#BioGRID Chemical Interaction ID	BioGRID Gene ID	Entrez Gene ID	Systematic Name	Official Symbol	Synonyms	Organism ID	Organism	Action	Interaction Type	Author	Pubmed ID	BioGRID Publication ID	BioGRID Chemical ID	Chemical Name	Chemical Synonyms	Chemical Brands	Chemical Source	Chemical Source ID	Molecular Formula	Chemical Type	ATC Codes	CAS Number	Curated By	Method	Method Description	Related BioGRID Gene ID	Related Entrez Gene ID	Related Systematic Name	Related Official Symbol	Related Synonyms	Related Organism ID	Related Organism	Related Type	Notes	InChIKey
1387	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Chen X (2002)	11752352	171740	107	Bevacizumab	antiVEGF|Avastin	avastin	DRUGBANK	DB00112	C6538H10034N1716O2033S44	biologic	L01XC07	216974-75-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
1388	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Gerber HP (2005)	15705858	172458	107	Bevacizumab	antiVEGF|Avastin	avastin	DRUGBANK	DB00112	C6538H10034N1716O2033S44	biologic	L01XC07	216974-75-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
2101	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	activator	target	Whitehead JP (2006)	16634986	173038	125	Adenosine monophosphate	Adenosine 5'-(dihydrogen phosphate)|5'-Adenosine monophosphate|Adenosine 5'-monophosphate|Adenosine-5'-monophosphoric acid|PAdo|Adenylate|Phosphate d'adenosine|Adenosine-5'-Monophosphate|5'-O-Phosphonoadenosine|Adenosine phosphate|Ado5'p|Adenosine-5'p|AMP|Fosfato de adenosina|5'-Adenylic acid|ADENOSINE monophosphate|Phosaden|Adenylic acid|Phosphaden|5'-AMP|Adenosini phosphas|Adenosine 5'-phosphate	-	DRUGBANK	DB00131	C10H14N5O7P	small molecule	-	61-19-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UDMBCSSLTHHNCD-KQYNXXCUSA-N
2102	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	activator	target	Ruderman NB (2006)	16642960	173039	125	Adenosine monophosphate	Adenosine 5'-(dihydrogen phosphate)|5'-Adenosine monophosphate|Adenosine 5'-monophosphate|Adenosine-5'-monophosphoric acid|PAdo|Adenylate|Phosphate d'adenosine|Adenosine-5'-Monophosphate|5'-O-Phosphonoadenosine|Adenosine phosphate|Ado5'p|Adenosine-5'p|AMP|Fosfato de adenosina|5'-Adenylic acid|ADENOSINE monophosphate|Phosaden|Adenylic acid|Phosphaden|5'-AMP|Adenosini phosphas|Adenosine 5'-phosphate	-	DRUGBANK	DB00131	C10H14N5O7P	small molecule	-	61-19-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UDMBCSSLTHHNCD-KQYNXXCUSA-N
2103	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	activator	target	McGee SL (2006)	16620308	173036	125	Adenosine monophosphate	Adenosine 5'-(dihydrogen phosphate)|5'-Adenosine monophosphate|Adenosine 5'-monophosphate|Adenosine-5'-monophosphoric acid|PAdo|Adenylate|Phosphate d'adenosine|Adenosine-5'-Monophosphate|5'-O-Phosphonoadenosine|Adenosine phosphate|Ado5'p|Adenosine-5'p|AMP|Fosfato de adenosina|5'-Adenylic acid|ADENOSINE monophosphate|Phosaden|Adenylic acid|Phosphaden|5'-AMP|Adenosini phosphas|Adenosine 5'-phosphate	-	DRUGBANK	DB00131	C10H14N5O7P	small molecule	-	61-19-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UDMBCSSLTHHNCD-KQYNXXCUSA-N
2104	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	activator	target	Neurath KM (2006)	16518831	173037	125	Adenosine monophosphate	Adenosine 5'-(dihydrogen phosphate)|5'-Adenosine monophosphate|Adenosine 5'-monophosphate|Adenosine-5'-monophosphoric acid|PAdo|Adenylate|Phosphate d'adenosine|Adenosine-5'-Monophosphate|5'-O-Phosphonoadenosine|Adenosine phosphate|Ado5'p|Adenosine-5'p|AMP|Fosfato de adenosina|5'-Adenylic acid|ADENOSINE monophosphate|Phosaden|Adenylic acid|Phosphaden|5'-AMP|Adenosini phosphas|Adenosine 5'-phosphate	-	DRUGBANK	DB00131	C10H14N5O7P	small molecule	-	61-19-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UDMBCSSLTHHNCD-KQYNXXCUSA-N
2105	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	activator	target	Richter EA (2006)	16513051	173035	125	Adenosine monophosphate	Adenosine 5'-(dihydrogen phosphate)|5'-Adenosine monophosphate|Adenosine 5'-monophosphate|Adenosine-5'-monophosphoric acid|PAdo|Adenylate|Phosphate d'adenosine|Adenosine-5'-Monophosphate|5'-O-Phosphonoadenosine|Adenosine phosphate|Ado5'p|Adenosine-5'p|AMP|Fosfato de adenosina|5'-Adenylic acid|ADENOSINE monophosphate|Phosaden|Adenylic acid|Phosphaden|5'-AMP|Adenosini phosphas|Adenosine 5'-phosphate	-	DRUGBANK	DB00131	C10H14N5O7P	small molecule	-	61-19-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UDMBCSSLTHHNCD-KQYNXXCUSA-N
2119	111552	5565	-	PRKAB2	-	9606	Homo sapiens	activator	target	Imming P (2006)	17016423	171742	125	Adenosine monophosphate	Adenosine 5'-(dihydrogen phosphate)|5'-Adenosine monophosphate|Adenosine 5'-monophosphate|Adenosine-5'-monophosphoric acid|PAdo|Adenylate|Phosphate d'adenosine|Adenosine-5'-Monophosphate|5'-O-Phosphonoadenosine|Adenosine phosphate|Ado5'p|Adenosine-5'p|AMP|Fosfato de adenosina|5'-Adenylic acid|ADENOSINE monophosphate|Phosaden|Adenylic acid|Phosphaden|5'-AMP|Adenosini phosphas|Adenosine 5'-phosphate	-	DRUGBANK	DB00131	C10H14N5O7P	small molecule	-	61-19-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UDMBCSSLTHHNCD-KQYNXXCUSA-N
2120	111552	5565	-	PRKAB2	-	9606	Homo sapiens	activator	target	Overington JP (2006)	17139284	171741	125	Adenosine monophosphate	Adenosine 5'-(dihydrogen phosphate)|5'-Adenosine monophosphate|Adenosine 5'-monophosphate|Adenosine-5'-monophosphoric acid|PAdo|Adenylate|Phosphate d'adenosine|Adenosine-5'-Monophosphate|5'-O-Phosphonoadenosine|Adenosine phosphate|Ado5'p|Adenosine-5'p|AMP|Fosfato de adenosina|5'-Adenylic acid|ADENOSINE monophosphate|Phosaden|Adenylic acid|Phosphaden|5'-AMP|Adenosini phosphas|Adenosine 5'-phosphate	-	DRUGBANK	DB00131	C10H14N5O7P	small molecule	-	61-19-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UDMBCSSLTHHNCD-KQYNXXCUSA-N
2128	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	activator	target	Mayes MA (2007)	17167165	173052	125	Adenosine monophosphate	Adenosine 5'-(dihydrogen phosphate)|5'-Adenosine monophosphate|Adenosine 5'-monophosphate|Adenosine-5'-monophosphoric acid|PAdo|Adenylate|Phosphate d'adenosine|Adenosine-5'-Monophosphate|5'-O-Phosphonoadenosine|Adenosine phosphate|Ado5'p|Adenosine-5'p|AMP|Fosfato de adenosina|5'-Adenylic acid|ADENOSINE monophosphate|Phosaden|Adenylic acid|Phosphaden|5'-AMP|Adenosini phosphas|Adenosine 5'-phosphate	-	DRUGBANK	DB00131	C10H14N5O7P	small molecule	-	61-19-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UDMBCSSLTHHNCD-KQYNXXCUSA-N
3727	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	unknown	target	Van Meter TE (2006)	17041888	174029	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3749	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
3750	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	164	Adenosine triphosphate	Adenosine 5'-triphosphate|Adenosine-5'-triphosphate|ATP	-	DRUGBANK	DB00171	C10H16N5O13P3	small molecule	-	56-65-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKHQWZAMYRWXGA-YPLCUDRINA-N
4253	111311	5293	RP11-558F24.3	PIK3CD	APDS|IMD14|P110DELTA|PI3K|p110D	9606	Homo sapiens	unknown	target	Foukas LC (2002)	12145276	174346	194	Caffeine	Cafine|1,3,7-trimethylpurine-2,6-dione|Theine|7-methyltheophylline|Coffein|Methyltheobromine|Koffein|Guaranine|1-methyltheobromine|Thein|tena|1,3,7-trimethyl-2,6-dioxopurine|Coffeinum|Anhydrous caffeine|Matena|1,3,7-trimethylxanthine|Caffeinum|Cafena|3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion	stay awake maximum strength|fi	DRUGBANK	DB00201	C8H10N4O2	small molecule	N06BC01|V04CG30	58-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RYYVLZVUVIJVGH-UHFFFAOYSA-N
4254	111309	5291	-	PIK3CB	P110BETA|PI3K|PI3KBETA|PIK3C1	9606	Homo sapiens	unknown	target	Foukas LC (2002)	12145276	174346	194	Caffeine	Cafine|1,3,7-trimethylpurine-2,6-dione|Theine|7-methyltheophylline|Coffein|Methyltheobromine|Koffein|Guaranine|1-methyltheobromine|Thein|tena|1,3,7-trimethyl-2,6-dioxopurine|Coffeinum|Anhydrous caffeine|Matena|1,3,7-trimethylxanthine|Caffeinum|Cafena|3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion	stay awake maximum strength|fi	DRUGBANK	DB00201	C8H10N4O2	small molecule	N06BC01|V04CG30	58-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RYYVLZVUVIJVGH-UHFFFAOYSA-N
4259	111308	5290	-	PIK3CA	CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha	9606	Homo sapiens	unknown	target	Foukas LC (2002)	12145276	174346	194	Caffeine	Cafine|1,3,7-trimethylpurine-2,6-dione|Theine|7-methyltheophylline|Coffein|Methyltheobromine|Koffein|Guaranine|1-methyltheobromine|Thein|tena|1,3,7-trimethyl-2,6-dioxopurine|Coffeinum|Anhydrous caffeine|Matena|1,3,7-trimethylxanthine|Caffeinum|Cafena|3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion	stay awake maximum strength|fi	DRUGBANK	DB00201	C8H10N4O2	small molecule	N06BC01|V04CG30	58-08-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RYYVLZVUVIJVGH-UHFFFAOYSA-N
5619	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	inducer	target	Ruderman NB (2003)	14500570	175273	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZWYZXLIPXDOLR-UHFFFAOYSA-N
5620	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	inducer	target	Kovacic S (2003)	12890675	175276	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZWYZXLIPXDOLR-UHFFFAOYSA-N
5621	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	inducer	target	Vucicevic L (2009)	19428322	175277	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZWYZXLIPXDOLR-UHFFFAOYSA-N
5622	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	inducer	target	Leverve XM (2003)	14502105	175274	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZWYZXLIPXDOLR-UHFFFAOYSA-N
5623	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	inducer	target	Leclerc I (2004)	14871885	175275	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZWYZXLIPXDOLR-UHFFFAOYSA-N
5624	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	inducer	target	Hardie DG (2003)	12960015	175278	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZWYZXLIPXDOLR-UHFFFAOYSA-N
5625	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	inducer	target	Towler MC (2007)	17307971	175279	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZWYZXLIPXDOLR-UHFFFAOYSA-N
5626	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	inducer	target	Musi N (2002)	12086935	175280	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XZWYZXLIPXDOLR-UHFFFAOYSA-N
5758	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	potentiator	target	Reitamo S (2002)	12113647	175334	329	Pimecrolimus	Pimecrolimusum|Pimecrolimus|33-Epi-chloro-33-desoxyascomycin	elidel	DRUGBANK	DB00337	C43H68ClNO11	small molecule	D11AH02	137071-32-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KASDHRXLYQOAKZ-XDSKOBMDSA-N
5759	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	potentiator	target	Reitamo S (2002)	12113647	175334	329	Pimecrolimus	Pimecrolimusum|Pimecrolimus|33-Epi-chloro-33-desoxyascomycin	elidel	DRUGBANK	DB00337	C43H68ClNO11	small molecule	D11AH02	137071-32-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KASDHRXLYQOAKZ-XDSKOBMDSA-N
6501	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Lu X (2010)	20812347	175817	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6502	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6503	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Kim S (2007)	17575107	175827	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6504	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Eisen T (2006)	16880785	175826	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6505	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Haluska FG (2006)	16901402	175825	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
6506	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Flaherty KT (2006)	16609060	175828	390	Sorafenib	N-(4-Chloro-3-(trifluoromethyl)phenyl)-n'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea|Sorafenibum|4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide	nexavar	DRUGBANK	DB00398	C21H16ClF3N4O3	small molecule	L01XE05	284461-73-0	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLDQJTXFUGDVEO-UHFFFAOYSA-N
7385	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	inhibitor	target	Kulp SK (2004)	14973075	176389	474	Celecoxib	P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide|Celecoxibum|Celecoxib|Celebrex|Clcoxib	lupin-celecoxib|bio-celecoxib|	DRUGBANK	DB00482	C17H14F3N3O2S	small molecule	L01XX33|M01AH01	169590-42-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RZEKVGVHFLEQIL-UHFFFAOYSA-N
7386	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	inhibitor	target	Tong Z (2005)	16060857	176390	474	Celecoxib	P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide|Celecoxibum|Celecoxib|Celebrex|Clcoxib	lupin-celecoxib|bio-celecoxib|	DRUGBANK	DB00482	C17H14F3N3O2S	small molecule	L01XX33|M01AH01	169590-42-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RZEKVGVHFLEQIL-UHFFFAOYSA-N
7387	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	inhibitor	target	Li J (2006)	16455452	176391	474	Celecoxib	P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide|Celecoxibum|Celecoxib|Celebrex|Clcoxib	lupin-celecoxib|bio-celecoxib|	DRUGBANK	DB00482	C17H14F3N3O2S	small molecule	L01XX33|M01AH01	169590-42-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RZEKVGVHFLEQIL-UHFFFAOYSA-N
7388	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	inhibitor	target	Zhu J (2004)	15205346	176392	474	Celecoxib	P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide|Celecoxibum|Celecoxib|Celebrex|Clcoxib	lupin-celecoxib|bio-celecoxib|	DRUGBANK	DB00482	C17H14F3N3O2S	small molecule	L01XX33|M01AH01	169590-42-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RZEKVGVHFLEQIL-UHFFFAOYSA-N
7389	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	inhibitor	target	Tseng PH (2006)	16887935	176393	474	Celecoxib	P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide|Celecoxibum|Celecoxib|Celebrex|Clcoxib	lupin-celecoxib|bio-celecoxib|	DRUGBANK	DB00482	C17H14F3N3O2S	small molecule	L01XX33|M01AH01	169590-42-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RZEKVGVHFLEQIL-UHFFFAOYSA-N
8550	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inhibitor	target	Rice PL (2001)	11245463	177238	595	Sulindac	cis-5-Fluoro-2-methyl-1-((P-methylsulfinyl)benzylidene)indene-3-acetic acid|Sulindac|Clinoril|Sulindaco|(Z)-5-Fluoro-2-methyl-1-((P-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|Sulindacum	sulindac|clinoril tab 150mg|ap	DRUGBANK	DB00605	C20H17FO3S	small molecule	M01AB02	38194-50-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLKXDPUZXIRXEP-MFOYZWKCSA-N
