#BioGRID Chemical Interaction ID	BioGRID Gene ID	Entrez Gene ID	Systematic Name	Official Symbol	Synonyms	Organism ID	Organism	Action	Interaction Type	Author	Pubmed ID	BioGRID Publication ID	BioGRID Chemical ID	Chemical Name	Chemical Synonyms	Chemical Brands	Chemical Source	Chemical Source ID	Molecular Formula	Chemical Type	ATC Codes	CAS Number	Curated By	Method	Method Description	Related BioGRID Gene ID	Related Entrez Gene ID	Related Systematic Name	Related Official Symbol	Related Synonyms	Related Organism ID	Related Organism	Related Type	Notes	InChIKey
33057	4383849	43740578	GU280_gp01	ORF1ab	ORF1ab polyprotein|1ab|SARS-CoV2 ORF1ab|SARS-CoV-2 ORF1ab|Replicase|R1AB_SARS2|PRO_0000449618	2697049	Severe acute respiratory syndrome coronavirus 2	antiviral	target	Haniff HS (2020)	33140033	246252	10384	Bivalent ligand 488	C5-RIBOTAC|Bivalent_ligand_488	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	RIBOTAC	Ribonuclease Targeting Chimera; structured as a ribonuclease recruiting moiety-linker-RNA binding moiety	111969	6041	RP11-20H6.1	RNASEL	PRCA1|RNS4	9606	Homo sapiens	recruited ribonuclease	Standardized BVL Name: C5-RIBOTAC (RNASEL:heterocyclic RNase L-recruiting molecule --- Orf1ab:C5; Coronavirus Project; Target UniProt ID PRO_0000449618 (ORF1ab))	-
33059	4383845	43740570	GU280_gp04	E	env|envelope|SARS-CoV2 E|E protein|emp|SARS-CoV-2 E|VEMP_SARS2|PRO_0000449651	2697049	Severe acute respiratory syndrome coronavirus 2	degradation 	target	Su X (2021)	34278671	246253	10383	Bivalent ligand 489	Chimera-E|Bivalent_ligand_489	-	BIOGRID	-	-	polypeptidic	-	-	BIOGRID	RIBOTAC	Ribonuclease Targeting Chimera; structured as a ribonuclease recruiting moiety-linker-RNA binding moiety	111969	6041	RP11-20H6.1	RNASEL	PRCA1|RNS4	9606	Homo sapiens	recruited ribonuclease	Standardized BVL Name: ChimeraE (RNASEL:4A25 --- E: complementary oligonucleotide sequence; Coronavirus Project; Target UniProt ID PRO_0000449651 (E))	-
33061	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	antiviral	target	Su X (2021)	34278671	246253	10419	Bivalent ligand 490	Chimera-S4|Bivalent_ligand_490	-	BIOGRID	-	-	polypeptidic	-	-	BIOGRID	RIBOTAC	Ribonuclease Targeting Chimera; structured as a ribonuclease recruiting moiety-linker-RNA binding moiety	111969	6041	RP11-20H6.1	RNASEL	PRCA1|RNS4	9606	Homo sapiens	recruited ribonuclease	Standardized BVL Name: ChimeraS4 (RNASEL:4A25 --- S:complementary oligonucleotide sequence; Coronavirus Project; Target UniProt ID PRO_0000449646 (S))	-
33063	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	antiviral	target	Chatterjee P (2020)	33230174	239810	10425	Bivalent ligand 491	23-mer|Bivalent_ligand_491	-	BIOGRID	-	-	polypeptidic	-	-	BIOGRID	bioPROTAC	Engineered intracellular proteins consisting of a target-binding domain directly fused to an E3 ubiquitin ligase; NOTE: the format for this BVL name is (E3:GFP binding scaffold fusion --- Target:GFP fusion)	112615	6737	-	TRIM21	RNF81|RO52|Ro/SSA|SSA|SSA1	9606	Homo sapiens	recruited e3 ligase	The authors fused the RBD-binding proteins to the CHIPTPR modified E3 ubiquitin ligase domain to prevent circumvent the need to express Trim21 in trans|Standardized BVL Name: 23-mer (A2N)-CHIPTPR (TRIM21:NA --- S RBD domain: sACE2 derived 23-mer (A2N) peptide; Coronavirus Project; Target UniProt ID PRO_0000449646 (S))	-
33065	4383849	43740578	GU280_gp01	ORF1ab	ORF1ab polyprotein|1ab|SARS-CoV2 ORF1ab|SARS-CoV-2 ORF1ab|Replicase|R1AB_SARS2|PRO_0000449618	2697049	Severe acute respiratory syndrome coronavirus 2	degradation/antiviral	target	Alugubelli YR (2023)	888800001046	245523	10426	Bivalent ligand 492	antiviral MDP2|Bivalent_ligand_492	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: antiviral MDP2 (CRBN:thalidomide---Nsp5/MPro:MPI8; Coronavirus Project; Target UniProt ID PRO_0000449623 (nsp5))	-
33088	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Gordon CJ (2020)	32284326	239594	9968	Remdesivir	L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile|Veklury|remdesivir|UNII:3QKI37EEHE|GS-5734|2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name)	-	CHEMSPIDER	58827832	C27H35N6O8P	small molecule	-	1809249-37-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor	RWWYLEGWBNMMLJ-YSOARWBDSA-N
33089	4383949	1489680	SARS-CoV-1ab-nsp12ab	nsp12ab	nsp12|sars1ab|orf1ab|SARS-CoV nsp12ab|SARS-CoV nsp12|SARS-CoV sars1ab|orf1ab-nsp12|orf1ab-nsp12ab|pp1ab|RNA-directed RNA polymerase|Pol|RdRp|R1AB_CVHSA|PRO_0000037318	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Agostini ML (2018)	29511076	222024	9968	Remdesivir	L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile|Veklury|remdesivir|UNII:3QKI37EEHE|GS-5734|2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name)	-	CHEMSPIDER	58827832	C27H35N6O8P	small molecule	-	1809249-37-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor; antiviral activity against SARS-CoV-2 in HAE cultures	RWWYLEGWBNMMLJ-YSOARWBDSA-N
33090	4383896	14254602	G128_gp01ab_nsp12	nsp12ab	ORF1ab|nsp12|rep|1AB|MERS-CoV nsp12|orf1ab-nsp12|orf1ab-nsp12ab|nsp12ab|RNA polymerase|R1AB_CVEMC|PRO_0000422449	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor/mers-cov inhibitor	target	Agostini ML (2018)	29511076	222024	9968	Remdesivir	L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile|Veklury|remdesivir|UNII:3QKI37EEHE|GS-5734|2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name)	-	CHEMSPIDER	58827832	C27H35N6O8P	small molecule	-	1809249-37-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor; antiviral activity against SARS-CoV-2 in HAE cultures	RWWYLEGWBNMMLJ-YSOARWBDSA-N
33091	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Kabinger F (2021)	34381216	239595	9952	Molnupiravir	3,4-Dihydrocytidine, N-hydroxy-, 5'-(2-methylpropanoate)|N-Hydroxy-5'-O-isobutyryl-3,4-dihydrocytidine|EIDD-2801|Molnupiravir	-	CHEMSPIDER	84400552	C13H19N3O7	small molecule	-	2349386-89-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor	HTNPEHXGEKVIHG-QCNRFFRDSA-N
33092	4383949	1489680	SARS-CoV-1ab-nsp12ab	nsp12ab	nsp12|sars1ab|orf1ab|SARS-CoV nsp12ab|SARS-CoV nsp12|SARS-CoV sars1ab|orf1ab-nsp12|orf1ab-nsp12ab|pp1ab|RNA-directed RNA polymerase|Pol|RdRp|R1AB_CVHSA|PRO_0000037318	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Barnard DL (2004)	15074711	239596	9952	Molnupiravir	3,4-Dihydrocytidine, N-hydroxy-, 5'-(2-methylpropanoate)|N-Hydroxy-5'-O-isobutyryl-3,4-dihydrocytidine|EIDD-2801|Molnupiravir	-	CHEMSPIDER	84400552	C13H19N3O7	small molecule	-	2349386-89-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor	HTNPEHXGEKVIHG-QCNRFFRDSA-N
33093	4383896	14254602	G128_gp01ab_nsp12	nsp12ab	ORF1ab|nsp12|rep|1AB|MERS-CoV nsp12|orf1ab-nsp12|orf1ab-nsp12ab|nsp12ab|RNA polymerase|R1AB_CVEMC|PRO_0000422449	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor/mers-cov inhibitor	target	Agostini ML (2019)	31578288	239597	9952	Molnupiravir	3,4-Dihydrocytidine, N-hydroxy-, 5'-(2-methylpropanoate)|N-Hydroxy-5'-O-isobutyryl-3,4-dihydrocytidine|EIDD-2801|Molnupiravir	-	CHEMSPIDER	84400552	C13H19N3O7	small molecule	-	2349386-89-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor	HTNPEHXGEKVIHG-QCNRFFRDSA-N
33094	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Fu Z (2021)	33473130	230134	7430	GRL0617	5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide	-	DRUGBANK	DB08656	C20H20N2O	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral PLpro papain-like protease; antiviral activity against SARS-CoV-2 in Vero E6 cells	UVERBUNNCOKGNZ-CQSZACIVSA-N
33095	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Unoh Y (2022)	35352927	239599	9978	Ensitrelvir	1,3,5-Triazine-2,4(1H,3H)-dione, 6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]dihydro-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-, (6E)-|(6E)-6-[(6-Chloro-2-methyl-2H-indazol-5-yl)imino]-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-(2,4,5-trifluorobenzyl)-1,3,5-triazinane-2,4-dione	-	CHEMSPIDER	115007411	C22H17ClF3N9O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV-2 in VeroE6/TMPRSS2 cells	QMPBBNUOBOFBFS-UHFFFAOYSA-N
33096	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Swaim CD (2021)	34632326	234511	344	Tioguanine	2-Amino-6-mercaptopurine|2-Amino-6-purinethiol|Tioguanin|2-aminopurine-6-thiol|6-TG|Tioguanine|2-amino-1,9-Dihydropurine-6-thione|2-Amino-1,7-dihydro-6H-purine-6-thione|6-Thioguanine|Thioguanine|2-Aminopurin-6-thiol|6-Mercaptoguanine|2-Amino 6mp|2-amino-1H-purine-6(7H)-thione|Tioguanina|ThG|TG|Tioguaninum|2-Amino-6-merkaptopurin|2-Aminopurine-6(1H)-thione|6-Mercapto-2-aminopurine|6-thioguanine	tabloid|lanvis	DRUGBANK	DB00352	C5H5N5S	small molecule	L01BB03	154-42-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV-2 in Vero E6 cells	WYWHKKSPHMUBEB-UHFFFAOYSA-N
33098	4383864	43740578	GU280_gp01_nsp16	nsp16	ORF1ab|ORF1ab-nsp16|SARS-CoV2 nsp16|SARS-CoV-2 nsp16|2-O-methyltransferase|R1AB_SARS2|PRO_0000449633	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Krafcikova P (2020)	32709887	238333	1836	Sinefungin	Adenosyl-ornithine|6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronic acid|(2S,5S)-2,5-diamino-6-[(2R,3S,R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]hexanoic acid|sinefunginum|6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid|sinefungina|sinefungine	-	DRUGBANK	DB01910	C15H23N7O5	small molecule	-	58944-73-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: pan-MTase inhibitor	LMXOHSDXUQEUSF-YECHIGJVSA-N
33099	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Hoffman RL (2020)	33054210	239600	9959	PF-00835231	1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-|N-[(2S)-1-({(2S)-4-Hydroxy-3-oxo-1-[(3S)-2-oxo-3-pyrrolidinyl]-2-butanyl}amino)-4-methyl-1-oxo-2-pentanyl]-4-methoxy-1H-indole-2-carboxamide	-	CHEMSPIDER	9736673	C24H32N4O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	QDIMHKWNHMVDJB-WBAXXEDZSA-N
33100	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Hoffman RL (2020)	33054210	239600	9959	PF-00835231	1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-|N-[(2S)-1-({(2S)-4-Hydroxy-3-oxo-1-[(3S)-2-oxo-3-pyrrolidinyl]-2-butanyl}amino)-4-methyl-1-oxo-2-pentanyl]-4-methoxy-1H-indole-2-carboxamide	-	CHEMSPIDER	9736673	C24H32N4O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	QDIMHKWNHMVDJB-WBAXXEDZSA-N
33101	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Dai W (2020)	32321856	239601	9982	MPro Inhibitor 11a	1H-Indole-2-carboxamide, N-[(1S)-1-(cyclohexylmethyl)-2-[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]-2-oxoethyl]-|MPro Inhibitor 11a|N-[(2S)-3-Cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxo-3-pyrrolidinyl]-2-propanyl}amino)-2-propanyl]-1H-indole-2-carboxamide|Bofutrelvir	-	CHEMSPIDER	88294718	C25H32N4O4	small molecule	-	2103278-86-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	HPKJGHVHQWJOOT-ZJOUEHCJSA-N
33102	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Dai W (2020)	32321856	239601	9981	MPro Inhibitor 11b	MPro Inhibitor 11b|3-Fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxo-3-pyrrolidinyl]-2-propanyl}-L-phenylalaninamide|1H-Indole-2-carboxamide, N-[(1S)-1-[(3-fluorophenyl)methyl]-2-[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]-2-oxoethyl]-	-	CHEMSPIDER	88294719	C25H25FN4O4	small molecule	-	2413716-71-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	HCRBVFBQANEDDM-CUWPLCDZSA-N
33103	4383950	1489680	SARS-CoV-1ab-nsp13ab	nsp13ab	nsp13|sars1ab|orf1ab|SARS-CoV nsp13ab|SARS-CoV nsp13|SARS-CoV sars1ab|orf1ab-nsp13|orf1ab-nsp13ab|pp1ab|Helicase|Hel|R1AB_CVHSA|PRO_0000037319	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Adedeji AO (2012)	22733076	239602	9957	SSYA10-001	4-allyl-5-{[(2-nitrophenyl)thio]methyl}-4H-1,2,4-triazole-3-thiol|3H-1,2,4-Triazole-3-thione, 2,4-dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-|4-Allyl-5-{[(2-nitrophenyl)sulfanyl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione	-	CHEMSPIDER	2085693	C12H12N4O2S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral helicase inhibitor	VWFIHGWHMXSTAO-UHFFFAOYSA-N
33104	4383897	14254602	G128_gp01ab_nsp13	nsp13ab	ORF1ab|nsp13|rep|1AB|MERS-CoV nsp13|orf1ab-nsp13|orf1ab-nsp13ab|nsp13ab|Helicase|R1AB_CVEMC|PRO_0000422450	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor/mers-cov inhibitor	target	Adedeji AO (2014)	24841268	239603	9957	SSYA10-001	4-allyl-5-{[(2-nitrophenyl)thio]methyl}-4H-1,2,4-triazole-3-thiol|3H-1,2,4-Triazole-3-thione, 2,4-dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-|4-Allyl-5-{[(2-nitrophenyl)sulfanyl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione	-	CHEMSPIDER	2085693	C12H12N4O2S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral helicase inhibitor	VWFIHGWHMXSTAO-UHFFFAOYSA-N
33105	4383950	1489680	SARS-CoV-1ab-nsp13ab	nsp13ab	nsp13|sars1ab|orf1ab|SARS-CoV nsp13ab|SARS-CoV nsp13|SARS-CoV sars1ab|orf1ab-nsp13|orf1ab-nsp13ab|pp1ab|Helicase|Hel|R1AB_CVHSA|PRO_0000037319	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Tanner JA (2005)	15797214	239604	9938	Bananin	AKOS016036756|BANANIN|HY-145113|CS-0356439	-	PUBCHEM	59053860	C14H17NO8	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral helicase inhibitor	-
33106	4383951	1489680	SARS-CoV-1ab-nsp14ab	nsp14ab	nsp14|sars1ab|orf1ab|SARS-CoV nsp14ab|SARS-CoV nsp14|SARS-CoV sars1ab|orf1ab-nsp14|orf1ab-nsp14ab|pp1ab|Guanine-N7 methyltransferase|ExoN|R1AB_CVHSA|PRO_0000037320	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov-2 inhibitor	target	Bouvet M (2010)	20421945	238722	9963	Aurintricarboxylic acid	ATA|Aurintricarboxylic acid|Benzoic acid, 5-((3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl)-2-hydroxy-|3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid)|3,3'-[(3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid)|3,3'-[(3-Carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis(6-hydroxybenzoic acid)|MFCD00011663	-	CHEMSPIDER	2172	C22H14O9	small molecule	-	4431-00-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: pan-MTase inhibitor	GIXWDMTZECRIJT-UHFFFAOYSA-N
33107	4383953	1489680	SARS-CoV-1ab-nsp16ab	nsp16ab	nsp16|sars1ab|orf1ab|SARS-CoV nsp16ab|SARS-CoV nsp16|SARS-CoV sars1ab|orf1ab-nsp16|orf1ab-nsp16ab|pp1ab|2-O-methyltransferase|R1AB_CVHSA|PRO_0000037322	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov-2 inhibitor	target	Bouvet M (2010)	20421945	238722	9963	Aurintricarboxylic acid	ATA|Aurintricarboxylic acid|Benzoic acid, 5-((3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl)-2-hydroxy-|3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methanediyl]bis(6-hydroxybenzoic acid)|3,3'-[(3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid)|3,3'-[(3-Carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methylene]bis(6-hydroxybenzoic acid)|MFCD00011663	-	CHEMSPIDER	2172	C22H14O9	small molecule	-	4431-00-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: pan-MTase inhibitor	GIXWDMTZECRIJT-UHFFFAOYSA-N
33113	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zhang L (2020)	32198291	221191	9984	2-Methyl-2-propanyl {1-[(2S)-1-({(2S,3R)-4-(benzylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxo-3-pyrrolidinyl]-2-butanyl}amino)-3-cyclopropyl-1-oxo-2-propanyl]-2-oxo-1,2-dihydro-3-pyridinyl}carbamate	2-Methyl-2-propanyl {1-[(2S)-1-({(2S,3R)-4-(benzylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxo-3-pyrrolidinyl]-2-butanyl}amino)-3-cyclopropyl-1-oxo-2-propanyl]-2-oxo-1,2-dihydro-3-pyridinyl}carbamate	-	CHEMSPIDER	88294383	C31H41N5O7	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	FRACPXUHUTXLCX-BELIEFIBSA-N
33114	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Peng Q (2021)	33521757	227499	10347	Favipiravir	AM20080851|EX-A2285|Z1255381648|FAVIPIRAVIR|BCPP000056|T 705,CAS;259793-96-9|FAVIPIRAVIR [USAN:INN:JAN]|6-FLUORO-3,4-DIHYDRO-3-OXO-2-PYRAZINECARBOXAMIDE; 6-FLUORO-3,4-DIHYDRO-3-OXO-PYRAZINECARBOXAMIDE; 6-FLUORO-3-HYDROXY-2-PYRAZINECARBOXAMIDE; FAVIPIRAVIR; T 705; T 705 (PHARMACEUTICAL)|SY110833|AVIPIRAVIR|AKOS005166863|FAVIPIRA|FT-0701282|6-FLUORO-3,4-DIHYDRO-3-OXO-2-PYRAZINECARBOXAMIDE|A25520|6-FLUORO-3-HYDROXY-PYRAZINE-2-CARBOXAMIDE|ZCGNOVWYSGBHAU-UHFFFAOYSA-N|AVIGAN (TN)|J-518718|EN300-1601539|6-FLUORO-3-OXO-3,4-DIHYDROPYRAZINE-2-CARBOXAMIDE|FT-0686297|FAVIPIRAVIR [WHO-DD]|T-705|FAVIPIRAVIRUM|5-FLUORO-2-OXO-1H-PYRAZINE-3-CARBOXAMIDE|FAVIPIRAVIR [MI]|259793-96-9|EW5GL2X7E0|DTXSID60948878|FAVIPIRAVIR [INN]|D09537|6-FLUORO-3-HYDROXYPYRAZINE-2-CARBO XAMIDE|CS-0612|PB42412|6-FLUORO-3-HYDROXYPYRAZINE-2-CARBOXAMIDE|FAPILAVIR|HY-14768|AVIGAN|PYRAZINECARBOXAMIDE, 6-FLUORO-3,4-DIHYDRO-3-OXO-|DB12466|FAVILAVIR|Q16934561|6-FLUORO-3-HYDROXY-2-PYRAZINECARBOXAMIDE|A902150|T 705|AREPLIVIR|FAVIPIRAVIR [JAN]|NCGC00373041-03|T-705 CPD|AC-28900|T705|BCP02422|6-FLUORO-3,4-DIHYDRO-3-OXO-PYRAZINECARBOXAMIDE|GTPL11139|UNII-EW5GL2X7E0|CCG-266269|S7975|FAVIPIRAVIR (T-705)|AKOS015995178|PB25591|NCGC00373041-06|FAVIPIRAVIR; T-705|2-PYRAZINECARBOXAMIDE, 6-FLUORO-3-HYDROXY-|J05AX27|MFCD12032148|MS-20791|AVIFAVIR|FAVIPIRAVIR [USAN]|FAVIPIRAVIR (JAN/USAN/INN)	-	PUBCHEM	492405	C5H4FN3O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor	ZCGNOVWYSGBHAU-UHFFFAOYSA-N
33115	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Hattori SI (2021)	33510133	239605	9939	GRL-1720	GRL-1720|INDOLE CHLOROPYRIDINYL-ESTER DERIVED, 2|Indole chloropyridinyl-ester derived, 2	-	PUBCHEM	156600307	C14H11ClN2O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	-
33117	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Iqbal S (2023)	37627846	238898	9940	F1877-0839	F1877-0839|AKOS024616227|872595-28-3|1-(3-METHOXYPHENYL)-5-OXO-N-[5-[2-OXO-2-(1,3-THIAZOL-2-YLAMINO)ETHYL]SULFANYL-1,3,4-THIADIAZOL-2-YL]PYRROLIDINE-3-CARBOXAMIDE|1-(3-METHOXYPHENYL)-5-OXO-N-(5-((2-OXO-2-(THIAZOL-2-YLAMINO)ETHYL)THIO)-1,3,4-THIADIAZOL-2-YL)PYRROLIDINE-3-CARBOXAMIDE|1-(3-METHOXYPHENYL)-5-OXO-N-[5-({[(1,3-THIAZOL-2-YL)CARBAMOYL]METHYL}SULFANYL)-1,3,4-THIADIAZOL-2-YL]PYRROLIDINE-3-CARBOXAMIDE|1-(3-methoxyphenyl)-5-oxo-N-(5-((2-oxo-2-(thiazol-2-ylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxamide	-	PUBCHEM	16832490	C19H18N6O4S3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined. Authors identified SARS-CoV-2 (WT) Spike inhibitors using experimental ACE2 Inhibition TR-FRET Assay, high throughput Screening and Molecular Dynamic Simulation (MDS).	-
33118	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Iqbal S (2023)	37627846	238898	9941	F0470-0003	3-(2-CHLOROPHENYL)-5-METHYL-N-(5-((2-OXO-2-(THIAZOL-2-YLAMINO)ETHYL)THIO)-1,3,4-THIADIAZOL-2-YL)ISOXAZOLE-4-CARBOXAMIDE|AKOS002046982|391868-57-8|ZINC16977044|3-(2-CHLOROPHENYL)-5-METHYL-N-(5-{[2-OXO-2-(1,3-THIAZOL-2-YLAMINO)ETHYL]THIO}-1,3,4-THIADIAZOL-2-YL)ISOXAZOLE-4-CARBOXAMIDE|3-(2-CHLOROPHENYL)-5-METHYL-N-[5-({[(1,3-THIAZOL-2-YL)CARBAMOYL]METHYL}SULFANYL)-1,3,4-THIADIAZOL-2-YL]-1,2-OXAZOLE-4-CARBOXAMIDE|F0470-0003|OPREA1_347251|3-(2-CHLOROPHENYL)-5-METHYL-N-[5-[2-OXO-2-(1,3-THIAZOL-2-YLAMINO)ETHYL]SULFANYL-1,3,4-THIADIAZOL-2-YL]-1,2-OXAZOLE-4-CARBOXAMIDE|3-(2-chlorophenyl)-5-methyl-N-(5-((2-oxo-2-(thiazol-2-ylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)isoxazole-4-carboxamide	-	PUBCHEM	4564796	C18H13ClN6O3S3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined. Authors identified SARS-CoV-2 (WT) Spike inhibitors using experimental ACE2 Inhibition TR-FRET Assay, high throughput Screening and Molecular Dynamic Simulation (MDS).	-
33119	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Kato Y (2021)	888800000233	227570	1230	Clomipramine	Clomipraminum|3-Chloroimipramine|Monochlorimipramine|3-(3-chloro-10,11-dihydro-5H-Dibenzo[b,F]azepin-5-yl)-N,N-dimethyl-1-propanamine|Clomipramine|Clomipramina|g 34586|Chlorimipramine|3-(3-CHLORO-5H-dibenzo[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine	gen-clomipramine - tab 50mg|pm	DRUGBANK	DB01242	C19H23ClN2	small molecule	N06AA04	303-49-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (computational)	GDLIGKIOYRNHDA-UHFFFAOYSA-N
33120	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Srinivasan V (2022)	35953531	238809	9983	4-(2-hydroxyethyl)phenol	Tyrosol|Benzeneethanol, 4-hydroxy-|4-Hydroxyphenylethanol|4-(2-Hydroxyethyl)phenol|p-Hydroxyphenethyl alcohol|2-(4-Hydroxyphenyl)ethanol|4-Hydroxyphenethyl alcohol|4-Hydroxyphenylethyl alcohol|b-(4-Hydroxyphenyl)ethanol|b-(p-Hydroxyphenyl)ethanol|beta-(4-Hydroxyphenyl)ethanol|beta-(p-Hydroxyphenyl)ethanol|4-(2-Hydroxyethyl)benzolol|2-(4-Hydroxyphenyl)ethan-1-ol|phenethyl alcohol, 4-hydroxy-|p-Hydroxyphenylethanol|Ethanol, 2-(4-hydroxyphenyl)-|4-hydroxy-Benzeneethanol|UNII-1AK4MU3SNX|p-HPEA|1AK4MU3SNX	-	CHEMSPIDER	9964	C8H10O2	small molecule	-	501-94-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	YCCILVSKPBXVIP-UHFFFAOYSA-N
33121	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Srinivasan V (2022)	35953531	238809	9953	Methyl 3,4-dihydroxybenzoate	Methyl 3,4-dihydroxybenzoate|Protocatechuic acid, methyl ester|Benzoic acid, 3,4-dihydroxy-, methyl ester|methyl esterprotocatechuic acid	-	CHEMSPIDER	253113	C8H8O4	small molecule	-	2150-43-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	CUFLZUDASVUNOE-UHFFFAOYSA-N
33122	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Grosse M (2022)	35891385	238812	8389	PR-619	2,6-diamino-5-(cyanothio)pyridin-3-yl thiocyanate|2,6-Diamino-3,5-pyridinediyl bis(thiocyanate)|Thiocyanic acid, 2,6-diamino-3,5-pyridinediyl ester	-	CHEMSPIDER	2096054	C7H5N5S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	ZXOBLNBVNROVLC-UHFFFAOYSA-N
33123	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Grosse M (2022)	35891385	238812	8385	HBX 41,108	7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile|9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo-	-	CHEMSPIDER	17225370	C13H3ClN4O	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	BIGPXXAUSQLTQR-UHFFFAOYSA-N
