal|Thiopental|2-Thio-5-ethyl-5-sec-pentylbarbituric acid|Omexolon|Thiomebumalum|Penthiobarbital|5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione|Pentothiobarbital|Thiopentobarbitone|Bitaryl|Thiopentobarbituric acid|Thiopentone|Trapanal	pentothal inj 25mg/ml|pentotha	DRUGBANK	DB00599	C11H18N2O2S	small molecule	N05CA19|N01AF03	76-75-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	IUJDSEJGGMCXSG-UHFFFAOYSA-N
8491	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	589	Thiopental	Thiopentobarbital|(+-)-Thiopental|Tiopentale|Sodium Pentothal|Thiopental|2-Thio-5-ethyl-5-sec-pentylbarbituric acid|Omexolon|Thiomebumalum|Penthiobarbital|5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione|Pentothiobarbital|Thiopentobarbitone|Bitaryl|Thiopentobarbituric acid|Thiopentone|Trapanal	pentothal inj 25mg/ml|pentotha	DRUGBANK	DB00599	C11H18N2O2S	small molecule	N05CA19|N01AF03	76-75-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	IUJDSEJGGMCXSG-UHFFFAOYSA-N
8669	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Posadas EM (2007)	17559139	177333	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8670	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Lee JL (2006)	16865565	177335	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8671	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Rutkowski P (2007)	17458563	177334	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8672	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	De Giorgi U (2007)	17369583	177337	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8673	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Dy GK (2005)	16087693	177336	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8674	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	multitarget	target	Posadas EM (2007)	17559139	177333	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8675	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	multitarget	target	Lee JL (2006)	16865565	177335	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8676	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	multitarget	target	Rutkowski P (2007)	17458563	177334	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8677	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	multitarget	target	De Giorgi U (2007)	17369583	177337	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8678	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	multitarget	target	Dy GK (2005)	16087693	177336	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8695	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	antagonist	target	Borbenyi Z (2005)	15921304	177356	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8696	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	antagonist	target	Tefferi A (2005)	15995325	177355	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8697	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	antagonist	target	Yi ES (2005)	15894928	177354	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8698	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	antagonist	target	Chen LL (2005)	15946589	177353	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8699	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	antagonist	target	Corless CL (2005)	15928335	177352	609	Imatinib	Imatinibum|alpha-(4-Methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-P-toluidide|4-(4-METHYL-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide|Imatinib Methansulfonate|STI 571|Imatinib	imatinib mesylate|pms-imatinib	DRUGBANK	DB00619	C29H31N7O	small molecule	L01XE01	152459-95-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KTUFNOKKBVMGRW-UHFFFAOYSA-N
8742	106524	2	-	A2M	A2MD|CPAMD5|FWP007|S863-7	9606	Homo sapiens	inhibitor	target	Maxfield FR (1979)	42903	177414	616	Bacitracin	Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-L-leucine)-|Bacitracin a2a	bacitin|walgreenstriple antibi	DRUGBANK	DB00626	C66H103N17O16S	small molecule	R02AB04|J01XX10|D06AX05	1405-87-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CLKOFPXJLQSYAH-ABRJDSQDSA-N
8743	106524	2	-	A2M	A2MD|CPAMD5|FWP007|S863-7	9606	Homo sapiens	inhibitor	target	Gliemann J (1983)	6187372	177415	616	Bacitracin	Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-L-leucine)-|Bacitracin a2a	bacitin|walgreenstriple antibi	DRUGBANK	DB00626	C66H103N17O16S	small molecule	R02AB04|J01XX10|D06AX05	1405-87-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CLKOFPXJLQSYAH-ABRJDSQDSA-N
8744	106524	2	-	A2M	A2MD|CPAMD5|FWP007|S863-7	9606	Homo sapiens	inhibitor	target	Dickson RB (1981)	6165617	177416	616	Bacitracin	Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-L-leucine)-|Bacitracin a2a	bacitin|walgreenstriple antibi	DRUGBANK	DB00626	C66H103N17O16S	small molecule	R02AB04|J01XX10|D06AX05	1405-87-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CLKOFPXJLQSYAH-ABRJDSQDSA-N
8745	106524	2	-	A2M	A2MD|CPAMD5|FWP007|S863-7	9606	Homo sapiens	inhibitor	target	Dickson RB (1981)	6162847	177412	616	Bacitracin	Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-L-leucine)-|Bacitracin a2a	bacitin|walgreenstriple antibi	DRUGBANK	DB00626	C66H103N17O16S	small molecule	R02AB04|J01XX10|D06AX05	1405-87-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CLKOFPXJLQSYAH-ABRJDSQDSA-N
8746	106524	2	-	A2M	A2MD|CPAMD5|FWP007|S863-7	9606	Homo sapiens	inhibitor	target	Hanover JA (1983)	6184373	177413	616	Bacitracin	Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-L-leucine)-|Bacitracin a2a	bacitin|walgreenstriple antibi	DRUGBANK	DB00626	C66H103N17O16S	small molecule	R02AB04|J01XX10|D06AX05	1405-87-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CLKOFPXJLQSYAH-ABRJDSQDSA-N
8768	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Moehler H (2002)	11752090	174537	618	Clorazepate	Clorazepic acid|7-chloro-2,3-dihydro-2,2-Dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid|Clorazepate	novo-clopate cap 3.75mg|cloraz	DRUGBANK	DB00628	C16H11ClN2O3	small molecule	-	23887-31-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XDDJGVMJFWAHJX-UHFFFAOYSA-N
8769	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	618	Clorazepate	Clorazepic acid|7-chloro-2,3-dihydro-2,2-Dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid|Clorazepate	novo-clopate cap 3.75mg|cloraz	DRUGBANK	DB00628	C16H11ClN2O3	small molecule	-	23887-31-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XDDJGVMJFWAHJX-UHFFFAOYSA-N
8780	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Moehler H (2002)	11752090	174537	618	Clorazepate	Clorazepic acid|7-chloro-2,3-dihydro-2,2-Dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid|Clorazepate	novo-clopate cap 3.75mg|cloraz	DRUGBANK	DB00628	C16H11ClN2O3	small molecule	-	23887-31-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XDDJGVMJFWAHJX-UHFFFAOYSA-N
8781	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	618	Clorazepate	Clorazepic acid|7-chloro-2,3-dihydro-2,2-Dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid|Clorazepate	novo-clopate cap 3.75mg|cloraz	DRUGBANK	DB00628	C16H11ClN2O3	small molecule	-	23887-31-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XDDJGVMJFWAHJX-UHFFFAOYSA-N
8973	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	635	Dyclonine	Dyclocaine|4'-Butoxy-3-piperidinopropiophenone|4-Butoxy-beta-piperidinopropiophenone|Dyclonin|Dycloninum|1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone|Dyclonine|4-N-Butoxy-beta-(1-piperidyl)propiophenone|3-Piperidino-4'-butoxypropiophenone|Diclonina|2-(1-Piperidyl)ethyl P-butoxyphenyl ketone	sucrets extra strength mint fl	DRUGBANK	DB00645	C18H27NO2	small molecule	N01BX02|R02AD04	586-60-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BZEWSEKUUPWQDQ-UHFFFAOYSA-N
8974	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Roghani S (1999)	10355012	177547	635	Dyclonine	Dyclocaine|4'-Butoxy-3-piperidinopropiophenone|4-Butoxy-beta-piperidinopropiophenone|Dyclonin|Dycloninum|1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone|Dyclonine|4-N-Butoxy-beta-(1-piperidyl)propiophenone|3-Piperidino-4'-butoxypropiophenone|Diclonina|2-(1-Piperidyl)ethyl P-butoxyphenyl ketone	sucrets extra strength mint fl	DRUGBANK	DB00645	C18H27NO2	small molecule	N01BX02|R02AD04	586-60-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BZEWSEKUUPWQDQ-UHFFFAOYSA-N
8975	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	635	Dyclonine	Dyclocaine|4'-Butoxy-3-piperidinopropiophenone|4-Butoxy-beta-piperidinopropiophenone|Dyclonin|Dycloninum|1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone|Dyclonine|4-N-Butoxy-beta-(1-piperidyl)propiophenone|3-Piperidino-4'-butoxypropiophenone|Diclonina|2-(1-Piperidyl)ethyl P-butoxyphenyl ketone	sucrets extra strength mint fl	DRUGBANK	DB00645	C18H27NO2	small molecule	N01BX02|R02AD04	586-60-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BZEWSEKUUPWQDQ-UHFFFAOYSA-N
8976	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Tella SR (1998)	9476974	177548	635	Dyclonine	Dyclocaine|4'-Butoxy-3-piperidinopropiophenone|4-Butoxy-beta-piperidinopropiophenone|Dyclonin|Dycloninum|1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone|Dyclonine|4-N-Butoxy-beta-(1-piperidyl)propiophenone|3-Piperidino-4'-butoxypropiophenone|Diclonina|2-(1-Piperidyl)ethyl P-butoxyphenyl ketone	sucrets extra strength mint fl	DRUGBANK	DB00645	C18H27NO2	small molecule	N01BX02|R02AD04	586-60-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BZEWSEKUUPWQDQ-UHFFFAOYSA-N
9030	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	643	Magnesium Sulfate	Magnesium sulfate (1:1)|Magnesiumsulfat|MgSO4|Magnesium sulfate anhydrous|Magnesium sulphate|Magnesium(ii) sulfate	eucalyptus scented natural eps	DRUGBANK	DB00653	MgO4S	small molecule	D11AX05|V04CC02|A06AD04|B05XA05|A12CC02	7487-88-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CSNNHWWHGAXBCP-UHFFFAOYSA-L
9031	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	643	Magnesium Sulfate	Magnesium sulfate (1:1)|Magnesiumsulfat|MgSO4|Magnesium sulfate anhydrous|Magnesium sulphate|Magnesium(ii) sulfate	eucalyptus scented natural eps	DRUGBANK	DB00653	MgO4S	small molecule	D11AX05|V04CC02|A06AD04|B05XA05|A12CC02	7487-88-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CSNNHWWHGAXBCP-UHFFFAOYSA-L
9074	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive modulator	target	Williams SH (2005)	16300039	177608	649	Acamprosate	N-acetyl homotaurine|N-Acetylhomotaurine|Acamprosato|Acamprosatum|3-Acetamido-1-propanesulfonic acid	campral|acamprosate calcium	DRUGBANK	DB00659	C5H11NO4S	small molecule	N07BB03	77337-76-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AFCGFAGUEYAMAO-UHFFFAOYSA-N
9080	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive modulator	target	Williams SH (2005)	16300039	177608	649	Acamprosate	N-acetyl homotaurine|N-Acetylhomotaurine|Acamprosato|Acamprosatum|3-Acetamido-1-propanesulfonic acid	campral|acamprosate calcium	DRUGBANK	DB00659	C5H11NO4S	small molecule	N07BB03	77337-76-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AFCGFAGUEYAMAO-UHFFFAOYSA-N
9097	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Witkiewitz K (2012)	22346357	177609	649	Acamprosate	N-acetyl homotaurine|N-Acetylhomotaurine|Acamprosato|Acamprosatum|3-Acetamido-1-propanesulfonic acid	campral|acamprosate calcium	DRUGBANK	DB00659	C5H11NO4S	small molecule	N07BB03	77337-76-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AFCGFAGUEYAMAO-UHFFFAOYSA-N
9098	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Mann K (2008)	18540918	177610	649	Acamprosate	N-acetyl homotaurine|N-Acetylhomotaurine|Acamprosato|Acamprosatum|3-Acetamido-1-propanesulfonic acid	campral|acamprosate calcium	DRUGBANK	DB00659	C5H11NO4S	small molecule	N07BB03	77337-76-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AFCGFAGUEYAMAO-UHFFFAOYSA-N
9107	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Tfelt-Hansen P (2009)	19125880	177613	651	Verapamil	D-365|Verapamil|Vrapamil|Verapamilo|Iproveratril|Tarka|CP-16533-1|Isoptin sr|Calan sr|CP-165331|Isoptin|Verelan|Covera-hs|Calan|Verapamilum	verapamil hydrochloride inject	DRUGBANK	DB00661	C27H38N2O4	small molecule	C08DA01|C08DA51|C09BB10	52-53-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SGTNSNPWRIOYBX-UHFFFAOYSA-N
9392	111576	5590	RP11-181G12.1	PRKCZ	PKC-ZETA|PKC2	9606	Homo sapiens	unknown	target	O'Brian CA (1985)	3157445	177736	665	Tamoxifen	1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene|Citofen|Valodex|Tamoxifene|Tamoxifeno|Nourytam|(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine|Crisafeno|Tamone|1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene|Retaxim|Tamoxifenum|Apo-tamox|Tamoxifne|Zemide|Istubol|Noltam|Diemon|Tamofen|trans-Tamoxifen|Tamoxasta|Oncomox|Tamoxifen|Gen-tamoxifen|(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine	pms-tamoxifen|tamone  -  (20 m	DRUGBANK	DB00675	C26H29NO	small molecule	L02BA01	10540-29-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NKANXQFJJICGDU-QPLCGJKRSA-N
9446	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	673	Midazolam	Buccolam|Midazolam|Dormicum|Midazolamum	midazolam injection sdz|midazo	DRUGBANK	DB00683	C18H13ClFN3	small molecule	N05CD08	59467-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DDLIGBOFAVUZHB-UHFFFAOYSA-N
9447	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	673	Midazolam	Buccolam|Midazolam|Dormicum|Midazolamum	midazolam injection sdz|midazo	DRUGBANK	DB00683	C18H13ClFN3	small molecule	N05CD08	59467-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DDLIGBOFAVUZHB-UHFFFAOYSA-N
9454	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	673	Midazolam	Buccolam|Midazolam|Dormicum|Midazolamum	midazolam injection sdz|midazo	DRUGBANK	DB00683	C18H13ClFN3	small molecule	N05CD08	59467-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DDLIGBOFAVUZHB-UHFFFAOYSA-N
9455	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	673	Midazolam	Buccolam|Midazolam|Dormicum|Midazolamum	midazolam injection sdz|midazo	DRUGBANK	DB00683	C18H13ClFN3	small molecule	N05CD08	59467-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DDLIGBOFAVUZHB-UHFFFAOYSA-N
9518	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	680	Flurazepam	Insumin|Flurazpam|Flurazepam|Flurazepamum	dalmane|somnol 30mg|flurazepam	DRUGBANK	DB00690	C21H23ClFN3O	small molecule	N05CD01	17617-23-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SAADBVWGJQAEFS-UHFFFAOYSA-N
9519	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	680	Flurazepam	Insumin|Flurazpam|Flurazepam|Flurazepamum	dalmane|somnol 30mg|flurazepam	DRUGBANK	DB00690	C21H23ClFN3O	small molecule	N05CD01	17617-23-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SAADBVWGJQAEFS-UHFFFAOYSA-N
9526	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	680	Flurazepam	Insumin|Flurazpam|Flurazepam|Flurazepamum	dalmane|somnol 30mg|flurazepam	DRUGBANK	DB00690	C21H23ClFN3O	small molecule	N05CD01	17617-23-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SAADBVWGJQAEFS-UHFFFAOYSA-N
9527	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	680	Flurazepam	Insumin|Flurazpam|Flurazepam|Flurazepamum	dalmane|somnol 30mg|flurazepam	DRUGBANK	DB00690	C21H23ClFN3O	small molecule	N05CD01	17617-23-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SAADBVWGJQAEFS-UHFFFAOYSA-N
9610	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Bigal ME (2003)	12525272	177883	686	Ergotamine	Ergotamina|Ergotamine|Ergotamin|Gynergen|12'-Hydroxy-2'-methyl-5'alpha-(phenylmethyl)ergotaman-3',6',18-trione|Ergotaminum|(5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trione	gravergol capsules|ergomar sub	DRUGBANK	DB00696	C33H35N5O5	small molecule	N02CA02|N02CA72|N02CA52	113-15-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XCGSFFUVFURLIX-VFGNJEKYSA-N
9750	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Kvernmo T (2008)	18691132	174662	704	Apomorphine	(-)-10,11-Dihydroxyaporphine|R-()-apomorphine|(6AR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol|()-10,11-dihydroxyaporphine|R-(-)-Apomorphine|(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol|Apomorphin	movapo|apokyn	DRUGBANK	DB00714	C17H17NO2	small molecule	G04BE07|N04BC07	58-00-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VMWNQDUVQKEIOC-CYBMUJFWSA-N
9751	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Chen X (2002)	11752352	171740	704	Apomorphine	(-)-10,11-Dihydroxyaporphine|R-()-apomorphine|(6AR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol|()-10,11-dihydroxyaporphine|R-(-)-Apomorphine|(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol|Apomorphin	movapo|apokyn	DRUGBANK	DB00714	C17H17NO2	small molecule	G04BE07|N04BC07	58-00-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VMWNQDUVQKEIOC-CYBMUJFWSA-N
9821	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	711	Procaine	Procaina|4-aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl 4-aminobenzoate|2-Diethylaminoethyl p-aminobenzoate|Vitamin H3|Procainum|Novocaine|p-Aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl p-aminobenzoate	novocain 20 mg/ml|novocain liq	DRUGBANK	DB00721	C13H20N2O2	small molecule	S01HA05|C05AD05|N01BA52|N01BA02	59-46-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MFDFERRIHVXMIY-UHFFFAOYSA-N
9822	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Katalymov LL (1995)	8581044	178030	711	Procaine	Procaina|4-aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl 4-aminobenzoate|2-Diethylaminoethyl p-aminobenzoate|Vitamin H3|Procainum|Novocaine|p-Aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl p-aminobenzoate	novocain 20 mg/ml|novocain liq	DRUGBANK	DB00721	C13H20N2O2	small molecule	S01HA05|C05AD05|N01BA52|N01BA02	59-46-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MFDFERRIHVXMIY-UHFFFAOYSA-N
9823	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Creveling CR (1990)	2167458	178031	711	Procaine	Procaina|4-aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl 4-aminobenzoate|2-Diethylaminoethyl p-aminobenzoate|Vitamin H3|Procainum|Novocaine|p-Aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl p-aminobenzoate	novocain 20 mg/ml|novocain liq	DRUGBANK	DB00721	C13H20N2O2	small molecule	S01HA05|C05AD05|N01BA52|N01BA02	59-46-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MFDFERRIHVXMIY-UHFFFAOYSA-N
9824	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	711	Procaine	Procaina|4-aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl 4-aminobenzoate|2-Diethylaminoethyl p-aminobenzoate|Vitamin H3|Procainum|Novocaine|p-Aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl p-aminobenzoate	novocain 20 mg/ml|novocain liq	DRUGBANK	DB00721	C13H20N2O2	small molecule	S01HA05|C05AD05|N01BA52|N01BA02	59-46-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MFDFERRIHVXMIY-UHFFFAOYSA-N
9825	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Braeu ME (1998)	9768788	178029	711	Procaine	Procaina|4-aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl 4-aminobenzoate|2-Diethylaminoethyl p-aminobenzoate|Vitamin H3|Procainum|Novocaine|p-Aminobenzoic acid 2-diethylaminoethyl ester|-(diethylamino)ethyl p-aminobenzoate	novocain 20 mg/ml|novocain liq	DRUGBANK	DB00721	C13H20N2O2	small molecule	S01HA05|C05AD05|N01BA52|N01BA02	59-46-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MFDFERRIHVXMIY-UHFFFAOYSA-N
9894	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	binder	target	Berger M (1996)	8863001	178063	716	Trimipramine	Trimipramine|Trimeproprimine|RP-7162|Trimipramina|10,11-dihydro-N,N,beta-Trimethyl-5H-dibenz[b,F]azepine-5-propanamine|5-(gamma-dimethylamino-beta-Methylpropyl)-10,11-dihydro-5H-dibenzo[b,F]azepine|Trimeprimina|Trimeprimine|Trimipraminum|beta-Methylimipramine|5-[3-(dimethylamino)-2-Methylpropyl]-10,11-dihydro-5H-dibenz[b,F]azepine|Sapilent	nu-trimipramine tab 100mg|trim	DRUGBANK	DB00726	C20H26N2	small molecule	N06AA06	739-71-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZSCDBOWYZJWBIY-UHFFFAOYSA-N
10327	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Juwana YB (2010)	20210689	178329	765	Tirofiban	Tirofibanum|N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine|Tirofiban|(2S)-2-(Butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid	aggrastat	DRUGBANK	DB00775	C22H36N2O5S	small molecule	B01AC17	144494-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	COKMIXFXJJXBQG-NRFANRHFSA-N
10328	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	765	Tirofiban	Tirofibanum|N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine|Tirofiban|(2S)-2-(Butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid	aggrastat	DRUGBANK	DB00775	C22H36N2O5S	small molecule	B01AC17	144494-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	COKMIXFXJJXBQG-NRFANRHFSA-N
10329	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	antagonist	target	Berman HM (2000)	10592235	172122	765	Tirofiban	Tirofibanum|N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine|Tirofiban|(2S)-2-(Butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid	aggrastat	DRUGBANK	DB00775	C22H36N2O5S	small molecule	B01AC17	144494-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	COKMIXFXJJXBQG-NRFANRHFSA-N
10369	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Beltinger J (2006)	16595573	178341	768	Roxithromycin	Roxitromicina|Roxithromycin|(9e)-Erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime)|Roxithromycinum|Roxithromycine	-	DRUGBANK	DB00778	C41H76N2O15	small molecule	J01FA06	80214-83-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RXZBMPWDPOLZGW-XMRMVWPWSA-N
10370	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Kaufmann P (2006)	17164692	178340	768	Roxithromycin	Roxitromicina|Roxithromycin|(9e)-Erythromycin 9-(O-((2-methoxyethoxy)methyl)oxime)|Roxithromycinum|Roxithromycine	-	DRUGBANK	DB00778	C41H76N2O15	small molecule	J01FA06	80214-83-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RXZBMPWDPOLZGW-XMRMVWPWSA-N
10466	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	inhibitor	target	Heath EI (2000)	10852638	178392	776	Marimastat	BB-2516|Marimastat	-	DRUGBANK	DB00786	C15H29N3O5	small molecule	-	154039-60-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OCSMOTCMPXTDND-OUAUKWLOSA-N
10467	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	inhibitor	target	Belotti D (2000)	10669951	178393	776	Marimastat	BB-2516|Marimastat	-	DRUGBANK	DB00786	C15H29N3O5	small molecule	-	154039-60-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OCSMOTCMPXTDND-OUAUKWLOSA-N
10534	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	784	Primidone	Primidona|Primidonum|Mysoline|Primidone|Desoxyphenobarbital|Primaclone|Primidon|5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione	mysoline|primidone|sertan tab 	DRUGBANK	DB00794	C12H14N2O2	small molecule	N03AA03	125-33-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DQMZLTXERSFNPB-UHFFFAOYSA-N
10535	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	784	Primidone	Primidona|Primidonum|Mysoline|Primidone|Desoxyphenobarbital|Primaclone|Primidon|5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione	mysoline|primidone|sertan tab 	DRUGBANK	DB00794	C12H14N2O2	small molecule	N03AA03	125-33-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DQMZLTXERSFNPB-UHFFFAOYSA-N
10627	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Imming P (2006)	17016423	171742	790	Fenoldopam	Fenoldopam|Fenoldopamum|Fnoldopam	corlopam	DRUGBANK	DB00800	C16H16ClNO3	small molecule	C01CA19	67227-56-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	TVURRHSHRRELCG-UHFFFAOYSA-N
10628	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Overington JP (2006)	17139284	171741	790	Fenoldopam	Fenoldopam|Fenoldopamum|Fnoldopam	corlopam	DRUGBANK	DB00800	C16H16ClNO3	small molecule	C01CA19	67227-56-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	TVURRHSHRRELCG-UHFFFAOYSA-N
10629	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Dhasmana KM (1993)	8103596	178446	790	Fenoldopam	Fenoldopam|Fenoldopamum|Fnoldopam	corlopam	DRUGBANK	DB00800	C16H16ClNO3	small molecule	C01CA19	67227-56-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	TVURRHSHRRELCG-UHFFFAOYSA-N
10630	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Zeng C (2009)	19293728	178445	790	Fenoldopam	Fenoldopam|Fenoldopamum|Fnoldopam	corlopam	DRUGBANK	DB00800	C16H16ClNO3	small molecule	C01CA19	67227-56-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	TVURRHSHRRELCG-UHFFFAOYSA-N
10641	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Iorio LC (1984)	6738302	178448	791	Halazepam	Paxipam|Halazpam|Halazepamum|Halazepam	-	DRUGBANK	DB00801	C17H12ClF3N2O	small molecule	N05BA13	23092-17-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WYCLKVQLVUQKNZ-UHFFFAOYSA-N
10642	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Wamsley JK (1985)	2867566	178449	791	Halazepam	Paxipam|Halazpam|Halazepamum|Halazepam	-	DRUGBANK	DB00801	C17H12ClF3N2O	small molecule	N05BA13	23092-17-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WYCLKVQLVUQKNZ-UHFFFAOYSA-N
10714	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	797	Proparacaine	Proxymetacaine|Proximetacaina|Proxymetacainum	alcaine|proparacaine hydrochlo	DRUGBANK	DB00807	C16H26N2O3	small molecule	S01HA04	499-67-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KCLANYCVBBTKTO-UHFFFAOYSA-N
10715	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	797	Proparacaine	Proxymetacaine|Proximetacaina|Proxymetacainum	alcaine|proparacaine hydrochlo	DRUGBANK	DB00807	C16H26N2O3	small molecule	S01HA04	499-67-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KCLANYCVBBTKTO-UHFFFAOYSA-N
10716	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Tella SR (1998)	9476974	177548	797	Proparacaine	Proxymetacaine|Proximetacaina|Proxymetacainum	alcaine|proparacaine hydrochlo	DRUGBANK	DB00807	C16H26N2O3	small molecule	S01HA04	499-67-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KCLANYCVBBTKTO-UHFFFAOYSA-N
10797	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Franks NP (2006)	16402123	174522	808	Propofol	Propofol|Diprivan|Disoprofol|2,6-Bis(1-methylethyl)phenol|Propofolum|2,6-Diisopropylphenol|Rapinovet|Disoprivan	pms-propofol|propofol-ii injec	DRUGBANK	DB00818	C12H18O	small molecule	N01AX10	2078-54-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OLBCVFGFOZPWHH-UHFFFAOYSA-N
10880	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	819	Diazepam	Diazepam|7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one|Methyl diazepinone|Valium	pms-diazepam solution 1mg/ml|d	DRUGBANK	DB00829	C16H13ClN2O	small molecule	N05BA01	439-14-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AAOVKJBEBIDNHE-UHFFFAOYSA-N
10881	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	819	Diazepam	Diazepam|7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one|Methyl diazepinone|Valium	pms-diazepam solution 1mg/ml|d	DRUGBANK	DB00829	C16H13ClN2O	small molecule	N05BA01	439-14-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AAOVKJBEBIDNHE-UHFFFAOYSA-N
11013	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	832	Oxazepam	Oxazepam|Tazepam|Serax|(+-)-Oxazepam|(RS)-Oxazepam	oxazepam 15mg tablets|apo oxaz	DRUGBANK	DB00842	C15H11ClN2O2	small molecule	N05BA04	604-75-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ADIMAYPTOBDMTL-UHFFFAOYSA-N
11014	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	832	Oxazepam	Oxazepam|Tazepam|Serax|(+-)-Oxazepam|(RS)-Oxazepam	oxazepam 15mg tablets|apo oxaz	DRUGBANK	DB00842	C15H11ClN2O2	small molecule	N05BA04	604-75-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ADIMAYPTOBDMTL-UHFFFAOYSA-N
11021	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	832	Oxazepam	Oxazepam|Tazepam|Serax|(+-)-Oxazepam|(RS)-Oxazepam	oxazepam 15mg tablets|apo oxaz	DRUGBANK	DB00842	C15H11ClN2O2	small molecule	N05BA04	604-75-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ADIMAYPTOBDMTL-UHFFFAOYSA-N
11022	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	832	Oxazepam	Oxazepam|Tazepam|Serax|(+-)-Oxazepam|(RS)-Oxazepam	oxazepam 15mg tablets|apo oxaz	DRUGBANK	DB00842	C15H11ClN2O2	small molecule	N05BA04	604-75-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ADIMAYPTOBDMTL-UHFFFAOYSA-N
11129	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	839	Methylphenobarbital	Mephobarbital|Mebaral|5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Methylphenobarbitone|Methylphenobarbital|Enphenemal|Mthylphnobarbital|Metilfenobarbitale|5-Ethyl-1-methyl-5-phenylbarbituric acid|Metilfenobarbital|N-Methylphenobarbital|Mephobarbitone|5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione|1-Methylphenobarbital|Methylphenobarbitalum	-	DRUGBANK	DB00849	C13H14N2O3	small molecule	N03AA01	115-38-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ALARQZQTBTVLJV-UHFFFAOYSA-N
11130	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Olsen RW (2011)	21194017	178688	839	Methylphenobarbital	Mephobarbital|Mebaral|5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Methylphenobarbitone|Methylphenobarbital|Enphenemal|Mthylphnobarbital|Metilfenobarbitale|5-Ethyl-1-methyl-5-phenylbarbituric acid|Metilfenobarbital|N-Methylphenobarbital|Mephobarbitone|5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione|1-Methylphenobarbital|Methylphenobarbitalum	-	DRUGBANK	DB00849	C13H14N2O3	small molecule	N03AA01	115-38-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ALARQZQTBTVLJV-UHFFFAOYSA-N
11131	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	839	Methylphenobarbital	Mephobarbital|Mebaral|5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Methylphenobarbitone|Methylphenobarbital|Enphenemal|Mthylphnobarbital|Metilfenobarbitale|5-Ethyl-1-methyl-5-phenylbarbituric acid|Metilfenobarbital|N-Methylphenobarbital|Mephobarbitone|5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione|1-Methylphenobarbital|Methylphenobarbitalum	-	DRUGBANK	DB00849	C13H14N2O3	small molecule	N03AA01	115-38-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ALARQZQTBTVLJV-UHFFFAOYSA-N
11440	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	882	Oxybuprocaine	Oxyriprocaine|BNX|4-Amino-3-N-butoxy-benzoesaeure-diaethylaminoaethylester|4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester|Oxibuprocaina|Benoxil|4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid|Butoxyaminobenzoyldiethylaminoethanol|Oxybuprocainum|Oxybucaine|Benoxinate	fluress|fluorox|minims benoxin	DRUGBANK	DB00892	C17H28N2O3	small molecule	D04AB03|S01HA02	99-43-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CMHHMUWAYWTMGS-UHFFFAOYSA-N
11441	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Hung CH (2009)	19429093	178921	882	Oxybuprocaine	Oxyriprocaine|BNX|4-Amino-3-N-butoxy-benzoesaeure-diaethylaminoaethylester|4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester|Oxibuprocaina|Benoxil|4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid|Butoxyaminobenzoyldiethylaminoethanol|Oxybuprocainum|Oxybucaine|Benoxinate	fluress|fluorox|minims benoxin	DRUGBANK	DB00892	C17H28N2O3	small molecule	D04AB03|S01HA02	99-43-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CMHHMUWAYWTMGS-UHFFFAOYSA-N
11442	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	882	Oxybuprocaine	Oxyriprocaine|BNX|4-Amino-3-N-butoxy-benzoesaeure-diaethylaminoaethylester|4-Amino-3-butoxy-benzoic acid 2-diethylamino-ethyl ester|Oxibuprocaina|Benoxil|4-Amino-3-butoxy-2-(diethylamino)ethyl ester benzoic acid|Butoxyaminobenzoyldiethylaminoethanol|Oxybuprocainum|Oxybucaine|Benoxinate	fluress|fluorox|minims benoxin	DRUGBANK	DB00892	C17H28N2O3	small molecule	D04AB03|S01HA02	99-43-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CMHHMUWAYWTMGS-UHFFFAOYSA-N
11470	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	887	Triazolam	Triazolam|Halcion|Triazolamum	penta-triazolam tablets|halcio	DRUGBANK	DB00897	C17H12Cl2N4	small molecule	N05CD05	28911-01-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JOFWLTCLBGQGBO-UHFFFAOYSA-N
11471	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	887	Triazolam	Triazolam|Halcion|Triazolamum	penta-triazolam tablets|halcio	DRUGBANK	DB00897	C17H12Cl2N4	small molecule	N05CD05	28911-01-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JOFWLTCLBGQGBO-UHFFFAOYSA-N
11478	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	887	Triazolam	Triazolam|Halcion|Triazolamum	penta-triazolam tablets|halcio	DRUGBANK	DB00897	C17H12Cl2N4	small molecule	N05CD05	28911-01-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JOFWLTCLBGQGBO-UHFFFAOYSA-N
11479	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	887	Triazolam	Triazolam|Halcion|Triazolamum	penta-triazolam tablets|halcio	DRUGBANK	DB00897	C17H12Cl2N4	small molecule	N05CD05	28911-01-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JOFWLTCLBGQGBO-UHFFFAOYSA-N
11617	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	897	Cocaine	Methyl benzoylecgonine|Cocainum|Cocaine|Kokain|L-Cocain|2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylate benzoate (ester)|Benzoylmethylecgonine|Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate|Cocain|beta-Cocain|L-Cocaine|(-)-Cocaine|()-cocaine|Neurocaine|[1R-(Exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester|Cocaina	cocaine hydrochloride top sol 	DRUGBANK	DB00907	C17H21NO4	small molecule	N01BC01|S02DA02|R02AD03|S01HA01	50-36-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZPUCINDJVBIVPJ-LJISPDSOSA-N
11618	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	897	Cocaine	Methyl benzoylecgonine|Cocainum|Cocaine|Kokain|L-Cocain|2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylate benzoate (ester)|Benzoylmethylecgonine|Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate|Cocain|beta-Cocain|L-Cocaine|(-)-Cocaine|()-cocaine|Neurocaine|[1R-(Exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester|Cocaina	cocaine hydrochloride top sol 	DRUGBANK	DB00907	C17H21NO4	small molecule	N01BC01|S02DA02|R02AD03|S01HA01	50-36-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZPUCINDJVBIVPJ-LJISPDSOSA-N
11763	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Leppik IE (2004)	15511691	179038	899	Zonisamide	1,2-Benzisoxazole-3-methanesulfonamide|Zonisamida|Zonisamidum|Benzo[D]isoxazol-3-yl-methanesulfonamide|3-(Sulfamoylmethyl)-1,2-benzisoxazole	zonegran|zonisamide	DRUGBANK	DB00909	C8H8N2O3S	small molecule	N03AX15	68291-97-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UBQNRHZMVUUOMG-UHFFFAOYSA-N
11764	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Kothare SV (2008)	18433351	179039	899	Zonisamide	1,2-Benzisoxazole-3-methanesulfonamide|Zonisamida|Zonisamidum|Benzo[D]isoxazol-3-yl-methanesulfonamide|3-(Sulfamoylmethyl)-1,2-benzisoxazole	zonegran|zonisamide	DRUGBANK	DB00909	C8H8N2O3S	small molecule	N03AX15	68291-97-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UBQNRHZMVUUOMG-UHFFFAOYSA-N
11765	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Sobieszek G (2004)	14704463	179034	899	Zonisamide	1,2-Benzisoxazole-3-methanesulfonamide|Zonisamida|Zonisamidum|Benzo[D]isoxazol-3-yl-methanesulfonamide|3-(Sulfamoylmethyl)-1,2-benzisoxazole	zonegran|zonisamide	DRUGBANK	DB00909	C8H8N2O3S	small molecule	N03AX15	68291-97-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UBQNRHZMVUUOMG-UHFFFAOYSA-N
11766	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Schulze-Bonhage A (2010)	20001433	179035	899	Zonisamide	1,2-Benzisoxazole-3-methanesulfonamide|Zonisamida|Zonisamidum|Benzo[D]isoxazol-3-yl-methanesulfonamide|3-(Sulfamoylmethyl)-1,2-benzisoxazole	zonegran|zonisamide	DRUGBANK	DB00909	C8H8N2O3S	small molecule	N03AX15	68291-97-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UBQNRHZMVUUOMG-UHFFFAOYSA-N