8551	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inhibitor	target	Rice PL (2004)	15548677	177239	595	Sulindac	cis-5-Fluoro-2-methyl-1-((P-methylsulfinyl)benzylidene)indene-3-acetic acid|Sulindac|Clinoril|Sulindaco|(Z)-5-Fluoro-2-methyl-1-((P-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|Sulindacum	sulindac|clinoril tab 150mg|ap	DRUGBANK	DB00605	C20H17FO3S	small molecule	M01AB02	38194-50-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLKXDPUZXIRXEP-MFOYZWKCSA-N
8552	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inhibitor	target	Rice PL (2003)	12566304	177235	595	Sulindac	cis-5-Fluoro-2-methyl-1-((P-methylsulfinyl)benzylidene)indene-3-acetic acid|Sulindac|Clinoril|Sulindaco|(Z)-5-Fluoro-2-methyl-1-((P-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|Sulindacum	sulindac|clinoril tab 150mg|ap	DRUGBANK	DB00605	C20H17FO3S	small molecule	M01AB02	38194-50-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLKXDPUZXIRXEP-MFOYZWKCSA-N
8553	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inhibitor	target	Pangburn HA (2005)	16138927	177236	595	Sulindac	cis-5-Fluoro-2-methyl-1-((P-methylsulfinyl)benzylidene)indene-3-acetic acid|Sulindac|Clinoril|Sulindaco|(Z)-5-Fluoro-2-methyl-1-((P-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|Sulindacum	sulindac|clinoril tab 150mg|ap	DRUGBANK	DB00605	C20H17FO3S	small molecule	M01AB02	38194-50-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLKXDPUZXIRXEP-MFOYZWKCSA-N
8554	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inhibitor	target	Rice PL (2006)	16546990	177237	595	Sulindac	cis-5-Fluoro-2-methyl-1-((P-methylsulfinyl)benzylidene)indene-3-acetic acid|Sulindac|Clinoril|Sulindaco|(Z)-5-Fluoro-2-methyl-1-((P-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid|Sulindacum	sulindac|clinoril tab 150mg|ap	DRUGBANK	DB00605	C20H17FO3S	small molecule	M01AB02	38194-50-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MLKXDPUZXIRXEP-MFOYZWKCSA-N
11235	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	inhibitor	target	Masri M (2007)	17524933	178762	854	Tacrolimus	Tacrolimus anhydrous|Anhydrous tacrolimus|Tacrolimus, anhydrous	envarsus xr|advagraf|sandoz ta	DRUGBANK	DB00864	C44H69NO12	small molecule	L04AD02|D11AH01	104987-11-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QJJXYPPXXYFBGM-LFZNUXCKSA-N
11236	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	inhibitor	target	Labrande C (2005)	16289353	178761	854	Tacrolimus	Tacrolimus anhydrous|Anhydrous tacrolimus|Tacrolimus, anhydrous	envarsus xr|advagraf|sandoz ta	DRUGBANK	DB00864	C44H69NO12	small molecule	L04AD02|D11AH01	104987-11-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QJJXYPPXXYFBGM-LFZNUXCKSA-N
11347	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Sehgal SN (2003)	12742462	178847	867	Sirolimus	(-)-Rapamycin|Rapamycin	rapamune oral solution|sirolim	DRUGBANK	DB00877	C51H79NO13	small molecule	L04AA10|S01XA23	53123-88-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QFJCIRLUMZQUOT-KLHQEZAJSA-N
11348	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Chen X (2002)	11752352	171740	867	Sirolimus	(-)-Rapamycin|Rapamycin	rapamune oral solution|sirolim	DRUGBANK	DB00877	C51H79NO13	small molecule	L04AA10|S01XA23	53123-88-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QFJCIRLUMZQUOT-KLHQEZAJSA-N
11350	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Sehgal SN (2003)	12742462	178847	867	Sirolimus	(-)-Rapamycin|Rapamycin	rapamune oral solution|sirolim	DRUGBANK	DB00877	C51H79NO13	small molecule	L04AA10|S01XA23	53123-88-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QFJCIRLUMZQUOT-KLHQEZAJSA-N
11351	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	867	Sirolimus	(-)-Rapamycin|Rapamycin	rapamune oral solution|sirolim	DRUGBANK	DB00877	C51H79NO13	small molecule	L04AA10|S01XA23	53123-88-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QFJCIRLUMZQUOT-KLHQEZAJSA-N
11352	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Dowling RJ (2010)	20005306	178848	867	Sirolimus	(-)-Rapamycin|Rapamycin	rapamune oral solution|sirolim	DRUGBANK	DB00877	C51H79NO13	small molecule	L04AA10|S01XA23	53123-88-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QFJCIRLUMZQUOT-KLHQEZAJSA-N
11353	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Shuuin T (2009)	19620795	178849	867	Sirolimus	(-)-Rapamycin|Rapamycin	rapamune oral solution|sirolim	DRUGBANK	DB00877	C51H79NO13	small molecule	L04AA10|S01XA23	53123-88-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QFJCIRLUMZQUOT-KLHQEZAJSA-N
11869	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	activator	target	Zhang L (2007)	17369473	179062	904	Phenformin	DBI|Fenformin|Phenformine|-Phenethybiguanide|Fenformina|Phenforminum	-	DRUGBANK	DB00914	C10H15N5	small molecule	A10BD01|A10BA01	114-86-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ICFJFFQQTFMIBG-UHFFFAOYSA-N
11870	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	activator	target	Chen S (2008)	17995453	179061	904	Phenformin	DBI|Fenformin|Phenformine|-Phenethybiguanide|Fenformina|Phenforminum	-	DRUGBANK	DB00914	C10H15N5	small molecule	A10BD01|A10BA01	114-86-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ICFJFFQQTFMIBG-UHFFFAOYSA-N
11871	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	activator	target	Woollhead AM (2007)	17603555	179060	904	Phenformin	DBI|Fenformin|Phenformine|-Phenethybiguanide|Fenformina|Phenforminum	-	DRUGBANK	DB00914	C10H15N5	small molecule	A10BD01|A10BA01	114-86-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ICFJFFQQTFMIBG-UHFFFAOYSA-N
12158	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	activator	target	Din FV (2012)	22406476	179247	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12159	111551	5564	-	PRKAB1	AMPK|HAMPKb	9606	Homo sapiens	activator	target	Hawley SA (2012)	22517326	179246	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12160	111552	5565	-	PRKAB2	-	9606	Homo sapiens	activator	target	Din FV (2012)	22406476	179247	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12161	111552	5565	-	PRKAB2	-	9606	Homo sapiens	activator	target	Hawley SA (2012)	22517326	179246	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12162	119791	53632	-	PRKAG3	AMPKG3	9606	Homo sapiens	activator	target	Din FV (2012)	22406476	179247	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12163	119791	53632	-	PRKAG3	AMPKG3	9606	Homo sapiens	activator	target	Hawley SA (2012)	22517326	179246	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12164	111550	5563	-	PRKAA2	AMPK|AMPK2|AMPKa2|PRKAA	9606	Homo sapiens	activator	target	Din FV (2012)	22406476	179247	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12165	111550	5563	-	PRKAA2	AMPK|AMPK2|AMPKa2|PRKAA	9606	Homo sapiens	activator	target	Hawley SA (2012)	22517326	179246	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12166	111558	5571	-	PRKAG1	AMPKG	9606	Homo sapiens	activator	target	Din FV (2012)	22406476	179247	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12167	111558	5571	-	PRKAG1	AMPKG	9606	Homo sapiens	activator	target	Hawley SA (2012)	22517326	179246	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12168	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	activator	target	Din FV (2012)	22406476	179247	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12169	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	activator	target	Hawley SA (2012)	22517326	179246	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12170	119531	51422	-	PRKAG2	AAKG|AAKG2|CMH6|H91620p|WPWS	9606	Homo sapiens	activator	target	Din FV (2012)	22406476	179247	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12171	119531	51422	-	PRKAG2	AAKG|AAKG2|CMH6|H91620p|WPWS	9606	Homo sapiens	activator	target	Hawley SA (2012)	22517326	179246	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12183	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	unknown	target	Stevenson MA (1999)	10553090	179248	935	Acetylsalicylic acid	2-Acetoxybenzenecarboxylic acid|cido acetilsaliclico|Polopiryna|Easprin|Azetylsalizylsaeure|Salicylic acid acetate|2-Acetoxybenzoic acid|Acide actylsalicylique|O-acetylsalicylic acid|ASA|Acide 2-(acetyloxy)benzoique|Acetylsalicylsaeure|Acetylsalicylic acid|o-acetoxybenzoic acid|Azetylsalizylsure|2-(ACETYLOXY)benzoic acid|Acidum acetylsalicylicum|Acetylsalicylate|o-carboxyphenyl acetate|Aspirin	medique medi seltzer|asatab 80	DRUGBANK	DB00945	C9H8O4	small molecule	N02BA51|A01AD05|B01AC06|C10BX06|N02BA71|B01AC56|C10BX01|C10BX02|C10BX05|C10BX04|M01BA03|C10BX08|N02BA01	50-78-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
12802	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	inhibitor	target	Yao JS (2004)	15256478	179704	1007	Minocycline	Minocyclinum|Minocyclin|Minociclina|7-Dimethylamino-6-demethyl-6-deoxytetracycline|Minociclinum|(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide	solodyn|phl-minocycline|apo-mi	DRUGBANK	DB01017	C23H27N3O7	small molecule	J01AA08|A01AB23	10118-90-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DYKFCLLONBREIL-KVUCHLLUSA-N
12803	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	inhibitor	target	Sasamura H (2002)	11875741	179702	1007	Minocycline	Minocyclinum|Minocyclin|Minociclina|7-Dimethylamino-6-demethyl-6-deoxytetracycline|Minociclinum|(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide	solodyn|phl-minocycline|apo-mi	DRUGBANK	DB01017	C23H27N3O7	small molecule	J01AA08|A01AB23	10118-90-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DYKFCLLONBREIL-KVUCHLLUSA-N
12804	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	inhibitor	target	Rocchetti R (2005)	16224178	179703	1007	Minocycline	Minocyclinum|Minocyclin|Minociclina|7-Dimethylamino-6-demethyl-6-deoxytetracycline|Minociclinum|(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide	solodyn|phl-minocycline|apo-mi	DRUGBANK	DB01017	C23H27N3O7	small molecule	J01AA08|A01AB23	10118-90-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DYKFCLLONBREIL-KVUCHLLUSA-N
13351	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15381832	179935	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13352	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Slomiany BL (2005)	15985706	179934	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13353	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15527548	179937	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13354	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Machida K (2005)	15618457	179936	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13355	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15110780	179938	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13356	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inducer	target	Dubey RK (2004)	15292328	179944	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13357	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inducer	target	Oudit GY (2003)	12963636	179940	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13358	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inducer	target	Vaniotis G (2011)	20732414	179941	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13359	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inducer	target	Azzi M (2003)	13679574	179942	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13360	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inducer	target	Yeh CK (2005)	15689414	179943	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13361	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inducer	target	Adissu HA (2004)	15138589	179939	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13362	111314	5296	-	PIK3R2	MPPH|MPPH1|P85B|p85|p85-BETA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15381832	179935	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13363	111314	5296	-	PIK3R2	MPPH|MPPH1|P85B|p85|p85-BETA	9606	Homo sapiens	agonist	target	Slomiany BL (2005)	15985706	179934	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13364	111314	5296	-	PIK3R2	MPPH|MPPH1|P85B|p85|p85-BETA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15527548	179937	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13365	111314	5296	-	PIK3R2	MPPH|MPPH1|P85B|p85|p85-BETA	9606	Homo sapiens	agonist	target	Machida K (2005)	15618457	179936	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13366	111314	5296	-	PIK3R2	MPPH|MPPH1|P85B|p85|p85-BETA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15110780	179938	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13369	114075	8503	RP4-533D7.2	PIK3R3	p55|p55-GAMMA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15381832	179935	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13370	114075	8503	RP4-533D7.2	PIK3R3	p55|p55-GAMMA	9606	Homo sapiens	agonist	target	Slomiany BL (2005)	15985706	179934	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13371	114075	8503	RP4-533D7.2	PIK3R3	p55|p55-GAMMA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15527548	179937	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13372	114075	8503	RP4-533D7.2	PIK3R3	p55|p55-GAMMA	9606	Homo sapiens	agonist	target	Machida K (2005)	15618457	179936	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13373	114075	8503	RP4-533D7.2	PIK3R3	p55|p55-GAMMA	9606	Homo sapiens	agonist	target	Slomiany BL (2004)	15110780	179938	1052	Isoprenaline	(+-)-Isoprenaline|Isoproterenol|Isoprenalina|N-isopropyl--dihydroxyphenyl--hydroxyethylamine|(+-)-Isoproterenol|N-Isopropyl-beta-dihydroxyphenyl-beta-hydroxyethylamine|Isoprenaline|Isopropyl noradrenaline|alpha-(Isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-(isopropylamino)ethanol|()-isoprenaline|Isoprenalinum|N-Isopropylnorepinephrine|()-isoproterenol|3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol|-(isopropylaminomethyl)protocatechuyl alcohol|1-(3,4-Dihydroxyphenyl)-2-isopropylaminoethanol|N-Isopropylnoradrenaline	isuprel mistometer aem 0.25%|i	DRUGBANK	DB01064	C11H17NO3	small molecule	R03AK02|R03AB02|C01CA02|R03CB01|R03CB51	7683-59-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JWZZKOKVBUJMES-UHFFFAOYSA-N
13961	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Mamputu JC (2004)	14746574	180261	1108	Gliclazide	1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea|Gliclazida|1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea|Gliclazidum|N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea	sandoz gliclazide|glic|nu-glic	DRUGBANK	DB01120	C15H21N3O3S	small molecule	A10BB09	21187-98-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BOVGTQGAOIONJV-BETUJISGNA-N
