#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A0A663DJA2 uniprotkb:O60238 intact:EBI-25475906 intact:EBI-849893|uniprotkb:Q5JW63|uniprotkb:Q8NF87|uniprotkb:B0AZS9|intact:EBI-28977676|ensembl:ENSP00000370003 psi-mi:a0a663dja2_sars2(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short)|uniprotkb:orf10(gene name synonym) psi-mi:bni3l_human(display_long)|uniprotkb:NIP3-like protein X(gene name synonym)|uniprotkb:BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A(gene name synonym)|uniprotkb:Adenovirus E1B19K-binding protein B5(gene name synonym)|uniprotkb:BNIP3L(gene name)|psi-mi:BNIP3L(display_short)|uniprotkb:BNIP3A(gene name synonym)|uniprotkb:BNIP3H(gene name synonym)|uniprotkb:NIX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Li et al. (2021) imex:IM-29391|pubmed:34845370 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-28953729|imex:IM-29391-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR044342|refseq:YP_009725255.1 refseq:NP_004322.1|ensembl:ENSP00000370003|ensembl:ENST00000518611|ensembl:ENSP00000429851|ensembl:ENST00000520409|ensembl:ENSP00000428597|ensembl:ENST00000523515|ensembl:ENSP00000429698|dip:DIP-35187N|refseq:NP_001317420.1|ensembl:ENSG00000104765(gene)|ensembl:ENST00000380629(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|mint:O60238|reactome:R-HSA-6803204 - - - figure legend:4C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/12/20 2022/01/06 rogid:7Thf7AYh41AUnrzQdTSDW1NZr5s2697049 rogid:GPDlK/z2VOVzJspIhN8XNFPSVMo9606 rigid:BV7LkFDqLynvJrUqh31QwNwI0mo false ha tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60238 uniprotkb:A0A663DJA2 intact:EBI-849893|uniprotkb:Q5JW63|uniprotkb:Q8NF87|uniprotkb:B0AZS9|intact:EBI-28977676|ensembl:ENSP00000370003 intact:EBI-25475906 psi-mi:bni3l_human(display_long)|uniprotkb:NIP3-like protein X(gene name synonym)|uniprotkb:BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A(gene name synonym)|uniprotkb:Adenovirus E1B19K-binding protein B5(gene name synonym)|uniprotkb:BNIP3L(gene name)|psi-mi:BNIP3L(display_short)|uniprotkb:BNIP3A(gene name synonym)|uniprotkb:BNIP3H(gene name synonym)|uniprotkb:NIX(gene name synonym) psi-mi:a0a663dja2_sars2(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short)|uniprotkb:orf10(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Li et al. (2021) imex:IM-29391|pubmed:34845370 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-28953710|imex:IM-29391-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004322.1|ensembl:ENSP00000370003|ensembl:ENST00000518611|ensembl:ENSP00000429851|ensembl:ENST00000520409|ensembl:ENSP00000428597|ensembl:ENST00000523515|ensembl:ENSP00000429698|dip:DIP-35187N|refseq:NP_001317420.1|ensembl:ENSG00000104765(gene)|ensembl:ENST00000380629(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|mint:O60238|reactome:R-HSA-6803204 interpro:IPR044342|refseq:YP_009725255.1 - - - figure legend:4D|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/12/20 2022/01/06 rogid:GPDlK/z2VOVzJspIhN8XNFPSVMo9606 rogid:7Thf7AYh41AUnrzQdTSDW1NZr5s2697049 rigid:BV7LkFDqLynvJrUqh31QwNwI0mo false - ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9GZQ8 uniprotkb:A0A663DJA2 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 intact:EBI-25475906 psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:a0a663dja2_sars2(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short)|uniprotkb:orf10(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Li et al. (2021) imex:IM-29391|pubmed:34845370 