11767	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Zaccara G (2009)	19557119	179036	899	Zonisamide	1,2-Benzisoxazole-3-methanesulfonamide|Zonisamida|Zonisamidum|Benzo[D]isoxazol-3-yl-methanesulfonamide|3-(Sulfamoylmethyl)-1,2-benzisoxazole	zonegran|zonisamide	DRUGBANK	DB00909	C8H8N2O3S	small molecule	N03AX15	68291-97-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UBQNRHZMVUUOMG-UHFFFAOYSA-N
11768	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Janszky J (2009)	20025128	179037	899	Zonisamide	1,2-Benzisoxazole-3-methanesulfonamide|Zonisamida|Zonisamidum|Benzo[D]isoxazol-3-yl-methanesulfonamide|3-(Sulfamoylmethyl)-1,2-benzisoxazole	zonegran|zonisamide	DRUGBANK	DB00909	C8H8N2O3S	small molecule	N03AX15	68291-97-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UBQNRHZMVUUOMG-UHFFFAOYSA-N
11769	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	inhibitor	target	Sonsalla PK (2010)	19948168	179031	899	Zonisamide	1,2-Benzisoxazole-3-methanesulfonamide|Zonisamida|Zonisamidum|Benzo[D]isoxazol-3-yl-methanesulfonamide|3-(Sulfamoylmethyl)-1,2-benzisoxazole	zonegran|zonisamide	DRUGBANK	DB00909	C8H8N2O3S	small molecule	N03AX15	68291-97-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UBQNRHZMVUUOMG-UHFFFAOYSA-N
12156	113010	7157	-	TP53	BCC7|LFS1|P53|TRP53	9606	Homo sapiens	acetylation	target	Alfonso LF (2009)	21475861	179244	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12206	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	939	Felbamate	Felbamatum|2-Phenyl-1,3-propanediol dicarbamate|Carbamic acid 2-phenyltrimethylene ester|Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester|Felbamato|Felbamate	felbamate|felbatol	DRUGBANK	DB00949	C11H14N2O4	small molecule	N03AX10	25451-15-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WKGXYQFOCVYPAC-UHFFFAOYSA-N
12317	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	951	Mepivacaine	1-methyl-2',6'-pipecoloxylidide|Carbocaine|Mepivacainum|Mepivacaina|N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide|DL-Mepivacaine|(+-)-1-Methyl-2',6'-pipecoloxylidide|N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide	mepivacaine hydrochloride and 	DRUGBANK	DB00961	C15H22N2O	small molecule	N01BB03|N01BB53	96-88-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	INWLQCZOYSRPNW-UHFFFAOYSA-N
12318	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Leffler A (2010)	20044988	179360	951	Mepivacaine	1-methyl-2',6'-pipecoloxylidide|Carbocaine|Mepivacainum|Mepivacaina|N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide|DL-Mepivacaine|(+-)-1-Methyl-2',6'-pipecoloxylidide|N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide	mepivacaine hydrochloride and 	DRUGBANK	DB00961	C15H22N2O	small molecule	N01BB03|N01BB53	96-88-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	INWLQCZOYSRPNW-UHFFFAOYSA-N
12319	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	951	Mepivacaine	1-methyl-2',6'-pipecoloxylidide|Carbocaine|Mepivacainum|Mepivacaina|N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide|DL-Mepivacaine|(+-)-1-Methyl-2',6'-pipecoloxylidide|N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide	mepivacaine hydrochloride and 	DRUGBANK	DB00961	C15H22N2O	small molecule	N01BB03|N01BB53	96-88-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	INWLQCZOYSRPNW-UHFFFAOYSA-N
12526	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Ostadali MR (2004)	17301410	179521	978	Dopamine	4-(2-Aminoethyl)benzene-1,2-diol|Deoxyepinephrine|4-(2-Aminoethyl)pyrocatechol|Dopaminum|4-(2-Aminoethyl)-1,2-benzenediol|2-(3,4-Dihydroxyphenyl)ethylamine|Dopamina|Dophamine|Dopamine|3,4-Dihydroxyphenethylamine|Dopamin|Oxytyramine|Hydroxytyramine|4-(2-Aminoethyl)catechol|3-Hydroxytyramine|Hydroxytyramin	dopamine hydrochloride and dex	DRUGBANK	DB00988	C8H11NO2	small molecule	C01CA04	51-61-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VYFYYTLLBUKUHU-UHFFFAOYSA-N
12527	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Huebner H (2000)	10691700	179533	978	Dopamine	4-(2-Aminoethyl)benzene-1,2-diol|Deoxyepinephrine|4-(2-Aminoethyl)pyrocatechol|Dopaminum|4-(2-Aminoethyl)-1,2-benzenediol|2-(3,4-Dihydroxyphenyl)ethylamine|Dopamina|Dophamine|Dopamine|3,4-Dihydroxyphenethylamine|Dopamin|Oxytyramine|Hydroxytyramine|4-(2-Aminoethyl)catechol|3-Hydroxytyramine|Hydroxytyramin	dopamine hydrochloride and dex	DRUGBANK	DB00988	C8H11NO2	small molecule	C01CA04	51-61-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VYFYYTLLBUKUHU-UHFFFAOYSA-N
12605	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	unknown	target	Shimoyama M (2000)	10781913	179586	986	Gabapentin	Gabapentine|Gabapentin GR|Gabapentina|Gabapetin|Neurontin|Gabapentino|1-(Aminomethyl)cyclohexaneacetic acid|Gabapentinum	gapeam budibac|neurontin 600mg	DRUGBANK	DB00996	C9H17NO2	small molecule	N03AX12	60142-96-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UGJMXCAKCUNAIE-UHFFFAOYSA-N
12664	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	992	Levobupivacaine	Levobupivacaine|(-)-Bupivacaine|(S)-1-Butyl-2',6'-pipecoloxylidide|(S)-Bupivacaine|L-(-)-1-Butyl-2',6'-pipecoloxylidide|L-(-)-Bupivacaine	-	DRUGBANK	DB01002	C18H28N2O	small molecule	N01BB10	27262-47-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEBVLXFERQHONN-INIZCTEOSA-N
12665	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Vladimirov M (2000)	10969308	179612	992	Levobupivacaine	Levobupivacaine|(-)-Bupivacaine|(S)-1-Butyl-2',6'-pipecoloxylidide|(S)-Bupivacaine|L-(-)-1-Butyl-2',6'-pipecoloxylidide|L-(-)-Bupivacaine	-	DRUGBANK	DB01002	C18H28N2O	small molecule	N01BB10	27262-47-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEBVLXFERQHONN-INIZCTEOSA-N
12666	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	992	Levobupivacaine	Levobupivacaine|(-)-Bupivacaine|(S)-1-Butyl-2',6'-pipecoloxylidide|(S)-Bupivacaine|L-(-)-1-Butyl-2',6'-pipecoloxylidide|L-(-)-Bupivacaine	-	DRUGBANK	DB01002	C18H28N2O	small molecule	N01BB10	27262-47-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEBVLXFERQHONN-INIZCTEOSA-N
12667	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Braeu ME (2000)	11094008	179614	992	Levobupivacaine	Levobupivacaine|(-)-Bupivacaine|(S)-1-Butyl-2',6'-pipecoloxylidide|(S)-Bupivacaine|L-(-)-1-Butyl-2',6'-pipecoloxylidide|L-(-)-Bupivacaine	-	DRUGBANK	DB01002	C18H28N2O	small molecule	N01BB10	27262-47-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEBVLXFERQHONN-INIZCTEOSA-N
12668	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Ueta K (2006)	16418020	179613	992	Levobupivacaine	Levobupivacaine|(-)-Bupivacaine|(S)-1-Butyl-2',6'-pipecoloxylidide|(S)-Bupivacaine|L-(-)-1-Butyl-2',6'-pipecoloxylidide|L-(-)-Bupivacaine	-	DRUGBANK	DB01002	C18H28N2O	small molecule	N01BB10	27262-47-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEBVLXFERQHONN-INIZCTEOSA-N
12754	115371	10060	-	ABCC9	ABC37|ATFB12|CANTU|CMD1O|SUR2	9606	Homo sapiens	modulator	target	Zhao JL (2006)	16845255	174020	1006	Glyburide	1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea|Glibenclamide|Glibenclamidum|Micronase|Diabeta|1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea|Glibenclamida|Glyburide|5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide|Glynase	diabeta 5mg|euglucon|ntp-glybu	DRUGBANK	DB01016	C23H28ClN3O5S	small molecule	A10BB01	10238-21-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
12755	115371	10060	-	ABCC9	ABC37|ATFB12|CANTU|CMD1O|SUR2	9606	Homo sapiens	modulator	target	Rainbow RD (2004)	14672537	179663	1006	Glyburide	1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea|Glibenclamide|Glibenclamidum|Micronase|Diabeta|1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea|Glibenclamida|Glyburide|5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide|Glynase	diabeta 5mg|euglucon|ntp-glybu	DRUGBANK	DB01016	C23H28ClN3O5S	small molecule	A10BB01	10238-21-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
12756	115371	10060	-	ABCC9	ABC37|ATFB12|CANTU|CMD1O|SUR2	9606	Homo sapiens	modulator	target	Felsch H (2004)	15023854	179662	1006	Glyburide	1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea|Glibenclamide|Glibenclamidum|Micronase|Diabeta|1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea|Glibenclamida|Glyburide|5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide|Glynase	diabeta 5mg|euglucon|ntp-glybu	DRUGBANK	DB01016	C23H28ClN3O5S	small molecule	A10BB01	10238-21-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
12757	115371	10060	-	ABCC9	ABC37|ATFB12|CANTU|CMD1O|SUR2	9606	Homo sapiens	modulator	target	Hambrock A (2002)	12145099	179665	1006	Glyburide	1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea|Glibenclamide|Glibenclamidum|Micronase|Diabeta|1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea|Glibenclamida|Glyburide|5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide|Glynase	diabeta 5mg|euglucon|ntp-glybu	DRUGBANK	DB01016	C23H28ClN3O5S	small molecule	A10BB01	10238-21-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
12758	115371	10060	-	ABCC9	ABC37|ATFB12|CANTU|CMD1O|SUR2	9606	Homo sapiens	modulator	target	Wang YH (2007)	17294036	179664	1006	Glyburide	1-((P-(2-(5-chloro-O-Anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea|Glibenclamide|Glibenclamidum|Micronase|Diabeta|1-(P-(2-(5-chloro-2-Methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea|Glibenclamida|Glyburide|5-chloro-N-(2-(4-((((Cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide|Glynase	diabeta 5mg|euglucon|ntp-glybu	DRUGBANK	DB01016	C23H28ClN3O5S	small molecule	A10BB01	10238-21-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
12867	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Peterson BZ (2006)	16675661	174772	1013	Felodipine	(+-)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate|4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester|Felodipinum|Felodipina|Felodipine|3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate	sandoz felodipine|renedil|rene	DRUGBANK	DB01023	C18H19Cl2NO4	small molecule	C08CA02|C09BB05	72509-76-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RZTAMFZIAATZDJ-UHFFFAOYSA-N
13021	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	1023	Cerulenin	Cerulenin|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide	-	DRUGBANK	DB01034	C12H17NO3	small molecule	-	17397-89-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GVEZIHKRYBHEFX-NQQPLRFYSA-N
13022	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Oskouian B (1999)	10102370	47998	1023	Cerulenin	Cerulenin|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide	-	DRUGBANK	DB01034	C12H17NO3	small molecule	-	17397-89-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GVEZIHKRYBHEFX-NQQPLRFYSA-N
13023	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Heiligtag SJ (2002)	12181752	179812	1023	Cerulenin	Cerulenin|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide	-	DRUGBANK	DB01034	C12H17NO3	small molecule	-	17397-89-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GVEZIHKRYBHEFX-NQQPLRFYSA-N
13024	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Lupu R (2006)	17168665	179813	1023	Cerulenin	Cerulenin|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide	-	DRUGBANK	DB01034	C12H17NO3	small molecule	-	17397-89-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GVEZIHKRYBHEFX-NQQPLRFYSA-N
13025	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Flavin R (2010)	20373869	179810	1023	Cerulenin	Cerulenin|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide	-	DRUGBANK	DB01034	C12H17NO3	small molecule	-	17397-89-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GVEZIHKRYBHEFX-NQQPLRFYSA-N
13026	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Ronnett GV (2005)	15878185	179811	1023	Cerulenin	Cerulenin|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide	-	DRUGBANK	DB01034	C12H17NO3	small molecule	-	17397-89-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GVEZIHKRYBHEFX-NQQPLRFYSA-N
13027	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Li JN (2001)	11245456	179814	1023	Cerulenin	Cerulenin|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide|(2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide	-	DRUGBANK	DB01034	C12H17NO3	small molecule	-	17397-89-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GVEZIHKRYBHEFX-NQQPLRFYSA-N
13066	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Bora G (1968)	4887393	179838	1027	Carphenazine	Carphenazin|Carfenazine	-	DRUGBANK	DB01038	C23H29N3O2S	small molecule	-	2622-30-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DYCNETKPCXPXNW-UHFFFAOYSA-N
13067	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Platz AR (1967)	4861216	179839	1027	Carphenazine	Carphenazin|Carfenazine	-	DRUGBANK	DB01038	C23H29N3O2S	small molecule	-	2622-30-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DYCNETKPCXPXNW-UHFFFAOYSA-N
13068	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Vinar O (1967)	4889058	179840	1027	Carphenazine	Carphenazin|Carfenazine	-	DRUGBANK	DB01038	C23H29N3O2S	small molecule	-	2622-30-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DYCNETKPCXPXNW-UHFFFAOYSA-N
13107	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Blanpied TA (1997)	9120573	179867	1032	Memantine	3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine|Memantine|1-Amino-3,5-dimethyladamantane|Memantina|1,3-Dimethyl-5-adamantanamine|3,5-Dimethyl-1-aminoadamantane|Memantinum|3,5-Dimethyl-1-adamantanamine	act memantine|mematine hydroch	DRUGBANK	DB01043	C12H21N	small molecule	N06DX01|N06DA52|N06DA53	19982-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BUGYDGFZZOZRHP-UHFFFAOYSA-N
13108	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Chen HS (2005)	15901795	179866	1032	Memantine	3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine|Memantine|1-Amino-3,5-dimethyladamantane|Memantina|1,3-Dimethyl-5-adamantanamine|3,5-Dimethyl-1-aminoadamantane|Memantinum|3,5-Dimethyl-1-adamantanamine	act memantine|mematine hydroch	DRUGBANK	DB01043	C12H21N	small molecule	N06DX01|N06DA52|N06DA53	19982-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BUGYDGFZZOZRHP-UHFFFAOYSA-N
13109	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Maler JM (2005)	16009352	179865	1032	Memantine	3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine|Memantine|1-Amino-3,5-dimethyladamantane|Memantina|1,3-Dimethyl-5-adamantanamine|3,5-Dimethyl-1-aminoadamantane|Memantinum|3,5-Dimethyl-1-adamantanamine	act memantine|mematine hydroch	DRUGBANK	DB01043	C12H21N	small molecule	N06DX01|N06DA52|N06DA53	19982-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BUGYDGFZZOZRHP-UHFFFAOYSA-N
13110	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Rogawski MA (2003)	14530799	179868	1032	Memantine	3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine|Memantine|1-Amino-3,5-dimethyladamantane|Memantina|1,3-Dimethyl-5-adamantanamine|3,5-Dimethyl-1-aminoadamantane|Memantinum|3,5-Dimethyl-1-adamantanamine	act memantine|mematine hydroch	DRUGBANK	DB01043	C12H21N	small molecule	N06DX01|N06DA52|N06DA53	19982-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BUGYDGFZZOZRHP-UHFFFAOYSA-N
13111	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Bresink I (1996)	8886398	173224	1032	Memantine	3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine|Memantine|1-Amino-3,5-dimethyladamantane|Memantina|1,3-Dimethyl-5-adamantanamine|3,5-Dimethyl-1-aminoadamantane|Memantinum|3,5-Dimethyl-1-adamantanamine	act memantine|mematine hydroch	DRUGBANK	DB01043	C12H21N	small molecule	N06DX01|N06DA52|N06DA53	19982-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BUGYDGFZZOZRHP-UHFFFAOYSA-N
13161	108833	2559	-	GABRA6	-	9606	Homo sapiens	agonist	target	Korneyev AY (1996)	8786706	179892	1038	Ergoloid mesylate	Dihydroergotoxine Methanesulfonate|codergocrine mesylate|dihydroergotoxine monomethanesulfonate|Dihydroergotoxine Mesylate|co-dergocrine mesilate|dihydroergotoxine methanesulfonate|co-dergocrine mesylate|ergoloid methanesulfonate|Ergoloid Mesylates|co-dergocrine methanesulfonate|ergoloid methanesulfonates|Dihydroergotoxine Mesilate|codergocrine methanesulfonate|codergocrine mesilate|dihydrogenated ergot alkaloids|dihydroergotoxine methanesulfonates|hydrogenated ergot alkaloids	hydergine tablets, 1mg	DRUGBANK	DB01049	C30H41N5O8S	small molecule	C04AE51|C04AE01	8067-24-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FQHMMOGHDWAXDI-WUQHHHCFSA-N
13162	108833	2559	-	GABRA6	-	9606	Homo sapiens	agonist	target	Tvrdeic A (2003)	12955907	179898	1038	Ergoloid mesylate	Dihydroergotoxine Methanesulfonate|codergocrine mesylate|dihydroergotoxine monomethanesulfonate|Dihydroergotoxine Mesylate|co-dergocrine mesilate|dihydroergotoxine methanesulfonate|co-dergocrine mesylate|ergoloid methanesulfonate|Ergoloid Mesylates|co-dergocrine methanesulfonate|ergoloid methanesulfonates|Dihydroergotoxine Mesilate|codergocrine methanesulfonate|codergocrine mesilate|dihydrogenated ergot alkaloids|dihydroergotoxine methanesulfonates|hydrogenated ergot alkaloids	hydergine tablets, 1mg	DRUGBANK	DB01049	C30H41N5O8S	small molecule	C04AE51|C04AE01	8067-24-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FQHMMOGHDWAXDI-WUQHHHCFSA-N
13163	108833	2559	-	GABRA6	-	9606	Homo sapiens	agonist	target	Tvrdeic A (1991)	1664802	179897	1038	Ergoloid mesylate	Dihydroergotoxine Methanesulfonate|codergocrine mesylate|dihydroergotoxine monomethanesulfonate|Dihydroergotoxine Mesylate|co-dergocrine mesilate|dihydroergotoxine methanesulfonate|co-dergocrine mesylate|ergoloid methanesulfonate|Ergoloid Mesylates|co-dergocrine methanesulfonate|ergoloid methanesulfonates|Dihydroergotoxine Mesilate|codergocrine methanesulfonate|codergocrine mesilate|dihydrogenated ergot alkaloids|dihydroergotoxine methanesulfonates|hydrogenated ergot alkaloids	hydergine tablets, 1mg	DRUGBANK	DB01049	C30H41N5O8S	small molecule	C04AE51|C04AE01	8067-24-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FQHMMOGHDWAXDI-WUQHHHCFSA-N
13179	108835	2561	-	GABRB2	-	9606	Homo sapiens	agonist	target	Korneyev AY (1996)	8786706	179892	1038	Ergoloid mesylate	Dihydroergotoxine Methanesulfonate|codergocrine mesylate|dihydroergotoxine monomethanesulfonate|Dihydroergotoxine Mesylate|co-dergocrine mesilate|dihydroergotoxine methanesulfonate|co-dergocrine mesylate|ergoloid methanesulfonate|Ergoloid Mesylates|co-dergocrine methanesulfonate|ergoloid methanesulfonates|Dihydroergotoxine Mesilate|codergocrine methanesulfonate|codergocrine mesilate|dihydrogenated ergot alkaloids|dihydroergotoxine methanesulfonates|hydrogenated ergot alkaloids	hydergine tablets, 1mg	DRUGBANK	DB01049	C30H41N5O8S	small molecule	C04AE51|C04AE01	8067-24-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FQHMMOGHDWAXDI-WUQHHHCFSA-N
13180	108835	2561	-	GABRB2	-	9606	Homo sapiens	agonist	target	Tvrdeic A (2003)	12955907	179898	1038	Ergoloid mesylate	Dihydroergotoxine Methanesulfonate|codergocrine mesylate|dihydroergotoxine monomethanesulfonate|Dihydroergotoxine Mesylate|co-dergocrine mesilate|dihydroergotoxine methanesulfonate|co-dergocrine mesylate|ergoloid methanesulfonate|Ergoloid Mesylates|co-dergocrine methanesulfonate|ergoloid methanesulfonates|Dihydroergotoxine Mesilate|codergocrine methanesulfonate|codergocrine mesilate|dihydrogenated ergot alkaloids|dihydroergotoxine methanesulfonates|hydrogenated ergot alkaloids	hydergine tablets, 1mg	DRUGBANK	DB01049	C30H41N5O8S	small molecule	C04AE51|C04AE01	8067-24-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FQHMMOGHDWAXDI-WUQHHHCFSA-N
13181	108835	2561	-	GABRB2	-	9606	Homo sapiens	agonist	target	Tvrdeic A (1991)	1664802	179897	1038	Ergoloid mesylate	Dihydroergotoxine Methanesulfonate|codergocrine mesylate|dihydroergotoxine monomethanesulfonate|Dihydroergotoxine Mesylate|co-dergocrine mesilate|dihydroergotoxine methanesulfonate|co-dergocrine mesylate|ergoloid methanesulfonate|Ergoloid Mesylates|co-dergocrine methanesulfonate|ergoloid methanesulfonates|Dihydroergotoxine Mesilate|codergocrine methanesulfonate|codergocrine mesilate|dihydrogenated ergot alkaloids|dihydroergotoxine methanesulfonates|hydrogenated ergot alkaloids	hydergine tablets, 1mg	DRUGBANK	DB01049	C30H41N5O8S	small molecule	C04AE51|C04AE01	8067-24-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FQHMMOGHDWAXDI-WUQHHHCFSA-N
13296	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Peterson BZ (2006)	16675661	174772	1042	Nitrendipine	Deiten|Nidrel|Nitrendipino|Baypress|Bylotensin|Bayotensin|1,4-dihydro-2,6-Dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester|Nitrendipinum|BAY e 5009	-	DRUGBANK	DB01054	C18H20N2O6	small molecule	C08CA08|C09BB06	39562-70-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PVHUJELLJLJGLN-UHFFFAOYSA-N
13351	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15381832	179935	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13352	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Slomiany BL (2005)	15985706	179934	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13353	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15527548	179937	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13354	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Machida K (2005)	15618457	179936	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13355	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15110780	179938	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13411	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Moehler H (2002)	11752090	174537	1056	Clonazepam	5-(2-Chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one|1,3-dihydro-7-Nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one|CLONAZEPAM|5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one|5-(O-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one|Clonazepamum	pms-clonazepam tab 1.0mg|klono	DRUGBANK	DB01068	C15H10ClN3O3	small molecule	N03AE01	1622-61-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DGBIGWXXNGSACT-UHFFFAOYSA-N
13412	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	1056	Clonazepam	5-(2-Chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one|1,3-dihydro-7-Nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one|CLONAZEPAM|5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one|5-(O-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one|Clonazepamum	pms-clonazepam tab 1.0mg|klono	DRUGBANK	DB01068	C15H10ClN3O3	small molecule	N03AE01	1622-61-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DGBIGWXXNGSACT-UHFFFAOYSA-N
13423	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Moehler H (2002)	11752090	174537	1056	Clonazepam	5-(2-Chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one|1,3-dihydro-7-Nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one|CLONAZEPAM|5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one|5-(O-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one|Clonazepamum	pms-clonazepam tab 1.0mg|klono	DRUGBANK	DB01068	C15H10ClN3O3	small molecule	N03AE01	1622-61-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DGBIGWXXNGSACT-UHFFFAOYSA-N
13424	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	1056	Clonazepam	5-(2-Chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one|1,3-dihydro-7-Nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one|CLONAZEPAM|5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one|5-(O-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one|Clonazepamum	pms-clonazepam tab 1.0mg|klono	DRUGBANK	DB01068	C15H10ClN3O3	small molecule	N03AE01	1622-61-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DGBIGWXXNGSACT-UHFFFAOYSA-N
13593	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Purohit VC (2006)	16749788	180052	1071	Orlistat	(-)-Tetrahydrolipstatin|Xenical|Orlipastat|Orlipastatum|Tetrahydrolipstatin	xenical|xenical 120mg capsule|	DRUGBANK	DB01083	C29H53NO5	small molecule	A08AB01	96829-58-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AHLBNYSZXLDEJQ-FWEHEUNISA-N
13594	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Kremer L (2005)	16091048	180053	1071	Orlistat	(-)-Tetrahydrolipstatin|Xenical|Orlipastat|Orlipastatum|Tetrahydrolipstatin	xenical|xenical 120mg capsule|	DRUGBANK	DB01083	C29H53NO5	small molecule	A08AB01	96829-58-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AHLBNYSZXLDEJQ-FWEHEUNISA-N
13595	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Kridel SJ (2004)	15026345	180050	1071	Orlistat	(-)-Tetrahydrolipstatin|Xenical|Orlipastat|Orlipastatum|Tetrahydrolipstatin	xenical|xenical 120mg capsule|	DRUGBANK	DB01083	C29H53NO5	small molecule	A08AB01	96829-58-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AHLBNYSZXLDEJQ-FWEHEUNISA-N
13596	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Knowles LM (2004)	15138278	180051	1071	Orlistat	(-)-Tetrahydrolipstatin|Xenical|Orlipastat|Orlipastatum|Tetrahydrolipstatin	xenical|xenical 120mg capsule|	DRUGBANK	DB01083	C29H53NO5	small molecule	A08AB01	96829-58-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AHLBNYSZXLDEJQ-FWEHEUNISA-N
13597	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Menendez JA (2005)	15870086	180054	1071	Orlistat	(-)-Tetrahydrolipstatin|Xenical|Orlipastat|Orlipastatum|Tetrahydrolipstatin	xenical|xenical 120mg capsule|	DRUGBANK	DB01083	C29H53NO5	small molecule	A08AB01	96829-58-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AHLBNYSZXLDEJQ-FWEHEUNISA-N
13598	108488	2194	-	FASN	FAS|OA-519|SDR27X1	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	1071	Orlistat	(-)-Tetrahydrolipstatin|Xenical|Orlipastat|Orlipastatum|Tetrahydrolipstatin	xenical|xenical 120mg capsule|	DRUGBANK	DB01083	C29H53NO5	small molecule	A08AB01	96829-58-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AHLBNYSZXLDEJQ-FWEHEUNISA-N
13614	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	1074	Benzocaine	p-Ethoxycarboxylic Aniline|Benzocainum|Amben ethyl ester|4-aminobenzoic acid ethyl ester|p-Carbethoxyaniline|Ethyl Aminobenzoate|Ethyl p-Aminobenzoate|Ethyl p-Aminophenylcarboxylate|p-(Ethoxycarbonyl)aniline|Benzocaine|Benzocaina	insect bite relief|benzodent|v	DRUGBANK	DB01086	C9H11NO2	small molecule	R02AD01|D04AB04|N01BA05|C05AD03	94-09-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BLFLLBZGZJTVJG-UHFFFAOYSA-N
13615	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Hanck DA (2009)	19661462	180062	1074	Benzocaine	p-Ethoxycarboxylic Aniline|Benzocainum|Amben ethyl ester|4-aminobenzoic acid ethyl ester|p-Carbethoxyaniline|Ethyl Aminobenzoate|Ethyl p-Aminobenzoate|Ethyl p-Aminophenylcarboxylate|p-(Ethoxycarbonyl)aniline|Benzocaine|Benzocaina	insect bite relief|benzodent|v	DRUGBANK	DB01086	C9H11NO2	small molecule	R02AD01|D04AB04|N01BA05|C05AD03	94-09-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BLFLLBZGZJTVJG-UHFFFAOYSA-N
13616	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	1074	Benzocaine	p-Ethoxycarboxylic Aniline|Benzocainum|Amben ethyl ester|4-aminobenzoic acid ethyl ester|p-Carbethoxyaniline|Ethyl Aminobenzoate|Ethyl p-Aminobenzoate|Ethyl p-Aminophenylcarboxylate|p-(Ethoxycarbonyl)aniline|Benzocaine|Benzocaina	insect bite relief|benzodent|v	DRUGBANK	DB01086	C9H11NO2	small molecule	R02AD01|D04AB04|N01BA05|C05AD03	94-09-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BLFLLBZGZJTVJG-UHFFFAOYSA-N
13617	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Lipkind GM (2005)	16174788	176847	1074	Benzocaine	p-Ethoxycarboxylic Aniline|Benzocainum|Amben ethyl ester|4-aminobenzoic acid ethyl ester|p-Carbethoxyaniline|Ethyl Aminobenzoate|Ethyl p-Aminobenzoate|Ethyl p-Aminophenylcarboxylate|p-(Ethoxycarbonyl)aniline|Benzocaine|Benzocaina	insect bite relief|benzodent|v	DRUGBANK	DB01086	C9H11NO2	small molecule	R02AD01|D04AB04|N01BA05|C05AD03	94-09-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BLFLLBZGZJTVJG-UHFFFAOYSA-N
13618	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Ahern CA (2008)	17967784	180063	1074	Benzocaine	p-Ethoxycarboxylic Aniline|Benzocainum|Amben ethyl ester|4-aminobenzoic acid ethyl ester|p-Carbethoxyaniline|Ethyl Aminobenzoate|Ethyl p-Aminobenzoate|Ethyl p-Aminophenylcarboxylate|p-(Ethoxycarbonyl)aniline|Benzocaine|Benzocaina	insect bite relief|benzodent|v	DRUGBANK	DB01086	C9H11NO2	small molecule	R02AD01|D04AB04|N01BA05|C05AD03	94-09-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BLFLLBZGZJTVJG-UHFFFAOYSA-N
13908	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Peterson BZ (2006)	16675661	174772	1103	Nifedipine	Adalat|Nifedipine|4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester|Nifedipres|Nifecard|Nifedipino|Coracten|Nifecor|Procardia|Nifedipinum|Adapine	nifedipine|adalat xl plus|adal	DRUGBANK	DB01115	C17H18N2O6	small molecule	C08CA55|C08CA05|C08GA01	21829-25-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HYIMSNHJOBLJNT-UHFFFAOYSA-N
14337	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Perouansky M (1996)	8968191	180413	1147	Halothane	Rhodialothan|1-Bromo-1-chloro-2,2,2-trifluoroethane|Bromochlorotrifluoroethane|Halothane|Narcotane|Halothanum|Fluothane|1,1,1-Trifluoro-2-chloro-2-bromoethane|Phthorothanum|Halotano|2,2,2-Trifluoro-1-chloro-1-bromoethane|1,1,1-Trifluoro-2-bromo-2-chloroethane|Ftorotan|2-Bromo-2-Chloro-1,1,1-Trifluoroethane	fluothane liq inh 1000mg/gm|ha	DRUGBANK	DB01159	C2HBrClF3	small molecule	N01AB01	151-67-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCQZXOMGPXTTIC-UHFFFAOYSA-N
14364	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Imming P (2006)	17016423	171742	1149	Chloroprocaine	Chloroprocaine|Chlorprocaine|2-Chloroprocaine|Chloroprocain|Cloroprocaina|4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester|Chloroprocainum	chloroprocaine hydrochloride|n	DRUGBANK	DB01161	C13H19ClN2O2	small molecule	N01BA04	133-16-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VDANGULDQQJODZ-UHFFFAOYSA-N
14365	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Wong K (1993)	8418714	180421	1149	Chloroprocaine	Chloroprocaine|Chlorprocaine|2-Chloroprocaine|Chloroprocain|Cloroprocaina|4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester|Chloroprocainum	chloroprocaine hydrochloride|n	DRUGBANK	DB01161	C13H19ClN2O2	small molecule	N01BA04	133-16-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VDANGULDQQJODZ-UHFFFAOYSA-N
14366	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Overington JP (2006)	17139284	171741	1149	Chloroprocaine	Chloroprocaine|Chlorprocaine|2-Chloroprocaine|Chloroprocain|Cloroprocaina|4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester|Chloroprocainum	chloroprocaine hydrochloride|n	DRUGBANK	DB01161	C13H19ClN2O2	small molecule	N01BA04	133-16-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VDANGULDQQJODZ-UHFFFAOYSA-N
14449	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	inhibitor	target	Pubill D (1999)	10344632	180467	1161	Orphenadrine	o-methyldiphenhydramine|o-monomethyldiphenhydramine|Orfenadrina|2-methyldiphenhydramine|ORPHENADRINE|Dimethyl-[2-(phenyl-O-tolyl-methoxy)-ethyl]-amine|N,N-Dimethyl-2-[(O-methyl-alpha-phenylbenzyl)oxy]ethylamine|Orphenadrinum|beta-Dimethylaminoethyl 2-methylbenzhydryl ether|2-(phenyl-o-tolylmethoxy)ethyldimethylamine|N,N-Dimethyl-2-(phenyl(O-tolyl)methoxy)ethanamine|-dimethylaminoethyl 2-methylbenzhydryl ether|Phenyl-O-tolylmethyl dimethyaminoethyl ether|N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine	norgesic forte|orphenadrine ci	DRUGBANK	DB01173	C18H23NO	small molecule	M03BC51|N04AB02|M03BC01	83-98-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QVYRGXJJSLMXQH-UHFFFAOYSA-N
14475	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Daniell LC (1994)	7862741	175103	1162	Phenobarbital	Phenobarbitol|5-Phenyl-5-ethylbarbituric acid|PHENYLETHYLMALONYLUREA|5-Ethyl-5-phenyl-pyrimidine-2,4,6-trione|Phenobarbitone|Luminal|5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Phenobarbital|Phenylaethylbarbitursaeure|5-Ethyl-5-phenylbarbituric acid|Phenylethylbarbituric Acid|Phenylethylbarbiturate|Phenobarbituric Acid|5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione|Phenylethylbarbitursaeure	phenobarbital sodium injection	DRUGBANK	DB01174	C12H12N2O3	small molecule	N03AA02	50-06-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DDBREPKUVSBGFI-UHFFFAOYSA-N
14599	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Kvernmo T (2008)	18691132	174662	1174	Pergolide	Pergolide Methanesulfonate|Pergolidum|Pergolide Mesylate|Pergolida	permax tab 0.25mg|permax tab 0	DRUGBANK	DB01186	C19H26N2S	small molecule	N04BC02	66104-22-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YEHCICAEULNIGD-MZMPZRCHSA-N
14632	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Moehler H (2002)	11752090	174537	1177	Desflurane	(+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether|Desflurano|Desflurane|Suprane|1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane|Desfluranum|Difluoromethyl 1,2,2,2-tetrafluoroethyl ether	desflurane|suprane	DRUGBANK	DB01189	C3H2F6O	small molecule	N01AB07	57041-67-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DPYMFVXJLLWWEU-UHFFFAOYSA-N
14633	108833	2559	-	GABRA6	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	1177	Desflurane	(+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether|Desflurano|Desflurane|Suprane|1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane|Desfluranum|Difluoromethyl 1,2,2,2-tetrafluoroethyl ether	desflurane|suprane	DRUGBANK	DB01189	C3H2F6O	small molecule	N01AB07	57041-67-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DPYMFVXJLLWWEU-UHFFFAOYSA-N
14644	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Moehler H (2002)	11752090	174537	1177	Desflurane	(+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether|Desflurano|Desflurane|Suprane|1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane|Desfluranum|Difluoromethyl 1,2,2,2-tetrafluoroethyl ether	desflurane|suprane	DRUGBANK	DB01189	C3H2F6O	small molecule	N01AB07	57041-67-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DPYMFVXJLLWWEU-UHFFFAOYSA-N
14645	108835	2561	-	GABRB2	-	9606	Homo sapiens	positive allosteric modulator	target	Riss J (2008)	18384456	174202	1177	Desflurane	(+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether|Desflurano|Desflurane|Suprane|1,1,1,2-Tetrafluoro-2-(difluoromethoxy)ethane|Desfluranum|Difluoromethyl 1,2,2,2-tetrafluoroethyl ether	desflurane|suprane	DRUGBANK	DB01189	C3H2F6O	small molecule	N01AB07	57041-67-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DPYMFVXJLLWWEU-UHFFFAOYSA-N
14800	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Kvernmo T (2008)	18691132	174662	1188	Bromocriptine	2-Bromo-alpha-ergokryptine|(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione|2-bromo--ergocryptine|Bromocryptine|2-Bromo-alpha-ergocryptine|2-bromo--ergokryptin|Bromocriptinum|2-bromo--ergokryptine|Bromoergocriptine|(5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman|(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman|2-Bromo-alpha-ergokryptin|Bromocriptina|Bromoergocryptine	syn-bromocriptine cap 5mg|co b	DRUGBANK	DB01200	C32H40BrN5O5	small molecule	G02CB01|N04BC01	25614-03-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OZVBMTJYIDMWIL-AYFBDAFISA-N
14920	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Miller LG (1987)	2889803	180661	1203	Estazolam	Estazolamum|8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine	prosom tab 2mg|prosom tab 1mg|	DRUGBANK	DB01215	C16H11ClN4	small molecule	N05CD04	29975-16-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CDCHDCWJMGXXRH-UHFFFAOYSA-N