13962	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Kimura T (2007)	17602961	180260	1108	Gliclazide	1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea|Gliclazida|1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea|Gliclazidum|N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea	sandoz gliclazide|glic|nu-glic	DRUGBANK	DB01120	C15H21N3O3S	small molecule	A10BB09	21187-98-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BOVGTQGAOIONJV-BETUJISGNA-N
13963	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Mamputu JC (2002)	12126787	180263	1108	Gliclazide	1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea|Gliclazida|1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea|Gliclazidum|N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea	sandoz gliclazide|glic|nu-glic	DRUGBANK	DB01120	C15H21N3O3S	small molecule	A10BB09	21187-98-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BOVGTQGAOIONJV-BETUJISGNA-N
13964	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Li L (2006)	17046555	180262	1108	Gliclazide	1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea|Gliclazida|1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea|Gliclazidum|N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea	sandoz gliclazide|glic|nu-glic	DRUGBANK	DB01120	C15H21N3O3S	small molecule	A10BB09	21187-98-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BOVGTQGAOIONJV-BETUJISGNA-N
14066	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	de Boer RA (2001)	11378004	180311	1124	Carvedilol	(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol|Carvedilolum|SKF 105517|Carvedilol	novo-carvedilol tablets|mylan-	DRUGBANK	DB01136	C24H26N2O4	small molecule	C07AG02	72956-09-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OGHNVEJMJSYVRP-UHFFFAOYSA-N
14067	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Shyu KG (2005)	15732037	180310	1124	Carvedilol	(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol|Carvedilolum|SKF 105517|Carvedilol	novo-carvedilol tablets|mylan-	DRUGBANK	DB01136	C24H26N2O4	small molecule	C07AG02	72956-09-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OGHNVEJMJSYVRP-UHFFFAOYSA-N
14068	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Shyu KG (2005)	15942707	180313	1124	Carvedilol	(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol|Carvedilolum|SKF 105517|Carvedilol	novo-carvedilol tablets|mylan-	DRUGBANK	DB01136	C24H26N2O4	small molecule	C07AG02	72956-09-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OGHNVEJMJSYVRP-UHFFFAOYSA-N
14069	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Saijonmaa O (2004)	15071347	180312	1124	Carvedilol	(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol|Carvedilolum|SKF 105517|Carvedilol	novo-carvedilol tablets|mylan-	DRUGBANK	DB01136	C24H26N2O4	small molecule	C07AG02	72956-09-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OGHNVEJMJSYVRP-UHFFFAOYSA-N
14084	109338	3091	-	HIF1A	HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78	9606	Homo sapiens	modulator	target	Shyu KG (2005)	15732037	180310	1124	Carvedilol	(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol|Carvedilolum|SKF 105517|Carvedilol	novo-carvedilol tablets|mylan-	DRUGBANK	DB01136	C24H26N2O4	small molecule	C07AG02	72956-09-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OGHNVEJMJSYVRP-UHFFFAOYSA-N
14403	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inducer	target	Dong Z (2002)	12426127	180438	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14404	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inducer	target	He Z (2003)	12529330	180442	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14405	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	inducer	target	Tsou TC (2005)	16239170	180445	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14406	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	inducer	target	Fauconneau B (2002)	12472888	180444	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14407	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	inducer	target	Ivanov VN (2005)	15580309	180446	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14408	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	inducer	target	Wang ZX (2005)	15916724	180443	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14409	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	inducer	target	He Z (2003)	12529330	180442	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14411	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inducer	target	Fauconneau B (2002)	12472888	180444	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14412	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inducer	target	Tanaka-Kagawa T (2003)	14674888	180447	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14413	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inducer	target	Jung DK (2003)	14516795	180449	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14414	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inducer	target	Mousa SA (2007)	17158527	180448	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
14415	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inducer	target	Felix K (2005)	15849723	180450	1157	Arsenic trioxide	Arsenicum album|Arsenious Acid|White arsenic|Arsenigen Saure|Arseni Trioxydum|Arsenious Acid Anhydride|Arsentrioxide|Arseneous anhydride|Anhydride Arsenieux|Arsenic(III) oxide|Arseneous oxide|Oxyde Arsenieux|Acide Arsenieux|Tetraarsenic hexaoxide|Arsenic Oxidearsenous Trioxide|Arsenic oxide|Arsenolite|Arsenic sesquioxide|Diarsenic trioxide|Arsenic Blanc|Arsenious Trioxide	trisenox	DRUGBANK	DB01169	As2O3	small molecule	L01XX27	1327-53-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MOQADKPFYVWPSE-UHFFFAOYSA-N
15606	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Ferrara N (2006)	17031284	180966	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15607	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Gaudreault J (2007)	18046235	180967	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15608	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Kourlas H (2007)	18035187	180964	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15609	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Spitzer MS (2008)	19668384	180965	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15610	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Pieramici DJ (2006)	17049020	180962	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15611	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Nguyen QD (2006)	17046701	180963	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15612	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Michels S (2005)	15973626	180960	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15613	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Rosenfeld PJ (2006)	16935211	180961	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15614	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Gaudreault J (2005)	15671306	180959	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
15615	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Bakri SJ (2007)	18054637	180958	1257	Ranibizumab	rhuFab V2	lucentis	DRUGBANK	DB01270	C2158H3282N562O681S12	biologic	S01LA04	347396-82-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
17203	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	1529	Everolimus	40-O-(2-hydroxyethyl)-rapamycin	afinitor|afinitor disperz|zort	DRUGBANK	DB01590	C53H83NO14	small molecule	L04AA18|L01XE10	159351-69-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKVAMNSJSFKALM-GKUWKFKPSA-N
17204	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Rostaing L (2010)	20155724	181558	1529	Everolimus	40-O-(2-hydroxyethyl)-rapamycin	afinitor|afinitor disperz|zort	DRUGBANK	DB01590	C53H83NO14	small molecule	L04AA18|L01XE10	159351-69-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKVAMNSJSFKALM-GKUWKFKPSA-N
17205	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	George S (2009)	19774211	181559	1529	Everolimus	40-O-(2-hydroxyethyl)-rapamycin	afinitor|afinitor disperz|zort	DRUGBANK	DB01590	C53H83NO14	small molecule	L04AA18|L01XE10	159351-69-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKVAMNSJSFKALM-GKUWKFKPSA-N
17206	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Ettenger R (2008)	18466433	181554	1529	Everolimus	40-O-(2-hydroxyethyl)-rapamycin	afinitor|afinitor disperz|zort	DRUGBANK	DB01590	C53H83NO14	small molecule	L04AA18|L01XE10	159351-69-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKVAMNSJSFKALM-GKUWKFKPSA-N
17207	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Coppin C (2010)	20531964	181555	1529	Everolimus	40-O-(2-hydroxyethyl)-rapamycin	afinitor|afinitor disperz|zort	DRUGBANK	DB01590	C53H83NO14	small molecule	L04AA18|L01XE10	159351-69-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKVAMNSJSFKALM-GKUWKFKPSA-N
17208	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Albert S (2010)	20569080	181556	1529	Everolimus	40-O-(2-hydroxyethyl)-rapamycin	afinitor|afinitor disperz|zort	DRUGBANK	DB01590	C53H83NO14	small molecule	L04AA18|L01XE10	159351-69-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKVAMNSJSFKALM-GKUWKFKPSA-N
17209	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Teachey DT (2009)	19344392	181557	1529	Everolimus	40-O-(2-hydroxyethyl)-rapamycin	afinitor|afinitor disperz|zort	DRUGBANK	DB01590	C53H83NO14	small molecule	L04AA18|L01XE10	159351-69-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKVAMNSJSFKALM-GKUWKFKPSA-N
17502	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1586	7-Methyl-Gpppa	P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE	-	DRUGBANK	DB01649	C21H30N10O17P3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QQOHNVHGNZYSBP-XPWFQUROSA-O
17503	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1586	7-Methyl-Gpppa	P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE	-	DRUGBANK	DB01649	C21H30N10O17P3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QQOHNVHGNZYSBP-XPWFQUROSA-O
17643	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1647	(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester	-	-	DRUGBANK	DB01712	C23H28N2O5S2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NDDSSAGSYFVBTG-SFTDATJTSA-N
17658	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1658	{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid	-	-	DRUGBANK	DB01723	C38H47NO11	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XCCRAOPQCACRFC-JBOQNHBVSA-N
17659	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1658	{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid	-	-	DRUGBANK	DB01723	C38H47NO11	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XCCRAOPQCACRFC-JBOQNHBVSA-N
17660	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1658	{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid	-	-	DRUGBANK	DB01723	C38H47NO11	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XCCRAOPQCACRFC-JBOQNHBVSA-N
17766	109842	3630	-	INS	IDDM|IDDM1|IDDM2|ILPR|IRDN|MODY10	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1709	M-Cresol	-	-	DRUGBANK	DB01776	C7H8O	small molecule	-	108-39-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RLSSMJSEOOYNOY-UHFFFAOYSA-N
17767	109842	3630	-	INS	IDDM|IDDM1|IDDM2|ILPR|IRDN|MODY10	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1709	M-Cresol	-	-	DRUGBANK	DB01776	C7H8O	small molecule	-	108-39-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RLSSMJSEOOYNOY-UHFFFAOYSA-N
17768	109842	3630	-	INS	IDDM|IDDM1|IDDM2|ILPR|IRDN|MODY10	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1709	M-Cresol	-	-	DRUGBANK	DB01776	C7H8O	small molecule	-	108-39-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	RLSSMJSEOOYNOY-UHFFFAOYSA-N
17958	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1793	Inositol 1,3,4,5-Tetrakisphosphate	-	-	DRUGBANK	DB01863	C6H16O18P4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CIPFCGZLFXVXBG-ZIQZFLOESA-N
17959	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1793	Inositol 1,3,4,5-Tetrakisphosphate	-	-	DRUGBANK	DB01863	C6H16O18P4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CIPFCGZLFXVXBG-ZIQZFLOESA-N
17966	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1793	Inositol 1,3,4,5-Tetrakisphosphate	-	-	DRUGBANK	DB01863	C6H16O18P4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CIPFCGZLFXVXBG-ZIQZFLOESA-N
17967	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1793	Inositol 1,3,4,5-Tetrakisphosphate	-	-	DRUGBANK	DB01863	C6H16O18P4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CIPFCGZLFXVXBG-ZIQZFLOESA-N
18022	109700	3479	-	IGF1	IGF-I|IGF1A|IGFI	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1817	N,N-bis(3-(D-gluconamido)propyl)deoxycholamide	Deoxy-bigchap	-	DRUGBANK	DB01890	C42H75N3O15	small molecule	-	86303-23-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OJSUWTDDXLCUFR-HGZMBBKESA-N
18023	109700	3479	-	IGF1	IGF-I|IGF1A|IGFI	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1817	N,N-bis(3-(D-gluconamido)propyl)deoxycholamide	Deoxy-bigchap	-	DRUGBANK	DB01890	C42H75N3O15	small molecule	-	86303-23-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OJSUWTDDXLCUFR-HGZMBBKESA-N
18024	109700	3479	-	IGF1	IGF-I|IGF1A|IGFI	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1817	N,N-bis(3-(D-gluconamido)propyl)deoxycholamide	Deoxy-bigchap	-	DRUGBANK	DB01890	C42H75N3O15	small molecule	-	86303-23-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OJSUWTDDXLCUFR-HGZMBBKESA-N
18090	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1858	7-Hydroxystaurosporine	-	-	DRUGBANK	DB01933	C28H26N4O4	small molecule	-	112953-11-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PBCZSGKMGDDXIJ-HQCWYSJUSA-N
18091	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1858	7-Hydroxystaurosporine	-	-	DRUGBANK	DB01933	C28H26N4O4	small molecule	-	112953-11-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PBCZSGKMGDDXIJ-HQCWYSJUSA-N
18135	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1870	3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	-	-	DRUGBANK	DB01946	C24H22N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UQHKJRCFSLMWIA-UHFFFAOYSA-N
18136	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1870	3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	-	-	DRUGBANK	DB01946	C24H22N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UQHKJRCFSLMWIA-UHFFFAOYSA-N
18137	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1870	3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	-	-	DRUGBANK	DB01946	C24H22N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UQHKJRCFSLMWIA-UHFFFAOYSA-N
18146	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1875	Gpi-1046	-	-	DRUGBANK	DB01951	C20H28N2O4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OQAHHWOPVDDWHD-INIZCTEOSA-N