33124	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Zou Z (2022)	35866602	238813	9970	Parthenolide	Parthenolide|(1aR,4E,7aS,10aS,10bR)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one|Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bR)-|(-)-Parthenolide|(1aR,4E,7aS,10aS,10bR)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one	-	CHEMSPIDER	4976071	C15H20O3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	KTEXNACQROZXEV-PVLRGYAZSA-N
33125	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Ma C (2021)	34341772	227572	10346	Jun9-72-2	Phenol, 4-[[methyl[(1R)-1-(1-naphthalenyl)ethyl]amino]methyl]-|4-({Methyl[(1R)-1-(1-naphthyl)ethyl]amino}methyl)phenol	-	CHEMSPIDER	115285268	C20H21NO	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	QFTKMDZKABQMHI-OAHLLOKOSA-N
33126	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Shan H (2021)	33979649	239606	9942	GTPL11543	N-{3-FLUORO-5-[({1-[(1R)-1-(NAPHTHALEN-1-YL)ETHYL]PIPERIDIN-4-YL}FORMAMIDO)METHYL]PHENYL}-4-METHYLPIPERAZINE-1-CARBOXAMIDE|GTPL11543|COMPOUND 19 [PMID: 33979649]|N-{3-fluoro-5-[({1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidin-4-yl}formamido)methyl]phenyl}-4-methylpiperazine-1-carboxamide	-	PUBCHEM	155925847	C31H38FN5O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	-
33127	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	9975	Asunaprevir	1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate|Asunaprevir|Cyclopropanecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)-|3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-L-prolinamide|L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-[(1R,2S)-1-[[(cyclopropylsulfonyl)amino]carbonyl]-2-ethenylcyclopropyl]-, (4R)-|UNII-S9X0KRJ00S|S9X0KRJ00S	-	CHEMSPIDER	17235944	C35H46ClN5O9S	small molecule	-	630420-16-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	XRWSZZJLZRKHHD-WVWIJVSJSA-N
33128	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	5547	Simeprevir	-	galexos|olysio	DRUGBANK	DB06290	C38H47N5O7S2	small molecule	J05AE14	923604-59-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	JTZZSQYMACOLNN-VDWJNHBNSA-N
33129	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	9976	Vaniprevir	Vaniprevir|Vaniprevirum|CV3X74AO1H	-	CHEMSPIDER	28475381	C38H55N5O9S	small molecule	-	923590-37-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	KUQWGLQLLVFLSM-ONAXAZCASA-N
33130	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	9965	Narlaprevir	Narlaprevir|2857LA2O07	-	CHEMSPIDER	10031710	C36H61N5O7S	small molecule	-	865466-24-6	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	RICZEKWVNZFTNZ-LFGITCQGSA-N
33131	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	8249	Grazoprevir	(1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide|Grazoprevir|Grazoprevir anhydrous	zepatier	DRUGBANK	DB11575	C38H50N6O9S	small molecule	-	1350514-68-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	OBMNJSNZOWALQB-NCQNOWPTSA-N
33132	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	7617	Boceprevir	Victrelis|SCH 503034	victrelis triple|victrelis	DRUGBANK	DB08873	C27H45N5O5	small molecule	J05AE12	394730-60-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	LHHCSNFAOIFYRV-DOVBMPENSA-N
33133	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	5272	Telaprevir	(1S,3AR,6as)-(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta(c)pyrrole-1-carboxamide|MP-424|VX 950|Incivek|VX-950	incivek	DRUGBANK	DB05521	C36H53N7O6	small molecule	J05AE11	402957-28-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	BBAWEDCPNXPBQM-GDEBMMAJSA-N
33134	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	8041	Paritaprevir	(2R,6S,12Z,13aR,14aR,16aS)-N-(cyclopropanesulfonyl)-6-[(5-methylpyrazine-2-carbonyl)amino]-5,16-dioxo-2-[(phenanthridin-6-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide|Veruprevir	technivie|viekira pak|holkira 	DRUGBANK	DB09297	C40H43N7O7S	small molecule	J05AX67|J05AX66	1216941-48-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	UAUIUKWPKRJZJV-MDJGTQRPSA-N
33135	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	8249	Grazoprevir	(1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide|Grazoprevir|Grazoprevir anhydrous	zepatier	DRUGBANK	DB11575	C38H50N6O9S	small molecule	-	1350514-68-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	OBMNJSNZOWALQB-NCQNOWPTSA-N
33136	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	5547	Simeprevir	-	galexos|olysio	DRUGBANK	DB06290	C38H47N5O7S2	small molecule	J05AE14	923604-59-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	JTZZSQYMACOLNN-VDWJNHBNSA-N
33137	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bafna K (2021)	33984267	239607	9976	Vaniprevir	Vaniprevir|Vaniprevirum|CV3X74AO1H	-	CHEMSPIDER	28475381	C38H55N5O9S	small molecule	-	923590-37-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	KUQWGLQLLVFLSM-ONAXAZCASA-N
33138	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Drayman N (2021)	34285133	239608	9977	Masitinib	Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-|4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide|Masitinib|N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide|4-[(4-Methyl-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-1,3-thiazol-2-yl]amino}phenyl)benzamide	-	CHEMSPIDER	8250179	C28H30N6OS	small molecule	-	790299-79-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	WJEOLQLKVOPQFV-UHFFFAOYSA-N
33139	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Logan A (2022)	888800000762	238022	9936	LMW-DS	Ibsolvmir|Dextran sulfate sodium	-	PUBCHEM	440234653	-	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined; Delta, omicron and wuhan variant tested	-
33140	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Ma C (2020)	32541865	239609	7617	Boceprevir	Victrelis|SCH 503034	victrelis triple|victrelis	DRUGBANK	DB08873	C27H45N5O5	small molecule	J05AE12	394730-60-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	LHHCSNFAOIFYRV-DOVBMPENSA-N
33141	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Ma C (2020)	32541865	239609	9944	GC-376	BCP32603|GC-376; GC 376|GC376|(2S)-1-hydroxy-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate	-	PUBCHEM	146681255	C21H30N3O8S-	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	-
33142	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Ma C (2020)	32541865	239609	9967	Calpain Inhibitor II	Calpain inhibitor II|N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxo-2-butanyl]-L-leucinamide|N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide|SUAM-312|MFCD00065506|1D8SBU367Z|N-Acetyl-L-leucyl-N-[(2S)-4-(methylsulfanyl)-1-oxobutan-2-yl]-L-leucinamide|L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-|N-Acetyl-L-leucyl-L-leucyl-L-methioninal	-	CHEMSPIDER	108711	C19H35N3O4S	small molecule	-	136632-32-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	RJWLAIMXRBDUMH-ULQDDVLXSA-N
33143	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Ma C (2020)	32541865	239609	9979	Calpain Inhibitor XII	Calpain Inhibitor XII|Carbamic acid, N-[1-[[[1-[1,2-dioxo-2-[(2-pyridinylmethyl)amino]ethyl]butyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester|N~2~-[(benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(pyridin-2-ylmethyl)amino]hexan-3-yl}leucinamide|N~2~-[(Benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(2-pyridinylmethyl)amino]-3-hexanyl}leucinamide	-	CHEMSPIDER	21396054	C26H34N4O5	small molecule	-	181769-57-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	PLVWMBFPIAQRHK-UHFFFAOYSA-N
33144	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Kitamura N (2022)	33891389	239610	9945	JUN8763A	N-([1,1'-BIPHENYL]-4-YL)-N-((R)-2-OXO-2-(((S)-1-PHENYLETHYL)AMINO)-1-(PYRIDIN-3-YL)ETHYL)FURAN-2-CARBOXAMIDE|GLXC-25592|X7V|JUN8-76-3A|N-([1,1'-BIPHENYL]-4-YL)-N-[(1R)-2-OXO-2-{[(1S)-1-PHENYLETHYL]AMINO}-1-(PYRIDIN-3-YL)ETHYL]FURAN-2-CARBOXAMIDE|JUN8763A|N-([1,1'-biphenyl]-4-yl)-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]furan-2-carboxamide|JUN8-76-3A	-	PUBCHEM	155289416	C32H27N3O3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	-
33145	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Campagna J (2022)	888800000722	237482	5530	Eltrombopag	Promacta|Eltrombopagum|Eltrombopag	revolade|promacta	DRUGBANK	DB06210	C25H22N4O4	small molecule	B02BX05	496775-61-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	XDXWLKQMMKQXPV-QYQHSDTDSA-N
33151	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Papp H (2022)	888800000685	237180	8302	Rucaparib	-	rubraca	DRUGBANK	DB12332	C19H18FN3O	small molecule	-	283173-50-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (experimental);	HMABYWSNWIZPAG-UHFFFAOYSA-N
33153	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Jochmans D (2023)	36625640	236293	9959	PF-00835231	1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-|N-[(2S)-1-({(2S)-4-Hydroxy-3-oxo-1-[(3S)-2-oxo-3-pyrrolidinyl]-2-butanyl}amino)-4-methyl-1-oxo-2-pentanyl]-4-methoxy-1H-indole-2-carboxamide	-	CHEMSPIDER	9736673	C24H32N4O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	QDIMHKWNHMVDJB-WBAXXEDZSA-N
33154	4383849	43740578	GU280_gp01	ORF1ab	ORF1ab polyprotein|1ab|SARS-CoV2 ORF1ab|SARS-CoV-2 ORF1ab|Replicase|R1AB_SARS2|PRO_0000449618	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Roy SS (2022)	888800000660	236299	469	Chlorpromazine	Chlorpromazine|Chloropromazine|Largactil|CPZ|N-(3-Dimethylaminopropyl)-3-chlorophenothiazine|Aminazine|Chlorpromados|Chlorpromazinum|Clorpromazina|Chlorderazin|3-(2-chloro-10H-Phenothiazin-10-yl)-N,N-dimethyl-1-propanamine|Contomin|3-(2-Chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine|Thorazine	chlorpromanyl 20 syr|chlorprom	DRUGBANK	DB00477	C17H19ClN2S	small molecule	N05AA01	50-53-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: ORF1 G4 binding	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
33155	4383849	43740578	GU280_gp01	ORF1ab	ORF1ab polyprotein|1ab|SARS-CoV2 ORF1ab|SARS-CoV-2 ORF1ab|Replicase|R1AB_SARS2|PRO_0000449618	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Roy SS (2022)	888800000660	236299	425	Prochlorperazine	3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine|Prochlorperazinum|Procloperazine|Prochlorpromazine|Prochlorprazine|3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine|Prochlorpermazine|Capazine|Emetiral|Chloropernazine|2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine|N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine|Proclorperazina|Chlormeprazine|2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine|Prochlorperazin|Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine	prochlorperazine maleate|sando	DRUGBANK	DB00433	C20H24ClN3S	small molecule	N05AB04	58-38-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: ORF1 G4 binding	WIKYUJGCLQQFNW-UHFFFAOYSA-N
33156	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Hirose Y (2022)	36229406	236284	9946	8a (YH-6)	8a (YH-6)|4-fluoro-N-[(2S)-1-[2-(2-fluoroacetyl)-2-[[(3S)-2-oxopyrrolidin-3-yl]methyl]hydrazinyl]-4-methyl-1-oxopentan-2-yl]-1H-indole-2-carboxamide	-	PUBCHEM	165416578	C22H27F2N5O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	-
33157	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Hirose Y (2022)	36229406	236284	9946	8a (YH-6)	8a (YH-6)|4-fluoro-N-[(2S)-1-[2-(2-fluoroacetyl)-2-[[(3S)-2-oxopyrrolidin-3-yl]methyl]hydrazinyl]-4-methyl-1-oxopentan-2-yl]-1H-indole-2-carboxamide	-	PUBCHEM	165416578	C22H27F2N5O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	-
33158	4383890	14254602	G128_gp01ab_nsp5	nsp5ab	ORF1ab|nsp5|rep|1AB|MERS-CoV nsp5|orf1ab-nsp5|orf1ab-nsp5ab|nsp5ab|3C-like proteinase|R1AB_CVEMC|PRO_0000422443	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor/mers-cov inhibitor	target	Hirose Y (2022)	36229406	236284	9946	8a (YH-6)	8a (YH-6)|4-fluoro-N-[(2S)-1-[2-(2-fluoroacetyl)-2-[[(3S)-2-oxopyrrolidin-3-yl]methyl]hydrazinyl]-4-methyl-1-oxopentan-2-yl]-1H-indole-2-carboxamide	-	PUBCHEM	165416578	C22H27F2N5O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	-
33160	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Raymonda MH (2022)	34871905	239614	1246	Lapatinib	GW 572016|N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine|Lapatinib tosilate hydrate|N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine|FMM|Tykerb	tykerb	DRUGBANK	DB01259	C29H26ClFN4O4S	small molecule	L01XE07	231277-92-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	BCFGMOOMADDAQU-UHFFFAOYSA-N
33167	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Hu H (2022)	36308706	239366	10348	Tetramethylcystamine	Ethanamine, 2,2'-dithiobis[N,N-dimethyl-|2,2'-DITHIOBIS(N,N-DIMETHYLETHANAMINE)|ETHANAMINE, 2,2'-DITHIOBIS(N,N-DIMETHYL-|DTXSID30147932|TMTS|BIS[2-(N,N-DIMETHYLAMINO)ETHYL]DISULFIDE|N-(2-([2-(DIMETHYLAMINO)ETHYL]DISULFANYL)ETHYL)-N,N-DIMETHYLAMINE #|N,N'-TETRAMETHYLCYSTAMINE|ETHANAMINE, 2,2'-DITHIOBIS[N,N-DIMETHYL-|2-[2-(DIMETHYLAMINO)ETHYLDISULFANYL]-N,N-DIMETHYLETHANAMINE|ETHYLAMINE, 2,2'-DITHIOBIS(N,N-DIMETHYL-|BIS(2-DIMETHYLAMINOETHYL)DISULFIDE|NSC101840|UNII-VHF51F4YIW|VHF51F4YIW|BIS[2-(DIMETHYLAMINO)ETHYL] PERSULFIDE|BIS(2-DIMETHYLAMINOETHANE) DISULFIDE|BIS(.BETA.-DIMETHYLAMINOETHYL) DISULFIDE|N,N-TETRAMETHYLCYSTAMINE|(2-{[2-(DIMETHYLAMINO)ETHYL]DISULFANYL}ETHYL)DIMETHYLAMINE|N,N,N',N'-TETRAMETHYLCYSTAMINE|2,2'-DISULFANEDIYLBIS(N,N-DIMETHYLETHANAMINE)|EN300-1723123|BIS(N,N-DIMETHYL-2-AMINOETHYL)DISULFIDE|AKOS028108413|BIS-(2-(N,N-DIMETHYLAMINO)ETHYL)DISULFIDE|BIS(2-DIMETHYLAMINOETHYL) DISULFIDE|ETHANAMINE,2'-DITHIOBIS[N,N-DIMETHYL-|NSC-101840|TETRAMETHYLCYSTAMINE|BIS(2-DIMETHYLAMINOETHYL)DISULPHIDE|BIS(DIMETHYLAMINOETHYL)DISULFIDE|NSC 101840|1072-11-3|NCIOPEN2_004842	-	PUBCHEM	28485	C8H20N2S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	BAEWLQWSDPXZDM-UHFFFAOYSA-N
33168	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	activator	target	Hu H (2022)	36308706	239366	9948	Dimesna	CID 26501|Tavocept|disodium;2-(2-sulfonatoethyldisulfanyl)ethanesulfonate	-	PUBCHEM	26501	C7H20N4O4S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro activator	-
33169	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	activator	target	Hu H (2022)	36308706	239366	9962	pyritinol	Pyrithioxin|Pyrithioxine|Encephabol|Dinerfene|Enerbol|pyritinol|Pyrithioxine (JAN)|Bis(4-hydroxymethyl-5-hydroxy-6-methyl-3-pyridylmethyl)disulfide|4-Pyridinemethanol, 3,3'-[dithiobis(methylene)]bis[5-hydroxy-6-methyl-|Bis[(3-hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl)methyl] Disulfide|Bis(4-hydroxymethyl-5-hydroxy-6-methyl-3-pyridylmethyl) Disulfide|3,3'-[Dithiobis(methylene)]bis[5-hydroxy-6-methyl-4-pyridinemethanol]|5,5'-[Disulfanediylbis(methylene)]bis[4-(hydroxymethyl)-2-methylpyridin-3-ol]|5,5'-[Disulfanediylbis(methylene)]bis[4-(hydroxymethyl)-2-methyl-3-pyridinol]|MFCD00151477|AK5Q5FZH2R	-	CHEMSPIDER	13561	C16H20N2O4S2	small molecule	-	1098-97-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro activator	SIXLXDIJGIWWFU-UHFFFAOYSA-N
33170	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	activator	target	Hu H (2022)	36308706	239366	3175	Oxidized Glutathione Disulfide	-	-	DRUGBANK	DB03310	C20H32N6O12S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro activator	YPZRWBKMTBYPTK-DDHJBXDOSA-N
33176	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Vatansever EC (2021)	33597253	239619	1232	Bepridil	Bepridil|Bepadin	-	DRUGBANK	DB01244	C24H34N2O	small molecule	C08EA02	64706-54-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	UIEATEWHFDRYRU-UHFFFAOYSA-N
33177	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Vatansever EC (2021)	33597253	239619	9907	Ebastine	Ebastine|1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone|4'-tert-Butyl-4-[4-(diphenylmethoxy)piperidino]butyrophenone|4-Diphenylmethoxy-1-[3-(4-tert-butylbenzoyl)propyl]piperidine|4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-[4-(2-methyl-2-propanyl)phenyl]-1-butanone|1-Butanone, 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-|1-(4-tert-butylphenyl)-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one|Ebastin|MFCD00865661	-	CHEMSPIDER	3079	C32H39NO2	small molecule	-	90729-43-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	MJJALKDDGIKVBE-UHFFFAOYSA-N
33178	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Vatansever EC (2021)	33597253	239619	1088	Pimozide	Orap|Halomonth|Pimozida|Pimozide|Opiran|Pimozidum|Neoperidole	orap|pms-pimozide|orap tab 10m	DRUGBANK	DB01100	C28H29F2N3O	small molecule	N05AG02	2062-78-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	YVUQSNJEYSNKRX-UHFFFAOYSA-N
33181	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Nejat R (2021)	34319871	239529	668	Losartan	Losartan|(2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol|2-N-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole|DuP 89	jamp-losartan hctz|losartan/hc	DRUGBANK	DB00678	C22H23ClN6O	small molecule	C09CA01|C09DA01|C09DB06	114798-26-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	PSIFNNKUMBGKDQ-UHFFFAOYSA-N
33183	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Pitsillou E (2020)	33364229	239789	10247	hypericin	Hypericin|hypericum red|VIMRxyn|1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione|Phenanthro[1,10,9,8-opqra]perylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-|Cyclo werrol|1917913|MFCD00016683|7V2F1075HD|4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone|CYCLOSAN	-	CHEMSPIDER	4444511	C30H16O8	small molecule	-	548-04-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	BTXNYTINYBABQR-UHFFFAOYSA-N
33184	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Pitsillou E (2020)	33364229	239789	1633	Rutin	rutoside|quercetin-3-rutinoside|Phytomelin|sophorin|2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-4-Oxo-4h-Chromen-3-Yl 6-O-(6-Deoxy-Alpha-L-Mannopyranosyl)-Beta-D-Glucopyranoside	-	DRUGBANK	DB01698	C27H30O16	small molecule	C05CA01|C05CA51	153-18-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	IKGXIBQEEMLURG-BKUODXTLSA-N
33185	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Pitsillou E (2020)	33364229	239789	10183	cyanidin-3-O-glucoside	Chrysanthemin|asterin|Cyanidin 3-glucoside|Kuromanin|Cyanidin Chloride 3-Glucoside|KUROMANIN CHLORIDE|Cyanidin 3-O-glucoside chloride|2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-chromeniumyl beta-D-glucopyranoside chloride|2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-chromeniumyl-beta-D-glucopyranosidechlorid|beta-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-1-benzopyrylium-3-yl, chloride (1:1)|2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}chromenium chloride|2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}chromeniumchlorid|2-(3,4-Dihydroxyphenyl)-5,7-dihydroxychromenium-3-yl beta-D-glucopyranoside chloride|MFCD27665410|CYANIDIN 3-GLUCOSIDE CHLORIDE|8X15R84UEM|Glucocyanidin chloride|Cyanidin 3-O-glucoside (chloride)|2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1??-chromen-1-ylium chloride	-	CHEMSPIDER	170681	C21H21ClO11	small molecule	-	47705-70-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	YTMNONATNXDQJF-UBNZBFALSA-N
33186	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Hamed MIA (2021)	35493159	240073	602	Bisoprolol	(+-)-1-((alpha-(2-Isopropoxyethoxy)-P-tolyl)oxy)-3-(isopropylamino)-2-propanol|Bisoprololum|(RS)-1-(4-(2-isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol|Bisoprolol	monocor   -(5mg)|bisoprolol fu	DRUGBANK	DB00612	C18H31NO4	small molecule	C07BB07|C09BX02|C07FB07|C07AB07|C07AB57	66722-44-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	VHYCDWMUTMEGQY-UHFFFAOYSA-N
33187	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Hamed MIA (2021)	35493159	240073	4661	Nebivolol	alpha,alpha'-(iminodimethylene)bis-(6-fluoro-2-chromanmethanol)|Nebivololum|Narbivolol|1,1'-[Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol|alpha,alpha'-(iminobismethylene)bis-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)|1,1'-Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2,2'-iminodiethanol	byvalson|nebivolol|bystolic	DRUGBANK	DB04861	C22H25F2NO4	small molecule	C07FB12|C07BB12|C07AB12	118457-14-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	KOHIRBRYDXPAMZ-UHFFFAOYSA-N