14921	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Braestrup C (1978)	639854	180662	1203	Estazolam	Estazolamum|8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine	prosom tab 2mg|prosom tab 1mg|	DRUGBANK	DB01215	C16H11ClN4	small molecule	N05CD04	29975-16-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CDCHDCWJMGXXRH-UHFFFAOYSA-N
15078	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Nasrallah HA (2008)	17848919	174616	1212	Quetiapine	Quetiapine hemifumarate|2-[2-(4-Dibenzo[b,F][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol|Quetiapine|Quetiapina|Quetiapinum|Quetiapine fumarate	sandoz quetiapine|quetiapine f	DRUGBANK	DB01224	C21H25N3O2S	small molecule	N05AH04	111974-69-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	URKOMYMAXPYINW-UHFFFAOYSA-N
15179	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Koller WC (1998)	9633680	180775	1223	Levodopa	3-Hydroxy-L-tyrosine|(-)-3-(3,4-Dihydroxyphenyl)-L-alanine|L-beta-(3,4-Dihydroxyphenyl)alanine|3,4-Dihydroxy-L-phenylalanine|Dopar|()-3-(3,4-dihydroxyphenyl)-L-alanine|Dihydroxy-L-phenylalanine|(-)-Dopa|Levodopum|Levodopa|L-3,4-dihydroxyphenylalanine|3,4-DIHYDROXYPHENYLALANINE|L-DOPA|beta-(3,4-Dihydroxyphenyl)alanine|-(3,4-dihydroxyphenyl)alanine|beta-(3,4-Dihydroxyphenyl)-L-alanine|()-dopa	sinemet 100/25|sinemet 250/25|	DRUGBANK	DB01235	C9H11NO4	small molecule	N04BA02|N04BA03|N04BA01	59-92-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WTDRDQBEARUVNC-LURJTMIESA-N
15180	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Deleu D (2002)	11978145	179837	1223	Levodopa	3-Hydroxy-L-tyrosine|(-)-3-(3,4-Dihydroxyphenyl)-L-alanine|L-beta-(3,4-Dihydroxyphenyl)alanine|3,4-Dihydroxy-L-phenylalanine|Dopar|()-3-(3,4-dihydroxyphenyl)-L-alanine|Dihydroxy-L-phenylalanine|(-)-Dopa|Levodopum|Levodopa|L-3,4-dihydroxyphenylalanine|3,4-DIHYDROXYPHENYLALANINE|L-DOPA|beta-(3,4-Dihydroxyphenyl)alanine|-(3,4-dihydroxyphenyl)alanine|beta-(3,4-Dihydroxyphenyl)-L-alanine|()-dopa	sinemet 100/25|sinemet 250/25|	DRUGBANK	DB01235	C9H11NO4	small molecule	N04BA02|N04BA03|N04BA01	59-92-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WTDRDQBEARUVNC-LURJTMIESA-N
15181	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Onofrj M (2008)	18549347	180774	1223	Levodopa	3-Hydroxy-L-tyrosine|(-)-3-(3,4-Dihydroxyphenyl)-L-alanine|L-beta-(3,4-Dihydroxyphenyl)alanine|3,4-Dihydroxy-L-phenylalanine|Dopar|()-3-(3,4-dihydroxyphenyl)-L-alanine|Dihydroxy-L-phenylalanine|(-)-Dopa|Levodopum|Levodopa|L-3,4-dihydroxyphenylalanine|3,4-DIHYDROXYPHENYLALANINE|L-DOPA|beta-(3,4-Dihydroxyphenyl)alanine|-(3,4-dihydroxyphenyl)alanine|beta-(3,4-Dihydroxyphenyl)-L-alanine|()-dopa	sinemet 100/25|sinemet 250/25|	DRUGBANK	DB01235	C9H11NO4	small molecule	N04BA02|N04BA03|N04BA01	59-92-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WTDRDQBEARUVNC-LURJTMIESA-N
15263	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	partial agonist	target	Nasrallah HA (2008)	17848919	174616	1226	Aripiprazole	OPC 31|Abilify|Abilitat|Aripiprazol|Aripiprazole|Aripiprazolum	aristada|aripiprazole oral sol	DRUGBANK	DB01238	C23H27Cl2N3O2	small molecule	N05AX12	129722-12-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CEUORZQYGODEFX-UHFFFAOYSA-N
15264	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Nasrallah HA (2008)	17848919	174616	1226	Aripiprazole	OPC 31|Abilify|Abilitat|Aripiprazol|Aripiprazole|Aripiprazolum	aristada|aripiprazole oral sol	DRUGBANK	DB01238	C23H27Cl2N3O2	small molecule	N05AX12	129722-12-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CEUORZQYGODEFX-UHFFFAOYSA-N
15412	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Schittenhelm MM (2006)	16397263	180858	1242	Dasatinib	Dasatinib (anh.)|Dasatinib|N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide|BMS dasatinib|Anhydrous dasatinib|dasatinib (anhydrous)|anh. dasatinib|Dasatinibum|BDBM13216	sprycel	DRUGBANK	DB01254	C22H26ClN7O2S	small molecule	L01XE06	302962-49-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZBNZXTGUTAYRHI-UHFFFAOYSA-N
15413	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Dizdar O (2008)	17351742	180865	1242	Dasatinib	Dasatinib (anh.)|Dasatinib|N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide|BMS dasatinib|Anhydrous dasatinib|dasatinib (anhydrous)|anh. dasatinib|Dasatinibum|BDBM13216	sprycel	DRUGBANK	DB01254	C22H26ClN7O2S	small molecule	L01XE06	302962-49-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZBNZXTGUTAYRHI-UHFFFAOYSA-N
15414	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Shah NP (2006)	16434489	180864	1242	Dasatinib	Dasatinib (anh.)|Dasatinib|N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide|BMS dasatinib|Anhydrous dasatinib|dasatinib (anhydrous)|anh. dasatinib|Dasatinibum|BDBM13216	sprycel	DRUGBANK	DB01254	C22H26ClN7O2S	small molecule	L01XE06	302962-49-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZBNZXTGUTAYRHI-UHFFFAOYSA-N
15446	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Zhou H (2004)	14751502	180891	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15447	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Burris HA (2004)	15163842	180890	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15448	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Xia W (2004)	14737100	180889	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15449	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Vazquez-Martin A (2011)	20658522	180888	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15450	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Grana TM (2003)	14633707	180885	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15451	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Wood ER (2004)	15374980	180884	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15452	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Johnston SR (2006)	16894399	180887	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15453	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Xia W (2002)	12214266	180886	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15454	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Langer CJ (2004)	14967461	180881	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15455	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15456	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Tevaarwerk AJ (2010)	20110044	180883	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15457	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Medina PJ (2008)	18803986	180882	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15458	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Zhou H (2004)	14751502	180891	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15459	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Burris HA (2004)	15163842	180890	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15460	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Xia W (2004)	14737100	180889	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15461	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Vazquez-Martin A (2011)	20658522	180888	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15462	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Grana TM (2003)	14633707	180885	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15463	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Wood ER (2004)	15374980	180884	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15464	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Johnston SR (2006)	16894399	180887	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15465	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Xia W (2002)	12214266	180886	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15466	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Langer CJ (2004)	14967461	180881	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15467	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Chen X (2002)	11752352	171740	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15468	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Tevaarwerk AJ (2010)	20110044	180883	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15469	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antagonist	target	Medina PJ (2008)	18803986	180882	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BCFGMOOMADDAQU-UHFFFAOYSA-N
15594	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Heymach JV (2006)	16857825	180948	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15595	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Cohen RB (2003)	12620146	180949	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15596	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Chen X (2002)	11752352	171740	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15597	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Foon KA (2004)	14967460	180947	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15598	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Keating GM (2010)	20481659	180957	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15599	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Yang XD (2001)	11255078	180956	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15600	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Segaert S (2005)	16012181	180955	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15601	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Lynch DH (2002)	11894013	180954	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15602	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Saadeh CE (2007)	17355997	180953	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15603	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Wu M (2008)	18343240	180952	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15604	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Jean GW (2008)	18503402	180951	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15605	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	suppressor	target	Keating GM (2010)	20623992	180950	1256	Panitumumab	ABX-EGF	vectibix	DRUGBANK	DB01269	-	biologic	L01XC08	339177-26-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15679	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Roth JD (2009)	19273748	181015	1265	Pramlintide	-	symlinpen	DRUGBANK	DB01278	C171H267N51O53S2	biologic	A10BX05	151126-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15680	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Qi T (2008)	18593822	181014	1265	Pramlintide	-	symlinpen	DRUGBANK	DB01278	C171H267N51O53S2	biologic	A10BX05	151126-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15681	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Lutz TA (2010)	20357016	181011	1265	Pramlintide	-	symlinpen	DRUGBANK	DB01278	C171H267N51O53S2	biologic	A10BX05	151126-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15682	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Qi T (2010)	20015292	181010	1265	Pramlintide	-	symlinpen	DRUGBANK	DB01278	C171H267N51O53S2	biologic	A10BX05	151126-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15683	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Nyholm B (2001)	11772274	181013	1265	Pramlintide	-	symlinpen	DRUGBANK	DB01278	C171H267N51O53S2	biologic	A10BX05	151126-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15684	107250	799	-	CALCR	CRT|CT-R|CTR|CTR1	9606	Homo sapiens	agonist	target	Hay DL (2004)	15494035	181012	1265	Pramlintide	-	symlinpen	DRUGBANK	DB01278	C171H267N51O53S2	biologic	A10BX05	151126-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15978	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	1315	Amobarbital	5-Ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-isopentylbarbituric acid|Amylobarbitone|Barbamyl|5-Ethyl-5-isoamylbarbituric acid|Amobarbital|Amytal|5-Ethyl-5-(3-methylbutyl)barbituric acid|Barbamil	amytal sodium pulvule 222 0.2g	DRUGBANK	DB01351	C11H18N2O3	small molecule	N05CA02	57-43-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VIROVYVQCGLCII-UHFFFAOYSA-N
15979	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	1315	Amobarbital	5-Ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione|5-Ethyl-5-isopentylbarbituric acid|Amylobarbitone|Barbamyl|5-Ethyl-5-isoamylbarbituric acid|Amobarbital|Amytal|5-Ethyl-5-(3-methylbutyl)barbituric acid|Barbamil	amytal sodium pulvule 222 0.2g	DRUGBANK	DB01351	C11H18N2O3	small molecule	N05CA02	57-43-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VIROVYVQCGLCII-UHFFFAOYSA-N
16001	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	1316	Aprobarbital	5-Allyl-5-isopropylbarbituric acid|Alurate|5-Allyl-5-isopropylpyrimidine-2,4,6(1H,3H,5H)-trione|5-Isopropyl-5-allylbarbituric acid|Aprobarbital|Allypropymal|5-(1-Methylethyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione	-	DRUGBANK	DB01352	C10H14N2O3	small molecule	N05CA05	77-02-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UORJNBVJVRLXMQ-UHFFFAOYSA-N
16002	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	1316	Aprobarbital	5-Allyl-5-isopropylbarbituric acid|Alurate|5-Allyl-5-isopropylpyrimidine-2,4,6(1H,3H,5H)-trione|5-Isopropyl-5-allylbarbituric acid|Aprobarbital|Allypropymal|5-(1-Methylethyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione	-	DRUGBANK	DB01352	C10H14N2O3	small molecule	N05CA05	77-02-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UORJNBVJVRLXMQ-UHFFFAOYSA-N
16027	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	1317	Butethal	Butobarbitone|Butobarbital|Butethal|Neonal	-	DRUGBANK	DB01353	C10H16N2O3	small molecule	N05CA03	77-28-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	STDBAQMTJLUMFW-UHFFFAOYSA-N
16028	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	1317	Butethal	Butobarbitone|Butobarbital|Butethal|Neonal	-	DRUGBANK	DB01353	C10H16N2O3	small molecule	N05CA03	77-28-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	STDBAQMTJLUMFW-UHFFFAOYSA-N
16050	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	1318	Heptabarbital	Heptabarbital|Heptabarbum|Medapan|Heptamal|Heptabarbitone|Medomine|Heptbarbital|Heptabarb|Heptamalum|Heptadorm	-	DRUGBANK	DB01354	C13H18N2O3	small molecule	N05CA11	509-86-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PAZQYDJGLKSCSI-UHFFFAOYSA-N
16051	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	1318	Heptabarbital	Heptabarbital|Heptabarbum|Medapan|Heptamal|Heptabarbitone|Medomine|Heptbarbital|Heptabarb|Heptamalum|Heptadorm	-	DRUGBANK	DB01354	C13H18N2O3	small molecule	N05CA11	509-86-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PAZQYDJGLKSCSI-UHFFFAOYSA-N
16077	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	1319	Hexobarbital	5-Cyclohex-1-enyl-1,5-dimethyl-pyrimidine-2,4,6-trione|Evipan|Hexobarbital|5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid|Hexobarbitone|5-(1-Cyclohexen-1-yl)-1,5-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Methylhexabital|Methexenyl	-	DRUGBANK	DB01355	C12H16N2O3	small molecule	N05CA16|N01AF02	56-29-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UYXAWHWODHRRMR-UHFFFAOYSA-N
16078	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	1319	Hexobarbital	5-Cyclohex-1-enyl-1,5-dimethyl-pyrimidine-2,4,6-trione|Evipan|Hexobarbital|5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid|Hexobarbitone|5-(1-Cyclohexen-1-yl)-1,5-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione|Methylhexabital|Methexenyl	-	DRUGBANK	DB01355	C12H16N2O3	small molecule	N05CA16|N01AF02	56-29-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UYXAWHWODHRRMR-UHFFFAOYSA-N
16264	108835	2561	-	GABRB2	-	9606	Homo sapiens	negative modulator	target	Hanrahan JR (2003)	12824018	181231	1337	Ginkgo biloba	Japanese Silver Apricot|Pei Go Su Ye|Yinhsing|Bai Guo Ye|Baiguo|Salisburia Adiantifolia|Maidenhair Tree|Fossil Tree|Yen Xing|Herba Ginkgo Biloba|Adiantifolia|Ginkgo Folium|Kew Tree	-	DRUGBANK	DB01381	-	small molecule	N06DX02|N06DA53	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
16304	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Mocanu MM (1999)	10372226	181239	1340	Mibefradil	-	-	DRUGBANK	DB01388	C29H38FN3O3	small molecule	C08CX01	116644-53-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HBNPJJILLOYFJU-VMPREFPWSA-N
16305	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Jimenez C (2000)	10665814	181238	1340	Mibefradil	-	-	DRUGBANK	DB01388	C29H38FN3O3	small molecule	C08CX01	116644-53-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HBNPJJILLOYFJU-VMPREFPWSA-N
16306	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Lee TS (2006)	16899990	180228	1340	Mibefradil	-	-	DRUGBANK	DB01388	C29H38FN3O3	small molecule	C08CX01	116644-53-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HBNPJJILLOYFJU-VMPREFPWSA-N
16480	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Green B (2004)	15701205	181306	1352	Methotrimeprazine	(-)-(2R)-3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine|Methotrimeprazine|2-Methoxytrimeprazine|(-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine|Levomepromazine|Levomepromazina|Levomepromazinum	riva-meprazine 5mg tablets|riv	DRUGBANK	DB01403	C19H24N2OS	small molecule	N05AA02	60-99-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VRQVVMDWGGWHTJ-CQSZACIVSA-N
16796	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	1429	Barbital	-	-	DRUGBANK	DB01483	C8H12N2O3	small molecule	N05CA04	57-44-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FTOAOBMCPZCFFF-UHFFFAOYSA-N
16797	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	1429	Barbital	-	-	DRUGBANK	DB01483	C8H12N2O3	small molecule	N05CA04	57-44-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FTOAOBMCPZCFFF-UHFFFAOYSA-N
16826	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Mehta AK (1999)	10209232	174569	1441	Barbituric acid derivative	-	-	DRUGBANK	DB01496	C16H11F3N2O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DNZPLHRZXUJATK-UHFFFAOYSA-N
16827	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Yamakura T (2001)	11264449	174568	1441	Barbituric acid derivative	-	-	DRUGBANK	DB01496	C16H11F3N2O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DNZPLHRZXUJATK-UHFFFAOYSA-N
16867	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Stirling JM (1989)	2538766	181476	1460	Tenocyclidine	TCP	-	DRUGBANK	DB01520	C15H23NS	small molecule	-	21500-98-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JUZZEWSCNBCFRL-UHFFFAOYSA-N
16868	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Geldenhuys WJ (2007)	17157509	181478	1460	Tenocyclidine	TCP	-	DRUGBANK	DB01520	C15H23NS	small molecule	-	21500-98-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JUZZEWSCNBCFRL-UHFFFAOYSA-N
16900	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Santhakumar V (2006)	16554486	181490	1484	Flunitrazepam	Flunitrazepamum|Rohypnol	-	DRUGBANK	DB01544	C16H12FN3O3	small molecule	N05CD03	1622-62-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PPTYJKAXVCCBDU-UHFFFAOYSA-N
16901	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	You H (2010)	20638393	181489	1484	Flunitrazepam	Flunitrazepamum|Rohypnol	-	DRUGBANK	DB01544	C16H12FN3O3	small molecule	N05CD03	1622-62-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PPTYJKAXVCCBDU-UHFFFAOYSA-N
16902	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Skilbeck KJ (2008)	17976880	181487	1484	Flunitrazepam	Flunitrazepamum|Rohypnol	-	DRUGBANK	DB01544	C16H12FN3O3	small molecule	N05CD03	1622-62-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PPTYJKAXVCCBDU-UHFFFAOYSA-N
16936	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	1498	Bromazepam	Bromazepamum|Lectopam	alti-bromazepam 1.5mg tablets|	DRUGBANK	DB01558	C14H10BrN3O	small molecule	N05BA08	1812-30-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VMIYHDSEFNYJSL-UHFFFAOYSA-N
16940	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	1498	Bromazepam	Bromazepamum|Lectopam	alti-bromazepam 1.5mg tablets|	DRUGBANK	DB01558	C14H10BrN3O	small molecule	N05BA08	1812-30-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VMIYHDSEFNYJSL-UHFFFAOYSA-N
16956	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Baburin I (2008)	18604239	181509	1499	Clotiazepam	Clotiazepamum|Rize	-	DRUGBANK	DB01559	C16H15ClN2OS	small molecule	N05BA21	33671-46-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CHBRHODLKOZEPZ-UHFFFAOYSA-N
17001	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Nakatsuka I (1985)	2857046	181520	1507	Fludiazepam	Erispan|Fludiazepamum|7-chloro-5-(O-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one	-	DRUGBANK	DB01567	C16H12ClFN2O	small molecule	N05BA17	3900-31-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ROYOYTLGDLIGBX-UHFFFAOYSA-N
17153	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Schove LT (1994)	7773620	181550	1527	Prazepam	Centrax|Prazepamum	-	DRUGBANK	DB01588	C19H17ClN2O	small molecule	N05BA11	2955-38-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MWQCHHACWWAQLJ-UHFFFAOYSA-N
17226	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Walash MI (1994)	7849137	181561	1533	Cinolazepam	7-chloro-5-(O-Fluorophenyl)-2,3-dihydro-3-hydroxy-2-oxo-1H-1,4-benzodiazepine-1-propionitrile|Cinolazepamum|7-chloro-5-(2-Fluorophenyl)-2,3-dihydro-3-hydroxy-2-oxo-1H-1,4-benzodiazepine-1-propanenitrile|1-(2-Cyanoethyl)-7-chloro-3-hydroxy-5-(2'-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one	-	DRUGBANK	DB01594	C18H13ClFN3O2	small molecule	N05CD13	75696-02-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XAXMYHMKTCNRRZ-UHFFFAOYSA-N
17244	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	1534	Nitrazepam	Paxisyn|7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one|Somitran|Nelbon|Sonebon|Gerson|Calsmin|Benzalin|Unisomnia|Relact|Radedorm|Trazenin|Neozepam|Hipnax|Persopit|Ibrovek|Surem|2,3-dihydro-7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2-one|Eatan|Eunoctin|Ro 5-3059|Nitrazepamum|Neuchlonic|Ro 4-5360|Mogadon|Imesont|Sonnolin|N-Desmethylnimetazepam|Pelson|Apodorm|1,3-dihydro-7-Nitro-5-phenyl-2H-1,4-benzodiazepin-2-one|Hipsal|Nelmat|Atempol|Nitrados|7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one|Remnos|Imeson	sandoz nitrazepam|nitrazepam-1	DRUGBANK	DB01595	C15H11N3O3	small molecule	N05CD02	146-22-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KJONHKAYOJNZEC-UHFFFAOYSA-N
17245	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	1534	Nitrazepam	Paxisyn|7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one|Somitran|Nelbon|Sonebon|Gerson|Calsmin|Benzalin|Unisomnia|Relact|Radedorm|Trazenin|Neozepam|Hipnax|Persopit|Ibrovek|Surem|2,3-dihydro-7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2-one|Eatan|Eunoctin|Ro 5-3059|Nitrazepamum|Neuchlonic|Ro 4-5360|Mogadon|Imesont|Sonnolin|N-Desmethylnimetazepam|Pelson|Apodorm|1,3-dihydro-7-Nitro-5-phenyl-2H-1,4-benzodiazepin-2-one|Hipsal|Nelmat|Atempol|Nitrados|7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one|Remnos|Imeson	sandoz nitrazepam|nitrazepam-1	DRUGBANK	DB01595	C15H11N3O3	small molecule	N05CD02	146-22-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KJONHKAYOJNZEC-UHFFFAOYSA-N
17255	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Moehler H (2002)	11752090	174537	1534	Nitrazepam	Paxisyn|7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one|Somitran|Nelbon|Sonebon|Gerson|Calsmin|Benzalin|Unisomnia|Relact|Radedorm|Trazenin|Neozepam|Hipnax|Persopit|Ibrovek|Surem|2,3-dihydro-7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2-one|Eatan|Eunoctin|Ro 5-3059|Nitrazepamum|Neuchlonic|Ro 4-5360|Mogadon|Imesont|Sonnolin|N-Desmethylnimetazepam|Pelson|Apodorm|1,3-dihydro-7-Nitro-5-phenyl-2H-1,4-benzodiazepin-2-one|Hipsal|Nelmat|Atempol|Nitrados|7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one|Remnos|Imeson	sandoz nitrazepam|nitrazepam-1	DRUGBANK	DB01595	C15H11N3O3	small molecule	N05CD02	146-22-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KJONHKAYOJNZEC-UHFFFAOYSA-N
17256	108833	2559	-	GABRA6	-	9606	Homo sapiens	potentiator	target	Riss J (2008)	18384456	174202	1534	Nitrazepam	Paxisyn|7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one|Somitran|Nelbon|Sonebon|Gerson|Calsmin|Benzalin|Unisomnia|Relact|Radedorm|Trazenin|Neozepam|Hipnax|Persopit|Ibrovek|Surem|2,3-dihydro-7-Nitro-5-phenyl-1H-1,4-benzodiazepin-2-one|Eatan|Eunoctin|Ro 5-3059|Nitrazepamum|Neuchlonic|Ro 4-5360|Mogadon|Imesont|Sonnolin|N-Desmethylnimetazepam|Pelson|Apodorm|1,3-dihydro-7-Nitro-5-phenyl-2H-1,4-benzodiazepin-2-one|Hipsal|Nelmat|Atempol|Nitrados|7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one|Remnos|Imeson	sandoz nitrazepam|nitrazepam-1	DRUGBANK	DB01595	C15H11N3O3	small molecule	N05CD02	146-22-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KJONHKAYOJNZEC-UHFFFAOYSA-N
17423	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Manzaneque JM (1999)	10222441	181604	1561	Zuclopenthixol	Zuclopentixol|Zuclopenthixolum|cis-Clopenthixol	clopixol tablets 25mg|clopixol	DRUGBANK	DB01624	C22H25ClN2OS	small molecule	N05AF05	53772-83-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WFPIAZLQTJBIFN-DVZOWYKESA-N
17424	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	antagonist	target	Lublin H (1991)	1822319	181605	1561	Zuclopenthixol	Zuclopentixol|Zuclopenthixolum|cis-Clopenthixol	clopixol tablets 25mg|clopixol	DRUGBANK	DB01624	C22H25ClN2OS	small molecule	N05AF05	53772-83-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WFPIAZLQTJBIFN-DVZOWYKESA-N
17603	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	agonist	target	Compagnone NA (1998)	9539798	181620	1643	Prasterone	Dehydroandrosterone|3-hydroxyandrost-5-en-17-one|Dehydroepiandrosterone|Dehydroisoandrosterone|5-dehydroepiandrosterone|3beta-hydroxyandrost-5-en-17-one|3-beta-Hydroxy-5-androsten-17-one|5-DHEA|DHEA	prastera	DRUGBANK	DB01708	C19H28O2	small molecule	A14AA07|G03EA03	53-43-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FMGSKLZLMKYGDP-USOAJAOKSA-N
17615	108833	2559	-	GABRA6	-	9606	Homo sapiens	antagonist	target	Sousa A (1997)	9262347	181622	1643	Prasterone	Dehydroandrosterone|3-hydroxyandrost-5-en-17-one|Dehydroepiandrosterone|Dehydroisoandrosterone|5-dehydroepiandrosterone|3beta-hydroxyandrost-5-en-17-one|3-beta-Hydroxy-5-androsten-17-one|5-DHEA|DHEA	prastera	DRUGBANK	DB01708	C19H28O2	small molecule	A14AA07|G03EA03	53-43-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FMGSKLZLMKYGDP-USOAJAOKSA-N
17621	108835	2561	-	GABRB2	-	9606	Homo sapiens	antagonist	target	Sousa A (1997)	9262347	181622	1643	Prasterone	Dehydroandrosterone|3-hydroxyandrost-5-en-17-one|Dehydroepiandrosterone|Dehydroisoandrosterone|5-dehydroepiandrosterone|3beta-hydroxyandrost-5-en-17-one|3-beta-Hydroxy-5-androsten-17-one|5-DHEA|DHEA	prastera	DRUGBANK	DB01708	C19H28O2	small molecule	A14AA07|G03EA03	53-43-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FMGSKLZLMKYGDP-USOAJAOKSA-N
17667	109643	3417	-	IDH1	HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1662	Isocitric Acid	-	-	DRUGBANK	DB01727	C6H8O7	small molecule	-	320-77-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ODBLHEXUDAPZAU-OKKQSCSOSA-N
17668	109643	3417	-	IDH1	HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1662	Isocitric Acid	-	-	DRUGBANK	DB01727	C6H8O7	small molecule	-	320-77-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ODBLHEXUDAPZAU-OKKQSCSOSA-N
17822	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1741	3h-Indole-5,6-Diol	-	-	DRUGBANK	DB01811	C8H6NO2	small molecule	-	3131-52-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
17823	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1741	3h-Indole-5,6-Diol	-	-	DRUGBANK	DB01811	C8H6NO2	small molecule	-	3131-52-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
17824	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1741	3h-Indole-5,6-Diol	-	-	DRUGBANK	DB01811	C8H6NO2	small molecule	-	3131-52-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
17927	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1774	Dimethylformamide	-	-	DRUGBANK	DB01844	C3H7NO	small molecule	-	68-12-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZMXDDKWLCZADIW-UHFFFAOYSA-N
17928	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1774	Dimethylformamide	-	-	DRUGBANK	DB01844	C3H7NO	small molecule	-	68-12-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZMXDDKWLCZADIW-UHFFFAOYSA-N
17929	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1774	Dimethylformamide	-	-	DRUGBANK	DB01844	C3H7NO	small molecule	-	68-12-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZMXDDKWLCZADIW-UHFFFAOYSA-N
18183	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1886	Phosphonotyrosine	-	-	DRUGBANK	DB01962	C9H12NO6P	small molecule	-	21820-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DCWXELXMIBXGTH-QMMMGPOBSA-N
18184	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1886	Phosphonotyrosine	-	-	DRUGBANK	DB01962	C9H12NO6P	small molecule	-	21820-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DCWXELXMIBXGTH-QMMMGPOBSA-N
18284	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1920	3-Methylpyridine	-	-	DRUGBANK	DB01996	C6H7N	small molecule	-	108-99-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ITQTTZVARXURQS-UHFFFAOYSA-N
18285	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1920	3-Methylpyridine	-	-	DRUGBANK	DB01996	C6H7N	small molecule	-	108-99-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ITQTTZVARXURQS-UHFFFAOYSA-N
18404	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1971	2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide	-	-	DRUGBANK	DB02049	C19H20ClNO6S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QOPFTBAEAJQKSY-UHFFFAOYSA-N
18423	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1979	SU4984	-	-	DRUGBANK	DB02058	C20H21N3O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AZGZGRJOCKSSHA-GOSISDBHSA-N
18456	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1991	WAY-151693	n-hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-benzamide	-	DRUGBANK	DB02071	C21H21N3O5S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AINJYWXKBKRQSX-UHFFFAOYSA-N
18457	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1991	WAY-151693	n-hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-benzamide	-	DRUGBANK	DB02071	C21H21N3O5S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AINJYWXKBKRQSX-UHFFFAOYSA-N
18458	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1991	WAY-151693	n-hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-benzamide	-	DRUGBANK	DB02071	C21H21N3O5S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AINJYWXKBKRQSX-UHFFFAOYSA-N
18639	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2074	(1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol	-	-	DRUGBANK	DB02158	C12H19N5O2S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YLCQGEBEQIBOOJ-XKBJCNPTSA-N
18640	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2074	(1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol	-	-	DRUGBANK	DB02158	C12H19N5O2S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YLCQGEBEQIBOOJ-XKBJCNPTSA-N
18870	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2190	Formycin	-	-	DRUGBANK	DB02281	C10H12N5O4	small molecule	-	6742-12-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OLDFCABASJKCEZ-IGPDFVGCSA-N
18871	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2190	Formycin	-	-	DRUGBANK	DB02281	C10H12N5O4	small molecule	-	6742-12-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OLDFCABASJKCEZ-IGPDFVGCSA-N
18874	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2191	5'-Deoxy-5'-Methylthioadenosine	-	-	DRUGBANK	DB02282	C11H15N5O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WUUGFSXJNOTRMR-WOIOKPISSA-N
18875	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2191	5'-Deoxy-5'-Methylthioadenosine	-	-	DRUGBANK	DB02282	C11H15N5O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WUUGFSXJNOTRMR-WOIOKPISSA-N
18886	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2203	1-Hydroxy-3-Methylbutane	-	-	DRUGBANK	DB02296	C5H12O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PHTQWCKDNZKARW-UHFFFAOYSA-N
18887	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2203	1-Hydroxy-3-Methylbutane	-	-	DRUGBANK	DB02296	C5H12O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PHTQWCKDNZKARW-UHFFFAOYSA-N
18888	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2203	1-Hydroxy-3-Methylbutane	-	-	DRUGBANK	DB02296	C5H12O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PHTQWCKDNZKARW-UHFFFAOYSA-N
19725	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2586	Hydroxyaminovaline	-	-	DRUGBANK	DB02697	C5H12N2O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	USSBBYRBOWZYSB-SCSAIBSYSA-N
19726	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2586	Hydroxyaminovaline	-	-	DRUGBANK	DB02697	C5H12N2O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	USSBBYRBOWZYSB-SCSAIBSYSA-N
19812	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	unknown	target	Chen X (2002)	11752352	171740	2621	Purvalanol	-	-	DRUGBANK	DB02733	C20H25ClN6O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKDXRFMOHZVXSG-HNNXBMFYSA-N
19943	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2685	3-Phenyl-1,2-Propandiol	-	-	DRUGBANK	DB02803	C9H12O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JHWQMXKQJVAWKI-VIFPVBQESA-N
19944	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2685	3-Phenyl-1,2-Propandiol	-	-	DRUGBANK	DB02803	C9H12O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JHWQMXKQJVAWKI-VIFPVBQESA-N
19945	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2685	3-Phenyl-1,2-Propandiol	-	-	DRUGBANK	DB02803	C9H12O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JHWQMXKQJVAWKI-VIFPVBQESA-N
20059	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2754	Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone	-	-	DRUGBANK	DB02872	C31H34Br2N4O4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PVRYEWOXWGDQHA-FQLXRVMXSA-N
20060	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2754	Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone	-	-	DRUGBANK	DB02872	C31H34Br2N4O4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PVRYEWOXWGDQHA-FQLXRVMXSA-N
20157	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2811	5'-Deoxy-5'-(Methylthio)-Tubercidin	-	-	DRUGBANK	DB02933	C12H16N4O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WBPLMFVTQMIPLW-MFYTUXHUSA-N
20158	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2811	5'-Deoxy-5'-(Methylthio)-Tubercidin	-	-	DRUGBANK	DB02933	C12H16N4O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WBPLMFVTQMIPLW-MFYTUXHUSA-N
20159	110611	4507	-	MTAP	BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2811	5'-Deoxy-5'-(Methylthio)-Tubercidin	-	-	DRUGBANK	DB02933	C12H16N4O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WBPLMFVTQMIPLW-MFYTUXHUSA-N
20336	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2898	2-Methyl-3-(2-Aminothiazolo)Propanal	-	-	DRUGBANK	DB03024	C7H10N2OS	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KFMAJVLZSDMFBV-YFKPBYRVSA-N
20359	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2906	1-Methyloxy-4-Sulfone-Benzene	-	-	DRUGBANK	DB03033	C7H8O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XUNSZADDFLWFOL-UHFFFAOYSA-N
20360	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2906	1-Methyloxy-4-Sulfone-Benzene	-	-	DRUGBANK	DB03033	C7H8O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XUNSZADDFLWFOL-UHFFFAOYSA-N