18175	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1884	7n-Methyl-8-Hydroguanosine-5'-Diphosphate	-	-	DRUGBANK	DB01960	C11H19N5O11P2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QQODJOAVWUWVHJ-FCIPNVEPSA-N
18176	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1884	7n-Methyl-8-Hydroguanosine-5'-Diphosphate	-	-	DRUGBANK	DB01960	C11H19N5O11P2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QQODJOAVWUWVHJ-FCIPNVEPSA-N
18177	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	1884	7n-Methyl-8-Hydroguanosine-5'-Diphosphate	-	-	DRUGBANK	DB01960	C11H19N5O11P2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QQODJOAVWUWVHJ-FCIPNVEPSA-N
18324	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1934	Staurosporine	2GCD|BCPP000063|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-METHYLAMINO-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-09|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- (9CI)|ANTIBIOTIC AM-2282|EX-A1777|9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)-BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S-(9ALPHA,10BETA,11BETA,13ALPHA)-|HMS3650B17|NCGC00162400-06|H88EPA0A3N|8-METHOXY-9-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-16-OL|BRD-K17953061-001-02-8|62996-74-1|BRD-K17953061-001-11-9|109189-95-9|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8,10,12,14(28),15(19),20(27),21,23,25-NONAEN-16-ONE|1U59|CCG-208052|STAUROSPORINE & TUMOR NECROSIS FACTOR (TNF)|NCGC00162400-02|2DQ7|MEGXM0_000307|1NVR|STAUROSPORINE;9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)-|BRD-K17953061-001-05-1|NCGC00162400-03|7158-EP2289893A1|8,12-EPOXY-1H,8H-2,7B,12A-TRIAZADIBENZO(A,G)CYCLONONA(CDE)TRINDEN-1-ONE, 2,3,9,10,11,12-HEXAHYDRO-9-METHOXY-8-METHYL-10-(METHYLAMINO)-, (8ALPHA,9BETA,10BETA,12ALPHA)-(+)-|CGP 39360|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8(13),9,11,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|AM-2282|ANTIBIOTIC AM 2282|1XJD|STAUROSPORIN|STAUROSPORINE & TNF|7158-EP2311842A2|STAUROSPORIN, 4|DB02010|METHOXY-METHYL-(METHYLAMINO)[?]ONE|NCGC00162400-01|GNF-PF-1389|7158-EP2292617A1|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, [9S-(9ALPHA,10BETA,11BETA,13ALPHA)]-|ANTIBIOTIC 230|7158-EP2308855A1|ALKALOID AM-2282 FROM STREPTOMYCES|ST50826371|1STC|HY-15141|MOLMAP_000047|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-04|(+)-STAUROSPORINE|GTPL346|7158-EP2311809A1|Q5957181|CS-2716|STAUROSPORINE, 8|AKOS015897119|BIO1_000753|BRD-K17953061-001-04-4|SR-00000001485-4|STAUROSPORINE|7158-EP2308883A1|BRD-K17953061-001-10-1|NCGC00162400-05|[9S-(9?,10?,11?,13?)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE|LS-64042|CBIOL_001978|1SM2|1Q3D|BIO1_000264|1YHS|ZINC3814434|S1421|SR-00000001485|UNII-H88EPA0A3N|7158-EP2270008A1|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- & TUMOR NECROSIS FACTOR (TNF)|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO [12.12.2.1<2,6>.0<7,28>.0<8,13>.0<15,19>.0<20,27>.0<21,26>]NONACOSA-8(13),9,11 ,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|QTL1_000078|HMS1990J07|BIO1_001242|1XBC|DTXSID30911019|CCRIS 3272|BSPBIO_001146|BRD-K17953061-001-08-5|BDBM2579	-	DRUGBANK	DB02010	C28H26N4O3	small molecule	-	62996-74-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKSZLNNOFSGOKW-UCBFMKAXSA-N
18325	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1934	Staurosporine	2GCD|BCPP000063|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-METHYLAMINO-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-09|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- (9CI)|ANTIBIOTIC AM-2282|EX-A1777|9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)-BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S-(9ALPHA,10BETA,11BETA,13ALPHA)-|HMS3650B17|NCGC00162400-06|H88EPA0A3N|8-METHOXY-9-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-16-OL|BRD-K17953061-001-02-8|62996-74-1|BRD-K17953061-001-11-9|109189-95-9|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8,10,12,14(28),15(19),20(27),21,23,25-NONAEN-16-ONE|1U59|CCG-208052|STAUROSPORINE & TUMOR NECROSIS FACTOR (TNF)|NCGC00162400-02|2DQ7|MEGXM0_000307|1NVR|STAUROSPORINE;9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)-|BRD-K17953061-001-05-1|NCGC00162400-03|7158-EP2289893A1|8,12-EPOXY-1H,8H-2,7B,12A-TRIAZADIBENZO(A,G)CYCLONONA(CDE)TRINDEN-1-ONE, 2,3,9,10,11,12-HEXAHYDRO-9-METHOXY-8-METHYL-10-(METHYLAMINO)-, (8ALPHA,9BETA,10BETA,12ALPHA)-(+)-|CGP 39360|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8(13),9,11,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|AM-2282|ANTIBIOTIC AM 2282|1XJD|STAUROSPORIN|STAUROSPORINE & TNF|7158-EP2311842A2|STAUROSPORIN, 4|DB02010|METHOXY-METHYL-(METHYLAMINO)[?]ONE|NCGC00162400-01|GNF-PF-1389|7158-EP2292617A1|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, [9S-(9ALPHA,10BETA,11BETA,13ALPHA)]-|ANTIBIOTIC 230|7158-EP2308855A1|ALKALOID AM-2282 FROM STREPTOMYCES|ST50826371|1STC|HY-15141|MOLMAP_000047|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-04|(+)-STAUROSPORINE|GTPL346|7158-EP2311809A1|Q5957181|CS-2716|STAUROSPORINE, 8|AKOS015897119|BIO1_000753|BRD-K17953061-001-04-4|SR-00000001485-4|STAUROSPORINE|7158-EP2308883A1|BRD-K17953061-001-10-1|NCGC00162400-05|[9S-(9?,10?,11?,13?)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE|LS-64042|CBIOL_001978|1SM2|1Q3D|BIO1_000264|1YHS|ZINC3814434|S1421|SR-00000001485|UNII-H88EPA0A3N|7158-EP2270008A1|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- & TUMOR NECROSIS FACTOR (TNF)|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO [12.12.2.1<2,6>.0<7,28>.0<8,13>.0<15,19>.0<20,27>.0<21,26>]NONACOSA-8(13),9,11 ,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|QTL1_000078|HMS1990J07|BIO1_001242|1XBC|DTXSID30911019|CCRIS 3272|BSPBIO_001146|BRD-K17953061-001-08-5|BDBM2579	-	DRUGBANK	DB02010	C28H26N4O3	small molecule	-	62996-74-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKSZLNNOFSGOKW-UCBFMKAXSA-N
18338	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	1934	Staurosporine	2GCD|BCPP000063|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-METHYLAMINO-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-09|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- (9CI)|ANTIBIOTIC AM-2282|EX-A1777|9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)-BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S-(9ALPHA,10BETA,11BETA,13ALPHA)-|HMS3650B17|NCGC00162400-06|H88EPA0A3N|8-METHOXY-9-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-16-OL|BRD-K17953061-001-02-8|62996-74-1|BRD-K17953061-001-11-9|109189-95-9|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8,10,12,14(28),15(19),20(27),21,23,25-NONAEN-16-ONE|1U59|CCG-208052|STAUROSPORINE & TUMOR NECROSIS FACTOR (TNF)|NCGC00162400-02|2DQ7|MEGXM0_000307|1NVR|STAUROSPORINE;9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)-|BRD-K17953061-001-05-1|NCGC00162400-03|7158-EP2289893A1|8,12-EPOXY-1H,8H-2,7B,12A-TRIAZADIBENZO(A,G)CYCLONONA(CDE)TRINDEN-1-ONE, 2,3,9,10,11,12-HEXAHYDRO-9-METHOXY-8-METHYL-10-(METHYLAMINO)-, (8ALPHA,9BETA,10BETA,12ALPHA)-(+)-|CGP 39360|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8(13),9,11,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|AM-2282|ANTIBIOTIC AM 2282|1XJD|STAUROSPORIN|STAUROSPORINE & TNF|7158-EP2311842A2|STAUROSPORIN, 4|DB02010|METHOXY-METHYL-(METHYLAMINO)[?]ONE|NCGC00162400-01|GNF-PF-1389|7158-EP2292617A1|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, [9S-(9ALPHA,10BETA,11BETA,13ALPHA)]-|ANTIBIOTIC 230|7158-EP2308855A1|ALKALOID AM-2282 FROM STREPTOMYCES|ST50826371|1STC|HY-15141|MOLMAP_000047|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-04|(+)-STAUROSPORINE|GTPL346|7158-EP2311809A1|Q5957181|CS-2716|STAUROSPORINE, 8|AKOS015897119|BIO1_000753|BRD-K17953061-001-04-4|SR-00000001485-4|STAUROSPORINE|7158-EP2308883A1|BRD-K17953061-001-10-1|NCGC00162400-05|[9S-(9?,10?,11?,13?)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE|LS-64042|CBIOL_001978|1SM2|1Q3D|BIO1_000264|1YHS|ZINC3814434|S1421|SR-00000001485|UNII-H88EPA0A3N|7158-EP2270008A1|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- & TUMOR NECROSIS FACTOR (TNF)|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO [12.12.2.1<2,6>.0<7,28>.0<8,13>.0<15,19>.0<20,27>.0<21,26>]NONACOSA-8(13),9,11 ,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|QTL1_000078|HMS1990J07|BIO1_001242|1XBC|DTXSID30911019|CCRIS 3272|BSPBIO_001146|BRD-K17953061-001-08-5|BDBM2579	-	DRUGBANK	DB02010	C28H26N4O3	small molecule	-	62996-74-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKSZLNNOFSGOKW-UCBFMKAXSA-N
18339	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	1934	Staurosporine	2GCD|BCPP000063|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-METHYLAMINO-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-09|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- (9CI)|ANTIBIOTIC AM-2282|EX-A1777|9,13-EPOXY-1H,9H-DIINDOLO(1,2,3-GH:3',2',1'-LM)PYRROLO(3,4-J)(1,7)-BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S-(9ALPHA,10BETA,11BETA,13ALPHA)-|HMS3650B17|NCGC00162400-06|H88EPA0A3N|8-METHOXY-9-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-16-OL|BRD-K17953061-001-02-8|62996-74-1|BRD-K17953061-001-11-9|109189-95-9|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8,10,12,14(28),15(19),20(27),21,23,25-NONAEN-16-ONE|1U59|CCG-208052|STAUROSPORINE & TUMOR NECROSIS FACTOR (TNF)|NCGC00162400-02|2DQ7|MEGXM0_000307|1NVR|STAUROSPORINE;9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)-|BRD-K17953061-001-05-1|NCGC00162400-03|7158-EP2289893A1|8,12-EPOXY-1H,8H-2,7B,12A-TRIAZADIBENZO(A,G)CYCLONONA(CDE)TRINDEN-1-ONE, 2,3,9,10,11,12-HEXAHYDRO-9-METHOXY-8-METHYL-10-(METHYLAMINO)-, (8ALPHA,9BETA,10BETA,12ALPHA)-(+)-|CGP 39360|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]NONACOSA-8(13),9,11,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|AM-2282|ANTIBIOTIC AM 2282|1XJD|STAUROSPORIN|STAUROSPORINE & TNF|7158-EP2311842A2|STAUROSPORIN, 4|DB02010|METHOXY-METHYL-(METHYLAMINO)[?]ONE|NCGC00162400-01|GNF-PF-1389|7158-EP2292617A1|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, [9S-(9ALPHA,10BETA,11BETA,13ALPHA)]-|ANTIBIOTIC 230|7158-EP2308855A1|ALKALOID AM-2282 FROM STREPTOMYCES|ST50826371|1STC|HY-15141|MOLMAP_000047|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|NCGC00162400-04|(+)-STAUROSPORINE|GTPL346|7158-EP2311809A1|Q5957181|CS-2716|STAUROSPORINE, 8|AKOS015897119|BIO1_000753|BRD-K17953061-001-04-4|SR-00000001485-4|STAUROSPORINE|7158-EP2308883A1|BRD-K17953061-001-10-1|NCGC00162400-05|[9S-(9?,10?,11?,13?)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE|LS-64042|CBIOL_001978|1SM2|1Q3D|BIO1_000264|1YHS|ZINC3814434|S1421|SR-00000001485|UNII-H88EPA0A3N|7158-EP2270008A1|(5S,6R,7R,9R)-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9,15,16-HEXAHYDRO-5H,14H-17-OXA-4B,9A,15-TRIAZA-5,9-METHANODIBENZO[B,H]CYCLONONA[JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE|9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE, 2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-, (9S,10R,11R,13R)- & TUMOR NECROSIS FACTOR (TNF)|(2S,3R,4R,6R)-3-METHOXY-2-METHYL-4-(METHYLAMINO)-29-OXA-1,7,17-TRIAZAOCTACYCLO [12.12.2.1<2,6>.0<7,28>.0<8,13>.0<15,19>.0<20,27>.0<21,26>]NONACOSA-8(13),9,11 ,14(28),15(19),20(27),21(26),22,24-NONAEN-16-ONE|QTL1_000078|HMS1990J07|BIO1_001242|1XBC|DTXSID30911019|CCRIS 3272|BSPBIO_001146|BRD-K17953061-001-08-5|BDBM2579	-	DRUGBANK	DB02010	C28H26N4O3	small molecule	-	62996-74-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	HKSZLNNOFSGOKW-UCBFMKAXSA-N
18568	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2036	Olomoucine	-	-	DRUGBANK	DB02116	C15H18N6O	small molecule	-	101622-51-9	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GTVPOLSIJWJJNY-UHFFFAOYSA-N
18915	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2218	Methyl Methylsulfinylmethyl Sulfide	-	-	DRUGBANK	DB02311	C3H8OS2	small molecule	-	33577-16-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OTKFCIVOVKCFHR-ZCFIWIBFSA-N
18916	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2218	Methyl Methylsulfinylmethyl Sulfide	-	-	DRUGBANK	DB02311	C3H8OS2	small molecule	-	33577-16-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OTKFCIVOVKCFHR-ZCFIWIBFSA-N
18917	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2218	Methyl Methylsulfinylmethyl Sulfide	-	-	DRUGBANK	DB02311	C3H8OS2	small molecule	-	33577-16-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OTKFCIVOVKCFHR-ZCFIWIBFSA-N
18985	109338	3091	-	HIF1A	HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78	9606	Homo sapiens	unknown	target	Dai Y (2007)	17498737	181627	2247	2-Methoxyestradiol	2-Hydroxyestradol 2-methyl ether|2-MeOE2|2-methoxy-17beta-estradiol|2ME2|2-methoxyestra-1(10),2,4-triene-3,17-diol|2-Hydroxyestradiol 2-methyl ether|ESM|2-Methoxyestradiol-17beta	-	DRUGBANK	DB02342	C19H26O3	small molecule	-	362-07-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CQOQDQWUFQDJMK-WRWXEFHESA-N
18986	109338	3091	-	HIF1A	HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78	9606	Homo sapiens	unknown	target	Zhou D (2008)	17716391	181628	2247	2-Methoxyestradiol	2-Hydroxyestradol 2-methyl ether|2-MeOE2|2-methoxy-17beta-estradiol|2ME2|2-methoxyestra-1(10),2,4-triene-3,17-diol|2-Hydroxyestradiol 2-methyl ether|ESM|2-Methoxyestradiol-17beta	-	DRUGBANK	DB02342	C19H26O3	small molecule	-	362-07-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CQOQDQWUFQDJMK-WRWXEFHESA-N
19043	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2280	Myricetin	3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one|Cannabiscetin|3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one|Myricetol|3,5,7,3',4',5'-Hexahydroxyflavone|MYC|Myricitin|3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-one	-	DRUGBANK	DB02375	C15H10O8	small molecule	-	529-44-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	IKMDFBPHZNJCSN-UHFFFAOYSA-N
19044	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2280	Myricetin	3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one|Cannabiscetin|3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one|Myricetol|3,5,7,3',4',5'-Hexahydroxyflavone|MYC|Myricitin|3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-one	-	DRUGBANK	DB02375	C15H10O8	small molecule	-	529-44-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	IKMDFBPHZNJCSN-UHFFFAOYSA-N
19045	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2280	Myricetin	3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one|Cannabiscetin|3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one|Myricetol|3,5,7,3',4',5'-Hexahydroxyflavone|MYC|Myricitin|3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-one	-	DRUGBANK	DB02375	C15H10O8	small molecule	-	529-44-2	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	IKMDFBPHZNJCSN-UHFFFAOYSA-N