33191	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Costanzi E (2021)	34769210	240265	9567	Z-Leu-leu-leu-al	CBZ-LEU-LEU-LEU-AL|Z-LLL|BRD-0970|BENZYLOXYCARBONYL-LEU-LEU-LEUCINAL|COMPOUND 5B [PMID: 16686537]|DTXSID3042639|KBIOSS_000030|EX-A1500|MFCD00674886|KBIO3_000059|CARBOBENZOXYL-LEUCINYL-LEUCINYL-LEUCINAL-H|NCGC00161679-02|X7579|MG-132 [Z-LEU-LEU-LEU-CHO]|CCG-207860|Z-LEU-LEU-LEUCINAL|Q3272916|BRD0970|MG-132-1|AOB4946|BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE|NCGC00161679-01|UNM000011053701|L-LEUCINAMIDE, N-((PHENYLMETHOXY)CARBONYL)-L-LEUCYL-N-(1-FORMYL-3-METHYLBUTYL)-, (S)-|SR-01000864598-1|CBZ-L-LEU-L-LEU-L-LEU-H|CCG-208036|N-BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-LEUCINAL|LLL CPD|Z-LEU-LEU-LEU-AL, >=90% (HPLC)|Z-LLLAL|BENZYLOXYCARBONYL-LEU-LEU-LEU-ALDEHYDE|MG 132|CS-0471|BENZYL N-[(1S)-3-METHYL-1-[[(1S)-3-METHYL-1-[[(2S)-4-METHYL-1-OXO-PENTAN-2-YL]CARBAMOYL]BUTYL]CARBAMOYL]BUTYL]CARBAMATE|SC-93546|133407-82-6|SW219780-1|KBIO3_000060|ZX-AFC000065|MG132/MG-132/|S2619|Z-LEU-LEU-LEU-AL|PHENYLMETHYL N-[(2S)-4-METHYL-1-[[(2S)-4-METHYL-1-[[(2S)-4-METHYL-1-OXOPENTAN-2-YL]AMINO]-1-OXOPENTAN-2-YL]AMINO]-1-OXOPENTAN-2-YL]CARBAMATE|CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-LEUCINAL|BIC3742|IDI1_033780|MG-132|BRD-K60230970-001-06-8|CARBOBENZOXY-LEUCYL-LEUCYL-LEUCINAL|Z-LEU-LEU-LEU-ALDEHYDE|HMS3402B12|CBZ-L-LEU-L-LEU-L-LEU-CHO|ABP000958|BRD-K60230970-001-08-4|(S)-N-((PHENYLMETHOXY)CARBONYL)-L-LEUCYL-N-(1-FORMYL-3-METHYLBUTYL)-L-LEUCINAMIDE|BIO2_000030|Z-L-LEU-L-LEU-L-LEU-H|(S)-4-METHYL-2-(3-PHENYL-PROPIONYLAMINO)-PENTANOIC ACID [(S)-1-((S)-1-FORMYL-3-METHYL-BUTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE|ACN-047884|Z-LLL-ALDEHYDE|CBZ-LEU-LEU-LEUCINAL|N-[(BENZYLOXY)CARBONYL]-L-LEUCYL-N-[(1S)-1-FORMYL-3-METHYLBUTYL]-L-LEUCINAMIDE|NCGC00161679-03|BENZYL(S)-4-METHYL-1-((S)-4-METHYL-1-((S)-4-METHYL-1-OXOPENTAN-2-YLAMINO)-1-OXOPENTAN-2-YLAMINO)-1-OXOPENTAN-2-YLCARBAMATE|AS-55854|HY-13259|W-5117|L-LEUCINAMIDE, N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N1-[(1S)-1-FORMYL-3-METHYLBUTYL]-|BRD-K60230970-001-05-0|SB19111|MLS006011220|N-[(BENZYLOXY)CARBONYL]-L-LEUCYL-N-[(2S)-4-METHYL-1-OXOPENTAN-2-YL]-L-LEUCINAMIDE|CARBOBENZOXY-LEU-LEU-LEUCINAL|{1-[1-(1-FORMYL-3-METHYL-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL]-3-METHYL-BUTYL}-CARBAMIC ACID BENZYL ESTER|(R)-MG132|HMS1361B12|BSPBIO_001310|CC-245|HMS1989B12|C26H41N3O5|BIO2_000510|Z-LLL-H|MG132|PI-102|(S)-MG132|BENZYL N-[(1S)-1-[[(1S)-1-[[(1S)-1-FORMYL-3-METHYL-BUTYL]CARBAMOYL]-3-METHYL-BUTYL]CARBAMOYL]-3-METHYL-BUTYL]CARBAMATE|UNII-RF1P63GW3K|BENZYL ((S)-4-METHYL-1-(((S)-4-METHYL-1-(((S)-4-METHYL-1-OXOPENTAN-2-YL)AMINO)-1-OXOPENTAN-2-YL)AMINO)-1-OXOPENTAN-2-YL)CARBAMATE|SMR002530629|{(S)-1-[(S)-1-((S)-1-FORMYL-3-METHYL-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL]-3-METHYL-BUTYL}-CARBAMIC ACID BENZYL ESTER|KS-00000XP9|QCR-183|BRD-K60230970-001-04-3|1211877-36-9|NCGC00161679-04|BRD-K60230970-001-07-6|KBIO2_005166|ZINC13476439|GTPL8616|BCBCMAP01_000028|HMS1791B12|N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N-[(1S)-1-FORMYL-3-METHYLBUTYL]-L-LEUCINAMIDE|KBIO2_002598|L-LEUCINAMIDE, N-((PHENYLMETHOXY)CARBONYL)-L-LEUCYL-N-((1S)-1-FORMYL-3-METHYLBUTYL)-|Z-LLL-CHO|AKOS027420457|BENZYLOXYCARBONYL-LEUCYL-LEUCYL-LEUCINAL|ZLLL-CHO|Z-LEU-LEU-LEU-H|KBIO2_000030|N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-N-(1-FORMYL-3-METHYLBUTYL)-(S)-L-LEUCINAMIDE|KBIOGR_000030|BENZYL (S)-4-METHYL-1-((S)-4-METHYL-1-((S)-4-METHYL-1-OXOPENTAN-2-YLAMINO)-1-OXOPENTAN-2-YLAMINO)-1-OXOPENTAN-2-YLCARBAMATE|CTK8F0239|CBZ-LEU-LEU-LEU-H|AB0033810|{1-[(S)-(S)-1-((S)-1-FORMYL-3-METHYL-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL]-3-METHYL-BUTYL}-CARBAMIC ACID BENZYL ESTER|RF1P63GW3K|BRD-K60230970-001-10-0|ZLLLAL|BDBM50069985	-	PUBCHEM	462382	C26H41N3O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	TZYWCYJVHRLUCT-VABKMULXSA-N
33192	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Lee S (2021)	34868052	240341	10285	Casirivimab	-	-	PUBCHEM	442064779	-	monoclonal antibody	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike binding (experimental), antiviral activity against SARS-CoV-2 WT, Alpha, Beta and Gamma variants	-
33193	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Lee S (2021)	34868052	240341	10286	Imdevimab	-	-	PUBCHEM	442064836	-	monoclonal antibody	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike binding (experimental), antiviral activity against SARS-CoV-2 WT, Alpha, Beta and Gamma variants	-
33194	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Kiyan Y (2022)	36207386	240352	10173	CaD/Calcium dobesilate	Calcium Doxybensylate|Calcium bis(2,5-dihydroxybenzenesulfonate)|MFCD00867249|5921X1560Q|205E|Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt (2:1)|2,5-Dihydroxybenzenesulfonic acid calcium salt|calcium 2,5-dihydroxybenzenesulfonate|Calcium dobesilate|Dobesilate calcium	-	CHEMSPIDER	27837	C12H10CaO10S2	small molecule	-	20123-80-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-heparan sulfate interaction inhibitor, Spike binding undetermined	QGNBTYAQAPLTMX-UHFFFAOYSA-L
33195	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Zhou L (2022)	36053674	240134	10287	HLX70	-	-	PUBCHEM	468403880	-	monoclonal antibody	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : WT, Delta, and Omicron variant Spike binding (experimental) (PMID 33264452 and 36053674), antiviral activity against SARS-CoV-2 WT, Alpha (B.1.1.7) and Epsilon (B.1.429) variants (PMID 34285198 and 33262452)	-
33196	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Wnorowska S (2022)	35846513	240057	10269	carlina oxide	Carlina oxide|furan, 2-(3-phenyl-1-propynyl)-|2-(3-Phenyl-1-propyn-1-yl)furan|Furan, 2-(3-phenyl-1-propyn-1-yl)-	-	CHEMSPIDER	144325	C13H10O	small molecule	-	502-22-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (computational)	ICRHFCVRNWSKQH-UHFFFAOYSA-N
33200	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Kiew LV (2021)	33857754	240463	10270	Ramiprilat	Ramiprilat|6N5U4QFC3G|(2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-Carboxy-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid	-	CHEMSPIDER	4576531	C21H28N2O5	small molecule	-	87269-97-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, ACE2 binding (experimental)	KEDYTOTWMPBSLG-HILJTLORSA-N
33201	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Kiew LV (2021)	33857754	240463	10184	Perindoprilat	2UV6ZNQ92K|(2S-(1(R*(R*)),2a,3ab,7ab))-Octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-1H-indole-2-carboxylic Acid|Perindoprilat|S-9780|(2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-Carboxybutyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid	-	CHEMSPIDER	65017	C17H28N2O5	small molecule	-	95153-31-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, ACE2 binding (experimental)	ODAIHABQVKJNIY-PEDHHIEDSA-N
33202	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Kiew LV (2021)	33857754	240463	171	Ramipril	Ramiprilum|(2S-(1(R*(r*)),2alpha,3abeta,6abeta))-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid|Ramipril|Altace (tn)|Tritace	ava-ramipril|altace hct|ramipr	DRUGBANK	DB00178	C23H32N2O5	small molecule	C09AA05|C09BA05|C09BB05|C09BB07|C10BX04|C10BX06	87333-19-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, ACE2 binding (experimental)	HDACQVRGBOVJII-JBDAPHQKSA-N
33203	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Ni X (2021)	33850605	240527	10228	GS-441524	GS-441524|(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furancarbonitrile|(2R,3R,4S,5R)-2-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile	-	CHEMSPIDER	28499294	C12H13N5O4	small molecule	-	1191237-69-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Nsp3 binding (experimental) (PMID 33850605), antiviral activity (PMID 33523654)	BRDWIEOJOWJCLU-LTGWCKQJSA-N
33204	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Kim YS (2021)	34445310	240533	10188	geraniin	Geraniin|benzoic acid, 3,4,5-trihydroxy-, (3R,4aR,11R,11aS,25R,25aR,29S)-2,3,4,4a,9,11a,13,22,24,25,25a,27-dodecahydro-3,4,4,6,7,15,16,17,18,19,20-undecahydroxy-2,9,13,22,27-pentaoxo-3,5-epoxy-25,11-(epoxymethano)-11H-dibenzo[h,j]dibenzo[7,8:9,10][1,5]dioxacycloundecino[3,2-b][1,6]dioxacyclododecin-29-yl ester|(1R,7R,8S,26R,28S,29R,38R)-1,13,14,15,18,19,20,34,35,39,39-Undecahydroxy-2,5,10,23,31-pentaoxo-6,9,24,27,30,40-hexaoxaoctacyclo[34.3.1.0~4,38~.0~7,26~.0~8,29~.0~11,16~.0~17,22~.0~32,37~]tetraconta-3,11,13,15,17,19,21,32,34,36-decaen-28-yl 3,4,5-trihydroxybenzoate	-	CHEMSPIDER	10270376	C41H28O27	small molecule	-	60976-49-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding and ACE2 binding (experimental)	JQQBXPCJFAKSPG-SVYIMCMUSA-N
33205	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Balkrishna A (2021)	33737804	240540	10261	withanone	withanone|WITHANONE(SH)|GY036XA633|(22R)-6alpha,7alpha-Epoxy-5,17,22-trihydroxy-1-oxo-5alpha-ergosta-2,24-dien-26-oic acid delta-lactone|MFCD09264639|Ergosta-2,24-diene-1,26-dione, 6,7:22,26-diepoxy-5,17-dihydroxy-, (5alpha,6alpha,7alpha,22R)-|(5alpha,6alpha,7alpha,22R)-5,17-Dihydroxy-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione	-	CHEMSPIDER	10294995	C28H38O6	small molecule	-	27570-38-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike and ACE2 binding (computational)	FAZIYUIDUNHZRG-PCTWTJKKSA-N
33206	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Chakraborty S (2022)	36098617	246221	10261	withanone	withanone|WITHANONE(SH)|GY036XA633|(22R)-6alpha,7alpha-Epoxy-5,17,22-trihydroxy-1-oxo-5alpha-ergosta-2,24-dien-26-oic acid delta-lactone|MFCD09264639|Ergosta-2,24-diene-1,26-dione, 6,7:22,26-diepoxy-5,17-dihydroxy-, (5alpha,6alpha,7alpha,22R)-|(5alpha,6alpha,7alpha,22R)-5,17-Dihydroxy-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione	-	CHEMSPIDER	10294995	C28H38O6	small molecule	-	27570-38-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	FAZIYUIDUNHZRG-PCTWTJKKSA-N
33207	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Chakraborty S (2022)	36098617	246221	10186	withaferin A	4b,27-Dihydroxy-1-oxo-5b,6b-epoxywitha-2,24-dienolide|5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid d-Lactone|(4b,5b,6b,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone|(4beta,5beta,6beta,22R)-4,27-Dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione|Ergosta-2,24-diene-1,26-dione, 5,6:22,26-diepoxy-4,27-dihydroxy-, (4beta,5beta,6beta,22R)-|MFCD10687098|Withaferine|5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide|Withaferin A|Withaferine A	-	CHEMSPIDER	233064	C28H38O6	small molecule	-	5119-48-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	DBRXOUCRJQVYJQ-CKNDUULBSA-N
33208	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Shi TH (2020)	32977949	246222	8600	andrographolide	[1R-[1a[E(S*)],4ab,5a,6a,8aa]]-3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone|3a,14,15,18-Tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic Acid g-Lactone|Chuanxinlian|Kalmegh|(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone|2(3H)-Furanone, 3-[2-[(1R,4aS,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E)-|(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylendecahydro-1-naphthalenyl]ethyliden}dihydro-2(3H)-furanon|(3E)-4-hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one|(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one	-	CHEMSPIDER	16735664	C20H30O5	small molecule	-	5508-58-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor (Antiviral activity, PMID: 33844528)	BOJKULTULYSRAS-FNTFRYDESA-N
33209	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Shi TH (2020)	32977949	246222	8600	andrographolide	[1R-[1a[E(S*)],4ab,5a,6a,8aa]]-3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone|3a,14,15,18-Tetrahydroxy-5b,9bH,10a-labda-8(20),12-dien-16-oic Acid g-Lactone|Chuanxinlian|Kalmegh|(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone|2(3H)-Furanone, 3-[2-[(1R,4aS,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E)-|(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylendecahydro-1-naphthalenyl]ethyliden}dihydro-2(3H)-furanon|(3E)-4-hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one|(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one	-	CHEMSPIDER	16735664	C20H30O5	small molecule	-	5508-58-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	BOJKULTULYSRAS-FNTFRYDESA-N
33210	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Binette V (2021)	34223589	240577	10181	corilagin	corilagin|Benzoic acid, 3,4,5-trihydroxy-, (8R,10S,11R,12S,19R)-5,7,8,11,12,14-hexahydro-1,2,3,11,16,17,18,19-octahydroxy-5,14-dioxo-8,12-methano-10H-dibenzo[j,l][1,4,8]trioxacyclotetradecin-10-yl ester|(1S,19R,21S,22R,23R)-6,7,8,11,12,13,22,23-Octahydroxy-3,16-dioxo-2,17,20-trioxatetracyclo[17.3.1.0~4,9~.0~10,15~]tricosa-4,6,8,10,12,14-hexaen-21-yl 3,4,5-trihydroxybenzoate|MFCD00238565	-	CHEMSPIDER	66248	C27H22O18	small molecule	-	2088321-44-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (experimental)	TUSDEZXZIZRFGC-XIGLUPEJSA-N
33211	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Binette V (2021)	34223589	240577	10288	1,3,6-tri-O-galloyl-beta-D-glucose	BETA-D-GLUCOPYRANOSE 1,3,6-TRIGALLATE|NSC 69861|(2S,3R,4S,5R,6R)-3,5-DIHYDROXY-6-(((3,4,5-TRIHYDROXYBENZOYL)OXY)METHYL)TETRAHYDRO-2H-PYRAN-2,4-DIYL BIS(3,4,5-TRIHYDROXYBENZOATE)|1,3,6-TRI-O-GALLOYLGLUCOSE|1,3,6-TRI-O-GALLOYL--D-GLUCOSE|ACON1_002062|1,3,6-TRI-O-GALLOYL-B-D-GLUCOSE|1,3,6-TRI-O-GALLOYL-.BETA.-D-GLUCOPYRANOSE|BETA-D-GLUCOPYRANOSE-1,3,6-TRIS(3,4,5-TRIHYDROXYBENZOATE|E87143|1,3,6-TRI-O-GALLOYL-BETA-D-GLUCOSE|[(2R,3R,4S,5R,6S)-3,5-DIHYDROXY-4,6-BIS[(3,4,5-TRIHYDROXYBENZOYL)OXY]TETRAHYDROPYRAN-2-YL]METHYL 3,4,5-TRIHYDROXYBENZOATE|1,3,6-TRIGALLOYL GLUCOSE|MS-30889|1,3,6-TRI-O-GALLOYL-B-D-GLUCOPYRANOSE|NCGC00179867-01|1,3,6-TRI-O-GALLOYL- BETA -D-GLUCOSE|BETA-D-GLUCOPYRANOSE, 1,3,6-TRIS(3,4,5-TRIHYDROXYBENZOATE)|CS-0032136|DTXSID3041667|NSC-69861|GLUCOPYRANOSE, 1,3,6-TRIGALLATE, .BETA.-D-|1,3,6-TRI-O-GALLOYL GLUCOSE|GALLOTANNINS|.BETA.-D-GLUCOPYRANOSE 1,3,6-TRIGALLATE|O8718334XJ|W-201661|AKOS015965331|.TANNIN|NCGC00179867-02|GLUCOPYRANOSE, 1,3,6-TRIGALLATE, BETA-D-|18483-17-5|HY-N6006|1,3,6-TRIS(3,4,5-TRIHYDROXYBENZOATE)BETA-D-GLUCOPYRANOSE|C17458|.BETA.-D-GLUCOPYRANOSE, 1,3,6-TRIS(3,4,5-TRIHYDROXYBENZOATE)|Q13423012|1,3,6-TRI-O-GALLOYL-BETA-D-GLUCOPYRANOSE|TANNIC ACID (CORILAGIN)|AC-20241|MEGXP0_001387|1,3,6-TRIGALLOYLGLUCOSE, >=95% (LC/MS-ELSD)|1,3,6-TRI-O-GALLOYL-BETA-D-GLUCOSE, ANALYTICAL STANDARD|J303.464J|UNII-O8718334XJ	-	PUBCHEM	452707	C27H24O18	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (experimental)	RNKMOGIPOMVCHO-SJMVAQJGSA-N
33215	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Henss L (2021)	33830908	241214	9892	Epigallocatechin gallate	EGCG|Epigallocatechin 3-gallate|Epigallocatechin gallate|(-)-Epigallocatechin gallate|(-)-EGCG|(-)-Epigallocatechin-3-o-gallate|(-)-epigallocatechin 3-gallate|(2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate|Benzoic acid, 3,4,5-trihydroxy-, (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester|(-)-Epigallocatechin 3-O-gallate|3,4,5-Trihydroxybenzoic acid (2R-cis)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester|(-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate|KB5200000|MFCD00075940|(-)-cis-3,3',4',5,5',7-Hexahydroxy-flavane-3-gallate	-	CHEMSPIDER	58575	C22H18O11	small molecule	-	989-51-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor; antiviral activity against SARS-CoV-2 WT, MUC-IMB-1, and Delta variants	WMBWREPUVVBILR-WIYYLYMNSA-N
33216	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Ohgitani E (2021)	34208050	240738	10166	TSA/Theasinensin A	Benzoic acid, 3,4,5-trihydroxy-, (4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-diyl)bis[(2R,3R)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl] ester|Theasinensin D|theasinensin A|(4,4',5,5',6,6'-Hexahydroxy-2,2'-biphenyldiyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)|(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)bis[(2R,3R)-5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl] bis(3,4,5-trihydroxybenzoate)	-	CHEMSPIDER	390965	C44H34O22	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, antiviral activity against SARS-CoV-2 JPN/TY/WK-521	YUULFXAQUWEYNP-GXAWFILRSA-N
33217	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Ohgitani E (2021)	34208050	240738	10221	"TFDG/theaflavin 3,3'-di-O-gallate"	(3,4,5-Trihydroxy-6-oxo-6H-benzo[7]annulene-1,8-diyl)bis(5,7-dihydroxy-3,4-dihydro-2H-chromene-2,3-diyl) bis(3,4,5-trihydroxybenzoate)|Benzoic acid, 3,4,5-trihydroxy-, (3,4,5-trihydroxy-6-oxo-6H-benzocycloheptene-1,8-diyl)bis(3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-2,3-diyl) ester	-	CHEMSPIDER	2825757	C43H32O20	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, antiviral activity against SARS-CoV-2 JPN/TY/WK-521	ZEASWHWETFMWCV-UHFFFAOYSA-N
33221	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	7943	Netoglitazone	MCC 555|PGX-510|RWJ-241947	-	DRUGBANK	DB09199	C21H16FNO3S	small molecule	-	161600-01-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	PKWDZWYVIHVNKS-UHFFFAOYSA-N
33222	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	10289	Bictegravir	BICTEGRAVIR [USAN:INN]|A902376|GTPL11575|CS-0014685|BICTEGRAVIR (USAN/INN)|BICTEGRAVIR [USAN]|AKOS032954062|S5911|1611493-60-7|BICTEGRAVIR [WHO-DD]|UNII-8GB79LOJ07|BCP25703|BICTEGRAVIR [MI]|BICTEGRAVIR [INN]|EX-A3161|(2R,5S,13AR)-8-HYDROXY-7,9-DIOXO-N-(2,4,6-TRIFLUOROBENZYL)-2,3,4,5,7,9,13,13A-OCTAHYDRO-2,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[2, 1-B][1,3]OXAZEPINE-10-CARBOXAMIDE|DTXSID701027937|GS-9883|SOLUWJRYJLAZCX-LYOVBCGYSA-N|BICTEGRAVIRUM|US9663528, 42|(1S,11R,13R)-5-HYDROXY-3,6-DIOXO-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-12-OXA-2,9-DIAZATETRACYCLO[11.2.1.0(2),(1)(1).0?,?]HEXADECA-4,7-DIENE-7-CARBOXAMIDE|DB11799|D10909|DT-0020|2,5-METHANOPYRIDO(1',2':4,5)PYRAZINO(2,1-B)(1,3)OXAZEPINE-10-CARBOXAMIDE, 2,3,4,5,7,9,13,13A-OCTAHYDRO-8-HYDROXY-7,9-DIOXO-N-((2,4,6-TRIFLUOROPHENYL)METHYL)-, (2R,5S,13AR)-|8GB79LOJ07|BICTEGRAVIR|(1S,11R,13R)-5-HYDROXY-3,6-DIOXO-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-12-OXA-2,9-DIAZATETRACYCLO[11.2.1.0^{2,11}.0^{4,9}]HEXADECA-4,7-DIENE-7-CARBOXAMIDE|GS 9883|HY-17605|EN300-22793610|(1S,11R,13R)-5-HYDROXY-3,6-DIOXO-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-12-OXA-2,9-DIAZATETRACYCLO[11.2.1.02,11.04,9]HEXADECA-4,7-DIENE-7-CARBOXAMIDE|AC-30658|GS-9883-01|AMY12383|GS9883|GS-9883; GS 9883; GS9883; GS-9883-01|(2R,5S,13AR)-8-HYDROXY-7,9-DIOXO-N-(2,4,6-TRIFLUOROBENZYL)-2,3,4,5,7,9,13,13A-OCTAHYDRO-2,5-METHANOPYRIDO[1',2':4,5]PYRAZINO[2,1-B][1,3]OXAZEPINE-10-CARBOXAMIDE|N16998|Q27270406	-	PUBCHEM	90311989	C21H18F3N3O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	SOLUWJRYJLAZCX-LYOVBCGYSA-N
33223	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	10167	ANA-12	N2-(2-{[(2-oxoazepan-3-yl)amino]carbonyl}phenyl)benzo[b]thiophene-2-carboxamide|Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-|N-{2-[(2-Oxo-3-azepanyl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide|ANA-12|N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide|N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide|MFCD00117444|ANA 12|N-{2-[(2-OXO-3-AZEPANYL)CARBAMOYL]PHENYL}-1-BENZOTHIOPHENE-2-CARB OXAMIDE|BCP16021|N-[2-[[(HEXAHYDRO-2-OXO-1H-AZEPIN-3-YL)AMINO]CARBONYL]PHENYL]BENZO[B]THIOPHENE-2-CARBOXAMIDE|HY-12497|N-[2-[[(HEXAHYDRO-2-OXO-1H-AZEPIN-3-YL)AMINO]CARBONYL]PHENYL]-BENZO[B]THIOPHENE-2-CARBOXAMIDE|BENZO(B)THIOPHENE-2-CARBOXAMIDE, N-(2-(((HEXAHYDRO-2-OXO-1H-AZEPIN-3-YL)AMINO)CARBONYL)PHENYL)-|S7745|CCG-222404|UNII-54S4JPT8JX|NCGC00379202-06|MAYBRIDGE1_001394|HMS3886N17|N-(2-((2-OXOAZEPAN-3-YL)CARBAMOYL)PHENYL)BENZO[B]THIOPHENE-2-CARBOXAMIDE|219766-25-3|A878840|OPREA1_341312|EX-A815|HMS545H08|54S4JPT8JX|FT-0700267|CS-3616|J-690263|N-{2-[(2-OXOAZEPAN-3-YL)CARBAMOYL]PHENYL}-1-BENZOTHIOPHENE-2-CARBOXAMIDE|DTXSID501045818|ANA-12, >=98% (HPLC)|N-(2-(2-OXOAZEPAN-3-YLCARBAMOYL)PHENYL)BENZO[B]THIOPHENE-2-CARBOXAMIDE|N-[2-[(2-OXOAZEPAN-3-YL)CARBAMOYL]PHENYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE|AS-16798|ANA-12|AC-32995|N-(2-(((HEXAHYDRO-2-OXO-1H-AZEPIN-3-YL)AMINO)CARBONYL)PHENYL)BENZO(B)THIOPHENE-2-CARBOXAMIDE|MFCD00117444|AKOS024458344|ANA12|NCGC00379202-10	-	CHEMSPIDER	2078460	C22H21N3O3S	small molecule	-	219766-25-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	TUSCYCAIGRVBMD-UHFFFAOYSA-N
33224	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	10291	Bisdemethoxycurcumin	BISDEMETHOXYCUCURMIN|1,7-BIS(4-HYDROXYPHENYL)HEPTA-1,6-DIENE-3,5-DIONE|1,7-BIS(4-HYDROXYPHENYL)-1,6-HEPTADIENE-3,5-DIONE|(E,E)-BISDEMETHOXYCURCUMIN|(1E,6E)-1,7-BIS(4-HYDROXYPHENYL)HEPTA-1,6-DIENE-3,5-DIONE|BISDESMETHOXYCURCUMIN|Q-100322|AC-34720|1,6-HEPTADIENE-3,5-DIONE, 1,7-BIS(4-HYDROXYPHENYL)-, (E,E)-|E-100(III)|DIDEMETHOXYCURCUMIN|(1E,4Z,6E)-5-HYDROXY-1,7-BIS-(4-HYDROXY-PHENYL)-HEPTA-1,4,6-TRIEN-3-ONE|A875406|BHCMT|DIDE METHOXYCURCU MIN|DI-P-COUMAROYLMETHANE|S3938|INS-100(III)|BIS(P-HYDROXYCINNAMOYL)METHANE|24939-16-0|NSC687839|22608-12-4|AKOS015902102|CURCUMIN LLL|(1E,6E)-1,7-BIS(4-HYDROXYPHENYL)-HEPTA-1,6-DIENE-3,5-DIONE|AC-24239|UNII-2EFO1BP34R|INS NO.100(III)|P,P'-DIHYDROXYDICINNAMOYLMETHANE|BIS(4-HYDROXYCINNAMOYL)METHANE|HY-N0007A|CCG-208635|1,7-BIS(4-HYDROXYPHENYL)-1,6-HEPTADIENE-3,5-DIONE(E,E)|CURCUMIN III|DTXSID00872663|BISDEMETHOXY CURCUMIN|B3347|CCG-207959|BISDEMETHOXYCURCUMIN|CURCUMIN III;DIDEMETHOXYCURCUMIN|1,7-BIS(4-HYDROXYPHENYL)-3-HYDROXY-1,3,6-HEPTATRIEN-5-ONE|ZAA93916|1,7-BIS-(4-HYDROXYPHENYL)-HEPTA-1,6-DIENE-3,5-DIONE|BISDESMETHOXYCURCUMIN [USP-RS]|CS-0018287|BIS-DEMETHOXYCURCUMIN|(1E,6E)-1,7-BIS-(4-HYDROXY-PHENYL)-HEPTA-1,6-DIENE-3,5-DIONE|Q4917168|BISDEMETHOXYCURCUMIN, ANALYTICAL STANDARD|33171-05-0|5-HYDROXY-1,7-BIS-(4-HYDROXY-PHENYL)-HEPTA-1,4,6-TRIEN-3-ONE|BDMC;(E,E)-CURCUMIN III|CURCUMINOID A|AS-68737|MFCD03419284|2EFO1BP34R|1,6-HEPTADIENE-3,5-DIONE, 1,7-BIS(4-HYDROXYPHENYL)-|ADAMANTAN-1-YL-ACETICACIDHYDRAZIDE|BRD-K37445107-001-01-9|NSC-687839|BISDEMETHOXYCURCUMIN, >=98% (HPLC), SOLID|CID_5324473|C19H16O4|AS-57295|1,6-HEPTADIENE-3,5-DIONE, 1,7-BIS(4-HYDROXYPHENYL)-, (1E,6E)-|(1E,6E)-1,7-BIS(4-HYDROXYPHENYL)-1,6-HEPTADIENE-3,5-DIONE|BIS-DEMETHOXYCURCUMIN [INCI]	-	PUBCHEM	5315472	C19H16O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	PREBVFJICNPEKM-YDWXAUTNSA-N
33225	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	10292	Galloflavin Potassium	POTASSIUM;2,9,10-TRIHYDROXY-6,8-DIOXOPYRANO[3,2-C]ISOCHROMEN-3-OLATE|GALLOFLAVINPOTASSIUMSALT|POTASSIUM 8,9,10-TRIHYDROXY-2,6-DIOXO-2,6-DIHYDROPYRANO[3,2-C]ISOCHROMEN-3-OLATE|AKOS024458351|3,8,9,10-TETRAHYDROXY-PYRANO[3,2-C][2]BENZOPYRAN-2,6-DIONE POTASSIUM SALT|1780260-20-9|GALLOFLAVIN POTASSIUM|3,8,9,10-TETRAHYDROXYPYRANO[3,2-C][2]BENZOPYRAN-2,6-DIONE POTASSIUM SALT	-	PUBCHEM	136645905	C12H5KO8	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	ZXTYKQDMPYEPEX-UHFFFAOYSA-M