20367	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2912	Nitrilotriacetic Acid	-	-	DRUGBANK	DB03040	C6H9NO6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MGFYIUFZLHCRTH-UHFFFAOYSA-N
20368	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2912	Nitrilotriacetic Acid	-	-	DRUGBANK	DB03040	C6H9NO6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MGFYIUFZLHCRTH-UHFFFAOYSA-N
20369	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2912	Nitrilotriacetic Acid	-	-	DRUGBANK	DB03040	C6H9NO6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MGFYIUFZLHCRTH-UHFFFAOYSA-N
20912	111695	5723	-	PSPH	PSP|PSPHD	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3157	D-2-Amino-3-Phosphono-Propionic Acid	-	-	DRUGBANK	DB03292	C3H8NO5P	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LBTABPSJONFLPO-REOHCLBHSA-N
20913	111695	5723	-	PSPH	PSP|PSPHD	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3157	D-2-Amino-3-Phosphono-Propionic Acid	-	-	DRUGBANK	DB03292	C3H8NO5P	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LBTABPSJONFLPO-REOHCLBHSA-N
20914	111695	5723	-	PSPH	PSP|PSPHD	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3157	D-2-Amino-3-Phosphono-Propionic Acid	-	-	DRUGBANK	DB03292	C3H8NO5P	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LBTABPSJONFLPO-REOHCLBHSA-N
21098	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	3253	Enalkiren	-	-	DRUGBANK	DB03395	C35H56N6O6	small molecule	-	113082-98-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KQXVERRYBYGQJZ-WRPDIKACSA-N
21301	109643	3417	-	IDH1	HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3316	2'-Monophosphoadenosine 5'-Diphosphoribose	-	-	DRUGBANK	DB03461	C21H28N7O17P3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XJLXINKUBYWONI-XCSFTKGKSA-N
21302	109643	3417	-	IDH1	HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3316	2'-Monophosphoadenosine 5'-Diphosphoribose	-	-	DRUGBANK	DB03461	C21H28N7O17P3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XJLXINKUBYWONI-XCSFTKGKSA-N
21372	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3340	Alpha-D-Fucose	-	-	DRUGBANK	DB03485	C6H12O5	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SHZGCJCMOBCMKK-PHYPRBDBSA-N
21373	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3340	Alpha-D-Fucose	-	-	DRUGBANK	DB03485	C6H12O5	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SHZGCJCMOBCMKK-PHYPRBDBSA-N
21374	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3340	Alpha-D-Fucose	-	-	DRUGBANK	DB03485	C6H12O5	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SHZGCJCMOBCMKK-PHYPRBDBSA-N
21393	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	unknown	target	Chen X (2002)	11752352	171740	3351	Flavopiridol	Alvocidib freebase|Alvocidib	-	DRUGBANK	DB03496	C21H20ClNO5	small molecule	-	146426-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BIIVYFLTOXDAOV-YVEFUNNKSA-N
21394	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	unknown	target	Chen X (2002)	11752352	171740	3351	Flavopiridol	Alvocidib freebase|Alvocidib	-	DRUGBANK	DB03496	C21H20ClNO5	small molecule	-	146426-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BIIVYFLTOXDAOV-YVEFUNNKSA-N
21398	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	unknown	target	Chen X (2002)	11752352	171740	3351	Flavopiridol	Alvocidib freebase|Alvocidib	-	DRUGBANK	DB03496	C21H20ClNO5	small molecule	-	146426-40-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BIIVYFLTOXDAOV-YVEFUNNKSA-N
21576	111082	5045	-	FURIN	FUR|PACE|PCSK3|SPC1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3448	Decanoic Acid	Capric acid	-	DRUGBANK	DB03600	C10H20O2	small molecule	-	334-48-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GHVNFZFCNZKVNT-UHFFFAOYSA-N
21823	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3579	2-Cyclopropylmethylenepropanal	-	-	DRUGBANK	DB03736	C7H12O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NOQCSSAEKDLHCI-ZCFIWIBFSA-N
21824	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3579	2-Cyclopropylmethylenepropanal	-	-	DRUGBANK	DB03736	C7H12O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NOQCSSAEKDLHCI-ZCFIWIBFSA-N
21825	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3579	2-Cyclopropylmethylenepropanal	-	-	DRUGBANK	DB03736	C7H12O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NOQCSSAEKDLHCI-ZCFIWIBFSA-N
22300	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3802	1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine	-	-	DRUGBANK	DB03968	C7H13NO	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YARDEGUIPATLSG-UHFFFAOYSA-N
22301	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3802	1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine	-	-	DRUGBANK	DB03968	C7H13NO	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YARDEGUIPATLSG-UHFFFAOYSA-N
22302	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3802	1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine	-	-	DRUGBANK	DB03968	C7H13NO	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YARDEGUIPATLSG-UHFFFAOYSA-N
22685	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3975	Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone	-	-	DRUGBANK	DB04144	C30H32Cl2N4O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZXIPEZDMQNYFOO-VSGBNLITSA-N
22686	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3975	Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone	-	-	DRUGBANK	DB04144	C30H32Cl2N4O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZXIPEZDMQNYFOO-VSGBNLITSA-N
22687	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3975	Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone	-	-	DRUGBANK	DB04144	C30H32Cl2N4O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZXIPEZDMQNYFOO-VSGBNLITSA-N
23215	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	4189	Debromohymenialdisine	-	-	DRUGBANK	DB04367	C11H10N5O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
23216	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	4189	Debromohymenialdisine	-	-	DRUGBANK	DB04367	C11H10N5O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
23235	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4201	N-Methyl-N-(Methylbenzyl)Formamide	-	-	DRUGBANK	DB04379	C10H13NO	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YYPINKULTUCCJA-VIFPVBQESA-N
23244	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	4209	1-Hydroxy-2-Amino-3-Cyclohexylpropane	-	-	DRUGBANK	DB04387	C9H19NO	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QWDRYURVUDZKSG-VIFPVBQESA-N
23245	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	4209	1-Hydroxy-2-Amino-3-Cyclohexylpropane	-	-	DRUGBANK	DB04387	C9H19NO	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QWDRYURVUDZKSG-VIFPVBQESA-N
23246	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4209	1-Hydroxy-2-Amino-3-Cyclohexylpropane	-	-	DRUGBANK	DB04387	C9H19NO	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QWDRYURVUDZKSG-VIFPVBQESA-N
23407	110714	4629	-	MYH11	AAT4|FAA4|SMHC|SMMHC	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	4258	Tetrafluoroaluminate Ion	-	-	DRUGBANK	DB04444	AlF4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UYOMQIYKOOHAMK-UHFFFAOYSA-J
23408	110714	4629	-	MYH11	AAT4|FAA4|SMHC|SMMHC	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	4258	Tetrafluoroaluminate Ion	-	-	DRUGBANK	DB04444	AlF4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UYOMQIYKOOHAMK-UHFFFAOYSA-J
23409	110714	4629	-	MYH11	AAT4|FAA4|SMHC|SMMHC	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4258	Tetrafluoroaluminate Ion	-	-	DRUGBANK	DB04444	AlF4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UYOMQIYKOOHAMK-UHFFFAOYSA-J
23861	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4546	Nimesulide	-	-	DRUGBANK	DB04743	C13H12N2O5S	small molecule	M01AX17|M02AA26	51803-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HYWYRSMBCFDLJT-UHFFFAOYSA-N
23870	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4562	PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE)	-	-	DRUGBANK	DB04759	C22H22N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GTBUZLPQANSGGE-UHFFFAOYSA-N
23871	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4563	PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE)	-	-	DRUGBANK	DB04760	C22H20F2N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PYFRREJCFXFNRR-UHFFFAOYSA-N
23872	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4564	PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE]	-	-	DRUGBANK	DB04761	C18H16N6O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NHPBWKYFMTXWAA-UHFFFAOYSA-N
24009	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Wedge SR (2005)	15899831	181891	4650	AZD2171	-	-	DRUGBANK	DB04849	C25H27FN4O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XXJWYDDUDKYVKI-UHFFFAOYSA-N
24034	109896	3690	-	ITGB3	BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT	9606	Homo sapiens	unknown	target	Akkerhuis KM (2001)	11250974	181770	4663	Lefradafiban	-	-	DRUGBANK	DB04863	C23H25N3O6	small molecule	-	149503-79-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PGCFXITVMNNKON-ROUUACIJSA-N
24047	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	antagonist	target	Guo T (2007)	17699867	182039	4668	Nilotinib	Nilotinibum	tasigna	DRUGBANK	DB04868	C28H22F3N7O	small molecule	L01XE08	641571-10-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HHZIURLSWUIHRB-UHFFFAOYSA-N
24058	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	inhibitor, competitive	target	Meschini S (2003)	14612920	181837	4677	Voacamine	Voacanginine|Methyl-12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate|Vocamine	-	DRUGBANK	DB04877	C43H52N4O5	small molecule	-	3371-85-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VCMIRXRRQJNZJT-XRMSBCOFSA-N
24059	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	inhibitor, competitive	target	Meschini S (2005)	16273216	181917	4677	Voacamine	Voacanginine|Methyl-12-methoxy-13-(17-methoxy-17-oxovobasan-3alpha-yl)ibogamine-18-carboxylate|Vocamine	-	DRUGBANK	DB04877	C43H52N4O5	small molecule	-	3371-85-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VCMIRXRRQJNZJT-XRMSBCOFSA-N
24066	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Yamamoto A (2007)	17584317	182020	4679	Vatalanib	PTK 787|PTK/ZK|1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate	-	DRUGBANK	DB04879	C20H15ClN4	small molecule	-	212141-54-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YCOYDOIWSSHVCK-UHFFFAOYSA-N
24071	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Hubensack M (2008)	17932689	182056	4681	Elacridar	-	-	DRUGBANK	DB04881	C34H33N3O5	small molecule	-	143664-11-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OSFCMRGOZNQUSW-UHFFFAOYSA-N
24112	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	inhibitor	target	Kohno T (2012)	22716121	182205	4696	Milnacipran	Midalcipran|Milnacipranum|(-)-milnacipran|Milnacipran	milnacipran hydrochloride|save	DRUGBANK	DB04896	C15H22N2O	small molecule	N06AX17	92623-85-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GJJFMKBJSRMPLA-HIFRSBDPSA-N
24113	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	inhibitor	target	Shuto S (1995)	7636857	181687	4696	Milnacipran	Midalcipran|Milnacipranum|(-)-milnacipran|Milnacipran	milnacipran hydrochloride|save	DRUGBANK	DB04896	C15H22N2O	small molecule	N06AX17	92623-85-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GJJFMKBJSRMPLA-HIFRSBDPSA-N
24133	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	inducer	target	Vincent M (2006)	16413681	181926	4705	Tesmilifene	N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine|DPPE|Depmpe	-	DRUGBANK	DB04905	C19H25NO	small molecule	-	98774-23-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NFIXBCVWIPOYCD-UHFFFAOYSA-N
24134	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	inducer	target	Brandes LJ (2001)	10755318	181748	4705	Tesmilifene	N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine|DPPE|Depmpe	-	DRUGBANK	DB04905	C19H25NO	small molecule	-	98774-23-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NFIXBCVWIPOYCD-UHFFFAOYSA-N
24158	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Ahmed NK (1990)	1696922	181642	4717	Alfimeprase	-	-	DRUGBANK	DB04919	-	biologic	-	259074-76-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24160	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	unknown	target	Nordlander M (2004)	15492770	181868	4718	Clevidipine	Clevidipine butyrate	cleviprex	DRUGBANK	DB04920	C21H23Cl2NO6	small molecule	C08CA16	167221-71-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KPBZROQVTHLCDU-UHFFFAOYSA-N
24213	111082	5045	-	FURIN	FUR|PACE|PCSK3|SPC1	9606	Homo sapiens	unknown	target	Burghardt I (2007)	17234158	181983	4745	Pirfenidone	-	esbriet	DRUGBANK	DB04951	C12H11NO	small molecule	L04AX05	53179-13-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ISWRGOKTTBVCFA-UHFFFAOYSA-N
24279	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	unknown	target	Farhan H (2006)	16963623	181966	4779	IGN311	-	-	DRUGBANK	DB04988	-	biologic	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24280	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	unknown	target	Farhan H (2006)	16963623	181966	4779	IGN311	-	-	DRUGBANK	DB04988	-	biologic	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24288	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	unknown	target	Mahadevan D (2007)	17325667	181990	4997	MP470	-	-	DRUGBANK	DB05216	-	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24326	108150	1816	-	DRD5	DBDR|DRD1B|DRD1L2	9606	Homo sapiens	agonist	target	Kvernmo T (2008)	18691132	174662	5046	Rotigotine	(6S)-6-(propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol	neupro	DRUGBANK	DB05271	C19H25NOS	small molecule	N04BC09	99755-59-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KFQYTPMOWPVWEJ-INIZCTEOSA-N
24343	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Spuentrup E (2007)	17948194	182058	5287	EP-2104R	EP 2104R	-	DRUGBANK	DB05675	-	biologic	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24344	108534	2243	-	FGA	Fib2	9606	Homo sapiens	unknown	target	Spuentrup E (2007)	17620942	182028	5287	EP-2104R	EP 2104R	-	DRUGBANK	DB05675	-	biologic	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24352	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antibody	target	Lewis Phillips GD (2008)	19010901	182091	5339	Trastuzumab emtansine	T-DM1|Ado-trastuzumab emtansine|Trastuzumab-DM1|Ado-trastuzumab|Trastuzumab emtansine|Trastuzumab-MCC-DM1	kadcyla	DRUGBANK	DB05773	-	biologic	L01XC14	1018448-65-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24353	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antibody	target	Chen X (2002)	11752352	171740	5339	Trastuzumab emtansine	T-DM1|Ado-trastuzumab emtansine|Trastuzumab-DM1|Ado-trastuzumab|Trastuzumab emtansine|Trastuzumab-MCC-DM1	kadcyla	DRUGBANK	DB05773	-	biologic	L01XC14	1018448-65-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24354	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antibody	target	Barginear MF (2012)	23196784	182221	5339	Trastuzumab emtansine	T-DM1|Ado-trastuzumab emtansine|Trastuzumab-DM1|Ado-trastuzumab|Trastuzumab emtansine|Trastuzumab-MCC-DM1	kadcyla	DRUGBANK	DB05773	-	biologic	L01XC14	1018448-65-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24400	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	activator	target	Lipton SA (2002)	12183209	181801	5519	Acetylcysteine	(R)-Mercapturic acid|N-acetylcysteine|N-Acetyl-L-(+)-cysteine|(2R)-2-acetylamino-3-Sulfanylpropanoic acid|Acetilcisteina|Mercapturic acid|Acetylcysteine|Acetylcysteinum|L-Acetylcysteine|(R)-2-acetylamino-3-Mercaptopropanoic acid|N-ACETYL-L-cysteine|L-alpha-acetamido-beta-Mercaptopropionic acid	parvolex|parvolex liq iv 200mg	DRUGBANK	DB06151	C5H9NO3S	small molecule	V03AB23|S01XA08|R05CB01	616-91-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PWKSKIMOESPYIA-BYPYZUCNSA-N
24412	112239	6335	-	SCN9A	ETHA|FEB3B|GEFSP7|HSAN2D|NE-NA|NENA|Nav1.7|PN1|SFNP	9606	Homo sapiens	modulator	target	Suter MR (2013)	23221868	182223	5525	Rufinamide	RUF 331|Xilep|Banzel	banzel	DRUGBANK	DB06201	C10H8F2N4O	small molecule	N03AF03	106308-44-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	POGQSBRIGCQNEG-UHFFFAOYSA-N
24472	112240	6336	-	SCN10A	FEPS2|Nav1.8|PN3|SNS|hPN3	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5534	Lacosamide	Erlosamide|SPM 927|Harkoseride|Vimpat	lacosamide|vimpat	DRUGBANK	DB06218	C13H18N2O3	small molecule	N03AX18	175481-36-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VPPJLAIAVCUEMN-GFCCVEGCSA-N
24562	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	antibody	target	Franklin MC (2004)	15093539	181845	5550	Pertuzumab	2C4 Antibody|MOAB 2C4|rhuMAb-2C4|Monoclonal Antibody 2C4|Omnitarg	perjeta|perjeta-herceptin	DRUGBANK	DB06366	-	biologic	L01XC13	380610-27-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24574	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Sonpavde G (2007)	17288876	181986	5557	Pazopanib	GW 78603|GW786034|Pazopanibum	votrient	DRUGBANK	DB06589	C21H23N7O2S	small molecule	L01XE11	444731-52-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CUIHSIWYWATEQL-UHFFFAOYSA-N
24577	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Sonpavde G (2007)	17288876	181986	5557	Pazopanib	GW 78603|GW786034|Pazopanibum	votrient	DRUGBANK	DB06589	C21H23N7O2S	small molecule	L01XE11	444731-52-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CUIHSIWYWATEQL-UHFFFAOYSA-N
24580	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	inhibitor	target	Sonpavde G (2007)	17288876	181986	5557	Pazopanib	GW 78603|GW786034|Pazopanibum	votrient	DRUGBANK	DB06589	C21H23N7O2S	small molecule	L01XE11	444731-52-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CUIHSIWYWATEQL-UHFFFAOYSA-N
24593	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Cohen EE (2008)	18541897	182081	5564	Axitinib	-	inlyta	DRUGBANK	DB06626	-	small molecule	L01XE17	319460-85-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24609	114724	9312	-	KCNB2	KV2.2	9606	Homo sapiens	antagonist	target	Judge SI (2006)	16472864	181930	5565	Dalfampridine	Ampyra|4-Pyridylamine|Fampridinum|4-Pyridinamine|N07XX07|P-Aminopyridine|4-AP|EL-970|gamma-Aminopyridine|Dalfampridine|Avitrol|Fampridine-SR|Fampridine|4-Aminopyridine|Fampridina	fampyra|ampyra	DRUGBANK	DB06637	C5H6N2	small molecule	N07XX07	504-24-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NUKYPUAOHBNCPY-UHFFFAOYSA-N
24751	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	inhibitor	target	Peterson BZ (2006)	16675661	174772	5594	Nilvadipine	Nivadil	-	DRUGBANK	DB06712	C19H19N3O6	small molecule	C08CA10	75530-68-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FAIIFDPAEUKBEP-UHFFFAOYSA-N
24777	108835	2561	-	GABRB2	-	9606	Homo sapiens	potentiator	target	Franks NP (2006)	16402123	174522	5598	Fospropofol	Fospropofol	lusedra	DRUGBANK	DB06716	C13H21O5P	small molecule	-	258516-89-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QVNNONOFASOXQV-UHFFFAOYSA-N
24800	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Ebert B (1995)	7624018	181686	5615	Ketobemidone	Ketorax|Cetobemidona|Ketodur|Cliradon|Ketobemidone|Ketogan|Cetobemidone|Cymidon|Cetobemidonum	-	DRUGBANK	DB06738	C15H21NO2	small molecule	N02AB01|N02AG02	469-79-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ALFGKMXHOUSVAD-UHFFFAOYSA-N
24810	109160	2903	RP11-297M9.2	GRIN2A	EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A	9606	Homo sapiens	antagonist	target	Warach S (2005)	16340185	181922	5616	Gavestinel	-	-	DRUGBANK	DB06741	-	small molecule	-	153436-22-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24925	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5718	N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE	-	-	DRUGBANK	DB06899	C20H26N6O2S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RMEVNJZCKDVVND-UHFFFAOYSA-N
24961	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5757	4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide	-	-	DRUGBANK	DB06938	C21H15ClF3N5O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZJLSMLDOCGOURY-UHFFFAOYSA-N
24986	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5786	6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE	-	-	DRUGBANK	DB06967	C22H25N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLSVRCGEBXIIQO-UHFFFAOYSA-N
25001	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5805	2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE	-	-	DRUGBANK	DB06987	C14H22N2O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	METKIMKYRPQLGS-GFCCVEGCSA-N
25012	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5817	N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide	-	-	DRUGBANK	DB06999	C17H14ClF2N3O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YZDJQTHVDDOVHR-UHFFFAOYSA-N
25013	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5818	N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide	-	-	DRUGBANK	DB07000	C21H16F2N4O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ILXJWLWSYAWJKZ-UHFFFAOYSA-N
25027	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5831	TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE	-	-	DRUGBANK	DB07013	C22H31N3O6S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RXFCFGLSOUOCEA-UHFFFAOYSA-N
25033	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5838	N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide	-	-	DRUGBANK	DB07020	C20H14N6O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LMDMJDCLPIVGQD-UHFFFAOYSA-N
25064	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5877	N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE	-	-	DRUGBANK	DB07059	C20H26N6O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GBXSOZDYCSBLQX-UHFFFAOYSA-N
25122	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5931	(2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE	-	-	DRUGBANK	DB07113	C24H25F2N5O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KHZQOXQOUCGGGA-NRFANRHFSA-N
25182	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5991	6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE	-	-	DRUGBANK	DB07174	C20H27N5O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WPAPODFGOZXFLG-UHFFFAOYSA-N
25190	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6000	N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide	-	-	DRUGBANK	DB07183	C24H20N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CPVRYQAOUPSUDO-UHFFFAOYSA-N
25254	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6060	5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE	-	-	DRUGBANK	DB07244	C19H19F2N5	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SRRWXMSVQYQCRX-UHFFFAOYSA-N
25286	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6090	N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	-	-	DRUGBANK	DB07274	C25H22N2O4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZATGFXTWDKIEKC-UHFFFAOYSA-N
25333	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6142	6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide	-	-	DRUGBANK	DB07326	C19H11ClF3N5O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FEGRQUWSKADGSP-UHFFFAOYSA-N
25337	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6149	N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE	-	-	DRUGBANK	DB07333	C25H24N4O4S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KRGKAARWVPUWSY-UHFFFAOYSA-N
25338	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6150	N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE	-	-	DRUGBANK	DB07334	C23H21N3O4S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HTIZPBXCJPQDEM-UHFFFAOYSA-N
25397	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6195	(2S)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol	(2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol|Aminopurvalanol	-	DRUGBANK	DB07379	C19H26ClN7O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RAMROQQYRRQPDL-OAHLLOKOSA-N
25533	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6325	3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one	-	-	DRUGBANK	DB07514	C24H23N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LHLGUOHREUTYTO-UHFFFAOYSA-N
25540	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6335	3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine	-	-	DRUGBANK	DB07525	C15H14N2O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GHQCCHWTDLTMJT-UHFFFAOYSA-N
25542	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6338	3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one	-	-	DRUGBANK	DB07528	C21H15F3N4O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HXUZQEYFKAZBPX-UHFFFAOYSA-N
25552	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6347	N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide	-	-	DRUGBANK	DB07537	C21H26N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CLEGTVIMOPPIBR-UHFFFAOYSA-N
25610	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6408	S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE	-	-	DRUGBANK	DB07602	C20H21N5O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NLVZTRZPMRTVRC-INIZCTEOSA-N
25666	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6468	N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE	-	-	DRUGBANK	DB07662	C17H13BrN4O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HTUBKQUPEREOGA-UHFFFAOYSA-N
25823	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6594	3,7,3',4'-TETRAHYDROXYFLAVONE	-	-	DRUGBANK	DB07795	C15H10O6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XHEFDIBZLJXQHF-UHFFFAOYSA-N
25846	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6625	4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID	-	-	DRUGBANK	DB07827	C26H20N2O4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FLTYDFYSVZBKOB-UHFFFAOYSA-N
25858	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6637	(E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol	-	-	DRUGBANK	DB07840	C21H14F2N2O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HQMUBYFTZASKLP-ZZEZOPTASA-N
26062	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6835	N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine	-	-	DRUGBANK	DB08042	C22H24N6O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	FLXGQDHYCWXTAI-UHFFFAOYSA-N
26080	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6852	(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE	-	-	DRUGBANK	DB08059	C23H24O8	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QDLHCMPXEPAAMD-QAIWCSMKSA-N
26081	111308	5290	-	PIK3CA	CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6852	(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE	-	-	DRUGBANK	DB08059	C23H24O8	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QDLHCMPXEPAAMD-QAIWCSMKSA-N
26127	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6892	6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine	-	-	DRUGBANK	DB08099	C25H31N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UOYVKYJWAXJTTE-NRFANRHFSA-N
26240	112869	7010	-	TEK	CD202B|TIE-2|TIE2|VMCM|VMCM1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7012	N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE	-	-	DRUGBANK	DB08221	C24H18F3N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NESXBRNDMQUVNG-UHFFFAOYSA-N
26413	113010	7157	-	TP53	BCC7|LFS1|P53|TRP53	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7148	1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine	-	-	DRUGBANK	DB08363	C16H18N2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LBPNOEAFWYTTEB-UHFFFAOYSA-N
26434	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7172	5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE	-	-	DRUGBANK	DB08388	C20H19FN2O6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XRSYNYGEEYTXJV-UHFFFAOYSA-N
26491	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7221	Parecoxib	-	-	DRUGBANK	DB08439	C19H18N2O4S	small molecule	M01AH04	198470-84-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	TZRHLKRLEZJVIJ-UHFFFAOYSA-N
26536	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7270	CTS-1027	4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE|193022-04-7|RS-130830|Ro-1130830	-	DRUGBANK	DB08490	C19H20ClNO6S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ROSNVSQTEGHUKU-UHFFFAOYSA-N
26568	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7297	N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine	-	-	DRUGBANK	DB08519	C21H22N6O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SQQAPOSROFWHIB-UHFFFAOYSA-N
26596	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7331	(1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime	-	-	DRUGBANK	DB08553	C22H23N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KWEFZSZCLBHIEQ-YYADALCUSA-N
26602	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7339	BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE	-	-	DRUGBANK	DB08561	C21H16N2O4S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PLBINCOCFGQAJM-UHFFFAOYSA-N
26618	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7354	3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE	-	-	DRUGBANK	DB08577	C17H16N2O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JNDVEAXZWJIOKB-JYRVWZFOSA-N
26937	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	antagonist	target	Yakes FM (2011)	21926191	182194	7619	Cabozantinib	-	cometriq|cabometyx	DRUGBANK	DB08875	C28H24FN3O5	small molecule	L01XE26	849217-68-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ONIQOQHATWINJY-UHFFFAOYSA-N
26938	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	antagonist	target	Kurzrock R (2011)	21606412	182188	7619	Cabozantinib	-	cometriq|cabometyx	DRUGBANK	DB08875	C28H24FN3O5	small molecule	L01XE26	849217-68-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ONIQOQHATWINJY-UHFFFAOYSA-N
26948	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Jordan EJ (2012)	23094782	182216	7625	Vemurafenib	Zelboraf|PLX4032|BRAF(V600E) Kinase Inhibitor RO5185426	zelboraf	DRUGBANK	DB08881	C23H18ClF2N3O3S	small molecule	L01XE15	918504-65-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GPXBXXGIAQBQNI-UHFFFAOYSA-N
26954	108621	2335	-	FN1	CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF	9606	Homo sapiens	cleavage	target	Tsui I (2012)	23193358	182220	7632	Ocriplasmin	-	jetrea	DRUGBANK	DB08888	C1214H1890N338O348S14	biologic	S01XA22	1048016-09-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
26968	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	inhibitor	target	Ren M (2013)	23563700	182243	7645	Ponatinib	AP24534|AP 24534|Ponatinibum	iclusig	DRUGBANK	DB08901	C29H27F3N6O	small molecule	L01XE24	943319-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PHXJVRSECIGDHY-UHFFFAOYSA-N
26969	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	inhibitor	target	Gozgit JM (2013)	23468082	182234	7645	Ponatinib	AP24534|AP 24534|Ponatinibum	iclusig	DRUGBANK	DB08901	C29H27F3N6O	small molecule	L01XE24	943319-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PHXJVRSECIGDHY-UHFFFAOYSA-N
26970	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	O'Hare T (2009)	19878872	182132	7645	Ponatinib	AP24534|AP 24534|Ponatinibum	iclusig	DRUGBANK	DB08901	C29H27F3N6O	small molecule	L01XE24	943319-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PHXJVRSECIGDHY-UHFFFAOYSA-N
26972	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Gleixner KV (2013)	23539538	182238	7645	Ponatinib	AP24534|AP 24534|Ponatinibum	iclusig	DRUGBANK	DB08901	C29H27F3N6O	small molecule	L01XE24	943319-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PHXJVRSECIGDHY-UHFFFAOYSA-N
26975	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	inhibitor	target	O'Hare T (2009)	19878872	182132	7645	Ponatinib	AP24534|AP 24534|Ponatinibum	iclusig	DRUGBANK	DB08901	C29H27F3N6O	small molecule	L01XE24	943319-70-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PHXJVRSECIGDHY-UHFFFAOYSA-N
26991	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Gibney GT (2013)	23621583	182249	7656	Dabrafenib	Dabrafenib|GSK2118436a	tafinlar	DRUGBANK	DB08912	C23H20F3N5O2S2	small molecule	L01XE23	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BFSMGDJOXZAERB-UHFFFAOYSA-N
27069	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Ekins S (2002)	11961113	172332	192	Erythromycin	Erythromycine|(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione|Erythromycin C|3''-O-demethylerythromycin|Erythromycin A|Eritromicina|Erythromycin|rythromycine|Abomacetin|Erythromycinum	erythro-base tab 250mg usp|ery	DRUGBANK	DB00199	C37H67NO13	small molecule	J01FA01|S01AA17|D10AF52|D10AF02	114-07-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ULGZDMOVFRHVEP-RWJQBGPGSA-N
27080	112869	7010	-	TEK	CD202B|TIE-2|TIE2|VMCM|VMCM1	9606	Homo sapiens	unknown	target	Gong XW (2012)	22406116	188480	407	Ampicillin	D-(-)-Ampicillin|D-()-6-(-aminophenylacetamido)penicillanic acid|D-()-ampicillin|Aminobenzylpenicillin|Ampicilina|(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylethanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid|Ampicillin Acid|D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid|Ampicilline|Ampicillinum|(2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid|Anhydrous ampicillin|AP|Ampicillin Anhydrous|AMP|Ampicillin|6-(D-(2-amino-2-Phenylacetamido))-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid|ABPC	penbritin pws 250mg/5ml|ampici	DRUGBANK	DB00415	C16H19N3O4S	small molecule	S01AA19|J01CR01|J01CA51|J01CA01	69-53-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AVKUERGKIZMTKX-NJBDSQKTSA-N
27140	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Wang EJ (2001)	11716514	172321	835	Clofazimine	Clofazimine|Clofazimina|Clofaziminum|Clofazimin|Riminophenazine|Lamprene	-	DRUGBANK	DB00845	C27H22Cl2N4	small molecule	J04BA01	2030-63-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WDQPAMHFFCXSNU-BGABXYSRSA-N
27154	107233	779	-	CACNA1S	CACNL1A3|CCHL1A3|Cav1.1|HOKPP|HOKPP1|MHS5|TTPP1|hypoPP	9606	Homo sapiens	unknown	target	Hendricson AW (2003)	12970385	188490	888	Ethanol	thanol|Methylcarbinol|Ethyl Alcohol|Alcohol|Alcohol etlico|thylalkohol|Grain alcohol|Alcohol (ethyl)|1-Hydroxyethane|Alcohol anhydrous|thanol|Alcohol, denatured|etanol|Dehydrated ethanol|Spiritus vini|Hydroxyethane|Alkohol|Alcool thylique|Alcohol denatured	lisa frank bubblegum antisepti	DRUGBANK	DB00898	C2H6O	small molecule	D08AX08|V03AB16|V03AZ01	64-17-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LFQSCWFLJHTTHZ-UHFFFAOYSA-N
27157	108833	2559	-	GABRA6	-	9606	Homo sapiens	unknown	target	Santhakumar V (2007)	17591544	178935	888	Ethanol	thanol|Methylcarbinol|Ethyl Alcohol|Alcohol|Alcohol etlico|thylalkohol|Grain alcohol|Alcohol (ethyl)|1-Hydroxyethane|Alcohol anhydrous|thanol|Alcohol, denatured|etanol|Dehydrated ethanol|Spiritus vini|Hydroxyethane|Alkohol|Alcool thylique|Alcohol denatured	lisa frank bubblegum antisepti	DRUGBANK	DB00898	C2H6O	small molecule	D08AX08|V03AB16|V03AZ01	64-17-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LFQSCWFLJHTTHZ-UHFFFAOYSA-N
27170	108835	2561	-	GABRB2	-	9606	Homo sapiens	unknown	target	Santhakumar V (2007)	17591544	178935	888	Ethanol	thanol|Methylcarbinol|Ethyl Alcohol|Alcohol|Alcohol etlico|thylalkohol|Grain alcohol|Alcohol (ethyl)|1-Hydroxyethane|Alcohol anhydrous|thanol|Alcohol, denatured|etanol|Dehydrated ethanol|Spiritus vini|Hydroxyethane|Alkohol|Alcool thylique|Alcohol denatured	lisa frank bubblegum antisepti	DRUGBANK	DB00898	C2H6O	small molecule	D08AX08|V03AB16|V03AZ01	64-17-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LFQSCWFLJHTTHZ-UHFFFAOYSA-N