19284	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2380	Phosphonothreonine	-	-	DRUGBANK	DB02482	C4H10NO6P	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	USRGIUJOYOXOQJ-STHAYSLISA-N
19285	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2380	Phosphonothreonine	-	-	DRUGBANK	DB02482	C4H10NO6P	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	USRGIUJOYOXOQJ-STHAYSLISA-N
19286	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2380	Phosphonothreonine	-	-	DRUGBANK	DB02482	C4H10NO6P	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	USRGIUJOYOXOQJ-STHAYSLISA-N
19610	109700	3479	-	IGF1	IGF-I|IGF1A|IGFI	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2534	N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate	-	-	DRUGBANK	DB02643	C17H38NO3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	IZWSFJTYBVKZNK-UHFFFAOYSA-O
19632	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2547	2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One	-	-	DRUGBANK	DB02656	C19H17NO3	small molecule	-	154447-36-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CZQHHVNHHHRRDU-UHFFFAOYSA-N
19758	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2604	7-Methyl-Guanosine-5'-Triphosphate	-	-	DRUGBANK	DB02716	C11H19N5O14P3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DKVRNHPCAOHRSI-FCIPNVEPSA-O
19759	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2604	7-Methyl-Guanosine-5'-Triphosphate	-	-	DRUGBANK	DB02716	C11H19N5O14P3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DKVRNHPCAOHRSI-FCIPNVEPSA-O
19760	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2604	7-Methyl-Guanosine-5'-Triphosphate	-	-	DRUGBANK	DB02716	C11H19N5O14P3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DKVRNHPCAOHRSI-FCIPNVEPSA-O
19814	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	2621	Purvalanol	-	-	DRUGBANK	DB02733	C20H25ClN6O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKDXRFMOHZVXSG-HNNXBMFYSA-N
19818	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	2621	Purvalanol	-	-	DRUGBANK	DB02733	C20H25ClN6O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZKDXRFMOHZVXSG-HNNXBMFYSA-N
20076	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2768	FKB-001	-	-	DRUGBANK	DB02888	C35H42F2N2O6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NBYCDVVSYOMFMS-VMPREFPWSA-N
20077	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2768	FKB-001	-	-	DRUGBANK	DB02888	C35H42F2N2O6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NBYCDVVSYOMFMS-VMPREFPWSA-N
20078	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2768	FKB-001	-	-	DRUGBANK	DB02888	C35H42F2N2O6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NBYCDVVSYOMFMS-VMPREFPWSA-N
20456	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	2959	Pyroglutamic Acid	-	-	DRUGBANK	DB03088	C5H7NO3	small molecule	-	98-79-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ODHCTXKNWHHXJC-GSVOUGTGSA-N
20457	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	2959	Pyroglutamic Acid	-	-	DRUGBANK	DB03088	C5H7NO3	small molecule	-	98-79-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ODHCTXKNWHHXJC-GSVOUGTGSA-N
20458	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	2959	Pyroglutamic Acid	-	-	DRUGBANK	DB03088	C5H7NO3	small molecule	-	98-79-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ODHCTXKNWHHXJC-GSVOUGTGSA-N
21002	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3201	Heptyl-Beta-D-Glucopyranoside	-	-	DRUGBANK	DB03338	C13H26O6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NIDYWHLDTIVRJT-UJPOAAIJSA-N
21604	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3468	L-709,587	-	-	DRUGBANK	DB03621	C52H76N2O13	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	APSPCHLQXFEUHG-ZOQAXNDZSA-N
21605	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3468	L-709,587	-	-	DRUGBANK	DB03621	C52H76N2O13	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	APSPCHLQXFEUHG-ZOQAXNDZSA-N
21606	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3468	L-709,587	-	-	DRUGBANK	DB03621	C52H76N2O13	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	APSPCHLQXFEUHG-ZOQAXNDZSA-N
21863	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3596	Tris	Tromethamine|Tris(hydroxymethyl)aminomethane|THAM	sooryehan hyo fermented sun bl	DRUGBANK	DB03754	C4H11NO3	small molecule	-	77-86-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LENZDBCJOHFCAS-UHFFFAOYSA-N
21864	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3596	Tris	Tromethamine|Tris(hydroxymethyl)aminomethane|THAM	sooryehan hyo fermented sun bl	DRUGBANK	DB03754	C4H11NO3	small molecule	-	77-86-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LENZDBCJOHFCAS-UHFFFAOYSA-N
21865	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3596	Tris	Tromethamine|Tris(hydroxymethyl)aminomethane|THAM	sooryehan hyo fermented sun bl	DRUGBANK	DB03754	C4H11NO3	small molecule	-	77-86-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LENZDBCJOHFCAS-UHFFFAOYSA-N
21912	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3618	Rbt205 Inhibitor	-	-	DRUGBANK	DB03777	C25H24N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QMGUOJYZJKLOLH-UHFFFAOYSA-N
22383	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3846	(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine	-	-	DRUGBANK	DB04012	C18H26N2O5S2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GFEHACHKMVZGNQ-HOTGVXAUSA-N
22552	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3926	4-Hydroxy-2-Butanone	-	-	DRUGBANK	DB04094	C4H8O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LVSQXDHWDCMMRJ-UHFFFAOYSA-N
22553	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3926	4-Hydroxy-2-Butanone	-	-	DRUGBANK	DB04094	C4H8O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LVSQXDHWDCMMRJ-UHFFFAOYSA-N
22554	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3926	4-Hydroxy-2-Butanone	-	-	DRUGBANK	DB04094	C4H8O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LVSQXDHWDCMMRJ-UHFFFAOYSA-N
22636	111941	6009	-	RHEB	RHEB2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	3968	Guanosine-5'-Triphosphate	-	-	DRUGBANK	DB04137	C10H16N5O14P3	small molecule	-	86-01-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XKMLYUALXHKNFT-BZKDHIKHSA-N
22637	111941	6009	-	RHEB	RHEB2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	3968	Guanosine-5'-Triphosphate	-	-	DRUGBANK	DB04137	C10H16N5O14P3	small molecule	-	86-01-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XKMLYUALXHKNFT-BZKDHIKHSA-N
22638	111941	6009	-	RHEB	RHEB2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	3968	Guanosine-5'-Triphosphate	-	-	DRUGBANK	DB04137	C10H16N5O14P3	small molecule	-	86-01-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XKMLYUALXHKNFT-BZKDHIKHSA-N
22821	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4044	Quercetin	3,5,7,3',4'-Pentahydroxyflavone	-	DRUGBANK	DB04216	C15H10O7	small molecule	-	117-39-5	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	REFJWTPEDVJJIY-UHFFFAOYSA-N
23071	111941	6009	-	RHEB	RHEB2	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	4140	Guanosine-5'-Diphosphate	-	-	DRUGBANK	DB04315	C10H15N5O11P2	small molecule	-	146-91-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QGWNDRXFNXRZMB-BZKDHIKHSA-N
23072	111941	6009	-	RHEB	RHEB2	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	4140	Guanosine-5'-Diphosphate	-	-	DRUGBANK	DB04315	C10H15N5O11P2	small molecule	-	146-91-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QGWNDRXFNXRZMB-BZKDHIKHSA-N
23073	111941	6009	-	RHEB	RHEB2	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4140	Guanosine-5'-Diphosphate	-	-	DRUGBANK	DB04315	C10H15N5O11P2	small molecule	-	146-91-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QGWNDRXFNXRZMB-BZKDHIKHSA-N
23164	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4163	SB220025	-	-	DRUGBANK	DB04338	C18H19FN6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VSPFURGQAYMVAN-UHFFFAOYSA-N
23618	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Imming P (2006)	17016423	171742	4334	Phosphonoserine	-	-	DRUGBANK	DB04522	C3H8NO6P	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BZQFBWGGLXLEPQ-REOHCLBHSA-N
23619	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Overington JP (2006)	17139284	171741	4334	Phosphonoserine	-	-	DRUGBANK	DB04522	C3H8NO6P	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BZQFBWGGLXLEPQ-REOHCLBHSA-N
23766	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4413	5-iodotubercidin	-	-	DRUGBANK	DB04604	C11H13IN4O4	small molecule	-	24386-93-4	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	WHSIXKUPQCKWBY-IOSLPCCCSA-N
23866	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4554	Purvalanol A	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine|Purv	-	DRUGBANK	DB04751	C19H25ClN6O	small molecule	-	212844-53-6	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PMXCMJLOPOFPBT-HNNXBMFYSA-N
23875	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	4571	5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione	5-(6-QUINOXALINYLMETHYLENE)-2,4-THIAZOLIDINEDIONE|ZINC12504504|S1410|2A5U|SR-02000000919|GTPL6023|(5Z)-5-(QUINOXALIN-6-YLMETHYLIDENE)-1,3-THIAZOLIDINE-2,4-DIONE|ABP000101|AOB3848|AS605240|NCGC00261632-01|BCP9000323|5-QUINOXALIN-6-YLMETHYLENETHIAZOLIDINE-2,4-DIONE|BCP02097|CCG-101300|1287651-14-2|J-516278|HMS3650I15|AS 605240,5-(6-QUINOXALINYLMETHYLENE)-2,4-THIAZOLIDINE-2,4-DIONE|(Z)-5-(QUINOXALIN-6-YLMETHYLENE)THIAZOLIDINE-2,4-DIONE|AS 605240|HMS3262N16|SDCCGSBI-0086699.P002|TOX21_500947|AS-605240/AS605240|CC-118|LP00947|5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE|Q27088381|PI 3-KGAMMA INHIBITOR|QYT|648450-29-7|DB04769|SR-02000000919-2|HY-10109|5-[(QUINOXALIN-6-YL)METHYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE|BRD-K76773351-001-01-9|(5E)-5-(QUINOXALIN-6-YLMETHYLENE)-1,3-THIAZOLIDINE-2,4-DIONE|CS-0084|AS605240, >=98% (HPLC)|5-(6-QUINOXALINYLMETHYLENE)-2,4-THIAZOLIDINE-2,4-DIONE|5-(QUINOXALIN-6-YLMETHYLENE)THIAZOLIDINE-2,4-DIONE|SB19245|AKOS024457698|AS-16768|W-5475|NCGC00186030-01|AS-605240|PI 3-KG INHIBITOR|HMS3229I19|BDBM50324735	-	DRUGBANK	DB04769	C12H7N3O2S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SQWZFLMPDUSYGV-POHAHGRESA-N
24548	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Chen X (2002)	11752352	171740	5545	Temsirolimus	42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin|Torisel	gd-temsirolimus|torisel	DRUGBANK	DB06287	C56H87NO16	small molecule	L01XE09	162635-04-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CBPNZQVSJQDFBE-FUXHJELOSA-N
24549	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Radulovic S (2007)	17935273	182057	5545	Temsirolimus	42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin|Torisel	gd-temsirolimus|torisel	DRUGBANK	DB06287	C56H87NO16	small molecule	L01XE09	162635-04-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CBPNZQVSJQDFBE-FUXHJELOSA-N
24550	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor	target	Patard JJ (2008)	18265991	182064	5545	Temsirolimus	42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin|Torisel	gd-temsirolimus|torisel	DRUGBANK	DB06287	C56H87NO16	small molecule	L01XE09	162635-04-3	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CBPNZQVSJQDFBE-FUXHJELOSA-N
24824	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	inhibitor	target	Norrby K (2010)	21091776	182178	5634	Dalteparin	Daltepariininatrium|Dalteparinum Natricum|Dalteparinnatrium|Dalteparin sodn sl|Dalteparina sdica|Dalteparino natrio druska|Dalteparin Sodyum|Heparin Fragment KABI 2165|Dalteparyna sodowa|Daltparine sodique|Dalteparin sodium|Dalteparin-ntrium|Tedelparin	fragmin inj.-liq 2500 iu(anti-	DRUGBANK	DB06779	-	small molecule	B01AB04	9041-08-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24825	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	inhibitor	target	Marchetti M (2007)	17692905	182038	5634	Dalteparin	Daltepariininatrium|Dalteparinum Natricum|Dalteparinnatrium|Dalteparin sodn sl|Dalteparina sdica|Dalteparino natrio druska|Dalteparin Sodyum|Heparin Fragment KABI 2165|Dalteparyna sodowa|Daltparine sodique|Dalteparin sodium|Dalteparin-ntrium|Tedelparin	fragmin inj.-liq 2500 iu(anti-	DRUGBANK	DB06779	-	small molecule	B01AB04	9041-08-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24826	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	inhibitor	target	Takahashi H (2005)	16041398	181901	5634	Dalteparin	Daltepariininatrium|Dalteparinum Natricum|Dalteparinnatrium|Dalteparin sodn sl|Dalteparina sdica|Dalteparino natrio druska|Dalteparin Sodyum|Heparin Fragment KABI 2165|Dalteparyna sodowa|Daltparine sodique|Dalteparin sodium|Dalteparin-ntrium|Tedelparin	fragmin inj.-liq 2500 iu(anti-	DRUGBANK	DB06779	-	small molecule	B01AB04	9041-08-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
24852	111311	5293	RP11-558F24.3	PIK3CD	APDS|IMD14|P110DELTA|PI3K|p110D	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5652	2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE	-	-	DRUGBANK	DB06831	C21H15ClN6O2S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UMMYTDJYDSTEMB-UHFFFAOYSA-N
24853	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5652	2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE	-	-	DRUGBANK	DB06831	C21H15ClN6O2S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UMMYTDJYDSTEMB-UHFFFAOYSA-N
24860	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5657	N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE	-	-	DRUGBANK	DB06836	C14H16ClN3O4S2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	JFVNFXCESCXMBC-UHFFFAOYSA-N
24907	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5697	N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE	-	-	DRUGBANK	DB06877	C16H16N4O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OPBUUQBZKJSWTN-UHFFFAOYSA-N
24957	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5751	10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine	-	-	DRUGBANK	DB06932	C19H18N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NVINUNQBDNEMSY-UHFFFAOYSA-N
25012	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5817	N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide	-	-	DRUGBANK	DB06999	C17H14ClF2N3O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YZDJQTHVDDOVHR-UHFFFAOYSA-N
25013	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5818	N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide	-	-	DRUGBANK	DB07000	C21H16F2N4O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ILXJWLWSYAWJKZ-UHFFFAOYSA-N