33226	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	10293	Icilin	HY-11062|ICILIN(AG 3-5)|'3-(2-HYDROXYPHENYL)-6-(3-NITROPHENYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE'|NCGC00015571-07|ICILLIN|ICILIN|AG 3-5 CPD|BRN 0700310|MFCD01689072|AS-35111|TOX21_500426|CS70PZQ4QJ|HMS2769B07|AG 3-5|SDCCGSBI-0050411.P002|BI164563|1-(2-HYDROXYPHENYL)-4-(3-NITROPHENYL)-1,2,3,6-TETRAHYDROPYRIMIDIN-2-ONE|NCGC00025205-02|GTPL2429|AG-3-5|C20171|HMS3412H21|NCGC00025205-01|BRD-K48869804-001-04-7|AC-35209|ICILIN- BIO-X|SR-01000075377-1|3,4-DIHYDRO-3-(2-HYDROXYPHENYL)-6-(3-NITROPHENYL)-(1H)-PYRIMIDIN-2-ONE|HMS3676H21|SR-01000075377-4|5-24-03-00255 (BEILSTEIN HANDBOOK REFERENCE)|Q5986473|NCGC00015571-01|LOPAC-I-9532|LP00426|1-(2-HYDROXYPHENYL)-4-(3-NITROPHENYL)-3,6-DIHYDROPYRIMIDIN-2-ONE|CCG-221730|NCGC00015571-05|3-(2-HYDROXYPHENYL)-6-(3-NITROPHENYL)-1,2,3,4-TETRAHYDROPYRIMIDIN-2-ONE|AG 3-5; AG3-5; AG-3-5|NCGC00015571-02|NCGC00025205-03|3-(2-HYDROXYPHENYL)-6-(3-NITROPHENYL)-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE|C16H13N3O4|UNII-CS70PZQ4QJ|NCGC00015571-15|NCGC00015571-03|I 9532|DTXSID70190442|HMS3261E14|CCG-204518|SMR000299977|SR-01000075377-2|ICILIN, >=97% (HPLC), SOLID|2(1H)-PYRIMIDINONE, 3,6-DIHYDRO-1-(2-HYDROXYPHENYL)-4-(3-NITROPHENYL)-|A903163|MLS000693445|CS-1922|EU-0100426|MLS002153471|36945-98-9|ICILIN [MI]|AKOS000370368|BCP27818|TOCRIS-1531|SR-01000075377|NCGC00261111-01|1-(2-HYDROXYPHENYL)-4-(3-NITROPHENYL)-1,2,3,6-TETRAHYDROPYRIMIDINE-2-ONE|LOPAC0_000426|EX-A279|1-(2'-HYDROXYPHENYL)-4-(3''-NITROPHENYL)-1,2,3,6-TETRAHYDROPYRIMIDINE-2-ONE|SMP2_000128|3-(2-HYDROXYPHENYL)-6-(3-NITROPHENYL)-3,4-DIHYDRO-2(1H)-PYRIMIDINONE|AG-3-5; 1-(2-HYDROXYPHENYL)-4-(3-NITROPHENYL)-1,2,3,6-TETRAHYDROPYRIMIDIN-2-ONE|SR-01000075377-9|HB1153|3,6-DIHYDRO-1-(2-HYDROXYPHENYL)-4-(3-NITROPHENYL)-2(1H)-PYRIMIDINONE|HMS3648E15|HMS3268C05|FT-0700300|3-(2-HYDROXYPHENYL)-6-(3-NITROPHENYL)-1,4-DIHYDROPYRIMIDIN-2-ONE|NCGC00015571-04|RCEFMOGVOYEGJN-UHFFFAOYSA-N	-	PUBCHEM	161930	C16H13N3O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	RCEFMOGVOYEGJN-UHFFFAOYSA-N
33227	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	956	Telmisartan	4'-((1,4'-Dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid|4'-[(1,7'-Dimethyl-2'-propyl-1H,3'h-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid|Telmisartan|4'-[(1,4'-Dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid|Micardis|BIBR 277|4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid	telmisartan/hctz|telmisartan|t	DRUGBANK	DB00966	C33H30N4O2	small molecule	C09DA07|C09CA07|C09DB04	144701-48-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	RMMXLENWKUUMAY-UHFFFAOYSA-N
33228	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	10294	Benzoic acid, 4-(2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl)-, (E)-	Q27283498|M531IV9E0V|NCGC00370835-06|(E)-4-(2-(5,5-DIMETHYL-8-PHENYL-5,6-DIHYDRONAPHTHALEN-2-YL)VINYL)BENZOICACID|BMS453|BENZOIC ACID, 4-(2-(5,6-DIHYDRO-5,5-DIMETHYL-8-PHENYL-2-NAPHTHALENYL)ETHENYL)-, (E)-|BMS 453|BENZOIC ACID, 4-((1E)-2-(5,6-DIHYDRO-5,5-DIMETHYL-8-PHENYL-2-NAPHTHALENYL)ETHENYL)-|4-[(E)-2-(5,5-DIMETHYL-8-PHENYL-5,6-DIHYDRONAPHTHALEN-2-YL)VINYL]BENZOIC ACID|4-[(1E)-2-(5,6-DIHYDRO-5,5-DIMETHYL -8-PHENYL-2-NAPHTHALENYL)ETHENYL]-BENZOIC ACID|164108-16-1|BMS-189453|BMS189453|4-[(1E)-2-(5,6-DIHYDRO-5,5-DIMETHYL-8-PHENYL-2-NAPHTHALENYL)ETHENYL]-BENZOIC ACID|166977-43-1|BMS-189453, >=98% (HPLC)|4-[(E)-2-(5,5-DIMETHYL-8-PHENYL-6H-NAPHTHALEN-2-YL)ETHENYL]BENZOIC ACID|UNII-M531IV9E0V|J-010327|BMS 189453|A899389|BMS 453;BMS453;BMS 189453;BMS-189453;BMS189453|AC-36599|EX-A4818|(E)-4-[2-(5,5-DIMETHYL-8-PHENYL-5,6-DIHYDRONAPHTHALEN-2-YL)VINYL]BENZOIC ACID|BMS-453|(E)-4-(2-(5,5-DIMETHYL-8-PHENYL-5,6-DIHYDRONAPHTHALEN-2-YL)VINYL)BENZOIC ACID|AKOS024457612|CS-0019762|BENZOIC ACID, 4-[(1E)-2-(5,6-DIHYDRO-5,5-DIMETHYL-8-PHENYL-2-NAPHTHALENYL)ETHENYL]-|HY-100608|E)-4-[2-(5,6-DIHYDRO-5,5-DIMETHYL-8-PHENYL-2-NAPHTHALENYL)ETHENYL]-BENZOIC ACID|AS-16498	-	PUBCHEM	9875424	C27H24O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	VUODRPPTYLBGFM-CMDGGOBGSA-N
33229	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2023)	37112982	246119	10295	Nomilin	NSC 297134|NOMILIN|1-(ACETYLOXY)-1,2-DIHYDROOBACUNOIC ACID ETA-LACTONE|DRM0753K4T|AC1L2HUM|AC-34406|AI3-37935|1-(ACETYLOXY)-1,2-DIHYDROOBACUNOIC ACID .EPISLON.-LACTONE|NSC-297134|(1S,3AS,4AR,4BR,6AR,11S,11AR,11BR,13AS)-1-(FURAN-3-YL)-4B,7,7,11A,13A-PENTAMETHYL-3,5,9-TRIOXOHEXADECAHYDROOXEPINO[4',3':3,4]BENZO[1,2-F]OXIRENO[2,3-D]ISOCHROMEN-11-YL ACETATE|C08773|1-(ACETYLOXY)-1,2-DIHYDROOBACUNOIC ACID .EPSILON.-LACTONE|KST-1A9791|AKOS037514753|G3L|OBACUNOIC ACID, 1-(ACETYLOXY)-1,2-DIHYDRO-, ETA-LACTONE|1-(ACETYLOXY)-1,2-DIHYDROOBACUNOIC ACID E-LACTONE|AC1Q6OA3|1063-77-0|UNII-DRM0753K4T|(3-FURYL-PENTAMETHYL-TRIOXO-[?]YL) ACETATE|(1S,3AS,4AR,4BR,6AR,11S,11AR,11BR,13AS)-11-(ACETYLOXY)-1-(3-FURANYL)DECAHYDRO-4B,7,7,11A,13A-PENTAMETHYLOXIRENO(4,4A)-2-BENZOPYRAN(6,5-G)(2)BENZOXEPIN-3,5,9(3AH,4BH,6H)-TRIONE|CS-0009075|NOMILIN [MI]|HY-N0547|FT-0603541|Q1191572|SR-05000002184|(1R,2R,4S,7R,8S,11R,12R,13S,18R)-7-(FURAN-3-YL)-1,8,12,17,17-PENTAMETHYL-5,15,20-TRIOXO-3,6,16-TRIOXAPENTACYCLO[9.9.0.0?,?.0?,?.0??,??]ICOSAN-13-YL ACETATE|SR-05000002184-2	-	PUBCHEM	72320	C28H34O9	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding	KPDOJFFZKAUIOE-WNGDLQANSA-N
33230	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Uppal T (2022)	37192863	246225	7927	Dasabuvir	N-{6-[3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide|Sodium 3-(3-tert-butyl-4-methoxy-5-{6 [(methylsulfonyl)amino]naphthalene-2-yl}phenyl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ide hydrate (1:1:1)	viekira pak|viekira xr|holkira	DRUGBANK	DB09183	C26H27N3O5S	small molecule	J05AX16|J05AX66	1132935-63-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor	NBRBXGKOEOGLOI-UHFFFAOYSA-N
33231	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Jana ID (2022)	36712339	246226	1250	Posaconazole	-	posanol|noxafil	DRUGBANK	DB01263	C37H42F2N8O4	small molecule	J02AC04	171228-49-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Spike-Ace Interaction Inhibitor	RAGOYPUPXAKGKH-XAKZXMRKSA-N
33232	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Roy A (2022)	35598780	234382	10296	N-[4-[(thieno[2,3-d]pyrimidin-4-ylamino)sulfamoyl]phenyl]acetamide	HMS1662H21|CCG-242450	-	PUBCHEM	2808616	C14H13N5O3S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: nsp3 MAC1 inhibitor	HPLMIOJDTKVKPA-UHFFFAOYSA-N
33233	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Roy A (2022)	35598780	234382	10297	N-[(3-chlorophenyl)methyl]-3,5-dimethoxy-N-[3-oxo-3-(piperazin-1-yl)propyl]benzamide	N-[(3-CHLOROPHENYL)METHYL]-3,5-DIMETHOXY-N-[3-OXO-3-(PIPERAZIN-1-YL)PROPYL]BENZAMIDE|AKOS004971231	-	PUBCHEM	50779772	C23H28ClN3O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: nsp3 MAC1 inhibitor	YGTGHRPCPIFMSM-UHFFFAOYSA-N
33234	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Roy A (2022)	35598780	234382	10298	{5-[1-(3-Bromobenzoyl)-4-piperidyl]pyrazolo[1,5-a]pyridin-3-yl}(piperidino)methanone	{5-[1-(3-BROMOBENZOYL)-4-PIPERIDYL]PYRAZOLO[1,5-A]PYRIDIN-3-YL}(PIPERIDINO)METHANONE|AKOS005060713	-	PUBCHEM	50849069	C25H27BrN4O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: nsp3 MAC1 inhibitor	FZEFXPYPDXOKEG-UHFFFAOYSA-N
33235	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Roy A (2022)	35598780	234382	10299	{5-[1-(4-Bromobenzoyl)-4-piperidyl]pyrazolo[1,5-a]pyridin-3-yl}(piperidino)methanone	{5-[1-(4-BROMOBENZOYL)-4-PIPERIDYL]PYRAZOLO[1,5-A]PYRIDIN-3-YL}(PIPERIDINO)METHANONE|AKOS005060452	-	PUBCHEM	50848809	C25H27BrN4O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: nsp3 MAC1 inhibitor	FORPAFQIIOPZTB-UHFFFAOYSA-N
33236	4383888	14254602	G128_gp01ab_nsp3	nsp3ab	ORF1ab|nsp3|rep|1AB|MERS-CoV nsp3|orf1ab-nsp3|orf1ab-nsp3ab|nsp3ab|Papain-like proteinase|R1AB_CVEMC|PRO_0000422441	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor	target	Roy A (2022)	35598780	234382	10296	N-[4-[(thieno[2,3-d]pyrimidin-4-ylamino)sulfamoyl]phenyl]acetamide	HMS1662H21|CCG-242450	-	PUBCHEM	2808616	C14H13N5O3S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: nsp3 MAC1 inhibitor	HPLMIOJDTKVKPA-UHFFFAOYSA-N
33237	4383888	14254602	G128_gp01ab_nsp3	nsp3ab	ORF1ab|nsp3|rep|1AB|MERS-CoV nsp3|orf1ab-nsp3|orf1ab-nsp3ab|nsp3ab|Papain-like proteinase|R1AB_CVEMC|PRO_0000422441	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor	target	Roy A (2022)	35598780	234382	10298	{5-[1-(3-Bromobenzoyl)-4-piperidyl]pyrazolo[1,5-a]pyridin-3-yl}(piperidino)methanone	{5-[1-(3-BROMOBENZOYL)-4-PIPERIDYL]PYRAZOLO[1,5-A]PYRIDIN-3-YL}(PIPERIDINO)METHANONE|AKOS005060713	-	PUBCHEM	50849069	C25H27BrN4O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: nsp3 MAC1 inhibitor	FZEFXPYPDXOKEG-UHFFFAOYSA-N
33238	4383888	14254602	G128_gp01ab_nsp3	nsp3ab	ORF1ab|nsp3|rep|1AB|MERS-CoV nsp3|orf1ab-nsp3|orf1ab-nsp3ab|nsp3ab|Papain-like proteinase|R1AB_CVEMC|PRO_0000422441	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor	target	Roy A (2022)	35598780	234382	10299	{5-[1-(4-Bromobenzoyl)-4-piperidyl]pyrazolo[1,5-a]pyridin-3-yl}(piperidino)methanone	{5-[1-(4-BROMOBENZOYL)-4-PIPERIDYL]PYRAZOLO[1,5-A]PYRIDIN-3-YL}(PIPERIDINO)METHANONE|AKOS005060452	-	PUBCHEM	50848809	C25H27BrN4O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: nsp3 MAC1 inhibitor	FORPAFQIIOPZTB-UHFFFAOYSA-N
33239	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Kladnik J (2022)	35943189	234390	8326	ZnPT, zinc pyrithione	Pyrithione zinc|Zinc bis(pyridine-2-thiolate 1-oxide)|2295|R953O2RHZ5|2-Pyridinethiol, 1-oxide, zinc salt (2:1)|Zinc bis(2-pyridinethiolate 1-oxide)	-	CHEMSPIDER	24255	C10H8N2O2S2Zn	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	OTPSWLRZXRHDNX-UHFFFAOYSA-L
33241	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov-2 inhibitor	target	Ding S (2022)	35677392	233874	10190	VE607	1-[3-(2-Hydroxy-3-piperidin-1-yl-propoxy)-phenoxy]-3-piperidin-1-yl-propan-2-ol|3,3'-[1,3-Phenylenebis(oxy)]bis[1-(1-piperidinyl)-2-propanol]|1-Piperidineethanol, alpha,alpha'-[1,3-phenylenebis(oxymethylene)]bis-	-	CHEMSPIDER	2386276	C22H36N2O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (experimental)	FHFSLXLDKXBOQN-UHFFFAOYSA-N
33242	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Ding S (2022)	35677392	233874	10190	VE607	1-[3-(2-Hydroxy-3-piperidin-1-yl-propoxy)-phenoxy]-3-piperidin-1-yl-propan-2-ol|3,3'-[1,3-Phenylenebis(oxy)]bis[1-(1-piperidinyl)-2-propanol]|1-Piperidineethanol, alpha,alpha'-[1,3-phenylenebis(oxymethylene)]bis-	-	CHEMSPIDER	2386276	C22H36N2O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (experimental)	FHFSLXLDKXBOQN-UHFFFAOYSA-N
33244	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Li C (2022)	35836239	232861	10281	ANTHRAQUINONE	Anthraquinone|9,10-Anthracenedione|9,10-Anthraquinone|390030|MFCD00001188|CB4725000	-	CHEMSPIDER	13835294	C14H8O2	small molecule	-	84-65-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	RZVHIXYEVGDQDX-UHFFFAOYSA-N
33245	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Li C (2022)	35836239	232861	10252	TANNIC ACID	Gallotannin|Glycerite|MFCD00066397|Tannic acid, beta|tannic acid|Tanninum|beta-D-Glucopyranose, pentakis[3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]benzoate]|1,2,3,4,6-Pentakis-O-{3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]benzoyl}-beta-D-glucopyranose	-	CHEMSPIDER	17286569	C76H52O46	small molecule	-	5424-20-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	LRBQNJMCXXYXIU-PPKXGCFTSA-N
33246	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Li C (2022)	35836239	232861	10217	9-Methoxycanthin-6-one	8-Methoxycanthin-6-one|6H-Indolo[3,2,1-de][1,5]naphthyridin-6-one, 9-methoxy-|9-methoxycanthin-6-one|9-Methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one	-	CHEMSPIDER	8057099	C15H10N2O2	small molecule	-	74991-91-6	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike and ACE2 binding (computational)	OWCRARVHWCCRAG-UHFFFAOYSA-N
33247	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Li C (2022)	35836239	232861	10177	Nafamostat mesylate	Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester, methanesulfonate (1:2)|6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate methanesulfonate (1:2)|6-Carbamimidoyl-2-naphthyl 4-carbamimidamidobenzoate methanesulfonate (1:2)|Nafamostat (mesylate)|MFCD00941430|DG2736000|1D2T74921W|4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate|Nafamostat mesylate|Nafamostat Mesilate	-	CHEMSPIDER	49623	C21H25N5O8S2	small molecule	-	82956-11-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	SRXKIZXIRHMPFW-UHFFFAOYSA-N
33248	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov-2 inhibitor	target	Ho TY (2007)	16730806	242471	6518	Emodin	3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE|Emodin|Emodol|Frangula Emodin|Schuttgelb|1,3,8-Trihydroxy-6-Methylanthracene-9,10-Dione|Rheum Emodin|Archin	-	DRUGBANK	DB07715	C15H10O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	RHMXXJGYXNZAPX-UHFFFAOYSA-N
33254	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov-2 inhibitor	target	Jansen-Olliges L (2022)	36611877	240222	1014	Mycophenolic acid	Acide mycophenolique|Micofenolico acido|Acido micofenolico|Mycophenolate|Mycophenolsure|(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid|Acidum mycophenolicum	myfortic|mycophenolic acid|apo	DRUGBANK	DB01024	C17H20O6	small molecule	L04AA06	24280-93-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	HPNSFSBZBAHARI-RUDMXATFSA-N
33255	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov-2 inhibitor	target	Jansen-Olliges L (2022)	36611877	240222	10282	cohaerin F	(7R,8R)-7-Hydroxy-3-(4-hydroxy-2-methyl-6-oxo-1-cyclohexen-1-yl)-7-methyl-8-(3-methyl-2-oxononyl)-7,8-dihydro-6H-isochromen-6-one|6H-2-Benzopyran-6-one, 7,8-dihydro-7-hydroxy-3-(4-hydroxy-2-methyl-6-oxo-1-cyclohexen-1-yl)-7-methyl-8-(3-methyl-2-oxononyl)-, (7R,8R)-	-	CHEMSPIDER	9865793	C27H36O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	MDZAMUBMPBLGAO-MMMYSLHOSA-N
33256	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov-2 inhibitor	target	Jansen-Olliges L (2022)	36611877	240222	10236	cohaerin C	(6aR,9S,9aR)-3-(4-Hydroxy-2-methyl-6-oxo-1-cyclohexen-1-yl)-6a-methyl-9-(2-methyloctanoyl)-9,9a-dihydro-6H-furo[2,3-h]isochromene-6,8(6aH)-dione|6H-Furo[2,3-h]-2-benzopyran-6,8(6aH)-dione, 9,9a-dihydro-3-(4-hydroxy-2-methyl-6-oxo-1-cyclohexen-1-yl)-6a-methyl-9-(2-methyl-1-oxooctyl)-, (6aR,9S,9aR)-	-	CHEMSPIDER	78437274	C28H34O7	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	GKKNMNFXYPXAOJ-GNEHSSTKSA-N
33257	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov-2 inhibitor	target	Jansen-Olliges L (2022)	36611877	240222	10219	multiformin C	(6aS)-3-(2-Hydroxy-6-methylphenyl)-6a-methyl-9-(2-methylbutanoyl)-6H-furo[2,3-h]isochromene-6,8(6aH)-dione|6H-Furo[2,3-h]-2-benzopyran-6,8(6aH)-dione, 3-(2-hydroxy-6-methylphenyl)-6a-methyl-9-(2-methyl-1-oxobutyl)-, (6aS)-	-	CHEMSPIDER	9756982	C24H22O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	PDIQMKRQFHBXJF-JGRONMTFSA-N
33258	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Puhl AC (2022)	35983371	240395	1124	Carvedilol	(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol|Carvedilolum|SKF 105517|Carvedilol	novo-carvedilol tablets|mylan-	DRUGBANK	DB01136	C24H26N2O4	small molecule	C07AG02	72956-09-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Spike binding (experimental)	OGHNVEJMJSYVRP-UHFFFAOYSA-N
33259	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Invernizzi L (2022)	35419694	241007	10214	punicalagin	MFCD09838017|Punicalagin	-	CHEMSPIDER	29272136	C48H28O30	small molecule	-	65995-63-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike or ACE2 binding undetermined	ZJVUMAFASBFUBG-UYMKNUMKSA-N
33260	4383861	43740578	GU280_gp01_nsp13	nsp13	ORF1ab|ORF1ab-nsp13|Hel|SARS-CoV2 nsp13|SARS-CoV-2 nsp13|Helicase|R1AB_SARS2|PRO_0000449630	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Lu L (2022)	35985407	241008	10214	punicalagin	MFCD09838017|Punicalagin	-	CHEMSPIDER	29272136	C48H28O30	small molecule	-	65995-63-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral nsp13 inhibitor, antiviral activity against SARS-CoV-2 BetaCoV/Shenzhen/SZTH-003/2020	ZJVUMAFASBFUBG-UYMKNUMKSA-N
33261	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Du R (2021)	33872675	241010	10214	punicalagin	MFCD09838017|Punicalagin	-	CHEMSPIDER	29272136	C48H28O30	small molecule	-	65995-63-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral nsp5 inhibitor	ZJVUMAFASBFUBG-UYMKNUMKSA-N
33262	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Du R (2021)	33872675	241010	10226	chebulagic acid	chebulagic acid	-	CHEMSPIDER	391031	C41H30O27	small molecule	-	23094-71-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral nsp5 inhibitor	HGJXAVROWQLCTP-YABCKIEDSA-N
33263	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Li H (2021)	34586788	241011	7605	Ellagic Acid	2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione|Benzoaric acid|Elagostasine|Lagistase|476-66-4|Alizarine Yellow	-	DRUGBANK	DB08846	C14H6O8	small molecule	-	476-66-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral nsp5 inhibitor	AFSDNFLWKVMVRB-UHFFFAOYSA-N
33264	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Xiang Y (2023)	36521705	241019	10156	Ginkgolic acid C17:1 (GA171)	Ginkgolic Acid C17:1|2-[(10Z)-Heptadec-10-en-1-yl]-6-hydroxybenzoic acid|Benzoic acid, 2-[(10Z)-10-heptadecen-1-yl]-6-hydroxy-|6-[(10Z)-Heptadecenyl]salicylic acid|Ginkgolic acid II|2-[(10Z)-10-Heptadecen-1-yl]-6-hydroxybenzoic acid|MFCD09752804	-	CHEMSPIDER	4580130	C24H38O3	small molecule	-	111047-30-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike and ACE2 binding (experimental), antiviral activity against SARS-CoV-2 Delta, Gamma, and Omicron variants	MBYNDKVOZOAOIS-FPLPWBNLSA-N
33265	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Bertini S (2022)	35322395	232831	676	Pentosan Polysulfate	Pentosane polysulfate|Pentosanpolysulfat|Pentosan sulfuric polyester|Pentosano polisulfato|Pentosani polysulfas	elmiron	DRUGBANK	DB00686	C10H18O21S4	small molecule	C05BA04|G04BX15	37300-21-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike binding (experimental)	FCCNSUIJIOOXEZ-SJYYZXOBSA-N
33270	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10300	(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	-	PUBCHEM	162685261	C26H45N5O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	BKEPDWNBCUBDEN-KOUJMVCDSA-N
33271	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10301	(1R,2S,5S)-N-[(2S,3S)-4-amino-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]-3-sulfanylbutan-2-yl]-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	I70	-	PUBCHEM	162640229	C27H46N6O6S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	IWWUKKKRPZXUGC-LJRYSRKVSA-N
33272	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10302	(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S,3R)-4-(cyclopropylmethylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	-	PUBCHEM	164575876	C31H52N6O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	RTEPKJZIQYUGOI-BLTUZGSGSA-N
33273	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10303	(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S,3R)-4-(ethylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	-	PUBCHEM	164575892	C29H50N6O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	GKUBEDOOUKCUOW-YTNBPZCUSA-N
33274	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10304	(1R,2S,5S)-N-[(2S,3R)-4-(butylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	-	PUBCHEM	164575877	C31H54N6O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	CYAFTCDKLGXDCI-BLTUZGSGSA-N
33275	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10305	(1R,2S,5S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S,3R)-4-(hexylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	-	PUBCHEM	164575878	C33H58N6O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	NSGOBCXXBBPKSX-FQCPSNFCSA-N
33276	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10306	(1R,2S,5S)-N-[(2S,3R)-4-(benzylamino)-3-hydroxy-4-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]butan-2-yl]-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	-	PUBCHEM	164575879	C34H52N6O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	WFDSDFTYLISRSE-ADSPCUKESA-N
33277	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10307	(6S)-5-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-5-azaspiro[2.4]heptane-6-carboxamide	-	-	PUBCHEM	164575891	C25H43N5O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	QPINBLRCPHAOCS-XLAORIBOSA-N
33278	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10308	Unk-Gly(tBu)-Ala(tBu)-Ala((S)-2-oxopyrrolidin-3-yl)-ol	-	-	PUBCHEM	164575890	C25H47N5O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	AXOUOMLRYWWRDK-XLAORIBOSA-N
33279	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Alugubelli YR (2021)	888800000489	232837	10309	(1R,2S,5S)-3-[(2S)-3,3-dimethyl-2-(3-methylbutanoylamino)butanoyl]-N-[(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	-	PUBCHEM	164575880	C26H44N4O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	YJDABKUOTKRKDF-RZCQQDKOSA-N
33285	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Chen KY (2022)	35278581	246228	4662	Merimepodib	MMPD	-	DRUGBANK	DB04862	C23H24N4O6	small molecule	-	198821-22-6	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	JBPUGFODGPKTDW-SFHVURJKSA-N
33286	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Ma C (2022)	35404564	232480	10196	KY-226	Benzamide, 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-|4-{[(4-Biphenylylmethyl)sulfanyl]methyl}-N-(hexylsulfonyl)benzamide	-	CHEMSPIDER	84393651	C27H31NO3S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	MKXMABKUVSOEJF-UHFFFAOYSA-N
33287	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Ma C (2022)	35404564	232480	10174	tropifexor	2-[(3-endo)-3-({5-Cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid|6-Benzothiazolecarboxylic acid, 2-[(3-endo)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl]methoxy]-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-|tropifexor|NMZ08KM76Z	-	CHEMSPIDER	59718652	C29H25F4N3O5S	small molecule	-	1383816-29-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	VYLOOGHLKSNNEK-PIIMJCKOSA-N
33288	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Ma C (2022)	35404564	232480	10189	EACC	Ethyl [(2-{[(5-nitro-2-thienyl)carbonyl]amino}-3-thienyl)carbonyl]carbamate|Carbamic acid, N-[[2-[[(5-nitro-2-thienyl)carbonyl]amino]-3-thienyl]carbonyl]-, ethyl ester	-	CHEMSPIDER	2936247	C13H11N3O6S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	ISLJZDYAPAUORR-UHFFFAOYSA-N