27243	111262	5243	-	ABCB1	ABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1	9606	Homo sapiens	unknown	target	Wang EJ (2001)	11716514	172321	1199	Clarithromycin	Clarithromycine|Clarithromycina|6-O-Methylerythromycin a|6-O-Methylerythromycin|CLA|CLARITHROMYCIN|6-O-methyl erythromycin|Clarithromycinum	clarithromycin 500 mg|mylan-cl	DRUGBANK	DB01211	C38H69NO13	small molecule	J01FA09|A02BD11|A02BD07|A02BD04|A02BD05|A02BD06|A02BD09	81103-11-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AGOYDEPGAOXOCK-KCBOHYOISA-N
27367	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	antagonist	target	Goodkin R (1990)	2182794	188513	7762	Ramucirumab	-	cyramza	DRUGBANK	DB05578	C6374H9864N1692O1996S46	biologic	L01XC21	947687-13-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
27445	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Wood JM (2003)	12927775	188528	7758	Aliskiren	-	rasilez hct|tekturna hct|amtur	DRUGBANK	DB09026	C30H53N3O6	small molecule	C09XA53|C09XA52|C09DX02|C09XA02|C09XA54	173334-57-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXOWGYHJODZGMF-QORCZRPOSA-N
27446	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Gradman AH (2006)	16965731	188529	7758	Aliskiren	-	rasilez hct|tekturna hct|amtur	DRUGBANK	DB09026	C30H53N3O6	small molecule	C09XA53|C09XA52|C09DX02|C09XA02|C09XA54	173334-57-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXOWGYHJODZGMF-QORCZRPOSA-N
27447	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Nussberger J (2002)	11799102	188526	7758	Aliskiren	-	rasilez hct|tekturna hct|amtur	DRUGBANK	DB09026	C30H53N3O6	small molecule	C09XA53|C09XA52|C09DX02|C09XA02|C09XA54	173334-57-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXOWGYHJODZGMF-QORCZRPOSA-N
27448	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Menard J (2006)	16467656	188527	7758	Aliskiren	-	rasilez hct|tekturna hct|amtur	DRUGBANK	DB09026	C30H53N3O6	small molecule	C09XA53|C09XA52|C09DX02|C09XA02|C09XA54	173334-57-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXOWGYHJODZGMF-QORCZRPOSA-N
27449	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	7758	Aliskiren	-	rasilez hct|tekturna hct|amtur	DRUGBANK	DB09026	C30H53N3O6	small molecule	C09XA53|C09XA52|C09DX02|C09XA02|C09XA54	173334-57-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXOWGYHJODZGMF-QORCZRPOSA-N
27450	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Azizi M (2006)	16508564	188525	7758	Aliskiren	-	rasilez hct|tekturna hct|amtur	DRUGBANK	DB09026	C30H53N3O6	small molecule	C09XA53|C09XA52|C09DX02|C09XA02|C09XA54	173334-57-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UXOWGYHJODZGMF-QORCZRPOSA-N
27477	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	inhibitor	target	Fry DW (2004)	15542782	188549	7820	Palbociclib	6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one	ibrance	DRUGBANK	DB09073	C24H29N7O2	small molecule	L01XE33	571190-30-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AHJRHEGDXFFMBM-UHFFFAOYSA-N
27478	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	inhibitor	target	Fry DW (2004)	15542782	188549	7820	Palbociclib	6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one	ibrance	DRUGBANK	DB09073	C24H29N7O2	small molecule	L01XE33	571190-30-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AHJRHEGDXFFMBM-UHFFFAOYSA-N
27491	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	inhibitor	target	Matsui J (2008)	17943726	188553	7825	Lenvatinib	4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide|Lenvatinib Mesylate	lenvima	DRUGBANK	DB09078	C21H19ClN4O4	small molecule	L01XE29	417716-92-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WOSKHXYHFSIKNG-UHFFFAOYSA-N
27492	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Matsui J (2008)	17943726	188553	7825	Lenvatinib	4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide|Lenvatinib Mesylate	lenvima	DRUGBANK	DB09078	C21H19ClN4O4	small molecule	L01XE29	417716-92-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WOSKHXYHFSIKNG-UHFFFAOYSA-N
27494	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Matsui J (2008)	17943726	188553	7825	Lenvatinib	4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide|Lenvatinib Mesylate	lenvima	DRUGBANK	DB09078	C21H19ClN4O4	small molecule	L01XE29	417716-92-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WOSKHXYHFSIKNG-UHFFFAOYSA-N
27499	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	inhibitor	target	Hilberg F (2008)	18559524	188554	7826	Nintedanib	methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate	ofev	DRUGBANK	DB09079	C31H33N5O4	small molecule	L01XE31	656247-17-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZXHXSATPCNXJR-ZIADKAODSA-N
27500	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Hilberg F (2008)	18559524	188554	7826	Nintedanib	methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate	ofev	DRUGBANK	DB09079	C31H33N5O4	small molecule	L01XE31	656247-17-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZXHXSATPCNXJR-ZIADKAODSA-N
27593	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Schueneman AJ (2003)	12873999	180937	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27594	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27595	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Baratte S (2004)	14753710	180935	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27596	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Amino N (2006)	16533791	180934	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27597	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Schoeffski P (2006)	16418310	175821	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27598	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	inhibitor	target	Mendel DB (2003)	12538485	180936	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27601	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Joensuu H (2007)	17545799	180940	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27602	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27603	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Roskoski R (2007)	17367763	180930	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27604	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Baratte S (2004)	14753710	180935	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27605	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Schueneman AJ (2003)	12873999	180937	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27606	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor	target	Abrams TJ (2003)	12748309	180939	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27614	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	inhibitor	target	Prenen H (2006)	16638875	180943	1255	Sunitinib	Sunitinibum	sutent	DRUGBANK	DB01268	C22H27FN4O2	small molecule	L01XE04	557795-19-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WINHZLLDWRZWRT-ATVHPVEESA-N
27669	110235	4057	-	LTF	GIG12|HEL110|HLF2|LF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	8062	Lauric Acid	Dodecanoic acid|N-dodecanoic acid|DAO|Coconut oil fatty acids|Undecane-1-carboxylic acid|Duodecylic acid|Dodecylic acid|C12:0|Dodecanoate|C12 fatty acid|ABL|Dodecylcarboxylate|Laurinsaeure|1-Undecanecarboxylic acid|N-dodecanoate|Laurostearic acid|Dodecoic acid|Vulvic acid|Duodecyclic acid	vitafol plus	DRUGBANK	DB03017	C12H24O2	small molecule	-	143-07-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	POULHZVOKOAJMA-UHFFFAOYSA-N
27781	108833	2559	-	GABRA6	-	9606	Homo sapiens	unknown	target	Davies M (2003)	12921221	195958	888	Ethanol	thanol|Methylcarbinol|Ethyl Alcohol|Alcohol|Alcohol etlico|thylalkohol|Grain alcohol|Alcohol (ethyl)|1-Hydroxyethane|Alcohol anhydrous|thanol|Alcohol, denatured|etanol|Dehydrated ethanol|Spiritus vini|Hydroxyethane|Alkohol|Alcool thylique|Alcohol denatured	lisa frank bubblegum antisepti	DRUGBANK	DB00898	C2H6O	small molecule	D08AX08|V03AB16|V03AZ01	64-17-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LFQSCWFLJHTTHZ-UHFFFAOYSA-N
27785	108835	2561	-	GABRB2	-	9606	Homo sapiens	unknown	target	Davies M (2003)	12921221	195958	888	Ethanol	thanol|Methylcarbinol|Ethyl Alcohol|Alcohol|Alcohol etlico|thylalkohol|Grain alcohol|Alcohol (ethyl)|1-Hydroxyethane|Alcohol anhydrous|thanol|Alcohol, denatured|etanol|Dehydrated ethanol|Spiritus vini|Hydroxyethane|Alkohol|Alcool thylique|Alcohol denatured	lisa frank bubblegum antisepti	DRUGBANK	DB00898	C2H6O	small molecule	D08AX08|V03AB16|V03AZ01	64-17-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LFQSCWFLJHTTHZ-UHFFFAOYSA-N
27802	111904	5972	-	REN	HNFJ2	9606	Homo sapiens	inhibitor	target	Glassman HN (1990)	1705633	195971	3253	Enalkiren	-	-	DRUGBANK	DB03395	C35H56N6O6	small molecule	-	113082-98-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KQXVERRYBYGQJZ-WRPDIKACSA-N
27908	112174	6262	RP4-626J7.1	RYR2	ARVC2|ARVD2|RYR-2|RyR|VTSIP	9606	Homo sapiens	modulator	target	Lanner JT (2010)	20961976	195999	7831	Tetracaine	Pontocaine|Ttracane|Medihaler-Tetracaine|2-(dimethylamino)ethyl 4-(butylamino)benzoate|p-(butylamino)benzoic acid -(dimethylamino)ethyl ester|p-Butylaminobenzoyl-2-dimethylaminoethanol|Dicaine|Amethocaine|Tetracaine HCl|Metraspray|Dithylaminothanol ester der p-butylaminobenzsure|Tetracana|Pontocaine HCl|Amethocaine HCl|2-(Dimethylamino)ethyl p-(butylamino)benzoate	denti-care denti-freeze topica	DRUGBANK	DB09085	C15H24N2O2	small molecule	D04AB06|N01BA03|C05AD02|S01HA03	94-24-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GKCBAIGFKIBETG-UHFFFAOYSA-N
27909	112174	6262	RP4-626J7.1	RYR2	ARVC2|ARVD2|RYR-2|RyR|VTSIP	9606	Homo sapiens	modulator	target	Laver DR (2011)	21624373	196008	7831	Tetracaine	Pontocaine|Ttracane|Medihaler-Tetracaine|2-(dimethylamino)ethyl 4-(butylamino)benzoate|p-(butylamino)benzoic acid -(dimethylamino)ethyl ester|p-Butylaminobenzoyl-2-dimethylaminoethanol|Dicaine|Amethocaine|Tetracaine HCl|Metraspray|Dithylaminothanol ester der p-butylaminobenzsure|Tetracana|Pontocaine HCl|Amethocaine HCl|2-(Dimethylamino)ethyl p-(butylamino)benzoate	denti-care denti-freeze topica	DRUGBANK	DB09085	C15H24N2O2	small molecule	D04AB06|N01BA03|C05AD02|S01HA03	94-24-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GKCBAIGFKIBETG-UHFFFAOYSA-N
27930	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	inhibitor	target	Yosaatmadja Y (2015)	26522274	196035	8129	Osimertinib	N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide|Mereletinib	tagrisso	DRUGBANK	DB09330	C28H33N7O2	small molecule	-	1421373-65-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DUYJMQONPNNFPI-UHFFFAOYSA-N
27933	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	antagonist	target	Kuenen B (2010)	20197484	195996	8209	Necitumumab	-	portrazza	DRUGBANK	DB09559	-	biologic	L01XC22	906805-06-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
27939	108833	2559	-	GABRA6	-	9606	Homo sapiens	antagonist	target	Carta M (2006)	16806306	195970	8251	Thiocolchicoside	Thiocolchicine 2-glucoside analog|TCC	-	DRUGBANK	DB11582	C27H33NO10S	small molecule	M03BX05|M03BX55	602-41-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEQAKWQJCITZNK-AXHKHJLKSA-N
27940	108833	2559	-	GABRA6	-	9606	Homo sapiens	antagonist	target	Mascia MP (2007)	17234181	195976	8251	Thiocolchicoside	Thiocolchicine 2-glucoside analog|TCC	-	DRUGBANK	DB11582	C27H33NO10S	small molecule	M03BX05|M03BX55	602-41-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEQAKWQJCITZNK-AXHKHJLKSA-N
27951	108835	2561	-	GABRB2	-	9606	Homo sapiens	antagonist	target	Carta M (2006)	16806306	195970	8251	Thiocolchicoside	Thiocolchicine 2-glucoside analog|TCC	-	DRUGBANK	DB11582	C27H33NO10S	small molecule	M03BX05|M03BX55	602-41-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEQAKWQJCITZNK-AXHKHJLKSA-N
27952	108835	2561	-	GABRB2	-	9606	Homo sapiens	antagonist	target	Mascia MP (2007)	17234181	195976	8251	Thiocolchicoside	Thiocolchicine 2-glucoside analog|TCC	-	DRUGBANK	DB11582	C27H33NO10S	small molecule	M03BX05|M03BX55	602-41-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LEQAKWQJCITZNK-AXHKHJLKSA-N
28006	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	unknown	target	Doi T (2014)	24816152	198177	8285	Olaratumab	Lartruvo	lartruvo	DRUGBANK	DB06043	-	biologic	-	1024603-93-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
28007	111182	5156	-	PDGFRA	CD140A|PDGFR-2|PDGFR2|RHEPDGFRA	9606	Homo sapiens	unknown	target	van der Graaf WT (2016)	27291995	198178	8285	Olaratumab	Lartruvo	lartruvo	DRUGBANK	DB06043	-	biologic	-	1024603-93-7	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
28030	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited E3 ligase	Schneekloth AR (2008)	18752944	85706	8420	Bivalent ligand 9	Bivalent_ligand_9|PROTAC 14|Protac-14	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	106862	367	RP11-383C12.1	AR	AIS|DHTR|HUMARA|HYSP1|KD|NR3C4|SBMA|SMAX1|TFM	9606	Homo sapiens	target	Standardized BVL Name: PROTAC 14(MDM2:nutlin-3 --- AR:SARM)	-
28091	116031	10818	-	FRS2	FRS2A|FRS2alpha|SNT|SNT-1|SNT1	9606	Homo sapiens	degradation	target	Hines J (2013)	23674677	194582	8460	Bivalent ligand 30	Bivalent_ligand_30|TrkAPPFRS2a|phosphoPROTAC	-	BIOGRID	-	-	polypeptidic	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: TrkAPPFRS2alpha(VHL:HIF1alpha septapeptide --- FRS2a:phosphorylated TrkA-derived decapeptide sequence)	-
28101	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	degradation	target	Hines J (2013)	23674677	194582	8455	Bivalent ligand 35	Bivalent_ligand_35|ErbB2PPPI3K|phosphoPROTAC	-	BIOGRID	-	-	polypeptidic	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: ErbB2PPPI3K(VHL:HIF1alpha septapeptide --- PI3K:ErbB3 peptide)	-
28139	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Burslem GM (2018)	29129716	211414	8440	Bivalent ligand 52	Bivalent_ligand_52|MS4077|MS4078|COMPOUND 1	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: compound 1(VHL:Ligand 9 --- EGFR:lapatinib)	-
28141	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Burslem GM (2018)	29129716	211414	8439	Bivalent ligand 53	Bivalent_ligand_53|COMPOUND 2	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: compound 3(VHL:Ligand 9 --- EGFR:gefitinib)	-
28143	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Burslem GM (2018)	29129716	211414	8442	Bivalent ligand 54	Bivalent_ligand_54|COMPOUND 3	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: compound 4(VHL:Ligand 9 --- EGFR:afatinib)	-
28145	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	degradation	target	Burslem GM (2018)	29129716	211414	8440	Bivalent ligand 52	Bivalent_ligand_52|MS4077|MS4078|COMPOUND 1	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: compound 1(VHL:Ligand 9--- HER2:lapatinib)	-
28303	106524	2	-	A2M	A2MD|CPAMD5|FWP007|S863-7	9606	Homo sapiens	degradation	target	Bondeson DP (2018)	29129718	208144	8429	Bivalent ligand 64	Bivalent_ligand_64|PROTAC 2	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: PROTAC2(CRBN:CRBN ligand --- A2M:foretinib)	-
28398	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Zhang Z (2014)	24900784	211364	8355	RO5353	Spiro[pyrrolidine-3,6'-[6H]thieno[3,2-b]pyrrole]-5-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-4',5'-dihydro-5'-oxo-, (2S,3R,4R,5R)-|(2S,3R,4R,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide	-	CHEMSPIDER	31135029	C29H29Cl2FN4O4S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	UOVSZRTTWLJPHE-HNXAPSNLSA-N
28399	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Zhang Z (2014)	24900784	211364	8356	RO2468	(2S,3R,4S,5R)-N-(4-Carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-(2,2-dimethylpropyl)-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide	-	CHEMSPIDER	31135031	C30H30Cl2FN5O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	CGCOPBXAGSCZNX-FNQJWKMRSA-N
28400	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Tan G (2017)	28549433	207226	8357	JS-K	Ethyl 4-[(E)-(2,4-dinitrophenoxy)-NNO-azoxy]-1-piperazinecarboxylate|1-Piperazinecarboxylic acid, 4-[(E)-(2,4-dinitrophenoxy)-NNO-azoxy]-, ethyl ester	-	CHEMSPIDER	24684273	C13H16N6O8	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	DNJRNBYZLPKSHV-XMHGGMMESA-N
28430	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Tovar C (2013)	23400593	211352	8379	RG7112	RO-5045337|Q8MI0X869M|{(4S,5R)-4,5-Bis(4-chlorophenyl)-2-[2-ethoxy-4-(2-methyl-2-propanyl)phenyl]-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl}{4-[3-(methylsulfonyl)propyl]-1-piperazinyl}methanone|Methanone, [(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]-	-	CHEMSPIDER	28189760	C38H48Cl2N4O4S	small molecule	-	939981-39-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	QBGKPEROWUKSBK-QPPIDDCLSA-N
28431	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Ding Q (2013)	23808545	211356	8380	RG7388	idasanutlin|4-{[(3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-D-prolyl]amino}-3-methoxybenzoic acid|Benzoic acid, 4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-	-	CHEMSPIDER	30831264	C31H29Cl2F2N3O4	small molecule	-	1229705-06-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	TVTXCJFHQKSQQM-LJQIRTBHSA-N
28432	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Bill KL (2016)	26475335	211379	8381	SAR405838	8570LZ3RCA|SAR-405838|Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2'S,3R,4'S,5'R)-|(2'S,3R,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide	-	CHEMSPIDER	30811498	C29H34Cl2FN3O3	small molecule	-	1303607-60-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	IDKAKZRYYDCJDU-HBMMIIHUSA-N
28433	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Shangary S (2008)	18316739	208243	8382	MI-219	(2'R,3R,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-5-fluoro-2'-(2-methyl-2-propanyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide|Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(1,1-dimethylethyl)-5-fluoro-1,2-dihydro-2-oxo-, (2'R,3R,4'R,5'R)-	-	CHEMSPIDER	59695355	C26H30Cl2FN3O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	KUMSTKUNLHZBEQ-MWFJYFKBSA-N
28505	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Zhou Y (2018)	29670376	212575	8591	Butein	Butein|Chalcone, 2',3,4,4'-tetrahydroxy- (7CI,8CI)|2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)-|(2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one|(2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one|(E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one|2056928|4WVS5M0LGF|(2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one[	-	CHEMSPIDER	4444634	C15H12O5	small molecule	-	487-52-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	AYMYWHCQALZEGT-ORCRQEGFSA-N
28525	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Lu J (2016)	27764791	216708	8381	SAR405838	8570LZ3RCA|SAR-405838|Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2'S,3R,4'S,5'R)-|(2'S,3R,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide	-	CHEMSPIDER	30811498	C29H34Cl2FN3O3	small molecule	-	1303607-60-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	IDKAKZRYYDCJDU-HBMMIIHUSA-N
28529	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Sznarkowska A (2019)	30603043	218393	2193	Protoporphyrin Ix	protoporphyrin IX|protoporphyrin|553-12-8|Ooporphyrin|Protoporpyrin IX|ppIX|Porphyrinogen IX|Protoporphyrin IX disodium|Kammerers prophyrin	-	DRUGBANK	DB02285	C34H33N4O4	small molecule	-	553-12-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	PpIX ablates TAp73/MDM2, TAp73/MDMX and TAp73/Itch complexes	-
28530	110359	4194	RP11-430C7.1	MDM4	HDMX|MDMX|MRP1	9606	Homo sapiens	inhibitor	target	Sznarkowska A (2019)	30603043	218393	2193	Protoporphyrin Ix	protoporphyrin IX|protoporphyrin|553-12-8|Ooporphyrin|Protoporpyrin IX|ppIX|Porphyrinogen IX|Protoporphyrin IX disodium|Kammerers prophyrin	-	DRUGBANK	DB02285	C34H33N4O4	small molecule	-	553-12-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	PpIX ablates TAp73/MDM2, TAp73/MDMX and TAp73/Itch complexes	-
28540	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Lain S (2008)	18455128	78113	8621	Tenovin-1	N-[4-({[(4-tert-butylbenzoyl)amino]carbothioyl}amino)phenyl]acetamide|Tenovin-1|N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide|Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-|N-[(4-Acetamidophenyl)carbamothioyl]-4-(2-methyl-2-propanyl)benzamide|N-[(4-acetamidoanilino)-sulfanylidenemethyl]-4-tert-butylbenzamide|BIQ6AID2B7	-	CHEMSPIDER	875023	C20H23N3O2S	small molecule	-	380315-80-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Tenovin-1 protects against MDM2-mediated p53 degradation and inhibits the protein deacetylating activities of SirT1 and SirT2.	WOWJIWFCOPZFGV-UHFFFAOYSA-N
28541	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Thompson T (2010)	20406950	223663	8606	Serdemetan	Serdemetan|1,4-Benzenediamine, N~1~-[2-(1H-indol-3-yl)ethyl]-N~4~-4-pyridinyl-|N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine|9161|ID6YB4W3V8	-	CHEMSPIDER	9784341	C21H20N4	small molecule	-	881202-45-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	CEGSUKYESLWKJP-UHFFFAOYSA-N
28542	110359	4194	RP11-430C7.1	MDM4	HDMX|MDMX|MRP1	9606	Homo sapiens	inhibitor	target	Wang H (2011)	21075910	223664	8619	7-(4-Methyl-1-piperazinyl)-4-nitro-2,1,3-benzoxadiazole 1-oxide	7-(4-Methylpiperazin-1-yl)-4-nitro-2,1,3-benzoxadiazole 1-oxide|2,1,3-Benzoxadiazole, 7-(4-methyl-1-piperazinyl)-4-nitro-, 1-oxide|7-(4-Methyl-1-piperazinyl)-4-nitro-2,1,3-benzoxadiazole 1-oxide	-	CHEMSPIDER	38890	C11H13N5O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	MWFZDJLPWDCQIL-UHFFFAOYSA-N
28543	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Issaeva N (2004)	15558054	144968	8582	RITA (NSC 652287)	(Furan-2,5-diyldithiene-5,2-diyl)dimethanol|2-Thiophenemethanol, 5,5'-(2,5-furandiyl)bis-|RITA (NSC 652287)|(2,5-Furandiyldi-5,2-thienediyl)dimethanol|[5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol	-	CHEMSPIDER	332269	C14H12O3S2	small molecule	-	213261-59-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	RITA binds to p53 and blocks the p53MDM2 interaction	KZENBFUSKMWCJF-UHFFFAOYSA-N
28544	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Ma T (2012)	22166212	220337	8613	Nutlin-3	NUTLIN-3, (-)-|NUTLIN 3|4-[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE|EX-A1359|CC-452|(-)-NUTLIN-3|NUTLIN3A|Q27166862|SB19406|HMS3649P17|C30H30CL2N4O4|AS-75148|1960AH|RAC-4-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|NUTLIN (3A)|BCP9001003|(RAC)-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL)(PIPERAZIN-1-YL)METHANONE|S8059|ZINC16051336|4-((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|4-[(4S,5R)-4,5-BIS-(4-CHLORO-PHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE|NUTLIN-3A CHIRAL|(4S,5R)-NUTLIN-3|2-PIPERAZINONE, 4-(((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-(4-METHOXY-2-(1-METHYLETHOXY)PHENYL)-1H-IMIDAZOL-1-YL)CARBONYL)-|4HG7|2603AH|A11501|4-[[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-2-PIPERAZINONE|SR-01000946691|W-5585|NUTLIN 3A|675576-98-4|UNII-53IA0V845C COMPONENT BDUHCSBCVGXTJM-WUFINQPMSA-N|NUTLIN-3A, >=98% (HPLC)|4-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4, 5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|NCGC00344347-05|NUTLIN-3A|SC-95163|UNII-L7C92IOE65|AKOS027422740|4J3E|4-[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(4-METHOXY-2-PROPAN-2-YLOXYPHENYL)-4,5-DIHYDROIMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE|HY-10029|CS-0296|SR-01000946691-1|NUTLIN-3A (CHIRAL)|L7C92IOE65|BDBM50229787	-	CHEMSPIDER	187530	C30H30Cl2N4O4	small molecule	-	548472-68-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	BDUHCSBCVGXTJM-UHFFFAOYSA-N
28568	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	De Cesare V (2018)	30017913	216529	786	Candesartan	2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid|Candesartan cilexetil|CV-11974|2-Ethoxy-1-(P-(O-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid|Blopress|2-Ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4ethyl]}-1H-benzimidazole-7-carboxylic acid	auro-candesartan|atacand plus|	DRUGBANK	DB00796	C24H20N6O3	small molecule	C09DB07|C09DA06|C09CA06	139481-59-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Positive hit in high screen assay validated by IC-50 determination.	HTQMVQVXFRQIKW-UHFFFAOYSA-N
28609	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Brand M (2019)	30595531	214853	8516	Bivalent ligand 76	protac 6|BSJ-03-123|Bivalent_ligand_76	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	BSJ-03-123|Standardized BVL Name: (CRBN:pomalidomide ---CDK6: palbociclib)	-
28613	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Rana S (2019)	30935795	215476	8516	Bivalent ligand 76	protac 6|BSJ-03-123|Bivalent_ligand_76	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: (CRBN:pomalidomide ---CDK6: palbociclib)	-
28616	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	Hines J (2019)	30385614	215621	8518	Bivalent ligand 78	A1874|Bivalent_ligand_78	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	117036	23476	-	BRD4	CAP|HUNK1|HUNKI|MCAP	9606	Homo sapiens	target	Standardized BVL Name: A1874(MDM2:idasanutlin --- BRD4:JQ1)	-
28621	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	target	Li Y (2019)	30525597	223612	8490	Bivalent ligand 82	MD-224|Bivalent_ligand_82	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MD-224 (CRBN:lenalidomide --- MDM2:MI-1061)	-
28625	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Burslem GM (2018)	29129716	211414	8492	Bivalent ligand 84	Compound 1|Bivalent_ligand_84	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 1 (VHL: compound 15 --- EGFR:lapatinib)	-
28627	108376	2064	-	ERBB2	CD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1	9606	Homo sapiens	degradation	target	Burslem GM (2018)	29129716	211414	8492	Bivalent ligand 84	Compound 1|Bivalent_ligand_84	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 1(VHL: compound 15 --- ERBB2:lapitinib)	-
28633	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Chen H (2019)	30901674	215477	8495	Bivalent ligand 87	Compound 2|Bivalent_ligand_87	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: Compound 2 (CRBN:pomalidomide ---BRAF: BRAF ligand)	-
28661	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Posternak G (2020)	32778845	223178	8501	Bivalent ligand 98	P4B|Bivalent_ligand_98	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: P4B(CRBN:pomalidomide --- BRAF:BI 882370)	-
28682	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	Zhao Q (2019)	30540295	223621	8505	Bivalent ligand 107	compound-3|Bivalent_ligand_107	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	106652	142	RP11-125A15.2	PARP1	ADPRT|ADPRT 1|ADPRT1|ARTD1|PARP|PARP-1|PPOL|pADPRT-1	9606	Homo sapiens	target	Standardized BVL Name: compound-3 (MDM2:nutlin-3 --- PARP1:niraparib)	-
28703	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Chen H (2019)	30901674	215477	8569	Bivalent ligand 116	compound 2|Bivalent_ligand_116	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 2 (CRBN:pomalidomide --- B-RAF:B-RAF ligand)	-
28749	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Huang HT (2018)	29129717	211728	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide --- CDK6:TL13-87)	-
28755	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Huang HT (2018)	29129717	211728	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide --- CDK4:TL13-87)	-
28837	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Banik SM (2020)	32728216	223640	8526	Bivalent ligand 136	Ab-2|Bivalent_ligand_136	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	LYTAC	Lysosome Targeting Chimera; structured as glycopeptide ligand--linker--target binding moiety; target degraded via endosome-lysosome system	109703	3482	-	IGF2R	CD222|CIMPR|M6P-R|MPR1|MPRI	9606	Homo sapiens	lysosome-targeting protein	Standardized BVL Name: Ab-2 (IGF2R:M6Pn glycopolypeptide ligand --- EGFR:cetuximab)	-
28879	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Sievers QL (2018)	30385546	212829	8560	Bivalent ligand 142	pomalidomide|Bivalent_ligand_142	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Full length protein degraded in vivo|Standardized BVL Name: (CRBN:pomalidomide ---IKZF1:pomalidomide)	-
28881	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Sievers QL (2018)	30385546	212829	8561	Bivalent ligand 143	lenalidomide|Bivalent_ligand_143	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Full length protein degraded in vivo|Standardized BVL Name: (CRBN:lenalidomide ---IKZF1:lenalidomide)	-
28891	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	degradation	target	Shan Y (2020)	32750566	223645	8563	Bivalent ligand 145	PROTAC 5|Bivalent_ligand_145	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 5(VHL:VH032 ---KDR:ABT-869)	-
28896	111105	5071	KB-152G3.1	PARK2	AR-JP|LPRS2|PDJ|PRKN	9606	Homo sapiens	degradation	recruited e3 ligase	Schiedel M (2020)	32672888	223648	8566	Bivalent ligand 148	chloroalkylated SirReal 11|Bivalent_ligand_148	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	HaloPROTAC	PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety--linker--HaloTag binding moiety; target degraded via UPS	116593	22933	-	SIRT2	SIR2|SIR2L|SIR2L2	9606	Homo sapiens	target	Standardized BVL Name: chloroalkylated SirReal 11 (HaloTag-PRKN--- SIRT2:SirReal3)	-
28937	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8476	Bivalent ligand 163	BSJ-02-162|Bivalent_ligand_163	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ02162 (CRBN:thalidomide --- CDK4:palbociclib)	-
28939	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8476	Bivalent ligand 163	BSJ-02-162|Bivalent_ligand_163	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ02162 (CRBN:thalidomide --- CDK6:palbociclib)	-
28941	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8481	Bivalent ligand 164	BSJ-01-152|Bivalent_ligand_164	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ01152 (CRBN:thalidomide --- CDK4:ribociclib)	-
28943	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8481	Bivalent ligand 164	BSJ-01-152|Bivalent_ligand_164	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ01152 (CRBN:thalidomide --- CDK6:ribociclib)	-
28945	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8482	Bivalent ligand 165	BSJ-01-184|Bivalent_ligand_165	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ01184 (CRBN:thalidomide --- CDK4:abemaciclib)	-
28947	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8482	Bivalent ligand 165	BSJ-01-184|Bivalent_ligand_165	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ01184 (CRBN:thalidomide --- CDK6:abemaciclib)	-
28951	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8479	Bivalent ligand 166	BSJ-01-187|Bivalent_ligand_166	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ01187 (CRBN:thalidomide --- CDK4:ribociclib)	-
28953	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8480	Bivalent ligand 167	YKL-06-102|Bivalent_ligand_167	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: YKL06102 (CRBN:thalidomide --- CDK6:palbociclib)	-
28955	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8479	Bivalent ligand 166	BSJ-01-187|Bivalent_ligand_166	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ01187 (CRBN:thalidomide --- IKZF1:ribociclib)	-
28957	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8480	Bivalent ligand 167	YKL-06-102|Bivalent_ligand_167	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: YKL06102 (CRBN:thalidomide --- IZKF1:palbociclib)	-
28959	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8476	Bivalent ligand 163	BSJ-02-162|Bivalent_ligand_163	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ02162 (CRBN:thalidomide --- IZKF1:palbociclib)	-
28967	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8473	Bivalent ligand 168	BSJ-03-204|Bivalent_ligand_168	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ03204 (CRBN:thalidomide --- CDK4:palbociclib)	-
28969	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8473	Bivalent ligand 168	BSJ-03-204|Bivalent_ligand_168	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ03204 (CRBN:thalidomide --- CDK6:palbociclib)	-
28971	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8474	Bivalent ligand 169	BSJ-04-132|Bivalent_ligand_169	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ04132 (CRBN:thalidomide --- CDK4:ribociclib)	-
28973	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Jiang B (2019)	30802347	223660	8472	Bivalent ligand 170	BSJ-03-123|Bivalent_ligand_170	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ03123 (CRBN:thalidomide --- CDK6:palbociclib)	-
29126	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Holzer P (2015)	26181851	224770	9193	Nvp-cgm097	ZINC253387855|(1S)-1-(4-CHLOROPHENYL)-6-METHOXY-2-[4-[METHYL-[[4-(4-METHYL-3-OXOPIPERAZIN-1-YL)CYCLOHEXYL]METHYL]AMINO]PHENYL]-7-PROPAN-2-YLOXY-1,4-DIHYDROISOQUINOLIN-3-ONE|(S)-1-(4-CHLOROPHENYL)-7-ISOPROPOXY-6-METHOXY-2-(4-[METHYL[4-(4-METHYL-3-OXOPIPERAZIN-1-YL)-TRANS-CYCLOHEXYLMETHYL]AMINO]PHENYL)-1,4-DIHYDRO-2H-ISOQUINOLIN-3-ONE|4UF6MSL0ZH|NVP-CGM-097|KS-00000TSY|CCG-270337|US9051279, 106|(1S)-1-(4-CHLOROPHENYL)-6-METHOXY-2-[4-(METHYL{[TRANS-4-(4-METHYL-3-OXOPIPERAZIN-1-YL)CYCLOHEXYL]METHYL}AMINO)PHENYL]-7-(PROPAN-2-YLOXY)-1,4-DIHYDROISOQUINOLIN-3(2H)-ONE|EX-A1059|CS-3138|HY-15954|NVP-CGM097 (CGM-097)|NVP-CGM097|Q27454942|NCGC00390552-01|W5747|4T4|NVP CGM097|(1S)-1-(4-CHLOROPHENYL)-6-METHOXY-2-{4-[METHYL({[(1R,4R)-4-(4-METHYL-3-OXOPIPERAZIN-1-YL)CYCLOHEXYL]METHYL})AMINO]PHENYL}-7-(PROPAN-2-YLOXY)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-ONE|C38H47CLN4O4|1313363-54-0|(1S)-1-(4-CHLOROPHENYL)-1,4-DIHYDRO-6-METHOXY-7-(1-METHYLETHOXY)-2-[4-[METHYL[[TRANS-4-(4-METHYL-3-OXO-1-PIPERAZINYL)CYCLOHEXYL]METHYL]AMINO]PHENYL]-3(2H)-ISOQUINOLINONE|CGM-097|(S)-1-(4-CHLOROPHENYL)-7-ISOPROPOXY-6-METHOXY-2-(4-(METHYL(((1R,4S)-4-(4-METHYL-3-OXOPIPERAZIN-1-YL)CYCLOHEXYL)METHYL)AMINO)PHENYL)-1,2-DIHYDROISOQUINOLIN-3(4H)-ONE|UNII-4UF6MSL0ZH|A16326|AS-75288|S7875|CGM097|J3.509.326E|CGM 097|BCP18308|AKOS030526402|BDBM162123	-	PUBCHEM	53240420	C38H47ClN4O4	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	CLRSLRWKONPSRQ-CPOWQTMSSA-N
29139	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Miyazaki M (2015)	25882531	224772	9206	[(2S,4R)-1-[(5R,6S)-5-(4-Chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-4-fluoropyrrolidin-2-yl]-[(6R)-6-ethyl-4,7-diazaspiro[2.5]octan-7-yl]methanone	BDBM50069632	-	PUBCHEM	46840822	C34H38Cl2F2N6O2S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	QUYOIFDRHGZSFZ-YABFKZQLSA-N
29140	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Miyazaki M (2015)	25882531	224772	9207	[(2S,4R)-1-[(5R,6S)-5-(4-Chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-4-fluoropyrrolidin-2-yl]-[(6S)-6-methyl-4,7-diazaspiro[2.5]octan-7-yl]methanone	[(2S,4R)-1-[(5R,6S)-5-(4-CHLORO-3-FLUOROPHENYL)-6-(6-CHLOROPYRIDIN-3-YL)-6-METHYL-3-PROPAN-2-YL-5H-IMIDAZO[2,1-B][1,3]THIAZOLE-2-CARBONYL]-4-FLUOROPYRROLIDIN-2-YL]-[(6S)-6-METHYL-4,7-DIAZASPIRO[2.5]OCTAN-7-YL]METHANONE|(6S)-7-[(4R)-1-{[(5R,6S)-5-(4-CHLORO-3-FLUOROPHENYL)-6-(6-CHLOROPYRIDIN-3-YL)-3-ISOPROPYL-6-METHYL-5,6-DIHYDROIMIDAZO[2,1-B][1,3]THIAZOL-2-YL]CARBONYL}-4-FLUORO-L-PROLYL]-6-METHYL-4,7-DIAZASPIRO[2.5]OCTANE|BDBM50069631	-	PUBCHEM	46840819	C33H36Cl2F2N6O2S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	OKIDBNYMCUVSLU-QSSUNTQZSA-N