25024	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5828	N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE	-	-	DRUGBANK	DB07010	C21H17ClN4O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PDJZASCRQRBYQS-UHFFFAOYSA-N
25046	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5851	5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE	-	-	DRUGBANK	DB07033	C14H12N2O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VWQVBIPGKIAUGA-QMMMGPOBSA-N
25077	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5891	5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one	-	-	DRUGBANK	DB07073	C13H18N2O2S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	DZXMARZBAUMWLK-UHFFFAOYSA-N
25142	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	5950	1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA	-	-	DRUGBANK	DB07132	C15H14N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KJDBLWKTHMHALD-QMMMGPOBSA-N
25276	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6080	(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE	-	-	DRUGBANK	DB07264	C22H17Cl2FN4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YMUYGRBBEDYUOP-HXUWFJFHSA-N
25308	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6116	2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine	-	-	DRUGBANK	DB07300	C19H19N5O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QSSGYSRUMIOURP-UHFFFAOYSA-N
25340	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6151	3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL	-	-	DRUGBANK	DB07335	C14H15N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	MWYBBCLGEHZSCP-UHFFFAOYSA-N
25472	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6267	3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE	-	-	DRUGBANK	DB07456	C27H26N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LBFDERUQORUFIN-QGZVFWFLSA-N
25473	111196	5170	-	PDPK1	PDK1|PDPK2|PDPK2P|PRO0461	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6268	3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE	-	-	DRUGBANK	DB07457	C23H20N4O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	APYXQTXFRIDSGE-UHFFFAOYSA-N
25525	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6314	(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE	-	-	DRUGBANK	DB07503	C11H5F2NO4S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SRLVNYDXMUGOFI-YWEYNIOJSA-N
25594	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6391	N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	-	-	DRUGBANK	DB07584	C15H13N7	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OKGCSZUKOGMZAL-UHFFFAOYSA-N
25596	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6392	5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine	-	-	DRUGBANK	DB07585	C12H11ClN6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YFFJXGRXFASBDL-UHFFFAOYSA-N
25816	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6587	(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE	-	-	DRUGBANK	DB07788	C19H22O7	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	NEQZWEXWOFPKOT-RCPUWQGCSA-N
25822	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6593	5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE	-	-	DRUGBANK	DB07794	C18H13N7	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XVECMUKVOMUNLE-UHFFFAOYSA-N
25835	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6610	N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide	-	-	DRUGBANK	DB07812	C20H18N4OS	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	TWYNGDRSMHRPSY-MRXNPFEDSA-N
25894	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6656	4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE	-	-	DRUGBANK	DB07859	C20H20ClN3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	LZMOSYUFVYJEPY-UHFFFAOYSA-N
25929	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6701	(1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione	-	-	DRUGBANK	DB07905	C19H22O8	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	SSNQAUBBJYCSMY-KNTMUCJRSA-N
25974	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6743	ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE	-	-	DRUGBANK	DB07947	C20H22ClN3O3S	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	AUHWQSZMVMMRLM-UHFFFAOYSA-N
26080	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6852	(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE	-	-	DRUGBANK	DB08059	C23H24O8	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QDLHCMPXEPAAMD-QAIWCSMKSA-N
26081	111308	5290	-	PIK3CA	CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6852	(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE	-	-	DRUGBANK	DB08059	C23H24O8	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QDLHCMPXEPAAMD-QAIWCSMKSA-N
26082	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6852	(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE	-	-	DRUGBANK	DB08059	C23H24O8	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	QDLHCMPXEPAAMD-QAIWCSMKSA-N
26101	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	6866	(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE	-	-	DRUGBANK	DB08073	C24H23N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	YWTBGJGMTBHQTM-IBGZPJMESA-N
26233	108292	1977	-	EIF4E	AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7008	2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL	-	-	DRUGBANK	DB08217	C9H17NOS	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	ZRRNXPDUICGIEB-UHFFFAOYSA-N
26248	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7021	MYRISTIC ACID	-	-	DRUGBANK	DB08231	C14H28O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	TUNFSRHWOTWDNC-UHFFFAOYSA-N
26267	109842	3630	-	INS	IDDM|IDDM1|IDDM2|ILPR|IRDN|MODY10	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7021	MYRISTIC ACID	-	-	DRUGBANK	DB08231	C14H28O2	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	TUNFSRHWOTWDNC-UHFFFAOYSA-N
26339	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7087	1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	-	-	DRUGBANK	DB08300	C16H13N5	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	UOKGZPYGRJDACN-UHFFFAOYSA-N
26552	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7292	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID	-	-	DRUGBANK	DB08513	C20H19N5O3	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	PAIQRYUOBBCBSE-UHFFFAOYSA-N
26569	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7298	(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE	-	-	DRUGBANK	DB08520	C24H39NO6	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	VUCSBBBCFXBFFY-IBGZPJMESA-N
26571	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7299	4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE	-	-	DRUGBANK	DB08521	C21H16FN3OS	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	CDMGBJANTYXAIV-HHHXNRCGSA-N
26596	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7331	(1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime	-	-	DRUGBANK	DB08553	C22H23N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	KWEFZSZCLBHIEQ-YYADALCUSA-N
26630	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7374	6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine	-	-	DRUGBANK	DB08597	C24H25N5O	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	XHBVYDAKJHETMP-UHFFFAOYSA-N
26694	109338	3091	-	HIF1A	HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78	9606	Homo sapiens	unknown	target	Berman HM (2000)	10592235	172122	7461	N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE	-	-	DRUGBANK	DB08687	C12H9ClN2O4	small molecule	-	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	OUQVKRKGTAUJQA-UHFFFAOYSA-N
26948	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Jordan EJ (2012)	23094782	182216	7625	Vemurafenib	Zelboraf|PLX4032|BRAF(V600E) Kinase Inhibitor RO5185426	zelboraf	DRUGBANK	DB08881	C23H18ClF2N3O3S	small molecule	L01XE15	918504-65-1	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	GPXBXXGIAQBQNI-UHFFFAOYSA-N
26951	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	binder	target	Browning DJ (2012)	22813448	182207	7629	Aflibercept	VEGF Trap|Ziv-Aflibercept|VEGF Trap-Eye	eylea|zaltrap	DRUGBANK	DB08885	C4318H6788N1164O1304S32	biologic	L01XX44|S01LA05	862111-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
26952	113266	7423	-	VEGFB	VEGFL|VRF	9606	Homo sapiens	binder	target	Browning DJ (2012)	22813448	182207	7629	Aflibercept	VEGF Trap|Ziv-Aflibercept|VEGF Trap-Eye	eylea|zaltrap	DRUGBANK	DB08885	C4318H6788N1164O1304S32	biologic	L01XX44|S01LA05	862111-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
26953	111249	5228	-	PGF	D12S1900|PGFL|PLGF|PlGF-2|SHGC-10760	9606	Homo sapiens	binder	target	Browning DJ (2012)	22813448	182207	7629	Aflibercept	VEGF Trap|Ziv-Aflibercept|VEGF Trap-Eye	eylea|zaltrap	DRUGBANK	DB08885	C4318H6788N1164O1304S32	biologic	L01XX44|S01LA05	862111-32-8	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	-
26991	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	inhibitor	target	Gibney GT (2013)	23621583	182249	7656	Dabrafenib	Dabrafenib|GSK2118436a	tafinlar	DRUGBANK	DB08912	C23H20F3N5O2S2	small molecule	L01XE23	-	DRUGBANK	-	-	-	-	-	-	-	-	-	-	-	BFSMGDJOXZAERB-UHFFFAOYSA-N
28025	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	Henning RK (2016)	26880702	211388	8425	Bivalent ligand 6	Bivalent_ligand_6|CPP-tri_a-PR	-	BIOGRID	-	-	polypeptidic	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: CPP-tri_a-PR(VHL:HIF1a peptide --- Akt:synthetic peptide)	-
28089	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Winter GE (2015)	25999370	211411	8410	Bivalent ligand 29	Bivalent_ligand_29|dFKBP-1|dFKBP-2|dFKBP-1/dFKBP-2	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: dFKBP-1/dFKBP-2(CRBN:thalidomide --- FKBP12:SLF)	-
28101	111313	5295	-	PIK3R1	AGM7|GRB1|IMD36|p85|p85-ALPHA	9606	Homo sapiens	degradation	target	Hines J (2013)	23674677	194582	8455	Bivalent ligand 35	Bivalent_ligand_35|ErbB2PPPI3K|phosphoPROTAC	-	BIOGRID	-	-	polypeptidic	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: ErbB2PPPI3K(VHL:HIF1alpha septapeptide --- PI3K:ErbB3 peptide)	-
28127	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	degradation	target	Buckley DL (2015)	26070106	211383	8438	Bivalent ligand 50	Bivalent_ligand_50|HaloPROTAC3	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	HaloPROTAC	PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety--linker--HaloTag binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited E3 ligase	Standardized BVL Name: HaloPROTAC3(VHL:degradation moiety B --- HaloTag7-ERK1)	-
28601	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	degradation	target	Smith BE (2019)	30631068	219514	8512	Bivalent ligand 72	SJFa PROTAC|Bivalent_ligand_72	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	SJFalpha PROTAC|Standardized BVL Name: (VHL:ligand 7 ---MAPK1:Foretinib)	-
28603	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	degradation	target	Smith BE (2019)	30631068	219514	8511	Bivalent ligand 73	SJFd PROTAC|Bivalent_ligand_73	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	SJFDelta PROTAC|Standardized BVL Name: (VHL:ligand 7 ---MAPK1:Foretinib)	-
28633	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Chen H (2019)	30901674	215477	8495	Bivalent ligand 87	Compound 2|Bivalent_ligand_87	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: Compound 2 (CRBN:pomalidomide ---BRAF: BRAF ligand)	-
28645	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Zhang X (2019)	31209349	220534	8545	Bivalent ligand 91	KB02-SLF|Bivalent_ligand_91	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	120224	54876	-	DCAF16	C4orf30	9606	Homo sapiens	recruited e3 ligase	small molecule|Standardized BVL Name: KB02-SLF (DCAF16:KB02 --- FKBP12:SLF)	-
28661	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Posternak G (2020)	32778845	223178	8501	Bivalent ligand 98	P4B|Bivalent_ligand_98	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: P4B(CRBN:pomalidomide --- BRAF:BI 882370)	-
28703	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Chen H (2019)	30901674	215477	8569	Bivalent ligand 116	compound 2|Bivalent_ligand_116	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 2 (CRBN:pomalidomide --- B-RAF:B-RAF ligand)	-
28727	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Huang HT (2018)	29129717	211728	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide --- ULK1:TL13-87)	-
28757	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Huang HT (2018)	29129717	211728	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide --- PRKAA1:TL13-87)	-
28781	111581	5595	-	MAPK3	ERK-1|ERK1|ERT2|HS44KDAP|HUMKER1A|P44ERK1|P44MAPK|PRKM3|p44-ERK1|p44-MAPK	9606	Homo sapiens	degradation	target	Lebraud H (2016)	28058282	223632	8531	Bivalent ligand 126	ERK-CLIPTAC|Bivalent_ligand_126	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	CLIPTAC	PROTAC variant formed in cells by click chemistry; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: ERK-CLIPTAC (CRBN:Tz-thalidomide --- MAPK3:Probe 1)	-
28783	111580	5594	-	MAPK1	ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK	9606	Homo sapiens	degradation	target	Lebraud H (2016)	28058282	223632	8531	Bivalent ligand 126	ERK-CLIPTAC|Bivalent_ligand_126	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	CLIPTAC	PROTAC variant formed in cells by click chemistry; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: ERK-CLIPTAC (CRBN:Tz-thalidomide --- MAPK1:Probe 1)	-
28895	118953	29904	-	EEF2K	HSU93850|eEF-2K	9606	Homo sapiens	degradation	target	Liu Y (2020)	32717479	223647	8565	Bivalent ligand 147	Compound 11|Bivalent_ligand_147	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: Compound 11l (CRBN:thalidomide --- EEF2K:A484954)	-
28899	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Simpson LM (2020)	32668203	223649	8567	Bivalent ligand 149	HaloPROTAC-E|Bivalent_ligand_149	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	HaloPROTAC	PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety--linker--HaloTag binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: HaloPROTAC-E (VHL:VH298 --- ULK1-GFP:GFP-HaloTag)	-
30025	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Reynders M (2020)	32128406	228703	9768	Bivalent ligand 177	PHOTAC-II-6|Bivalent_ligand_177	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Opto-PROTAC	PROTAC variant in which degradation activity can be regulated by exposure to light; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PHOTAC-II-6 (CRBN:thalidomide --- FKBP12:SLF)	-
