#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:Q9Y6K9-1	intact:EBI-25475864	intact:EBI-27121550|ensembl:ENSP00000471166|ensembl:ENSP00000479662	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:q9y6k9-1(display_long)|uniprotkb:FIP-3(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:IKBKG(gene name)|psi-mi:IKBKG(display_short)|uniprotkb:FIP3(gene name synonym)|uniprotkb:NEMO(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wenzel et al. (2021)	imex:IM-29334|pubmed:34675436	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27121547|imex:IM-29334-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-81279(isoform-parent)|ensembl:ENSG00000269335(gene)|ensembl:ENST00000594239(transcript)|ensembl:ENST00000611071(transcript)	-	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:3 A/D/E, Supp. figure 2|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/01	2021/11/08	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:9OeZIMeJvNtDEMoiLaKwVEpxSSM9606	rigid:Zxk0CFN2kAYjZkZRn9uZnYCWGfg	false	-	biological feature:83-84|biological feature:205-206|biological feature:231-232|biological feature:304-305|biological feature:313-314|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0102"(sequence tag identification)|psi-mi:"MI:0113"(western blot)
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:Q9Y6K9-1	intact:EBI-25475864	intact:EBI-27121550|ensembl:ENSP00000471166|ensembl:ENSP00000479662	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:q9y6k9-1(display_long)|uniprotkb:FIP-3(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:IKBKG(gene name)|psi-mi:IKBKG(display_short)|uniprotkb:FIP3(gene name synonym)|uniprotkb:NEMO(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wenzel et al. (2021)	imex:IM-29334|pubmed:34675436	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27121623|imex:IM-29334-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	intact:EBI-81279(isoform-parent)|ensembl:ENSG00000269335(gene)|ensembl:ENST00000594239(transcript)|ensembl:ENST00000611071(transcript)	-	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:3F, Supp. figure 3|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat/km:43.0(per mole per second)	2021/11/01	2021/11/08	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:9OeZIMeJvNtDEMoiLaKwVEpxSSM9606	rigid:Zxk0CFN2kAYjZkZRn9uZnYCWGfg	false	-	sufficient binding region:222-241|biological feature:231-232|mutation disrupting interaction rate:231-231	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P0DTD1-PRO_0000449623	uniprotkb:O88522	intact:EBI-25475864	intact:EBI-998011|uniprotkb:Q924H4|ensembl:ENSMUSP00000109762|ensembl:ENSMUSP00000109763|ensembl:ENSMUSP00000109768|ensembl:ENSMUSP00000126770	psi-mi:p0dtd1-pro_0000449623(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:ORF1ab polyprotein(gene name synonym)|uniprotkb:1a-1b(orf name)	psi-mi:nemo_mouse(display_long)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:Ikbkg(gene name)|psi-mi:Ikbkg(display_short)|uniprotkb:Nemo(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Wenzel et al. (2021)	imex:IM-29334|pubmed:34675436	taxid:2697049(SARS-CoV-2)|taxid:2697049(SARS-CoV-2)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27121653|imex:IM-29334-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-25492095(chain-parent)|uniprotkb:P0DTD1(chain-parent)	go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:O88522|rcsb pdb:2V4H|rcsb pdb:2ZVN|rcsb pdb:2ZVO|rcsb pdb:3F89|rcsb pdb:3JSV|rcsb pdb:4OWF|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-4755510|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-9020702|reactome:R-MMU-933542|reactome:R-MMU-937039|reactome:R-MMU-937041|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0010628"(positive regulation of gene expression)|reactome:R-MMU-975144|ensembl:ENSMUSG00000004221(gene)|ensembl:ENSMUST00000114127(transcript)|ensembl:ENSMUST00000114128(transcript)|ensembl:ENSMUST00000114133(transcript)|ensembl:ENSMUST00000164101(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|refseq:XP_011245829.1|refseq:NP_001154895.1|refseq:NP_034677.2|refseq:XP_006527913.1|refseq:XP_006527914.1|refseq:XP_006527915.1|dip:DIP-29811N	-	chain-seq-start:3264|chain-seq-end:3569	-	figure legend:3F, Supp. figure 3 B/C|dataset:Virus - Publications including interactions involving viral proteins|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2021/11/01	2021/11/08	rogid:9u1TJXDTORfCyqj2bv2TlDMZ65c2697049	rogid:xdq9J5m7CDC1X/4TfHZVGSYKq8U10090	rigid:Yx7KaD2FrvnuEWqXGQvi2koZ1qQ	false	-	sufficient binding region:222-241|biological feature:231-232	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0102"(sequence tag identification)