29141	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Miyazaki M (2015)	25882531	224772	9208	[(2S,5R)-1-[(5R,6S)-5-(4-Chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-5-methylpyrrolidin-2-yl]-[(6S)-6-methyl-4,7-diazaspiro[2.5]octan-7-yl]methanone	BDBM50069630	-	PUBCHEM	87252803	C34H39Cl2FN6O2S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	KUZMUIBQNCSWPP-BYJYTBDMSA-N
29142	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Miyazaki M (2015)	25882531	224772	9209	[(2S,5R)-1-[(5R,6S)-5-(4-Chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-5-methylpyrrolidin-2-yl]-(4,7-diazaspiro[2.5]octan-7-yl)methanone	BDBM50069629	-	PUBCHEM	87252745	C33H37Cl2FN6O2S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	FZPRQVYQBJKIQG-KERGWKIMSA-N
29143	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Miyazaki M (2015)	25882531	224772	9210	[(2S,5R)-1-[(5R,6S)-5-(4-Chloro-3-fluorophenyl)-6-(4-chlorophenyl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-5-methylpyrrolidin-2-yl]-(4,7-diazaspiro[2.5]octan-7-yl)methanone	BDBM50069628	-	PUBCHEM	67058381	C34H38Cl2FN5O2S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	LIFXVTDIRXSOPW-ZNGXGWPMSA-N
29144	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Miyazaki M (2015)	25882531	224772	9211	[(2S,5R)-1-[(5R,6S)-5,6-Bis(4-chlorophenyl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-5-methylpyrrolidin-2-yl]-(4,7-diazaspiro[2.5]octan-7-yl)methanone	BDBM50069627	-	PUBCHEM	44596000	C34H39Cl2N5O2S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	XLBQSMBISPUIMT-MAMXRPNDSA-N
29145	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Miyazaki M (2015)	25882531	224772	9212	[(2S,5R)-1-[(5R,6S)-5,6-Bis(4-chlorophenyl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-5-methylpyrrolidin-2-yl]-(4-methyl-4,7-diazaspiro[2.5]octan-7-yl)methanone	BDBM50069626	-	PUBCHEM	67058380	C35H41Cl2N5O2S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	ZCAFJDRQRAWKAO-GRZVAKJNSA-N
29146	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Miyazaki M (2015)	25882531	224772	9213	[(2S,5R)-1-[(5R,6S)-5,6-Bis(4-chlorophenyl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-5-methylpyrrolidin-2-yl]-[(3R)-3,4-dimethylpiperazin-1-yl]methanone	(5R,6S)-5,6-BIS(4-CHLOROPHENYL)-2-[((2S,5R)-2-{[(3R)-3,4-DIMETHYLPIPERAZIN-1-YL]CARBONYL}-5-METHYLPYRROLIDIN-1-YL)CARBONYL]-3-ISOPROPYL-6-METHYL-5,6-DIHYDROIMIDAZO[2,1-B][1,3]THIAZOLE|[(2S,5R)-1-[(5R,6S)-5,6-BIS(4-CHLOROPHENYL)-6-METHYL-3-PROPAN-2-YL-5H-IMIDAZO[2,1-B][1,3]THIAZOLE-2-CARBONYL]-5-METHYLPYRROLIDIN-2-YL]-[(3R)-3,4-DIMETHYLPIPERAZIN-1-YL]METHANONE|BDBM50069625	-	PUBCHEM	58007373	C34H41Cl2N5O2S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	ZEYRMSIQYBSOGW-KBVCYFDGSA-N
29147	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Lawrence HR (2015)	25699576	224773	9214	BDBM98282	-	-	CHEMBL	CHEMBL2325940	C24H24N4O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	PILAMBNAJPBLFA-RWXRFDSASA-N
29148	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Lawrence HR (2015)	25699576	224773	9215	5-Chloro-2-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-N-[[(2S)-oxolan-2-yl]methyl]pyrimidine-2,4-diamine	BDBM50084465	-	PUBCHEM	117859438	C20H27ClN6O	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	MMJSYUQCKWEFRW-KRWDZBQOSA-N
29149	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Lawrence HR (2015)	25699576	224773	9216	5-Chloro-2-N-[4-(4-methylpiperazin-1-yl)phenyl]-4-N-[[(2R)-oxolan-2-yl]methyl]pyrimidine-2,4-diamine	J3.522.184K|N-[[(R)-TETRAHYDROFURAN-2-YL]METHYL]-5-CHLORO-2-[[4-(4-METHYL-1-PIPERAZINYL)PHENYL]AMINO]PYRIMIDINE-4-AMINE|5-CHLORO-2-N-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-4-N-[[(2R)-OXOLAN-2-YL]METHYL]PYRIMIDINE-2,4-DIAMINE|BDBM50084464	-	PUBCHEM	90479825	C20H27ClN6O	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	MMJSYUQCKWEFRW-QGZVFWFLSA-N
29150	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Lawrence HR (2015)	25699576	224773	5562	Bosutinib	SKI 606|Bosulif|4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile|Bosutinib|SKI-606|Bosutinib Monohydrate|BDBM4552	bosulif	DRUGBANK	DB06616	C26H29Cl2N5O3	small molecule	L01XE14	380843-75-4	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	UBPYILGKFZZVDX-UHFFFAOYSA-N
29151	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Lawrence HR (2015)	25699576	224773	1242	Dasatinib	Dasatinib (anh.)|Dasatinib|N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide|BMS dasatinib|Anhydrous dasatinib|dasatinib (anhydrous)|anh. dasatinib|Dasatinibum|BDBM13216	sprycel	DRUGBANK	DB01254	C22H26ClN7O2S	small molecule	L01XE06	302962-49-8	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	ZBNZXTGUTAYRHI-UHFFFAOYSA-N
29163	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Aguilar A (2014)	25496041	224775	9224	CID 70677271	MI-1061|4-((3'R,4'S,5'R)-6''-CHLORO-4'-(3-CHLORO-2-FLUOROPHENYL)-2''-OXODISPIRO[CYCLOHEXANE-1,2'-PYRROLIDINE-3',3''-INDOLINE]-5'-CARBOXAMIDO)BENZOIC ACID|HY-125858|CS-0102051|1410737-34-6|BDBM50041086	-	PUBCHEM	70677271	C30H26Cl2FN3O4	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	BIDSEXPFIMKDMF-LOLKONATSA-N
29164	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Aguilar A (2014)	25496041	224775	9225	BDBM50041085	-	-	CHEMBL	CHEMBL3355429	C28H30Cl2FN3O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	CQRICESTNDBKIY-KUGUZAOFSA-N
29165	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Aguilar A (2014)	25496041	224775	9226	CID 118720818	BDBM50041081	-	PUBCHEM	118720818	C27H30Cl2FN3O4	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	UKYBEEZQFSEMPW-LPJWUPNOSA-N
29166	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Aguilar A (2014)	25496041	224775	9227	BDBM50041075	-	-	CHEMBL	CHEMBL3355417	C30H34Cl2FN3O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	UVWMOYGSAUBCGS-WPUIHRAISA-N
29167	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Aguilar A (2014)	25496041	224775	9228	BDBM50041074	-	-	CHEMBL	CHEMBL3355416	C29H32Cl2FN3O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	QQOSBFYZJBKRMS-UAKSBLKBSA-N
29168	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Aguilar A (2014)	25496041	224775	9229	BDBM50041073	-	-	CHEMBL	CHEMBL3355415	C28H30Cl2FN3O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	HQXQIUHXDOQUSV-XLKFOPSHSA-N
29169	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Aguilar A (2014)	25496041	224775	9230	BDBM50041031	-	-	CHEMBL	CHEMBL3355411	C28H32Cl2FN3O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	IRTYMVBGDAJRNN-XLKFOPSHSA-N
29170	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Aguilar A (2014)	25496041	224775	9231	CID 71023165	US8629141, 15|BDBM112748	-	PUBCHEM	71023165	C29H33Cl2FN4O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	ZULOPCMLZWFEKU-ZLZBJJAKSA-N
29171	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Zhao Y (2015)	25396320	224776	8613	Nutlin-3	NUTLIN-3, (-)-|NUTLIN 3|4-[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE|EX-A1359|CC-452|(-)-NUTLIN-3|NUTLIN3A|Q27166862|SB19406|HMS3649P17|C30H30CL2N4O4|AS-75148|1960AH|RAC-4-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|NUTLIN (3A)|BCP9001003|(RAC)-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL)(PIPERAZIN-1-YL)METHANONE|S8059|ZINC16051336|4-((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|4-[(4S,5R)-4,5-BIS-(4-CHLORO-PHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE|NUTLIN-3A CHIRAL|(4S,5R)-NUTLIN-3|2-PIPERAZINONE, 4-(((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-(4-METHOXY-2-(1-METHYLETHOXY)PHENYL)-1H-IMIDAZOL-1-YL)CARBONYL)-|4HG7|2603AH|A11501|4-[[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-2-PIPERAZINONE|SR-01000946691|W-5585|NUTLIN 3A|675576-98-4|UNII-53IA0V845C COMPONENT BDUHCSBCVGXTJM-WUFINQPMSA-N|NUTLIN-3A, >=98% (HPLC)|4-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4, 5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|NCGC00344347-05|NUTLIN-3A|SC-95163|UNII-L7C92IOE65|AKOS027422740|4J3E|4-[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(4-METHOXY-2-PROPAN-2-YLOXYPHENYL)-4,5-DIHYDROIMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE|HY-10029|CS-0296|SR-01000946691-1|NUTLIN-3A (CHIRAL)|L7C92IOE65|BDBM50229787	-	CHEMSPIDER	187530	C30H30Cl2N4O4	small molecule	-	548472-68-0	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	BDUHCSBCVGXTJM-UHFFFAOYSA-N
29172	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Rew Y (2014)	25384157	224777	9232	Mdm2 inhibitor amg-232	AC-29027|1352066-68-2|ZINC103248035|COMPOUND 2 [PMID: 24456472]|SB17210|AMG 232|GTPL11133|C28H35CL2NO5S|HY-12296|2-((3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-((S)-1-(ISOPROPYLSULFONYL)-3-METHYLBUTAN-2-YL)-3-METHYL-2-OXOPIPERIDIN-3-YL)ACETIC ACID|KRT232|V2654|MDM2 INHIBITOR AMG-232|2-[(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-3-METHYL-1-[(2S)-3-METHYL-1-PROPAN-2-YLSULFONYLBUTAN-2-YL]-2-OXOPIPERIDIN-3-YL]ACETIC ACID|AMG232|AOB87308|3-IPERIDINEACETIC ACID, 5-(3-HLOROPHENYL)-6-(4-HLOROPHENYL)-3-ETHYL-1-(1S)-2-ETHYL-1-[(1-ETHYLETHYL)ULFONYL]ETHYL]ROPYL]-2-XO-, (3R,5R,6S)-|AMG-232|UNII-7R7G6EH5UL|CS-3282|DB15299|(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-3-METHYL-1-((1S)-2-METHYL-1-(((1-METHYLETHYL)SULFONYL)METHYL)PROPYL)-2-OXO-3-PIPERIDINEACETIC ACID|NCGC00387801-04|AS-17007|NCGC00387801-05|KRT-232|1447813-21-9|7R7G6EH5UL|BDBM50448947	-	PUBCHEM	58573469	C28H35Cl2NO5S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	DRLCSJFKKILATL-YWCVFVGNSA-N
29173	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Rew Y (2014)	25384157	224777	9233	4-[[2-[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]acetyl]amino]-2-methoxybenzoic acid	3UD|4WT2|US8952036, EX. 3|4-(2-((3R,5R,6S)-1-((S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL)-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL)ACETAMIDO)-2-METHOXYBENZOIC ACID|4-[[2-[(3R,5R,6S)-1-[(1S)-2-TERT-BUTYLSULFONYL-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL]AMINO]-2-METHOXYBENZOIC ACID|4-({[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETYL}AMINO)-2-METHOXYBENZOIC ACID|Q27454148|BDBM144638	-	PUBCHEM	77108133	C37H41Cl2FN2O7S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	QGOICCMBEDDFCI-NXQGQTBASA-N
29203	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Wang Y (2014)	25042256	224780	9251	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-morpholin-4-ylsulfonylethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	2-[(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-MORPHOLIN-4-YLSULFONYLETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETIC ACID|BDBM50053052	-	PUBCHEM	67999720	C29H34Cl2N2O6S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	JSZIUWBZPLMUNE-GCMXZSHTSA-N
29204	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Wang Y (2014)	25042256	224780	9252	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-piperidin-1-ylsulfonylethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	2-[(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-PIPERIDIN-1-YLSULFONYLETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETIC ACID|BDBM50053051	-	PUBCHEM	67998850	C30H36Cl2N2O5S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	HLRWFQSMFDJFQQ-QXMDYEBFSA-N
29205	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Wang Y (2014)	25042256	224780	9253	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-(methylsulfamoyl)ethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	2-[(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(METHYLSULFAMOYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETIC ACID|BDBM50053045	-	PUBCHEM	68000050	C26H30Cl2N2O5S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	TUDCVMKUXPXOII-HLMLHLEXSA-N
29206	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Wang Y (2014)	25042256	224780	9254	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-(propan-2-ylsulfamoyl)ethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	2-[(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(1S)-1-CYCLOPROPYL-2-(PROPAN-2-YLSULFAMOYL)ETHYL]-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETIC ACID|BDBM50053040	-	PUBCHEM	68000097	C28H34Cl2N2O5S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	OLQSAQIIKIWIRZ-YWCVFVGNSA-N
29212	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Ma Y (2014)	24900882	224782	9260	[(2R,3S)-2-(2-Hydroxyethyl)-3-[4-[2-(2-methoxyethoxy)phenyl]piperazine-1-carbonyl]-3-[4-(trifluoromethyl)phenoxy]piperidin-1-yl]-[4-(trifluoromethyl)pyridin-3-yl]methanone;hydrochloride	BDBM50020151	-	PUBCHEM	90644648	C35H39ClF6N4O6	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	GAWXPLJRMGISPF-AAYBCKPTSA-N
29213	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Ma Y (2014)	24900882	224782	9261	[(2R,3S)-2-(2,3-Dihydroxypropyl)-3-[4-[2-(2-methoxyethoxy)phenyl]piperazine-1-carbonyl]-3-[4-(trifluoromethyl)phenoxy]piperidin-1-yl]-[4-(trifluoromethyl)pyridin-3-yl]methanone;hydrochloride	BDBM50020150	-	PUBCHEM	90644647	C36H41ClF6N4O7	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	QLKVYUYEIZLSOY-QAJMXTGNSA-N
29214	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Ma Y (2014)	24900882	224782	9262	[(2R,3S)-3-[4-[2-(2-Methoxyethoxy)phenyl]piperazine-1-carbonyl]-2-propyl-3-[4-(trifluoromethyl)phenoxy]piperidin-1-yl]-[4-(trifluoromethyl)pyridin-3-yl]methanone;hydrochloride	BDBM50020149	-	PUBCHEM	90644646	C36H41ClF6N4O5	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	YOTYTBNHWCLYIW-BRMBYNPVSA-N
29215	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Ma Y (2014)	24900882	224782	9263	[(2R,3S)-3-[4-[2-(2-Methoxyethoxy)phenyl]piperazine-1-carbonyl]-2-prop-2-enyl-3-[4-(trifluoromethyl)phenoxy]piperidin-1-yl]-[4-(trifluoromethyl)pyridin-3-yl]methanone	BDBM50001929	-	PUBCHEM	23642310	C36H38F6N4O5	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	QKOYVKQWXLFSPH-FJQKOURKSA-N
29216	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9264	2-[1-(3-Chloro-2-fluorophenyl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazol-4-yl]-5-methyl-1,3,4-oxadiazole	2-[1-(3-CHLORO-2-FLUOROPHENYL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOL-4-YL]-5-METHYL-1,3,4-OXADIAZOLE|BDBM50012598	-	PUBCHEM	67031670	C24H20Cl2F2N4O	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	WSYHJRPECYYALB-UHFFFAOYSA-N
29217	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9265	1-(3-Chloro-2-fluorophenyl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazole-4-carboxamide	1-(3-CHLORO-2-FLUOROPHENYL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOLE-4-CARBOXAMIDE|BDBM50012597	-	PUBCHEM	67032018	C22H19Cl2F2N3O	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	WCIBRTOQTDTZEH-UHFFFAOYSA-N
29218	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9266	1-(5-Chloro-2-methylphenyl)-5-(3-chlorophenyl)-2-phenylimidazole-4-carboxylic acid	1-(5-CHLORO-2-METHYLPHENYL)-5-(3-CHLOROPHENYL)-2-PHENYLIMIDAZOLE-4-CARBOXYLIC ACID|BDBM50012596	-	PUBCHEM	67035866	C23H16Cl2N2O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	HGVSKSDYMUWDDZ-UHFFFAOYSA-N
29219	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9267	1-(5-Chloro-2-Methylphenyl)-5-(3-Chlorophenyl)-2-(3-Methylphenyl)-1h-Imidazole-4-Carboxylic Acid	1-(5-CHLORO-2-METHYLPHENYL)-5-(3-CHLOROPHENYL)-2-(3-METHYLPHENYL)IMIDAZOLE-4-CARBOXYLIC ACID|4OQ3|Q27453318|2V8|1-(5-CHLORO-2-METHYLPHENYL)-5-(3-CHLOROPHENYL)-2-(3-METHYLPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID|BDBM50012595	-	PUBCHEM	50996417	C24H18Cl2N2O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	UYJZPBBJELZWKZ-UHFFFAOYSA-N
29220	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9268	1-(3-Chloro-2-fluorophenyl)-5-(3-chlorophenyl)-2-phenylimidazole-4-carboxylic acid	1-(3-CHLORO-2-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-2-PHENYLIMIDAZOLE-4-CARBOXYLIC ACID|BDBM50012594	-	PUBCHEM	67035746	C22H13Cl2FN2O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	BWKUHDIFHWGKSW-UHFFFAOYSA-N
29221	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9269	2-[2-[4-(5-Amino-1,3,4-oxadiazol-2-yl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazol-1-yl]-4-chloro-3-fluorophenyl]-N-phenylacetamide	2-[2-[4-(5-AMINO-1,3,4-OXADIAZOL-2-YL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOL-1-YL]-4-CHLORO-3-FLUOROPHENYL]-N-PHENYLACETAMIDE|BDBM50012593	-	PUBCHEM	67954180	C31H26Cl2F2N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	LVTCZQLXJGEKOF-UHFFFAOYSA-N
29222	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9270	5-[1-(3-Chloro-2-fluorophenyl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazol-4-yl]-1,3,4-oxadiazol-2-amine	5-[1-(3-CHLORO-2-FLUOROPHENYL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOL-4-YL]-1,3,4-OXADIAZOL-2-AMINE|BDBM50012592	-	PUBCHEM	67954546	C23H19Cl2F2N5O	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	XPRXKGPGGKKGGT-UHFFFAOYSA-N
29223	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9271	2-[2-[4-(5-Amino-1,3,4-oxadiazol-2-yl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazol-1-yl]-4-chloro-3-fluorophenyl]-N-methylacetamide	2-[2-[4-(5-AMINO-1,3,4-OXADIAZOL-2-YL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOL-1-YL]-4-CHLORO-3-FLUOROPHENYL]-N-METHYLACETAMIDE|2-{2-[4-(5-AMINO-[1,3,4]OXADIAZOL-2-YL)-5-(3-CHLORO-4-FLUORO-PHENYL)-2-CYCLOHEXYL-IMIDAZOL-1-YL]-4-CHLORO-3-FLUORO-PHENYL}-N-METHYL-ACETAMIDE|BDBM50012591	-	PUBCHEM	67032045	C26H24Cl2F2N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	FXKYGUQUTHFCIZ-UHFFFAOYSA-N
29224	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9272	1-(3-Chloro-2-fluorophenyl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazole-4-carboxylic acid	1-(3-CHLORO-2-FLUOROPHENYL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOLE-4-CARBOXYLIC ACID|BDBM50012590	-	PUBCHEM	67954173	C22H18Cl2F2N2O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	OKZRWZNDCUYSPD-UHFFFAOYSA-N
29225	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9273	5-[1-(3-Chloro-2-fluorophenyl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazol-4-yl]-2H-tetrazole	5-[1-(3-CHLORO-2-FLUOROPHENYL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOL-4-YL]-2H-TETRAZOLE|BDBM50012589	-	PUBCHEM	67032499	C22H18Cl2F2N6	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	APOKXFGOAIBPAE-UHFFFAOYSA-N
29226	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9274	1-(3-Chloro-2-fluorophenyl)-5-(3-chloro-4-fluorophenyl)-2-phenylimidazole-4-carboxylic acid	1-(3-CHLORO-2-FLUOROPHENYL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-PHENYLIMIDAZOLE-4-CARBOXYLIC ACID|BDBM50012588	-	PUBCHEM	67954174	C22H12Cl2F2N2O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	FQIJHXGZFVSBLN-UHFFFAOYSA-N
29227	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9275	2-[2-[4-(5-Amino-1,3,4-oxadiazol-2-yl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazol-1-yl]-4-chloro-3-fluorophenyl]-N-tert-butylacetamide	2-[2-[4-(5-AMINO-1,3,4-OXADIAZOL-2-YL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOL-1-YL]-4-CHLORO-3-FLUOROPHENYL]-N-TERT-BUTYLACETAMIDE|BDBM50012587	-	PUBCHEM	60167943	C29H30Cl2F2N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	SZZSUOGVLVLJPR-UHFFFAOYSA-N
29228	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Vaupel A (2014)	24704029	224783	9276	2-[2-[4-(5-Amino-1,3,4-oxadiazol-2-yl)-5-(3-chloro-4-fluorophenyl)-2-cyclohexylimidazol-1-yl]-4-chloro-3-fluorophenyl]-N-cyclohexylacetamide	2-[2-[4-(5-AMINO-1,3,4-OXADIAZOL-2-YL)-5-(3-CHLORO-4-FLUOROPHENYL)-2-CYCLOHEXYLIMIDAZOL-1-YL]-4-CHLORO-3-FLUOROPHENYL]-N-CYCLOHEXYLACETAMIDE|BDBM50012586	-	PUBCHEM	67034825	C31H32Cl2F2N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	SMUUKZTVPGSBEE-UHFFFAOYSA-N
29229	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Pan W (2014)	24656661	224784	8613	Nutlin-3	NUTLIN-3, (-)-|NUTLIN 3|4-[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE|EX-A1359|CC-452|(-)-NUTLIN-3|NUTLIN3A|Q27166862|SB19406|HMS3649P17|C30H30CL2N4O4|AS-75148|1960AH|RAC-4-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|NUTLIN (3A)|BCP9001003|(RAC)-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL)(PIPERAZIN-1-YL)METHANONE|S8059|ZINC16051336|4-((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|4-[(4S,5R)-4,5-BIS-(4-CHLORO-PHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE|NUTLIN-3A CHIRAL|(4S,5R)-NUTLIN-3|2-PIPERAZINONE, 4-(((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-(4-METHOXY-2-(1-METHYLETHOXY)PHENYL)-1H-IMIDAZOL-1-YL)CARBONYL)-|4HG7|2603AH|A11501|4-[[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-2-PIPERAZINONE|SR-01000946691|W-5585|NUTLIN 3A|675576-98-4|UNII-53IA0V845C COMPONENT BDUHCSBCVGXTJM-WUFINQPMSA-N|NUTLIN-3A, >=98% (HPLC)|4-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4, 5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|NCGC00344347-05|NUTLIN-3A|SC-95163|UNII-L7C92IOE65|AKOS027422740|4J3E|4-[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(4-METHOXY-2-PROPAN-2-YLOXYPHENYL)-4,5-DIHYDROIMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE|HY-10029|CS-0296|SR-01000946691-1|NUTLIN-3A (CHIRAL)|L7C92IOE65|BDBM50229787	-	CHEMSPIDER	187530	C30H30Cl2N4O4	small molecule	-	548472-68-0	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	BDUHCSBCVGXTJM-UHFFFAOYSA-N
29230	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Pan W (2014)	24656661	224784	9263	[(2R,3S)-3-[4-[2-(2-Methoxyethoxy)phenyl]piperazine-1-carbonyl]-2-prop-2-enyl-3-[4-(trifluoromethyl)phenoxy]piperidin-1-yl]-[4-(trifluoromethyl)pyridin-3-yl]methanone	BDBM50001929	-	PUBCHEM	23642310	C36H38F6N4O5	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	QKOYVKQWXLFSPH-FJQKOURKSA-N
29252	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Gonzalez AZ (2014)	24601644	224786	9297	2-[2-[[(3R,5R,6S)-1-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl]methyl]-1,3-thiazol-5-yl]acetic acid	(2-{[(3R,5R,6S)-1-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(4-CHLORO-3-FLUOROPHENYL)-5-(3-CHLOROPHENYL)-3-METHYL-2-OXOPIPERIDIN-3-YL]METHYL}-1,3-THIAZOL-5-YL)ACETIC ACID|Q27453278|AM-6761|2U0|4ODE|BDBM50008748	-	PUBCHEM	73386675	C33H37Cl2FN2O5S2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	HNLHOKSDTBAERS-CWIPYCOQSA-N
29253	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Gonzalez AZ (2014)	24548297	224787	9298	2-[(2R,5R,6R)-4-[(1S)-2-Tert-butylsulfonyl-1-cyclopropylethyl]-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-oxomorpholin-2-yl]acetic acid	Q27453272|CS-0012311|AM-8735|[(2R,5R,6R)-4-[(1S)-2-(TERT-BUTYLSULFONYL)-1-CYCLOPROPYLETHYL]-6-(3-CHLOROPHENYL)-5-(4-CHLOROPHENYL)-3-OXOMORPHOLIN-2-YL]ACETIC ACID|4OBA|2TW|2-[(2R,5R,6R)-4-[(1S)-2-TERT-BUTYLSULFONYL-1-CYCLOPROPYLETHYL]-6-(3-CHLOROPHENYL)-5-(4-CHLOROPHENYL)-3-OXOMORPHOLIN-2-YL]ACETIC ACID|HY-12734|BDBM50007638	-	PUBCHEM	71544420	C27H31Cl2NO6S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	ZTMSSDQFJNEUNG-WMMXXEOUSA-N
29254	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Sun D (2014)	24456472	224788	9232	Mdm2 inhibitor amg-232	AC-29027|1352066-68-2|ZINC103248035|COMPOUND 2 [PMID: 24456472]|SB17210|AMG 232|GTPL11133|C28H35CL2NO5S|HY-12296|2-((3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-((S)-1-(ISOPROPYLSULFONYL)-3-METHYLBUTAN-2-YL)-3-METHYL-2-OXOPIPERIDIN-3-YL)ACETIC ACID|KRT232|V2654|MDM2 INHIBITOR AMG-232|2-[(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-3-METHYL-1-[(2S)-3-METHYL-1-PROPAN-2-YLSULFONYLBUTAN-2-YL]-2-OXOPIPERIDIN-3-YL]ACETIC ACID|AMG232|AOB87308|3-IPERIDINEACETIC ACID, 5-(3-HLOROPHENYL)-6-(4-HLOROPHENYL)-3-ETHYL-1-(1S)-2-ETHYL-1-[(1-ETHYLETHYL)ULFONYL]ETHYL]ROPYL]-2-XO-, (3R,5R,6S)-|AMG-232|UNII-7R7G6EH5UL|CS-3282|DB15299|(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-3-METHYL-1-((1S)-2-METHYL-1-(((1-METHYLETHYL)SULFONYL)METHYL)PROPYL)-2-OXO-3-PIPERIDINEACETIC ACID|NCGC00387801-04|AS-17007|NCGC00387801-05|KRT-232|1447813-21-9|7R7G6EH5UL|BDBM50448947	-	PUBCHEM	58573469	C28H35Cl2NO5S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	DRLCSJFKKILATL-YWCVFVGNSA-N
29255	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Sun D (2014)	24456472	224788	9299	2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid	Q27451341|AM-8553|{(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(2S,3S)-2-HYDROXYPENTAN-3-YL]-3-METHYL-2-OXOPIPERIDIN-3-YL}ACETIC ACID|2-[(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-[(2S,3S)-2-HYDROXYPENTAN-3-YL]-3-METHYL-2-OXOPIPERIDIN-3-YL]ACETIC ACID|2-((3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-((2S,3S)-2-HYDROXYPENTAN-3-YL)-3-METHYL-2-OXOPIPERIDIN-3-YL)ACETIC ACID|0R3|BDBM50388626	-	PUBCHEM	56965957	C25H29Cl2NO4	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	YUALYRLIFVPOHL-VPLUBSIMSA-N
29256	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Huang Q (2014)	24432909	224789	9300	Unii-76pnd635L1	PF-06439015|(2R)-2-[5-[6-AMINO-5-[(1R)-1-[5-FLUORO-2-(TRIAZOL-2-YL)PHENYL]ETHOXY]PYRIDIN-3-YL]-4-METHYL-1,3-THIAZOL-2-YL]PROPANE-1,2-DIOL.|(2R)-2-[5-[6-AMINO-5-[(1R)-1-[5-FLUORO-2-(TRIAZOL-2-YL)PHENYL]ETHOXY]PYRIDIN-3-YL]-4-METHYL-1,3-THIAZOL-2-YL]PROPANE-1,2-DIOL|4CD0|(2R)-2-(5-(6-AMINO-5-((1R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL)ETHOXY)-3-PYRIDINYL)-4-METHYL-2-THIAZOLYL)-1,2-PROPANEDIOL|1549629-82-4|AWJ|P-355|Q27076827|76PND635L1|ZINC98050687|1,2-PROPANEDIOL, 2-(5-(6-AMINO-5-((1R)-1-(5-FLUORO-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL)ETHOXY)-3-PYRIDINYL)-4-METHYL-2-THIAZOLYL)-, (2R)-|PF 06439015|COMPOUND 8E [PMID: 24432909]|GTPL8137|NCGC00485046-01|UNII-76PND635L1|BDBM50448785	-	PUBCHEM	72710568	C22H23FN6O3S	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	DIXMBHMNEHPFCX-MCMMXHMISA-N
29280	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Karaman MW (2008)	18183025	224791	9308	Midostaurin	CCG-101288|SB16639|HY-10230|HMS3229K17|CGP 41 251|ZINC100013130|MIDOSTAURIN(PKC412)|PKC 412|CGP 41251|N-[(2S,3R,4R,6R)-3-METHOXY-2-METHYL-16-OXO-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8,10,12,14(28),15(19),20(27),21,23,25-NONAEN-4-YL]-N-METHYLBENZAMIDE|RYDAPT (TN)|PKC412|[9S-(9?,10?,11?,13?)]-N-(2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-1-OXO-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-11-YL)-N-METHYLBENZAMIDE|ACN-036840|4'-N-BENZOYLSTAUROSPORINE|BENZOYLSTAUROSPORINE|CGP-41251|MIDOSTAURIN [USAN:INN]|EX-A1741|N-BENZOYLSTAUROSPORINE|120685-11-2|D05029|CGP 41231|Q6842945|BRD-K13646352-001-01-2|DB06595|MIDOSTAURIN (JAN/USAN/INN)|CS-3331|NCGC00484987-03|Z-3116|N-[(5S,6R,7R,9R)-6-METHOXY-5-METHYL-14-OXO-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-7-YL]-N-METHYLBENZAMIDE|CGP-41521|ID912S5VON|AKOS024457372|PKC-412|UNII-ID912S5VON|NCGC00241102-02|GTPL5702|NVP-PKC412|J-004379|RYDAPT|MIDOSTAURIN|S8064|NCGC00241102-01|BDBM50326053	-	PUBCHEM	9829523	C35H30N4O4	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	BMGQWWVMWDBQGC-IIFHNQTCSA-N
29281	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Karaman MW (2008)	18183025	224791	1934	Staurosporine	2GCD|BCPP000063|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-METHYLAMINO-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-09|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- (9CI)|ANTIBIOTIC AM-2282|EX-A1777|9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)-BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S-(9ALPHA,10BETA,11BETA,13ALPHA)-|HMS3650B17|NCGC00162400-06|H88EPA0A3N|8-METHOXY-9-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-16-OL|BRD-K17953061-001-02-8|62996-74-1|BRD-K17953061-001-11-9|109189-95-9|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8,10,12,14(28),15(19),20(27),21,23,25-NONAEN-16-ONE|1U59|CCG-208052|STAUROSPORINE & TUMOR NECROSIS FACTOR (TNF)|NCGC00162400-02|2DQ7|MEGXM0_000307|1NVR|STAUROSPORINE;9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)-|BRD-K17953061-001-05-1|NCGC00162400-03|7158-EP2289893A1|8,12-EPOXY-1H,8H-2,7B,12A-TRIAZADIBENZO(A,G)CYCLONONA(CDE)TRINDEN-1-ONE, 2,3,9,10,11,12-HEXAHYDRO-9-METHOXY-8-METHYL-10-(METHYLAMINO)-, (8ALPHA,9BETA,10BETA,12ALPHA)-(+)-|CGP 39360|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8(13),9,11,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|AM-2282|ANTIBIOTIC AM 2282|1XJD|STAUROSPORIN|STAUROSPORINE & TNF|7158-EP2311842A2|STAUROSPORIN, 4|DB02010|METHOXY-METHYL-(METHYLAMINO)[?]ONE|NCGC00162400-01|GNF-PF-1389|7158-EP2292617A1|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, [9S-(9ALPHA,10BETA,11BETA,13ALPHA)]-|ANTIBIOTIC 230|7158-EP2308855A1|ALKALOID AM-2282 FROM STREPTOMYCES|ST50826371|1STC|HY-15141|MOLMAP_000047|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-04|(+)-STAUROSPORINE|GTPL346|7158-EP2311809A1|Q5957181|CS-2716|STAUROSPORINE, 8|AKOS015897119|BIO1_000753|BRD-K17953061-001-04-4|SR-00000001485-4|STAUROSPORINE|7158-EP2308883A1|BRD-K17953061-001-10-1|NCGC00162400-05|[9S-(9?,10?,11?,13?)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE|LS-64042|CBIOL_001978|1SM2|1Q3D|BIO1_000264|1YHS|ZINC3814434|S1421|SR-00000001485|UNII-H88EPA0A3N|7158-EP2270008A1|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- & TUMOR NECROSIS FACTOR (TNF)|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO [12.12.2.1<2,6>.0<7,28>.0<8,13>.0<15,19>.0<20,27>.0<21,26>]NONACOSA-8(13),9,11 ,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|QTL1_000078|HMS1990J07|BIO1_001242|1XBC|DTXSID30911019|CCRIS 3272|BSPBIO_001146|BRD-K17953061-001-08-5|BDBM2579	-	DRUGBANK	DB02010	C28H26N4O3	small molecule	-	62996-74-1	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	HKSZLNNOFSGOKW-UCBFMKAXSA-N
29282	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Karaman MW (2008)	18183025	224791	1242	Dasatinib	Dasatinib (anh.)|Dasatinib|N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide|BMS dasatinib|Anhydrous dasatinib|dasatinib (anhydrous)|anh. dasatinib|Dasatinibum|BDBM13216	sprycel	DRUGBANK	DB01254	C22H26ClN7O2S	small molecule	L01XE06	302962-49-8	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	ZBNZXTGUTAYRHI-UHFFFAOYSA-N
29290	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Wells JA (2007)	18075579	224792	8613	Nutlin-3	NUTLIN-3, (-)-|NUTLIN 3|4-[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE|EX-A1359|CC-452|(-)-NUTLIN-3|NUTLIN3A|Q27166862|SB19406|HMS3649P17|C30H30CL2N4O4|AS-75148|1960AH|RAC-4-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|NUTLIN (3A)|BCP9001003|(RAC)-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL)(PIPERAZIN-1-YL)METHANONE|S8059|ZINC16051336|4-((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|4-[(4S,5R)-4,5-BIS-(4-CHLORO-PHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE|NUTLIN-3A CHIRAL|(4S,5R)-NUTLIN-3|2-PIPERAZINONE, 4-(((4S,5R)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-(4-METHOXY-2-(1-METHYLETHOXY)PHENYL)-1H-IMIDAZOL-1-YL)CARBONYL)-|4HG7|2603AH|A11501|4-[[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-4,5-DIHYDRO-2-[4-METHOXY-2-(1-METHYLETHOXY)PHENYL]-1H-IMIDAZOL-1-YL]CARBONYL]-2-PIPERAZINONE|SR-01000946691|W-5585|NUTLIN 3A|675576-98-4|UNII-53IA0V845C COMPONENT BDUHCSBCVGXTJM-WUFINQPMSA-N|NUTLIN-3A, >=98% (HPLC)|4-(4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4, 5-DIHYDRO-1H-IMIDAZOLE-1-CARBONYL)PIPERAZIN-2-ONE|NCGC00344347-05|NUTLIN-3A|SC-95163|UNII-L7C92IOE65|AKOS027422740|4J3E|4-[(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-(4-METHOXY-2-PROPAN-2-YLOXYPHENYL)-4,5-DIHYDROIMIDAZOLE-1-CARBONYL]PIPERAZIN-2-ONE|HY-10029|CS-0296|SR-01000946691-1|NUTLIN-3A (CHIRAL)|L7C92IOE65|BDBM50229787	-	CHEMSPIDER	187530	C30H30Cl2N4O4	small molecule	-	548472-68-0	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	BDUHCSBCVGXTJM-UHFFFAOYSA-N
29291	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Wells JA (2007)	18075579	224792	9309	DI-Chloro-benzo-diazepine	BENZODIAZEPINEDIONE, 1|(2S)-(4-CHLOROPHENYL)[(3S)-3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ETHANOIC ACID|BMCL163310 COMPOUND 1|Q27459367|TDP-222669|(4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID|DIZ|(2S)-2-(4-CHLOROPHENYL)-2-[(3S)-3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,3-DIHYDRO-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID|1T4E|JNJ-38732382|DI-CHLORO-BENZO-DIAZEPINE|BDBM31285	-	PUBCHEM	656933	C23H15Cl2IN2O4	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	HQEQUYKKMMKSSX-PMACEKPBSA-N
29300	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	unknown	target	Grasberger BL (2005)	15715460	224796	9309	DI-Chloro-benzo-diazepine	BENZODIAZEPINEDIONE, 1|(2S)-(4-CHLOROPHENYL)[(3S)-3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ETHANOIC ACID|BMCL163310 COMPOUND 1|Q27459367|TDP-222669|(4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID|DIZ|(2S)-2-(4-CHLOROPHENYL)-2-[(3S)-3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,3-DIHYDRO-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID|1T4E|JNJ-38732382|DI-CHLORO-BENZO-DIAZEPINE|BDBM31285	-	PUBCHEM	656933	C23H15Cl2IN2O4	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	HQEQUYKKMMKSSX-PMACEKPBSA-N
29440	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Smith CR (2015)	26087137	224836	9427	4-Amino-8-(5-Methyl-1h-Indazol-6-Yl)cinnoline-3-Carboxamide	4-AMINO-8-(5-METHYL-1H-INDAZOL-6-YL)CINNOLINE-3-CARBOXAMIDE|4-AMINO-8-(5-METHYL-1H-INDAZOLE-6-YL)CINNOLINE-3-CARBOXAMIDE|4L6|Q27454796|BDBM50097393	-	PUBCHEM	71765510	C17H14N6O	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	PTHVKCSYXICMAR-UHFFFAOYSA-N
29591	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Johnson TW (2014)	24819116	224868	9558	Lorlatinib	PF06463922(LORLATINIB)|BCP10287|ZINC98208524|PFE-PKIS 10|D11012|(10R)-7-AMINO-12-FLUORO-10,15,16,17-TETRAHYDRO-2,10,16-TRIMETHYL-15-OXO-2H-4,8-METHENOPYRAZOLO[4,3-H][2,5,11]BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE|HY-12215|7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE|CS-3983|S7536|DB12130|AK175603|PF 06463922|GTPL7476|PF-06463922 LORLATINIB|LORLATINIB,PF-06463922|LORLATINIBUM|OSP71S83EU|LORATINIB|PF06463922|PF-06463922|EX-A828|UNII-OSP71S83EU|A14207|LORVIQUA|LORBRENA|(10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO[4,3-H][2,5,11]BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE|1454846-35-5|NCGC00386417-02|C21H19FN6O2|J-690185|(10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO[4,3-H][2,5,11]-BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE|4CLI|2H-4,8-METHENOPYRAZOLO(4,3-H)(2,5,11)BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE, 7-AMINO-12-FLUORO-10,15,16,17-TETRAHYDRO-2,10,16-TRIMETHYL-15-OXO-, (10R)-|CCG-268718|LORLATINIB [USAN:INN]|AKOS027250753|LORBRENA (TN)|LORLATINIB (JAN/USAN/INN)|KS-00000T6C|2H-4,8-METHENOPYRAZOLO[4,3-H][2,5,11]BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE, 7-AMINO-12-FLUORO-10,15,16,17-TETRAHYDRO-2,10,16-TRIMETHYL-15-OXO-, (10R)-|Q27285820|(10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15-OXO-10,15,16,17-TETRAHYDRO-2H-4,8-METHENOPYRAZOLO[4,3-H][2,5,11]BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE|MFCD28144520|4CLJ|2641AH|NCGC00386417-13|LORLATINIB|BDBM50018830	-	PUBCHEM	71731823	C21H19FN6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	IIXWYSCJSQVBQM-LLVKDONJSA-N
29656	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9597	6-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-N-[[(2S)-oxolan-2-yl]methyl]-5-phenylfuro[2,3-d]pyrimidin-4-amine	6-[4-[(4-METHYLPIPERAZIN-1-YL)METHYL]PHENYL]-N-[[(2S)-OXOLAN-2-YL]METHYL]-5-PHENYLFURO[2,3-D]PYRIMIDIN-4-AMINE|(S)-6-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)PHENYL)-5-PHENYL-N-((TETRAHYDROFURAN-2-YL)METHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204590	-	PUBCHEM	44438320	C29H33N5O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	IYUXAJHPXXWFQO-DEOSSOPVSA-N