30043	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Chen H (2019)	30901674	215477	9796	Bivalent ligand 184	Compound 2|Bivalent_ligand_184	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: Compound 2 (CRBN:pomalidomide --- BRAF: rigosertib)	-
30069	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Powell CE (2018)	29660984	228711	9756	Bivalent ligand 192	compound 9|Bivalent_ligand_192	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 9 (CRBN:pomalidomide --- RPS6KA1:TAE684)	-
30079	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Powell CE (2018)	29660984	228711	9755	Bivalent ligand 193	compound 11|Bivalent_ligand_193	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 11 (CRBN:pomalidomide --- RPS6KA1:ceritinib)	-
30161	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	degradation	target	You I (2020)	31859249	224930	9827	Bivalent ligand 213	INY-03-041|Bivalent_ligand_213	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-03-041 (CRBN:lenalidomide --- AKT1:GDC-0068)	-
30163	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	You I (2020)	31859249	224930	9827	Bivalent ligand 213	INY-03-041|Bivalent_ligand_213	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-03-041 (CRBN:lenalidomide --- AKT2:GDC-0068)	-
30165	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	degradation	target	You I (2020)	31859249	224930	9827	Bivalent ligand 213	INY-03-041|Bivalent_ligand_213	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-03-041 (CRBN:lenalidomide --- AKT3:GDC-0068)	-
30211	127480	153129	-	SLC38A9	-	9606	Homo sapiens	degradation	target	Bensimon A (2020)	32386596	223637	9832	Bivalent ligand 218	PROTAC dTAG13|Bivalent_ligand_218	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC dTAG13 (CRBN:phthalimide --- SLC38A9-FKBP12F36V:AP1867)	-
30321	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Alabi S (2021)	33568647	228724	9815	Bivalent ligand 253	SJF-0628|Bivalent_ligand_253	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SJF-0628 (VHL:HIF-1alpha hydroxyproline derived small molecule --- BRAF V600E mutant:vemurafenib)	-
30353	127480	153129	-	SLC38A9	-	9606	Homo sapiens	degradation	target	Bensimon A (2020)	32386596	223637	8519	Bivalent ligand 131	PROTAC dTAG7|Bivalent_ligand_131	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC dTAG7 (CRBN:phthalimide --- SLC38A9-FKBP12F36V:AP1867)	-
30528	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Takahashi D (2019)	31606272	239579	10004	Bivalent ligand 262	AUTAC2|Bivalent_ligand_262	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	AUTAC/ATTEC	Autophagosome Tethering Compound; structured as a LC3 autophagosome recruiting moiety--linker--target binding moiety; target degraded via autophagic degradation	123565	81631	-	MAP1LC3B	ATG8F|LC3B|MAP1A/1BLC3|MAP1LC3B-a	9606	Homo sapiens	autophagy-targeting protein	Standardized BVL Name: AUTAC2 (S-guanylation --- FKBP12:SLF)	-
30538	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- AKT2:TAE684)	-
30540	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- AKT3:TAE684)	-
30648	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- PRKAA1:TAE684)	-
30650	111550	5563	-	PRKAA2	AMPK|AMPK2|AMPKa2|PRKAA	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- PRKAA2:TAE684)	-
30660	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- RPS6KA1:TAE684)	-
30662	118144	27330	-	RPS6KA6	PP90RSK4|RSK4	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- RPS6KA6:TAE684)	-
30664	112112	6198	-	RPS6KB1	PS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alpha	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- RPS6KB1:TAE684)	-
30700	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- ULK1:TAE684)	-
30702	117470	25989	-	ULK3	-	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10010	Bivalent Ligand 264	SK-3-91|Bivalent_Ligand_264	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-91 (CRBN:pomalidomide--- ULK3:TAE684)	-
30760	118953	29904	-	EEF2K	HSU93850|eEF-2K	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide--- EEF2K:TAE684)	-
30806	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide--- PRKAA1:TAE684)	-
30812	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide--- RPS6KA1:TAE684)	-
30828	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide--- ULK1:TAE684)	-
30830	117470	25989	-	ULK3	-	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	8537	Bivalent ligand 120	TL12-186|Bivalent_ligand_120	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL12-186 (CRBN:pomalidomide--- ULK3:TAE684)	-
30916	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10011	Bivalent Ligand 267	DB0646|Bivalent_Ligand_267	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0646 (CRBN:Thalidomide--- RPS6KA3:GNF-7)	-
30932	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10011	Bivalent Ligand 267	DB0646|Bivalent_Ligand_267	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0646 (CRBN:Thalidomide--- ULK1:GNF-7)	-
31000	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10006	Bivalent Ligand 268	FMF-06-098-1|Bivalent_Ligand_268	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: FMF-06-098-1 (VHL:VHL-1--- PRKAA1:TAE)	-
31016	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10006	Bivalent Ligand 268	FMF-06-098-1|Bivalent_Ligand_268	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: FMF-06-098-1 (VHL:VHL-1--- ULK1:TAE)	-
31068	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10005	Bivalent Ligand 269	TMX-02-174|Bivalent_Ligand_269	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-174 (CRBN:pomalidomide--- PRKAA1:Ceritinib)	-
31070	111550	5563	-	PRKAA2	AMPK|AMPK2|AMPKa2|PRKAA	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10005	Bivalent Ligand 269	TMX-02-174|Bivalent_Ligand_269	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-174 (CRBN:pomalidomide--- PRKAA2:Ceritinib)	-
31076	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10005	Bivalent Ligand 269	TMX-02-174|Bivalent_Ligand_269	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-174 (CRBN:pomalidomide--- RPS6KA1:Ceritinib)	-
31078	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10005	Bivalent Ligand 269	TMX-02-174|Bivalent_Ligand_269	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-174 (CRBN:pomalidomide--- RPS6KA3:Ceritinib)	-
31146	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10035	Bivalent Ligand 270	DB0662|Bivalent_Ligand_270	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0662 (CRBN:thalidomide--- RPS6KA1:GNF-7)	-
31148	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10035	Bivalent Ligand 270	DB0662|Bivalent_Ligand_270	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0662 (CRBN:thalidomide--- RPS6KA3:GNF-7)	-
31158	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10035	Bivalent Ligand 270	DB0662|Bivalent_Ligand_270	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0662 (CRBN:thalidomide--- ULK1:GNF-7)	-
31206	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10036	Bivalent Ligand 271	TL13-97|Bivalent_Ligand_271	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-97 (CRBN:pomalidomide--- PRKAA1:Rebastinib)	-
31208	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10036	Bivalent Ligand 271	TL13-97|Bivalent_Ligand_271	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-97 (CRBN:pomalidomide--- RPS6KA1:Rebastinib)	-
31220	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10036	Bivalent Ligand 271	TL13-97|Bivalent_Ligand_271	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-97 (CRBN:pomalidomide--- ULK1:Rebastinib)	-
31222	117470	25989	-	ULK3	-	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10036	Bivalent Ligand 271	TL13-97|Bivalent_Ligand_271	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-97 (CRBN:pomalidomide--- ULK3:Rebastinib)	-
31338	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10034	Bivalent Ligand 273	DB1114|Bivalent_Ligand_273	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1114 (VHL:VHL-1--- RPS6KA1:GNF-7)	-
31348	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10034	Bivalent Ligand 273	DB1114|Bivalent_Ligand_273	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1114 (VHL:VHL-1--- ULK1:GNF-7)	-
31400	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10039	Bivalent Ligand 274	DB1113|Bivalent_Ligand_274	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1113 (VHL:VHL-1--- RPS6KA1:GNF-7)	-
31402	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10039	Bivalent Ligand 274	DB1113|Bivalent_Ligand_274	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1113 (VHL:VHL-1--- RPS6KA3:GNF-7)	-
31412	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10039	Bivalent Ligand 274	DB1113|Bivalent_Ligand_274	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB1113 (VHL:VHL-1--- ULK1:GNF-7)	-
31454	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10040	Bivalent Ligand 275	TMX-02-138|Bivalent_Ligand_275	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-138 (CRBN:pomalidomide--- PRKAA1:Ceritinib)	-
31456	111550	5563	-	PRKAA2	AMPK|AMPK2|AMPKa2|PRKAA	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10040	Bivalent Ligand 275	TMX-02-138|Bivalent_Ligand_275	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-138 (CRBN:pomalidomide--- PRKAA2:Ceritinib)	-
31460	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10040	Bivalent Ligand 275	TMX-02-138|Bivalent_Ligand_275	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-138 (CRBN:pomalidomide--- RPS6KA1:Ceritinib)	-
31462	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10040	Bivalent Ligand 275	TMX-02-138|Bivalent_Ligand_275	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-138 (CRBN:pomalidomide--- RPS6KA3:Ceritinib)	-
31506	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10037	Bivalent Ligand 276	MFH-5-126-1|Bivalent_Ligand_276	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MFH-5-126-1 (CRBN:pomalidomide--- PIK3CG:AT7519)	-
31556	112112	6198	-	RPS6KB1	PS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alpha	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10038	Bivalent Ligand 277	RSS0680|Bivalent_Ligand_277	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: RSS0680 (VHL:VHL-1--- RPS6KB1:Thienopyrimidines)	-
31608	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10041	Bivalent Ligand 278	SK-3-93|Bivalent_Ligand_278	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-93 (CRBN:Thalidomide--- PRKAA1:TAE684)	-
31612	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10041	Bivalent Ligand 278	SK-3-93|Bivalent_Ligand_278	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: SK-3-93 (CRBN:Thalidomide--- RPS6KA1:TAE684)	-
31660	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10042	Bivalent Ligand 279	DB0614|Bivalent_Ligand_279	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0614 (CRBN:Thalidomide--- ULK1:Thienopyrimidines)	-
31662	117470	25989	-	ULK3	-	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10042	Bivalent Ligand 279	DB0614|Bivalent_Ligand_279	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: DB0614 (CRBN:Thalidomide--- ULK3:Thienopyrimidines)	-
31706	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10067	Bivalent Ligand 283	LT2-49|Bivalent_Ligand_283	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: LT2-49 (CRBN:Thalidomide--- PRKAA1:TAE684)	-
31928	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10061	Bivalent Ligand 289	BSJ-04-178|Bivalent_Ligand_289	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-04-178 (CRBN:Thalidomide--- ULK1:MRT68921)	-
31960	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10089	Bivalent Ligand 290	TMX-01-160-1|Bivalent_Ligand_290	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-01-160-1 (CRBN:Thalidomide--- RPS6KA1:Ceritinib)	-
32098	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10086	Bivalent Ligand 295	RSS0628|Bivalent_Ligand_295	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: RSS0628 (CRBN:Thalidomide--- ULK1:Thienopyrimidines)	-
32100	117470	25989	-	ULK3	-	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10086	Bivalent Ligand 295	RSS0628|Bivalent_Ligand_295	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: RSS0628 (CRBN:Thalidomide--- ULK3:Thienopyrimidines)	-
32114	112112	6198	-	RPS6KB1	PS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alpha	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10087	Bivalent Ligand 296	BSJ-05-026|Bivalent_Ligand_296	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-05-026 (VHL:VHL-1--- RPS6KB1:MRT68921)	-
32126	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10087	Bivalent Ligand 296	BSJ-05-026|Bivalent_Ligand_296	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: BSJ-05-026 (VHL:VHL-1--- ULK1:MRT68921)	-
32146	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10088	Bivalent Ligand 297	TMX-02-172|Bivalent_Ligand_297	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-172 (CRBN:pomalidomide--- RPS6KA1:Ceritinib)	-
32148	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10088	Bivalent Ligand 297	TMX-02-172|Bivalent_Ligand_297	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TMX-02-172 (CRBN:pomalidomide--- RPS6KA3:Ceritinib)	-
32190	112112	6198	-	RPS6KB1	PS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alpha	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10084	Bivalent Ligand 299	JWG-123|Bivalent_Ligand_299	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: JWG-123 (VHL:VHL-1--- RPS6KB1:TG101209)	-
32308	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10018	Bivalent Ligand 305	MFH-5-103-1|Bivalent_Ligand_305	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MFH-5-103-1 (CRBN:pomalidomide--- RPS6KA1:PND-1186)	-
32310	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10018	Bivalent Ligand 305	MFH-5-103-1|Bivalent_Ligand_305	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MFH-5-103-1 (CRBN:pomalidomide--- RPS6KA3:PND-1186)	-
32358	111312	5294	-	PIK3CG	PI3CG|PI3K|PI3Kgamma|PIK3|p110gamma|p120-PI3K	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10016	Bivalent Ligand 307	FMF-04-147-1|Bivalent_Ligand_307	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: FMF-04-147-1 (CRBN:pomalidomide--- PIK3CG:AT7519)	-
32368	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10013	Bivalent Ligand 308	MFH-5-116-1|Bivalent_Ligand_308	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MFH-5-116-1 (CRBN:pomalidomide--- RPS6KA1:PND-1186)	-
32370	112111	6197	RP11-393H10.3	RPS6KA3	CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10013	Bivalent Ligand 308	MFH-5-116-1|Bivalent_Ligand_308	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MFH-5-116-1 (CRBN:pomalidomide--- RPS6KA3:PND-1186)	-