33289	4383941	1489680	SARS-CoV-1ab-nsp3ab	nsp3ab	nsp3|sars1ab|orf1ab|SARS-CoV nsp3ab|SARS-CoV nsp3|SARS-CoV sars1ab|orf1ab-nsp3|orf1ab-nsp3ab|pp1ab|Papain-like proteinase|PL-PRO|PL2-PRO|R1AB_CVHSA|PRO_0000037311	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Ma C (2022)	35404564	232480	10196	KY-226	Benzamide, 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-|4-{[(4-Biphenylylmethyl)sulfanyl]methyl}-N-(hexylsulfonyl)benzamide	-	CHEMSPIDER	84393651	C27H31NO3S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: PLPro inhibitor	MKXMABKUVSOEJF-UHFFFAOYSA-N
33290	4383941	1489680	SARS-CoV-1ab-nsp3ab	nsp3ab	nsp3|sars1ab|orf1ab|SARS-CoV nsp3ab|SARS-CoV nsp3|SARS-CoV sars1ab|orf1ab-nsp3|orf1ab-nsp3ab|pp1ab|Papain-like proteinase|PL-PRO|PL2-PRO|R1AB_CVHSA|PRO_0000037311	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Ma C (2022)	35404564	232480	10174	tropifexor	2-[(3-endo)-3-({5-Cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid|6-Benzothiazolecarboxylic acid, 2-[(3-endo)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl]methoxy]-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-|tropifexor|NMZ08KM76Z	-	CHEMSPIDER	59718652	C29H25F4N3O5S	small molecule	-	1383816-29-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: PLPro inhibitor	VYLOOGHLKSNNEK-PIIMJCKOSA-N
33291	4383941	1489680	SARS-CoV-1ab-nsp3ab	nsp3ab	nsp3|sars1ab|orf1ab|SARS-CoV nsp3ab|SARS-CoV nsp3|SARS-CoV sars1ab|orf1ab-nsp3|orf1ab-nsp3ab|pp1ab|Papain-like proteinase|PL-PRO|PL2-PRO|R1AB_CVHSA|PRO_0000037311	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Ma C (2022)	35404564	232480	10189	EACC	Ethyl [(2-{[(5-nitro-2-thienyl)carbonyl]amino}-3-thienyl)carbonyl]carbamate|Carbamic acid, N-[[2-[[(5-nitro-2-thienyl)carbonyl]amino]-3-thienyl]carbonyl]-, ethyl ester	-	CHEMSPIDER	2936247	C13H11N3O6S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: PLPro inhibitor	ISLJZDYAPAUORR-UHFFFAOYSA-N
33292	4383888	14254602	G128_gp01ab_nsp3	nsp3ab	ORF1ab|nsp3|rep|1AB|MERS-CoV nsp3|orf1ab-nsp3|orf1ab-nsp3ab|nsp3ab|Papain-like proteinase|R1AB_CVEMC|PRO_0000422441	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor	target	Ma C (2022)	35404564	232480	10174	tropifexor	2-[(3-endo)-3-({5-Cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid|6-Benzothiazolecarboxylic acid, 2-[(3-endo)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-4-isoxazolyl]methoxy]-8-azabicyclo[3.2.1]oct-8-yl]-4-fluoro-|tropifexor|NMZ08KM76Z	-	CHEMSPIDER	59718652	C29H25F4N3O5S	small molecule	-	1383816-29-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS direct chemical interaction: PLPro inhibitor	VYLOOGHLKSNNEK-PIIMJCKOSA-N
33296	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Li J (2022)	35389231	232203	9961	Paxlovid	(1R,2S,5S)-N-{(1S)-1-Cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide|3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]butyl]-6,6-dimethyl-, (1R,2S,5S)-|(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	CHEMSPIDER	114826566	C23H32F3N5O4	small molecule	-	2628280-40-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	LIENCHBZNNMNKG-OJFNHCPVSA-N
33297	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Li J (2022)	35389231	232203	9961	Paxlovid	(1R,2S,5S)-N-{(1S)-1-Cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide|3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]butyl]-6,6-dimethyl-, (1R,2S,5S)-|(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	CHEMSPIDER	114826566	C23H32F3N5O4	small molecule	-	2628280-40-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	LIENCHBZNNMNKG-OJFNHCPVSA-N
33298	4383890	14254602	G128_gp01ab_nsp5	nsp5ab	ORF1ab|nsp5|rep|1AB|MERS-CoV nsp5|orf1ab-nsp5|orf1ab-nsp5ab|nsp5ab|3C-like proteinase|R1AB_CVEMC|PRO_0000422443	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor	target	Li J (2022)	35389231	232203	9961	Paxlovid	(1R,2S,5S)-N-{(1S)-1-Cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide|3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]butyl]-6,6-dimethyl-, (1R,2S,5S)-|(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide	-	CHEMSPIDER	114826566	C23H32F3N5O4	small molecule	-	2628280-40-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor, and MERS activity in PMID: 34726479	LIENCHBZNNMNKG-OJFNHCPVSA-N
33299	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Zhang Q (2022)	35440680	232187	1192	Mitoxantrone	Mitoxantrona|Mitoxantronum|Mitoxantrone|1,4-DIHYDROXY-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthracenedione	mitoxantrone injection|mitoxan	DRUGBANK	DB01204	C22H28N4O6	small molecule	L01DB07	65271-80-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-heparin interaction inhibitor	KKZJGLLVHKMTCM-UHFFFAOYSA-N
33300	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Meewan I (2022)	35745663	232197	10259	Dimorpholinethiuram disulfide	Dimorpholinethiuram disulfide|Bis(morpholinothiocarbonyl) disulfide|Dimorpholin-4-yldithioperoxyanhydride|MFCD00072237|di(4-morpholinyl)dithioperoxyanhydride|Di-4-morpholinyldithioperoxyanhydride	-	CHEMSPIDER	12359	C10H16N2O2S4	small molecule	-	729-46-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	KKVYOWPPMNSLCP-UHFFFAOYSA-N
33301	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Meewan I (2022)	35745663	232197	10259	Dimorpholinethiuram disulfide	Dimorpholinethiuram disulfide|Bis(morpholinothiocarbonyl) disulfide|Dimorpholin-4-yldithioperoxyanhydride|MFCD00072237|di(4-morpholinyl)dithioperoxyanhydride|Di-4-morpholinyldithioperoxyanhydride	-	CHEMSPIDER	12359	C10H16N2O2S4	small molecule	-	729-46-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	KKVYOWPPMNSLCP-UHFFFAOYSA-N
33302	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Meewan I (2022)	35745663	232197	10193	Thiram	Thiram|Nomersan|Thiuramyl|Tiuramyl|Thiurad|Thylate|Tulisan|Tyradin|Tuads|Vanguard GF|Tetramethylthiuram disulfide|Bis(dimethylthiocarbamoyl) disulfide|Bis(dimethylthiocarbamyl) disulfide|Bis[(dimethylamino)carbonothioyl] disulfide|Basultra|Betoxin|[Dithiobis(carbonothioylnitrilo)]tetramethane|[Disulfanediylbis(carbonothioylnitrilo)]tetramethane|Methane, [dithiobis(carbonothioylnitrilo)]tetrakis-|[Disulfanediylbis(carbonothioylnitrilo)]tetramethan|Methane, 1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetrakis-|MFCD00008325|JO1400000	-	CHEMSPIDER	5256	C6H12N2S4	small molecule	-	137-26-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	KUAZQDVKQLNFPE-UHFFFAOYSA-N
33303	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Meewan I (2022)	35745663	232197	10193	Thiram	Thiram|Nomersan|Thiuramyl|Tiuramyl|Thiurad|Thylate|Tulisan|Tyradin|Tuads|Vanguard GF|Tetramethylthiuram disulfide|Bis(dimethylthiocarbamoyl) disulfide|Bis(dimethylthiocarbamyl) disulfide|Bis[(dimethylamino)carbonothioyl] disulfide|Basultra|Betoxin|[Dithiobis(carbonothioylnitrilo)]tetramethane|[Disulfanediylbis(carbonothioylnitrilo)]tetramethane|Methane, [dithiobis(carbonothioylnitrilo)]tetrakis-|[Disulfanediylbis(carbonothioylnitrilo)]tetramethan|Methane, 1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetrakis-|MFCD00008325|JO1400000	-	CHEMSPIDER	5256	C6H12N2S4	small molecule	-	137-26-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	KUAZQDVKQLNFPE-UHFFFAOYSA-N
33308	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Puhl AC (2022)	35609344	231752	10161	Pyronaridine	Pyronaridine|4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol|4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol|Phenol, 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-|4-({7-chloro-2-methoxybenzo[b]1,5-naphthyridin-10-yl}amino)-2,6-bis[(pyrrolidin-1-yl)methyl]phenol|4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol	-	CHEMSPIDER	10647812	C29H32ClN5O2	small molecule	-	74847-35-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	DJUFPMUQJKWIJB-UHFFFAOYSA-N
33309	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Chaves OA (2022)	35759391	231762	5560	Apixaban	apixabn|apixabanum	eliquis	DRUGBANK	DB06605	C25H25N5O4	small molecule	B01AF02	503612-47-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	QNZCBYKSOIHPEH-UHFFFAOYSA-N
33310	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Chaves OA (2022)	35759391	231762	5535	Rivaroxaban	Xarelto|BAY 59-7939|BAY59-7939	xarelto	DRUGBANK	DB06228	C19H18ClN3O5S	small molecule	B01AF01	366789-02-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	KGFYHTZWPPHNLQ-AWEZNQCLSA-N
33311	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Chaves OA (2022)	35759391	231762	10206	GC376	Sodium (2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-(2-oxo-3-pyrrolidinyl)-1-propanesulfonate|3-Pyrrolidinepropanesulfonic acid, alpha-hydroxy-beta-[[(2S)-4-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]pentyl]amino]-2-oxo-, sodium salt, (betaS)- (1:1)	-	CHEMSPIDER	29396096	C21H30N3NaO8S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	BSPJDKCMFIPBAW-JPBGFCRCSA-M
33312	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Chaves OA (2022)	35759391	231762	5577	Dabigatran etexilate	Ethyl 3-[[[4-[[[(hexyloxyl)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino] propanoate|Dabigatran	pradaxa	DRUGBANK	DB06695	C34H41N7O5	small molecule	B01AE07	211915-06-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	KSGXQBZTULBEEQ-UHFFFAOYSA-N
33313	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Thoene J (2022)	36115282	231753	10210	Cysteamine HCl	mea hydrochloride|Cysteamine Hydrochloride|2-Aminoethanethiol Hydrochloride|2-Mercaptoethylammonium chloride|2-Mercaptoethylamine hydrochloride|1-Aminoethane-2-thiol hydrochloride|.beta.-Mercaptoethylamine hydrochloride|1-Amino-2-mercaptoethane hydrochloride|2-Mercapto  ethyl  amine hydrochloride|beta-Mercapto  ethylamine hydrochloride|Cysteinamine Hydrochloride|b-Mercaptoethylamine Hydrochloride|2-Mercaptoethanamine Hydrochloride|Aminoethanethiol hydrochloride|Ethanethiol, 2-amino-, hydrochloride (1:1)|2-Aminoethanethiol hydrochloride (1:1)|IF1B771SVB|2-amino-ethanethiol, monohydrochloride|KJ0200000	-	CHEMSPIDER	8729	C2H8ClNS	small molecule	-	16904-32-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, effective against alpha, beta, lambda, gamma, delta and omicron variants	OGMADIBCHLQMIP-UHFFFAOYSA-N
33314	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Cao L (2022)	35579533	231759	10205	ATV006	[(2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methyl 2-methylpropanoate (non-preferred name)	-	CHEMSPIDER	115037299	C16H19N5O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor; effective against early strain B.1, and two prevalent SARS-CoV variants of concern (VOC), the Beta (B.1.351) and Delta (B.1.671.2) variants	YIHPGVCWGSURHO-VSBTWAGUSA-N
33315	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Vandyck K (2021)	34029993	243376	10231	PF-07304814	1H-Indole-2-carboxamide, 4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]-|(3S)-3-({N-[(4-Methoxy-1H-indol-2-yl)carbonyl]-L-leucyl}amino)-2-oxo-4-[(3S)-2-oxo-3-pyrrolidinyl]butyl dihydrogen phosphate	-	CHEMSPIDER	114935506	C24H33N4O9P	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	FQKALOFOWPDTED-WBAXXEDZSA-N
33316	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2021)	35062273	231003	10194	NBCoV1	(Z)-2-Chloro-5-(5-((4-oxo-3-phenethyl-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid|MFCD03103051|Benzoic acid, 2-chloro-5-[5-[(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-|2-Chloro-5-(5-{(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)benzoic acid	-	CHEMSPIDER	1701907	C23H16ClNO4S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, NBCoV Small Molecules Neutralize the SARS-CoV-2 Variants B.1.1.7 UK (Alpha), B.1.351 RSA (Beta), and B.1.617.2 India (Delta)	NWSIRTZGRAGTPQ-MOSHPQCFSA-N
33317	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov inhibitor	target	Curreli F (2021)	35062273	231003	10194	NBCoV1	(Z)-2-Chloro-5-(5-((4-oxo-3-phenethyl-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid|MFCD03103051|Benzoic acid, 2-chloro-5-[5-[(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-|2-Chloro-5-(5-{(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)benzoic acid	-	CHEMSPIDER	1701907	C23H16ClNO4S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction : Spike-ACE2 interaction inhibitor	NWSIRTZGRAGTPQ-MOSHPQCFSA-N
33318	4383879	14254594	G128_gp02	S	spike|MERS-CoV S|MERS-CoV spike|S protein|surface|SPIKE_CVEMC|PRO_0000422465	1335626	Middle-East Respiratory Syndrome-related Coronavirus	mers-cov inhibitor	target	Curreli F (2021)	35062273	231003	10194	NBCoV1	(Z)-2-Chloro-5-(5-((4-oxo-3-phenethyl-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid|MFCD03103051|Benzoic acid, 2-chloro-5-[5-[(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-|2-Chloro-5-(5-{(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)benzoic acid	-	CHEMSPIDER	1701907	C23H16ClNO4S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction : Spike-ACE2 interaction inhibitor	NWSIRTZGRAGTPQ-MOSHPQCFSA-N
33319	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Curreli F (2021)	35062273	231003	10241	NBCoV2	Benzoic acid, 3-[5-[(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-|3-(5-{(Z)-[4-Oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)benzoic acid	-	CHEMSPIDER	24635738	C23H17NO4S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, NBCoV Small Molecules Neutralize the SARS-CoV-2 Variants B.1.1.7 UK (Alpha), B.1.351 RSA (Beta), and B.1.617.2 India (Delta)	WAJXCRXCBWHFKY-ZHZULCJRSA-N
33320	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov inhibitor	target	Curreli F (2021)	35062273	231003	10241	NBCoV2	Benzoic acid, 3-[5-[(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-|3-(5-{(Z)-[4-Oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)benzoic acid	-	CHEMSPIDER	24635738	C23H17NO4S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction : Spike-ACE2 interaction inhibitor	WAJXCRXCBWHFKY-ZHZULCJRSA-N
33321	4383879	14254594	G128_gp02	S	spike|MERS-CoV S|MERS-CoV spike|S protein|surface|SPIKE_CVEMC|PRO_0000422465	1335626	Middle-East Respiratory Syndrome-related Coronavirus	mers-cov inhibitor	target	Curreli F (2021)	35062273	231003	10241	NBCoV2	Benzoic acid, 3-[5-[(Z)-[4-oxo-3-(2-phenylethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-|3-(5-{(Z)-[4-Oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)benzoic acid	-	CHEMSPIDER	24635738	C23H17NO4S2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction : Spike-ACE2 interaction inhibitor	WAJXCRXCBWHFKY-ZHZULCJRSA-N
33324	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Latha D (2022)	35403091	246232	10249	Andrographidine C	Andrographidine C|7,8-Dimethoxy-4-oxo-2-phenyl-4H-chromen-5-yl beta-D-glucopyranoside|4H-1-Benzopyran-4-one, 5-(beta-D-glucopyranosyloxy)-7,8-dimethoxy-2-phenyl-	-	CHEMSPIDER	10306100	C23H24O10	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor; target determined by molecular docking	WGCQDTNINMCFAY-PUIBNRJISA-N
33325	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Latha D (2022)	35403091	246232	1782	Kaempherol	-	-	DRUGBANK	DB01852	C15H10O6	small molecule	-	520-18-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, target determined by molecular docking	IYRMWMYZSQPJKC-UHFFFAOYSA-N
33326	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Latha D (2022)	35403091	246232	7740	Clinofibrate	-	-	DRUGBANK	DB09006	C28H36O6	small molecule	-	30299-08-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor, target determined by molecular docking	OGGAHXJZRRGBTK-UHFFFAOYNA-N
33327	4383850	43740578	GU280_gp01_nsp1	nsp1	ORF1ab|ORF1ab-nsp1|SARS-CoV2 nsp1|SARS-CoV-2 nsp1|leader protein|R1AB_SARS2|PRO_0000449619	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Kumar P (2022)	35425590	246233	10272	Mitoxantrone dihydrochloride	MITOZANTRONE|Novantron|Onkotrone|Mitoxantrone hydrochloride|Mitoxantrone dihydrochloride|MITOXANTHRONE HYDROCHLORIDE|1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride|1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthraquinone Dihydrochloride|novatrone|Mitoxantrone 2HCl|MITOXANTRONE HCl|9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-, hydrochloride (1:2)|1,4-Dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracen-9,10-diondihydrochlorid|1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione dihydrochloride|9,10-anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-, dihydrochloride|1,4-Dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthraquinone dihydrochloride|NSC-310739|MFCD00242943|UNII-U6USW86RD0|U6USW86RD0|CB5748500	-	CHEMSPIDER	46292	C22H30Cl2N4O6	small molecule	-	70476-82-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: NSP1 binder	ZAHQPTJLOCWVPG-UHFFFAOYSA-N
33328	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Schaefer A (2022)	35315683	246120	10182	GS-621763	(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-[(isobutyryloxy)methyl]tetrahydrofuran-3,4-diyl bis(2-methylpropanoate) (non-preferred name)	-	CHEMSPIDER	115010292	C24H31N5O7	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor	RVSSLHFYCSUAHY-JQGROFRJSA-N
33333	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Choudhary S (2022)	888800000862	239394	10284	Lithocholic acid	Lithocholic acid|3alpha-hydroxy-5beta-cholanic acid|3alpha-hydroxy-5beta-cholan-24-oic acid|3-alpha-Hydroxy-5-beta-cholanic acid|5beta-Cholan-24-oic acid, 3alpha-hydroxy-|(3alpha,5beta)-3-Hydroxycholan-24-oic acid|5-beta-Cholan-24-oic acid, 3-alpha-hydroxy-|4-10-00-00785 (Beilstein Handbook Reference)|Cholan-24-oic acid, 3-hydroxy-, (3alpha,5beta)-|Cholan-24-oic acid, 3-hydroxy-, (3-alpha,5-beta)- (9CI)|Cholan-24-oic acid, 3-hydroxy-, (3.alpha.,5.beta.)-|3a-Hydroxycholanic Acid|3a-Hydroxy-5b-cholan-24-oic Acid|17b-(1-Methyl-3-carboxypropyl)etiocholan-3a-ol|(3a,5b)-3-hydroxycholan-24-oic acid|(3a,5b)-3-hydroxy-cholan-24-oic acid|5beta-Cholan-24-oic acid-3alpha-ol|4-10-00-00785|(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid|3217757|cholan-24-oic acid, 3-hydroxy-, (3a,5b)-|MFCD00003682|5QU0I8393U|FZ2275000	-	CHEMSPIDER	9519	C24H40O3	small molecule	-	434-13-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	SMEROWZSTRWXGI-HVATVPOCSA-N
33334	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Thijssen V (2023)	37339194	246123	7626	Linagliptin	(R)-8-(3-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione|BI 1356|Tradjenta|BI-1356|Trajenta	jentadueto xr|glyxambi|tradjen	DRUGBANK	DB08882	C25H28N8O2	small molecule	A10BD19|A10BH05|A10BD11	668270-12-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	LTXREWYXXSTFRX-QGZVFWFLSA-N
33335	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Thijssen V (2023)	37339194	246123	10180	flupenthixol	2-Trifluoromethyl-9-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propylidene)thioxanthene|2-Trifluoromethyl-9-(3-(4-(beta-hydroxyethyl)-1-piperazinyl)propylidene)thioxanthene|2-Trifluoromethyl-9-[3-[4-(b-hydroxyethyl)-1-piperazinyl]propylidene]thioxanthene|trans-Flupenthixol|<i>trans</i>-flupenthixol|(E)-Flupentixol|FLUPENTIXOL, (E)-|1-Piperazineethanol, 4-[(3E)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-|trans-(E)-Flupentixol|trans-Flupentixol|2-(4-{(3E)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}-1-piperazinyl)ethanol|2-(4-{(3E)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol|Flupentiol	-	CHEMSPIDER	4445171	C23H25F3N2OS	small molecule	-	53772-85-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	NJMYODHXAKYRHW-BLLMUTORSA-N
33336	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Thijssen V (2023)	37339194	246123	10312	Teneligliptin	Q15269678|((2S,4S)-4-(4-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)PIPERAZIN-1-YL)PYRROLIDIN-2-YL)(1,3-THIAZOLIDIN-3-YL)METHANONE|NCGC00378896-03|3-{(2S,4S)-4-[4-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)PIPERAZIN-1-YL]PYRROLIDIN-2-YLCARBONYL}THIAZOLIDINE|((2S,4S)-4-(4-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)PIPERAZIN-1-YL)PYRROLIDIN-2-YL)(THIAZOLIDIN-3-YL)METHANONE|AS-83281|CS-0882|TENELIGLIPTIN [WHO-DD]|AC-27649|TENELIGLIPTIN (INN)|760937-92-6|TENELI|TENELIGLIPTIN [MI]|[(2S,4S)-4-[4-(5-METHYL-2-PHENYLPYRAZOL-3-YL)PIPERAZIN-1-YL]PYRROLIDIN-2-YL]-(1,3-THIAZOLIDIN-3-YL)METHANONE|AKOS025401965|D08616|AMY40806|MFCD13195565|WGRQANOPCQRCME-PMACEKPBSA-N|HY-14806|M51|NCGC00378896-04|28ZHI4CF9C|906093-29-6|TELIGLIETIN|DB11950|TENELIGLIPTIN|MP-513|((2S,4S)-4-(4-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)PIPERAZIN-1-YL)PYRROLIDIN-2-YL)(THIAZOLIDIN-3-YL)METHANONE HYDROBROMIDE|NCGC00378896-02|GTPL9906|TENELIGLIPTIN  (CONTAIN AROUND 5% HEXANES)|DTXSID30997419|{(2S,4S)-4-[4-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)PIPERAZIN-1-YL]PYRROLIDIN-2-YL}(1,3-THIAZOLIDIN-3-YL)METHANONE|MP513|UNII-28ZHI4CF9C|COMPOUND 8G [PMID: 22959556]|TENELIGLIPTIN [INN]|{4-[4-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)PIPERAZIN-1-YL]PYRROLIDIN-2-YL}(1,3-THIAZOLIDIN-3-YL)METHANONE	-	PUBCHEM	11949652	C22H30N6OS	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	WGRQANOPCQRCME-PMACEKPBSA-N
33337	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Bojkova D (2023)	36644320	239397	10266	EIDD-1931	EIDD-1931|N-Hydroxycytidine|Cytidine, N-hydroxy-|Uridine, 4-oxime|N4-Hydroxycytidine	-	CHEMSPIDER	170635	C9H13N3O6	small molecule	-	3258-02-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor	XCUAIINAJCDIPM-XVFCMESISA-N
33359	4383845	43740570	GU280_gp04	E	env|envelope|SARS-CoV2 E|E protein|emp|SARS-CoV-2 E|VEMP_SARS2|PRO_0000449651	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Ewart G (2023)	37549173	241436	10240	BIT225	BIT-225|N-(Aminoiminomethyl)-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthalenecarboxamide|N-(Diaminomethylene)-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide|2-Naphthalenecarboxamide, N-(diaminomethylene)-5-(1-methyl-1H-pyrazol-4-yl)-	-	CHEMSPIDER	10176885	C16H15N5O	small molecule	-	917909-71-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: E inhibitor, mechanism undetermined; in vivo inhibition of E-protein ion channels in Xenopus oocytes; antiviral activity against SARS-CoV-2 Wuhan-Hu-1, Delta, Omicron, BR, SA, and UK strains in cells; antiviral activity in mouse models	WVROWPPEIMRGAB-UHFFFAOYSA-N