29657	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9598	Aim-100	5,6-DIPHENYL-4-[(S)-(TETRAHYDROFURAN-2-YL)-METHYL]AMINO FURO[2,3-D]PYRIMIDINE|AIM-100|873305-35-2|EX-A3635|MLS006010340|(S)-5,6-DIPHENYL-N-((TETRAHYDROFURAN-2-YL)METHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|S2212|AIM 100|5,6-DIPHENYL-N-[[(2S)-TETRAHYDRO-2-FURANYL]METHYL]FURO[2,3-D]PYRIMIDIN-4-AMINE|ZINC28879084|N-[[(2S)-OXOLAN-2-YL]METHYL]-5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-AMINE|AKOS024458428|W-5920|NCGC00347279-01|HY-15290|NCGC00347279-04|DTXSID20467671|5,6-DIPHENYL-N-[[(2S)-TETRAHYDROFURAN-2-YL]METHYL]FURO[2,3-D]PYRIMIDIN-4-AMINE|SMR004701402|3426AH|AIM 100;AIM100|CS-0702|BDBM50204589	-	PUBCHEM	11501591	C23H21N3O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	XNFHHOXCDUAYSR-SFHVURJKSA-N
29658	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9599	6-[4-[2-(Dimethylamino)ethoxy]phenyl]-N-[[(2S)-oxolan-2-yl]methyl]-5-phenylfuro[2,3-d]pyrimidin-4-amine	6-[4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-N-[[(2S)-OXOLAN-2-YL]METHYL]-5-PHENYLFURO[2,3-D]PYRIMIDIN-4-AMINE|{6-[4-(2-DIMETHYLAMINO-ETHOXY)-PHENYL]-5-PHENYL-FURO[2,3-D]PYRIMIDIN-4-YL}-(TETRAHYDRO-FURAN-2-(S)-YL-METHYL)-AMINE|(S)-6-(4-(2-(DIMETHYLAMINO)ETHOXY)PHENYL)-5-PHENYL-N-((TETRAHYDROFURAN-2-YL)METHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204587	-	PUBCHEM	44438318	C27H30N4O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	XNSZHQUDPHATEN-QFIPXVFZSA-N
29659	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9600	6-[3-Methoxy-4-(2-piperidin-1-ylethoxy)phenyl]-N-[[(2S)-oxolan-2-yl]methyl]-5-phenylfuro[2,3-d]pyrimidin-4-amine	6-(3-METHOXY-4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-5-PHENYL-N-(((S)-TETRAHYDROFURAN-2-YL)METHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|6-[3-METHOXY-4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-N-[[(2S)-OXOLAN-2-YL]METHYL]-5-PHENYLFURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204586	-	PUBCHEM	11519350	C31H36N4O4	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	IOSKHROQBBQEOB-DEOSSOPVSA-N
29660	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9601	N-[[(2S)-Oxolan-2-yl]methyl]-5-phenyl-6-[4-(2-pyrrolidin-1-ylethoxy)phenyl]furo[2,3-d]pyrimidin-4-amine	N-[[(2S)-OXOLAN-2-YL]METHYL]-5-PHENYL-6-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-4-AMINE|(S)-5-PHENYL-6-(4-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-((TETRAHYDROFURAN-2-YL)METHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204585	-	PUBCHEM	11677453	C29H32N4O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	YSWLNXFQMMFDFG-DEOSSOPVSA-N
29661	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9602	[4-[5-Phenyl-4-(2-piperazin-1-ylethylamino)furo[2,3-d]pyrimidin-6-yl]phenyl]-piperidin-1-ylmethanone	(4-(5-PHENYL-4-(2-(PIPERAZIN-1-YL)ETHYLAMINO)FURO[2,3-D]PYRIMIDIN-6-YL)PHENYL)(PIPERIDIN-1-YL)METHANONE|[4-[5-PHENYL-4-(2-PIPERAZIN-1-YLETHYLAMINO)FURO[2,3-D]PYRIMIDIN-6-YL]PHENYL]-PIPERIDIN-1-YLMETHANONE|BDBM50204584	-	PUBCHEM	11634876	C30H34N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	SXBGVYYYZFBEKG-UHFFFAOYSA-N
29662	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9603	(4-Ethylpiperazin-1-yl)-[4-[4-[[(2S)-oxolan-2-yl]methylamino]-5-phenylfuro[2,3-d]pyrimidin-6-yl]phenyl]methanone	(4-ETHYLPIPERAZIN-1-YL)-[4-[4-[[(2S)-OXOLAN-2-YL]METHYLAMINO]-5-PHENYLFURO[2,3-D]PYRIMIDIN-6-YL]PHENYL]METHANONE|(S)-(4-ETHYLPIPERAZIN-1-YL)(4-(5-PHENYL-4-((TETRAHYDROFURAN-2-YL)METHYLAMINO)FURO[2,3-D]PYRIMIDIN-6-YL)PHENYL)METHANONE|BDBM50204583	-	PUBCHEM	11656437	C30H33N5O3	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	FACSDOITOHWERB-DEOSSOPVSA-N
29663	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9604	5-Phenyl-N-(2-piperazin-1-ylethyl)-6-[4-(2-pyrrolidin-1-ylethoxy)phenyl]furo[2,3-d]pyrimidin-4-amine	5-PHENYL-N-(2-(PIPERAZIN-1-YL)ETHYL)-6-(4-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|5-PHENYL-N-(2-PIPERAZIN-1-YLETHYL)-6-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204582	-	PUBCHEM	11684933	C30H36N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	DMZTWOCJNVKCBW-UHFFFAOYSA-N
29664	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9605	5-Phenyl-N-(2-phenylethyl)-6-[4-(2-pyrrolidin-1-ylethoxy)phenyl]furo[2,3-d]pyrimidin-4-amine	Q27076548|COMPOUND 30 [PMID: 17280833]|GTPL8193|5-PHENYL-N-(2-PHENYLETHYL)-6-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-4-AMINE|5-PHENYL-N-(2-PHENYLETHYL)-6-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]FURO[3,2-E]PYRIMIDIN-4-AMINE|N-PHENETHYL-5-PHENYL-6-(4-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204580	-	PUBCHEM	11540659	C32H32N4O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	CYXPHNZJEDAZDD-UHFFFAOYSA-N
29665	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9606	N-Isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)furo[2,3-d]pyrimidin-4-amine	N-ISOPROPYL-5-PHENYL-6-(4-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|5-PHENYL-N-PROPAN-2-YL-6-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204579	-	PUBCHEM	11626406	C27H30N4O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	SSVDSZIWJBBCNN-UHFFFAOYSA-N
29666	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9607	6-(4-(Morpholinomethyl)phenyl)-5-phenyl-N-(2-(piperazin-1-yl)ethyl)furo[2,3-d]pyrimidin-4-amine	6-(4-(MORPHOLINOMETHYL)PHENYL)-5-PHENYL-N-(2-(PIPERAZIN-1-YL)ETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|6-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]-5-PHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204577	-	PUBCHEM	11620266	C29H34N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	YKMSWECJITXGJA-UHFFFAOYSA-N
29667	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9608	6-(4-Morpholinophenyl)-5-phenyl-N-(2-(piperazin-1-yl)ethyl)furo[2,3-d]pyrimidin-4-amine	6-(4-MORPHOLIN-4-YLPHENYL)-5-PHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|6-(4-MORPHOLINOPHENYL)-5-PHENYL-N-(2-(PIPERAZIN-1-YL)ETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204576	-	PUBCHEM	11648745	C28H32N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	YHTSUIXFAAQWLU-UHFFFAOYSA-N
29668	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	DiMauro EF (2007)	17280833	224894	9609	6-(4-Methyl-2,3-dihydro-1,4-benzoxazin-7-yl)-5-phenyl-N-(2-piperazin-1-ylethyl)furo[2,3-d]pyrimidin-4-amine	6-(4-METHYL-2,3-DIHYDRO-1,4-BENZOXAZIN-7-YL)-5-PHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|6-(4-METHYL-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-7-YL)-5-PHENYL-N-(2-(PIPERAZIN-1-YL)ETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE|BDBM50204575	-	PUBCHEM	11626947	C27H30N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	SWTRMCZKDHCOOZ-UHFFFAOYSA-N
29669	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Martin MW (2007)	17276681	224895	9610	3-Phenyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-N-(2-pyridin-3-ylethyl)furo[2,3-b]pyridin-4-amine	3-PHENYL-2-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-N-(2-PYRIDIN-3-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE|3-PHENYL-2-{4-[2-(PIPERIDIN-1-YL)ETHOXY]PHENYL}-N-[2-(PYRIDIN-3-YL)ETHYL]FURO[2,3-B]PYRIDIN-4-AMINE|2,3-DIARYLFURO[2,3-B]PYRIDINE-4-AMINE, 19|BDBM17723	-	PUBCHEM	11519208	C33H34N4O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	QKKHXTGUTLRIAS-UHFFFAOYSA-N
29670	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Martin MW (2007)	17276681	224895	9611	2-[4-(2-Imidazol-1-ylethoxy)phenyl]-3-phenyl-N-(2-piperazin-1-ylethyl)furo[2,3-b]pyridin-4-amine	2-{4-[2-(1H-IMIDAZOL-1-YL)ETHOXY]PHENYL}-3-PHENYL-N-[2-(PIPERAZIN-1-YL)ETHYL]FURO[2,3-B]PYRIDIN-4-AMINE|2,3-DIARYLFURO[2,3-B]PYRIDINE-4-AMINE, 15|2-[4-(2-IMIDAZOL-1-YLETHOXY)PHENYL]-3-PHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE|BDBM17719	-	PUBCHEM	11613133	C30H32N6O2	small molecule	-	-	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	WYNDNQIGGGWABE-UHFFFAOYSA-N
29772	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	unknown	target	Fabian MA (2005)	15711537	224911	1934	Staurosporine	2GCD|BCPP000063|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-METHYLAMINO-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-09|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- (9CI)|ANTIBIOTIC AM-2282|EX-A1777|9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)-BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S-(9ALPHA,10BETA,11BETA,13ALPHA)-|HMS3650B17|NCGC00162400-06|H88EPA0A3N|8-METHOXY-9-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-16-OL|BRD-K17953061-001-02-8|62996-74-1|BRD-K17953061-001-11-9|109189-95-9|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8,10,12,14(28),15(19),20(27),21,23,25-NONAEN-16-ONE|1U59|CCG-208052|STAUROSPORINE & TUMOR NECROSIS FACTOR (TNF)|NCGC00162400-02|2DQ7|MEGXM0_000307|1NVR|STAUROSPORINE;9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)-|BRD-K17953061-001-05-1|NCGC00162400-03|7158-EP2289893A1|8,12-EPOXY-1H,8H-2,7B,12A-TRIAZADIBENZO(A,G)CYCLONONA(CDE)TRINDEN-1-ONE, 2,3,9,10,11,12-HEXAHYDRO-9-METHOXY-8-METHYL-10-(METHYLAMINO)-, (8ALPHA,9BETA,10BETA,12ALPHA)-(+)-|CGP 39360|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8(13),9,11,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|AM-2282|ANTIBIOTIC AM 2282|1XJD|STAUROSPORIN|STAUROSPORINE & TNF|7158-EP2311842A2|STAUROSPORIN, 4|DB02010|METHOXY-METHYL-(METHYLAMINO)[?]ONE|NCGC00162400-01|GNF-PF-1389|7158-EP2292617A1|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, [9S-(9ALPHA,10BETA,11BETA,13ALPHA)]-|ANTIBIOTIC 230|7158-EP2308855A1|ALKALOID AM-2282 FROM STREPTOMYCES|ST50826371|1STC|HY-15141|MOLMAP_000047|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-04|(+)-STAUROSPORINE|GTPL346|7158-EP2311809A1|Q5957181|CS-2716|STAUROSPORINE, 8|AKOS015897119|BIO1_000753|BRD-K17953061-001-04-4|SR-00000001485-4|STAUROSPORINE|7158-EP2308883A1|BRD-K17953061-001-10-1|NCGC00162400-05|[9S-(9?,10?,11?,13?)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE|LS-64042|CBIOL_001978|1SM2|1Q3D|BIO1_000264|1YHS|ZINC3814434|S1421|SR-00000001485|UNII-H88EPA0A3N|7158-EP2270008A1|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- & TUMOR NECROSIS FACTOR (TNF)|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO [12.12.2.1<2,6>.0<7,28>.0<8,13>.0<15,19>.0<20,27>.0<21,26>]NONACOSA-8(13),9,11 ,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|QTL1_000078|HMS1990J07|BIO1_001242|1XBC|DTXSID30911019|CCRIS 3272|BSPBIO_001146|BRD-K17953061-001-08-5|BDBM2579	-	DRUGBANK	DB02010	C28H26N4O3	small molecule	-	62996-74-1	BINDINGDB	-	-	-	-	-	-	-	-	-	-	-	HKSZLNNOFSGOKW-UCBFMKAXSA-N
29834	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Cao K (2020)	32211658	226774	9929	Cisplatin	transplatin|cis-platin|cis-Diamminedichlorplatine|Dichloroplatinum diammoniate|cis-Diamineplatinum(II) dichloride|MFCD00011623|TP2450000|UNII:Q20Q21Q62J|TP2455000|Cisplatin impurity A	-	CHEMSPIDER	76401	H6Cl2N2Pt	small molecule	-	14913-33-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	LXZZYRPGZAFOLE-UHFFFAOYSA-L
29836	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Ishizawa J (2018)	29490944	228642	9913	DS-3032B	-	-	CHEMSPIDER	71060369	C37H44Cl2FN5O8S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	WPJOGWGXMTUHPW-CIPNXXNHSA-N
29837	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Holzer P (2015)	26181851	224770	9193	Nvp-cgm097	ZINC253387855|(1S)-1-(4-CHLOROPHENYL)-6-METHOXY-2-[4-[METHYL-[[4-(4-METHYL-3-OXOPIPERAZIN-1-YL)CYCLOHEXYL]METHYL]AMINO]PHENYL]-7-PROPAN-2-YLOXY-1,4-DIHYDROISOQUINOLIN-3-ONE|(S)-1-(4-CHLOROPHENYL)-7-ISOPROPOXY-6-METHOXY-2-(4-[METHYL[4-(4-METHYL-3-OXOPIPERAZIN-1-YL)-TRANS-CYCLOHEXYLMETHYL]AMINO]PHENYL)-1,4-DIHYDRO-2H-ISOQUINOLIN-3-ONE|4UF6MSL0ZH|NVP-CGM-097|KS-00000TSY|CCG-270337|US9051279, 106|(1S)-1-(4-CHLOROPHENYL)-6-METHOXY-2-[4-(METHYL{[TRANS-4-(4-METHYL-3-OXOPIPERAZIN-1-YL)CYCLOHEXYL]METHYL}AMINO)PHENYL]-7-(PROPAN-2-YLOXY)-1,4-DIHYDROISOQUINOLIN-3(2H)-ONE|EX-A1059|CS-3138|HY-15954|NVP-CGM097 (CGM-097)|NVP-CGM097|Q27454942|NCGC00390552-01|W5747|4T4|NVP CGM097|(1S)-1-(4-CHLOROPHENYL)-6-METHOXY-2-{4-[METHYL({[(1R,4R)-4-(4-METHYL-3-OXOPIPERAZIN-1-YL)CYCLOHEXYL]METHYL})AMINO]PHENYL}-7-(PROPAN-2-YLOXY)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-ONE|C38H47CLN4O4|1313363-54-0|(1S)-1-(4-CHLOROPHENYL)-1,4-DIHYDRO-6-METHOXY-7-(1-METHYLETHOXY)-2-[4-[METHYL[[TRANS-4-(4-METHYL-3-OXO-1-PIPERAZINYL)CYCLOHEXYL]METHYL]AMINO]PHENYL]-3(2H)-ISOQUINOLINONE|CGM-097|(S)-1-(4-CHLOROPHENYL)-7-ISOPROPOXY-6-METHOXY-2-(4-(METHYL(((1R,4S)-4-(4-METHYL-3-OXOPIPERAZIN-1-YL)CYCLOHEXYL)METHYL)AMINO)PHENYL)-1,2-DIHYDROISOQUINOLIN-3(4H)-ONE|UNII-4UF6MSL0ZH|A16326|AS-75288|S7875|CGM097|J3.509.326E|CGM 097|BCP18308|AKOS030526402|BDBM162123	-	PUBCHEM	53240420	C38H47ClN4O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	CLRSLRWKONPSRQ-CPOWQTMSSA-N
29838	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Furet P (2016)	27542305	228643	9857	Siremadlin	-	-	CHEMSPIDER	27542305	C11H6F3N3O	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	NJLJARSIRPKVMU-UHFFFAOYSA-N
29839	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Sun D (2014)	24456472	224788	9232	Mdm2 inhibitor amg-232	AC-29027|1352066-68-2|ZINC103248035|COMPOUND 2 [PMID: 24456472]|SB17210|AMG 232|GTPL11133|C28H35CL2NO5S|HY-12296|2-((3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-1-((S)-1-(ISOPROPYLSULFONYL)-3-METHYLBUTAN-2-YL)-3-METHYL-2-OXOPIPERIDIN-3-YL)ACETIC ACID|KRT232|V2654|MDM2 INHIBITOR AMG-232|2-[(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-3-METHYL-1-[(2S)-3-METHYL-1-PROPAN-2-YLSULFONYLBUTAN-2-YL]-2-OXOPIPERIDIN-3-YL]ACETIC ACID|AMG232|AOB87308|3-IPERIDINEACETIC ACID, 5-(3-HLOROPHENYL)-6-(4-HLOROPHENYL)-3-ETHYL-1-(1S)-2-ETHYL-1-[(1-ETHYLETHYL)ULFONYL]ETHYL]ROPYL]-2-XO-, (3R,5R,6S)-|AMG-232|UNII-7R7G6EH5UL|CS-3282|DB15299|(3R,5R,6S)-5-(3-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-3-METHYL-1-((1S)-2-METHYL-1-(((1-METHYLETHYL)SULFONYL)METHYL)PROPYL)-2-OXO-3-PIPERIDINEACETIC ACID|NCGC00387801-04|AS-17007|NCGC00387801-05|KRT-232|1447813-21-9|7R7G6EH5UL|BDBM50448947	-	PUBCHEM	58573469	C28H35Cl2NO5S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	DRLCSJFKKILATL-YWCVFVGNSA-N
29840	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Yi H (2018)	29716622	228645	9893	APG-115	-	-	CHEMSPIDER	64853887	C34H38Cl2FN3O4	small molecule	-	1818393-16-6	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	YJCZPJQGFSSFOL-MNZPCBJKSA-N
29936	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Vu B (2013)	24900694	228678	8379	RG7112	RO-5045337|Q8MI0X869M|{(4S,5R)-4,5-Bis(4-chlorophenyl)-2-[2-ethoxy-4-(2-methyl-2-propanyl)phenyl]-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl}{4-[3-(methylsulfonyl)propyl]-1-piperazinyl}methanone|Methanone, [(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]-	-	CHEMSPIDER	28189760	C38H48Cl2N4O4S	small molecule	-	939981-39-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	QBGKPEROWUKSBK-QPPIDDCLSA-N
29940	110359	4194	RP11-430C7.1	MDM4	HDMX|MDMX|MRP1	9606	Homo sapiens	inhibitor	target	Reed D (2010)	20080970	228679	9926	SJ 172550	SJ 172550|MFCD03142926|SJ-172550|2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid methyl ester|Methyl {2-chloro-6-ethoxy-4-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl]phenoxy}acetate|Acetic acid, 2-[2-chloro-4-[(Z)-(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-, methyl ester	-	CHEMSPIDER	1104430	C22H21ClN2O5	small molecule	-	431979-47-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	RKKFQJXGAQWHBZ-YVLHZVERSA-N
29941	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Gu L (2016)	27666947	228680	9898	MX69	Benzoic acid, 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-|4-{8-[(3,4-Dimethylphenyl)sulfamoyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl}benzoic acid	-	CHEMSPIDER	3290554	C27H26N2O4S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	XCBONKHCCRJMNW-UHFFFAOYSA-N
29943	119920	54165	-	DCUN1D1	DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3	9606	Homo sapiens	inhibitor	target	Wang S (2019)	30803229	219782	9901	WS-383	1H-Tetrazole-1-ethanamine, 5-[[2-[[(4-chlorophenyl)methyl]thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-, hydrochloride (1:1)|2-[5-({2-[(4-Chlorobenzyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)-1H-tetrazol-1-yl]-N,N-dimethylethanamine hydrochloride (1:1)	-	CHEMSPIDER	72380023	C18H21Cl2N9S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	LJZUAAKUJAXXHQ-UHFFFAOYSA-N
29944	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Zhang Z (2014)	24997575	228681	9839	RO8994	RO8994|Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-, (2'S,3R,4'S,5'R)-|(2'S,3R,4'S,5'R)-N-(4-Carbamoyl-2-methoxyphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide	-	CHEMSPIDER	31135025	C31H31Cl2FN4O4	small molecule	-	1309684-94-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	MURAVORBGFDSMA-ISKXDESKSA-N
29945	110359	4194	RP11-430C7.1	MDM4	HDMX|MDMX|MRP1	9606	Homo sapiens	inhibitor	target	Karan G (2016)	26883273	228682	9865	Ctx1	9-Acridinecarbonitrile, 3,6-diamino-|3,6-Diamino-9-acridinecarbonitrile	-	CHEMSPIDER	384728	C14H10N4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	PUMGFEMNXBLDKD-UHFFFAOYSA-N
29946	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Huang Y (2014)	24405416	228683	9841	YH239-EE	1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester|Ethyl 6-chloro-3-{1-[(4-chlorobenzyl)(formyl)amino]-2-[(2-methyl-2-propanyl)amino]-2-oxoethyl}-1H-indole-2-carboxylate|YH239-EE|YH 239-EE	-	CHEMSPIDER	31042602	C25H27Cl2N3O4	small molecule	-	1364488-67-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	OTUBDDRFPQLPKD-UHFFFAOYSA-N
29947	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Porter JR (2010)	20856941	228684	9838	BH3I-1	BH3I-1|MFCD03453544|5-(p-Bromobenzylidine)-alpha-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid|3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-alpha-(1-methylethyl)-4-oxo-2-thioxo-, (5E)-|2-[(5E)-5-(4-Bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-methylbutanoic acid	-	CHEMSPIDER	23291035	C15H14BrNO3S2	small molecule	-	300817-68-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	COHIEJLWRGREHV-YRNVUSSQSA-N
29948	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Chen R (2017)	28581721	228685	9751	Bivalent ligand 197	CG428|Bivalent_ligand_197	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	-	-	-	-	-	-	-	-	-	-
29949	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Gollner A (2016)	27775892	228686	9872	BI-0252	Benzoic acid, 4-[(3S,3'S,3a'S,5'R,6a'S)-6-chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylmethyl)-1,2,3',3'a,4',5',6',6'a-octahydro-2-oxospiro[3H-indole-3,2'(1'H)-pyrrolo[3,2-b]pyrrol]-5'-yl]-|4-[(3S,3'S,3a'S,5'R,6a'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-1'-(cyclopropylmethyl)-2-oxo-1,2,3',3a',4',5',6',6a'-octahydro-1'H-spiro[indole-3,2'-pyrrolo[3,2-b]pyrrol]-5'-yl]benzoic acid	-	CHEMSPIDER	59053072	C30H26Cl2FN3O3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	CCPUFNJKOGKOOG-AFKAWQRRSA-N
29950	119920	54165	-	DCUN1D1	DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3	9606	Homo sapiens	inhibitor	target	Wang S (2019)	30803229	219782	9869	2-[5-({2-[(4-Chlorobenzyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)-1H-tetrazol-1-yl]-N,N-dimethylethanamine	2-[5-({2-[(4-Chlorobenzyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)-1H-tetrazol-1-yl]-N,N-dimethylethanamine|1H-Tetrazole-1-ethanamine, 5-[[2-[[(4-chlorophenyl)methyl]thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-	-	CHEMSPIDER	84398507	C18H20ClN9S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	MGESDQAAIJOGJA-UHFFFAOYSA-N
29951	119920	54165	-	DCUN1D1	DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3	9606	Homo sapiens	inhibitor	target	Zhou H (2017)	29074978	206893	9870	DI-591	N-[(1S)-1-Cyclohexyl-2-{[3-(4-morpholinyl)propanoyl]amino}ethyl]-3-(6-isopropyl-1,3-benzothiazol-2-yl)-N~2~-propionyl-L-alaninamide|2-Benzothiazolepropanamide, N-[(1S)-1-cyclohexyl-2-[[3-(4-morpholinyl)-1-oxopropyl]amino]ethyl]-6-(1-methylethyl)-alpha-[(1-oxopropyl)amino]-, (alphaS)-	-	CHEMSPIDER	88297468	C31H47N5O4S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	CNJKDQGPBAWNRY-IZZNHLLZSA-N
29953	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Wang W (2018)	30217928	228687	9860	MA242	Acetic acid, 2,2,2-trifluoro-, compd. with 7-[[(4-chlorophenyl)methyl]amino]-3,4-dihydro-1-[(4-methylphenyl)sulfonyl]pyrrolo[4,3,2-de]quinolin-8(1H)-one (1:1)|7-[(4-Chlorobenzyl)amino]-1-[(4-methylphenyl)sulfonyl]-3,4-dihydropyrrolo[4,3,2-de]quinolin-8(1H)-one trifluoroacetate (1:1)	-	CHEMSPIDER	75533946	C26H21ClF3N3O5S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	YTSFRIUMZUCDMV-UHFFFAOYSA-N
29954	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Graves B (2012)	22745160	216713	9905	RO-5963	2-{(4E)-4-[(6-Chloro-7-methyl-1H-indol-3-yl)methylene]-2,5-dioxo-1-imidazolidinyl}-2-(3,4-difluorophenyl)-N-(1,3-dihydroxy-2-propanyl)acetamide|1-Imidazolidineacetamide, 4-[(6-chloro-7-methyl-1H-indol-3-yl)methylene]-alpha-(3,4-difluorophenyl)-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-2,5-dioxo-, (4E)-	-	CHEMSPIDER	75533987	C24H21ClF2N4O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	ZFYQBPVMECJUBO-FBCYGCLPSA-N
29955	110359	4194	RP11-430C7.1	MDM4	HDMX|MDMX|MRP1	9606	Homo sapiens	inhibitor	target	Graves B (2012)	22745160	216713	9905	RO-5963	2-{(4E)-4-[(6-Chloro-7-methyl-1H-indol-3-yl)methylene]-2,5-dioxo-1-imidazolidinyl}-2-(3,4-difluorophenyl)-N-(1,3-dihydroxy-2-propanyl)acetamide|1-Imidazolidineacetamide, 4-[(6-chloro-7-methyl-1H-indol-3-yl)methylene]-alpha-(3,4-difluorophenyl)-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-2,5-dioxo-, (4E)-	-	CHEMSPIDER	75533987	C24H21ClF2N4O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	ZFYQBPVMECJUBO-FBCYGCLPSA-N
29956	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Chen R (2017)	28581721	228685	9921	2-[4-({(4S,5R)-4,5-Bis(4-chlorophenyl)-2-[2-ethoxy-4-(2-methyl-2-propanyl)phenyl]-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl}carbonyl)-1-piperazinyl]-1-(4-morpholinyl)ethanone dihydrochloride	2-[4-({(4S,5R)-4,5-Bis(4-chlorophenyl)-2-[2-ethoxy-4-(2-methyl-2-propanyl)phenyl]-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl}carbonyl)-1-piperazinyl]-1-(4-morpholinyl)ethanone dihydrochloride|Ethanone, 2-[4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl]carbonyl]-1-piperazinyl]-1-(4-morpholinyl)-, hydrochloride (1:2)	-	CHEMSPIDER	35308372	C40H51Cl4N5O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	LSDSITOZGWIHGA-IBBBAUQKSA-N
29994	119920	54165	-	DCUN1D1	DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3	9606	Homo sapiens	inhibitor	target	Scott DC (2017)	28581483	211304	9853	NAcM-HIT	Urea, N-[1-(phenylmethyl)-4-piperidinyl]-N'-[3-(trifluoromethyl)phenyl]-|1-(1-Benzyl-4-piperidinyl)-3-[3-(trifluoromethyl)phenyl]urea	-	CHEMSPIDER	3073302	C20H22F3N3O	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	MXZRHPHRSQJCML-UHFFFAOYSA-N
29995	119920	54165	-	DCUN1D1	DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3	9606	Homo sapiens	inhibitor	target	Scott DC (2017)	28581483	211304	9933	NAcM-OPT	Urea, N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-|1-Benzyl-1-(1-butyl-4-piperidinyl)-3-(3,4-dichlorophenyl)urea	-	CHEMSPIDER	59052433	C23H29Cl2N3O	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	VPHJABWIKCBGMC-UHFFFAOYSA-N
29996	119920	54165	-	DCUN1D1	DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3	9606	Homo sapiens	inhibitor	target	Kim HS (2019)	31465221	228079	9890	3-Methyl-N-[(4S,5R)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide	Benzamide, 3-methyl-N-[(4S,5R)-4,5,6,7-tetrahydro-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-|3-Methyl-N-[(4S,5R)-3-methyl-4-(4-methylphenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]benzamide	-	CHEMSPIDER	78310128	C28H26N4O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	This small molecule corresponds to Compound 1 in this paper.	WMAFBTHYXHDENE-LOSJGSFVSA-N
29997	119920	54165	-	DCUN1D1	DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3	9606	Homo sapiens	inhibitor	target	Kim HS (2019)	31465221	228079	9935	N-[1-[4-(Aminomethyl)-3-methylsulfonylphenyl]but-3-en-2-yl]-5-[[(2S)-2-azido-3-phenylpropanoyl]amino]-2-(2-methylpropyl)-4-oxooctanamide	N-[1-[4-(Aminomethyl)-3-methylsulfonylphenyl]but-3-en-2-yl]-5-[[(2S)-2-azido-3-phenylpropanoyl]amino]-2-(2-methylpropyl)-4-oxooctanamide|N3Phe-Leu-Leu-Phe(4-CH2NH2)VS|azido-phenylalanyl-leucyl-leucyl-4-aminomethylphenylalanyl methyl vinyl sulfone|azido-Phe-Leu-Leu-4-aminomethyl-Phe-methyl vinyl sulfone|N-[(4S,5S)-1-[(1S)-Cyclohex-3-en-1-yl]-7-ethyl-4-(4-fluorophenyl)-3-methyl-6-oxo-4,5-dihydropyrazolo[3,4-b]pyridin-5-yl]-3-methylbenzamide	-	PUBCHEM	145946100	C29H31FN4O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	This small molecule corresponds to Compound 27 in this paper.	DRGYLPYZJGVISN-AFESJLNVSA-N
30043	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Chen H (2019)	30901674	215477	9796	Bivalent ligand 184	Compound 2|Bivalent_ligand_184	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: Compound 2 (CRBN:pomalidomide --- BRAF: rigosertib)	-
30049	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Wu H (2019)	31271281	228479	9797	Bivalent ligand 185	PROTAC 12d|Bivalent_ligand_185	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 12d (CRBN:pomalidomide --- IKZF1:Nexturastat A (Nex A))	-
30299	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	target	Li Y (2019)	30525597	223612	9809	Bivalent ligand 246	MD-222|Bivalent_ligand_246	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MD-222 (CRBN:lenalidomide --- MDM2:MI-1061)	-
30321	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Alabi S (2021)	33568647	228724	9815	Bivalent ligand 253	SJF-0628|Bivalent_ligand_253	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SJF-0628 (VHL:HIF-1alpha hydroxyproline derived small molecule --- BRAF V600E mutant:vemurafenib)	-
30361	132934	389015	-	SLC9A4	NHE4	9606	Homo sapiens	degradation	target	Bensimon A (2020)	32386596	223637	8522	Bivalent ligand 132	d9A-2|Bivalent_ligand_132	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: d9A2 (CRBN:phthalimide --- SLC9A4:W9A)	-
30372	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	inhibitor	target	Pairawan S (2021)	33663585	228644	9937	ALRN-6924	CS-0044703	-	PUBCHEM	381833444	-	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	-
30373	110359	4194	RP11-430C7.1	MDM4	HDMX|MDMX|MRP1	9606	Homo sapiens	inhibitor	target	Pairawan S (2021)	33663585	228644	9937	ALRN-6924	CS-0044703	-	PUBCHEM	381833444	-	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	-	-
30576	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- CDK4:TAE684)	-
30580	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- CDK6:TAE684)	-
30690	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- TNK2:TAE684)	-
30742	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide--- CDK4:TAE684)	-
30746	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide--- CDK6:TAE684)	-
30826	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide--- TNK2:TAE684)	-
30848	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10011	Bivalent Ligand 267	DB0646|Bivalent_Ligand_267	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0646 (CRBN:Thalidomide--- CDK4:GNF-7)	-
30854	108356	2042	-	EPHA3	EK4|ETK|ETK1|HEK|HEK4|TYRO4	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10011	Bivalent Ligand 267	DB0646|Bivalent_Ligand_267	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0646 (CRBN:Thalidomide--- EPHA3:GNF-7)	-
30856	108363	2049	-	EPHB3	ETK2|HEK2|TYRO6	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10011	Bivalent Ligand 267	DB0646|Bivalent_Ligand_267	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0646 (CRBN:Thalidomide--- EPHB3:GNF-7)	-
30898	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10011	Bivalent Ligand 267	DB0646|Bivalent_Ligand_267	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0646 (CRBN:Thalidomide--- MAPK9:GNF-7)	-
30926	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10011	Bivalent Ligand 267	DB0646|Bivalent_Ligand_267	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0646 (CRBN:Thalidomide--- TNK2:GNF-7)	-
30958	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10006	Bivalent Ligand 268	FMF-06-098-1|Bivalent_Ligand_268	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: FMF-06-098-1 (VHL:VHL-1--- CDK4:TAE)	-
30960	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10006	Bivalent Ligand 268	FMF-06-098-1|Bivalent_Ligand_268	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: FMF-06-098-1 (VHL:VHL-1--- CDk6:TAE)	-
30974	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10006	Bivalent Ligand 268	FMF-06-098-1|Bivalent_Ligand_268	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: FMF-06-098-1 (VHL:VHL-1--- FGFR1:TAE)	-
31012	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10006	Bivalent Ligand 268	FMF-06-098-1|Bivalent_Ligand_268	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: FMF-06-098-1 (VHL:VHL-1--- TNK2:TAE)	-
31056	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10005	Bivalent Ligand 269	TMX-02-174|Bivalent_Ligand_269	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-174 (CRBN:pomalidomide--- MAPK9:Ceritinib)	-
31106	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10035	Bivalent Ligand 270	DB0662|Bivalent_Ligand_270	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0662 (CRBN:thalidomide--- CDK4:GNF-7)	-
31134	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10035	Bivalent Ligand 270	DB0662|Bivalent_Ligand_270	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0662 (CRBN:thalidomide--- MAPK9:GNF-7)	-
31154	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10035	Bivalent Ligand 270	DB0662|Bivalent_Ligand_270	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0662 (CRBN:thalidomide--- TNK2:GNF-7)	-
31180	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10036	Bivalent Ligand 271	TL13-97|Bivalent_Ligand_271	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-97 (CRBN:pomalidomide--- CDK4:Rebastinib)	-
31184	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10036	Bivalent Ligand 271	TL13-97|Bivalent_Ligand_271	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-97 (CRBN:pomalidomide--- CDK6:Rebastinib)	-
31218	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10036	Bivalent Ligand 271	TL13-97|Bivalent_Ligand_271	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-97 (CRBN:pomalidomide--- TNK2:Rebastinib)	-
31238	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10033	Bivalent Ligand 272	SB1-G-187|Bivalent_Ligand_272	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SB1-G-187 (CRBN:Thalidomide--- CDK6:Ponatinib)	-
31296	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10034	Bivalent Ligand 273	DB1114|Bivalent_Ligand_273	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1114 (VHL:VHL-1--- CDK4:GNF-7)	-
31302	108356	2042	-	EPHA3	EK4|ETK|ETK1|HEK|HEK4|TYRO4	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10034	Bivalent Ligand 273	DB1114|Bivalent_Ligand_273	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1114 (VHL:VHL-1--- EPHA3:GNF-7)	-
31326	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10034	Bivalent Ligand 273	DB1114|Bivalent_Ligand_273	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1114 (VHL:VHL-1--- MAPK9:GNF-7)	-
31346	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10034	Bivalent Ligand 273	DB1114|Bivalent_Ligand_273	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1114 (VHL:VHL-1--- TNK2:GNF-7)	-
31358	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10039	Bivalent Ligand 274	DB1113|Bivalent_Ligand_274	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1113 (VHL:VHL-1--- CDK4:GNF-7)	-
31362	108356	2042	-	EPHA3	EK4|ETK|ETK1|HEK|HEK4|TYRO4	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10039	Bivalent Ligand 274	DB1113|Bivalent_Ligand_274	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1113 (VHL:VHL-1--- EPHA3:GNF-7)	-
31386	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10039	Bivalent Ligand 274	DB1113|Bivalent_Ligand_274	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1113 (VHL:VHL-1--- MAPK9:GNF-7)	-
31410	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10039	Bivalent Ligand 274	DB1113|Bivalent_Ligand_274	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1113 (VHL:VHL-1--- TNK2:GNF-7)	-
31450	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10040	Bivalent Ligand 275	TMX-02-138|Bivalent_Ligand_275	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-138 (CRBN:pomalidomide--- MAPK9:Ceritinib)	-
31482	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10037	Bivalent Ligand 276	MFH-5-126-1|Bivalent_Ligand_276	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MFH-5-126-1 (CRBN:pomalidomide--- CDK4:AT7519)	-
31532	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10038	Bivalent Ligand 277	RSS0680|Bivalent_Ligand_277	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: RSS0680 (VHL:VHL-1--- CDK4:Thienopyrimidines)	-
31534	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10038	Bivalent Ligand 277	RSS0680|Bivalent_Ligand_277	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: RSS0680 (VHL:VHL-1--- CDK6:Thienopyrimidines)	-
31588	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10041	Bivalent Ligand 278	SK-3-93|Bivalent_Ligand_278	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-93 (CRBN:Thalidomide--- CDK4:TAE684)	-
31592	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10041	Bivalent Ligand 278	SK-3-93|Bivalent_Ligand_278	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-93 (CRBN:Thalidomide--- CDK6:TAE684)	-
31628	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10042	Bivalent Ligand 279	DB0614|Bivalent_Ligand_279	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0614 (CRBN:Thalidomide--- CDK4:Thienopyrimidines)	-
31630	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10042	Bivalent Ligand 279	DB0614|Bivalent_Ligand_279	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0614 (CRBN:Thalidomide--- CDK6:Thienopyrimidines)	-
31646	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10042	Bivalent Ligand 279	DB0614|Bivalent_Ligand_279	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0614 (CRBN:Thalidomide--- MAPK9:Thienopyrimidines)	-
31672	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10067	Bivalent Ligand 283	LT2-49|Bivalent_Ligand_283	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: LT2-49 (CRBN:Thalidomide---CDK4:TAE684)	-
31682	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10067	Bivalent Ligand 283	LT2-49|Bivalent_Ligand_283	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: LT2-49 (CRBN:Thalidomide--- CDK6:TAE684)	-
31728	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10066	Bivalent Ligand 284	DD-03-106|Bivalent_Ligand_284	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DD-03-106 (CRBN:pomalidomide--- CDK4:Dabrafenib)	-
31730	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10066	Bivalent Ligand 284	DD-03-106|Bivalent_Ligand_284	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DD-03-106 (CRBN:pomalidomide--- CDK6:Dabrafenib)	-
