#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7Z2W4-1	uniprotkb:O15037	intact:EBI-922555|ensembl:ENSP00000242351	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:q7z2w4-1(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPL(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kmiec et al. (2021)	imex:IM-29348|pubmed:34695163	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27123408|imex:IM-29348-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:5|comment:The 1–256 and 1–352 truncation mutants bound  lower levels of KHNYN and TRIM25 than the full length protein.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/29	2021/11/11	rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:4Pb1viEj6tyPJipdtGusS9JnLEA	false	sufficient binding region:1-256|mutation decreasing interaction strength:899-899|green fluorescent protein tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7Z2W4-1	uniprotkb:Q14258	intact:EBI-922555|ensembl:ENSP00000242351	intact:EBI-2341129|intact:EBI-28973868|ensembl:ENSP00000323889|ensembl:ENSP00000445961	psi-mi:q7z2w4-1(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPL(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)	psi-mi:tri25_human(display_long)|uniprotkb:TRIM25(gene name)|psi-mi:TRIM25(display_short)|uniprotkb:EFP(gene name synonym)|uniprotkb:RNF147(gene name synonym)|uniprotkb:ZNF147(gene name synonym)|uniprotkb:Zinc finger protein 147(gene name synonym)|uniprotkb:Estrogen-responsive finger protein(gene name synonym)|uniprotkb:RING finger protein 147(gene name synonym)|uniprotkb:Ubiquitin/ISG15-conjugating enzyme TRIM25(gene name synonym)|uniprotkb:Tripartite motif-containing protein 25(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM25(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kmiec et al. (2021)	imex:IM-29348|pubmed:34695163	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27123408|imex:IM-29348-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000242351(transcript)	ensembl:ENSP00000323889|ensembl:ENSP00000445961|refseq:NP_005073.2|ensembl:ENSG00000121060(gene)|ensembl:ENST00000316881(transcript)|ensembl:ENST00000537230(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033280"(response to vitamin D)|go:"GO:0039552"(RIG-I binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043627"(response to estrogen)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902186"(obsolete regulation of viral release from host cell)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042753|interpro:IPR043136|mint:Q14258|rcsb pdb:4CFG|rcsb pdb:4LTB|rcsb pdb:5EYA|rcsb pdb:5FER|rcsb pdb:5NT1|rcsb pdb:5NT2|rcsb pdb:6FLM|rcsb pdb:6FLN|reactome:R-HSA-1169408|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-5689896|reactome:R-HSA-877300|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	-	-	figure legend:5|comment:The 1–256 and 1–352 truncation mutants bound  lower levels of KHNYN and TRIM25 than the full length protein.|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/29	2021/11/11	rogid:iJy4W/YX/vVXGbFd+GnfoKlo8aA9606	rogid:NhFfC0IxHvxPIt2YnKCPsPKuiQA9606	rigid:4Pb1viEj6tyPJipdtGusS9JnLEA	false	sufficient binding region:1-256|mutation decreasing interaction strength:899-899|green fluorescent protein tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7Z2W4-2	uniprotkb:O15037	intact:EBI-922559|ensembl:ENSP00000419855	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:q7z2w4-2(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPS(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kmiec et al. (2021)	imex:IM-29348|pubmed:34695163	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27123419|imex:IM-29348-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000471652(transcript)|uniprotkb:Q7Z2W4-2(isoform-parent)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	isoform-comment:No experimental confirmation available.	-	figure legend:5|comment:The 1–256 and 1–352 truncation mutants bound  lower levels of KHNYN and TRIM25 than the full length protein.|comment:"ZAP-L (isoform 1) coimmunoprecipitated endogenous KHNYN and TRIM25 more efficiently than ZAP-S (isoform 2)."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/29	2021/11/11	rogid:iYC6SVjVUbaBJ7RnzFluOsH9UAQ9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:jzmSOSerM3AgN3nXHzogT59/XHk	false	mutation increasing interaction strength:699-699|sufficient binding region:1-256|green fluorescent protein tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7Z2W4-2	uniprotkb:Q14258	intact:EBI-922559|ensembl:ENSP00000419855	intact:EBI-2341129|intact:EBI-28973868|ensembl:ENSP00000323889|ensembl:ENSP00000445961	psi-mi:q7z2w4-2(display_long)|uniprotkb:ZC3HAV1(gene name)|psi-mi:ZC3HAV1(display_short)|uniprotkb:ZC3HDC2(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 2(gene name synonym)|uniprotkb:Zinc finger antiviral protein(gene name synonym)|uniprotkb:PRO1677(orf name)|uniprotkb:ZAPS(isoform synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 13(gene name synonym)|uniprotkb:Inactive Poly [ADP-ribose] polymerase 13(gene name synonym)	psi-mi:tri25_human(display_long)|uniprotkb:TRIM25(gene name)|psi-mi:TRIM25(display_short)|uniprotkb:EFP(gene name synonym)|uniprotkb:RNF147(gene name synonym)|uniprotkb:ZNF147(gene name synonym)|uniprotkb:Zinc finger protein 147(gene name synonym)|uniprotkb:Estrogen-responsive finger protein(gene name synonym)|uniprotkb:RING finger protein 147(gene name synonym)|uniprotkb:Ubiquitin/ISG15-conjugating enzyme TRIM25(gene name synonym)|uniprotkb:Tripartite motif-containing protein 25(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM25(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kmiec et al. (2021)	imex:IM-29348|pubmed:34695163	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27123419|imex:IM-29348-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-922540(zcc2_human)|ensembl:ENSG00000105939(gene)|ensembl:ENST00000471652(transcript)|uniprotkb:Q7Z2W4-2(isoform-parent)	ensembl:ENSP00000323889|ensembl:ENSP00000445961|refseq:NP_005073.2|ensembl:ENSG00000121060(gene)|ensembl:ENST00000316881(transcript)|ensembl:ENST00000537230(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033280"(response to vitamin D)|go:"GO:0039552"(RIG-I binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043627"(response to estrogen)|go:"GO:0045087"(innate immune response)|go:"GO:0045296"(cadherin binding)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902186"(obsolete regulation of viral release from host cell)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042753|interpro:IPR043136|mint:Q14258|rcsb pdb:4CFG|rcsb pdb:4LTB|rcsb pdb:5EYA|rcsb pdb:5FER|rcsb pdb:5NT1|rcsb pdb:5NT2|rcsb pdb:6FLM|rcsb pdb:6FLN|reactome:R-HSA-1169408|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-5689896|reactome:R-HSA-877300|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	-	isoform-comment:No experimental confirmation available.	-	figure legend:5|comment:The 1–256 and 1–352 truncation mutants bound  lower levels of KHNYN and TRIM25 than the full length protein.|comment:"ZAP-L (isoform 1) coimmunoprecipitated endogenous KHNYN and TRIM25 more efficiently than ZAP-S (isoform 2)."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2021/10/29	2021/11/11	rogid:iYC6SVjVUbaBJ7RnzFluOsH9UAQ9606	rogid:NhFfC0IxHvxPIt2YnKCPsPKuiQA9606	rigid:jzmSOSerM3AgN3nXHzogT59/XHk	false	mutation increasing interaction strength:699-699|sufficient binding region:1-256|green fluorescent protein tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)