33363	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Yang C (2020)	33024075	241855	10215	Salvianolic acid C	Salvianolic Acid C|(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl}oxy)propanoic acid|Benzenepropanoic acid, alpha-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (alphaR)-|(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2-propenoyl}oxy)propanoic acid|(R,E)-3-(3,4-dihydroxyphenyl)-2-((3-(2-(3,4-dihydroxyphenyl)-7-hydroxybenzofuran-4-yl)acryloyl)oxy)propanoic acid	-	CHEMSPIDER	24534179	C26H20O10	small molecule	-	115841-09-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike inhibitor; S binding (experimental) and disruption of S protein core 6-HB formation; antiviral activity against SARS-CoV-2 Wuhan-Hu-1	GCJWPRRNLSHTRY-VURDRKPISA-N
33364	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Guo C (2023)	36985506	242021	4588	Suramin	Belganyl|Suramin|8,8'-[CARBONYLBIS[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid|Suramine|Naganol|Naphuride	-	DRUGBANK	DB04786	C51H40N6O23S6	small molecule	P01CX02	145-63-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N protein-RNA interaction inhibitor; N binding (experimental)	FIAFUQMPZJWCLV-UHFFFAOYSA-N
33365	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Liu H (2020)	33242394	242032	10313	COVA1-16	-	-	PUBCHEM	440964525	-	antibody	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: S protein inhibitor; S binding (experimental); antiviral activity against SARS-CoV-2 (Frankfurt 1 and USA/CA-CZB-1072/2020) (see also PMID 32540902)	-
33366	4383915	1489668	SARS-CoV-2	S	ORF2|2|spike glycoprotein|E2|surface|S protein|SARS-CoV S|SARS-CoV Spike|peplomer|SPIKE_CVHSA|PRO_0000037208	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov inhibitor	target	Liu H (2020)	33242394	242032	10313	COVA1-16	-	-	PUBCHEM	440964525	-	antibody	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: S protein inhibitor;  S binding (experimental)	-
33367	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Cicka D (2023)	36921991	242054	10216	gossypol acetate	Gossypol Acetic Acid|GOSSYPOL ACETIC ACID, (R)-|MFCD00058385|(+/-)-Gossypol-acetic acid|MD7360000|[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, compd. with acetic acid (1:1)|1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde - acetic acid (1:1)	-	CHEMSPIDER	197885	C32H34O10	small molecule	-	866541-93-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: S-TMPRSS2 interaction inhibitor, S binding (experimental)	NIOHNDKHQHVLKA-UHFFFAOYSA-N
33368	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Cicka D (2023)	36921991	242054	452	Verteporfin	Verteporfina|Verteporfinum|Vertporfine|Verteporfin	visudyne	DRUGBANK	DB00460	C41H42N4O8	small molecule	S01LA01	129497-78-5	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: S-TMPRSS2 interaction inhibitor, S binding (experimental)	YTZALCGQUPRCGW-MXVXOLGGSA-N
33369	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Cicka D (2023)	36921991	242054	10222	Eltrombopag Olamine	Eltrombopag olamine|UNII-4U07F515LG|4U07F515LG|3'-{(2Z)-2-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid - 2-aminoethanol (1:2)|[1,1'-Biphenyl]-3-carboxylic acid, 3'-[(2Z)-2-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-, compd. with 2-aminoethanol (1:2)|Revolade|Promacta	-	CHEMSPIDER	28475107	C29H36N6O6	small molecule	-	496775-62-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: S-TMPRSS2 interaction inhibitor, S binding (experimental)	PLILLUUXAVKBPY-SBIAVEDLSA-N
33371	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Lockbaum GJ (2021)	33503819	242922	10250	ML188	N-{2-[(2-Methyl-2-propanyl)amino]-2-oxo-1-(3-pyridinyl)ethyl}-N-[4-(2-methyl-2-propanyl)phenyl]-2-furamide|3-Pyridineacetamide, N-(1,1-dimethylethyl)-alpha-[[4-(1,1-dimethylethyl)phenyl](2-furanylcarbonyl)amino]-	-	CHEMSPIDER	29394795	C26H31N3O3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Mpro/nsp5 inhibitor; nsp5 binding (experimental); in vitro inhibition	JXGIYKRRPGCLFV-UHFFFAOYSA-N
33372	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Jacobs J (2013)	23231439	242927	10250	ML188	N-{2-[(2-Methyl-2-propanyl)amino]-2-oxo-1-(3-pyridinyl)ethyl}-N-[4-(2-methyl-2-propanyl)phenyl]-2-furamide|3-Pyridineacetamide, N-(1,1-dimethylethyl)-alpha-[[4-(1,1-dimethylethyl)phenyl](2-furanylcarbonyl)amino]-	-	CHEMSPIDER	29394795	C26H31N3O3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: 3CLpro/nsp5 inhibitor; nsp5 binding (experimental); in vitro inhibition; antiviral activity against SARS-CoV Urbani isolate	JXGIYKRRPGCLFV-UHFFFAOYSA-N
33373	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Shannon A (2022)	35110538	243303	10314	AT-9010 (tetrasodium)	CS-0181237|PD164890|HY-139165A|AT-9010 TETRASODIUM|AT-9010 (TETRASODIUM)	-	PUBCHEM	162642756	C11H13FN5Na4O13P3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: nsp12 inhibitor; nsp12 binding (experimental); in vitro inhibition	YSFIWHKJCYGPPP-ZJECJYFYSA-J
33374	4383949	1489680	SARS-CoV-1ab-nsp12ab	nsp12ab	nsp12|sars1ab|orf1ab|SARS-CoV nsp12ab|SARS-CoV nsp12|SARS-CoV sars1ab|orf1ab-nsp12|orf1ab-nsp12ab|pp1ab|RNA-directed RNA polymerase|Pol|RdRp|R1AB_CVHSA|PRO_0000037318	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Shannon A (2022)	35110538	243303	10314	AT-9010 (tetrasodium)	CS-0181237|PD164890|HY-139165A|AT-9010 TETRASODIUM|AT-9010 (TETRASODIUM)	-	PUBCHEM	162642756	C11H13FN5Na4O13P3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: nsp12 inhibitor; in vitro inhibition	YSFIWHKJCYGPPP-ZJECJYFYSA-J
33375	4383864	43740578	GU280_gp01_nsp16	nsp16	ORF1ab|ORF1ab-nsp16|SARS-CoV2 nsp16|SARS-CoV-2 nsp16|2-O-methyltransferase|R1AB_SARS2|PRO_0000449633	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Klima M (2022)	36040262	243275	10315	(2~{s})-2-Azanyl-4-[[(2~{s},3~{s},4~{r},5~{r})-5-(4-Azanyl-5-Cyano-Pyrrolo[2,3-D]pyrimidin-7-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylsulfanyl]butanoic Acid	S-(((2S,3S,4R,5R)-5-(4-AMINO-5-CYANO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL)-L-HOMOCYSTEINE|(2~{S})-2-AZANYL-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-AZANYL-5-CYANO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYLSULFANYL]BUTANOIC ACID|6NR|GLXC-26167|SS148|1985669-27-9|Q27456478	-	PUBCHEM	121225442	C16H20N6O5S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: nsp16 inhibitor; nsp16 binding (experimental); in vitro inhibition	XLTWYAYAFLGUEQ-OPYVMVOTSA-N
33377	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Noske GD (2023)	36941262	243590	10316	MAT-POS-e194df51-1	KG9|MAT-POS-E194DF51-1|(4S)-6-CHLORO-2-[(1-CYANOCYCLOPROPYL)METHANESULFONYL]-N-(ISOQUINOLIN-4-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDE	-	PUBCHEM	156906151	C24H21ClN4O3S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	YAYDSAMHSQCKIM-OAQYLSRUSA-N
33378	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Dai W (2022)	33872498	243632	9982	MPro Inhibitor 11a	1H-Indole-2-carboxamide, N-[(1S)-1-(cyclohexylmethyl)-2-[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]-2-oxoethyl]-|MPro Inhibitor 11a|N-[(2S)-3-Cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxo-3-pyrrolidinyl]-2-propanyl}amino)-2-propanyl]-1H-indole-2-carboxamide|Bofutrelvir	-	CHEMSPIDER	88294718	C25H32N4O4	small molecule	-	2103278-86-8	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	HPKJGHVHQWJOOT-ZJOUEHCJSA-N
33379	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Wang Q (2023)	36844485	243597	10317	7-(6-Nitro-2,3-dihydroindol-1-yl)-7-oxidanylidene-heptanoic acid	Q83|7-(6-NITRO-2,3-DIHYDROINDOL-1-YL)-7-OXIDANYLIDENE-HEPTANOIC ACID	-	PUBCHEM	167311807	C15H18N2O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor; Omicron BA.4	YZWRRAZXWGNXFP-UHFFFAOYSA-N
33380	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Toelzer C (2020)	32958580	239998	10318	Linoleic Acid	CIS,CIS,9,12-OCTADECADIENOIC ACID|HSDB 5200|LINOLEIC ACID, PURE|CIS-D9,12-OCTADECADIENOIC ACID|LINOLEIC ACID, LIQUID, BIOREAGENT, SUITABLE FOR CELL CULTURE|LINOLEIC ACID, TECHNICAL, 60-74% (GC)|9KJL21T0QJ|HMS3886F05|EN300-383983|UNIFAC 6550|9-(Z), 12-(Z)-OCTADECADIENOIC ACID|9-CIS,12-CIS-OCTADECADIENOATE|(9Z,12Z)-OCTADECA-9,12-DIENOIC ACID|C18:2, N-6,9 ALL-CIS|ALL-CIS-9,12-OCTADECADIENOIC ACID|EINECS 200-470-9|60-33-3|LINOLEIC ACID [HSDB]|C18:2|9,12-LINOLEIC ACID|LINOLEIC ACID (MART.)|DTXCID505505|9,12-OCTADECADIENOIC ACID (9Z,12Z)-|9,12-OCTADECADIENOIC ACID, (E,E)-|LINOLEIC ACID (CONSTITUENT OF BORAGE SEED OIL)|NSC281243|UNII-9KJL21T0QJ|TELFAIRIC ACID|CIS-.DELTA.9,12-OCTADECADIENOIC ACID|LINOLEIC ACID, >=93% (GC)|ACON1_000270|DELTA9,12-OCTADECADIENOIC ACID|SR-01000944790-1|A832696|EXTRA LINOLEIC 90|CIS,12-OCTADECADIENOIC ACID|POLYLIN NO 515|BML3-C03|HMS1791E16|FATTY ACID 18:2 N-6|9-CIS,12-CIS-OCTADECADIENOIC ACID|LIN|(9Z,12Z)-9,12-OCTADECADIENOIC ACID|CCRIS 652|LINOLEIC ACID (CONSTITUENT OF SAW PALMETTO)|CIS-DELTA9,12-OCTADECADIENOIC ACID|30175-49-6|14C-LINOLEIC ACID|LINOLEIC ACID (CONSTITUENT OF SPIRULINA)|NCGC00091049-03|CIS,CIS-OCTADECA-9,12-DIENOIC ACID|NCGC00259720-01|BMSE000497|AKOS015951293|LEINOLEIC ACID|CIS,CIS-9,12-OCTADECADIENOIC ACID|ALL-CIS-9,12-OCTADECADIENOATE|ALPHA-LINOLEIC ACID|LINOLEIC ACID (CONSTITUENT OF FLAX SEED OIL)|BP-31121|CS-0009742|LINOLEIC ACID, >=95%, FG|C18:2 9C, 12C OMEGA6 TODOS CIS-9,12-OCTADIENOICO|LINOLEIC ACID [MI]|C18:2 9C|LINOLEIC ACID, 95%|12C OMEGA6 TODOS CIS-9,12-OCTADIENOICO|LINOLEIC ACID [VANDF]|NSC 281243|CIS-D9,12-OCTADECADIENOATE|OCTADECA-9,12-DIENOIC ACID, (CIS,CIS)-|LINOLEIC ACID (C18:2) (CONSTITUENT OF KRILL OIL)|9-CIS,12-CIS-LINOLEIC ACID|(Z,Z)-OCTADECA-9, 12-DIENOIC ACID|NCGC00091049-05|9,12-OCTADECADIENOIC ACID, (Z,Z)-, LABELED WITH CARBON-14|(14C)ALPHA-LINOLENIC ACID|AC-33770|HMS3649F07|LINOLEIC ACID (CONSTITUENT OF SPIRULINA) [DSC]|EMERSOL 310|C18:2 (N-6)|(9Z,12Z)-9,12-OCTADECADIENOATE|9,12-OCTADECADIENOIC ACID, (Z)-|HMS1361E16|IDI1_033844|RONACARE ASC 3|(9Z,12Z)-OCTADECADIENOIC ACID|9,12-OCTADECADIENOIC ACID|CIS,CIS-LINOLEATE|NCGC00091049-06|L0124|OCTADECA-9,12-DIENOIC ACID|9,12-OCTADECADIENOIC ACID (Z,Z)-|80969-37-5|(Z)-9,12-OCTADECADIENOIC ACID|9Z,12Z-OCTADECADIENOIC ACID|LINOLEIC ACID|NSC-281243|FEMA NO. 3380, LINOLEIC ACID-|HMS1989E16|CIS-DELTA(9,12)-OCTADECADIENOIC ACID|(14C)-LINOLEIC ACID|LINOLEIC ACID [WHO-DD]|NCGC00091049-01|LINOLEIC ACID [MART.]|LINOLIC ACID|(Z,Z)-9,12-OCTADECADIENOIC ACID|LMFA01030120|ACID, 9,12-OCTADECADIENOIC|LINOLEIC ACID, ANALYTICAL STANDARD|CIS-9,CIS-12-OCTADECADIENOATE|C01595|SR-01000944790-3|CIS, CIS-OCTADECA-9,12-DIENOIC ACID|BMSE000604|9,12-OCTADECADIENOIC ACID, (Z,Z)-|NCGC00091049-02|LINOLEIC-ACID|Q407426|BRD-K08973992-001-03-9|TOX21_111067|N-6,9 ALL-CIS|8016-21-5|CIS-9,CIS-12-OCTADECADIENOIC ACID,|9,12 OCTADECADIENOIC ACID|8024-22-4|CIS-9, CIS-12-OCTADECADIENOIC ACID|LEINOLIC ACID|ACIDO LINOLEICO|9,12-OCTADECADIENOIC ACID (VAN)|VESPULA PENSYLVANICA B708568K063|AI3-11132|CIS-9,CIS-12-OCTADECADIENOIC ACID|LINOLEIC ACID, >=99%|(9Z,12Z)-9,12-OCTADECADIENOIC-1-13C ACID|AS-12672|DB14104|LINOLEIC ACID, PURISS., 90%|5CE5E1F3-8859-4C5B-9AFE-E44A7076DF6E|SR-01000944790|DTXSID2025505|ACIDELINOLEIQUE|9Z,12Z-LINOLEIC ACID|L0053|9Z,12Z-OCTADECADIENOATE|POLYIN NO.515|UNII-7552P0K6PN|HMS3402E16|NCGC00257024-01|TRANS-9,TRANS-12-OCTADECADIENOIC ACID|LINOLEIC ACID, 2.0 MG/ML IN ETHANOL, CERTIFIED REFERENCE MATERIAL|7552P0K6PN|HY-N0729|9Z,12Z-LINOLEATE|CIS,CIS-9,12-OCTADECADIENOIC ACID; LINOLEATE; EMERSOL315; LINOLEIC; UNIFAC6550;|CCRIS 650|EMERSOL 315|LINOLEIC|NCGC00091049-04|AI3-36448|9,12-OCTADECADIENOIC ACID, CIS,CIS-|PAMOLYN 125 (SALT/MIX)|TOX21_202171|LINOLEIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC]|LINOLEATE|MFCD00064241|NCGC00091049-07|(Z,Z)-9,12-OCTADECADIENOATE|9, (Z)-|LINOLEIC ACID [INCI]|S5821|FA(18:2(9Z,12Z))|LINOLEIC ACID, >=95%|EPITOPE ID:117705|LINOLATE|9-CIS,12-CIS-LINOLEATE|VITAMIN F COMPONENT LINOLEIC ACID|ACIDE LINOLEIQUE|CIS,CIS-LINOLEIC ACID|BSPBIO_001374|85594-37-2|9,Z)-|TOX21_303080|GTPL1052|ACIDE CIS-LINOLEIQUE|LINOLEIC ACID [FCC]	-	PUBCHEM	5280450	C18H32O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Binds Spike protein, possible modification of Spike-Ace2 interaction, synergizes with remdesivir	OYHQOLUKZRVURQ-HZJYTTRNSA-N
33381	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Staufer O (2022)	35165285	246072	4052	Oleic Acid	-	sha-lem	DRUGBANK	DB04224	C18H34O2	small molecule	-	112-80-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, additional ref: 33692215	ZQPPMHVWECSIRJ-MDZDMXLPSA-N
33382	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Tong L (2022)	35862773	246234	745	Tretinoin	ATRA|Tretinoin|Tretinoine (french) (einecs)|Retin-a|all-trans-beta-Retinoic acid|All Trans-Retinoic Acid|Trtinone|All Trans Retinoic Acid|Solage|3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ecl)|Retionic Acid|trans-Retinoic acid|all-trans-Retinoic acid|RETINOIC acid|Retisol-a|Vesanoid|Ro 1-5488|Vitinoin|Renova|AGN 100335|Vitamin A acid|(all-e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid|all-trans-Tretinoin|Tretin m|beta-Retinoic acid|all-(e)-Retinoic acid|Stieva-a|Tretinoina|Tretinoinum|all-trans-Vitamin a1 acid|Eudyna|all-trans-Vitamin a acid|Acide retinoique (french) (dsl)	tretinoin gel microsphere|viti	DRUGBANK	DB00755	C20H28O2	small molecule	L01XX14|D10AD01|D10AD51	302-79-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor	SHGAZHPCJJPHSC-YCNIQYBTSA-N
33383	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Tan B (2023)	36580641	243374	10319	benzyl (3S,3aS,6aR)-3-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate	UAWJ9-36-1|PD195025	-	PUBCHEM	156596252	C23H29N3O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	XXWDDQJFYNJUCB-HVTWWXFQSA-N
33384	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Tan B (2023)	36580641	243374	10320	CID 155818902	UAWJ9-36-3|BENZYL (1R,2S,5S)-2-[[(2S)-1-HYDROXY-3-[(3S)-2-OXOPYRROLIDIN-3-YL]PROPAN-2-YL]CARBAMOYL]-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLATE|BENZYL (1R,2S,5S)-2-({(2S)-1-HYDROXY-3-[(3S)-2-OXOPYRROLIDIN-3-YL]PROPAN-2-YL}CARBAMOYL)-6,6-DIMETHYL-3-AZABICYCLO[3.1.0]HEXANE-3-CARBOXYLATE|GTPL11701	-	PUBCHEM	155818902	C23H31N3O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	KXNVRILCTPCDNL-VMXHOPILSA-N
33385	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Tan B (2023)	36580641	243374	10321	Sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)-1-hydroxy-3-((S)-2-oxopyrrolidin-3-yl)propane-1-sulfonate	UAWJ247|1802664-84-1|GLXC-26538|SODIUM (2S)-2-((S)-2-(((BENZYLOXY)CARBONYL)AMINO)-3-PHENYLPROPANAMIDO)-1-HYDROXY-3-((S)-2-OXOPYRROLIDIN-3-YL)PROPANE-1-SULFONATE	-	PUBCHEM	167312260	C24H28N3NaO8S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	VFYODHDNARQKEF-SJZJPLIYSA-M
33386	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Tan B (2023)	36580641	243374	10322	2-(N-(2-chloroacetyl)-4-phenylanilino)-N-[(1S)-1-phenylethyl]-2-pyridin-3-ylacetamide	JUN9-54-1	-	PUBCHEM	162396332	C29H26ClN3O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	XQECDPKLDAEYEC-QDLLFRBVSA-N
33387	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Tan B (2023)	36580641	243374	10323	(2R)-2-(N-(2,2-dichloroacetyl)-4-phenylanilino)-N-[(1S)-1-phenylethyl]-2-pyridin-3-ylacetamide	JUN9-62-2R|PD193964	-	PUBCHEM	162396343	C29H25Cl2N3O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	LEOCNIZCHQOMFL-RXFWQSSRSA-N
33388	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Qiao J (2021)	33602867	246235	10324	CID 155803069	(1R,2R,5S)-6,6-DIMETHYL-N-[(2S)-1-OXO-3-[(3S)-2-OXOPYRROLIDIN-3-YL]PROPAN-2-YL]-3-[2-[4-(TRIFLUOROMETHOXY)PHENOXY]ACETYL]-3-AZABICYCLO[3.1.0]HEXANE-2-CARBOXAMIDE|MI-09|GLXC-25594|MI09	-	PUBCHEM	155803069	C24H28F3N3O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	RBWMYPKAPIYTJQ-DEGWKOFMSA-N
33389	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Qiao J (2021)	33602867	246235	10325	(3S,3aS,6aR)-2-[3-(3,5-difluorophenyl)propanoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide	GLXC-26317|COMPOUND 18I [PMID: 33602867]|MI23|(1S,3AR,6AS)-2-(3-(3,5-DIFLUOROPHENYL)PROPANOYL)-N-((S)-1-OXO-3-((S)-2-OXOPYRROLIDIN-3-YL)PROPAN-2-YL)OCTAHYDROCYCLOPENTA[C]PYRROLE-1-CARBOXAMIDE|GTPL11432|MI-23	-	PUBCHEM	155804440	C24H29F2N3O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	ZUAZJPLYYVHKFN-NAFADOBPSA-N
33390	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Qiao J (2021)	33602867	246235	10326	CID 155803090	GLXC-25593|MI-30|MI30|(3R,3AR,6AR)-2-[2-(2,4-DICHLOROPHENOXY)ACETYL]-N-[(2S)-1-OXO-3-[(3S)-2-OXOPYRROLIDIN-3-YL]PROPAN-2-YL]-3,3A,4,5,6,6A-HEXAHYDRO-1H-CYCLOPENTA[C]PYRROLE-3-CARBOXAMIDE	-	PUBCHEM	155803090	C23H27Cl2N3O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	HKJKOHDJUKCNRG-IEBLYUSBSA-N
33391	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Li J (2022)	35809383	243373	10231	PF-07304814	1H-Indole-2-carboxamide, 4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]-|(3S)-3-({N-[(4-Methoxy-1H-indol-2-yl)carbonyl]-L-leucyl}amino)-2-oxo-4-[(3S)-2-oxo-3-pyrrolidinyl]butyl dihydrogen phosphate	-	CHEMSPIDER	114935506	C24H33N4O9P	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	FQKALOFOWPDTED-WBAXXEDZSA-N
33392	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Li J (2022)	35809383	243373	10231	PF-07304814	1H-Indole-2-carboxamide, 4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]-|(3S)-3-({N-[(4-Methoxy-1H-indol-2-yl)carbonyl]-L-leucyl}amino)-2-oxo-4-[(3S)-2-oxo-3-pyrrolidinyl]butyl dihydrogen phosphate	-	CHEMSPIDER	114935506	C24H33N4O9P	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	FQKALOFOWPDTED-WBAXXEDZSA-N
33393	4383890	14254602	G128_gp01ab_nsp5	nsp5ab	ORF1ab|nsp5|rep|1AB|MERS-CoV nsp5|orf1ab-nsp5|orf1ab-nsp5ab|nsp5ab|3C-like proteinase|R1AB_CVEMC|PRO_0000422443	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor	target	Li J (2022)	35809383	243373	10231	PF-07304814	1H-Indole-2-carboxamide, 4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]-|(3S)-3-({N-[(4-Methoxy-1H-indol-2-yl)carbonyl]-L-leucyl}amino)-2-oxo-4-[(3S)-2-oxo-3-pyrrolidinyl]butyl dihydrogen phosphate	-	CHEMSPIDER	114935506	C24H33N4O9P	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	FQKALOFOWPDTED-WBAXXEDZSA-N
33398	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Mercaldi GF (2022)	36323732	244096	10168	CA/chicoric acid	(2R,3R)-2,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}succinic acid|(2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid|L-Cichoric acid|2,3-Dicaffeoyl-L-tartaric acid|(2R,3R)-2,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy}butanedioic acid|2,3-Di-trans-caffeoyltartaric acid|MFCD22683653|S4YY3V8YHD|( -)-Chicoric acid|2R,3R-O-dicaffeoyltartaric acid|Butanedioic acid, 2,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-, (2R,3R)-|Dicaffeoyl-L-tartaric acid|Chicoric acid, (-)-|(-)-L-Chicoric acid|(-)-Chicoric acid|Cichoric acid|Chicoric acid|(2R,3R)-2,3-Bis{[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oxy}succinic acid	-	CHEMSPIDER	4445078	C22H18O12	small molecule	-	6537-80-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral N-RNA interaction inhibitor; N binding (experimental); antiviral activity against SARS-CoV-2/SP02/human/2020/BRA	YDDGKXBLOXEEMN-IABMMNSOSA-N
33399	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Saxena U (2023)	888800000968	243898	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor	XZWYZXLIPXDOLR-UHFFFAOYSA-N
33400	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Saxena S (2021)	888800000281	228565	4665	Omacetaxine mepesuccinate	()-homoharringtonine|Homoharringtonin|(2'R,3S,4S,5R)-()-homoharringtonine|Homoharringtonine|HHT	synribo	DRUGBANK	DB04865	C29H39NO9	small molecule	L01XX40	26833-87-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor; S binding (computational); antiviral activity against SARS-CoV-2 in Vero E6 cells (cites PMID: 32251767 )	HYFHYPWGAURHIV-JFIAXGOJSA-N
33401	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Yamaoka Y (2022)	35891441	244390	10230	Soyasaponin I	(3beta,22beta)-22,24-Dihydroxyolean-12-en-3-yl 6-deoxy-alpha-L-mannopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucopyranosiduronic acid|beta-D-Glucopyranosiduronic acid, (3beta,22beta)-22,24-dihydroxyolean-12-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-beta-D-galactopyranosyl-(1->2)-|soyasaponin 1|Soyasaponin-Bb|Soyasaponin Bb|Soyasaponin I	-	CHEMSPIDER	108898	C48H78O18	small molecule	-	51330-27-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor; S binding (experimental); antiviral activity against SARS-CoV-2 Wuhan, Delta, Omicron BA.1 and Omicron BA.2	PTDAHAWQAGSZDD-IOVCITQVSA-N
33402	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Chen Y (2022)	36468859	246236	1092	Sertraline	cis-(+)-Sertraline|Sertraline|(+)-Sertraline|Sertralina|(1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine|(1S,4S)-Sertraline|CP 51974|Sertralinum	ipg-sertraline|sertraline|nu-s	DRUGBANK	DB01104	C17H17Cl2N	small molecule	N06AB06	79617-96-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor; S binding; antiviral activity against SARS-CoV-2 in Vero E6 cells	VGKDLMBJGBXTGI-SJCJKPOMSA-N
33403	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zhao Y (2021)	33864621	246237	10208	Sepantronium Bromide	Sepantronium bromide|1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide|4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, bromide (1:1)|YM-155|7H5Q4J1CM5|1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1)|1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide	-	CHEMSPIDER	9353328	C20H19BrN4O3	small molecule	-	781661-94-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	QBIYUDDJPRGKNJ-UHFFFAOYSA-M
33404	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zhao Y (2021)	33864621	246237	10235	cryptotanshinone	(1R)-1,6,6-Trimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione|Tanshinone C|SF8282645|MFCD07636810|1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione|(R)-(-)-1,6,6-Trimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione|Cryptotanshinon|Phenanthro[1,2-b]furan-10,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (1R)-|Phenanthro(1,2-b)furan-10,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (R)-|Cryptotanshinone	-	CHEMSPIDER	140851	C19H20O3	small molecule	-	35825-57-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	GVKKJJOMQCNPGB-JTQLQIEISA-N