31766	108356	2042	-	EPHA3	EK4|ETK|ETK1|HEK|HEK4|TYRO4	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10065	Bivalent Ligand 285	SB1-G-192-1|Bivalent_Ligand_285	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SB1-G-192-1 (CRBN:Thalidomide--- EPHA3:PP58 (kinobeads) 212391-57-6)	-
31790	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10065	Bivalent Ligand 285	SB1-G-192-1|Bivalent_Ligand_285	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SB1-G-192-1 (CRBN:Thalidomide--- TNK2:PP58 (kinobeads) 212391-57-6)	-
31808	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10064	Bivalent Ligand 286	SK-3-89|Bivalent_Ligand_286	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-89 (CRBN:Thalidomide--- CDK4:TAE684)	-
31812	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10064	Bivalent Ligand 286	SK-3-89|Bivalent_Ligand_286	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-89 (CRBN:Thalidomide--- CDK6:TAE684)	-
31832	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10063	Bivalent Ligand 287	DB0663|Bivalent_Ligand_287	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0663 (CRBN:Thalidomide---CDK4:GNF-7)	-
31856	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10063	Bivalent Ligand 287	DB0663|Bivalent_Ligand_287	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0663 (CRBN:Thalidomide---a MAPK9:GNF-7)	-
31864	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10063	Bivalent Ligand 287	DB0663|Bivalent_Ligand_287	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0663 (CRBN:Thalidomide--- TNK2:GNF-7)	-
31868	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10062	Bivalent Ligand 288	DB0661|Bivalent_Ligand_288	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0661 (CRBN:Thalidomide--- CDK4:GNF-7)	-
31882	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10062	Bivalent Ligand 288	DB0661|Bivalent_Ligand_288	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0661 (CRBN:Thalidomide--- MAPK9:GNF-7)	-
31894	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10062	Bivalent Ligand 288	DB0661|Bivalent_Ligand_288	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0661 (CRBN:Thalidomide--- TNK2:GNF-7)	-
31944	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10089	Bivalent Ligand 290	TMX-01-160-1|Bivalent_Ligand_290	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-01-160-1 (CRBN:Thalidomide--- CDK4:Ceritinib)	-
31948	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10089	Bivalent Ligand 290	TMX-01-160-1|Bivalent_Ligand_290	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-01-160-1 (CRBN:Thalidomide--- CDK6:Ceritinib)	-
31958	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10089	Bivalent Ligand 290	TMX-01-160-1|Bivalent_Ligand_290	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-01-160-1 (CRBN:Thalidomide--- MAPK9:Ceritinib)	-
31992	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10091	Bivalent Ligand 292	MFH-5-115-2|Bivalent_Ligand_292	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MFH-5-115-2 (CRBN:pomalidomide---CDK4:Dinaciclib)	-
32084	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10086	Bivalent Ligand 295	RSS0628|Bivalent_Ligand_295	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: RSS0628 (CRBN:Thalidomide--- CDK4:Thienopyrimidines)	-
32086	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10086	Bivalent Ligand 295	RSS0628|Bivalent_Ligand_295	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: RSS0628 (CRBN:Thalidomide--- CDK6:Thienopyrimidines)	-
32142	111587	5601	-	MAPK9	JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10088	Bivalent Ligand 297	TMX-02-172|Bivalent_Ligand_297	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-172 (CRBN:pomalidomide--- MAPK9:Ceritinib)	-
32284	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10017	Bivalent Ligand 304	DB118430|Bivalent_Ligand_304	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	106828	331	RP1-315G1.5	XIAP	API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB118430 (IAP:LCL161 derivative--- CDK4:GNF-7)	-
32294	115485	10188	-	TNK2	ACK|ACK-1|ACK1|p21cdc42Hs	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10017	Bivalent Ligand 304	DB118430|Bivalent_Ligand_304	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	106828	331	RP1-315G1.5	XIAP	API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB118430 (IAP:LCL161 derivative--- TNK2:GNF-7)	-
32318	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8516	Bivalent ligand 76	protac 6|BSJ-03-123|Bivalent_ligand_76	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-03-123 (CRBN:pomalidomide--- CDK4:Palbociclib)	-
32320	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8516	Bivalent ligand 76	protac 6|BSJ-03-123|Bivalent_ligand_76	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-03-123 (CRBN:pomalidomide--- CDK6:Palbociclib)	-
32338	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10015	Bivalent Ligand 306	SB1-G-194|Bivalent_Ligand_306	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SB1-G-194 (CRBN:Thalidomide--- CDK6:kinobeads)	-
32378	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10014	Bivalent Ligand 309	BSJ-04-132|Bivalent_Ligand_309	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-04-132 (CRBN:Thalidomide--- CDK4:Ribociclib)	-
32380	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10014	Bivalent Ligand 309	BSJ-04-132|Bivalent_Ligand_309	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-04-132 (CRBN:Thalidomide--- CDK6:Ribociclib)	-
32422	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9992	Bivalent Ligand 312	INY-03-041-01|Bivalent_Ligand_312	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-03-041-01 (CRBN:lenalidomide--- CDK4:Ipatasertib)	-
32428	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9991	Bivalent Ligand 313	TL13-178|Bivalent_Ligand_313	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-178 (CRBN:pomalidomide---CDK4:Ponatininb)	-
32480	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9986	Bivalent Ligand 319	BSJ-03-204|Bivalent_Ligand_319	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-03-204 (CRBN:thalidomide---CDK4:Palbociclib)	-
32482	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9986	Bivalent Ligand 319	BSJ-03-204|Bivalent_Ligand_319	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-03-204 (CRBN:Thalidomide--- CDK6:Palbociclib)	-
32510	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10141	Bivalent Ligand 323	BSJ-01-147|Bivalent_Ligand_323	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-01-147 (CRBN:pomalidomide---CDK4:Palbociclib)	-
32512	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10141	Bivalent Ligand 323	BSJ-01-147|Bivalent_Ligand_323	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-01-147 (CRBN:pomalidomide--- CDK6:Palbociclib)	-
32550	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10116	Bivalent Ligand 331	YKL-06-102|Bivalent_Ligand_331	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: YKL-06-102 (CRBN:pomalidomide---CDK4:Palbociclib)	-
32552	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10116	Bivalent Ligand 331	YKL-06-102|Bivalent_Ligand_331	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: YKL-06-102 (CRBN:pomalidomide---CDK6:Palbociclib)	-
32560	110359	4194	RP11-430C7.1	MDM4	HDMX|MDMX|MRP1	9606	Homo sapiens	degradation	target	Yan S (2021)	34093856	232273	10110	Bivalent ligand 334	dCeMM4|Bivalent_ligand_334	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: Nano-MP@PSI (VHL:Nano-MP@PSI---MDMX:Nano-MP@PSI)	-
32562	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Qu X (2021)	33773286	232265	10113	Bivalent Ligand 335	Bivalent_Ligand_335	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SIAIS125 (CRBN:pomalidomide---EGFR(L858R+T790M mutant):SIAIS092)	-
32564	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Qu X (2021)	33773286	232265	10112	Bivalent Ligand 336	Bivalent_Ligand_336	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SIAIS126 (CRBN:pomalidomide---EGFR(L858R+T790M mutant):SIAIS092)	-
32638	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	He K (2020)	32317208	235047	10049	Bivalent Ligand 363	PROTAC 16c|Bivalent_Ligand_363	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 16c (CRBN:lenalidomide---EGFR:osimertinib)	-
32686	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Chang Y (2021)	34110416	235255	10029	Bivalent Ligand 377	compound 5|Bivalent_Ligand_377	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 5 (CRBN:pomalidomide---IKZF1:ruxolitinib)	-
32696	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Chang Y (2021)	34110416	235255	10024	Bivalent Ligand 378	compound 6|Bivalent_Ligand_378	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 6 (CRBN:pomalidomide---IKZF1:baricitinib)	-
32706	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Chang Y (2021)	34110416	235255	10023	Bivalent Ligand 379	compound 7|Bivalent_Ligand_379	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 7 (CRBN:pomalidomide---IKZF1:ruxolitinib N-propyl analog)	-
32722	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Riching KM (2021)	33190579	235709	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide --- CDK4:TL13-87)	-
32726	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Riching KM (2021)	33190579	235709	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide --- CDK6:TL13-87)	-
32781	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	He S (2021)	34221872	233411	10146	Bivalent ligand 393	PROTAC 11a-1|Bivalent_ligand_393	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	target	Standardized BVL Name: PROTAC 11a-1 (MDM2:Nutlin-3 derivative compound 2 --- MDM2:Nutlin-3 derivative compound 2)	-
32800	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Gosavi PM (2022)	35505873	237057	10125	Bivalent ligand 402	R0/ctx|Bivalent_ligand_402	-	BIOGRID	-	-	antibody	-	-	BIOGRID	AbTAC	Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS	120241	54894	-	RNF43	RNF124|URCC	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: R0/ctx (RNF43:RNF43 ab, R0 clone --- EGFR:cetuximab)	-
32802	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Gosavi PM (2022)	35505873	237057	10124	Bivalent ligand 403	R0/matu|Bivalent_ligand_403	-	BIOGRID	-	-	antibody	-	-	BIOGRID	AbTAC	Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS	120241	54894	-	RNF43	RNF124|URCC	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: R0/matu (RNF43:RNF43 ab, R0 clone --- EGFR:matuzumab)	-
32804	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Gosavi PM (2022)	35505873	237057	10127	Bivalent ligand 404	R0/neci|Bivalent_ligand_404	-	BIOGRID	-	-	antibody	-	-	BIOGRID	AbTAC	Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS	120241	54894	-	RNF43	RNF124|URCC	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: R0/neci (RNF43:RNF43 ab, R0 clone --- EGFR:necitumumab)	-
32806	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Gosavi PM (2022)	35505873	237057	10126	Bivalent ligand 405	R0/pani|Bivalent_ligand_405	-	BIOGRID	-	-	antibody	-	-	BIOGRID	AbTAC	Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS	120241	54894	-	RNF43	RNF124|URCC	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: R0/pani (RNF43:RNF43 ab, R0 clone --- EGFR:panitumumab)	-
32808	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Gosavi PM (2022)	35505873	237057	10129	Bivalent ligand 406	R3/ctx|Bivalent_ligand_406	-	BIOGRID	-	-	antibody	-	-	BIOGRID	AbTAC	Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS	120241	54894	-	RNF43	RNF124|URCC	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: R3/ctx  (RNF43:RNF43 ab, R3 clone --- EGFR:cetuximab)	-
32812	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Gosavi PM (2022)	35505873	237057	10131	Bivalent ligand 408	Z18/ctx|Bivalent_ligand_408	-	BIOGRID	-	-	antibody	-	-	BIOGRID	AbTAC	Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS	123905	84133	hCG_40978	ZNRF3	BK747E2.3|RNF203	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: Z18/ctx (ZNRF3:Z18 --- EGFR:cetuximab)	-
32848	111308	5290	-	PIK3CA	CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha	9606	Homo sapiens	degradation	target	Wang H (2022)	35344835	239591	10059	Bivalent ligand 421	HL-8|Bivalent_ligand_421	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: HL-8(VHL:VHL ligand --- PIK3CA:compound 15a)	-
32939	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Bricelj A (2021)	34795861	243021	10389	Bivalent ligand 455	SAB401|Bivalent_ligand_455	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SAB401 (CRBN:thalidomide --- CDK6:palbociclib)	-
32941	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Bricelj A (2021)	34795861	243021	10377	Bivalent ligand 456	SAB355|Bivalent_ligand_456	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SAB355 (CRBN:pomalidomide --- CDK6:palbociclib)	-
32943	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Bricelj A (2021)	34795861	243021	10382	Bivalent ligand 457	CST837|Bivalent_ligand_457	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CST837 (CRBN:thalidomide --- CDK6:palbociclib)	-
32945	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Bricelj A (2021)	34795861	243021	10360	Bivalent ligand 458	CST651/PROTAC 27|Bivalent_ligand_458	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CST651/PROTAC 27 (VHL:modified VH298 --- CDK6:palbociclib)	-
32947	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Bricelj A (2021)	34795861	243021	10389	Bivalent ligand 455	SAB401|Bivalent_ligand_455	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SAB401 (CRBN:thalidomide --- CDK4:palbociclib)	-
32957	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Steinebach C (2020)	33133483	244369	10361	Bivalent ligand 459	PROTAC 34|Bivalent_ligand_459	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 34 (VHL:modified VH298 --- CDK6:palbociclib)	-
32959	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Steinebach C (2020)	33133483	244369	10360	Bivalent ligand 458	CST651/PROTAC 27|Bivalent_ligand_458	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CST651/PROTAC 27 (VHL:modified VH298 --- CDK6:palbociclib)	-
32961	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Steinebach C (2020)	33133483	244369	10418	Bivalent ligand 460	PROTAC 11|Bivalent_ligand_460	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 11 (CRBN:pomalidomide --- CDK6:palbociclib)	-
32963	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Steinebach C (2020)	33133483	244369	10415	Bivalent ligand 461	PROTAC 35|Bivalent_ligand_461	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	106826	329	-	BIRC2	API1|HIAP2|Hiap-2|MIHB|RNF48|c-IAP1|cIAP1	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 35 (cIAP1:IAP ligand --- CDK6:palbociclib)	-
32965	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Steinebach C (2020)	33133483	244369	10415	Bivalent ligand 461	PROTAC 35|Bivalent_ligand_461	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	106826	329	-	BIRC2	API1|HIAP2|Hiap-2|MIHB|RNF48|c-IAP1|cIAP1	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 35 (cIAP1:IAP ligand --- CDK4:palbociclib)	-
32967	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Steinebach C (2020)	33133483	244369	10415	Bivalent ligand 461	PROTAC 35|Bivalent_ligand_461	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	106827	330	-	BIRC3	AIP1|API2|CIAP2|HAIP1|HIAP1|MALT2|MIHC|RNF49|c-IAP2	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 35 (cIAP2:IAP ligand --- CDK4:palbociclib)|Standardized BVL Name: PROTAC 35 (XIAP:IAP ligand --- CDK4:palbociclib)	-
32969	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Steinebach C (2020)	33133483	244369	10415	Bivalent ligand 461	PROTAC 35|Bivalent_ligand_461	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	106828	331	RP1-315G1.5	XIAP	API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 35 (cIAP2:IAP ligand --- CDK6:palbociclib)|Standardized BVL Name: PROTAC 35 (XIAP:IAP ligand --- CDK6:palbociclib)	-
32973	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Hansen JD (2020)	32130004	246242	10413	Bivalent ligand 462	CC-92480|Bivalent_ligand_462	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CC-92480 (mezigdomide) (CRBN: CC-92480 (mezigdomide) --- IKZF1: CC-92480 (mezigdomide))	-
32977	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Matyskiela ME (2018)	28425720	207534	10411	Bivalent ligand 463	CC-220|Bivalent_ligand_463	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CC-220 (iberdomide) (CRBN:CC-220 (iberdomide) --- IKZF1: CC-220 (iberdomide))	-
32981	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Hagner PR (2015)	26002965	185946	8562	Bivalent ligand 144	thalidomide|Bivalent_ligand_144	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CC-122 (Avadomide) (CRBN:CC-122 (Avadomide) --- IKZF1: CC-122 (Avadomide))	-
32991	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Zhao M (2021)	33676183	232098	10081	Bivalent ligand 388	CC-885|Bivalent_ligand_388	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CC-885 (CRBN:CC-885 --- CDK4:CC-885)	-
33001	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Fuchs O (2023)	35933246	246246	10376	Bivalent ligand 465	BTX-1188|Bivalent_ligand_465	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BTX-1188 (CRBN:BTX-1188 --- IKZF1:BTX-1188)	-
33007	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Fuchs O (2023)	35933246	246246	10423	Bivalent ligand 467	CFT7455|Bivalent_ligand_467	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CFT7455 (CRBN:CFT7455 --- IKZF1:CFT7455)	-
33011	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Fuchs O (2023)	35933246	246246	10407	Bivalent ligand 468	CC-99282|Bivalent_ligand_468	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CC-99282 (CRBN:CC-99282 --- IKZF1:CC-99282)	-
33021	113010	7157	-	TP53	BCC7|LFS1|P53|TRP53	9606	Homo sapiens	deubiquitination	target	Liu J (2022)	35786952	245265	10410	Bivalent ligand 473	p53-DUBTACs #6|Bivalent_ligand_473	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	DUBTAC	Deubiquitinase-targeting chimera; structured as DUB binding moiety--linker--target binding moiety; target deubiquitinated via recruited deubiquitinase (DUB)	120751	55611	HSPC263	OTUB1	OTB1|OTU1	9606	Homo sapiens	recruited deubiquitinase	Standardized BVL Name: p53-DUBTACs #6 (OTUB1:DUBL-X-BCN --- TP53:p53-ODN)	-
33023	113010	7157	-	TP53	BCC7|LFS1|P53|TRP53	9606	Homo sapiens	deubiquitination	target	Liu J (2022)	35786952	245265	10428	Bivalent ligand 474	p53-DUBTACs #7|Bivalent_ligand_474	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	DUBTAC	Deubiquitinase-targeting chimera; structured as DUB binding moiety--linker--target binding moiety; target deubiquitinated via recruited deubiquitinase (DUB)	120751	55611	HSPC263	OTUB1	OTB1|OTU1	9606	Homo sapiens	recruited deubiquitinase	Standardized BVL Name: p53-DUBTACs #7 (OTUB1:DUBL-X-BCN --- TP53:p53-ODN)	-
33041	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Dobrovolsky D (2019)	30545835	246250	10386	Bivalent ligand 481	DD-03-171|Bivalent_ligand_481	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DD-03-171 (CRBN:thalidomide---IKZF1:CGI1746)	-
33087	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation 	target	Zhang X (2020)	32171162	246256	10352	Bivalent ligand 503	14o|Bivalent_ligand_503	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: 14o (VHL:VHL ligand --- EGFRL858R/T790M:XTF-262)	-
33281	110465	4322	-	MMP13	CLG3|MANDP1|MMP-13	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Yamamoto M (2021)	888800000485	232833	7270	CTS-1027	4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE|193022-04-7|RS-130830|Ro-1130830	-	DRUGBANK	DB08490	C19H20ClNO6S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction:MMP13 inhibitor; exact viral inhibition mechanism undetermined but authors show disruption of the metalloproteinase pathway is involved	ROSNVSQTEGHUKU-UHFFFAOYSA-N
33353	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Bojkova D (2023)	36644320	239397	5470	OSI-930	-	-	DRUGBANK	DB05913	-	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: c-KIT inhibitor; viral inhibition mechanism undetermined; anti-delta and omicron activity determined by a Caco-2-F03 cell line platform and caspase 3/7 activity as readout method	-
33354	110015	3815	-	KIT	C-Kit|CD117|PBT|SCFR	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Bojkova D (2023)	36644320	239397	10223	Amuvatinib	N-(1,3-Benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)-1-piperazinecarbothioamide|1-Piperazinecarbothioamide, N-(1,3-benzodioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)-|Amuvatinib|SO9S6QZB4R	-	CHEMSPIDER	9457280	C23H21N5O3S	small molecule	-	850879-09-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: c-KIT inhibitor; viral inhibition mechanism undetermined; anti-delta and omicron activity determined by a Caco-2-F03 cell line platform and caspase 3/7 activity as readout method	FOFDIMHVKGYHRU-UHFFFAOYSA-N
33511	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	Thomas E (2023)	36831540	248703	10744	Bivalent ligand 514	VNPP433-3b|bivalent_ligand_514	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	106862	367	RP11-383C12.1	AR	AIS|DHTR|HUMARA|HYSP1|KD|NR3C4|SBMA|SMAX1|TFM	9606	Homo sapiens	target	Standardized BVL Name: VNPP433-3 (MDM2:VNPP433-3 --- AR/AR-V7: VNPP433-3)	-
33514	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Nowak RP (2023)	36970148	250541	10745	Bivalent ligand 515	isoindolinone (EM12)|bivalent_ligand_515	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: isoindolinone (EM12) (CRBN: isoindolinone (EM12) --- IKZF1:isoindolinone (EM12))	-
33516	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Nowak RP (2023)	36970148	250541	10746	Bivalent ligand 516	4-OH-EM12|bivalent_ligand_516	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: 4-OH-EM12 (CRBN:4-OH-EM12 --- IKZF1:4-OH-EM12)	-
33522	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Nowak RP (2023)	36970148	250541	8561	Bivalent ligand 143	lenalidomide|Bivalent_ligand_143	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: lenalidomide (CRBN:lenalidomide --- IKZF1:lenalidomide)	-
33524	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Nowak RP (2023)	36970148	250541	10748	Bivalent ligand 518	5-NH2-EM12|bivalent_ligand_518	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: 5-NH2-EM12 (CRBN:5-NH2-EM12 --- IKZF1:5-NH2-EM12)	-
33526	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Nowak RP (2023)	36970148	250541	10749	Bivalent ligand 519	6-NH2-EM12|bivalent_ligand_519	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: 6-NH2-EM12 (CRBN: 6-NH2-EM12 --- IKZF1: 6-NH2-EM12)	-
33530	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Nowak RP (2023)	36970148	250541	8562	Bivalent ligand 144	thalidomide|Bivalent_ligand_144	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: thalidomide (CRBN:thalidomide --- IKZF1:thalidomide)	-
33534	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Nowak RP (2023)	36970148	250541	8560	Bivalent ligand 142	pomalidomide|Bivalent_ligand_142	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: pomalidomide (CRBN:pomalidomide --- IKZF1:pomalidomide)	-
33536	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Nowak RP (2023)	36970148	250541	10750	Bivalent ligand 521	5-NH2-Thal|bivalent_ligand_521	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: 5-NH2-Thal (CRBN:5-NH2-Thal --- IKZF1:5-NH2-Thal)	-
33540	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Si R (2023)	37030566	250553	10751	Bivalent ligand 522	PROTAC-1|bivalent_ligand_522	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC-1 (VHL:VH032 --- BRAF:S5)	-
33542	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Si R (2023)	37030566	250553	10752	Bivalent ligand 523	PROTAC-2|bivalent_ligand_523	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC-2 (VHL:VH032 --- BRAF:S5)	-
33544	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Si R (2023)	37030566	250553	10753	Bivalent ligand 524	PROTAC-3|bivalent_ligand_524	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC-3 (VHL:VH032 --- BRAF:S5)	-
33546	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	degradation	target	Si R (2023)	37030566	250553	10751	Bivalent ligand 522	PROTAC-1|bivalent_ligand_522	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC-1 (VHL:VH032 --- KDR:S5)	-
33548	109992	3791	-	KDR	CD309|FLK1|VEGFR|VEGFR2	9606	Homo sapiens	degradation	target	Si R (2023)	37030566	250553	10752	Bivalent ligand 523	PROTAC-2|bivalent_ligand_523	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC-2 (VHL:VH032 --- KDR:S5)	-
33586	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	De Dominici M (2020)	32040545	256620	10765	Bivalent ligand 536	YX-2-107|bivalent_ligand_536	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: YX-2-107 (CRBN:thalidomide --- CDK6:palbociclib)	-
33587	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	De Dominici M (2020)	32040545	256620	10766	Bivalent ligand 537	YX-2-233|bivalent_ligand_537	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	target	Standardized BVL Name: YX-2-233 (MDM2:RG7112 --- CDK6:palbociclib)	-
33589	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	De Dominici M (2020)	32040545	256620	10766	Bivalent ligand 537	YX-2-233|bivalent_ligand_537	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	target	Standardized BVL Name: YX-2-233 (MDM2:RG7112 --- CDK4:palbociclib)	-
33598	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Zhao B (2019)	30758029	256623	10770	Bivalent ligand 541	pal-pom|bivalent_ligand_541	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: pal-pom (CRBN:pomalidomide --- CDK6:palbociclib)	-
33600	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Zhao B (2019)	30758029	256623	10770	Bivalent ligand 541	pal-pom|bivalent_ligand_541	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: pal-pom (CRBN:pomalidomide --- CDK4:palbociclib)	-
33602	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Zhao B (2019)	30758029	256623	10771	Bivalent ligand 542	rib-pom|bivalent_ligand_542	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: rib-pom (CRBN:pomalidomide --- CDK6:ribociclib)	-
33604	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Zhao B (2019)	30758029	256623	10771	Bivalent ligand 542	rib-pom|bivalent_ligand_542	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: rib-pom (CRBN:pomalidomide --- CDK4:ribociclib)	-
33622	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Verano AL (2022)	36007246	256625	10781	Bivalent ligand 552	ALV-07-082-03|bivalent_ligand_552	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: ALV-07-082-03 (CRBN: DKY709 --- CDK4:palbociclib)	-
33624	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Verano AL (2022)	36007246	256625	10781	Bivalent ligand 552	ALV-07-082-03|bivalent_ligand_552	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: ALV-07-082-03 (CRBN: DKY709 --- CDK6:palbociclib)	-
33652	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Cheng W (2021)	34788776	254514	10794	Bivalent ligand 565	ha-PROTAC 13|bivalent_ligand_565	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: ha-PROTAC 13 (CRBN:lenalidomide --- EGFRDel19:HALG-gefitinib 4-anilinoquinazoline core)	-
33654	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Cheng W (2021)	34788776	254514	10795	Bivalent ligand 566	PROTAC 11|bivalent_ligand_566	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC 11 (CRBN:lenalidomide --- EGFRDel19:gefitinib 4-anilinoquinazoline core)	-
33672	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Miller DSJ (2022)	35814929	256633	10804	Bivalent ligand 575	CST905|bivalent_ligand_575	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CST905 (VHL:VH032 --- BRAF:PLX7683)	-
33716	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Wu X (2021)	34568836	254526	10817	Bivalent ligand 588	MS140|bivalent_ligand_588	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MS140 (CRBN:pomalidomide --- CDK4:Palbociclib)	-
33718	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Wu X (2021)	34568836	254526	10817	Bivalent ligand 588	MS140|bivalent_ligand_588	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MS140 (CRBN:pomalidomide --- CDK6:Palbociclib)	-
33774	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Kumarasamy V (2023)	37626264	254608	10845	Bivalent ligand 624	BSJ-02-162|bivalent_ligand_624	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-02-162 (CRBN:pomalidomide --- CDK4:palbociclib)	-
33776	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Kumarasamy V (2023)	37626264	254608	10845	Bivalent ligand 624	BSJ-02-162|bivalent_ligand_624	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-02-162 (CRBN:pomalidomide --- CDK6:palbociclib)	-
33791	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	Xie H (2023)	37572533	254628	10852	Bivalent ligand 631	E-3P-MDM2|bivalent_ligand_631	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	108446	2146	-	EZH2	ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2	9606	Homo sapiens	target	Standardized BVL Name: E-3P-MDM2 (MDM2:Nutlin-3 --- EZH2:Tazemetostat (EPZ6438))	-
33793	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	Xie H (2023)	37572533	254628	10853	Bivalent ligand 632	E-4P-MDM2|bivalent_ligand_632	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	108446	2146	-	EZH2	ENX-1|ENX1|EZH1|EZH2b|KMT6|KMT6A|WVS|WVS2	9606	Homo sapiens	target	Standardized BVL Name: E-4P-MDM2 (MDM2:Nutlin-3 --- EZH2:Tazemetostat (EPZ6438))	-
33864	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Ody BK (2023)	37625128	254777	10880	Bivalent ligand 659	HaloPROTAC-4b|bivalent_ligand_659	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	HaloPROTAC	PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety--linker--HaloTag binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: HaloPROTAC-4b (CRBN:pomalidomide --- EGFR:EGFP-HaloTag2)	-
33866	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Ody BK (2023)	37625128	254777	10881	Bivalent ligand 660	HaloPROTAC-5c|bivalent_ligand_660	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	HaloPROTAC	PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety--linker--HaloTag binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: HaloPROTAC-5c (CRBN:pomalidomide --- EGFR:EGFP-HaloTag2)	-
33868	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Ody BK (2023)	37625128	254777	10882	Bivalent ligand 661	HaloPROTAC-3|bivalent_ligand_661	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	HaloPROTAC	PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety--linker--HaloTag binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: HaloPROTAC-3 (VHL:degradation moiety B --- EGFR:EGFP-HaloTag2)	-
33944	108551	2260	-	FGFR1	BFGFR|CD331|CEK|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1	9606	Homo sapiens	degradation	target	Du G (2021)	33915015	255461	10918	Bivalent ligand 697	DGY-09-192|bivalent_ligand_697	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DGY-09-192 (VHL:VHL ligand --- FGFR1:BGJ398)	-
33950	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Zhang H (2022)	35178183	255463	10920	Bivalent ligand 699	Compound 6h|bivalent_ligand_699	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: Compound 6h (VHL:VHL ligand --- EGFR Del19/T790M/C797S:brigatinib analog 3)	-
33964	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	target	Wang B (2021)	33862513	232662	10928	Bivalent ligand 707	WB214|bivalent_ligand_707	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: WB214 (CRBN:lenalidomide --- MDM2:MDM2 Ugi ligand 1)	-
34028	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Yu X (2023)	36712232	256662	10954	Bivalent ligand 733	PS-RC-1|bivalent_ligand_733	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PS-RC-1 (CRBN:pomalidomide ---IKZF1:pomalidomide)	-
34032	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Yu X (2023)	36712232	256662	10955	Bivalent ligand 734	PS-1|bivalent_ligand_734	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PS-1 (CRBN:pomalidomide ---IKZF1:pomalidomide)	-
34036	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Yu X (2023)	36712232	256662	10956	Bivalent ligand 735	PS-2|bivalent_ligand_735	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PS-2 (CRBN:pomalidomide ---IKZF1:pomalidomide)	-
34110	115604	10320	tcag7.1178	IKZF1	Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1	9606	Homo sapiens	degradation	target	Kim SA (2019)	30684871	220042	10976	Bivalent ligand 755	TD-106|bivalent_ligand_755	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Molecular Glue	Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TD-106 (CRBN:TD-106 --- IKZF1:TD-106)	-
34120	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Kim Y (2023)	37567174	256416	10978	Bivalent ligand 757	KYH1872/Compound 26|bivalent_ligand_757	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	117123	23588	-	KLHDC2	HCLP-1|HCLP1|LCP	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: KYH1872 (KLHDC2:SelK peptide --- CDK4:YHJ1039)	-
34122	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Kim Y (2023)	37567174	256416	10978	Bivalent ligand 757	KYH1872/Compound 26|bivalent_ligand_757	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	117123	23588	-	KLHDC2	HCLP-1|HCLP1|LCP	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: KYH1872 (KLHDC2:SelK peptide --- CDK6:YHJ1039)	-
34132	107454	1019	-	CDK4	CMM3|PSK-J3	9606	Homo sapiens	degradation	target	Pu C (2023)	37276679	256431	10982	Bivalent ligand 761	compound A4|bivalent_ligand_761	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	120224	54876	-	DCAF16	C4orf30	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound A4 (DCAF16:KB02 --- CDK4:Palbociclib)	-
34134	107456	1021	-	CDK6	MCPH12|PLSTIRE	9606	Homo sapiens	degradation	target	Pu C (2023)	37276679	256431	10982	Bivalent ligand 761	compound A4|bivalent_ligand_761	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	120224	54876	-	DCAF16	C4orf30	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound A4 (DCAF16:KB02 --- CDK6:Palbociclib)	-
34173	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	Cui J (2023)	37175323	256446	10996	Bivalent ligand 775	XR-4|bivalent_ligand_775	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	target	Standardized BVL Name: XR-4 (MDM2:Compound 2 (spiroindolinone pyrrolidinecarboxamide Nutlin-3 derivative) --- MDM2:Compound 2 (spiroindolinone pyrrolidinecarboxamide Nutlin-3 derivative))	-
34237	110358	4193	-	MDM2	ACTFS|HDMX|hdm2	9606	Homo sapiens	degradation	recruited e3 ligase	Chang M (2022)	36910255	256500	11022	Bivalent ligand 800	BMM4|bivalent_ligand_800	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	107070	598	RP5-857M17.3	BCL2L1	BCL-XL/S|BCL2L|BCLX|BCLXL|BCLXS|Bcl-X|PPP1R52|bcl-xL|bcl-xS	9606	Homo sapiens	target	Standardized BVL Name: BMM4 (MDM2:Nutlin-3 --- BCL-XL:ABT-263)	-
34240	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Cheng W (2023)	36906965	256503	11023	Bivalent ligand 801	ha-PROTAC 9|bivalent_ligand_801	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: ha-PROTAC 9 (CRBN:HALG-lenalidomide --- EGFRDel19:target ligand)	-
34242	108276	1956	-	EGFR	ERBB|ERBB1|HER1|NISBD2|PIG61|mENA	9606	Homo sapiens	degradation	target	Cheng W (2023)	36906965	256503	11024	Bivalent ligand 802	ha-PROTAC 10|bivalent_ligand_802	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: ha-PROTAC 10 (CRBN:HALG-lenalidomide --- EGFRDel19:target ligand)	-