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-28953757|imex:IM-29391-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N interpro:IPR044342|refseq:YP_009725255.1 - - - figure legend:4F|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/12/20 2022/01/06 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 rogid:7Thf7AYh41AUnrzQdTSDW1NZr5s2697049 rigid:+vf+ROR5sPHvbYKJEwEjc1LxPHY false - ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60238 uniprotkb:A0A663DJA2 intact:EBI-849893|uniprotkb:Q5JW63|uniprotkb:Q8NF87|uniprotkb:B0AZS9|intact:EBI-28977676|ensembl:ENSP00000370003 intact:EBI-25475906 psi-mi:bni3l_human(display_long)|uniprotkb:NIP3-like protein X(gene name synonym)|uniprotkb:BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A(gene name synonym)|uniprotkb:Adenovirus E1B19K-binding protein B5(gene name synonym)|uniprotkb:BNIP3L(gene name)|psi-mi:BNIP3L(display_short)|uniprotkb:BNIP3A(gene name synonym)|uniprotkb:BNIP3H(gene name synonym)|uniprotkb:NIX(gene name synonym) psi-mi:a0a663dja2_sars2(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short)|uniprotkb:orf10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Li et al. (2021) imex:IM-29391|pubmed:34845370 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-28953749|imex:IM-29391-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004322.1|ensembl:ENSP00000370003|ensembl:ENST00000518611|ensembl:ENSP00000429851|ensembl:ENST00000520409|ensembl:ENSP00000428597|ensembl:ENST00000523515|ensembl:ENSP00000429698|dip:DIP-35187N|refseq:NP_001317420.1|ensembl:ENSG00000104765(gene)|ensembl:ENST00000380629(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|mint:O60238|reactome:R-HSA-6803204 interpro:IPR044342|refseq:YP_009725255.1 - - - figure legend:4E|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2021/12/20 2022/01/06 rogid:GPDlK/z2VOVzJspIhN8XNFPSVMo9606 rogid:7Thf7AYh41AUnrzQdTSDW1NZr5s2697049 rigid:BV7LkFDqLynvJrUqh31QwNwI0mo false - ha tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A0A663DJA2 uniprotkb:O60238 intact:EBI-25475906 intact:EBI-849893|uniprotkb:Q5JW63|uniprotkb:Q8NF87|uniprotkb:B0AZS9|intact:EBI-28977676|ensembl:ENSP00000370003 psi-mi:a0a663dja2_sars2(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short)|uniprotkb:orf10(gene name synonym) psi-mi:bni3l_human(display_long)|uniprotkb:NIP3-like protein X(gene name synonym)|uniprotkb:BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A(gene name synonym)|uniprotkb:Adenovirus E1B19K-binding protein B5(gene name synonym)|uniprotkb:BNIP3L(gene name)|psi-mi:BNIP3L(display_short)|uniprotkb:BNIP3A(gene name synonym)|uniprotkb:BNIP3H(gene name synonym)|uniprotkb:NIX(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Li et al. (2021) imex:IM-29391|pubmed:34845370 taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-28953775|imex:IM-29391-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR044342|refseq:YP_009725255.1 refseq:NP_004322.1|ensembl:ENSP00000370003|ensembl:ENST00000518611|ensembl:ENSP00000429851|ensembl:ENST00000520409|ensembl:ENSP00000428597|ensembl:ENST00000523515|ensembl:ENSP00000429698|dip:DIP-35187N|refseq:NP_001317420.1|ensembl:ENSG00000104765(gene)|ensembl:ENST00000380629(transcript)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|interpro:IPR010548(BNIP3)|mint:O60238|reactome:R-HSA-6803204 - - - figure legend:4G|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2021/12/20 2022/01/06 rogid:7Thf7AYh41AUnrzQdTSDW1NZr5s2697049 rogid:GPDlK/z2VOVzJspIhN8XNFPSVMo9606 rigid:BV7LkFDqLynvJrUqh31QwNwI0mo false ha tag:n-n flag tag:n-n - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)