33405	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zhao Y (2021)	33864621	246237	10327	Tanshinone I	MLS006011773|1,6-DIMETHYL-10H,11H-PHENANTHRO[1,2-B]FURAN-10,11-DIONE|1,6-DIMETHYLPHENANTHRO[1,2-B]FURAN-10,11-DIONE|NCGC00247624-01|568-73-0|AIGAZQPHXLWMOJ-UHFFFAOYSA-|SMR000445578|AC-7999|FT-0632407|Q27247588|03UUH3J385|NCGC00247624-02|TANSHINONE I, >=98% (HPLC)|NCGC00247624-03|1,6-DIMETHYL-PHENANTHRO(1,2-B)FURAN-10,11-DIONE|1,6-DIMETHYLNAPHTHO[1,2-G][1]BENZOFURAN-10,11-DIONE|Q-100655|C18H12O3|TANSHINONE I, ANALYTICAL STANDARD|S2364|CID_114917|TANSHINONE A|A831218|PHENANTHRO[1,2-B]FURAN-10,11-DIONE, 1,6-DIMETHYL-|AKOS005613012|1,6-DIMETHYLPHENANTHRO(1,2-B)FURAN-10,11-DIONE|TANSHINONE I (CONSTITUENT OF CHINESE SALVIA) [DSC]|HMS2222J14|UNII-03UUH3J385|1,6-DIMETHYL-PHENANTHRO[1,2-B]FURAN-10,11-DIONE|CCG-267206|SW219821-1|TANSHINONEI|TANSHINONE-I|MLS000697676|TANSHINON I, TANSHINONE A, TANSHINQUINONE I|1,6-DIMETHYLPHENANTHRO[1,2-B]FURAN-10,11-DIONE #|INCHI=1/C18H12O3/C1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/H3-8H,1-2H3|1,6-DIMETHYLNAPHTHO[1,2-G]BENZOFURAN-10,11-DIONE|TANSHINONE|DTXSID90972247|1,6-DIMETHYLNAPHTHO[1,2-G]BENZOFURAN-10,11-QUINONE|HMS3656A11|54693-68-4|TANSHINON I|PHENANTHRO(1,2-B)FURAN-10,11-DIONE, 1,6-DIMETHYL-|TANSHINONE I,(S)|TANSHINONE I (CONSTITUENT OF CHINESE SALVIA)|TANSHINONE I|HY-N0134|MFCD00210563|AS-68049|NCGC00247624-05|TRISTEARYLORTHOFORMATE|BCP28292	-	PUBCHEM	114917	C18H12O3	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	AIGAZQPHXLWMOJ-UHFFFAOYSA-N
33406	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zhao Y (2021)	33864621	246237	7430	GRL0617	5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide	-	DRUGBANK	DB08656	C20H20N2O	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: PLPro inhibitor	UVERBUNNCOKGNZ-CQSZACIVSA-N
33407	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Panagiotopoulos A (2021)	34128351	245325	10283	P-CYMENE	p-isopropyltoluene|p-cymene|p-methylcumene|p-methyl cumene|para-cymene|4-Isopropyltoluene|4-cymene|Cumene, p-methyl-|Cymene|Cymene, p-|1-Isopropyl-4-methylbenzene|4-methyl isopropylbenzene|Benzene, 1-methyl-4-(1-methylethyl)-|4-methyl-1-(propan-2-yl)benzene|Benzene, 1-methyl-4- (1-methylethyl)-|p-methyl-Cumene|1-isopropyl-4-methyl-Benzene|1-Methyl-4-(1-methylethyl)-benzene|p-Mentha-1,3,5-triene|1903377|1-methyl-4-(propan-2-yl)benzene|MFCD00008893|1G1C8T1N7Q|4V31KQF934	-	CHEMSPIDER	7183	C10H14	small molecule	-	13816-33-6	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: predicted nucleocapsid (N) protein interactor with demonstrated anti-SARS-CoV-2 plaque formation and titer properties	HFPZCAJZSCWRBC-UHFFFAOYSA-N
33408	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Martinez DR (2023)	888800000993	244293	10205	ATV006	[(2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methyl 2-methylpropanoate (non-preferred name)	-	CHEMSPIDER	115037299	C16H19N5O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor; antiviral activity against SARS-CoV-2 WA/1 and SARS-CoV-2 BA.1 Omicron variant in A549-hACE2 cells and mice	YIHPGVCWGSURHO-VSBTWAGUSA-N
33409	4383949	1489680	SARS-CoV-1ab-nsp12ab	nsp12ab	nsp12|sars1ab|orf1ab|SARS-CoV nsp12ab|SARS-CoV nsp12|SARS-CoV sars1ab|orf1ab-nsp12|orf1ab-nsp12ab|pp1ab|RNA-directed RNA polymerase|Pol|RdRp|R1AB_CVHSA|PRO_0000037318	694009	Severe acute respiratory syndrome-related coronavirus	sars-cov inhibitor	target	Martinez DR (2023)	888800000993	244293	10205	ATV006	[(2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methyl 2-methylpropanoate (non-preferred name)	-	CHEMSPIDER	115037299	C16H19N5O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: RdRp inhibitor; antiviral activity against SARS-CoV in A549-hACE2 cells and mice	YIHPGVCWGSURHO-VSBTWAGUSA-N
33410	4383896	14254602	G128_gp01ab_nsp12	nsp12ab	ORF1ab|nsp12|rep|1AB|MERS-CoV nsp12|orf1ab-nsp12|orf1ab-nsp12ab|nsp12ab|RNA polymerase|R1AB_CVEMC|PRO_0000422449	1335626	Middle-East Respiratory Syndrome-related Coronavirus	mers-cov inhibitor	target	Martinez DR (2023)	888800000993	244293	10205	ATV006	[(2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methyl 2-methylpropanoate (non-preferred name)	-	CHEMSPIDER	115037299	C16H19N5O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: RdRp inhibitor; antiviral activity against MERS-CoV in A549-hACE2 cells and mice	YIHPGVCWGSURHO-VSBTWAGUSA-N
33411	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Yotsuyanagi H (2024)	38335000	244291	9978	Ensitrelvir	1,3,5-Triazine-2,4(1H,3H)-dione, 6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]dihydro-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-, (6E)-|(6E)-6-[(6-Chloro-2-methyl-2H-indazol-5-yl)imino]-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-(2,4,5-trifluorobenzyl)-1,3,5-triazinane-2,4-dione	-	CHEMSPIDER	115007411	C22H17ClF3N9O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor; effective in clincial trial against SARS-CoV-2	QMPBBNUOBOFBFS-UHFFFAOYSA-N
33412	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zapata-Cardona MI (2023)	36891537	246238	5646	Raltegravir	MK-0518|RAL	isentress	DRUGBANK	DB06817	C20H21FN6O5	small molecule	J05AR16|J05AX08	518048-05-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor; D614G strain, additional evidence in PMID: 34311539	CZFFBEXEKNGXKS-UHFFFAOYSA-N
33413	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zapata-Cardona MI (2023)	36891537	246238	699	Lamivudine	Lamivudinum|beta-L-3'-Thia-2',3'-dideoxycytidine|beta-L-2',3'-Dideoxy-3'-thiacytidine|2',3'-Dideoxy-3'-thiacytidine|3TC|(-)-2'-Deoxy-3'-thiacytidine|Epivir|3'-Thia-2',3'-dideoxycytidine|Lamivudine|Lamivudin|(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine|Lamivudina	apo-zidovudine-lamivudine-nevi	DRUGBANK	DB00709	C8H11N3O3S	small molecule	J05AF05|J05AR01|J05AR02|J05AR05|J05AR04|J05AR07|J05AR16|J05AR12|J05AR13|J05AR11	134678-17-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor; D614G strain, additional evidence in PMID: 34367956	JTEGQNOMFQHVDC-NKWVEPMBSA-N
33414	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zapata-Cardona MI (2023)	36891537	246238	869	Emtricitabine	(-)-cis-4-amino-5-Fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one|(-)-beta-2',3'-Dideoxy-5-fluoro-3'-thiacytidine|Emtricitabin|4-Amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one|(-)-2'-Deoxy-5-fluoro-3'-thiacytidine|(2R-cis)-4-amino-5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone|Emtricitabina|4-amino-5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one|Emtricitabine|(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine|(-)-FTC|5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine|Emtricitabinum	stribild|truvada|emtriva|odefs	DRUGBANK	DB00879	C8H10FN3O3S	small molecule	J05AR19|J05AF09|J05AR08|J05AR03|J05AR18|J05AR06|J05AR09|J05AR17	143491-57-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor; D614G strain	XQSPYNMVSIKCOC-NTSWFWBYSA-N
33415	4383890	14254602	G128_gp01ab_nsp5	nsp5ab	ORF1ab|nsp5|rep|1AB|MERS-CoV nsp5|orf1ab-nsp5|orf1ab-nsp5ab|nsp5ab|3C-like proteinase|R1AB_CVEMC|PRO_0000422443	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor/mers-cov inhibitor	target	Li J (2022)	35809383	243373	9959	PF-00835231	1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-|N-[(2S)-1-({(2S)-4-Hydroxy-3-oxo-1-[(3S)-2-oxo-3-pyrrolidinyl]-2-butanyl}amino)-4-methyl-1-oxo-2-pentanyl]-4-methoxy-1H-indole-2-carboxamide	-	CHEMSPIDER	9736673	C24H32N4O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	QDIMHKWNHMVDJB-WBAXXEDZSA-N
33416	4383890	14254602	G128_gp01ab_nsp5	nsp5ab	ORF1ab|nsp5|rep|1AB|MERS-CoV nsp5|orf1ab-nsp5|orf1ab-nsp5ab|nsp5ab|3C-like proteinase|R1AB_CVEMC|PRO_0000422443	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor/mers-cov inhibitor	target	Li J (2022)	35809383	243373	9944	GC-376	BCP32603|GC-376; GC 376|GC376|(2S)-1-hydroxy-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate	-	PUBCHEM	146681255	C21H30N3O8S-	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor	-
33420	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Zhong B (2022)	35600064	244624	8359	Oridonin	Oridonin|(1alpha,5beta,6beta,7alpha,8alpha,9beta,10alpha,13alpha,14R)-1,6,7,14-Tetrahydroxy-7,20-epoxykaur-16-en-15-one	-	CHEMSPIDER	23326877	C20H28O6	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV-2 in Vro e6cells	SDHTXBWLVGWJFT-BAFGBBEMSA-N
33421	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Wang Z (2023)	37379907	240920	10242	Aclarubicin	1-naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-(tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)hexopyranosyl]-3-(dimethylamino)hexopyranosyl]oxy]-, methyl ester	-	CHEMSPIDER	1931	C42H53NO15	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: RdRp inhibitor; antiviral activity against SARS-CoV-2 in Calu-3 cells	USZYSDMBJDPRIF-UHFFFAOYSA-N
33422	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Dhaka P (2023)	37956938	240924	7943	Netoglitazone	MCC 555|PGX-510|RWJ-241947	-	DRUGBANK	DB09199	C21H16FNO3S	small molecule	-	161600-01-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding; antiviral activity against SARS-CoV-2 in Vero E6 cells	PKWDZWYVIHVNKS-UHFFFAOYSA-N
33423	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Dhaka P (2023)	37956938	240924	10277	Bictegravir	(1S,11R,13R)-5-Hydroxy-3,6-dioxo-N-(2,4,6-trifluorobenzyl)-12-oxa-2,9-diazatetracyclo[11.2.1.0~2,11~.0~4,9~]hexadeca-4,7-diene-7-carboxamide|2,5-Methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, 2,3,4,5,7,9,13,13a-octahydro-8-hydroxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-, (2R,5S,13aR)-|bictegravir|8GB79LOJ07|UNII:8GB79LOJ07|GS-9883-01|GS-9883|(2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide	-	CHEMSPIDER	44208822	C21H18F3N3O5	small molecule	-	1611493-60-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding; antiviral activity against SARS-CoV-2 in Vero E6 cells	SOLUWJRYJLAZCX-LYOVBCGYSA-N
33424	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Dhaka P (2023)	37956938	240924	10167	ANA-12	N2-(2-{[(2-oxoazepan-3-yl)amino]carbonyl}phenyl)benzo[b]thiophene-2-carboxamide|Benzo[b]thiophene-2-carboxamide, N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-|N-{2-[(2-Oxo-3-azepanyl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide|ANA-12|N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide|N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide|MFCD00117444|ANA 12|N-{2-[(2-OXO-3-AZEPANYL)CARBAMOYL]PHENYL}-1-BENZOTHIOPHENE-2-CARB OXAMIDE|BCP16021|N-[2-[[(HEXAHYDRO-2-OXO-1H-AZEPIN-3-YL)AMINO]CARBONYL]PHENYL]BENZO[B]THIOPHENE-2-CARBOXAMIDE|HY-12497|N-[2-[[(HEXAHYDRO-2-OXO-1H-AZEPIN-3-YL)AMINO]CARBONYL]PHENYL]-BENZO[B]THIOPHENE-2-CARBOXAMIDE|BENZO(B)THIOPHENE-2-CARBOXAMIDE, N-(2-(((HEXAHYDRO-2-OXO-1H-AZEPIN-3-YL)AMINO)CARBONYL)PHENYL)-|S7745|CCG-222404|UNII-54S4JPT8JX|NCGC00379202-06|MAYBRIDGE1_001394|HMS3886N17|N-(2-((2-OXOAZEPAN-3-YL)CARBAMOYL)PHENYL)BENZO[B]THIOPHENE-2-CARBOXAMIDE|219766-25-3|A878840|OPREA1_341312|EX-A815|HMS545H08|54S4JPT8JX|FT-0700267|CS-3616|J-690263|N-{2-[(2-OXOAZEPAN-3-YL)CARBAMOYL]PHENYL}-1-BENZOTHIOPHENE-2-CARBOXAMIDE|DTXSID501045818|ANA-12, >=98% (HPLC)|N-(2-(2-OXOAZEPAN-3-YLCARBAMOYL)PHENYL)BENZO[B]THIOPHENE-2-CARBOXAMIDE|N-[2-[(2-OXOAZEPAN-3-YL)CARBAMOYL]PHENYL]-1-BENZOTHIOPHENE-2-CARBOXAMIDE|AS-16798|ANA-12|AC-32995|N-(2-(((HEXAHYDRO-2-OXO-1H-AZEPIN-3-YL)AMINO)CARBONYL)PHENYL)BENZO(B)THIOPHENE-2-CARBOXAMIDE|MFCD00117444|AKOS024458344|ANA12|NCGC00379202-10	-	CHEMSPIDER	2078460	C22H21N3O3S	small molecule	-	219766-25-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding; antiviral activity against SARS-CoV-2 in Vero E6 cells	TUSCYCAIGRVBMD-UHFFFAOYSA-N
33425	4383847	43740575	GU280_gp10	N	nuc|nucleocapsid|SARS-CoV2 N|N protein|ncap|SARS-CoV-2 N|Nucleoprotein|NCAP_SARS2|PRO_0000449656	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Dhaka P (2023)	37956938	240924	10233	Bisdemethoxycurcumin	Bisdemethoxycurcumin|curcumin III|Bis(p-hydroxycinnamoyl)methane|1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-|1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (E,E)-|(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione|Didemethoxycurcumin|(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione|Bisdesmethoxycurcumin|MFCD03419284|2EFO1BP34R|(E,E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione	-	CHEMSPIDER	4474770	C19H16O4	small molecule	-	33171-05-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: N binding; antiviral activity against SARS-CoV-2 in Vero E6 cells	PREBVFJICNPEKM-YDWXAUTNSA-N
33434	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Teshima K (2023)	36987590	244749	10262	curcumin	diferuloylmethane|(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione|1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-|(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione|(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione|C Yellow 15|trans,trans-Curcumin|Diferulylmethane|Curcumin|CURCUMINE	-	CHEMSPIDER	839564	C21H20O6	small molecule	-	8024-37-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (computational); antiviral activity against SARS-CoV-2 in Vero E6 cells	VFLDPWHFBUODDF-FCXRPNKRSA-N
33435	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Teshima K (2023)	36987590	244749	10237	demethoxycurcumin	demethoxycurcumin|curcumin II|monodemethoxycurcumin|(1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione|Desmethoxycurcumin|(E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione|(1E,6E)-Demethoxycurcumin|MFCD03427310|(1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione|1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E)-|1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-	-	CHEMSPIDER	4579941	C20H18O5	small molecule	-	22608-11-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (computational); antiviral activity against SARS-CoV-2 in Vero E6 cells	HJTVQHVGMGKONQ-LUZURFALSA-N
33436	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Teshima K (2023)	36987590	244749	10233	Bisdemethoxycurcumin	Bisdemethoxycurcumin|curcumin III|Bis(p-hydroxycinnamoyl)methane|1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-|1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (E,E)-|(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione|Didemethoxycurcumin|(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione|Bisdesmethoxycurcumin|MFCD03419284|2EFO1BP34R|(E,E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione	-	CHEMSPIDER	4474770	C19H16O4	small molecule	-	33171-05-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (computational); antiviral activity against SARS-CoV-2 in Vero E6 cells	PREBVFJICNPEKM-YDWXAUTNSA-N
33437	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Teshima K (2023)	36987590	244749	10238	curcumin sulfate	1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-[3-methoxy-4-(sulfooxy)phenyl]-, (1E,6E)-|4-[(1E,6E)-7-(4-Hydroxy-3-methoxyphenyl)-3,5-dioxo-1,6-heptadien-1-yl]-2-methoxyphenyl hydrogen sulfate|CURCUMIN SULFATE	-	CHEMSPIDER	34988878	C21H20O9S	small molecule	-	339286-19-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (computational); antiviral activity against SARS-CoV-2 in Vero E6 cells	NEJVQQBBTRFOHB-FCXRPNKRSA-N
33438	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Passariello M (2022)	35628365	244860	10328	SOTROVIMAB	-	-	PUBCHEM	472422617	-	monoclonal antibody	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (experimental)	-
33439	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Passariello M (2022)	35628365	244860	10171	mulberrofuran G	albanol A|Mulberrofuran G|3aH-Benzo[c][1]benzopyrano[4,3,2-ij][2]benzopyran-4,11-diol, 8a-(2,4-dihydroxyphenyl)-1,8a,13b,13c-tetrahydro-6-(6-hydroxy-2-benzofuranyl)-2-methyl-, (3aR,8aS,13bR,13cS)-|(3aR,8aS,13bR,13cS)-8a-(2,4-Dihydroxyphenyl)-6-(6-hydroxy-1-benzofuran-2-yl)-2-methyl-1,8a,13b,13c-tetrahydro-3aH-benzo[3,4]isochromeno[1,8-bc]chromene-4,11-diol	-	CHEMSPIDER	8135141	C34H26O8	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, S and ACE2 binding (experimental); antiviral activity against SARS-CoV-2 betaCoV/Korea/KCDC03/2020	MJJWBJFYYRAYKU-OPKNDJPNSA-N
33440	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Turlington M (2013)	24080461	243989	10251	ML300	N-{4-[(1H-Benzotriazol-1-ylacetyl)(3-thienylmethyl)amino]phenyl}cyclopropanecarboxamide|1H-1,2,3-Benzotriazole-1-acetamide, N-[4-[(cyclopropylcarbonyl)amino]phenyl]-N-(3-thienylmethyl)-	-	CHEMSPIDER	30840805	C23H21N5O2S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	OCKMJWOFMCSMEX-UHFFFAOYSA-N
33441	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Han SH (2022)	34347470	246239	10251	ML300	N-{4-[(1H-Benzotriazol-1-ylacetyl)(3-thienylmethyl)amino]phenyl}cyclopropanecarboxamide|1H-1,2,3-Benzotriazole-1-acetamide, N-[4-[(cyclopropylcarbonyl)amino]phenyl]-N-(3-thienylmethyl)-	-	CHEMSPIDER	30840805	C23H21N5O2S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV-2 in Vero E6 cells	OCKMJWOFMCSMEX-UHFFFAOYSA-N
33442	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Han SH (2022)	34347470	246239	10350	CCF0058981	2-(benzotriazol-1-yl)-N-[(3-chlorophenyl)methyl]-N-[4-(1H-imidazol-5-yl)phenyl]acetamide|2708934-53-4|CS-0200377|N-[4-(1H-IMIDAZOL-4-YL)PHENYL]-2-(1H-BENZO[D][1,2,3]TRIAZOL-1-YL)-N-(3-CHLOROBENZYL)ACETAMIDE|AKOS040758899|CCF0058981|N-(4-(1H-IMIDAZOL-5-YL)PHENYL)-2-(1H-BENZO[D][1,2,3]TRIAZOL-1-YL)-N-(3-CHLOROBENZYL)ACETAMIDE|HY-132306|GTPL11658|CCF981|MS-27971|ML300-BASED SC INHIBITOR 41|COMPOUND 41 [PMID: 34347470]|EX-A5913	-	PUBCHEM	156027237	C24H19ClN6O	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV-2 in Vero E6 cells	NQTRFDLUODRJKC-UHFFFAOYSA-N
33444	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Boby ML (2023)	37943932	245995	10316	MAT-POS-e194df51-1	KG9|MAT-POS-E194DF51-1|(4S)-6-CHLORO-2-[(1-CYANOCYCLOPROPYL)METHANESULFONYL]-N-(ISOQUINOLIN-4-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDE	-	PUBCHEM	156906151	C24H21ClN4O3S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV-2 in A549-ACE2-TMPRSS2 cells and HeLa-ACE2 cells; COVID Moonshot	YAYDSAMHSQCKIM-OAQYLSRUSA-N
33446	4383848	43740568	GU280_gp02	S	spike|SARS-CoV2 S|SARS-CoV2 spike|S protein|surface|SARS-CoV-2 spike|SARS-CoV-2 S|SPIKE_SARS2|PRO_0000449646	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Ohashi H (2021)	33817567	245721	10211	Cepharanthine	Cepharanthine|Cepharanthin|Cepharantin|(+)-cepharanthine|O-Methylcepharanoline|6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan|6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]oxyacanthan|CEP|(14S,27R)-22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene|MFCD00210482|7592YJ0J6T|[14aS-(14aR*,26aS*)]-2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl- H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline|FK0527000	-	CHEMSPIDER	9791	C37H38N2O6	small molecule	-	481-49-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Spike-ACE2 interaction inhibitor, Spike binding (computational); antiviral activity against SARS-CoV-2 in VeroE6/TMPRSS2 cells and Calu-3 cells	YVPXVXANRNDGTA-WDYNHAJCSA-N
33447	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Ohashi H (2021)	33817567	245721	213	Nelfinavir	Viracept	viracept|viracept -50mg|virace	DRUGBANK	DB00220	C32H45N3O4S	small molecule	J05AE04	159989-64-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor, Viral Mpro/3CLpro binding (computational); antiviral activity against SARS-CoV-2 in VeroE6/TMPRSS2 cells and Calu-3 cells	QAGYKUNXZHXKMR-HKWSIXNMSA-N
33448	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Geng ZZ (2023)	37561993	246240	10329	benzyl 3-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl]-2-azaspiro[4.4]nonane-2-carboxylate	MPI60|HY-155813|CS-0887714	-	PUBCHEM	168510422	C24H31N3O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	OYFTZDRWXGWCFB-NFBCFJMWSA-N
33460	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Sanders BC (2023)	36977673	241489	10336	PLpro inhibitor 7	METHYL (R,E)-4-(2-(3-(2-((1-(NAPHTHALEN-1-YL)ETHYL)CARBAMOYL)PHENYL)PROPANOYL)HYDRAZINEYL)-4-OXOBUT-2-ENOATE|METHYL (E)-4-[2-[3-[2-[[(1R)-1-NAPHTHALEN-1-YLETHYL]CARBAMOYL]PHENYL]PROPANOYL]HYDRAZINYL]-4-OXOBUT-2-ENOATE|PLPRO INHIBITOR 7|PLPRO-IN-7|GTPL12596|PLPRO INHIBITOR 7 [PMID: 36977673]|GLXC-25760	-	PUBCHEM	164946795	C27H27N3O5	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral PLpro papain-like protease	QEHLIVYTSIQCOG-IECKCJDVSA-N
33461	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Otava T (2021)	34152728	246035	10279	TO507	(2S)-2-Amino-4-[({(2S,3S,4R,5R)-5-[4-amino-5-(3-quinolinylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-dihydroxytetrahydro-2-furanyl}methyl)sulfanyl]butanoic acid (non-preferred name)	-	CHEMSPIDER	123962500	C26H26N6O5S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral nsp14 methyltransferase Inhibitor	SPMFBZXXQBXKFX-LUOSIZPJSA-N
33462	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Nigam A (2023)	888800001013	245490	10198	NSC620333	9H-Purin-6-amine, 9-[5-S-[(4-chlorophenyl)methyl]-5-thiopentofuranosyl]-|9-[5-S-(4-Chlorobenzyl)-5-thiopentofuranosyl]-9H-purin-6-amine	-	CHEMSPIDER	319110	C17H18ClN5O3S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral nsp14 methyltransferase Inhibitor	IJLUIMSYWGUZCP-UHFFFAOYSA-N
33463	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Grabinski W (2023)	888800001014	245491	10187	Meisoindigo	(3E)-1-Methyl-3-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1,3-dihydro-2H-indol-2-one|2H-Indol-2-one, 3-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,3-dihydro-1-methyl-, (3E)-|(E)-1-methyl-1H,1'H,2H,2'H-[3,3'-biindolylidene]-2,2'-dione|Methylisoindigotin|Meisoindigo	-	CHEMSPIDER	4586320	C17H12N2O2	small molecule	-	97207-47-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	QNOCRUSVMMAKSC-CCEZHUSRSA-N