32416	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9992	Bivalent Ligand 312	INY-03-041-01|Bivalent_Ligand_312	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-03-041-01 (CRBN:lenalidomide---AKT1:Ipatasertib)	-
32418	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9992	Bivalent Ligand 312	INY-03-041-01|Bivalent_Ligand_312	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-03-041-01 (CRBN:lenalidomide--- AKT2:Ipatasertib)	-
32420	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9992	Bivalent Ligand 312	INY-03-041-01|Bivalent_Ligand_312	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-03-041-01 (CRBN:lenalidomide--- AKT3:Ipatasertib)	-
32456	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9996	Bivalent Ligand 316	INY-02-164|Bivalent_Ligand_316	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-02-164 (CRBN:Thalidomide---AKT1:Ipatasertib)	-
32458	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9996	Bivalent Ligand 316	INY-02-164|Bivalent_Ligand_316	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-02-164 (CRBN:Thalidomide--- AKT2:Ipatasertib)	-
32460	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	9996	Bivalent Ligand 316	INY-02-164|Bivalent_Ligand_316	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: INY-02-164 (CRBN:Thalidomide--- AKT3:Ipatasertib)	-
32548	112109	6195	RP11-492M19.2	RPS6KA1	HU-1|MAPKAPK1A|RSK|RSK1|p90Rsk	9606	Homo sapiens	degradation	target	Donovan KA (2020)	33275901	231643	10117	Bivalent Ligand 330	TL13-112|Bivalent_Ligand_330	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: TL13-112 (CRBN:pomalidomide---RPS6KA1:TAE684)	-
32568	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Zhang X (2021)	33783207	232094	10121	Bivalent Ligand 338	21-SLF|Bivalent_Ligand_338	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	123251	80344	GL014	DCAF11	PRO2389|WDR23	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: 21-SLF (DCAF11:not specified---FKBP12:SLF)	-
32600	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	degradation	target	Yu X (2021)	34855399	232882	10106	Bivalent Ligand 349	MS98|Bivalent_Ligand_349	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MS98 (VHL:VHL-2---AKT1:GDC-0068)	-
32602	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	Yu X (2021)	34855399	232882	10106	Bivalent Ligand 349	MS98|Bivalent_Ligand_349	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MS98 (VHL:VHL-2---AKT2:GDC-0068)	-
32604	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	degradation	target	Yu X (2021)	34855399	232882	10106	Bivalent Ligand 349	MS98|Bivalent_Ligand_349	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MS98 (VHL:VHL-2---AKT3:GDC-0068)	-
32606	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	degradation	target	Yu X (2021)	34855399	232882	10078	Bivalent Ligand 350	MS170|Bivalent_Ligand_350	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MS170 (CRBN:pomalidomide---AKT1:GDC-0068)	-
32608	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	Yu X (2021)	34855399	232882	10078	Bivalent Ligand 350	MS170|Bivalent_Ligand_350	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MS170 (CRBN:pomalidomide---AKT2:GDC-0068)	-
32610	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	degradation	target	Yu X (2021)	34855399	232882	10078	Bivalent Ligand 350	MS170|Bivalent_Ligand_350	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: MS170 (CRBN:pomalidomide---AKT3:GDC-0068)	-
32814	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Nalawansha DA (2022)	35311258	239583	10130	Bivalent ligand 409	KL-4|Bivalent_ligand_409	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	114343	8816	-	DCAF5	BCRG2|BCRP2|D14S1461E|WDR22	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: KL-4 (DCAF5:L3MBTL3-UNC1215 --- FKBP1A:SLF)	-
32832	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	degradation	target	Yu X (2022)	35119851	239588	10043	Bivalent ligand 417	compound 20|Bivalent_ligand_417	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 20 (VHL:VHL-1 --- AKT:AZD5363)	-
32834	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	degradation	target	Yu X (2022)	35119851	239588	10154	Bivalent ligand 418	compound 35|Bivalent_ligand_418	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 35 (CRBN:pomalidomide --- AKT:AZD5363)	-
32836	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	Yu X (2022)	35119851	239588	10043	Bivalent ligand 417	compound 20|Bivalent_ligand_417	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 20 (VHL:VHL-1 --- AKT:AZD5363)	-
32838	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	degradation	target	Yu X (2022)	35119851	239588	10154	Bivalent ligand 418	compound 35|Bivalent_ligand_418	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 35 (CRBN:pomalidomide --- AKT:AZD5363)	-
32840	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	degradation	target	Yu X (2022)	35119851	239588	10043	Bivalent ligand 417	compound 20|Bivalent_ligand_417	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 20 (VHL:VHL-1 --- AKT:AZD5363)	-
32842	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	degradation	target	Yu X (2022)	35119851	239588	10154	Bivalent ligand 418	compound 35|Bivalent_ligand_418	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: compound 35 (CRBN:pomalidomide --- AKT:AZD5363)	-
32848	111308	5290	-	PIK3CA	CLOVE|CWS5|MCAP|MCM|MCMTC|PI3K|p110-alpha	9606	Homo sapiens	degradation	target	Wang H (2022)	35344835	239591	10059	Bivalent ligand 421	HL-8|Bivalent_ligand_421	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: HL-8(VHL:VHL ligand --- PIK3CA:compound 15a)	-
32869	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Tao Y (2022)	36170674	241674	10355	Bivalent ligand 428	YT41R|Bivalent_ligand_428	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	115079	9730	-	VPRBP	DCAF1	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: YT41R (DCAF1:MY-1B --- FKBP12:SLF)	-
32871	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Tao Y (2022)	36170674	241674	10353	Bivalent ligand 429	YT47R|Bivalent_ligand_429	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	115079	9730	-	VPRBP	DCAF1	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: YT47R (DCAF1:MY-1B --- FKBP12:SLF)	-
33197	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Garcia G (2021)	33784499	240019	10202	Torin 2	Torin 2|9-(6-AMINOPYRIDIN-3-YL)-1-[3-(TRIFLUOROMETHYL)PHENYL]-1H,2H-BENZO[H]1,6-NAPHTHYRIDIN-2-ONE|Benzo[h][1,6]naphthyridin-2(1H)-one, 9-(6-amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-|9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one	-	CHEMSPIDER	26232176	C24H15F3N4O	small molecule	-	1223001-51-1	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: mTOR inhibitor (PMID: 26239364); viral inhibition mechanism undetermined	GUXXEUUYCAYESJ-UHFFFAOYSA-N
33198	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Garcia G (2021)	33784499	240019	10207	vistusertib	AZD-2014|AZD 2014|vistusertib	-	CHEMSPIDER	28294977	C25H30N6O3	small molecule	-	1009298-59-2	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: mTOR inhibitor (PMID: 27031247); viral inhibition mechanism undetermined	JUSFANSTBFGBAF-IRXDYDNUSA-N
33199	108757	2475	-	MTOR	FRAP|FRAP1|FRAP2|RAFT1|RAPT1	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Garcia G (2021)	33784499	240019	10258	dactolisib	BEZ-235|2-Methyl-2-{4-[3-methyl-2-oxo-8-(3-quinolinyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile|Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethyl-|NVP-BEZ 235|NVP-BEZ235|BEZ 235|NVP-BEZ235-NX|BEZ235|Dactolisib|NVPBEZ235|NVP BEZ235	-	CHEMSPIDER	10151099	C30H23N5O	small molecule	-	915019-65-7	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: mTOR inhibitor; viral inhibition mechanism undetermined	JOGKUKXHTYWRGZ-UHFFFAOYSA-N
33294	111549	5562	-	PRKAA1	AMPK|AMPKa1	9606	Homo sapiens	activator/sars-cov-2 inhibitor	target	Parthasarathy H (2023)	36417940	246230	323	Metformin	Metformine|Metformine pamoate|Haurymellin|1,1-Dimethylbiguanide|Metformina|N,N-Dimethylimidodicarbonimidic diamide|Metforminum|Metformin|Dimethylbiguanid	apo-metformin 850 mg tablets|g	DRUGBANK	DB00331	C4H11N5	small molecule	A10BD03|A10BD05|A10BD11|A10BD10|A10BD02|A10BD13|A10BD14|A10BD15|A10BD16|A10BD17|A10BD18|A10BD07|A10BD08|A10BA02|A10BD20	657-24-9	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction:AMPK activator; viral inhibition mechanism undetermined	XZWYZXLIPXDOLR-UHFFFAOYSA-N
33343	113996	8408	-	ULK1	ATG1|ATG1A|UNC51|Unc51.1|hATG1	9606	Homo sapiens	activator/sars-cov-2 inhibitor	target	Bojkova D (2023)	36644320	239397	10239	BL-918	Benzeneacetamide, alpha-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-, (alphaR)-|(2R)-2-({[3,5-Bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide	-	CHEMSPIDER	71116224	C23H15F8N3OS	small molecule	-	-	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: ULK1 activator; viral inhibition mechanism undetermined; anti-delta and omicron activity determined by a Caco-2-F03 cell line platform and caspase 3/7 activity as readout method	BDBWQANRZRCMMD-LJQANCHMSA-N
33426	106710	207	-	AKT1	AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Liu Q (2022)	35858407	244644	10172	GSK-690693	GSK-690693|4-{2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methyl-3-butyn-2-ol|3-Butyn-2-ol, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-|MFCD14105605|4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol	-	CHEMSPIDER	20557532	C21H27N7O3	small molecule	-	937174-76-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: AKT inhibitor; SIRT5 activator; antiviral activity against SARS-CoV-2 in Caco-2 cells	KGPGFQWBCSZGEL-ZDUSSCGKSA-N
33427	106711	208	-	AKT2	HIHGHH|PKBB|PKBBETA|PRKBB|RAC-BETA	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Liu Q (2022)	35858407	244644	10172	GSK-690693	GSK-690693|4-{2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methyl-3-butyn-2-ol|3-Butyn-2-ol, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-|MFCD14105605|4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol	-	CHEMSPIDER	20557532	C21H27N7O3	small molecule	-	937174-76-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: AKT inhibitor; SIRT5 activator; antiviral activity against SARS-CoV-2 in Caco-2 cells	KGPGFQWBCSZGEL-ZDUSSCGKSA-N
33428	115318	10000	-	AKT3	MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2	9606	Homo sapiens	inhibitor/sars-cov-2 inhibitor	target	Liu Q (2022)	35858407	244644	10172	GSK-690693	GSK-690693|4-{2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methyl-3-butyn-2-ol|3-Butyn-2-ol, 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-|MFCD14105605|4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol	-	CHEMSPIDER	20557532	C21H27N7O3	small molecule	-	937174-76-0	BIOGRID	-	-	-	-	-	-	-	-	-	-	Coronavirus Project SARS-CoV-2 indirect chemical interaction: AKT inhibitor; SIRT5 activator; antiviral activity against SARS-CoV-2 in Caco-2 cells	KGPGFQWBCSZGEL-ZDUSSCGKSA-N
33540	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Si R (2023)	37030566	250553	10751	Bivalent ligand 522	PROTAC-1|bivalent_ligand_522	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC-1 (VHL:VH032 --- BRAF:S5)	-
33542	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Si R (2023)	37030566	250553	10752	Bivalent ligand 523	PROTAC-2|bivalent_ligand_523	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC-2 (VHL:VH032 --- BRAF:S5)	-
33544	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Si R (2023)	37030566	250553	10753	Bivalent ligand 524	PROTAC-3|bivalent_ligand_524	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PROTAC-3 (VHL:VH032 --- BRAF:S5)	-
33672	107141	673	-	BRAF	B-RAF1|BRAF1|NS7|RAFB1	9606	Homo sapiens	degradation	target	Miller DSJ (2022)	35814929	256633	10804	Bivalent ligand 575	CST905|bivalent_ligand_575	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	113269	7428	-	VHL	HRCA1|RCA1|VHL1|pVHL	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: CST905 (VHL:VH032 --- BRAF:PLX7683)	-
33730	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Basu AA (2024)	38965383	254538	10823	Bivalent ligand 602	22-SLF|bivalent_ligand_602	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	117649	26263	-	FBXO22	FBX22|FISTC1	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: 22-SLF (FBXO22:22 --- FKBP12:SLF)	-
33732	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Basu AA (2024)	38965383	254538	10824	Bivalent ligand 603	22a-SLF|bivalent_ligand_603	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	117649	26263	-	FBXO22	FBX22|FISTC1	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: 22-SLF (FBXO22:22a --- FKBP12:SLF)	-
34008	113265	7422	RP1-261G23.1	VEGFA	MVCD1|VEGF|VPF	9606	Homo sapiens	degradation	target	Zhou P (2024)	39267779	256658	10946	Bivalent ligand 725	V5|bivalent_ligand_725	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	LYTAC	Lysosome Targeting Chimera; structured as glycopeptide ligand--linker--target binding moiety; target degraded via endosome-lysosome system	109703	3482	-	IGF2R	CD222|CIMPR|M6P-R|MPR1|MPRI	9606	Homo sapiens	lysosome-targeting protein	Standardized BVL Name: V5 (IGF2R:M6PR-A --- VEGF:VEGF-A2)	-
34050	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Reynders M (2021)	34432252	256663	10959	Bivalent ligand 738	PHOTAC-II-5|bivalent_ligand_738	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Opto-PROTAC	PROTAC variant in which a light-inducible degradation tag can be used to regulate target degradation activity; structured as E3 binding moiety with a photolabile caging group--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PHOTAC-II-5 (CRBN:glutarimide --- FKBP12:SLF)	-
34052	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Reynders M (2021)	34432252	256663	10960	Bivalent ligand 739	PHOTAC-II-6|bivalent_ligand_739	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	Opto-PROTAC	PROTAC variant in which a light-inducible degradation tag can be used to regulate target degradation activity; structured as E3 binding moiety with a photolabile caging group--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: PHOTAC-II-6 (CRBN:glutarimide --- FKBP12:SLF)	-
34102	108570	2280	RP11-314N13.2	FKBP1A	FKBP-12|FKBP-1A|FKBP1|FKBP12|PKC12|PKCI2|PPIASE	9606	Homo sapiens	degradation	target	Sun X (2019)	30729032	256670	10975	Bivalent ligand 754	RC32|bivalent_ligand_754	-	BIOGRID	-	-	small molecule	-	-	BIOGRID	PROTAC	Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS	119360	51185	AD-006	CRBN	MRT2|MRT2A	9606	Homo sapiens	recruited e3 ligase	Standardized BVL Name: RC32 (CRBN:pomalidomide --- FKBP1A:rapamycin)	-