33468	4383856	43740578	GU280_gp01_nsp7	nsp7	ORF1ab|ORF1ab-nsp7|SARS-CoV2 nsp7|SARS-CoV-2 nsp7|R1AB_SARS2|PRO_0000449625	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Rani R (2023)	888800000987	244287	10211	Cepharanthine	Cepharanthine|Cepharanthin|Cepharantin|(+)-cepharanthine|O-Methylcepharanoline|6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan|6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]oxyacanthan|CEP|(14S,27R)-22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene|MFCD00210482|7592YJ0J6T|[14aS-(14aR*,26aS*)]-2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl- H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline|FK0527000	-	CHEMSPIDER	9791	C37H38N2O6	small molecule	-	481-49-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral RNA-dependent RNA polymerase (RdRp) nsp12-nsp7-nsp8 complex inhibitor, nsp7-nsp8 binding; antiviral activity against SARS-CoV-2 in VeroE6 cells	YVPXVXANRNDGTA-WDYNHAJCSA-N
33469	4383856	43740578	GU280_gp01_nsp7	nsp7	ORF1ab|ORF1ab-nsp7|SARS-CoV2 nsp7|SARS-CoV-2 nsp7|R1AB_SARS2|PRO_0000449625	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Rani R (2023)	888800000987	244287	10264	Fangchinoline	Limacine|(1beta)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol|7-O-Demethyltetrandine|DR9280000|Frangchinoline|MFCD03427706|(+)-Limacine|Fangchinoline	-	CHEMSPIDER	66173	C37H40N2O6	small molecule	-	436-77-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral RNA-dependent RNA polymerase (RdRp) nsp12-nsp7-nsp8 complex inhibitor, nsp7-nsp8 binding; antiviral activity against SARS-CoV-2 in VeroE6 cells	IIQSJHUEZBTSAT-VMPREFPWSA-N
33470	4383856	43740578	GU280_gp01_nsp7	nsp7	ORF1ab|ORF1ab-nsp7|SARS-CoV2 nsp7|SARS-CoV-2 nsp7|R1AB_SARS2|PRO_0000449625	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Rani R (2023)	888800000987	244287	10276	Sennoside B	Sennoside B|(9R,9'S)-5,5'-Bis(beta-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid|[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(beta-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-|(9R,9'S)-4,4'-Dihydroxy-10,10'-dioxo-5,5'-bis{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid|[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(?-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-	-	CHEMSPIDER	82569	C42H38O20	small molecule	-	128-57-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral RNA-dependent RNA polymerase (RdRp) nsp12-nsp7-nsp8 complex inhibitor, nsp7-nsp8 binding; antiviral activity against SARS-CoV-2 in VeroE6 cells	IPQVTOJGNYVQEO-AIFLABODSA-N
33471	4383857	43740578	GU280_gp01_nsp8	nsp8	ORF1ab|ORF1ab-nsp8|SARS-CoV2 nsp8|SARS-CoV-2 nsp8|R1AB_SARS2|PRO_0000449626	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Rani R (2023)	888800000987	244287	10211	Cepharanthine	Cepharanthine|Cepharanthin|Cepharantin|(+)-cepharanthine|O-Methylcepharanoline|6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan|6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]oxyacanthan|CEP|(14S,27R)-22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene|MFCD00210482|7592YJ0J6T|[14aS-(14aR*,26aS*)]-2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl- H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline|FK0527000	-	CHEMSPIDER	9791	C37H38N2O6	small molecule	-	481-49-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral RNA-dependent RNA polymerase (RdRp) nsp12-nsp7-nsp8 complex inhibitor, nsp7-nsp8 binding; antiviral activity against SARS-CoV-2 in VeroE6 cells	YVPXVXANRNDGTA-WDYNHAJCSA-N
33472	4383857	43740578	GU280_gp01_nsp8	nsp8	ORF1ab|ORF1ab-nsp8|SARS-CoV2 nsp8|SARS-CoV-2 nsp8|R1AB_SARS2|PRO_0000449626	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Rani R (2023)	888800000987	244287	10264	Fangchinoline	Limacine|(1beta)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol|7-O-Demethyltetrandine|DR9280000|Frangchinoline|MFCD03427706|(+)-Limacine|Fangchinoline	-	CHEMSPIDER	66173	C37H40N2O6	small molecule	-	436-77-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral RNA-dependent RNA polymerase (RdRp) nsp12-nsp7-nsp8 complex inhibitor, nsp7-nsp8 binding; antiviral activity against SARS-CoV-2 in VeroE6 cells	IIQSJHUEZBTSAT-VMPREFPWSA-N
33473	4383857	43740578	GU280_gp01_nsp8	nsp8	ORF1ab|ORF1ab-nsp8|SARS-CoV2 nsp8|SARS-CoV-2 nsp8|R1AB_SARS2|PRO_0000449626	2697049	Severe acute respiratory syndrome coronavirus 2	sars-cov-2 inhibitor	target	Rani R (2023)	888800000987	244287	10276	Sennoside B	Sennoside B|(9R,9'S)-5,5'-Bis(beta-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid|[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(beta-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-|(9R,9'S)-4,4'-Dihydroxy-10,10'-dioxo-5,5'-bis{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid|[9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(?-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)-	-	CHEMSPIDER	82569	C42H38O20	small molecule	-	128-57-4	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral RNA-dependent RNA polymerase (RdRp) nsp12-nsp7-nsp8 complex inhibitor, nsp7-nsp8 binding; antiviral activity against SARS-CoV-2 in VeroE6 cells	IPQVTOJGNYVQEO-AIFLABODSA-N
33477	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Elshaier YAMM (2023)	888800001037	245514	10341	Chlorpheniramine Maleate	UNII-V1Q0O9OJ9Z|RU-TUSS CAPSULES|HY-B0286A|CHLORPHENIRAMINE MALEATE COMPONENT OF ISOCLOR|CHLORPROPHENPYRIDAMINE MALEATE|ZODRYL AC 40|HMS501N18|SINE OFF|CHLORPHENIRAMINE MALEATE 4 MG|CHLOROPROPHENPYRIDAMINE MALEATE|2-(P-CHLORO-.ALPHA.-(2-(DIMETHYLAMINO)ETHYL)BENZYL)PYRIDINE MALEATE (1:1)|2-PYRIDINEPROPANAMINE, GAMMA-(4-CHLOROPHENYL)-N,N-DIMETHYL-, (Z)-2-BUTENEDIOATE (1:1)|CHLORPHENIRAMINE MALEATE COMPONENT OF DRIZE|CHLORPHENIRAMINE MALEATE COMPONENT OF ADVIL ALLERGY SINUS|2-PYRIDINEPROPANAMINE, .GAMMA.-(4-CHLOROPHENYL)-N,N-DIMETHYL-, (Z)-2-BUTENEDIOATE (1:1)|113-92-8|CHLORPHENAMINE MALEATE [EP MONOGRAPH]|CHLORPHENIRAMINE MALEATE COMPONENT OF CODIMAL-L.A. 12|ALUNEX|AKOS015951220|SPRINSOL|DTXCID00321|CLORRELIEF KIDS|CLEAR CHOICE ALLERGY RELIEF|ALLERGY RELIEF4 HOUR|SMR000653461|(+/-)-CHLORPHENIRAMINE.MALEATE, 1MG/ML IN METHANOL|CHLOR-TRIMETON 12 HOUR|AS-13167|MEDIQUE CHLORPHEN|PHARMAKON1600-01505530|(A+/-)-CHLORPHENIRAMINE MALEATE|HMS2232B23|ZODRYL AC 25|2-(P-CHLORO-ALPHA-(2-(DIMETHYLAMINO)ETHYL)BENZYL)PYRIDINE MALEATE (1:1)|(Z)-BUT-2-ENEDIOIC ACID;3-(4-CHLOROPHENYL)-N,N-DIMETHYL-3-PYRIDIN-2-YLPROPAN-1-AMINE|CHLORPHENAMINE MALEATES|MALEATE, CHLORPHENIRAMINE|PUERMIN|ANTI ALLERGY|CCRIS 1418|CHLORPHENIRAMINE (MALEATE)|(+/-)-CHLORPHENIRAMINE MALEATE|(Y)-CHLORPHENIRAMINE MALEATE|NC00286|NCGC00260946-01|PHARBECHLOR|TOX21_500261|CHLORPHENIRAMINE MALEATE [VANDF]|W-108612|MFCD00069225|ALLERCLOR|CHLORPHENIRAMINE MALEATE [ORANGE BOOK]|CHLORPHENAMINE MALEATE, EUROPEAN PHARMACOPOEIA (EP) REFERENCE STANDARD|HISTASPAN|NSC 756684|CHLORPHENAMINE MALEATE [WHO-DD]|CVSHEALTH CHILDRENS ALLERGY RELIEF POPS|( INVERTED QUESTION MARK)-CHLORPHENIRAMINE MALEATE|C 3025|EFIDAC 24 CHLORPHENIRAMINE MALEATE|(?)-CHLORPHENIRAMINE MALEATE|LOHIST|CCG-101036|AC-267|HMS1568G16|CHLORTRIMETON|CHLORPHENIRAMINE MALEATE (USP-RS)|PHENALIN|CHLOR-TRIMETON (TN)|CHLORPHENIRAMINE MALEATE, UNITED STATES PHARMACOPEIA (USP) REFERENCE STANDARD|DL-2(-P-CHLORO-ALPHA-2-(DIMETHYLAMINO)ETHYLBENZYL)PYRIDINE BIMALEATE|CCG-221565|CONTAC COMPONENT CHLORPHENIRAMINE MALEATE|WAL-FINATE|SR-01000075261|CHLORPHENIRAMINE MALEATE COMPONENT OF TRIAMINIC|(+/-)-CHLORPHENIRAMINE MALEATE SALT, >=99% (PERCHLORIC ACID TITRATION)|CHLORPHENIRAMINE MALEATE (USP:JAN)|EU-0100261|CHLOR-TRIPOLON|CHLORPHENAMINE HYDROGEN MALEATE|DBAKFASWICGISY-BTJKTKAUSA-N|HMS3712G16|SR-01000075261-9|1-(P-CHLORPHENYL)-1-(2-PYRIDYL)-3-DIMETHYLAMINOPROPAN MALEAT [GERMAN]|TELDRIN (TN)|SMR000466271|KLOROMIN|C07780|CHLOR-TRIMETON MALEATE|CHLOROPHENIRAMINE MALEATE|POLARONIL [GERMAN]|AMF0009|[3-(4-CHLORO-PHENYL)-3-PYRIDIN-2-YL-PROPYL]-DIMETHYL-AMINE MALEATE|LP00261|SW196372-4|PYRIDAMAL 100|GAMMA-(4-CHLOROPHENYL)-N,N-DIMETHYL-2-PYRIDINEPROPANAMINE(Z)-2-BUTENEDIOATE (1:1)|SILDEC PE|PYRIDAMAL-100|CHLOR-TRIMETON ALLERGY|CHLORPHEN-12|ZODRYL AC 50|CHLORPHENIRAMINE MALEATE SALT|CHLORPHENAMINE MALEATE (EP MONOGRAPH)|PRESTWICK_57|NASOHIST|CHLORPHENAMINE HYDROGEN MALEATE [WHO-IP]|HMS2095G16|CHLORPHENIRAMINE MALEATE COMPONENT OF CONTAC|DL-2-(P-CHLORO-ALPHA-2-(DIMETHYLAMINO)ETHYLBENZYL)PYRIDINE MALEATE|ALLERGY TIME|HMS3260F04|TRIAMINIC COMPONENT CHLORPHENIRAMINE MALEATE|CHLORPHENIRAMINE MALEATE (USP MONOGRAPH)|DL-CHLORPHENIRAMINE MALEATE|HISTASPAN-PLUS|ED CHLORPED JR|EFIDAC|LORPHEN|MLS001424173|CHLORPHENAMINI HYDROGENOMALEAS [WHO-IP LATIN]|CHLORMENE|CHLORPHENAMINI HYDROGENOMALEAS|SR-01000075261-1|CLORRELIEF|HISTAPAN|HMS2093N19|CHLOR-TRIMETON|C-METON|CHLORPHENIRAMINE MALEATE [USP-RS]|IBIOTON|CHLOROPHENAMINEMALEATE|HISTALEN|CHLORPHENIRAMINE MALEATE 4MG|GAMMA-(4-CHLOROPHENYL)-N,N-DIMETHYL-2-PYRIDINEPROPANAMINE (Z)-2-BUTENEDIOATE|1-P-CHLOROPHENYL-1-(2-PYRIDYL)-3-DIMETHYLAMINOPROPANE MALEATE|NCGC00093720-01|ANTAGONATE|CHLORPHENIRAMINE MALEATE, PHARMACEUTICAL SECONDARY STANDARD; CERTIFIED REFERENCE MATERIAL|CODIMAL-L.A. 12 COMPONENT CHLORPHENIRAMINE MALEATE|CHLORPHENIRAMINE MALEATE OROS TABLETS|HMS2230F21|CHLORPHENIRAMINE MALEATE [MI]|Q27106157|ALLERGIN|ALKA-SELTZER PLUS|F2173-0923|D70131|V1Q0O9OJ9Z|2-PYRIDINEPROPANAMINE, GAMMA-(4-CHLOROPHENYL)-N,N-DIMETHYL-, (2Z)-2-BUTENEDIOATE (1:1)|CHLORPHENIRAMINE MALEATE (JP17/USP)|HISTADUR DURA-TABS|CHLORPHENAMINE MALEATE [MART.]|HMS2051L14|HISTASPAN-D|NCI-C55265|ISOCLOR COMPONENT CHLORPHENIRAMINE MALEATE|CHLOR-TRIMETON INJECTION|NSC-756684|PHENETRON|D00665|3-(4-CHLOROPHENYL)-N,N-DIMETHYL-3-PYRIDIN-2-YLPROPAN-1-AMINIUM (2Z)-3-CARBOXYPROP-2-ENOATE|NEORESTAMIN|CARBINOXAMIDE MALEATE|1-(N,N-DIMETHYLAMINO)-3-(P-CHLOROPHENYL-3-ALPHA-PYRIDYL)PROPANE MALEATE|PIRITON|CHLORPHENIRAMINE MALEATE COMPONENT OF DEMAZIN|CHLORPHENAMINE MALEATE (MART.)|DEMAZIN COMPONENT CHLORPHENIRAMINE MALEATE|CHLORPHENIRAMINE MALEATE COMPONENT OF ORNADE|ZODRYL AC 80|(+/-)-CHLORPHENIRAMINE.MALEATE|ZODRYL AC 30|3-(4-CHLOROPHENYL)-N,N-DIMETHYL-3-(PYRIDIN-2-YL)PROPAN-1-AMINE MALEATE|ORNADE COMPONENT CHLORPHENIRAMINE MALEATE|PYRIDINE, 2-(P-CHLORO-ALPHA-(2-(DIMETHYLAMINO)ETHYL)BENZYL)-, MALEATE (1:1)|SYNISTAMIN|MLS001148230|NSC759156|HABEN HERB|CHLORPHENIRAMINE MALEATE [USP:JAN]|MLS000758311|CHLORPHENAMINE MALEATE|CCG-220117|ZODRYL AC 60|S1816|ADVIL ALLERGY SINUS COMPONENT CHLORPHENIRAMINE MALEATE|PYRIDAMAL|CHLORPHENIRAMINE MALEATE [JAN]|CORFEN|HMS3884O10|ONLY FORALLERGY|CHLORPHENAMINEMALEATE|DEHIST|PIRIEX|(+/-)-CHLORPHENIRAMINE MALEATE SALT|CHLORTABS|NCGC00093720-02|CHLOR-TRIMETON OD|DRIZE COMPONENT CHLORPHENIRAMINE MALEATE|CHLOR-ALLERGY 4-HOUR|M.P. CHLORCAPS T.D.|1-(P-CHLORPHENYL)-1-(2-PYRIDYL)-3-DIMETHYLAMINOPROPAN MALEAT|EINECS 204-037-5|CHLORPHENIRAMINE MALEATE [USP MONOGRAPH]|CHLORPHENIRAMINE MALEATE	-	PUBCHEM	5281068	C20H23ClN2O4	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro protease inhibitor; authors found that CPM displayed dose-dependent antiviral effects against SARS-CoV-2 in Vero E6 cells, the action is thought to occur through multiple targets including Mpro and Spike	DBAKFASWICGISY-BTJKTKAUSA-N
33480	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Choudhary S (2024)	38059400	244298	10220	azadirachtin	Azadirachtin|dimethyl (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-10-(acetyloxy)-3,5-dihydroxy-4-[(1aR,2S,3aS,6aS,7S,7aS)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-naphtho[1,8a-c:4,5-b'c']difuran-5,10a(8H)-dicarboxylate|O4U1SAF85H|Dimethyl-(2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-10-acetoxy-3,5-dihydroxy-4-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.0~2,6~.0~9,11~]dodec-3-en-9-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-furo[3',4':4,4a]naphtho[1,8-bc]furan-5,10a(8H)-dicarboxylat|Dimethyl (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-10-acetoxy-3,5-dihydroxy-4-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.0~2,6~.0~9,11~]dodec-3-en-9-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-furo[3',4':4,4a]naphtho[1,8-bc]furan-5,10a(8H)-dicarboxylate|1H,7H-naphtho[1,8a-c:4,5-b'c']difuran-5,10a(8H)-dicarboxylic acid, 10-(acetyloxy)octahydro-3,5-dihydroxy-4-methyl-8-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-, dimethyl ester, (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-	-	CHEMSPIDER	4444685	C35H44O16	small molecule	-	11141-17-6	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV-2 in Vero cells	FTNJWQUOZFUQQJ-NDAWSKJSSA-N
33481	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Choudhary S (2024)	38059400	244298	10160	withanolide A	(5alpha,6alpha,7alpha,22R)-6,7-Epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid delta-lactone|MFCD07779143|Withaniol|(5alpha,6alpha,7alpha,8xi,22R)-5,20-Dihydroxy-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione|Ergosta-2,24-diene-1,26-dione, 6,7:22,26-diepoxy-5,20-dihydroxy-, (5alpha,6alpha,7alpha,8xi,22R)-|withanolide A	-	CHEMSPIDER	9469353	C28H38O6	small molecule	-	32911-62-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV-2 in Vero cells	DXWHOKCXBGLTMQ-SFQAJKIESA-N
33482	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Choudhary S (2024)	38059400	244298	10220	azadirachtin	Azadirachtin|dimethyl (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-10-(acetyloxy)-3,5-dihydroxy-4-[(1aR,2S,3aS,6aS,7S,7aS)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-naphtho[1,8a-c:4,5-b'c']difuran-5,10a(8H)-dicarboxylate|O4U1SAF85H|Dimethyl-(2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-10-acetoxy-3,5-dihydroxy-4-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.0~2,6~.0~9,11~]dodec-3-en-9-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-furo[3',4':4,4a]naphtho[1,8-bc]furan-5,10a(8H)-dicarboxylat|Dimethyl (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-10-acetoxy-3,5-dihydroxy-4-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.0~2,6~.0~9,11~]dodec-3-en-9-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-furo[3',4':4,4a]naphtho[1,8-bc]furan-5,10a(8H)-dicarboxylate|1H,7H-naphtho[1,8a-c:4,5-b'c']difuran-5,10a(8H)-dicarboxylic acid, 10-(acetyloxy)octahydro-3,5-dihydroxy-4-methyl-8-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-, dimethyl ester, (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-	-	CHEMSPIDER	4444685	C35H44O16	small molecule	-	11141-17-6	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral PLpro protease inhibitor; antiviral activity against SARS-CoV-2 in Vero cells	FTNJWQUOZFUQQJ-NDAWSKJSSA-N
33483	4383852	43740578	GU280_gp01_nsp3	nsp3	ORF1ab|ORF1ab-nsp3|SARS-CoV2 nsp3|SARS-CoV-2 nsp3|R1AB_SARS2|PRO_0000449621	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Choudhary S (2024)	38059400	244298	10160	withanolide A	(5alpha,6alpha,7alpha,22R)-6,7-Epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid delta-lactone|MFCD07779143|Withaniol|(5alpha,6alpha,7alpha,8xi,22R)-5,20-Dihydroxy-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione|Ergosta-2,24-diene-1,26-dione, 6,7:22,26-diepoxy-5,20-dihydroxy-, (5alpha,6alpha,7alpha,8xi,22R)-|withanolide A	-	CHEMSPIDER	9469353	C28H38O6	small molecule	-	32911-62-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral PLpro protease inhibitor; antiviral activity against SARS-CoV-2 in Vero cells	DXWHOKCXBGLTMQ-SFQAJKIESA-N
33484	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Unoh Y (2022)	35352927	239599	9978	Ensitrelvir	1,3,5-Triazine-2,4(1H,3H)-dione, 6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]dihydro-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-, (6E)-|(6E)-6-[(6-Chloro-2-methyl-2H-indazol-5-yl)imino]-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-(2,4,5-trifluorobenzyl)-1,3,5-triazinane-2,4-dione	-	CHEMSPIDER	115007411	C22H17ClF3N9O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor; antiviral activity against SARS-CoV in VeroE6/TMPRSS2 cells	QMPBBNUOBOFBFS-UHFFFAOYSA-N
33485	4383890	14254602	G128_gp01ab_nsp5	nsp5ab	ORF1ab|nsp5|rep|1AB|MERS-CoV nsp5|orf1ab-nsp5|orf1ab-nsp5ab|nsp5ab|3C-like proteinase|R1AB_CVEMC|PRO_0000422443	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor/mers-cov inhibitor	target	Unoh Y (2022)	35352927	239599	9978	Ensitrelvir	1,3,5-Triazine-2,4(1H,3H)-dione, 6-[(6-chloro-2-methyl-2H-indazol-5-yl)imino]dihydro-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-[(2,4,5-trifluorophenyl)methyl]-, (6E)-|(6E)-6-[(6-Chloro-2-methyl-2H-indazol-5-yl)imino]-3-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-1-(2,4,5-trifluorobenzyl)-1,3,5-triazinane-2,4-dione	-	CHEMSPIDER	115007411	C22H17ClF3N9O2	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral Mpro/3CLpro protease inhibitor; antiviral activity against MERS-CoV in VeroE6/TMPRSS2 cells	QMPBBNUOBOFBFS-UHFFFAOYSA-N
33486	4383854	43740578	GU280_gp01_nsp5	nsp5	ORF1ab|ORF1ab-nsp5|SARS-CoV2 nsp5|SARS-CoV-2 nsp5|Mpro|3CLpro|3C-like proteinase|R1AB_SARS2|PRO_0000449623	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor	target	Hu X (2022)	36146880	246025	10199	YH-53	N-[(2S)-1-({(2S)-1-(1,3-Benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxo-3-pyrrolidinyl]-2-propanyl}amino)-4-methyl-1-oxo-2-pentanyl]-4-methoxy-1H-indole-2-carboxamide|1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-2-(2-benzothiazolyl)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]ethyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-	-	CHEMSPIDER	30837128	C30H33N5O5S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	JBLLRCOZJMVOAE-HSQYWUDLSA-N
33487	4383943	1489680	SARS-CoV-1ab-nsp5ab	nsp5ab	nsp5|sars1ab|orf1ab|SARS-CoV nsp5ab|SARS-CoV nsp5|SARS-CoV sars1ab|orf1ab-nsp5|orf1ab-nsp5ab|pp1ab|3C-like proteinase|3CL-PRO|3CLp|R1AB_CVHSA|PRO_0000037312	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor	target	Hu X (2022)	36146880	246025	10199	YH-53	N-[(2S)-1-({(2S)-1-(1,3-Benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxo-3-pyrrolidinyl]-2-propanyl}amino)-4-methyl-1-oxo-2-pentanyl]-4-methoxy-1H-indole-2-carboxamide|1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-2-(2-benzothiazolyl)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]ethyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-	-	CHEMSPIDER	30837128	C30H33N5O5S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	JBLLRCOZJMVOAE-HSQYWUDLSA-N
33488	4383890	14254602	G128_gp01ab_nsp5	nsp5ab	ORF1ab|nsp5|rep|1AB|MERS-CoV nsp5|orf1ab-nsp5|orf1ab-nsp5ab|nsp5ab|3C-like proteinase|R1AB_CVEMC|PRO_0000422443	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor	target	Hu X (2022)	36146880	246025	10199	YH-53	N-[(2S)-1-({(2S)-1-(1,3-Benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxo-3-pyrrolidinyl]-2-propanyl}amino)-4-methyl-1-oxo-2-pentanyl]-4-methoxy-1H-indole-2-carboxamide|1H-Indole-2-carboxamide, N-[(1S)-1-[[[(1S)-2-(2-benzothiazolyl)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]ethyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-	-	CHEMSPIDER	30837128	C30H33N5O5S	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction : Viral Mpro/3CLpro protease inhibitor	JBLLRCOZJMVOAE-HSQYWUDLSA-N
33489	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Pruijssers AJ (2020)	32668216	246028	9968	Remdesivir	L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile|Veklury|remdesivir|UNII:3QKI37EEHE|GS-5734|2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name)	-	CHEMSPIDER	58827832	C27H35N6O8P	small molecule	-	1809249-37-3	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor; antiviral activity against SARS-CoV-2 in Vero E6 cells and Calu3 2B4 cells	RWWYLEGWBNMMLJ-YSOARWBDSA-N
33490	4383860	43740578	GU280_gp01_nsp12	nsp12	ORF1ab|ORF1ab-nsp12|SARS-CoV2 nsp12|SARS-CoV-2 nsp12|RNA-directed RNA polymerase|R1AB_SARS2|PRO_0000449629	2697049	Severe acute respiratory syndrome coronavirus 2	inhibitor/sars-cov-2 inhibitor	target	Pruijssers AJ (2020)	32668216	246028	10228	GS-441524	GS-441524|(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furancarbonitrile|(2R,3R,4S,5R)-2-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile	-	CHEMSPIDER	28499294	C12H13N5O4	small molecule	-	1191237-69-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor; antiviral activity against SARS-CoV-2 in Vero E6 cells and Calu3 2B4 cells	BRDWIEOJOWJCLU-LTGWCKQJSA-N
33493	4383949	1489680	SARS-CoV-1ab-nsp12ab	nsp12ab	nsp12|sars1ab|orf1ab|SARS-CoV nsp12ab|SARS-CoV nsp12|SARS-CoV sars1ab|orf1ab-nsp12|orf1ab-nsp12ab|pp1ab|RNA-directed RNA polymerase|Pol|RdRp|R1AB_CVHSA|PRO_0000037318	694009	Severe acute respiratory syndrome-related coronavirus	inhibitor/sars-cov inhibitor	target	Agostini ML (2018)	29511076	222024	10228	GS-441524	GS-441524|(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furancarbonitrile|(2R,3R,4S,5R)-2-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile	-	CHEMSPIDER	28499294	C12H13N5O4	small molecule	-	1191237-69-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor; antiviral activity against SARS-CoV in primary human airway epithelial cell (HAE) cultures	BRDWIEOJOWJCLU-LTGWCKQJSA-N
33494	4383896	14254602	G128_gp01ab_nsp12	nsp12ab	ORF1ab|nsp12|rep|1AB|MERS-CoV nsp12|orf1ab-nsp12|orf1ab-nsp12ab|nsp12ab|RNA polymerase|R1AB_CVEMC|PRO_0000422449	1335626	Middle-East Respiratory Syndrome-related Coronavirus	inhibitor/mers-cov inhibitor	target	Agostini ML (2018)	29511076	222024	10228	GS-441524	GS-441524|(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furancarbonitrile|(2R,3R,4S,5R)-2-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile	-	CHEMSPIDER	28499294	C12H13N5O4	small molecule	-	1191237-69-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project MERS-CoV direct chemical interaction: Viral RNA-directed RNA polymerase inhibitor; antiviral activity against MERS-CoV in primary human airway epithelial cell (HAE) cultures	BRDWIEOJOWJCLU-LTGWCKQJSA-N
